oxazoles has been researched along with rilmenidine in 341 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 61 (17.89) | 18.7374 |
| 1990's | 157 (46.04) | 18.2507 |
| 2000's | 99 (29.03) | 29.6817 |
| 2010's | 24 (7.04) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guillet, C; Passeron, J | 1 |
| Hamilton, CA; Howie, CA; Reid, JL; Yakubu, MA | 1 |
| Berger, SB; Maiese, K; Pek, L; Reis, DJ | 1 |
| Christen, O; Göthert, M; Michel, MC; Molderings, GJ; Schäfer, SG | 1 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill, M; Feldman, J; Greney, H; Stutzmann, J; Tibirica, E | 1 |
| Gundlach, AL; Jarrott, B; King, PR; Louis, WJ | 2 |
| Harron, DW | 3 |
| Laurent, S; Safar, M | 1 |
| Barrès, C; Koenig-Bérard, E; Sannajust, F; Sassard, J | 1 |
| Cerutti, C; Koenig-Bérard, E; Sannajust, F; Sassard, J | 1 |
| Head, GA; Sannajust, F | 4 |
| Bousquet, P; Gonon, F; Mermet, C; Suaud-Chagny, MF; Tibiriça, E | 1 |
| Harron, DW; McKaigue, JP | 1 |
| Macrae, IM; McAuley, MA; Reid, JL | 1 |
| Berger, SB; Golanov, EV; Reis, DJ; Yamamoto, S | 1 |
| Ernsberger, P; Feinland, G; Gomez, RE; Reis, DJ | 1 |
| Beevers, DG; Bulpitt, CJ; Dollery, CT; Fletcher, AE; Wilkinson, R | 1 |
| Bousquet, P; Feldman, J; Gonon, F; Mermet, C; Monassier, L; Tibiriça, E | 1 |
| Bidet, M; Parini, A; Poujeol, P | 2 |
| Frutoso, J; Geelen, G; Ghaemmaghami, F; Gharib, C; Ibanez, J; Vincent, M | 1 |
| Burke, S; Head, GA | 1 |
| Smits, JF; Struyker-Boudier, HA | 1 |
| Frank, R; Grosgogeat, Y; Guillet, C; Jondeau, G; Poulain, F; Tonet, J; Vivet, P | 1 |
| De Mey, JG; Eerdmans, PH; Struyker Boudier, HA | 1 |
| Harron, DW; Spiers, JP; Wilson, R | 1 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill, M; Feldman, J | 1 |
| Hamilton, CA; Howie, CA; Jardine, E; Reid, JL; Yakubu, MA | 1 |
| Dhib, M; Fillastre, JP | 1 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill, M; Feldman, J; Tibiriça, E | 1 |
| Dresse, A; Scuvée-Moreau, J | 1 |
| Doyle, AE; Jarrott, B; Lewis, SJ | 2 |
| Fillastre, JP | 1 |
| Damase-Michel, C; Dard, B; Macquin-Mavier, I; Montastruc, JL; Tran, MA; Valet, P | 1 |
| Corcoran, C; Mansy, S; Wilkinson, R | 1 |
| Fiorentini, C; Guazzi, M; Guillet, C | 1 |
| Pannier, B; Safar, M | 1 |
| Safar, ME | 2 |
| Callens-el Amrani, F; Paolaggi, F; Swynghedauw, B | 2 |
| Belcourt, A; Bousquet, P; Bricca, G; Dontenwill, M; Feldman, J; Molines, A; Tibirica, E | 3 |
| Coupry, I; Koenig, E; Lachaud, V; Parini, A; Podevin, RA | 2 |
| Li, CG; Rand, MJ | 2 |
| Damase-Michel, C; Koenig-Berard, E; Macquin-Mavier, I; Montastruc, JL; Tran, MA; Valet, P | 1 |
| Dinh Xuan, AT; Lockhart, A | 1 |
| Leary, WP | 1 |
| Mahieux, F | 1 |
| Barrès, C; Cerutti, C; Julien, C; Koenig-Bérard, E; Sannajust, F; Sassard, J | 1 |
| Bidet, M; Coupry, I; Lachaud, V; Parini, A; Podevin, RA; Poujeol, P | 1 |
| Bromet, N; Genissel, P | 1 |
| Ketelslegers, JM; Lambert, AE; Mpoy, M; Vandeleene, B | 2 |
| Dall, JL | 1 |
| Brisgand, B; Daelemans, R; Dratwa, M; Lameire, N; Lins, RL; Sennesael, J; Verbeelen, D | 1 |
| Ausiello, M; Brignoli, M; de Divitiis, O; Di Somma, S; Galderisi, M; Liguori, V; Magnotta, C; Natale, N; Petitto, M | 1 |
| Davies, DS; Murray, S; Watson, D | 1 |
| Ehrhardt, JD | 1 |
| de Jonge, A; Jonkman, FA; Thoolen, MJ; Timmermans, PB; van Zwieten, PA; Wilffert, B | 1 |
| Al-Damluji, S; Besser, GM; Grossman, A; Turner, P; Weerasuriya, K | 1 |
| Fourtillan, JB; Girault, J; Lefebvre, MA; Mignot, A; Ung, HL | 1 |
| Beau, B; Delbarre, G; Koenig-Berard, E; Labrid, C; Lhoste, F; Tierney, C | 1 |
| Dresse, A; Scuvée-Moreau, J; Seutin, V | 1 |
| Koenig-Berard, E; Nadaud, D; Stinus, L; Tierney, C | 1 |
| Doyle, AE; Jarrott, B; Lewis, SJ; Louis, WJ | 1 |
| Clerici, C; Harf, A; Macquin-Mavier, I | 1 |
| Albin, H; Bromet, N; Fourtillan, JB; Genissel, P; Mignot, A | 1 |
| Ehrhardt, JD; Genissel, P; Pozet, N; Singlas, E; Zech, P | 1 |
| Van Zwieten, PA | 4 |
| Davies, DS; Dollery, CT; Duchier, J; Pannier, B; Safar, ME | 1 |
| Aliot, E; Florentin, J; Gilgenkrantz, JM; Saulnier, JP; Zannad, F | 1 |
| Levy, B; N'guyen van Cao, A; Slama, R | 1 |
| Brisgand, B; Fillastre, JP; Ostermann, G; Schmitt, J | 1 |
| Fillastre, JP; Galinier, F; Le Bihan, G; Letac, B; Schwartz, J | 1 |
| Galley, P; Hessel, JL; Manciet, G; Michel, JP | 1 |
| Beau, B; Brisgand, B; Laurin, S; Mahieux, F; Paraire, M; Vitou, P | 1 |
| Bourreau, JP; Tricoche, R | 1 |
| Advenier, C; Dinh Xuan, AT; Lockhart, A; Matran, R; Regnard, J; Vitou, P | 1 |
| Anglade, F; Damase-Michel, C; Dang Tran, L; de Saint-Blanquat, G; Koenig-Berard, E; Montastruc, JL; Tran, MA; Valet, P | 1 |
| Herman, AG; Jordaens, FH; Verbeuren, TJ; Zonnekeyn, LL | 1 |
| Coupry, I; Dausse, JP; Koenig, E; Lachaud, V; Parini, A; Podevin, RA | 1 |
| Beau, B; Begue, JM; Bromet, N; Du Vignaud, P; Genissel, P; Grislain, L; Guillouzo, A; Mocquard, MT; Ratanasavanh, D | 1 |
| Shaw, E; Turner, P; Weerasuriya, K | 1 |
| Dampney, RA; Li, YW | 1 |
| Gregoire, JR; Sheps, SG | 1 |
| Starke, K; Szabo, B; Urban, R | 3 |
| Advenier, C; Biyah, K | 1 |
| Jacob, R; Rupp, H | 1 |
| Gundlach, AL; King, PR; Louis, WJ; Suzuki, S | 2 |
| Bramwell, S; Regunathan, S; Reis, DJ | 1 |
| Penner, SB; Smyth, DD | 3 |
| Combes-George, M; Mory, G; Nechad, M; Parini, A; Tesson, F | 1 |
| Head, GA | 2 |
| Szabo, B; Urban, R | 2 |
| Laragh, JH | 2 |
| Elliott, HL; MacPhee, G; Panfilov, V; Reid, JL | 1 |
| Chernobelski, M; Mayorov, D; Medvedev, O | 1 |
| Gundlach, AL; King, PR; Louis, WJ | 2 |
| Handley, SL; Jackson, HC; Jordan, S; Nutt, DJ | 1 |
| Browne, SE; Macrae, IM | 2 |
| García-Sevilla, JA; Pineda, J; Ugedo, L | 1 |
| Hamilton, CA; Jardine, E; Reid, JL | 1 |
| Gundlach, AL; King, PR; Louis, WJ; Nero, TL; Suzuki, S | 1 |
| Godwin, SJ; Head, GA; Sannajust, F | 1 |
| Cechetto, DF; Kline, RL; van der Mark, J | 1 |
| Feinstein, DL; Golanov, EV; Regunathan, S; Reis, DJ | 1 |
| DeLuca, N; Lorino, G; Rosiello, G; Rubattu, S; Sarno, D; Trimarco, B; Volpe, M | 1 |
| Aparicio, M; Dratwa, M; el Esper, N; Fillastre, JP; Levaltier, B; Lins, R; Meyrier, A; Mignon, F; Ryckelynck, JP; Sennesael, J | 1 |
| Corcoran, C; Coupez, G; Creytens, G; Opsomer, M; Pelemans, W; Van Dessel, A; Verhaeghe, J | 1 |
| Codis, P; Fevrier, B; Pillion, G; Schutz, D | 1 |
| Li, P; Penner, SB; Smyth, DD | 1 |
| Christen, MO; Collins, LA; Dreshaj, I; Ernsberger, P; Graff, LM; Graves, ME; Grove, DL; Haxhiu, MA; Schäfer, SG | 1 |
| Christen, O; Göthert, M; Molderings, GJ; Schäfer, SG | 1 |
| Cechetto, DF; Kline, RL | 3 |
| Janssen, BJ; Oosting, J; Struyker-Boudier, HA; Tyssen, CM | 1 |
| Boucher, M; Chassaing, C; Dubar, M; Duchêne-Marullaz, P; Vivet, P | 1 |
| Ambrosi, P; Lambert, M; Luccioni, R; Scemama, M | 1 |
| Bousquet, P; Bricca, G; Dontenwill, M; Tibiriça, E | 1 |
| Capuana, G; Guillet, C; Indovina, A; Licata, G; Lipari, R; Mazzola, G; Merlino, G; Parrinello, G; Scaglione, R | 1 |
| Luccioni, R | 1 |
| Anderson, WP; Evans, RG | 1 |
| Elghozi, JL; Février, B; Girard, A | 1 |
| Dabire, H; Levy, BI; Poitevin, P; Safar, ME | 1 |
| Chan, CK; Head, GA; Sannajust, F | 1 |
| Argenziano, L; De Luca, N; Iovino, G; Morisco, C; Russo, R; Sarno, D; Trimarco, B; Volpe, M | 1 |
| Beucler, I; Dairou, F; Février, B; Scemama, M | 2 |
| Hayashi, Y; Kamibayashi, T; Mammoto, T; Takada, K; Yamatodani, A; Yoshiya, I | 2 |
| Donnelly, R; Morris, AD; Panfilov, V; Reid, JL | 1 |
| Harron, DW; Hasson, B; King, DJ; McClelland, RJ; Regan, M | 1 |
| Gargalidis-Moudanos, C; Parini, A | 1 |
| Chudek, J; Nowicki, M; Wiecek, A | 1 |
| Donnelly, R; Morris, AD; Panfilov, V; Reid, JL; Scemama, M | 1 |
| Boucher, M; Chapuy, E; Chassaing, C; Dubar, M | 2 |
| Fröhlich, R; Illes, P; Szabo, B | 1 |
| Chan, CK; Head, GA | 1 |
| Frishman, WH; Yu, A | 1 |
| Boulanger, CM; Illiano, S; Marsault, R; Taddei, S; Vanhoutte, PM | 1 |
| Chu, TC; Gluchowski, C; Hughes, BW; Potter, DE; Wong, W | 1 |
| Johns, EJ; Zhang, T | 1 |
| Bousquet, P; De Jong, W; Feldman, J; Monassier, L; Roegel, JC; Yannoulis, N | 1 |
| Berthault, MF; Dubar, M; Ferré, P; Ktorza, A; Morin, J; Pénicaud, L | 2 |
| Avellar, MC; Markus, RP | 1 |
| Anderson, WP; Evans, RG; Fitzgerald, SM; Malpas, SC; Shweta, A | 1 |
| Van den Buuse, M | 1 |
| Hayashi, Y; Kamibayashi, T; Kitamura, S; Mammoto, T; Takada, K; Yamatodani, A; Yoshiya, I | 1 |
| Lada, W | 1 |
| Arrais, CA; Camargo, LA; Menani, JV; Renzi, A; Saad, R; Saad, WA; Silveira, JE | 1 |
| Piletz, JE; Reis, DJ | 1 |
| Cario-Toumaniantz, C; Loirand, G; Pacaud, P | 1 |
| Kazaz, C; Sözmen, B; Sözmen, EY; Taşkiran, D; Tüzün, S | 1 |
| Abdel-Rahman, AA; El-Mas, MM | 5 |
| Arcade, B; Cribier, B; Grosshans, E; Michel, C | 1 |
| Burke, SL; Chan, CK; Head, GA | 2 |
| Bousquet, P; De Jong, W; Feldman, J; Roegel, JC; Yannoulis, N | 1 |
| Bobik, A; Dilley, R; Kanellakis, P | 1 |
| Balazovjech, I; Dubai, G; Dvorak, I; Januszewicz, W; Krupa-Wojciechowska, B; Kubasik, A; Kuch-Wocial, A; Polak, G; Sadowski, Z; Simon, K; Stejfa, M; Szwed, H | 1 |
| Cechetto, DF; Dixon, SJ; Ozog, MA; Wilson, JX | 1 |
| Ali, A; Cheng, HY; Ting, KN; Wilson, VG | 1 |
| Burke, SL; Head, GA | 6 |
| Gundlach, AL; Hosseini, AR; Iakovidis, D; Jackman, GP; King, PR; Louis, WJ; Nero, TL; Suzuki, S | 1 |
| Gundlach, AL; Hosseini, AR; Jackman, GP; King, PR; Louis, WJ | 1 |
| Kunduzova, OR; Medvedev, OS; Medvedeva, NA; Murashev, AN | 3 |
| Burke, SL; Head, GA; Malpas, SC | 1 |
| Burke, SL; Head, GA; Tritton, SB; van den Buuse, M | 1 |
| Godwin, SJ; Head, GA; Parkin, ML; Tortelli, CF | 1 |
| Amah, G | 1 |
| Blue, DR; Dillon, MP; Eglen, RM; Jasper, JR; Lesnick, JD; MacLennan, SJ; Zhu, QM | 2 |
| Bock, C; Niederhoffer, N; Szabo, B | 1 |
| Hébert, CA; Kudo, LH; Rouch, AJ | 1 |
| Drzewoski, J; Wiśniewska-Jarosińska, M | 1 |
| Ducher, M; Fauvel, JP; Laville, M; Najem, R; Ryon, B | 1 |
| Bousquet, P; Brasili, L; Bruban, V; Dontenwill, M; Feldman, J; Giannella, M; Greney, H; Pigini, M | 1 |
| Bock, C; Niederhoffer, N; Nordheim, U; Szabo, B | 1 |
| Peters, SL; Van Zwieten, PA | 1 |
| Bousquet, P; Feldman, J; Pompermayer, K; Salgado, MC | 1 |
| Masek, K; Sevcík, J | 1 |
| Bousquet, P; Feldman, J | 1 |
| Robles, NR | 1 |
| Bauduceau, B; Dupuy, O; Mayaudon, H | 3 |
| Castro Resende, AC; Leão, MC; Lima, AF; Mesquita Ferreira, AG; Moreira, CF; Nunes, FR; Sena, KM; Silveira, SS; Soares de Moura, RS | 1 |
| Polónia, J | 1 |
| Kourilsky, O | 1 |
| Argengiano, L; de Luca, N; Guerrera, L; Iovino, GL; Izzo, R; Trimarco, B | 1 |
| Bousquet, P | 2 |
| Esler, M | 1 |
| Reid, JL | 2 |
| Bönisch, H; Brüss, M; Göthert, M; Likungu, J; Molderings, GJ | 1 |
| Spinar, J; Vítovec, J | 1 |
| Argenziano, L; De Luca, N; Fontana, D; Iovino, G; Izzo, R; Trimarco, B; Vecchione, C | 1 |
| Schachter, M | 1 |
| Bousquet, P; Bruban, V; Feldman, J; Sy, GY | 1 |
| Burke, SL; Head, GA; Mayorov, DN | 1 |
| Abdel-Rahman, AA; El-Mas, MM; Zhang, J | 1 |
| Bousquet, P; Bruban, V; Ehrhardt, JD; Feldman, J; Pfeiffer, B; Pompermayer, K; Renard, P; Scalbert, E; Schann, S | 1 |
| Cohen, AF; de Visser, SJ; Schoemaker, RC; van Gerven, JM | 1 |
| Fritz, T; Szabo, B; Wedzony, K | 1 |
| Burke, SL; Head, GA; Sannajust, FJ | 1 |
| Head, GA; Janssen, BJ; Lukoshkova, EV | 1 |
| Bousquet, P; Bruban, V; Ehrhardt, JD; Estato, V; Feldman, J; Monassier, L; Renard, P; Scalbert, E; Schann, S | 1 |
| Nurminen, ML | 1 |
| Kratochvíl'ová, H; Remková, A | 1 |
| Abdel-Rahman, AA; Zhang, J | 4 |
| Cohen, AF; de Visser, SJ; Nanhekhan, L; Schoemaker, RC; van der Post, JP; van Gerven, JM | 1 |
| Choi, DH; Choi, SH; Chun, BG; Kim, DH; Park, YG | 1 |
| Widimský, J | 1 |
| Penner, SB; Pirnat, D; Smyth, DD | 1 |
| Kourilsky, O; Meurin, P | 1 |
| Bousquet, P; Catelli, M; Feldman, J; Tibirica, E | 1 |
| Godwin, SJ; Head, GA; Parkin, ML | 1 |
| Camilleri, G; Clerson, P; Portal, B; Quiniou, G | 1 |
| Artigues-Varin, C; Mulder, P; Richard, V; Thuillez, C; Varin, R | 1 |
| Khirmanov, VN | 1 |
| Borbás, S; Dienes, BS; Farsang, C; Lengyel, M; Zorándi, A | 1 |
| Bogdański, P; Bryl, W; Cymerys, M; Kujawska-Łuczak, M; Miczke, A; Pupek-Musialik, D | 1 |
| Abdel-Rahman, AA; Li, G; Mao, L | 1 |
| Koss, MC | 1 |
| Ayan, F; Ikitimur, B; Koldas, L | 1 |
| Buranakitjaroen, P; Kittipawong, P; Koanantakul, B; Piamsomboon, C; Prasassarakich, N; Silaraks, S; Sukonthasarn, A; Tiyapant, A | 1 |
| Ernsberger, P; Koletsky, RJ; Velliquette, RA | 1 |
| Burgdorf, C; Engelhardt, A; Kurz, T; Raasch, W; Richardt, G; Schäfer, U | 1 |
| Bonisch, H; Bruss, M; Gothert, M; Molderings, GJ | 1 |
| Forzley, B; Penner, SB; Pirnat, D; Smyth, DD | 1 |
| Hefczyc, J; Konieczny, B; Kossmann, S; Szyguła, B; Szyguła, J | 1 |
| Bousquet, P; Greney, H; Monassier, L; Thomas, L | 1 |
| Abelson, KS; Höglund, AU | 1 |
| Meredith, PA; Reid, JL | 1 |
| Merwid-Lad, A; Misiuk-Hojło, M; Pieśniewska, M; Szaliński, M; Trocha, M | 1 |
| Dardonville, C; Rozas, I | 1 |
| de Arruda Camargo, LA; Guarda, IF; Guarda, RS; Saad, WA; Simões, S | 1 |
| Esler, M; Hastings, J; Jennings, G; Lambert, G; Lux, A; Socratous, F | 1 |
| Cohen, AF; de Visser, SJ; Schoemaker, RC; van der Post, JP; van Gerven, JM | 1 |
| Celik, A; Kaya, D; Kerpeten, K; Kilit, C; Onrat, E | 1 |
| Liebisch, B | 1 |
| Araújo, CV; Bousquet, P; Estato, V; Tibiriçá, E | 1 |
| Gerová, M; Matusková, J; Pecháòová, O; Török, J | 1 |
| Anichkov, DA; Schastnaya, OV; Shostak, NA | 1 |
| Abdel-Rahman, AA; Li, G; Wang, X | 2 |
| Caillé, S; Georges, F; Le Moine, C; Stinus, L; Vouillac, C | 1 |
| Adamczak, M; Nowak, Ł; Wiecek, A | 1 |
| Briaud, S; Sannajust, F; Zhang, BL | 1 |
| Kotanko, P | 1 |
| Ernsberger, P; Kossover, R; Previs, SF; Velliquette, RA | 1 |
| Bousquet, P; Feldman, J; Sy, GY | 1 |
| Czarnecka, D; Jaworski, R; Kawecka-Jaszcz, K; Klocek, M; Kucharska, M; Pachocki, R; Zabojszcz, M | 1 |
| Kasherininov, YR; Konrady, AO; Krutikov, AN; Shavarov, AA; Shavarova, EK; Shlyakhto, EV; Smirnova, EV; Vachrameeva, NV | 1 |
| Cong, B; Li, F; Li, J; Lu, XQ; Su, RB; Wu, N; Xu, B; Zheng, JQ | 1 |
| Catelli, MF; de Oliveira, MA; Moreira, PB; Nóbrega, AC; Rocha, NN; Teixeira de Castro, RR; Tibiriçá, E | 1 |
| Sirotiaková, J; Widimský, J | 1 |
| Alföldi, S; Elghozi, JL; Farsang, C; Finta, E; Laude, D | 1 |
| Khansefid, N; Ladgevardi, MA; Sabetkasaie, M | 1 |
| Abdel-Rahman, AA; Li, G | 1 |
| Sica, DA | 1 |
| Bousquet, PP; Monassier, LJ; Signolet, IL | 1 |
| Hayashi, Y; Iwasaki, M; Kamibayashi, T; Mashimo, T; Yamatodani, A | 1 |
| Avanza, AC; Mansur, AP; Ramires, JA | 1 |
| Gyires, K; Zádori, Z | 1 |
| Abdel-Rahman, AA; Bender, TS | 1 |
| Dolezal, T; Krsiak, M; Soukupová, M | 2 |
| Li, F; Li, J; Liu, Y; Lu, XQ; Su, RB; Wu, N | 1 |
| Al-Khrasani, M; Gyires, K; Mátyus, P; Mózes, MM; Pap, B; Shujaa, N; Zádori, ZS | 1 |
| Groenewoud, G; Meyer, B; Potgieter, L | 1 |
| Burke, SL; Evans, RG; Head, GA | 2 |
| Bousquet, P; Lessa, MA; Nascimento, AR; Sabino, B; Tibiriçá, E | 1 |
| Acevedo-Arozena, A; Brown, SD; Corrochano, S; Menzies, FM; Renna, M; Rose, C; Rubinsztein, DC; Sadiq, O | 1 |
| Chytil, L; Cvačka, J; Marešová, V; Slanař, O; Štícha, M; Štrauch, B; Widimský, J | 1 |
| Hayashi, Y; Iwasaki, M; Kamibayashi, T; Mashimo, T; Yamanaka, H; Yamatodani, A | 1 |
| Bakan, E; Borekci, B; Kumbasar, S; Kumtepe, Y; Salman, S; Suleyman, H; Yilmaz, M | 1 |
| Chen, CT; Cheng, JT; Cheng, KC; Lin, KC; Niu, CS; Wu, HT | 1 |
| Chen, CT; Cheng, JT; Chi, CW; Chung, HH; Wu, HT; Yang, PS; Yeh, CH | 1 |
| Bellinger, DL; Ghamsary, M; Kozic, B; Lorton, D; Lubahn, CL; Molinaro, CA; Perez, SD; Thyagarajan, S | 1 |
| Chen, MF; Cheng, JT; Chou, MT; Chung, HH; Yang, TT | 1 |
| Agbaba, D; Gemovic, B; Nikolic, K; Srdic-Rajic, T; Veljkovic, N | 1 |
| Al-Khrasani, M; Brancati, SB; Fehér, Á; Gyires, K; Hein, L; Lackó, E; Mátyus, P; Tóth, VE; Zádori, ZS | 1 |
| Cheng, J; Chung, HH | 1 |
| Davern, PJ; Head, GA; Jackson, KL; Nguyen-Huu, TP; Palma-Rigo, K | 1 |
| Lin, F; Qin, ZH | 1 |
| Eisenstein, M | 1 |
| Bento, CF; Deretic, V; Rubinsztein, DC | 1 |
| Cavic, M; Djokic, I; Gemovic, B; Nikolic, K; Perovic, V; Srdic-Rajic, T; Veljkovic, N | 1 |
| Bousquet, P; Gomes, F; Gonçalves-de-Albuquerque, CF; Lessa, MA; Machado, MV; Nascimento, AR; Tibiriçá, E; Vieira, AB | 1 |
| Agbaba, D; Azzali, E; Costantino, G; Glisic, S; Laurila, JM; Nikolic, K; Perovic, V; Pieroni, M; Radi, M; Scheinin, M; Srdic-Rajic, T; Tassini, S; Veljkovic, N; Vucicevic, J | 1 |
| Burke, SL; Head, GA; Jackson, KL; Lim, K | 1 |
| Beart, PM; Higgins, GC; Lau, CL; Lawrence, AJ; Mercer, LD | 1 |
| Barker, RA; Green-Thompson, ZW; Griffin, J; Jones, PS; Lazic, SE; Mason, SL; Pugh, PJ; Rowe, JB; Rubinsztein, DC; Underwood, BR | 1 |
49 review(s) available for oxazoles and rilmenidine
| Article | Year |
|---|---|
[Imidazole receptors: site of action of a new generation of antihypertensive drugs. Current status and future prospects].
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Binding Sites; Cattle; Humans; Imidazoles; Oxazoles; Rats; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1992 |
Imidazoline receptors. A new concept in central regulation of the arterial blood pressure.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Hypertension; Imidazoline Receptors; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1992 |
Distinctive features of rilmenidine possibly related to its selectivity for imidazoline receptors.
Topics: Adrenergic alpha-Agonists; Animals; Chickens; Dogs; Humans; Hypertension; Imidazoline Receptors; Mice; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1992 |
Rilmenidine: a novel approach to first-line treatment of hypertension.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Oxazoles; Rilmenidine | 1992 |
Clinical pharmacology of imidazolines and related compounds.
Topics: Adrenergic alpha-Agonists; Humans; Imidazoles; Oxazoles; Rilmenidine | 1992 |
[Current data on the pharmacology of rilmenidine].
Topics: Animals; Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Hypnotics and Sedatives; Oxazoles; Rilmenidine; Sympathetic Nervous System | 1989 |
New concepts on the central regulation of blood pressure. Alpha 2-adrenoceptors and "imidazoline receptors".
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Blood Pressure; Brain; Clonidine; Humans; Imidazoles; Oxazoles; Receptors, Adrenergic, alpha; Rilmenidine | 1989 |
Recent advances in the pharmacology of rilmenidine.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brain; Hemodynamics; Oxazoles; Peripheral Nerves; Rilmenidine; Sympatholytics | 1989 |
Rilmenidine: a novel antihypertensive agent.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Brain; Humans; Hypertension; Oxazoles; Rilmenidine; Wakefulness | 1989 |
Bronchial effects of alpha 2-adrenoceptor agonists and of other antihypertensive agents in asthma.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Asthma; Bronchi; Calcium Channel Blockers; Clonidine; Humans; Hypertension; Oxazoles; Rilmenidine | 1989 |
Rilmenidine and vigilance. Review of clinical studies.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Arousal; Blood Pressure; Double-Blind Method; Humans; Hypertension; Oxazoles; Random Allocation; Rilmenidine; Wakefulness | 1989 |
Newer antihypertensive drugs.
Topics: Antihypertensive Agents; Dibenzothiepins; Humans; Imidazoles; Methionine; Oxazoles; Piperazines; Protease Inhibitors; Rilmenidine | 1995 |
Importance of imidazoline receptors in the cardiovascular actions of centrally acting antihypertensive agents.
Topics: Adrenergic alpha-2 Receptor Agonists; Agmatine; Animals; Antihypertensive Agents; Baroreflex; Female; Imidazoline Receptors; Kidney; Male; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1995 |
Rilmenidine and the high risk hypertensive patient.
Topics: Animals; Antihypertensive Agents; Humans; Hypertension; Kidney; Oxazoles; Renin; Rilmenidine; Risk Factors; Sympathetic Nervous System | 1995 |
Clinical pharmacology of drugs acting on imidazoline and adrenergic receptors. Studies with clonidine, moxonidine, rilmenidine, and atenolol.
Topics: Antihypertensive Agents; Atenolol; Clinical Trials as Topic; Clonidine; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Placebos; Receptors, Adrenergic; Receptors, Drug; Reference Values; Rilmenidine | 1995 |
Protection of focal ischemic infarction by rilmenidine in the animal: evidence that interactions with central imidazoline receptors may be neuroprotective.
Topics: Adrenergic alpha-Agonists; Animals; Brain Ischemia; Cerebral Infarction; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; Neurons; Neuroprotective Agents; Oxazoles; Receptors, Drug; Rilmenidine | 1994 |
The high-risk hypertensive patient and the potential for brain imidazoline receptor binding by rilmenidine.
Topics: Animals; Brain; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine; Risk Factors | 1994 |
[Imidazole receptors and blood pressure regulation. High receptor selectivity of moxonidine].
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Cats; Clonidine; Humans; Hypertension; Imidazoles; Oxazoles; Rabbits; Rats; Receptors, Drug; Rilmenidine | 1993 |
[The imidazoline receptor and the central regulation of arterial pressure].
Topics: Blood Pressure; Catecholamines; Central Nervous System; Clonidine; Humans; Hypertension; Imidazoline Receptors; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1993 |
[Imidazol receptor agonists--new possibilities for treating hypertension].
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Hemodynamics; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1995 |
Imidazoline receptor agonist drugs: a new approach to the treatment of systemic hypertension.
Topics: Animals; Antihypertensive Agents; Clinical Trials as Topic; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1996 |
From alpha and beta to I1: an overview of sympathetic receptors involved in blood pressure control targets for drug treatment.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Receptors, Drug; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Rilmenidine | 1996 |
[Imidazoline receptors and use of drug blocking receptors I1].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Antihypertensive Agents; Arrhythmias, Cardiac; Cimetidine; Histamine H2 Antagonists; Humans; Hypertension; Imidazoles; Myocardial Infarction; Oxazoles; Rilmenidine | 1996 |
The imidazoline receptor in control of blood pressure by clonidine and allied drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Humans; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Neurons; Oxazoles; Receptors, Drug; Rilmenidine | 1997 |
Central imidazoline (I1) receptors as targets of centrally acting antihypertensives: moxonidine and rilmenidine.
Topics: Animals; Antihypertensive Agents; Brain; Humans; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1997 |
Sympatho-adrenal mechanisms regulating cardiovascular hypertrophy in primary hypertension: a role for rilmenidine?
Topics: Adrenal Glands; Animals; Antihypertensive Agents; Blood Vessels; Cardiomegaly; Humans; Hypertension; Hypertrophy; Norepinephrine; Oxazoles; Rilmenidine; Sympathetic Nervous System | 1998 |
[Clinical pharmacology of hypotensive drugs acting on central imidazoline receptors].
Topics: Antihypertensive Agents; Clonidine; Drug Interactions; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1998 |
Central I1-imidazoline receptors as targets of centrally acting antihypertensive drugs. Clinical pharmacology of moxonidine and rilmenidine.
Topics: Animals; Antihypertensive Agents; Brain; Clinical Trials as Topic; Clonidine; Hemodynamics; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1999 |
[New, modern, centrally active antihypertensive agents in the treatment of essential hypertension].
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Imidazoles; Medulla Oblongata; Oxazoles; Rilmenidine | 1999 |
Drugs acting on imidazoline receptors: a review of their pharmacology, their use in blood pressure control and their potential interest in cardioprotection.
Topics: Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Clinical Trials as Topic; Heart Failure; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1999 |
[New perspectives in the treatment of hypertension: the contribution of rilmenidine].
Topics: Antihypertensive Agents; Humans; Hypertension; Oxazoles; Rilmenidine | 2000 |
Clinical benefits of rilmenidine.
Topics: Adult; Aged; Antihypertensive Agents; Clinical Trials as Topic; Humans; Hypertension; Insulin Resistance; Middle Aged; Multicenter Studies as Topic; Oxazoles; Rilmenidine | 2000 |
The contribution of I1-selective agents in the management of syndrome X.
Topics: Antihypertensive Agents; Humans; Imidazoline Receptors; Insulin Resistance; Microvascular Angina; Oxazoles; Receptors, Drug; Rilmenidine | 2000 |
Identification and characterization of I1 imidazoline receptors: their role in blood pressure regulation.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Humans; Imidazoline Receptors; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 2000 |
I1 imidazoline receptors in cardiovascular regulation: the place of rilmenidine.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Cardiovascular Physiological Phenomena; Humans; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 2000 |
The sympathetic system and hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Norepinephrine; Oxazoles; Rilmenidine; Sympathetic Nervous System | 2000 |
Rilmenidine: a clinical overview.
Topics: Albuminuria; Animals; Antihypertensive Agents; Diabetic Angiopathies; Humans; Hyperlipidemias; Hypertension; Hypertrophy, Left Ventricular; Insulin Resistance; Oxazoles; Rilmenidine; Treatment Outcome | 2000 |
Efficacy of rilmenidine, a selective I1 imidazoline receptor binding agent in diabetic hypertensive patients.
Topics: Antihypertensive Agents; Clinical Trials as Topic; Diabetic Angiopathies; Humans; Hypertension; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 2000 |
Metabolic effects of moxonidine and other centrally acting antihypertensives.
Topics: Animals; Antihypertensive Agents; Diabetes Complications; Humans; Hypertension; Imidazoles; Insulin Resistance; Metabolism; Oxazoles; Rilmenidine; Sympathetic Nervous System; Sympatholytics; Syndrome | 1999 |
I1 receptors, cardiovascular function, and metabolism.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Cardiovascular System; Clonidine; Humans; Hypertension; Imidazoline Receptors; Kidney; Oxazoles; Pancreas; Receptors, Drug; Rilmenidine; Treatment Outcome | 2001 |
Update on rilmenidine: clinical benefits.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Humans; Hypertension; Oxazoles; Rilmenidine; Risk Factors; Treatment Outcome | 2001 |
[Central nervous system as a target for the new antihypertensive agents].
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Autonomic Fibers, Preganglionic; Brain; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Oxazoles; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Sympatholytics | 1999 |
[Albarel (rilmenidin)--a selective I1 imidazole receptor agonist. Pharmacologic properties and experience in clinical use].
Topics: Antihypertensive Agents; Humans; Imidazoles; Oxazoles; Rilmenidine | 2003 |
Centrally acting imidazoline I1-receptor agonists: do they have a place in the management of hypertension?
Topics: Animals; Antihypertensive Agents; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 2001 |
Imidazoline binding sites and their ligands: an overview of the different chemical structures.
Topics: Amidines; Animals; Antihypertensive Agents; Binding Sites; Carbolines; Guanidines; Humans; Imidazoles; Imidazoline Receptors; Ligands; Oxazoles; Receptors, Drug; Rilmenidine; Structure-Activity Relationship | 2004 |
Cause and consequences of sympathetic hyperactivity in chronic kidney disease.
Topics: Adrenergic alpha-Agonists; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Arginine; Brain Stem; Humans; Hyperkinesis; Hypertension, Renal; Imidazoles; Kidney Failure, Chronic; Nitric Oxide Synthase; Oxazoles; Receptor, Angiotensin, Type 1; Renal Dialysis; Rilmenidine; Sympathetic Nervous System; Sympatholytics | 2006 |
Centrally acting antihypertensive agents: an update.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Clonidine; Contraindications; Guanabenz; Guanfacine; Humans; Hypertension; Imidazoles; Methyldopa; Oxazoles; Rilmenidine | 2007 |
Degradation of misfolded proteins by autophagy: is it a strategy for Huntington's disease treatment?
Topics: Autophagy; Carbamazepine; Humans; Huntingtin Protein; Huntington Disease; Lithium; Mutant Proteins; Nerve Tissue Proteins; Oxazoles; Peptides; Rilmenidine; Sirolimus; Trehalose; Trinucleotide Repeat Expansion; Valproic Acid | 2013 |
Therapeutic targeting of autophagy in neurodegenerative and infectious diseases.
Topics: Autophagy; Communicable Diseases; Gene Expression Regulation; Humans; Models, Biological; Neurodegenerative Diseases; Oxazoles; Rilmenidine; Signal Transduction; Trehalose | 2015 |
59 trial(s) available for oxazoles and rilmenidine
| Article | Year |
|---|---|
[Treatment with rilmenidine 1 mg per day: time-lag to maximum response. A multicenter ambulatory study. Le Groupe Français d'étude Multicentrique d'Hyperium].
Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure Determination; Female; Humans; Hypertension; Male; Middle Aged; Oxazoles; Placebos; Rilmenidine | 1992 |
Clinical pharmacology of imidazolines and related compounds.
Topics: Adrenergic alpha-Agonists; Humans; Imidazoles; Oxazoles; Rilmenidine | 1992 |
The effects of two centrally-acting anti-hypertensive drugs on the quality of life.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Male; Methyldopa; Middle Aged; Oxazoles; Quality of Life; Rilmenidine | 1991 |
Antihypertensive drugs and baroreflex sensitivity. Effects of rilmenidine.
Topics: Adult; Antihypertensive Agents; Autonomic Nervous System; Blood Pressure; Double-Blind Method; Humans; Male; Nitroglycerin; Oxazoles; Phenylephrine; Pressoreceptors; Random Allocation; Reflex; Rilmenidine | 1989 |
[Effects of rilmenidine on the central nervous system and kidney].
Topics: Antihypertensive Agents; Central Nervous System; Humans; Hypertension; Kidney; Oxazoles; Rilmenidine; Time Factors | 1989 |
[Efficacy and acceptability of rilmenidine in mild to moderate arterial hypertension. A multicenter, randomized, double-blind trial, in comparison with methyldopa in 157 patients].
Topics: Adult; Antihypertensive Agents; Double-Blind Method; Female; Humans; Hypertension; Male; Methyldopa; Multicenter Studies as Topic; Oxazoles; Randomized Controlled Trials as Topic; Rilmenidine | 1989 |
[Multicenter, double-blind study comparing rilmenidine 1 mg and hydrochlorothiazide 25 mg in 244 patients].
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Multicenter Studies as Topic; Oxazoles; Rilmenidine; Time Factors | 1989 |
[Effects of rilmenidine on arterial parameters in essential arterial hypertension].
Topics: Antihypertensive Agents; Arm; Blood Pressure; Double-Blind Method; Hemodynamics; Humans; Hypertension; Middle Aged; Oxazoles; Pulsatile Flow; Randomized Controlled Trials as Topic; Rilmenidine; Vascular Resistance | 1989 |
Renal excretory actions of antihypertensive agents. Effects of rilmenidine.
Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Diuretics; Double-Blind Method; Drug Interactions; Electrolytes; Humans; Hydrochlorothiazide; Kidney; Male; Oxazoles; Rilmenidine; Vasodilator Agents | 1989 |
Rilmenidine and vigilance. Review of clinical studies.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Arousal; Blood Pressure; Double-Blind Method; Humans; Hypertension; Oxazoles; Random Allocation; Rilmenidine; Wakefulness | 1989 |
Effort blood pressure control in the course of antihypertensive treatment.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Double-Blind Method; Exercise Test; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Oxazoles; Physical Exertion; Random Allocation; Rest; Rilmenidine | 1989 |
Alpha 2-adrenoceptor agonists stimulate growth hormone secretion but have no acute effects on plasma cortisol under basal conditions.
Topics: Adrenergic alpha-Agonists; Adult; Clonidine; Growth Hormone; Humans; Hydrocortisone; Male; Oxazoles; Rilmenidine | 1987 |
Dose and concentration-effect relations for rilmenidine.
Topics: Administration, Oral; Adolescent; Adrenergic alpha-Agonists; Adult; Blood Pressure; Dose-Response Relationship, Drug; Female; Heart Rate; Humans; Hypertension; Hypnotics and Sedatives; Male; Oxazoles; Rilmenidine; Saliva; Secretory Rate; Xerostomia | 1988 |
Efficacy and acceptability of rilmenidine for mild to moderate systemic hypertension.
Topics: Adrenergic beta-Agonists; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Oxazoles; Random Allocation; Rilmenidine; Xerostomia | 1988 |
A multicenter double-blind comparative study of rilmenidine and clonidine in 333 hypertensive patients.
Topics: Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Clinical Trials as Topic; Clonidine; Double-Blind Method; Female; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine | 1988 |
Antihypertensive efficacy and acceptability of rilmenidine in elderly hypertensive patients.
Topics: Adrenergic alpha-Agonists; Aged; Aged, 80 and over; Blood Pressure; Clinical Trials as Topic; Female; Humans; Hypertension; Male; Methyldopa; Oxazoles; Patient Compliance; Random Allocation; Rilmenidine; Supination | 1988 |
Efficacy and safety of rilmenidine for arterial hypertension.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Therapy, Combination; Eye; Female; Glucose; Humans; Hypertension; Lipid Metabolism; Male; Middle Aged; Oxazoles; Random Allocation; Rilmenidine | 1988 |
Comparative effects of rilmenidine and clonidine on bronchial responses to histamine in asthmatic subjects.
Topics: Adrenergic alpha-Agonists; Adult; Asthma; Bronchi; Clonidine; Female; Forced Expiratory Volume; Histamine; Humans; Male; Oxazoles; Rilmenidine | 1988 |
Preliminary clinical pharmacological studies of S3341, a new hypotensive agent, and comparison with clonidine in normal males.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Blood Pressure; Central Nervous System; Clonidine; Dose-Response Relationship, Drug; Electrocardiography; Humans; Male; Oxazoles; Rilmenidine | 1984 |
Effects of one-year treatment with rilmenidine on systemic hypertension-induced left ventricular hypertrophy in hypertensive patients.
Topics: Antihypertensive Agents; Atrial Natriuretic Factor; Echocardiography; Female; Forearm; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Oxazoles; Renin; Rilmenidine; Vascular Resistance | 1994 |
Pharmacokinetics of rilmenidine in patients with chronic renal insufficiency and in hemodialysis patients.
Topics: Adolescent; Adult; Aged; Antihypertensive Agents; Creatinine; Dialysis Solutions; Female; Humans; Hypertension; Kidney; Kidney Failure, Chronic; Male; Middle Aged; Oxazoles; Renal Dialysis; Rilmenidine; Single-Blind Method | 1994 |
Efficacy and safety of rilmenidine in elderly patients--comparison with hydrochlorothiazide. The Belgian Multicentre Study Group.
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Double-Blind Method; Female; Humans; Hydrochlorothiazide; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine | 1994 |
Long-term control of blood pressure by rilmenidine in high-risk populations.
Topics: Age Factors; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine; Risk Factors | 1994 |
Dose-effect relationship of rilmenidine after chronic administration.
Topics: Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine; Supine Position | 1993 |
Double-blind controlled study of rilmenidine versus hydrochlorothiazide in mild hypertension: clinical and renal haemodynamic evaluation.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Creatinine; Double-Blind Method; Female; Glomerular Filtration Rate; Hemodynamics; Humans; Hydrochlorothiazide; Hypertension; Iodine Radioisotopes; Kidney; Male; Middle Aged; Oxazoles; Regional Blood Flow; Rilmenidine; Time Factors; Vascular Resistance | 1993 |
[Pharmaco-epidemiologic evaluation of rilmenidine in 18,235 hypertensive patients].
Topics: Adult; Aged; Antihypertensive Agents; Drug Administration Schedule; Female; Follow-Up Studies; Heart Rate; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine | 1995 |
Cardiovascular variability after rilmenidine challenge: assessment of acute dosing effects by means of spectral analysis.
Topics: Adult; Analysis of Variance; Antihypertensive Agents; Blood Pressure; Blood Pressure Determination; Cross-Over Studies; Double-Blind Method; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine | 1995 |
Rilmenidine in patients with left ventricular hypertrophy: beyond the reduction of left ventricular mass.
Topics: Antihypertensive Agents; Atrial Natriuretic Factor; Drug Administration Schedule; Electrolytes; Female; Heart Ventricles; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Oxazoles; Renin; Rilmenidine | 1995 |
Lipid profile and antihypertensive efficacy in hyperlipidemic hypertensive patients: comparison of rilmenidine and captopril.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Captopril; Double-Blind Method; Female; Humans; Hyperlipoproteinemia Type II; Hypertension; Lipids; Male; Middle Aged; Oxazoles; Rilmenidine | 1995 |
Comparative effects of rilmenidine and atenolol on tests of autonomic function and mental and dynamic exercise in patients with essential hypertension.
Topics: Adult; Anti-Arrhythmia Agents; Antihypertensive Agents; Atenolol; Autonomic Nervous System; Blood Pressure; Cross-Over Studies; Double-Blind Method; Exercise Test; Heart Rate; Humans; Hypertension; Male; Mental Processes; Middle Aged; Neurosecretory Systems; Oxazoles; Rilmenidine | 1995 |
Effects of rilmenidine and clonidine on the electroencephalogram, saccadic eye movements, and psychomotor function.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Clonidine; Cross-Over Studies; Double-Blind Method; Electroencephalography; Evoked Potentials, Auditory; Heart Rate; Humans; Male; Oxazoles; Placebos; Psychomotor Performance; Rilmenidine; Saccades | 1995 |
The effects of rilmenidine and atenolol on mental stress, dynamic exercise and autonomic function in mild to moderate hypertension.
Topics: Adrenergic beta-Antagonists; Adult; Antihypertensive Agents; Atenolol; Blood Pressure; Cross-Over Studies; Double-Blind Method; Exercise; Heart Rate; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine; Stress, Psychological; Supine Position | 1995 |
[Effects of rilmenidine (hyperium) on lipid balance in hyperlipidemic hypertensive patients. Randomized, controlled, double-blind 8-week study vs. captopril in parallel groups].
Topics: Antihypertensive Agents; Captopril; Double-Blind Method; Female; Humans; Hypercholesterolemia; Hyperlipidemias; Hypertension; Lipids; Male; Middle Aged; Oxazoles; Rilmenidine; Time Factors | 1996 |
Effect of N-dicyclopropylmethyl-amino-2-oxazoline (S-3341) on antioxidant status and nitric oxide in hypertensive patients.
Topics: Adult; Aged; Antihypertensive Agents; Antioxidants; Blood Pressure; Catalase; Humans; Hypertension; Male; Malondialdehyde; Middle Aged; Nitrates; Nitric Oxide; Nitrites; Oxazoles; Rilmenidine; Vitamin E | 1998 |
[Rilmenidine in rosacea: a double-blind study versus placebo].
Topics: Adrenergic alpha-Agonists; Adult; Double-Blind Method; Drug Tolerance; Female; Flushing; Humans; Male; Middle Aged; Oxazoles; Placebos; Rilmenidine; Rosacea; Treatment Outcome | 1997 |
Regression of left ventricular hypertrophy in hypertensive patients after 1 year of treatment with rilmenidine: a double-blind, randomized, controlled (versus nifedipine) study.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Diastole; Double-Blind Method; Echocardiography; Electrocardiography, Ambulatory; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Nifedipine; Oxazoles; Rilmenidine; Treatment Outcome | 1998 |
[Essential arterial hypertension treated with rilmenidin : what dose for what patient?].
Topics: Antihypertensive Agents; Dose-Response Relationship, Drug; Humans; Hypertension; Oxazoles; Rilmenidine | 1999 |
Effects of rilmenidine on stress-induced peak blood pressure and renal function.
Topics: Adrenergic alpha-Agonists; Adult; Blood Pressure; Cardiovascular Diseases; Cross-Over Studies; Double-Blind Method; Exercise Test; Humans; Kidney; Kidney Function Tests; Lithium; Male; Oxazoles; Placebos; Rilmenidine; Sodium; Stress, Psychological; Time Factors | 1999 |
Efficacy of rilmenidine versus captopril on microalbuminuria: a pilot study in hypertensive type 2 diabetics.
Topics: Albuminuria; Antihypertensive Agents; Captopril; Diabetes Mellitus, Type 2; Humans; Hypertension; Oxazoles; Pilot Projects; Random Allocation; Rilmenidine | 1999 |
Rilmenidine in the hypertensive type-2 diabetic: a controlled pilot study versus captopril.
Topics: Aged; Albuminuria; Antihypertensive Agents; Blood Pressure Determination; Captopril; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Oxazoles; Pilot Projects; Rilmenidine | 2000 |
Haemodynamic and metabolic effects of rilmenidine in hypertensive patients with metabolic syndrome X. A double-blind parallel study versus amlodipine.
Topics: Adult; Aged; Amlodipine; Antihypertensive Agents; Blood Glucose; Body Weight; Double-Blind Method; Female; Hemodynamics; Humans; Hypertension; Hypertriglyceridemia; Insulin; Male; Middle Aged; Oxazoles; Plasminogen Activator Inhibitor 1; Rilmenidine; Tissue Plasminogen Activator | 2000 |
Concentration-effect relationships of two infusion rates of the imidazoline antihypertensive agent rilmenidine for blood pressure and development of side-effects in healthy subjects.
Topics: Adult; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Electroencephalography; Female; Heart Rate; Humans; Infusions, Intravenous; Male; Oxazoles; Pain Measurement; Rilmenidine; Saccades; Salivary Glands | 2001 |
Effect of the new centrally acting antihypertensive agent rilmenidine on endothelial and platelet function in essential hypertension.
Topics: Adult; Aged; Antihypertensive Agents; Blood Platelets; Blood Pressure; Endothelium, Vascular; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine; Time Factors; Treatment Outcome | 2002 |
Concentration-effect relationships of two rilmenidine single-dose infusion rates in hypertensive patients.
Topics: Adult; Aged; Analysis of Variance; Confidence Intervals; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Hemodynamics; Humans; Hypertension; Infusions, Intravenous; Least-Squares Analysis; Male; Middle Aged; Oxazoles; Rilmenidine; Salivation | 2002 |
[Efficacy and tolerance of rilmenidine in patients with mild to moderate hypertension. Results of a Czech and Slovak 6-month multicenter study].
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Blood Pressure; Female; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine; Risk Factors | 2002 |
[Efficacy and acceptability of rilmenidine in a population of 2 738 hypertensive diabetic patients].
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Mass Index; Diabetes Complications; Diastole; Female; Follow-Up Studies; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine; Risk Factors; Time Factors | 2002 |
[Comparison of the antihypertensive efficacy of and tolerance to 2 imidazoline receptor agonists: moxonidine and rilmenidine in monotherapy].
Topics: Antihypertensive Agents; Female; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Male; Middle Aged; Oxazoles; Receptors, Drug; Rilmenidine; Severity of Illness Index | 2001 |
[The effect of analysed hypotensive drugs on certain metabolic parameters].
Topics: Adult; Antihypertensive Agents; Diabetes Mellitus, Type 2; Felodipine; Female; Humans; Hyperlipidemias; Hypertension; Hyperuricemia; Indoles; Male; Metabolic Syndrome; Middle Aged; Oxazoles; Rilmenidine | 2003 |
Efficacy and safety of rilmenidine, a selective imidazoline I1 receptor binding ligand, in mild-to-moderate Thai hypertensive patients.
Topics: Adult; Antihypertensive Agents; Female; Humans; Hypertension; Imidazoline Receptors; Ligands; Male; Middle Aged; Oxazoles; Receptors, Drug; Rilmenidine; Thailand; Treatment Outcome | 2003 |
Rilmenidine sympatholytic activity preserves mental stress, orthostatic sympathetic responses and adrenaline secretion.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Epinephrine; Female; Humans; Hypertension; Male; Middle Aged; Norepinephrine; Oxazoles; Posture; Rilmenidine; Stress, Psychological; Sympathetic Nervous System; Sympatholytics; Tilt-Table Test | 2004 |
Pharmacokinetic/pharmacodynamic assessment of tolerance to central nervous system effects of a 3 mg sustained release tablet of rilmenidine in hypertensive patients.
Topics: Administration, Oral; Adult; Aged; Antihypertensive Agents; Delayed-Action Preparations; Drug Administration Schedule; Drug Tolerance; Female; Humans; Hypertension; Male; Middle Aged; Oxazoles; Pain Measurement; Psychometrics; Reaction Time; Rilmenidine; Saccades; Tablets; Time Factors | 2004 |
[The effects of rilmenidine on cardiac autonomic function in healthy volunteers].
Topics: Adult; Antihypertensive Agents; Autonomic Nervous System; Cardiovascular Physiological Phenomena; Cross-Over Studies; Double-Blind Method; Heart Rate; Humans; Male; Oxazoles; Rilmenidine | 2004 |
Comparison of rilmenidine and lisinopril on ambulatory blood pressure and plasma lipid and glucose levels in hypertensive women with metabolic syndrome.
Topics: Adult; Aged; Analysis of Variance; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Glucose; Blood Pressure Monitoring, Ambulatory; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Lisinopril; Metabolic Syndrome; Middle Aged; Oxazoles; Prospective Studies; Rilmenidine; Single-Blind Method; Statistics, Nonparametric; Treatment Outcome | 2005 |
Blockade of sympathetic nervous system activity by rilmenidine increases plasma adiponectin concentration in patients with essential hypertension.
Topics: Adiponectin; Adult; Antihypertensive Agents; Blood Glucose; Blood Pressure; Female; Humans; Hypertension; Insulin; Male; Middle Aged; Oxazoles; Rilmenidine; Sympathetic Nervous System; Time Factors; Treatment Outcome | 2005 |
Rilmenidine--its antihypertensive efficacy, safety and impact on quality of life in perimenopausal women with mild to moderate essential hypertension.
Topics: Antihypertensive Agents; Blood Pressure; Female; Heart Rate; Humans; Hypertension; Middle Aged; Oxazoles; Perimenopause; Prospective Studies; Quality of Life; Rilmenidine | 2006 |
How can we block sympathetic overactivity? Effects of rilmenidine and atenolol in overweight hypertensive patients.
Topics: Adult; Analysis of Variance; Antihypertensive Agents; Area Under Curve; Atenolol; Brachial Artery; Echocardiography; Female; Glucose Tolerance Test; Humans; Hypertension; Lipids; Male; Middle Aged; Overweight; Oxazoles; Rilmenidine; Statistics, Nonparametric; Sympathetic Nervous System; Treatment Outcome | 2006 |
Reduced hemodynamic responses to physical and mental stress under low-dose rilmenidine in healthy subjects.
Topics: Administration, Oral; Adult; Antihypertensive Agents; Blood Pressure; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Exercise; Exercise Test; Exercise Tolerance; Female; Heart Rate; Hemodynamics; Humans; Male; Middle Aged; Oxazoles; Physical Fitness; Rilmenidine; Stress, Psychological | 2006 |
Efficacy of exercise, losartan, enalapril, atenolol and rilmenidine in subjects with blood pressure hyperreactivity at treadmill stress test and left ventricular hypertrophy.
Topics: Adult; Antihypertensive Agents; Atenolol; Blood Pressure; Enalapril; Exercise Test; Exercise Therapy; Female; Humans; Hypertrophy, Left Ventricular; Losartan; Male; Oxazoles; Renin-Angiotensin System; Rilmenidine; Sympathetic Nervous System | 2009 |
Bioequivalence evaluation of rilmenidine in healthy volunteers.
Topics: Adolescent; Adult; Antihypertensive Agents; Area Under Curve; Biological Availability; Chemistry, Pharmaceutical; Cross-Over Studies; Female; Humans; Male; Oxazoles; Rilmenidine; Therapeutic Equivalency; Young Adult | 2009 |
235 other study(ies) available for oxazoles and rilmenidine
| Article | Year |
|---|---|
Do centrally-acting antihypertensive drugs act at non-adrenergic as well as alpha-2 adrenoceptor sites?
Topics: Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Brain; Cisterna Magna; Clonidine; Guanabenz; Heart Rate; Infusion Pumps; Injections; Male; Osmosis; Oxazoles; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Rilmenidine | 1992 |
Reduction in focal cerebral ischemia by agents acting at imidazole receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Brain; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Ischemic Attack, Transient; Male; Neurons; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine | 1992 |
Nature of [3H]rilmenidine binding to membranes of rat cerebral cortex.
Topics: Adrenergic alpha-Agonists; Amiloride; Animals; Binding Sites; Catecholamines; Cell Membrane; Cerebral Cortex; Guanidine; Guanidines; Imidazoles; Oxazoles; Prazosin; Rats; Receptors, Adrenergic; Rilmenidine; Tritium; Yohimbine | 1992 |
Sympathoinhibitory effects of rilmenidine may be mediated by sites located below the brainstem.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Blood Pressure; Brain Stem; Heart Rate; Injections, Intraventricular; Kidney; Male; Oxazoles; Pentobarbital; Rats; Rats, Inbred SHR; Rilmenidine; Spinal Cord; Sympathetic Nervous System; Sympatholytics | 1992 |
Influence of anaesthesia on the cardiovascular effects of rilmenidine and clonidine in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Blood Pressure; Clonidine; Heart Rate; Hemodynamics; Injections, Intravenous; Injections, Intraventricular; Male; Oxazoles; Pentobarbital; Rats; Rats, Inbred SHR; Reflex; Rilmenidine; Sympathetic Nervous System | 1992 |
Importance of imidazoline receptors in the cardiovascular responses to clonidine and rilmenidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Biogenic Monoamines; Brain Stem; Cardiovascular System; Clonidine; Consciousness; Imidazoline Receptors; Neurotransmitter Agents; Oxazoles; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1992 |
Does rilmenidine act in vivo on central alpha 2-adrenoceptors modulating noradrenaline release?
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Hypothalamus; Norepinephrine; Oxazoles; Rats; Receptors, Adrenergic, alpha; Rilmenidine | 1992 |
Alpha 2-adrenoceptor and catecholamine-insensitive binding sites for [3H]rilmenidine in membranes from rat cerebral cortex.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Binding Sites; Catecholamines; Cerebral Cortex; In Vitro Techniques; Oxazoles; Rats; Receptors, Adrenergic, alpha; Rilmenidine | 1992 |
The effects of rilmenidine on tests of autonomic function in humans.
Topics: Adrenergic alpha-Agonists; Adult; Antihypertensive Agents; Autonomic Nervous System; Blood Pressure; Forearm; Heart Rate; Humans; Male; Oxazoles; Posture; Pressoreceptors; Reference Values; Regional Blood Flow; Rilmenidine; Valsalva Maneuver | 1992 |
Central cardiovascular effects of rilmenidine and neuropeptide Y in the conscious spontaneously hypertensive rat: haemodynamic and biochemical evidence for a negative interaction.
Topics: Adenylyl Cyclases; Adrenergic alpha-Agonists; Animals; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Hemodynamics; Hypertension; In Vitro Techniques; Male; Medulla Oblongata; Neuropeptide Y; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine | 1992 |
Inhibition of nitric oxide synthesis increases focal ischemic infarction in rat.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Antihypertensive Agents; Arginine; Cerebral Infarction; Ischemic Attack, Transient; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Oxazoles; Phenylephrine; Rats; Rats, Inbred WKY; Rilmenidine | 1992 |
Rilmenidine lowers arterial pressure via imidazole receptors in brainstem C1 area.
Topics: Animals; Antihypertensive Agents; Benzazepines; Binding, Competitive; Blood Pressure; Brain Stem; Clonidine; Decerebrate State; Dose-Response Relationship, Drug; Heart Rate; Imidazoline Receptors; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1991 |
Selectivity of rilmenidine for the nucleus reticularis lateralis, a ventrolateral medullary structure containing imidazoline-preferring receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Azepines; Blood Pressure; Catecholamines; Clonidine; Dioxanes; Electrochemistry; Hemodynamics; Idazoxan; Imidazoline Receptors; Male; Medulla Oblongata; Neurons; Oxazoles; Piperoxan; Rats; Rats, Inbred WKY; Receptors, Drug; Reticular Formation; Rilmenidine; Stereotaxic Techniques; Yohimbine | 1991 |
The imidazoline-guanidinium receptor site, a target for some alpha-2 adrenergic agonists, is involved in inhibition of Na(+)-H+ exchange in renal proximal tubule cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Carrier Proteins; Dioxanes; Hydrogen; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Ion Exchange; Kidney Tubules, Proximal; Oxazoles; Quinoxalines; Rabbits; Receptors, Drug; Rilmenidine; Sodium; Sodium-Hydrogen Exchangers | 1991 |
Effects of swim training alone and in combination with clonidine and rilmenidine on blood pressure, plasma electrolytes, vasopressin, and renin activity in spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Body Weight; Clonidine; Electrolytes; Heart; Male; Organ Size; Oxazoles; Physical Conditioning, Animal; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin; Rilmenidine; Swimming; Vasopressins | 1990 |
Importance of central noradrenergic and serotonergic pathways in the cardiovascular actions of rilmenidine and clonidine.
Topics: 5,6-Dihydroxytryptamine; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Brain; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Male; Norepinephrine; Oxazoles; Oxidopamine; Rabbits; Rilmenidine; Serotonin | 1991 |
Regional hemodynamic effects of rilmenidine and clonidine in the conscious spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Male; Oxazoles; Rats; Rats, Inbred SHR; Renal Circulation; Rilmenidine; Splanchnic Circulation | 1991 |
Electrophysiological effects of intravenous rilmenidine in man.
Topics: Administration, Oral; Adult; Aged; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Humans; Infusions, Intravenous; Male; Middle Aged; Oxazoles; Rilmenidine; Wolff-Parkinson-White Syndrome | 1991 |
Contractile reactivity of isolated resistance arteries after 4 weeks of treatment with rilmenidine, clonidine or hydralazine in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Arteries; Blood Pressure; Clonidine; Hydralazine; Hypertension; In Vitro Techniques; Male; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine; Time Factors; Vasoconstriction | 1991 |
Acute and chronic effects of rilmenidine on baroreflex function in conscious dogs.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Dogs; Female; Heart Rate; Male; Nitroglycerin; Oxazoles; Phenylephrine; Pressoreceptors; Reflex; Rilmenidine | 1990 |
[Selectivity of a new antihypertensive agent, rilmenidine, for imidazoline receptors in the human brain].
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Brain; Dioxanes; Humans; Idazoxan; Imidazoline Receptors; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Yohimbine | 1990 |
Desensitization and down-regulation of brain alpha 2-adrenoceptors by centrally acting antihypertensive drugs.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Brain; Central Nervous System; Clonidine; Down-Regulation; Guanabenz; Hemodynamics; In Vitro Techniques; Male; Oxazoles; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Yohimbine | 1990 |
Effect of imidazolines on Na+ transport and intracellular pH in renal proximal tubule cells.
Topics: Amiloride; Animals; Biological Transport; Brimonidine Tartrate; Cimetidine; Dioxanes; Dioxins; Hydrogen-Ion Concentration; Idazoxan; Imidazoles; In Vitro Techniques; Kidney Tubules, Proximal; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sodium | 1990 |
[The 1989 Bichat Conference. A new therapeutic orientation in arterial hypertension: the action of rilmenidine (Hyperium 1 mg) on the so-called imidazoline receptors].
Topics: Antihypertensive Agents; Humans; Hypertension; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1990 |
Evidence for the involvement of imidazoline receptors in the central hypotensive effect of rilmenidine in the rabbit.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain; Cisterna Magna; Dioxanes; Heart Rate; Hemodynamics; Idazoxan; Imidazoline Receptors; Injections; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Tissue Extracts; Yohimbine | 1990 |
Influence of the alpha-2 agonist oxaminozoline (S3341) on firing rate of central noradrenergic and serotonergic neurons in the rat. Comparison with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electrophysiology; Iontophoresis; Locus Coeruleus; Male; Neurons; Norepinephrine; Oxazoles; Prazosin; Raphe Nuclei; Rats; Rilmenidine; Serotonin; Yohimbine | 1986 |
Rapid eye movement sleep and the associated cardiovascular changes during and after continuous 10-day infusion of clonidine in normotensive rats: comparison with lofexidine and S3341.
Topics: Animals; Blood Pressure; Cardiovascular System; Clonidine; Drug Administration Schedule; Female; Heart Rate; Infusions, Intravenous; Oxazoles; Rats; Rats, Inbred Strains; Rilmenidine; Sleep, REM; Time Factors | 1987 |
[New discoveries in the regulation of arterial pressure: endazoline, rilmenidine and imidazoline receptors].
Topics: Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1989 |
[The heart in patients with hypertension: effects of rilmenidine on experimental cardiac hypertrophy of hypertensive origin in rats].
Topics: Animals; Antihypertensive Agents; Cardiomegaly; Collagen; Heart; Heart Failure; Hypertension; Nephrectomy; Oxazoles; Propranolol; Rats; Rats, Inbred Strains; Rilmenidine | 1989 |
[From alpha 2-adrenergic to endazoline receptors].
Topics: Animals; Antihypertensive Agents; Blood Pressure; Humans; Hypertension; Imidazoline Receptors; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1989 |
Rilmenidine selectivity for imidazoline receptors in human brain.
Topics: Adrenergic alpha-Agonists; Brain; Humans; Imidazoline Receptors; In Vitro Techniques; Nerve Tissue Proteins; Oxazoles; Receptors, Drug; Rilmenidine | 1989 |
Different affinities of alpha 2-agonists for imidazoline and alpha 2-adrenergic receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Dioxanes; Guanfacine; Guanidine; Guanidines; Idazoxan; Imidazoline Receptors; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine; Yohimbine | 1989 |
Rilmenidine differs from clonidine in that it lacks histamine-like activity.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Female; Guinea Pigs; Heart; Heart Rate; Histamine; In Vitro Techniques; Male; Myocardium; Oxazoles; Potassium Chloride; Rats; Rats, Inbred Strains; Receptors, Histamine H2; Rilmenidine; Uterine Contraction; Uterus | 1989 |
[Selectivity of alpha 2-adrenergic agonists for the imidazoline-guanidine and alpha 2-adrenergic receptors].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Guanfacine; Guanidines; Idazoxan; Kidney Tubules, Proximal; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Yohimbine | 1989 |
Cardiovascular effects of rilmenidine, a new alpha 2-adrenoceptor agonist, and clonidine in conscious spontaneously hypertensive rats.
Topics: Administration, Oral; Adrenergic alpha-Agonists; Animals; Blood Pressure; Catecholamines; Clonidine; Heart Rate; Hemodynamics; Injections, Intravenous; Male; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine | 1989 |
Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine.
Topics: Adrenergic alpha-Agonists; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Cardiomegaly; Desoxycorticosterone; Disease Models, Animal; Heart; Heart Rate; Hypertension; Male; Oxazoles; Propranolol; Rats; Rats, Inbred Strains; Rilmenidine; Sodium Chloride | 1989 |
[Interaction of rilmenidine with renal imidazoline-guanidine sites].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Basement Membrane; Binding Sites; Dioxanes; Drug Interactions; Guanfacine; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Male; Oxazoles; Phenylacetates; Rabbits; Receptors, Drug; Rilmenidine; Sodium Channels; Yohimbine | 1989 |
Second International Symposium on Rilmenidine. Paris, March 11, 1988. Proceedings.
Topics: Animals; Antihypertensive Agents; Humans; Hypertension; Oxazoles; Rilmenidine | 1989 |
Pharmacokinetics of rilmenidine.
Topics: Adult; Antihypertensive Agents; Biological Availability; Capsules; Carbon Radioisotopes; Female; Food; Humans; Male; Oxazoles; Rilmenidine; Solutions; Tablets | 1989 |
Treatment of hypertension in diabetic patients.
Topics: Antihypertensive Agents; Blood Glucose; Diabetes Complications; Diabetes Mellitus; Diuretics; Drug Therapy, Combination; Female; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine | 1989 |
Hypertension in the elderly.
Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Humans; Hypertension; Oxazoles; Rilmenidine | 1989 |
Acceptability of rilmenidine and long-term surveillance of plasma concentrations in hypertensive patients with renal insufficiency.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Heart Rate; Humans; Hypertension, Renal; Kidney; Kidney Failure, Chronic; Middle Aged; Oxazoles; Rilmenidine | 1989 |
Bistrifluoromethylaryl derivatives for drug analysis by gas chromatography electron capture negative ion chemical ionization mass spectrometry. Application to the measurement of (N-dicyclopropylmethyl)amino-2-oxazoline in plasma.
Topics: Adrenergic alpha-Agonists; Chemical Phenomena; Chemistry; Fluorobenzenes; Gas Chromatography-Mass Spectrometry; Humans; Oxazoles; Rilmenidine | 1985 |
Gas chromatographic negative ion mass spectrometric assay of 2-dicyclopropylmethylamino-2-oxazoline (S-3341), a new antihypertensive drug.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Chemical Phenomena; Chemistry; Gas Chromatography-Mass Spectrometry; Humans; Kinetics; Oxazoles; Rilmenidine | 1985 |
Central and peripheral effects of S 3341 [(N-dicyclopropylmethyl)-amino-2-oxazoline] in animal models.
Topics: Adrenergic alpha-Agonists; Animals; Binding, Competitive; Blood Pressure; Brain; Cats; Clonidine; Decerebrate State; Female; Heart Rate; Hexobarbital; In Vitro Techniques; Male; Mice; Oxazoles; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rilmenidine; Sleep; Time Factors | 1986 |
Quantitative analysis of S3341 in human plasma and urine by combined gas chromatography-negative ion chemical ionization mass spectrometry: 15 month inter-day precision and accuracy validation.
Topics: Adrenergic alpha-Agonists; Gas Chromatography-Mass Spectrometry; Humans; Oxazoles; Quality Control; Rilmenidine | 1987 |
A symposium: Rilmenidine--a novel alpha2 agonist antihypertensive agent.
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Humans; Oxazoles; Rilmenidine | 1988 |
Cardiovascular and central nervous system effects of rilmenidine (S 3341) in rats.
Topics: Adrenalectomy; Adrenergic alpha-Agonists; Anesthesia; Animals; Blood Pressure; Catecholamines; Central Nervous System; Chickens; Clonidine; Decerebrate State; Electric Stimulation; Heart Rate; Hemodynamics; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Reflex; Rilmenidine; Sleep | 1988 |
Action of rilmenidine on locus ceruleus and dorsal raphe cells in vivo and in vitro.
Topics: Action Potentials; Adrenergic alpha-Agonists; Animals; Clonidine; In Vitro Techniques; Infusions, Intravenous; Iontophoresis; Locus Coeruleus; Lysergic Acid Diethylamide; Male; Oxazoles; Prazosin; Raphe Nuclei; Rats; Rats, Inbred Strains; Rilmenidine | 1988 |
Effects of two alpha 2 agonists, rilmenidine and clonidine, on the morphine withdrawal syndrome and their potential addictive properties in rats.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Clonidine; Male; Morphine; Oxazoles; Rats; Rats, Inbred Strains; Rilmenidine; Substance Withdrawal Syndrome; Substance-Related Disorders | 1988 |
Effects of continuous infusions (10 days) and cessation of infusions of clonidine and rilmenidine (S 3341) on cardiovascular and behavioral parameters of spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Behavior, Animal; Blood Pressure; Clonidine; Female; Heart Rate; Infusion Pumps; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine; Sleep, REM; Time Factors | 1988 |
Effects of rilmenidine on bronchomotor responses in the guinea pig.
Topics: Adrenergic alpha-Agonists; Animals; Bronchi; Clonidine; Compliance; Drug Synergism; Guinea Pigs; Histamine; Male; Oxazoles; Rilmenidine | 1988 |
Pharmacokinetics of rilmenidine in healthy subjects.
Topics: Absorption; Administration, Oral; Adrenergic beta-Agonists; Biological Availability; Carbon Radioisotopes; Drug Administration Schedule; Eating; Female; Half-Life; Humans; Injections, Intravenous; Male; Oxazoles; Rilmenidine | 1988 |
Pharmacokinetics of rilmenidine.
Topics: Absorption; Administration, Oral; Adrenergic beta-Agonists; Adult; Aged; Aged, 80 and over; Female; Humans; Hypertension; Kidney Failure, Chronic; Liver Diseases; Male; Middle Aged; Oxazoles; Rilmenidine | 1988 |
Pharmacology of the alpha 2-adrenoceptor agonist rilmenidine.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Central Nervous System; Chemical Phenomena; Chemistry; Clonidine; Dose-Response Relationship, Drug; Hexobarbital; Humans; Hypnotics and Sedatives; Mice; Oxazoles; Rats; Rilmenidine; Sleep | 1988 |
Hemodynamic and electrophysiologic effects of a new alpha 2-adrenoceptor agonist, rilmenidine, for systemic hypertension.
Topics: Adrenergic beta-Agonists; Adult; Blood Pressure; Cardiac Output; Cardiac Pacing, Artificial; Electrocardiography; Electrophysiology; Female; Heart Conduction System; Heart Rate; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine; Stroke Volume; Time Factors | 1988 |
Noninvasive study of cardiac structure and function after rilmenidine for essential hypertension.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Blood Pressure; Echocardiography; Female; Heart; Hemodynamics; Humans; Hypertension; Male; Middle Aged; Myocardium; Oxazoles; Rilmenidine; Stroke Volume; Time Factors; Vascular Resistance | 1988 |
Treatment of systemic hypertension in insulin-treated diabetes mellitus with rilmenidine.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuminuria; Blood Pressure; Diabetes Mellitus, Type 1; Electrocardiography; Female; Glucose; Humans; Hypertension; Lipid Metabolism; Male; Middle Aged; Oxazoles; Proteinuria; Rilmenidine | 1988 |
Prejunctional alpha 2-adrenergic properties of S-3341 (dicyclopropylmethyl)amino-2-delta-2-oxazoline: a comparison with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Electric Stimulation; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Oxazoles; Prazosin; Rats; Rats, Inbred WKY; Rilmenidine; Vas Deferens; Yohimbine | 1987 |
Rilmenidine (S 3341) and the sympathoadrenal system: adrenoreceptors, plasma and adrenal catecholamines in dogs.
Topics: Adrenal Medulla; Adrenergic alpha-Agonists; Animals; Blood Flow Velocity; Blood Platelets; Blood Pressure; Catecholamines; Dogs; Heart Rate; Leukocytes; Oxazoles; Rilmenidine; Sympathetic Nervous System | 1988 |
Rilmenidine acts as a partial agonist at prejunctional alpha 2-adrenoceptors in guinea-pig atria.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Atrial Function; Electric Stimulation; Female; Guinea Pigs; Male; Norepinephrine; Oxazoles; Receptors, Adrenergic, alpha; Rilmenidine | 1988 |
Effect of the amino-oxazoline derivative S-3341 on pre- and postjunctional alpha-adrenoceptors in isolated blood vessels.
Topics: Animals; Clonidine; Dogs; In Vitro Techniques; Norepinephrine; Oxazoles; Perfusion; Phenylephrine; Prazosin; Pulmonary Artery; Rabbits; Receptors, Adrenergic, alpha; Rilmenidine; Saphenous Vein; Vasoconstriction; Yohimbine | 1986 |
Interaction of clonidine and rilmenidine with imidazoline-preferring receptors.
Topics: Animals; Binding, Competitive; Clonidine; Imidazoline Receptors; In Vitro Techniques; Kidney Tubules, Proximal; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1988 |
Use of hepatocyte cultures for preliminary metabolism and cytotoxicity studies of a new anti-hypertensive agent, oxaminozoline.
Topics: Animals; Antihypertensive Agents; Biotransformation; Cells, Cultured; Clonidine; Drug Evaluation, Preclinical; Endothelium; L-Lactate Dehydrogenase; Liver; Oxazoles; Rats; Rats, Inbred Strains; Rilmenidine; Serum Albumin | 1988 |
Rapid eye movement (REM)-sleep during and after continuous infusion of the oxazoline derivate S3341: a comparison with clonidine.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Female; Oxazoles; Rats; Rats, Inbred WKY; Rilmenidine; Sleep, REM; Time Factors | 1984 |
Clonidine and rilmenidine suppress hypotension-induced Fos expression in the lower brainstem of the conscious rabbit.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Clonidine; Consciousness; Female; Heart Rate; Hypotension; Immunohistochemistry; Male; Oxazoles; Proto-Oncogene Proteins c-fos; Rabbits; Rats; Rilmenidine; Tyrosine 3-Monooxygenase | 1995 |
Involvement of peripheral presynaptic inhibition in the reduction of sympathetic tone by moxonidine, rilmenidine and UK 14304.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Antihypertensive Agents; Brimonidine Tartrate; Decerebrate State; Dose-Response Relationship, Drug; Electric Stimulation; Female; Imidazoles; Male; Neural Inhibition; Oxazoles; Peripheral Nervous System; Presynaptic Terminals; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Vasoconstrictor Agents | 1995 |
Rilmenidine-induced hypotension in conscious rabbits involves imidazoline-preferring receptors.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Dioxanes; Dose-Response Relationship, Drug; Female; Heart Rate; Hypotension; Idazoxan; Imidazoline Receptors; Male; Methyldopa; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1994 |
Effects of three alpha 2-adrenoceptor agonists, rilmenidine, UK 14304 and clonidine on bradykinin- and substance P-induced airway microvascular leakage in guinea-pigs.
Topics: Acetylcholine; Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Bradykinin; Brimonidine Tartrate; Capillaries; Capillary Permeability; Clonidine; Dioxanes; Extravascular Lung Water; Guinea Pigs; Idazoxan; Oxazoles; Prazosin; Quinoxalines; Rilmenidine; Substance P; Trachea | 1995 |
Excess catecholamines and the metabolic syndrome: should central imidazoline receptors be a therapeutic target?
Topics: Animals; Antihypertensive Agents; Cardiovascular Diseases; Catecholamines; Energy Intake; Energy Metabolism; Humans; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Models, Biological; Neurons; Obesity; Oxazoles; Receptors, Drug; Rilmenidine; Social Conditions; Stress, Psychological; Sympathetic Nervous System | 1995 |
Distribution of nonadrenergic [3H]rilmenidine binding in rat brain and kidney.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoradiography; Binding Sites; Brain; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Kidney; Male; Oxazoles; Radioligand Assay; Rats; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Tritium | 1995 |
Effects of rilmenidine on signal transduction mechanisms associated with alpha 2-adrenergic and imidazoline receptors in brain.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Brain Stem; Calcium; Cerebral Cortex; Cyclic AMP; Cyclic GMP; Imidazoline Receptors; In Vitro Techniques; Ion Transport; Oxazoles; Phosphatidylinositols; Rats; Receptors, Drug; Rilmenidine; Rubidium; Signal Transduction | 1995 |
Rilmenidine alters renal function when administered intracerebroventricularly or intrarenally.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Drug Administration Routes; Imidazoline Receptors; Kidney; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Renal Artery; Rilmenidine | 1995 |
Evidence for a role for imidazoline I1 binding site in rat brown adipocytes.
Topics: Adipose Tissue, Brown; Animals; Carrier Proteins; Clonidine; Imidazoline Receptors; Ion Channels; Isoproterenol; Membrane Proteins; Mitochondria; Mitochondrial Proteins; Oxazoles; Oxygen; Rats; Rats, Wistar; Receptors, Drug; Rilmenidine; Uncoupling Protein 1 | 1995 |
Mechanism of sympathoinhibition by imidazolines.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzazepines; Brimonidine Tartrate; Dioxanes; Hemodynamics; Idazoxan; Imidazoles; Oxazoles; Quinoxalines; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1995 |
Sympathoinhibitory action of rilmenidine in conscious sinoaortically denervated rats.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cisterna Magna; Denervation; Dioxanes; Heart Rate; Idazoxan; Infusions, Intravenous; Injections; Injections, Intra-Arterial; Kidney; Male; Oxazoles; Phenylephrine; Rats; Rats, Wistar; Rilmenidine; Sinoatrial Node; Sympatholytics | 1993 |
Quantitative autoradiographic localization in rat brain of alpha 2-adrenergic and non-adrenergic I-receptor binding sites labelled by [3H]rilmenidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Autoradiography; Binding Sites; Brain; Brain Chemistry; Clonidine; Epinephrine; Imidazoline Receptors; Male; Oxazoles; Radioligand Assay; Rats; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1995 |
Central alpha-2 adrenoceptors are responsible for a clonidine-induced cue in a rat drug discrimination paradigm.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Clonidine; Conditioning, Operant; Cues; Discrimination, Psychological; Male; Oxazoles; Rats; Receptors, Adrenergic, alpha-2; Reinforcement Schedule; Reward; Rilmenidine | 1993 |
Differential patterns of local cerebral glucose utilisation associated with rilmenidine- or B-HT 933-induced hypotension.
Topics: Animals; Antihypertensive Agents; Autoradiography; Azepines; Brain; Glucose; Hypotension; Male; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine; Tissue Distribution | 1994 |
Stimulatory effects of clonidine, cirazoline and rilmenidine on locus coeruleus noradrenergic neurones: possible involvement of imidazoline-preferring receptors.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Locus Coeruleus; Male; Membrane Potentials; Neurons; Norepinephrine; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1993 |
Down-regulation of imidazoline sites in rabbit kidney.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Clonidine; Dioxanes; Down-Regulation; Guanabenz; Idazoxan; Imidazoline Receptors; Kidney; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 1993 |
Sympathoinhibition by rilmenidine in conscious rabbits: involvement of alpha 2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Catecholamines; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Electric Stimulation; Electrodes, Implanted; Female; Heart Rate; Hemodynamics; Idazoxan; Kidney; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1993 |
Molecular studies of alpha-2-adrenoceptor and catecholamine-insensitive imidazoline-receptor binding sites using [3H]-rilmenidine in rat brain and kidney.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Binding Sites; Brain; Catecholamines; Imidazoline Receptors; In Vitro Techniques; Kidney; Oxazoles; Rats; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Tissue Distribution | 1993 |
Differential receptors involved in the cardiovascular effects of clonidine and rilmenidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Clonidine; Dioxanes; Female; Idazoxan; Imidazoline Receptors; Male; Methyldopa; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1993 |
Effect of rilmenidine on baroreflex control of renal sympathetic nerve activity.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Baroreflex; Blood Pressure; Dioxanes; Female; Idazoxan; Imidazoline Receptors; Kidney; Male; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System | 1993 |
Is the sympathoinhibitory effect of rilmenidine mediated by alpha-2 adrenoceptors or imidazoline receptors?
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Blood Pressure; Brimonidine Tartrate; Dose-Response Relationship, Drug; Heart Rate; Imidazoline Receptors; Kidney; Oxazoles; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System | 1994 |
Imidazoline Receptors: A Novel Approach to Hypertension--the Contribution of Rilmenidine. Symposium proceedings. Milan, Italy, June 8, 1993.
Topics: Animals; Antihypertensive Agents; Humans; Hypertension; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1994 |
Natriuretic effect of rilmenidine in anesthetized rats.
Topics: Adrenergic alpha-Agonists; Adrenergic Fibers; Animals; Hemodynamics; Kidney; Natriuresis; Oxazoles; Rats; Rats, Wistar; Rilmenidine; Sodium; Thiopental | 1994 |
Involvement of imidazoline-preferring receptors in regulation of sympathetic tone.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Central Nervous System; Clonidine; Dioxanes; Dose-Response Relationship, Drug; Female; Hemodynamics; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Oxazoles; Rabbits; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine | 1994 |
Attenuated renal response to moxonidine and rilmenidine in one kidney-one clip hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Hemodynamics; Hypertension, Renovascular; Imidazoles; Infusions, Intra-Arterial; Kidney; Male; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Renal Circulation; Rilmenidine; Sodium; Urodynamics | 1994 |
A novel mechanism of action for hypertension control: moxonidine as a selective I1-imidazoline agonist.
Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Autoradiography; Binding Sites; Blood Pressure; Cattle; Cells, Cultured; Clonidine; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine | 1994 |
Renal effects of rilmenidine in anesthetized rats: importance of renal nerves.
Topics: Adrenergic alpha-Agonists; Anesthesia; Animals; Hemodynamics; Kidney; Male; Oxazoles; Rats; Rats, Wistar; Renal Circulation; Rilmenidine; Sympathectomy; Sympathetic Nervous System | 1993 |
Time-dependent efficacy of antihypertensive agents in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Captopril; Circadian Rhythm; Clonidine; Felodipine; Heart Rate; Hypertension; Labetalol; Male; Metoprolol; Oxazoles; Prazosin; Propanolamines; Propranolol; Rats; Rats, Inbred SHR; Rilmenidine; Thiophenes | 1993 |
Cardiac electrophysiological effects of rilmenidine, a novel antihypertensive agent, in the conscious dog: comparison with clonidine.
Topics: Animals; Antihypertensive Agents; Atrial Function; Blood Pressure; Clonidine; Dogs; Electrocardiography; Electrophysiology; Female; Heart; Heart Atria; Male; Oxazoles; Rilmenidine; Sinoatrial Node | 1994 |
Differential characteristics and localisation of [3H]oxazoline and [3H]imidazoline binding sites in rat kidney.
Topics: Adrenergic alpha-Antagonists; Animals; Autoradiography; Binding Sites; Dioxanes; Idazoxan; Imidazoles; Kidney; Male; Oxazoles; Radioligand Assay; Rats; Rats, Inbred WKY; Rilmenidine | 1995 |
Renal effects of infusion of rilmenidine and guanabenz in conscious dogs: contribution of peripheral and central nervous system alpha 2-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autonomic Nerve Block; Binding Sites; Blood Pressure; Central Nervous System; Consciousness; Dioxanes; Dogs; Dose-Response Relationship, Drug; Ganglia, Autonomic; Guanabenz; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney; Male; Oxazoles; Peripheral Nervous System; Receptors, Adrenergic, alpha-2; Receptors, Drug; Renal Circulation; Rilmenidine | 1995 |
Carotid arterial changes produced by a centrally mediated antihypertensive agent in hypertensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Blood Pressure; Cardiac Output; Carotid Arteries; Disease Models, Animal; Heart Rate; Hypertension; Injections, Intravenous; Oxazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rilmenidine; Vascular Resistance | 1995 |
Role of imidazoline receptors in the cardiovascular actions of moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1996 |
Imidazoline Receptors in a Comprehensive Approach to Hypertension. Proceedings of an international symposium. Berlin, Germany, September 10, 1994.
Topics: Animals; Antihypertensive Agents; Humans; Hypertension; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 1995 |
Rilmenidine prevents epinephrine-induced arrhythmias in halothane-anesthetized dogs.
Topics: Adrenergic alpha-Agonists; Anesthesia, Inhalation; Anesthetics, Inhalation; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Dogs; Dose-Response Relationship, Drug; Epinephrine; Female; Halothane; Imidazoline Receptors; Male; Oxazoles; Receptors, Drug; Rilmenidine | 1995 |
Brain structures involved in the hypotensive effects of rilmenidine: evaluation by [14C]2-deoxyglucose autoradiography.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Autoradiography; Azepines; Blood Pressure; Brain; Carbon Radioisotopes; Deoxyglucose; Glucose; Hypertension; Imidazoline Receptors; Male; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1995 |
Selectivity of rilmenidine for I1-imidazoline-binding sites in rabbit proximal tubule cells.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Binding Sites; Binding, Competitive; Cells, Cultured; Clonidine; Dioxanes; Idazoxan; Imidazoles; Imidazoline Receptors; Kidney Tubules, Proximal; Kinetics; Male; Oxazoles; Rabbits; Radioligand Assay; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Tritium | 1995 |
Renal I1-imidazoline receptor-selective compounds mediate natriuresis in the rat.
Topics: Adrenergic alpha-Agonists; Agmatine; Animals; Antihypertensive Agents; Imidazoline Receptors; Kidney; Male; Natriuresis; Oxazoles; Rats; Receptors, Drug; Rilmenidine; Urodynamics | 1995 |
Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Anesthetics, Inhalation; Animals; Arrhythmias, Cardiac; Blood Pressure; Dogs; Epinephrine; Female; Halothane; Heart Rate; Idazoxan; Imidazoline Receptors; Male; Oxazoles; Receptors, Drug; Rilmenidine; Yohimbine | 1996 |
Interactions of the cardiac chronotropic effects of rilmenidine with the autonomic nervous system in conscious dogs: comparison with clonidine.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Atropine; Blood Pressure; Chronic Disease; Clonidine; Depression, Chemical; Dogs; Female; Heart Block; Heart Rate; Male; Muscarinic Antagonists; Oxazoles; Phenoxybenzamine; Pindolol; Rilmenidine; Yohimbine | 1996 |
No evidence for functional imidazoline receptors on locus coeruleus neurons.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzazepines; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Locus Coeruleus; Male; Microelectrodes; Neurons; Oxazoles; Quinolines; Rats; Rats, Wistar; Receptors, Drug; Rilmenidine | 1996 |
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors | 1996 |
Rilmenidine activates postjunctional alpha 1- and alpha 2-adrenoceptors in the canine saphenous vein.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Brimonidine Tartrate; Calcium Channel Blockers; Clonidine; Dihydropyridines; Dogs; Female; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isotope Labeling; Male; Medetomidine; Muscle Contraction; Muscle, Smooth; Osmolar Concentration; Oxazoles; Phenoxybenzamine; Prazosin; Protein Binding; Quinoxalines; Radioligand Assay; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Tritium; Yohimbine | 1996 |
Rilmenidine-induced ocular hypotension: role of imidazoline1 and alpha 2 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Calcium; Ciliary Body; Cyclic AMP; Female; Imidazoles; Imidazoline Receptors; Intraocular Pressure; Iris; Male; Norepinephrine; Ocular Hypotension; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathectomy; Sympathetic Nervous System; Yohimbine | 1996 |
Rilmenidine and reflex renal sympathetic nerve activation in Wistar and hypertensive rats.
Topics: Animals; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Imidazoline Receptors; Kidney; Male; Oxazoles; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Drug; Reflex; Rilmenidine; Sympathetic Nervous System | 1996 |
Inhibition of centrally induced ventricular arrhythmias by rilmenidine and idazoxan in rabbits.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antihypertensive Agents; Arrhythmias, Cardiac; Bicuculline; Blood Pressure; Dose-Response Relationship, Drug; GABA Antagonists; Heart Rate; Idazoxan; Injections, Intravenous; Male; Oxazoles; Rabbits; Rilmenidine | 1996 |
[Effects of rilmenidine on rats made insulin resistant and hypertensive by a high fructose diet].
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Diabetes Mellitus, Experimental; Dietary Carbohydrates; Disease Models, Animal; Fructose; Hypertension; Insulin; Insulin Resistance; Oxazoles; Rats; Rats, Wistar; Rilmenidine | 1996 |
Are imidazoline receptors involved in sympathetic neurotransmission in rat vas deferens?
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Electric Stimulation; Idazoxan; Imidazoline Receptors; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Oxazoles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Yohimbine | 1996 |
Renal effects of rilmenidine in volume-loaded anaesthetized dogs.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Volume; Diuresis; Dogs; Hematocrit; Kidney; Male; Natriuresis; Oxazoles; Pentobarbital; Plasma Volume; Rilmenidine | 1997 |
Pretreatment with quinpirole inhibits the central antihypertensive effects of rilmenidine and alpha-methyldopa in conscious rats.
Topics: Animals; Antihypertensive Agents; Domperidone; Dopamine Agonists; Male; Methyldopa; Oxazoles; Quinpirole; Rats; Rats, Inbred SHR; Rilmenidine; Species Specificity; Vasopressins | 1997 |
The involvement of pertussis toxin-sensitive G proteins in the post receptor mechanism of central I1-imidazoline receptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; GTP-Binding Proteins; Imidazoles; Imidazoline Receptors; Male; Medetomidine; Oxazoles; Pertussis Toxin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Signal Transduction; Virulence Factors, Bordetella | 1997 |
Renal denervation altered the hemodynamic and renal effects following intracerebroventricular administration of the I1-imidazoline receptor agonist, rilmenidine, in pentobarbital anaesthetized rats.
Topics: Anesthesia; Animals; Blood Pressure; Denervation; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Imidazoline Receptors; Injections, Intraventricular; Kidney; Natriuresis; Osmolar Concentration; Oxazoles; Pentobarbital; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rilmenidine | 1997 |
Effect of rilmenidine on arterial pressure and urinary output in the spontaneously hypertensive rat.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Food Preferences; Heart Rate; Hypertension; Kidney; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine; Sodium Chloride; Urine | 1997 |
Cardiac vagal effects of rilmenidine in the dog: comparison with clonidine.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Clonidine; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Electrocardiography; Female; Heart; Heart Rate; In Vitro Techniques; Male; Oxazoles; Rilmenidine; Vagus Nerve | 1997 |
Effect of rilmenidine injection into the paraventricular nucleus of the hypothalamus on the water intake induced by application of angiotensin II to the subfornical organ.
Topics: Angiotensin II; Animals; Drinking; Idazoxan; Imidazoles; Injections; Male; Oxazoles; Paraventricular Hypothalamic Nucleus; Rats; Rats, Sprague-Dawley; Rilmenidine; Subfornical Organ | 1997 |
Role of I1 imidazoline receptors in the sympathoinhibition produced by intracisternally administered rilmenidine and moxonidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cisterna Magna; Dose-Response Relationship, Drug; Female; Guanabenz; Heart Rate; Imidazoles; Imidazoline Receptors; Injections; Male; Norepinephrine; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Yohimbine | 1997 |
Antagonism of alpha1-adrenoceptor agonist-induced responses by rilmenidine in vascular smooth muscle.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Calcium; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxazoles; Phenylephrine; Portal Vein; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Rilmenidine | 1998 |
Ethanol selectively counteracts hypotension evoked by central I(1)-imidazoline but not alpha2-adrenergic receptor activation in spontaneously hypertensive rats.
Topics: Animals; Blood Pressure; Brain; Clonidine; Ethanol; Heart Rate; Hypertension; Imidazoline Receptors; Male; Nordefrin; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 1998 |
Site and receptors involved in the sympathoinhibitory actions of rilmenidine.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Female; Imidazoline Receptors; Injections, Intraventricular; Kidney; Male; Neural Inhibition; Oxazoles; Rabbits; Receptors, Adrenergic, alpha; Receptors, Drug; Rilmenidine; Sympathetic Nervous System | 1998 |
Complementary antihypertensive action of rilmenidine on the pressure-natriuresis relationship and sodium preference in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Appetite; Blood Pressure; Hypertension; Natriuresis; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine; Sodium Chloride | 1998 |
Preventive effect of rilmenidine on the occurrence of neurogenic ventricular arrhythmias in rabbits.
Topics: Animals; Antihypertensive Agents; Bicuculline; Cardiac Complexes, Premature; GABA Antagonists; Hemodynamics; Idazoxan; Injections, Intravenous; Injections, Intraventricular; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Tachycardia, Ventricular | 1998 |
Rilmenidine normalizes fructose-induced insulin resistance and hypertension in rats.
Topics: Animals; Antihypertensive Agents; Blood Glucose; Blood Pressure; Fructose; Hypertension; Insulin Resistance; Kinetics; Lipids; Male; Oxazoles; Rats; Rats, Wistar; Reference Values; Rilmenidine | 1998 |
Rilmenidine elevates cytosolic free calcium concentration in suspended cerebral astrocytes.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Astrocytes; Calcium; Cells, Cultured; Cerebral Cortex; Cytosol; Endoplasmic Reticulum; Imidazoles; Oxazoles; Rats; Receptors, Adrenergic, alpha-2; Rilmenidine | 1998 |
Rilmenidine reveals differences in the pharmacological characteristics of prejunctional alpha2-adrenoceptors in the guinea-pig, rat and pig.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Arteries; Brimonidine Tartrate; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Ileum; Male; Muscle Contraction; Oxazoles; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Rilmenidine; Species Specificity; Swine; Vas Deferens | 1998 |
Relative importance of medullary brain nuclei for the sympatho-inhibitory actions of rilmenidine in the anaesthetized rabbit.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Baroreflex; Hypotension; Imidazoline Receptors; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Solitary Nucleus; Sympathetic Nervous System | 1998 |
[3H]Rilmenidine-labelled imidazoline-receptor binding sites co-localize with [3H]2-(benzofuranyl)-2-imidazoline-labelled imidazoline-receptor binding sites and monoamine oxidase-B in rabbit, but not rat, kidney.
Topics: Adrenergic alpha-Agonists; Animals; Autoradiography; Benzofurans; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isoenzymes; Kidney; Male; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Rabbits; Rats; Rats, Inbred WKY; Receptors, Drug; Rilmenidine; Species Specificity; Thiazoles | 1998 |
Pharmacology and subcellular distribution of [3H]rilmenidine binding sites in rat brain.
Topics: Adrenergic alpha-Agonists; Animals; Binding Sites; Brain; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Membranes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Radioligand Assay; Rats; Rats, Inbred WKY; Receptors, Drug; Rilmenidine; Subcellular Fractions; Thiazoles | 1998 |
Chronopharmacological dependence of antihypertensive effects of the imidazoline-like drugs in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Clonidine; Dose-Response Relationship, Drug; Heart Rate; Hypertension; Imidazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine | 1998 |
Effect of rilmenidine on the cadiovascular responses to stress in the conscious rabbit.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Female; Heart Rate; Hemodynamics; Kidney; Male; Noise; Oxazoles; Rabbits; Rilmenidine; Stress, Psychological; Sympathetic Nervous System | 1998 |
Interaction of the dopamine D2 receptor agonist quinpirole with sympathetic vasomotor tone and the central action of rilmenidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Dopamine Agonists; Dose-Response Relationship, Drug; Female; Heart Rate; Kidney; Male; Muscle Tonus; Muscle, Smooth, Vascular; Oxazoles; Quinpirole; Rabbits; Receptors, Dopamine D2; Rilmenidine; Sympathetic Nervous System | 1998 |
Comparison of the baroreceptor-heart rate reflex effects of moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Algorithms; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Clonidine; Female; Heart Rate; Imidazoles; Injections, Intraventricular; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Vagus Nerve | 1998 |
Influence of sino-aortic barodenervation on the cardiovascular effects of imidazoline-like drugs.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Circadian Rhythm; Clonidine; Denervation; Heart Rate; Imidazoles; Injections, Intravenous; Male; Motor Activity; Oxazoles; Pressoreceptors; Rats; Rats, Wistar; Rilmenidine; Sinus of Valsalva; Telemetry | 1998 |
Ethanol counteraction of I1-imidazoline but not alpha-2 adrenergic receptor-mediated reduction in vascular resistance in conscious spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Cardiac Output; Central Nervous System Depressants; Drug Interactions; Ethanol; Heart Rate; Imidazoline Receptors; Male; Nordefrin; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Vascular Resistance; Vasoconstrictor Agents | 1999 |
Cardiovascular effects of rilmenidine, moxonidine and clonidine in conscious wild-type and D79N alpha2A-adrenoceptor transgenic mice.
Topics: Adrenergic alpha-Antagonists; Amino Acid Substitution; Animals; Binding, Competitive; Blood Pressure; Cardiovascular Agents; Cell Line; Clonidine; Consciousness; Dogs; Heart Rate; Humans; Imidazoles; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred Strains; Mice, Transgenic; Mutation; Naphthyridines; Oxazoles; Quinolizines; Radioligand Assay; Receptors, Adrenergic, alpha-2; Recombinant Fusion Proteins; Rilmenidine; Saphenous Vein; Tritium | 1999 |
Analysis of the receptor involved in the central hypotensive effect of rilmenidine and moxonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Methyldopa; Norepinephrine; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1999 |
Inhibition of water permeability in the rat collecting duct: effect of imidazoline and alpha-2 compounds.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Arginine Vasopressin; Clonidine; Cyclic AMP; Dose-Response Relationship, Drug; Imidazoles; Kidney Tubules, Collecting; Medetomidine; Oxazoles; Oxymetazoline; Permeability; Rats; Rats, Wistar; Rilmenidine; Water | 1999 |
An unexpected central hypertensive effect of the new imidazoline compound benazoline.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypertension; Imidazoles; Imidazoline Receptors; Male; Nasal Decongestants; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1999 |
Identification of imidazoline-receptor binding sites in cortex and medulla of the bovine adrenal gland. Colocalization with MAO-A and MAO-B.
Topics: Adrenal Cortex; Adrenal Medulla; Adrenergic beta-Agonists; Animals; Autoradiography; Benzofurans; Binding Sites; Cattle; Clonidine; Imidazoles; Imidazoline Receptors; Isoenzymes; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Picolinic Acids; Rats; Receptors, Drug; Rilmenidine; Thiazoles; Tritium | 1999 |
Mechanism of the sympathoinhibition produced by the clonidine-like drugs rilmenidine and moxonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Blood Pressure; Clonidine; Decerebrate State; Heart Rate; Imidazoles; Injections, Spinal; Medulla Oblongata; Microinjections; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1999 |
Central imidazoline- and alpha 2-receptors involved in the cardiovascular actions of centrally acting antihypertensive agents.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Imidazoles; Imidazoline Receptors; Medulla Oblongata; Microinjections; Models, Neurological; Norepinephrine; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Serotonin; Sympathetic Nervous System | 1999 |
alpha 2A-adrenoceptors, not I1-imidazoline receptors, mediate the hypotensive effects of rilmenidine and moxonidine in conscious mice. In vivo and in vitro studies.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cell Line; Dogs; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Hypotension; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxazoles; Quinolizines; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Saphenous Vein; Transfection | 1999 |
Influence of sinoaortic barodenervation on the hypotensive effects of imidazoline-like drugs in stroke-prone spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cerebrovascular Disorders; Circadian Rhythm; Clonidine; Denervation; Heart Rate; Hypotension; Imidazoles; Male; Oxazoles; Pressoreceptors; Rats; Rats, Inbred SHR; Rilmenidine; Sinus of Valsalva; Time Factors | 1999 |
Cardiovascular effects of clonidine-like drugs in pithed rabbits.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular Physiological Phenomena; Clonidine; Electric Stimulation; Heart Rate; Imidazoles; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System; Synaptic Transmission | 1999 |
[New central agents in the treatment of arterial hypertension].
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Adult; Antihypertensive Agents; Atenolol; Calcium Channel Blockers; Clonidine; Diabetes Complications; Humans; Hypertension; Imidazoles; Nifedipine; Oxazoles; Renin-Angiotensin System; Reserpine; Rilmenidine; Risk Factors; Sympathetic Nervous System; Vasodilator Agents | 1999 |
Actions of L-NAME and methylene blue on the hypotensive effects of clonidine and rilmenidine in the anesthetized rat.
Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Cyclic GMP; Drug Interactions; Enzyme Inhibitors; Hypotension; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxazoles; Rats; Rats, Wistar; Rilmenidine | 2000 |
Species-specific pharmacological properties of human alpha(2A)-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adult; Aged; Amino Acid Sequence; Animals; Antihypertensive Agents; Female; Heart Atria; Humans; Imidazoles; Male; Middle Aged; Molecular Sequence Data; Norepinephrine; Oxazoles; Oxymetazoline; Pulmonary Artery; Rabbits; Receptors, Adrenergic, alpha-2; Rilmenidine; Species Specificity; Tritium | 2000 |
Comparison of renal sympathetic baroreflex effects of rilmenidine and alpha-methylnoradrenaline in the ventrolateral medulla of the rabbit.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Dose-Response Relationship, Drug; Female; Idazoxan; Kidney; Male; Medulla Oblongata; Nordefrin; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Rilmenidine; Sympathetic Nervous System; Vasoconstrictor Agents | 2000 |
[Imidazole receptor agonists--a new advance in the treatment of hypertension?].
Topics: Antihypertensive Agents; Humans; Hypertension; Imidazoles; Imidazoline Receptors; Oxazoles; Receptors, Drug; Rilmenidine | 2000 |
Nitric oxide and central antihypertensive drugs: one more difference between catecholamines and imidazolines.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Catecholamines; Clonidine; Heart Rate; Hypotension; Imidazoles; Male; Nitric Oxide; Nitroarginine; Nordefrin; Oxazoles; Rabbits; Rilmenidine | 2001 |
Relative importance of rostral ventrolateral medulla in sympathoinhibitory action of rilmenidine in conscious and anesthetized rabbits.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Female; Kidney; Male; Medulla Oblongata; Microinjections; Oxazoles; Pressoreceptors; Rabbits; Reflex; Rilmenidine; Sympathetic Nervous System | 2001 |
Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Choline; Diglycerides; Enzyme Activation; Imidazoles; Imidazoline Receptors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Oxazoles; PC12 Cells; Phosphorylation; Phosphorylcholine; Rats; Receptors, Drug; Rilmenidine; Signal Transduction; Type C Phospholipases | 2001 |
Synthesis and biological evaluation of pyrrolinic isosteres of rilmenidine. Discovery of cis-/trans-dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H-pyrrol-2-yl)-amine (LNP 509), an I1 imidazoline receptor selective ligand with hypotensive activity.
Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cattle; Cyclopropanes; Frontal Lobe; Imidazoline Receptors; In Vitro Techniques; Kidney Cortex; Ligands; Male; Oxazoles; Pyrroles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Stereoisomerism; Structure-Activity Relationship | 2001 |
Effects of imidazoline antihypertensive drugs on sympathetic tone and noradrenaline release in the prefrontal cortex.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Guanabenz; Heart Rate; Imidazoles; Male; Microdialysis; Norepinephrine; Oxazoles; Prefrontal Cortex; Rats; Rats, Wistar; Rilmenidine; Sympathetic Nervous System | 2001 |
Involvement of imidazoline receptors in the baroreflex effects of rilmenidine in conscious rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Fourth Ventricle; Heart Rate; Imidazoline Receptors; Injections, Intraventricular; Methyldopa; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2001 |
Sympathetic modulation of renal blood flow by rilmenidine and captopril: central vs. peripheral effects.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Captopril; Feedback; Female; Kidney Glomerulus; Male; Oxazoles; Rabbits; Renal Circulation; Rilmenidine; Sympathetic Nervous System | 2002 |
Evidence for synergy between alpha(2)-adrenergic and nonadrenergic mechanisms in central blood pressure regulation.
Topics: Adrenergic Agonists; Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Blood Pressure; Brain Stem; Cardiovascular System; Cyclopropanes; Drug Synergism; Guanosine 5'-O-(3-Thiotriphosphate); Hypotension; Imidazoles; Injections, Intraventricular; Mice; Mice, Transgenic; Microinjections; Nordefrin; Oxazoles; Pyrroles; Rabbits; Receptors, Adrenergic; Receptors, Adrenergic, alpha-2; Rilmenidine; Sympathetic Nervous System | 2002 |
The hypotensive action of rilmenidine is dependent on functional N-methyl-D-aspartate receptor in the rostral ventrolateral medulla of conscious spontaneously hypertensive rats.
Topics: 2-Amino-5-phosphonovalerate; Animals; Antihypertensive Agents; Dose-Response Relationship, Drug; Hemodynamics; Hypertension; Male; Medulla Oblongata; Microinjections; N-Methylaspartate; Oxazoles; Rats; Rats, Inbred SHR; Receptors, N-Methyl-D-Aspartate; Rilmenidine | 2002 |
Protective effects of rilmenidine and AGN 192403 on oxidative cytotoxicity and mitochondrial inhibitor-induced cytotoxicity in astrocytes.
Topics: Animals; Animals, Newborn; Antihypertensive Agents; Antimycin A; Astrocytes; Bridged Bicyclo Compounds; Caspase 9; Caspases; Cell Death; Cytochrome c Group; Dose-Response Relationship, Drug; Free Radicals; Heptanes; Lysosomes; Membrane Potentials; Mitochondria; Models, Chemical; Naphthoquinones; Neuroglia; Oxazoles; Oxidative Stress; Oxygen; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Rilmenidine; Time Factors | 2002 |
Effects of rilmenidine and guanfacine in acute renal denervated rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Denervation; Guanfacine; Heart Rate; Kidney; Male; Natriuresis; Oxazoles; Rats; Rats, Sprague-Dawley; Rilmenidine | 2002 |
Protective effects of centrally acting sympathomodulatory drugs on myocardial ischemia induced by sympathetic overactivity in rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Electrocardiography; Female; Glutamic Acid; Heart Rate; Hemodynamics; Male; Myocardial Ischemia; NG-Nitroarginine Methyl Ester; Oxazoles; Propranolol; Rabbits; Rilmenidine; Sympathetic Nervous System | 2003 |
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2003 |
Alpha2-adrenoceptor ligands inhibit alpha1-adrenoceptor-mediated contraction of isolated rat arteries.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Arteries; Azepines; Brimonidine Tartrate; Clonidine; Idazoxan; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Nitric Oxide; Oxazoles; Prostaglandins; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Yohimbine | 2002 |
Value of rilmenidine therapy and its combination with perindopril on blood pressure and left ventricular hypertrophy in patients with essential hypertension (VERITAS).
Topics: Adrenergic alpha-Agonists; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Drug Therapy, Combination; Echocardiography; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Oxazoles; Perindopril; Rilmenidine | 2003 |
Effect of ethanol on reductions in norepinephrine electrochemical signal in the rostral ventrolateral medulla and hypotension elicited by I1-receptor activation in spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Electrochemistry; Ethanol; Hypotension; Imidazoline Receptors; Male; Medulla Oblongata; Microdialysis; Norepinephrine; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine; Sympatholytics | 2003 |
Rilmenidine produces mydriasis in cats by stimulation of CNS alpha 2-adrenoceptors.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Cats; Central Nervous System; Dose-Response Relationship, Drug; Female; Male; Mydriatics; Oxazoles; Pupil; Receptors, Adrenergic, alpha-2; Rilmenidine | 2003 |
Short-term effects of rilmenidine on left ventricular hypertrophy and systolic and diastolic function in patients with essential hypertension: comparison with an angiotensin converting enzyme inhibitor and a calcium antagonist.
Topics: Aged; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Calcium Channel Blockers; Diastole; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Oxazoles; Rilmenidine; Systole; Ventricular Function, Left | 2003 |
Sympathetic responses to stress and rilmenidine in 2K1C rabbits: evidence of enhanced nonvascular effector mechanism.
Topics: Animals; Blood Pressure; Female; Heart Rate; Hypertension, Renovascular; Kidney; Male; Organ Size; Oxazoles; Rabbits; Rilmenidine; Stress, Physiological; Sympathetic Nervous System | 2004 |
Chronic ethanol administration attenuates imidazoline I1 receptor- or alpha 2-adrenoceptor-mediated reductions in blood pressure and hemodynamic variability in hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Animals; Blood Pressure; Dose-Response Relationship, Drug; Ethanol; Hemodynamics; Hypertension; Imidazoline Receptors; Male; Methyldopa; Motor Activity; Oxazoles; Protein Subunits; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 2004 |
Are centrally acting imidazoline agents appropriate therapy for renovascular hypertension?
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Humans; Hypertension, Renovascular; Kidney; Oxazoles; Rabbits; Renin; Rilmenidine; Sympathetic Nervous System | 2003 |
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Disease Models, Animal; Female; Glucagon; Glucose; Glucose Tolerance Test; Humans; Imidazoles; Imidazoline Receptors; Lipid Metabolism; Male; Metabolic Syndrome; Obesity; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Yohimbine | 2003 |
Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Bridged Bicyclo Compounds; Brimonidine Tartrate; Drug Synergism; Heart; Heptanes; Imidazoles; Imidazoline Receptors; Norepinephrine; Oxazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Sympatholytics; Yohimbine | 2003 |
Alpha(2A)-adrenergic versus imidazoline receptor controversy in rilmenidine's action: alpha(2A)-antagonism in humans versus alpha(2A)-agonism in rabbits.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Antihypertensive Agents; Humans; Imidazoline Receptors; Molecular Sequence Data; Oxazoles; Oxymetazoline; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sequence Alignment | 2003 |
Apparent absence of direct renal effect of imidazoline receptor agonists.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Diuretics; Furosemide; Imidazoles; Imidazoline Receptors; Kidney; Male; Natriuresis; Nephrectomy; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rilmenidine | 2003 |
[Effect of Rilmenidine(Tenaxum) on the activity of the autonomic nervous system in patients with hypertension and asthma].
Topics: Adrenergic alpha-Agonists; Antihypertensive Agents; Asthma; Autonomic Nervous System; Female; Heart Rate; Humans; Hypertension; Oxazoles; Rilmenidine | 2003 |
Chronic treatment with rilmenidine in spontaneously hypertensive rats: differences between two schedules of administration.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Heart Rate; Hypertension; Infusion Pumps; Injections, Intraperitoneal; Male; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine | 2004 |
The effects of the alpha2-adrenergic receptor agonists clonidine and rilmenidine, and antagonists yohimbine and efaroxan, on the spinal cholinergic receptor system in the rat.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzofurans; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Injections, Spinal; Ligands; Male; Microdialysis; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Cholinergic; Rilmenidine; Spinal Cord; Time Factors; Yohimbine | 2004 |
Efficacy and tolerability of long-term rilmenidine treatment in hypertensive diabetic patients. A retrospective analysis of a general practice study.
Topics: Adult; Aged; Antihypertensive Agents; Biomarkers; Blood Pressure; Creatinine; Diabetes Mellitus; Diastole; Drug Therapy, Combination; Family Practice; Female; Humans; Hypertension; Incidence; Male; Middle Aged; Oxazoles; Retrospective Studies; Rilmenidine; Systole; Time; Treatment Outcome; Triglycerides | 2004 |
Differential modulation by estrogen of alpha2-adrenergic and I1-imidazoline receptor-mediated hypotension in female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Animals; Behavior, Animal; Blood Pressure; Estrogens; Female; Heart Rate; Hormone Replacement Therapy; Hypotension; Imidazoline Receptors; Methyldopa; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 2004 |
[Effect of rilmenidine on intraocular pressure in rabbits, interaction with efaroxan and rauwolscine].
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Drug Interactions; Glaucoma; Imidazoles; Intraocular Pressure; Male; Oxazoles; Rabbits; Rilmenidine; Time Factors; Yohimbine | 2004 |
Moxonidine and rilmenidine injected into the medial septal area reduces the salivation induced by pilocarpine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Drug Interactions; Idazoxan; Imidazoles; Male; Muscarinic Agonists; Oxazoles; Pilocarpine; Rats; Rats, Sprague-Dawley; Rilmenidine; Salivation; Septum of Brain; Yohimbine | 2004 |
[Case report: hypertension after stroke].
Topics: Aged; Aged, 80 and over; Amlodipine; Antihypertensive Agents; Basal Ganglia Cerebrovascular Disease; Blood Pressure Monitoring, Ambulatory; Blood Urea Nitrogen; Body Weight; Cerebral Infarction; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Therapy, Combination; Follow-Up Studies; Glycated Hemoglobin; Humans; Hypertension; Internal Capsule; Male; Oxazoles; Prognosis; Ramipril; Rilmenidine; Sympathetic Nervous System | 2004 |
Effects of centrally acting antihypertensive drugs on the microcirculation of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Clonidine; Cyclopropanes; Imidazoline Receptors; Microcirculation; Oxazoles; Pyrroles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine; Splanchnic Circulation; Sympathetic Nervous System; Vasodilation | 2004 |
Rilmenidine prevents blood pressure increase in rats with compromised nitric oxide production.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Blood Pressure; Brain; Endothelium, Vascular; Heart Ventricles; Hypertension; Imidazoline Receptors; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Oxazoles; Rats; Rats, Wistar; Receptors, Drug; Rilmenidine | 2004 |
Mitogen-activated protein kinase phosphorylation in the rostral ventrolateral medulla plays a key role in imidazoline (i1)-receptor-mediated hypotension.
Topics: Animals; Benzofurans; Blood Pressure; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxazoles; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rilmenidine; Signal Transduction | 2005 |
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Blood Pressure; Brain Stem; Cerebrospinal Fluid; Clonidine; Consciousness; Gene Expression; Heart Rate; Hydralazine; Hypotension; Imidazoles; Imidazoline Receptors; Immunohistochemistry; Male; Medulla Oblongata; Neurons; Nordefrin; Oxazoles; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; RNA, Messenger; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Area Postrema; Benzazepines; Benzofurans; Blood Pressure; Clonidine; Consciousness; Heart Rate; Hypotension; Imidazoles; Interleukin-1; Male; Motor Activity; Neurons; Nordefrin; Norepinephrine; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Rilmenidine; Solitary Nucleus | 2005 |
Role of imidazoline receptors in the anti-aversive properties of clonidine during opiate withdrawal in rats.
Topics: Adrenergic alpha-Agonists; Animals; Avoidance Learning; Behavior, Animal; Clonidine; Conditioning, Operant; Dose-Response Relationship, Drug; Drug Interactions; Imidazoline Receptors; Male; Morphine Dependence; Naloxone; Narcotic Antagonists; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rilmenidine; Statistics, Nonparametric; Substance Withdrawal Syndrome | 2005 |
Central actions of agmatine in conscious spontaneously hypertensive rats.
Topics: Agmatine; Animals; Antihypertensive Agents; Blood Pressure; Brain; Cardiovascular System; Clonidine; Consciousness; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Hypertension; Injections, Intraventricular; Male; Movement; Oxazoles; Rats; Rats, Inbred SHR; Rilmenidine | 2005 |
Lipid-lowering actions of imidazoline antihypertensive agents in metabolic syndrome X.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Cell Membrane; Cholesterol; Clonidine; Disease Models, Animal; Female; Guanabenz; Hyperlipidemias; Imidazoles; Imidazoline Receptors; Liver; Male; Metabolic Syndrome; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Drug; Rilmenidine; Triglycerides | 2006 |
Opposite to alpha2-adrenergic agonists, an imidazoline I1 selective compound does not influence reflex bradycardia in rabbits.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Animals; Autonomic Nervous System; Baroreflex; Blood Pressure; Bradycardia; Brain Stem; Cyclopropanes; Dexmedetomidine; Drug Interactions; Drug Synergism; Enzyme Inhibitors; Heart; Heart Rate; Imidazoline Receptors; Male; Nitric Oxide; Nitric Oxide Synthase; Oxazoles; Phenylephrine; Pyrroles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Reticular Formation; Rilmenidine; Solitary Nucleus | 2006 |
Involvement of phosphatidylcholine-selective phospholipase C in activation of mitogen-activated protein kinase pathways in imidazoline receptor antisera-selected protein.
Topics: Animals; Cell Membrane; CHO Cells; Cricetinae; Diglycerides; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Guanosine Triphosphate; Imidazoles; Imidazoline Receptors; Intracellular Signaling Peptides and Proteins; Ligands; MAP Kinase Signaling System; Oxazoles; Rilmenidine; Signal Transduction; Type C Phospholipases | 2006 |
Nischarin as a functional imidazoline (I1) receptor.
Topics: Adrenergic alpha-Agonists; Animals; Antibodies; Imidazoline Receptors; Intracellular Signaling Peptides and Proteins; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; NIH 3T3 Cells; Oligodeoxyribonucleotides, Antisense; Oxazoles; PC12 Cells; Rats; Receptors, Drug; Rilmenidine | 2006 |
Efficacy and tolerability of rilmenidine compared with isradipine in hypertensive patients with features of metabolic syndrome.
Topics: Adult; Aged; Antihypertensive Agents; Blood Glucose; Blood Pressure; Double-Blind Method; Drug Tolerance; Female; Humans; Hypertension; Insulin; Isradipine; Lipids; Male; Metabolic Syndrome; Middle Aged; Oxazoles; Rilmenidine | 2006 |
Effects of rilmenidine on 24-h rhythmicity of blood pressure and spontaneous baroreflex sensitivity in essential hypertensive subjects.
Topics: Adult; Analysis of Variance; Antihypertensive Agents; Baroreflex; Blood Pressure; Circadian Rhythm; Confounding Factors, Epidemiologic; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Oxazoles; Rilmenidine; Severity of Illness Index; Time Factors; Treatment Outcome | 2006 |
Possible role of NMDA receptors in antinociception induced by rilmenidine in mice in the formalin test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Imidazoles; Imidazoline Receptors; Male; Mice; Nervous System; Neurons, Afferent; Nociceptors; Oxazoles; Pain; Pain Measurement; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Rilmenidine; Yohimbine | 2007 |
Contribution of imidazoline receptors and alpha2-adrenoceptors in the rostral ventrolateral medulla to sympathetic baroreflex inhibition by systemic rilmenidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Dose-Response Relationship, Drug; Idazoxan; Imidazoline Receptors; Injections, Intravenous; Kidney; Medulla Oblongata; Neural Inhibition; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System | 2007 |
Direct evidence for imidazoline (I1) receptor modulation of ethanol action on norepinephrine-containing neurons in the rostral ventrolateral medulla in conscious spontaneously hypertensive rats.
Topics: Adrenergic alpha-Agonists; Animals; Blood Pressure; Central Nervous System Depressants; Clonidine; Dose-Response Relationship, Drug; Electrochemistry; Ethanol; Heart Rate; Imidazoline Receptors; Male; Medulla Oblongata; Microinjections; Neurons; Nordefrin; Norepinephrine; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine | 2007 |
Inhibition of nischarin expression attenuates rilmenidine-evoked hypotension and phosphorylated extracellular signal-regulated kinase 1/2 production in the rostral ventrolateral medulla of rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Heart Rate; Hypotension; Intracellular Signaling Peptides and Proteins; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oligodeoxyribonucleotides, Antisense; Oxazoles; Phosphorylation; Rats; Rats, Sprague-Dawley; Rilmenidine | 2008 |
Improvement of cardiac diastolic function by long-term centrally mediated sympathetic inhibition in one-kidney, one-clip hypertensive rabbits.
Topics: Adrenergic beta-Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Cardiomyopathies; Diastole; Disease Models, Animal; Heart Rate; Hypertension, Renovascular; Hypertrophy, Left Ventricular; Ligation; Male; Metoprolol; Myocardial Contraction; Nephrectomy; Oxazoles; Rabbits; Renal Artery; Rilmenidine; Sympathetic Nervous System; Systole; Time Factors; Ultrasonography; Ventricular Function; Ventricular Remodeling | 2008 |
The antiarrhythmic effect of centrally administered rilmenidine involves muscarinic receptors, protein kinase C and mitochondrial signalling pathways.
Topics: Adrenergic alpha-Agonists; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Epinephrine; KATP Channels; Male; Mitochondrial Membrane Transport Proteins; Mitochondrial Permeability Transition Pore; Oxazoles; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Rilmenidine | 2008 |
[Analysis of central mechanisms involved in gastric mucosal integrity].
Topics: Animals; Arachidonic Acids; beta-Endorphin; Clonidine; Endocannabinoids; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Ethanol; Excitatory Amino Acids; Gastric Mucosa; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurotransmitter Agents; Nociceptin; Oligopeptides; Opioid Peptides; Oxazoles; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Opioid; Rilmenidine; Stomach Ulcer | 2008 |
Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha(2)-adrenergic, but not I(1)-imidazoline, receptor activation in female rats.
Topics: Animals; Area Under Curve; Blood Pressure; Ethanol; Female; Heart Rate; Imidazoline Receptors; Methyldopa; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Rilmenidine | 2009 |
Alpha 2A-adrenergic receptor signaling underlies synergistic enhancement of ethanol-induced behavioral impairment by clonidine.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Behavior, Animal; Central Nervous System Depressants; Cerebellum; Clonidine; Drug Synergism; Ethanol; Imidazoline Receptors; Locus Coeruleus; Male; Motor Activity; Oxazoles; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Reflex; Rilmenidine; Rotarod Performance Test | 2009 |
Cardiac and renal baroreflex control during stress in conscious renovascular hypertensive rabbits: effect of rilmenidine.
Topics: Adrenergic alpha-Agonists; Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Female; Heart Rate; Hypertension, Renovascular; Kidney; Male; Oxazoles; Rabbits; Renin; Rilmenidine; Stress, Psychological; Sympathetic Nervous System | 2009 |
The synergistic interaction between rilmenidine and paracetamol in the writhing test in mice.
Topics: Acetaminophen; Animals; Dose-Response Relationship, Drug; Drug Interactions; Drug Synergism; Drug Therapy, Combination; Male; Mice; Oxazoles; Pain; Pain Measurement; Rilmenidine; Rotarod Performance Test | 2009 |
Comparison of agmatine with moxonidine and rilmenidine in morphine dependence in vitro: role of imidazoline I(1) receptors.
Topics: Agmatine; Animals; Antihypertensive Agents; CHO Cells; Cricetinae; Cricetulus; Cyclic AMP; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Morphine Dependence; Oxazoles; Rilmenidine; RNA, Messenger; RNA, Small Interfering; Time Factors; Transfection | 2009 |
Pharmacological analysis of alpha(2)-adrenoceptor subtypes mediating analgesic, anti-inflammatory and gastroprotective actions.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Analgesics; Animals; Anti-Inflammatory Agents; Anti-Ulcer Agents; Clonidine; Disease Models, Animal; Edema; Gastrointestinal Motility; Hyperalgesia; Male; Oxazoles; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Rilmenidine; Stomach Ulcer | 2009 |
Synergistic interaction between rilmenidine and ibuprofen in the writhing test in mice.
Topics: Acetic Acid; Adrenergic alpha-Agonists; Analgesics, Non-Narcotic; Analysis of Variance; Animals; Dose-Response Relationship, Drug; Drug Synergism; Ibuprofen; Male; Mice; Motor Activity; Oxazoles; Pain; Pain Measurement; Rilmenidine; Rotarod Performance Test | 2009 |
Effects of chronic sympatho-inhibition on reflex control of renal blood flow and plasma renin activity in renovascular hypertension.
Topics: Animals; Antihypertensive Agents; Baroreflex; Blood Pressure; Female; Hypertension, Renovascular; Kidney; Male; Oxazoles; Rabbits; Renal Circulation; Renin; Rilmenidine; Sympathetic Nervous System | 2010 |
Microvascular effects of centrally acting antihypertensive drugs in spontaneously hypertensive rats.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Capillaries; Clonidine; Disease Models, Animal; Hypertension; Imidazoles; Male; Microcirculation; Microscopy, Video; Muscle, Skeletal; Oxazoles; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rilmenidine; Skin; Time Factors | 2010 |
Rilmenidine attenuates toxicity of polyglutamine expansions in a mouse model of Huntington's disease.
Topics: Animals; Autophagy; Cells, Cultured; Huntingtin Protein; Huntington Disease; Mice; Mice, Transgenic; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Oxazoles; Peptides; Rilmenidine; Rotarod Performance Test | 2010 |
Development of a fast LC-MS/MS method for quantification of rilmenidine in human serum: elucidation of fragmentation pathways by HRMS.
Topics: Antihypertensive Agents; Chromatography, Liquid; Drug Stability; Humans; Least-Squares Analysis; Oxazoles; Reproducibility of Results; Rilmenidine; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry | 2010 |
Activation of phosphatidylinositol 3-kinase/Akt signaling pathway and endogenous nitric oxide are needed for the antiarrhythmic effect of centrally administered rilmenidine.
Topics: Androstadienes; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Epinephrine; Halothane; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxazoles; Phosphatidylinositol 3-Kinase; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Rilmenidine; Signal Transduction; Sympathomimetics; Wortmannin | 2010 |
Investigation of the effects of the chronic administration of some antihypertensive drugs on enzymatic and non-enzymatic oxidant/antioxidant parameters in rat ovarian tissue.
Topics: Amlodipine; Animals; Antihypertensive Agents; Antioxidants; Clonidine; Female; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Glutathione Transferase; Methyldopa; Ovary; Oxazoles; Oxidants; Ramipril; Rats; Rats, Wistar; Rilmenidine; Superoxide Dismutase | 2011 |
Effects of chronic sympatho-inhibition on renal excretory function in renovascular hypertension.
Topics: Animals; Antihypertensive Agents; Female; Hypertension, Renovascular; Kidney; Male; Oxazoles; Rabbits; Rilmenidine; Sympathetic Nervous System | 2011 |
A novel mechanism for decreasing plasma lipid level from imidazoline I-1 receptor activation in high fat diet-fed mice.
Topics: Animals; Dietary Fats; Feeding Behavior; Gene Expression Regulation; Hep G2 Cells; Humans; Hyperlipidemias; Imidazoline Receptors; Intracellular Signaling Peptides and Proteins; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Oxazoles; Oxidation-Reduction; Receptors, Cytoplasmic and Nuclear; Rilmenidine; Signal Transduction | 2011 |
Rilmenidine improves hepatic steatosis through p38-dependent pathway to higher the expression of farnesoid X receptor.
Topics: Animals; Calcium; Cell Line, Tumor; Diet, High-Fat; Egtazic Acid; Fatty Liver; Humans; Imidazoline Receptors; Lipid Metabolism; Male; MAP Kinase Signaling System; Mice; Mice, Inbred C57BL; Oleic Acid; Oxazoles; Receptors, Cytoplasmic and Nuclear; Rilmenidine | 2012 |
Chronically lowering sympathetic activity protects sympathetic nerves in spleens from aging F344 rats.
Topics: Adrenergic alpha-Agonists; Adrenergic beta-Agonists; Aging; Analysis of Variance; Animals; Body Weight; Catecholamines; Chromatography, High Pressure Liquid; Cyclic AMP; Dose-Response Relationship, Drug; Male; Norepinephrine; Organ Size; Oxazoles; Propanolamines; Protein Binding; Random Allocation; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Rilmenidine; Spleen; Sympathetic Nervous System; Time Factors | 2012 |
Improvement of hyperphagia by activation of cerebral I(1)-imidazoline receptors in streptozotocin-induced diabetic mice.
Topics: Animals; Benzofurans; Cerebrum; Diabetes Mellitus, Type 1; Disease Models, Animal; Eating; Female; Humans; Hyperphagia; Hypothalamus; Imidazoles; Imidazoline Receptors; Male; Mice; Mice, Inbred BALB C; Neuropeptide Y; Oxazoles; Rilmenidine; Streptozocin | 2012 |
Imidazoline-1 receptor ligands as apoptotic agents: pharmacophore modeling and virtual docking study.
Topics: Antineoplastic Agents; Apoptosis; Benzofurans; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Imidazoline Receptors; K562 Cells; Ligands; Models, Molecular; Molecular Docking Simulation; Oxazoles; Quantitative Structure-Activity Relationship; Rilmenidine; Tumor Cells, Cultured | 2013 |
Imidazoline versus alpha₂-adrenoceptors in the control of gastric motility in mice.
Topics: Agmatine; Animals; Electric Stimulation; Female; Gastric Emptying; Harmine; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oxazoles; Piperazines; Receptors, Adrenergic, alpha-2; Rilmenidine; Stomach | 2013 |
Improvement of obesity by activation of I1-imidazoline receptors in high fat diet-fed mice.
Topics: Adipose Tissue, White; Animals; Body Weight; Diet, High-Fat; Energy Intake; Humans; Imidazoline Receptors; Male; Mice; Mice, Inbred C57BL; Obesity; Oxazoles; Rilmenidine | 2013 |
Actions of rilmenidine on neurogenic hypertension in BPH/2J genetically hypertensive mice.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Atropine; Baroreflex; Blood Pressure; Circadian Rhythm; Heart Rate; Hypertension; Infusions, Intraventricular; Infusions, Subcutaneous; Injections, Intraperitoneal; Male; Medulla Oblongata; Mice; Motor Activity; Oxazoles; Restraint, Physical; Rilmenidine; Stress, Physiological; Sympathetic Nervous System; Sympathomimetics | 2014 |
Molecular biology: Remove, reuse, recycle.
Topics: Aging; Alzheimer Disease; Autophagy; Biomedical Research; Caloric Restriction; HIV; Humans; Longevity; Neoplasms; Oxazoles; Parkinson Disease; Phagosomes; Rilmenidine | 2014 |
Rilmenidine suppresses proliferation and promotes apoptosis via the mitochondrial pathway in human leukemic K562 cells.
Topics: Antibiotics, Antineoplastic; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Caspase 3; Cell Cycle; Cell Proliferation; Cyclin B1; Doxorubicin; Humans; Imidazoline Receptors; K562 Cells; Leukemia; Mitochondria; Mitogen-Activated Protein Kinases; Oxazoles; Rilmenidine; RNA, Messenger | 2016 |
Central Sympathetic Modulation Reverses Microvascular Alterations in a Rat Model of High-Fat Diet-Induced Metabolic Syndrome.
Topics: Adrenergic alpha-Agonists; Animals; Clonidine; Diet, High-Fat; Intravital Microscopy; Male; Metabolic Syndrome; Microcirculation; Microvessels; Muscle, Skeletal; Oxazoles; Rats; Rats, Wistar; Rilmenidine; Sodium Chloride, Dietary; Sympathetic Nervous System; Sympatholytics | 2016 |
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.
Topics: Adrenergic alpha-Agonists; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Drug Synergism; Humans; K562 Cells; Ligands; Molecular Structure; Oxazoles; Receptors, Adrenergic, alpha-2; Rilmenidine | 2016 |
The Effects of Rilmenidine and Perindopril on Arousal Blood Pressure during 24 Hour Recordings in SHR.
Topics: Administration, Oral; Animals; Antihypertensive Agents; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Heart Rate; Logistic Models; Male; Oxazoles; Perindopril; Rats; Rats, Inbred SHR; Rilmenidine; Telemetry | 2016 |
MDMA-induced neurotoxicity of serotonin neurons involves autophagy and rilmenidine is protective against its pathobiology.
Topics: Adrenergic alpha-Agonists; Animals; Autophagy; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Male; Mice; Mice, Inbred C57BL; N-Methyl-3,4-methylenedioxyamphetamine; Neuroprotective Agents; Oxazoles; Pregnancy; Rilmenidine; Serotonergic Neurons; Serotonin Agents | 2017 |
An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington's disease.
Topics: Adolescent; Adrenergic alpha-Agonists; Adult; Aged; Brain; Female; Humans; Huntington Disease; Longitudinal Studies; Magnetic Resonance Imaging; Male; Metabolomics; Middle Aged; Neuropsychological Tests; Oxazoles; Retrospective Studies; Rilmenidine; Time Factors; Treatment Outcome; Young Adult | 2017 |