oxazoles has been researched along with piperidines in 126 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 48 (38.10) | 18.7374 |
| 1990's | 28 (22.22) | 18.2507 |
| 2000's | 24 (19.05) | 29.6817 |
| 2010's | 24 (19.05) | 24.3611 |
| 2020's | 2 (1.59) | 2.80 |
| Authors | Studies |
|---|---|
| Goldberg, JS; Rauckman, EJ; Rosen, GM | 1 |
| Kanazawa, M; Kawasaki, K; Ogiwara, T; Sato, K; Tsuyuzaki, K | 1 |
| Hashimoto, S; Shizu, M; Takahashi, S | 1 |
| Kitakaze, T; Ogawa, Y; Tonda, K; Yoshizaki, T | 1 |
| Furukawa, H; Hayashi, Y; Imai, K; Matsuura, M | 1 |
| Foxwell, MH; Johnson, DN; Kilpatrick, BF; Nolan, JC; Proakis, AG; Walsh, DA; Whitman, LL; Yanni, JM | 1 |
| Awouters, F; Janssen, PA; Meert, TF; Megens, AA; Niemegeers, CJ; Schellekens, KH | 1 |
| de Chaffoy de Courcelles, D; Eens, A; Gommeren, W; Janssen, PA; Leysen, JE; Stoof, JC | 1 |
| Awouters, FH; Megens, AA; Niemegeers, CJ | 1 |
| de Haes, P; Janssen, PA; Meert, TF | 1 |
| Burton, P; Gelders, Y; Heylen, S; Mesotten, F; Pietquin, M; Suy, E | 1 |
| de Bruyckere, K; Janssen, PF; Leysen, JE; Schotte, A | 1 |
| Dugovic, C; Janssen, PA; Wauquier, A | 1 |
| Fletcher, PJ; Yu, PH | 1 |
| Hillman, CC; Ornstein, PL; Salhoff, CR; Schoepp, DD | 1 |
| Da Prada, M; Keller, HH; Kettler, R | 1 |
| Byberg, JR; Curtis, DR; Falch, E; Gynther, BD; Hjeds, H; Krogsgaard-Larsen, P; Labouta, IM | 1 |
| Allen, RC; Dunn, RW; Ellis, DB; Gardner, BA; Glamkowski, EJ; Huger, FP; Jones, MC; Schmid, BL; Stache, U; Strupczewski, JT | 1 |
| Masaki, M; Shinozaki, H | 1 |
| Shinozaki, H | 1 |
| Engisch, KL; Wenk, GL | 1 |
| Dostert, P; Strolin Benedetti, M | 1 |
| Finberg, JP; Youdim, MB | 1 |
| Schünemann, J; Wanner, KT | 1 |
| Bhuyan, M; Das, NG; Das, SC; Malhotra, PR | 1 |
| Waldmeier, PC | 1 |
| Boulanger, M; Duhault, J; Le Douarec, JC; Mayeroff, C; Régnier, G | 1 |
| Hsia, JC; MacLennan, DH; Wong, PT | 1 |
| Brooks, UJ; Griffith, OH; Jost, P | 1 |
| Galla, HJ; Overath, P; Sackmann, E; Träuble, H | 1 |
| Chignell, CF | 1 |
| Glasky, AJ; Simon, LN | 1 |
| Berstein, BM; Latimer, CN | 1 |
| Akinlaja, A; Opitz, K | 1 |
| Patil, PN; Yamauchi, D | 1 |
| Magyar, K; Meszaros, Z; Satory, E | 1 |
| Beiler, JM; Holmes, P; Megel, H; Shemano, I; Zalipsky, J | 1 |
| Stepanek, J | 1 |
| Stepanek, J; Zolliker, VR | 1 |
| Chin, CG; Micetich, RG; Raap, R | 1 |
| Cho, AK; Curry, SH; Jacobsen, S | 1 |
| Keup, U; Schneider, F; Seeber, S | 1 |
| Ichikawa, M; Saikachi, H | 1 |
| Jensen, MS; Lambert, JD | 1 |
| Karobath, M; Supavilai, P | 1 |
| Bień, I; Domagalina, E | 1 |
| Hirai, E; Imanishi, H; Umeda, T | 1 |
| Mizojiri, K; Nakajima, Y; Okabe, H; Sugeno, K; Watanabe, J; Yamamoto, E | 2 |
| Buchko, GW; Cadet, J; Morin, B; Weinfeld, M | 1 |
| Gimbrett, R; Priest, RG; Roberts, M; Steinert, J | 1 |
| Bollen, M; De Smedt, H; Himpens, B | 1 |
| Bartoszyk, GD; Dahmen, N; Fischer, V; Hiemke, C; Hödl, P; Reuss, S; Rujescu, D | 1 |
| Maj, J; Mazela, H; Rogóz, Z; Skuza, G | 1 |
| Gallard, JF; Guittet, E; Le, HT; Mayer, M; Michelot, R | 1 |
| Budzinski, R; Eisele, B; Maier, R; Mark, M; Müller, P | 1 |
| Frieboes, RM; Holsboer, F; Murck, H; Steiger, A; Wiedemann, K | 1 |
| Goadsby, PJ | 2 |
| Goetz, AS; Hamaguchi, N; Jeffs, PW; Lybrand, TP; Stouffer, MJ; True, TA | 1 |
| Tong, WQ; Whitesell, G | 1 |
| Monseu, G; Sternon, J | 1 |
| Diener, HC; Fritsche, G; Kazarawa, Z; Limmroth, V | 1 |
| Antonijevic, I; Frieboes, RM; Hinze-Selch, D; Kraus, T; Murck, H; Pollmächer, T; Steiger, A | 1 |
| Aron, ZD; Fink, BE; Katzenellenbogen, JA; Mortensen, DS; Stauffer, SR | 1 |
| Hopkins, B; McHarg, A; Melrose, H; Napier, C; Stewart, M; Wallis, R | 1 |
| Ibrahim, AM; Nawwar, GA; Swellem, RH | 1 |
| Gotthardt, U; Huber, MT; Krieg, JC; Schreiber, W | 1 |
| Dowson, A | 1 |
| Deleu, D; Hanssens, Y | 2 |
| Andreas, J; Benkert, O; Eissner, D; Gründer, G; Heydari, N; Müller, MJ; Nickel, O; Schlegel, S; Schlösser, R; Wetzel, H | 1 |
| Diener, HC; Limmroth, V | 1 |
| Okuyama, S | 1 |
| Bartlett, MG; Stewart, JT; Vishwanathan, K | 1 |
| Logemann, CD; Rankin, LM | 1 |
| Ferrari, MD; Lamers, FP; Roon, KI; Sándor, PS; Schoenen, J; Schoonman, GG; van Dijk, JG | 1 |
| Benkert, O; Gründer, G; Marx-Dannigkeit, P; Müller, MJ; Müller-Siecheneder, F; Wetzel, H | 1 |
| Halayko, AJ; Kahraman, S; Mitchell, RW; Solway, J; Wylam, ME | 1 |
| Hitzel, L; Keown, LE; Ladduwahetty, T; Lewis, RT; MacLeod, AM; Merchant, KJ; Stevenson, GI; Verrier, H | 1 |
| Bartleson, JD | 1 |
| Boggs, CM; Bush, K; Foleno, BD; Goldschmidt, RM; Hlasta, DJ; Weidner-Wells, MA; Wira, E | 1 |
| Cha, JH; Chang, MH; Cho, YS; Kim, HY; Koh, HY; Lee, JS; Pae, AN | 1 |
| Mukai, C; Nomura, I | 1 |
| Cress, WD; Freeman, SN; Ma, Y | 1 |
| Ashton, WT; Dong, H; Doss, GA; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Sisco, RM; Thornberry, NA; Weber, AE; Wu, JK | 1 |
| Blagden, S; de Bono, J | 1 |
| Boon, A; Bridges, D; Deadwyler, SA; Grigorenko, E; Hampson, RE; McCloud, S; Zhuang, SY | 1 |
| Clements, JM; Vanhoose, AM; Winder, DG | 1 |
| Lebovitz, H | 1 |
| Goldstein, S; Hideg, K; Merenyi, G; Samuni, A | 1 |
| Amat, M; Bosch, J; Escolano, C; Lozano, O; Molins, E | 1 |
| Bottle, SE; Coote, ML; Hodgson, JL; Namazian, M | 1 |
| Morgan, IR; Pyne, SG; Skelton, BW; Yazici, A | 1 |
| Bouillot, A; Boullay, AB; Coste, H; Dodic, N; Donche, F; Fouchet, MH; Issandou, M; Junot, C; Magny, SD; Martin, C; Potvain, F; Walker, M | 1 |
| Hashimoto, K; Ishima, T; Iyo, M; Nishimura, T | 1 |
| Chapman, V; Kendall, DA; Sagar, DR | 1 |
| Feng, B; Nelson, FR; Schmidt, K; Troutman, MD; Zelesky, V; Zhou, L | 1 |
| Chen, R; Chubb, S; Fox, JA; Gandhi, V; Hawtin, RE; Keating, MJ; Plunkett, W; Wierda, WG | 1 |
| Bantscheff, M; Drewes, G; Eberhard, D; Frenzel, L; Ghidelli, S; Kruse, U; Maier, SK; Pallasch, CP; Wendtner, CM; Werner, T | 1 |
| Bi, SF; Ge, HM; Li, F; Song, YC; Tan, RX | 1 |
| Alen, F; Gómez, R; Orio, L; Pavón, FJ; Reyes-Cabello, C; Rivera, P; Rodríguez de Fonseca, F; Serrano, A | 1 |
| Kumar, A; Kumar, P; Qiao, Z; Song, ZH | 1 |
| Avagliano, C; Calignano, A; Citraro, R; Cosco, D; D'Agostino, G; De Sarro, G; Di Marzo, V; Gatta, L; Guida, F; Maione, S; Petrosino, S; Russo, E; Russo, R; Scicchitano, F; van Luijtelaar, G; van Rijn, CM | 1 |
| Gujjar, R; Kottani, R; Mahadevan, A; Vann, R; Walentiny, D; Wiley, J | 1 |
| Haas, D; Knochel, P; Mosrin, M | 1 |
| Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M | 1 |
| Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B | 1 |
| Comesse, S; Daïch, A; Lawson, AM; Le Goff, R; Martel, A; Sanselme, M | 1 |
| Futamura, T; Hashimoto, K; Ishima, T; Kikuchi, T; Ohgi, Y; Yoshimi, N | 1 |
| Bresser, T; Haas, D; Hofmayer, MS; Knochel, P | 1 |
| Ceckova, M; Cihalova, D; Staud, F | 1 |
| Bernard, A; Cabiddu, MG; Lacroix, C; Leyssen, P; Neyts, J; Pompei, R | 1 |
| Angius, F; Coluccia, A; Laconi, S; Lacroix, C; Leyssen, P; Neyts, J; Pompei, R; Silvestri, R | 1 |
| Chen, B; Huang, L; Song, J; Yin, L; Zhang, W; Zhang, X | 1 |
| Giordano, A; Morales, F | 1 |
| Kamishikiryo, J; Morita, T; Nakamura, T | 1 |
| Day, CW; Evans, WJ; Nicolaou, KC; Smee, DF; Tarbet, EB | 1 |
| Agarwal, PK; Cao, B; He, Y; Kiran, IN; Lan, Y; Nicolaou, KC; Xu, B; Xu, H; Yu, R; Zhou, X; Zhu, L; Zou, C | 1 |
| Bertron, JL; Blakely, RD; Blobaum, AL; Dickerson, JW; Ennis, EA; Lindsley, CW; Locuson, CW; Rook, JM; Tarr, CJ; Wright, J | 1 |
| Brodney, MA; Davoren, JE; Edgerton, JR; Fortin, JP; Garnsey, M; Grimwood, S; Harris, AR; Jenkinson, S; Kenakin, T; Lazzaro, JT; Lee, CW; Lotarski, SM; Nottebaum, L; O'Neil, SV; Pettersen, B; Popiolek, M; Ramsey, S; Steyn, SJ; Thorn, CA; Webb, D; Zhang, L | 1 |
| Aubé, J; Ferrer, M; Frankowski, KJ; He, S; Hu, X; Hu, Z; Li, K; Liang, TJ; Lin, B; Marugan, JJ; Schoenen, FJ; Southall, N; Wang, AQ; Xiao, J; Xu, X; Zheng, W | 1 |
| Jeong, JH; Jo, HR; Kang, MA; Kim, MH; Kim, W; Shin, YJ | 1 |
| Mazhukin, DG; Zaytseva, EV | 1 |
| Brussee, JM; Dingemanse, J; Fonseca, M; Huynh, C; Meyer Zu Schwabedissen, HE; Pouzol, L; Sidharta, PN | 1 |
12 review(s) available for oxazoles and piperidines
| Article | Year |
|---|---|
Pharmacology of the glutamate receptor.
Topics: 2-Amino-5-phosphonovalerate; Amino Acids; Animals; Anticonvulsants; Antidepressive Agents; Azepines; Glutamates; Glutamic Acid; Membrane Potentials; Nervous System Diseases; Neurons; Oxazoles; Oxazolidinones; Piperidines; Receptors, Glutamate; Receptors, Neurotransmitter; Synapses | 1988 |
Overview of the present state of MAO inhibitors.
Topics: Animals; Benzamides; Humans; Hydrazines; Isoquinolines; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Parkinson Disease; Phenethylamines; Piperidines; Selegiline; Structure-Activity Relationship | 1987 |
Profiles of 5-HT 1B/1D agonists in acute migraine with special reference to second generation agents.
Topics: Acute Disease; Animals; Clinical Trials as Topic; Coronary Circulation; Coronary Vasospasm; Drug Design; Drug Interactions; Humans; Inactivation, Metabolic; Indoles; Meninges; Migraine Disorders; Molecular Structure; Nociceptors; Oxazoles; Oxazolidinones; Piperidines; Propranolol; Pyrrolidines; Randomized Controlled Trials as Topic; Rats; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Recurrence; Serotonin Receptor Agonists; Structure-Activity Relationship; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines; Vasoconstrictor Agents | 1999 |
Acute management of migraine: triptans and beyond.
Topics: Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Sumatriptan; Tryptamines | 1999 |
[Atypical antipsychotic profiles of sigma receptor ligands].
Topics: Animals; Anisoles; Antipsychotic Agents; Clinical Trials as Topic; Dopamine; Dopamine D2 Receptor Antagonists; Drug Evaluation, Preclinical; Humans; Ligands; Oxazoles; Piperazines; Piperidines; Propylamines; Pyrrolidines; Receptors, N-Methyl-D-Aspartate; Receptors, Phencyclidine; Receptors, sigma; Tartrates | 1999 |
The scientific basis of medication choice in symptomatic migraine treatment.
Topics: Acute Disease; Choice Behavior; Dose-Response Relationship, Drug; Humans; Indoles; Migraine Disorders; Models, Biological; Oxazoles; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Severity of Illness Index; Sumatriptan; Triazoles; Tryptamines | 1999 |
Newer intranasal migraine medications.
Topics: Administration, Intranasal; Administration, Oral; Analgesics, Non-Narcotic; Clinical Trials as Topic; Dihydroergotamine; Half-Life; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Recurrence; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines | 2000 |
Current and emerging second-generation triptans in acute migraine therapy: a comparative review.
Topics: Acute Disease; Carbazoles; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Pyrrolidines; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Triazoles; Tryptamines | 2000 |
Drugging cell cycle kinases in cancer therapy.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Binding Sites; Cyclin-Dependent Kinases; Flavonoids; Humans; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Roscovitine; Staurosporine; Sulfonamides; Thiazoles | 2005 |
Diabetes: assessing the pipeline.
Topics: Adamantane; Alkanesulfonates; Amyloid; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Exenatide; Glycine; Humans; Hypoglycemic Agents; Indoles; Islet Amyloid Polypeptide; Maleimides; Nitriles; Oxazoles; Peptides; Phenylpropionates; Piperidines; PPAR alpha; PPAR gamma; Protein Kinase C; Pyrazoles; Pyrrolidines; Receptor, Cannabinoid, CB1; Receptors, Glucagon; Rimonabant; Venoms; Vildagliptin | 2006 |
Overview of CDK9 as a target in cancer research.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Cell Cycle; Cyclic N-Oxides; Cyclin-Dependent Kinase 9; Flavonoids; Humans; Indolizines; Molecular Targeted Therapy; Neoplasms; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; Pyrazoles; Pyridinium Compounds; Roscovitine; Thiazoles; Urea | 2016 |
Spirocyclic Nitroxides as Versatile Tools in Modern Natural Sciences: From Synthesis to Applications. Part I. Old and New Synthetic Approaches to Spirocyclic Nitroxyl Radicals.
Topics: Imidazoles; Imidazolidines; Morpholines; Natural Science Disciplines; Nitrogen Oxides; Oxazoles; Piperidines; Pyrrolidines; Reducing Agents | 2021 |
6 trial(s) available for oxazoles and piperidines
| Article | Year |
|---|---|
[Clinical trial of a new non-steroidal anti-inflammatory analgesic, 31252-S, for postoperative pain following tooth extraction and minor ambulatory surgery].
Topics: Adolescent; Adult; Aged; Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Epirizole; Female; Humans; Isoxazoles; Male; Middle Aged; Minor Surgical Procedures; Mouth; Oxazoles; Pain, Postoperative; Periodontal Cyst; Piperidines; Placebos; Tooth Extraction | 1979 |
Open clinical trial on the sigma ligand panamesine in patients with schizophrenia.
Topics: Acute Disease; Adolescent; Adult; Antipsychotic Agents; Brief Psychiatric Rating Scale; Female; Humans; Male; Oxazoles; Piperidines; Prolactin; Receptors, sigma; Schizophrenia; Sleep | 1997 |
Characterization of the sigma ligand panamesine, a potential antipsychotic, by immune response in patients with schizophrenia and by sleep-EEG changes in normal controls.
Topics: Adjuvants, Immunologic; Adolescent; Adult; Antipsychotic Agents; Blood Cell Count; Double-Blind Method; Electroencephalography; Female; Humans; Locus Coeruleus; Male; Oxazoles; Piperidines; Receptors, sigma; Schizophrenia; Sleep; Tumor Necrosis Factor-alpha | 1999 |
Efficacy and safety of the sigma receptor ligand EMD 57445 (panamesine) in patients with schizophrenia: an open clinical trial.
Topics: Adult; Antipsychotic Agents; Female; Humans; Ligands; Male; Middle Aged; Oxazoles; Piperidines; Psychiatric Status Rating Scales; Receptors, sigma; Schizophrenia; Schizophrenic Psychology | 1999 |
Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial.
Topics: Acute Disease; Adult; Aged; Antipsychotic Agents; Basal Ganglia Diseases; Biotransformation; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Oxazoles; Piperidines; Psychiatric Status Rating Scales; Receptors, sigma; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 1999 |
Target engagement of the first-in-class CXCR7 antagonist ACT-1004-1239 following multiple-dose administration in mice and humans.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Double-Blind Method; Female; Healthy Volunteers; Humans; Long QT Syndrome; Male; Mice; Mice, Inbred DBA; Oxazoles; Piperidines; Receptors, CXCR; Sex Characteristics | 2021 |
108 other study(ies) available for oxazoles and piperidines
| Article | Year |
|---|---|
Bioreduction of nitroxides by Staphylococcus aureus.
Topics: Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Kinetics; Oxazoles; Penicillins; Piperidines; Spin Labels; Staphylococcus aureus | 1977 |
The in vitro metabolism of 3-(1-hydroxy-2-piperidinoethyl)-5-phenyl-isoxazole citrate (31252-S) with rabbit liver homogenate.
Topics: Animals; In Vitro Techniques; Isoxazoles; Kinetics; Liver; Male; Mice; Oxazoles; Piperidines; Rabbits | 1976 |
Drug-induced adrenaline release and blood glucose in rats: 3-phenyl-5(2-piperidinoethyl)-isoxazole citrate.
Topics: Adrenal Glands; Adrenalectomy; Aminopyrine; Animals; Bradykinin; Epinephrine; Histamine; Hypophysectomy; Male; Oxazoles; Phenylbutazone; Piperidines; Rats; Splanchnic Nerves | 1975 |
[Oxidant-drug induced hemolytic anemia in dogs].
Topics: Aminopyrine; Anemia, Hemolytic; Animals; Bilirubin; Blood Cell Count; Blood Proteins; Dogs; Female; Glucosephosphate Dehydrogenase; Glutathione; Isoxazoles; Liver; Male; Methemoglobinemia; Osmotic Fragility; Oxazoles; Phenacetin; Phenylhydrazines; Piperidines; Spleen | 1975 |
AHR-14310C: a potent, long-acting, nonsedating H1-antihistamine that prevents antigen-induced mucus formation in sensitive rats.
Topics: Acetylcholine; Animals; Cats; Dogs; Drug Hypersensitivity; Female; Guinea Pigs; Histamine Antagonists; Histamine H1 Antagonists; Male; Muscle, Smooth; Oxazoles; Oxazolidinones; Piperidines; Rats; Rats, Inbred Strains; Skin Tests; Sleep | 1990 |
Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Conditioning, Psychological; Dogs; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Isoxazoles; Male; Motor Activity; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Risperidone; Serotonin Antagonists | 1988 |
Biochemical profile of risperidone, a new antipsychotic.
Topics: Animals; Antipsychotic Agents; Blood Platelets; Cerebral Cortex; Dopamine; Ergolines; Female; Haloperidol; Isoxazoles; Models, Molecular; Norepinephrine; Oxazoles; Phosphatidic Acids; Piperidines; Quinpirole; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Ritanserin; X-Ray Diffraction | 1988 |
Differential effects of the new antipsychotic risperidone on large and small motor movements in rats: a comparison with haloperidol.
Topics: Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Haloperidol; Isoxazoles; Male; Motor Activity; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Risperidone | 1988 |
Risperidone (R 64 766), a potent and complete LSD antagonist in drug discrimination by rats.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Stimulus; Isoxazoles; Lysergic Acid Diethylamide; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Risperidone | 1989 |
Therapeutic effect and safety of increasing doses of risperidone (R 64766) in psychotic patients.
Topics: Adult; Aged; Antipsychotic Agents; Blood Pressure; Electrocardiography; Female; Hormones; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Piperidines; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone | 1989 |
Receptor occupancy by ritanserin and risperidone measured using ex vivo autoradiography.
Topics: Animals; Brain; Dopamine Antagonists; Isoxazoles; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Ritanserin; Serotonin Antagonists | 1989 |
Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.
Topics: Animals; Antipsychotic Agents; Isoxazoles; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Sleep; Wakefulness | 1989 |
Enhancement of 5-HT-induced anorexia: a test of the reversibility of monoamine oxidase inhibitors.
Topics: Animals; Benzamides; Clorgyline; Drug Synergism; Feeding Behavior; Male; Moclobemide; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1989 |
CGS-19755 and MK-801 selectively prevent rat striatal cholinergic and gabaergic neuronal degeneration induced by N-methyl-D-aspartate and ibotenate in vivo.
Topics: Animals; Aspartic Acid; Choline O-Acetyltransferase; Cholinergic Fibers; Corpus Striatum; Dibenzocycloheptenes; Dizocilpine Maleate; gamma-Aminobutyric Acid; Ibotenic Acid; Male; N-Methylaspartate; Nerve Degeneration; Oxazoles; Pipecolic Acids; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1989 |
[Comparison of the new MAO-A inhibitors moclobemide, brofaromine and toloxatone with tranylcypromine in an animal experiment: significance for clinical practice].
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Antidepressive Agents; Benzamides; Blood Pressure; Heart Rate; Moclobemide; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Piperidines; Rats; Serotonin; Structure-Activity Relationship; Tranylcypromine | 1989 |
Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.
Topics: Animals; Bicuculline; Brain Chemistry; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Isoxazoles; Oxazoles; Piperidines; Pyrrolidines; Rats; Receptors, GABA-A; Synaptic Membranes | 1987 |
Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles.
Topics: Animals; Antipsychotic Agents; Corpus Striatum; In Vitro Techniques; Isoxazoles; Male; Mice; Motor Activity; Oxazoles; Piperidines; Spiperone; Structure-Activity Relationship | 1985 |
A new class of potent centrally acting muscle relaxants: pharmacology of oxazolidinones in rat decerebrate rigidity.
Topics: Animals; Azepines; Decerebrate State; Excitatory Amino Acid Antagonists; Glutamic Acid; Male; Motor Endplate; Muscle Relaxants, Central; Muscle Rigidity; Neurons; Oxazoles; Oxazolidinones; Piperidines; Rats; Rats, Inbred Strains; Reflex; Tremor | 1986 |
[3H]ketanserin (serotonin type 2) binding increases in rat cortex following basal forebrain lesions with ibotenic acid.
Topics: Animals; Cerebral Cortex; Choline O-Acetyltransferase; Diencephalon; Frontal Lobe; Hippocampus; Ibotenic Acid; Ketanserin; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Serotonin; Telencephalon | 1986 |
Potentiation of tyramine pressor responses in conscious rats by reversible inhibitors of monoamine oxidase.
Topics: Animals; Benzamides; Blood Pressure; Clorgyline; Drug Synergism; Male; Moclobemide; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Phenethylamines; Piperidines; Rats; Rats, Inbred Strains; Tyramine | 1988 |
[Synthesis of optically active oxazolo[3,2-a]piperidines from enamides].
Topics: Animals; Central Nervous System; Chromatography, High Pressure Liquid; Mice; Oxazoles; Piperidines | 1987 |
Field trials on the relative efficacy of five repellents against Simulium himalayense (Diptera:Simuliidae).
Topics: Animals; DEET; Drug Evaluation; Insect Repellents; Oxazoles; Phthalic Acids; Piperidines; Simuliidae | 1985 |
On the reversibility of reversible MAO inhibitors.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Benzamides; Brain; Clorgyline; Dopamine; Female; Homovanillic Acid; Kinetics; Liver; Moclobemide; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Phenethylamines; Piperidines; Rats; Rats, Inbred Strains; Serotonin | 1985 |
[Studies on the antiallergic and corticosecretory effects of 8-phenethyl-1-oxa-3,8-diaza-spiro(4,5)decan-2-one (fenspiride, JP 428)].
Topics: Anaphylaxis; Animals; Asthma; Dose-Response Relationship, Drug; Glucocorticoids; Guinea Pigs; Histamine; Histamine H1 Antagonists; Hydrocortisone; Male; Mice; Oxazoles; Piperidines; Rats; Serum Albumin, Bovine; Spiro Compounds | 1972 |
Salt-dependent conformational changes in the cell membrane of Halobacterium salinarium.
Topics: Cell Membrane; Chemical Phenomena; Chemistry; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Halobacterium; Osmolar Concentration; Oxazoles; Piperidines; Sodium Chloride; Stearic Acids | 1971 |
Fluidity of phospholipid bilayers and membranes after exposure to osmium tetroxide and gluteraldehyde.
Topics: Aldehydes; Animals; Cell Membrane; Cyclic N-Oxides; Egg Yolk; Electron Spin Resonance Spectroscopy; Evaluation Studies as Topic; Female; Glutaral; Maleimides; Membranes, Artificial; Methods; Nephropidae; Osmium; Oxazoles; Peripheral Nerves; Phosphatidylcholines; Phospholipids; Piperidines; Stearic Acids | 1973 |
Lateral diffusion, protein mobility, and phase transitions in Escherichia coli membranes. A spin label study.
Topics: Bacterial Proteins; Cardanolides; Cell Membrane; Cyclic N-Oxides; Diffusion; Electron Spin Resonance Spectroscopy; Escherichia coli; Fatty Acids; Lipid Metabolism; Mathematics; Membranes, Artificial; Models, Chemical; Oxazoles; Phosphatidylcholines; Piperidines; Solubility; Spectrometry, Fluorescence; Stereoisomerism; Structure-Activity Relationship; Temperature | 1973 |
New applications of electron spin resonance to problems in biochemistry and pharmacology.
Topics: Animals; Binding Sites; Carbonic Anhydrases; Cell Membrane; Chlorpromazine; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Erythrocytes; Free Radicals; Humans; Immune Sera; Methods; Molecular Conformation; Morphine; Oxazoles; Piperidines; Protein Binding; Protein Conformation; Rabbits; Spin Labels; Sulfonamides; Viscosity | 1973 |
Magnesium pemoline: enhancement of brain RNA polymerases.
Topics: Animals; Anticonvulsants; Brain; Imipramine; In Vitro Techniques; Magnesium; Methamphetamine; Methylphenidate; Nucleotidyltransferases; Oxazoles; Pargyline; Pemoline; Piperidines; Rats; RNA; Trimethadione | 1966 |
Behavioral facilitation: the interaction of imipramine and desipra- mine with amphetamine, alpha-pipradrol, methylphenidate, and thozalinone.
Topics: Amphetamine; Animals; Antidepressive Agents; Avoidance Learning; Behavior, Animal; Desipramine; Drug Synergism; Imipramine; Male; Methylphenidate; Oxazoles; Piperidines; Rats; Stimulation, Chemical | 1968 |
[On the influencing of food intake by psychotropic drugs].
Topics: Amitriptyline; Animals; Behavior, Animal; Body Weight; Central Nervous System; Central Nervous System Stimulants; Chlordiazepoxide; Chlorpromazine; Chlorprothixene; Eating; Feeding and Eating Disorders; Female; Haloperidol; Humans; Imipramine; Nutritional Physiological Phenomena; Oxazepam; Oxazoles; Pemoline; Phenobarbital; Piperidines; Promethazine; Psychopharmacology; Rats; Reserpine; Thiazines | 1966 |
Influence of the optical isomers of some centrally acting drugs on norepinephrine responses.
Topics: Amphetamine; Animals; Drug Synergism; In Vitro Techniques; Male; Morpholines; Norepinephrine; Oxazoles; Piperidines; Rats; Stereoisomerism; Vas Deferens | 1970 |
The monoamine oxidase inhibitory effect of new homopyrimidazole derivatives.
Topics: Amines; Animals; Benzyl Compounds; Brain; Carbon Radioisotopes; Depression, Chemical; Male; Mitochondria; Mitochondria, Liver; Monoamine Oxidase Inhibitors; Oxazoles; Oxidation-Reduction; Piperidines; Pyridines; Pyrimidinones; Rats; Serotonin; Time Factors; Tritium; Tyramine | 1974 |
Fenspiride -14 C: its distribution, excretion and metabolism in the rat.
Topics: Administration, Oral; Animals; Bronchodilator Agents; Carbon Isotopes; Chromatography, Thin Layer; Female; Intestinal Absorption; Male; Oxazoles; Piperidines; Rats; Spiro Compounds | 1973 |
[Alteration of the acid-base equilibrium by the anorectic diphemethoxidine in comparison with the effect of amphetamine and aminorex].
Topics: Acid-Base Equilibrium; Amines; Amphetamine; Animals; Appetite Depressants; Blood Gas Analysis; Blood Pressure; Body Temperature; Dogs; Hydrogen-Ion Concentration; Lactates; Oxazoles; Piperidines; Potassium; Pulse; Respiration; Sodium; Time Factors | 1972 |
[Circulatory effects of the anorectic Diphemethoxidine compared with the effects of Amphetamine and Aminorex].
Topics: Animals; Appetite Depressants; Blood Circulation; Blood Pressure; Depression, Chemical; Dextroamphetamine; Dogs; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Lactose; Oxazoles; Perfusion; Piperidines; Pulmonary Artery; Pulmonary Circulation; Stimulation, Chemical | 1971 |
Studies in isoxazole chemistry. 5. N-alkylation and N-acylation of 5-amino-3-(5-nitro-2-furyl)isoxazoles.
Topics: Acetamides; Allyl Compounds; Amides; Amines; Animals; Bacteria; Carbamates; Carboxylic Acids; Chlorine; Fluorine; Furans; Morpholines; Nitriles; Nitro Compounds; Oxazoles; Piperidines; Structure-Activity Relationship; Trichomonas | 1971 |
Localization of basic drugs in the submaxillary gland.
Topics: Animals; Biological Transport; Brain Chemistry; Carbon Isotopes; Cats; Duodenum; Hydrogen-Ion Concentration; Imidazoles; Inulin; Liver; Lung; Male; Mathematics; Muscles; Oxazoles; Piperidines; Pyrazoles; Pyridines; Rats; Saliva; Stomach; Submandibular Gland; Time Factors; Vasodilator Agents; Water | 1969 |
[Cytostatically active N-acyloxymethyl compounds].
Topics: Acetates; Animals; Antineoplastic Agents; Benzoates; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cinnamates; Depression, Chemical; DNA, Neoplasm; Esters; Imidazoles; Imides; In Vitro Techniques; Leucine; Mice; Morpholines; Neoplasm Proteins; Oxazoles; Piperidines; Pyrrolidinones; RNA, Neoplasm; Thymidine; Uridine | 1969 |
[Studies on synthesis of coumarin derivatives. XIX. On the preparation of (2-methyloxazolo)coumarin-3-carboxylic acid derivatives].
Topics: Coumarins; Ethylamines; Morpholines; Oxazoles; Piperidines; Pyrrolidines; Sodium Hydroxide | 1966 |
Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. An electrophysiological study on cultured mouse neurones.
Topics: Animals; Benzodiazepines; Carbolines; Cells, Cultured; Convulsants; Electrophysiology; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Mice; Midazolam; Neurons; Oxazoles; Piperidines; Receptors, GABA-A | 1984 |
The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid.
Topics: Animals; Anti-Anxiety Agents; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Oxazoles; Piperidines; Rats; Stimulation, Chemical; Temperature; Tritium | 1980 |
[2-alkylaminomethyl-benzoisoxazolin-3-ones].
Topics: Animals; Antinematodal Agents; Antitrichomonal Agents; Chemical Phenomena; Chemistry; Depression; Drug Evaluation, Preclinical; Humans; Isoxazoles; Mice; Morpholines; Nematoda; Oxazoles; Piperazines; Piperidines; Trichomonas vaginalis | 1981 |
Analytical studies on isoxazoles. II A new fluorimetric determination of 5-phenyl-3-isoxazolecarboxylic acid and its application to the determination of perisoxal in plasma.
Topics: Humans; Isoxazoles; Oxazoles; Piperidines; Spectrometry, Fluorescence | 1980 |
Isolation of perisoxal glucuronides and determination of enantiomeric ratios of d-and l-perisoxal metabolites excreted in rabbit urine.
Topics: Animals; Glucuronates; Isoxazoles; Male; Oxazoles; Piperidines; Rabbits; Stereoisomerism | 1981 |
Determination of perisoxal and its phenolic metabolites in rat, rabbit and human urine.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biotransformation; Female; Humans; Isoxazoles; Oxazoles; Phenols; Piperidines; Rabbits; Rats; Species Specificity | 1980 |
Photooxidation of d(TpG) by riboflavin and methylene blue. Isolation and characterization of thymidylyl-(3',5')-2-amino-5-[(2-deoxy-beta-D- erythro-pentofuranosyl)amino]-4H-imidazol-4-one and its primary decomposition product thymidylyl-(3',5')-2,2-diamin
Topics: Bacteriophage T4; Chemical Phenomena; Chemistry, Physical; Chromatography, High Pressure Liquid; Dinucleoside Phosphates; Hot Temperature; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Magnetic Resonance Spectroscopy; Methoxamine; Methylene Blue; Oxazoles; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphorylation; Photochemistry; Piperidines; Polynucleotide 5'-Hydroxyl-Kinase; Riboflavin; Spectrometry, Mass, Fast Atom Bombardment; Thymidine | 1995 |
Reversible and selective inhibitors of monoamine oxidase A in mental and other disorders.
Topics: Alzheimer Disease; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Benzamides; Humans; Moclobemide; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Panic Disorder; Phobic Disorders; Piperidines | 1995 |
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation.
Topics: Adenosine Triphosphate; Animals; Benzoquinones; Calcium; Cell Line; Cell Nucleus; Colforsin; Cricetinae; Cytosol; Diacylglycerol Kinase; Epidermal Growth Factor; Ethers, Cyclic; Homeostasis; Kinetics; Lactams, Macrocyclic; Leiomyosarcoma; Marine Toxins; Mesocricetus; Models, Biological; Muscle, Smooth; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Quinazolines; Quinazolinones; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Induction of c-fos gene expression by the selective sigma receptor ligand EMD 57445 in rat brain.
Topics: Animals; Antipsychotic Agents; Brain; Dose-Response Relationship, Drug; Female; Hippocampus; In Situ Hybridization; Oxazoles; Piperidines; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1996 |
Neuropharmacological profile of EMD 57445, a sigma receptor ligand with potential antipsychotic activity.
Topics: Animals; Antipsychotic Agents; Locomotion; Male; Mice; Morphine; Oxazoles; Piperidines; Rats; Rats, Wistar | 1996 |
Use of BOP-Cl in the presence of Boc-amino monothioacids for the thioacylation of imino acid residues.
Topics: Amino Acids; Cross-Linking Reagents; Imines; Leucine; Models, Chemical; Organophosphorus Compounds; Oxazoles; Phosphorus; Piperidines; Proline; Sulfhydryl Compounds; Thioamides | 1996 |
Effects of a novel 2,3-oxidosqualene cyclase inhibitor on cholesterol biosynthesis and lipid metabolism in vivo.
Topics: Animals; Cholesterol; Cricetinae; Enzyme Inhibitors; Hydroxymethylglutaryl CoA Reductases; Intramolecular Transferases; Isomerases; Lipid Metabolism; Lipids; Lipoproteins, LDL; Liver; Male; Mesocricetus; Mice; Mice, Inbred Strains; Oxazoles; Piperidines; Rats; Rats, Wistar; Receptors, LDL; RNA, Messenger; Squalene; Tumor Cells, Cultured | 1997 |
A triptan too far?
Topics: Acute Disease; Clinical Trials as Topic; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Sumatriptan; Tryptamines | 1998 |
Alpha 1-adrenergic receptor subtype determinants for 4-piperidyl oxazole antagonists.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Amino Acid Sequence; Animals; Cell Membrane; COS Cells; Ligands; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxazoles; Piperidines; Receptors, Adrenergic, alpha-1; Recombinant Fusion Proteins | 1998 |
In situ salt screening--a useful technique for discovery support and preformulation studies.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists; Algorithms; Chemistry, Pharmaceutical; Hydrogen-Ion Concentration; Kinetics; Oxazoles; Piperidines; Potentiometry; Solubility; X-Ray Diffraction | 1998 |
New "triptans" and other drugs for migraine.
Topics: Adrenergic beta-Antagonists; Amitriptyline; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Calcium Channel Blockers; Dihydroergotamine; Drug Interactions; Ergotamine; Humans; Indoles; Methysergide; Migraine Disorders; Naproxen; Oxazoles; Oxazolidinones; Piperidines; Propranolol; Selective Serotonin Reuptake Inhibitors; Serotonin Receptor Agonists; Sumatriptan; Time Factors; Timolol; Triazoles; Tryptamines; Valproic Acid; Vasoconstrictor Agents | 1998 |
[Zolmitriptan].
Topics: Chemistry, Pharmaceutical; Humans; Indoles; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Sumatriptan; Tryptamines | 1998 |
Headache after frequent use of serotonin agonists zolmitriptan and naratriptan.
Topics: Adult; Female; Headache; Humans; Indoles; Middle Aged; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Tryptamines | 1999 |
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.
Topics: Binding Sites; Estradiol; Estrogen Antagonists; Estrogens; Imidazoles; Isoxazoles; Ligands; Models, Molecular; Oxazoles; Piperidines; Protein Conformation; Pyrazoles; Raloxifene Hydrochloride; Receptors, Estrogen; Thiazoles; X-Ray Diffraction | 1999 |
Characterisation of the 5-HT receptor binding profile of eletriptan and kinetics of [3H]eletriptan binding at human 5-HT1B and 5-HT1D receptors.
Topics: Animals; Binding, Competitive; Cell Line; Cold Temperature; COS Cells; HeLa Cells; Humans; Indoles; Kinetics; Oxazoles; Oxazolidinones; Piperidines; Pyrrolidines; Radioligand Assay; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Sumatriptan; Triazoles; Tritium; Tryptamines | 1999 |
Oxazole, pyrazole and piperidine derivatives having an o-hydroxyaryl moiety with anticipated molluscicidal activity.
Topics: Animals; Biomphalaria; Chemical Phenomena; Chemistry, Physical; Molluscacides; Oxazoles; Piperidines; Pyrazoles | 1994 |
Drug-induced headaches.
Topics: Analgesics, Non-Narcotic; Ergotamine; Headache; Humans; Indoles; Oxazoles; Oxazolidinones; Piperidines; Serotonin Receptor Agonists; Sumatriptan; Tryptamines | 1999 |
Occupancy of striatal D(2)-like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic.
Topics: Adult; Antipsychotic Agents; Benzamides; Blood-Brain Barrier; Corpus Striatum; Female; Humans; Male; Middle Aged; Oxazoles; Piperidines; Pyrimidines; Pyrrolidines; Receptors, Dopamine D2; Receptors, sigma; Schizophrenia; Tomography, Emission-Computed, Single-Photon | 1999 |
Determination of antimigraine compounds rizatriptan, zolmitriptan, naratriptan and sumatriptan in human serum by liquid chromatography/electrospray tandem mass spectrometry.
Topics: Bufotenin; Chromatography, High Pressure Liquid; Humans; Indoles; Mass Spectrometry; Migraine Disorders; Molecular Structure; Oxazoles; Oxazolidinones; Piperidines; Sensitivity and Specificity; Serotonin Receptor Agonists; Sumatriptan; Triazoles; Tryptamines; Vasoconstrictor Agents | 2000 |
Auditory evoked potentials in the assessment of central nervous system effects of antimigraine drugs.
Topics: Adolescent; Adult; Cerebral Cortex; Evoked Potentials, Auditory; Female; Humans; Indoles; Male; Oxazoles; Oxazolidinones; Piperidines; Reproducibility of Results; Sample Size; Serotonin Receptor Agonists; Tryptamines | 1999 |
Selective restoration of calcium coupling to muscarinic M(3) receptors in contractile cultured airway myocytes.
Topics: Acetylcholine; Animals; Atropine; Blood Proteins; Blotting, Western; Bradykinin; Calcium; Calcium Channels; Cells, Cultured; Diamines; Dogs; Dose-Response Relationship, Drug; Fluorescent Dyes; Fura-2; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Muscarinic Antagonists; Muscle, Smooth; Oxazoles; Parasympatholytics; Phenotype; Piperidines; Pirenzepine; Receptor, Muscarinic M3; Receptors, Bradykinin; Receptors, Cytoplasmic and Nuclear; Receptors, Muscarinic; Trachea; Vasodilator Agents | 2000 |
An efficient protocol for the preparation of primary alcohols bearing a beta-chiral center via an oxazolidinone auxiliary mediated resolution, and application to the synthesis of 4,4-disubstituted piperidine substance P antagonists.
Topics: Alcohols; Calorimetry; Diazonium Compounds; Magnetic Resonance Spectroscopy; Oxazoles; Piperidines; Stereoisomerism; Substance P | 2000 |
Triptans to the rescue: effective therapy for migraine headaches in the workplace.
Topics: Absenteeism; Adult; Cost-Benefit Analysis; Efficiency; Female; Humans; Indoles; Injections, Subcutaneous; Male; Migraine Disorders; Oxazoles; Oxazolidinones; Piperidines; Randomized Controlled Trials as Topic; Self Administration; Serotonin Receptor Agonists; Sumatriptan; Treatment Outcome; Triazoles; Tryptamines; Workplace | 2000 |
Novel piperidinyloxy oxazolidinone antimicrobial agents.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance; Escherichia coli; Gram-Negative Bacteria; Gram-Positive Bacteria; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Piperidines; Staphylococcus aureus | 2001 |
Synthesis and in vitro activity of new methylenepiperidinyl and methylenepyrrolidinyl oxazolidinone antibacterial agents.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Area Under Curve; Bacteria; Drug Resistance, Bacterial; Enterococcus; Gram-Positive Bacteria; Indicators and Reagents; Male; Microbial Sensitivity Tests; Oxazoles; Piperidines; Pyrrolidines; Rats; Staphylococcus; Structure-Activity Relationship; Vancomycin | 2003 |
Studies on the total synthesis of streptazolin and its related natural products: first total synthesis of (+/-)-8alpha-hydroxystreptazolone.
Topics: Alkynes; Anti-Infective Agents; Biological Products; Heterocyclic Compounds, 3-Ring; Ketones; Oxazoles; Piperidines; Stereoisomerism | 2004 |
E2F4 deficiency promotes drug-induced apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cell Cycle Proteins; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; E2F4 Transcription Factor; Fibroblasts; Flavonoids; Humans; Lung Neoplasms; Mice; Mice, Knockout; Oxazoles; Piperidines; Protein Kinase Inhibitors; Purines; RNA, Small Interfering; Roscovitine; Thiazoles; Transcription Factors; Tumor Cells, Cultured | 2004 |
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Topics: Dipeptidyl Peptidase 4; Isoxazoles; Oxazoles; Piperidines; Protease Inhibitors; Pyrazoles; Thiazoles | 2005 |
Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores.
Topics: Animals; Benzoxazines; Calcium; Cell Culture Techniques; Cell Death; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclohexanols; Dantrolene; Drug Interactions; Estrenes; Fetus; Hippocampus; Macrocyclic Compounds; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Okadaic Acid; Oxazoles; Piperidines; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Thionucleotides | 2005 |
Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcineurin Inhibitors; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclosporine; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Hippocampus; Isoproterenol; Long-Term Potentiation; Male; Marine Toxins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Oxazoles; Phenols; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Piperidines; Protein Phosphatase 1; Protein Phosphatase 2; Protein Processing, Post-Translational; Receptors, Adrenergic, beta-1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Structure-activity relationship of cyclic nitroxides as SOD mimics and scavengers of nitrogen dioxide and carbonate radicals.
Topics: Antioxidants; Carbonates; Cyclic N-Oxides; Free Radical Scavengers; Free Radicals; Hydrogen-Ion Concentration; Kinetics; Molecular Mimicry; Nitrogen Dioxide; Oxazoles; Oxidation-Reduction; Piperidines; Pulse Radiolysis; Pyrrolidines; Structure-Activity Relationship; Superoxide Dismutase; Superoxides | 2006 |
Enantioselective synthesis of 3,3-disubstituted piperidine derivatives by enolate dialkylation of phenylglycinol-derived oxazolopiperidone lactams.
Topics: Alkylation; Ethanolamines; Glycine; Indole Alkaloids; Lactams; Oxazoles; Piperidines; Piperidones; Stereoisomerism | 2007 |
One-electron oxidation and reduction potentials of nitroxide antioxidants: a theoretical study.
Topics: Antioxidants; Electrodes; Electrons; Models, Chemical; Nitrogen Oxides; Oxazoles; Oxidation-Reduction; Piperidines; Pyrrolidines; Thermodynamics | 2007 |
Diastereoselective Ritter reactions of chiral cyclic N-acyliminium ions: synthesis of pyrido- and pyrrolo[2,3-d]oxazoles and 4-Hydroxy-5-N-acylaminopyrrolidines and 5-hydroxy-6-N-acylaminopiperidines.
Topics: Imines; Molecular Conformation; Nitriles; Oxazoles; Piperidines; Pyrrolidines; Stereoisomerism | 2008 |
Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity.
Topics: Animals; Anticholesteremic Agents; Cataract; Cell Line, Tumor; Dyslipidemias; Enzyme Inhibitors; Eye; Female; Humans; Intramolecular Transferases; Liver; Male; Oxazoles; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley | 2008 |
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors.
Topics: Analysis of Variance; Animals; Anisoles; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Indans; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Microtubule-Associated Proteins; Nerve Growth Factor; Neurites; Oxazoles; PC12 Cells; Physostigmine; Piperidines; Propylamines; Rats; Receptors, sigma; Sigma-1 Receptor | 2008 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; Inflammation; Oxazoles; Pain; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Tyrosine | 2008 |
The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.
Topics: Adrenergic alpha-Antagonists; Algorithms; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Benzamides; Blood Proteins; Brain; Cell Line; Chromatography, High Pressure Liquid; Dogs; Flavonoids; Imatinib Mesylate; Mass Spectrometry; Mice; Mice, Knockout; Oxazoles; Piperazines; Piperidines; Prazosin; Propionates; Protein Binding; Pyrimidines | 2009 |
Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia.
Topics: Adult; Aged; Aged, 80 and over; Apoptosis; Caspases; Cyclin-Dependent Kinases; Female; Flavonoids; Humans; Immunoblotting; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphocytes; Male; Membrane Potential, Mitochondrial; Middle Aged; Myeloid Cell Leukemia Sequence 1 Protein; Oxazoles; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-bcl-2; Purines; RNA Polymerase II; RNA, Neoplasm; Roscovitine; Thiazoles; Transcription, Genetic; X-Linked Inhibitor of Apoptosis Protein | 2009 |
Chemoproteomics-based kinome profiling and target deconvolution of clinical multi-kinase inhibitors in primary chronic lymphocytic leukemia cells.
Topics: Apoptosis; Flavonoids; Humans; Leukemia, Lymphocytic, Chronic, B-Cell; Oxazoles; Piperidines; Positive Transcriptional Elongation Factor B; Protein Kinase Inhibitors; Proteomics; Thiazoles | 2011 |
New acrylamide and oxazolidin derivatives from a termite-associated Streptomyces sp.
Topics: Acrylamides; Animals; Anti-Bacterial Agents; Antineoplastic Agents; Drug Screening Assays, Antitumor; Fermentation; Isoptera; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Piperidines; Pyrroles; Spectrometry, Mass, Electrospray Ionization; Spectrophotometry, Infrared; Spectrophotometry, Ultraviolet; Streptomyces | 2011 |
Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration.
Topics: Animals; Arachidonic Acids; Eating; Endocannabinoids; Energy Intake; Feeding Behavior; Food Deprivation; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Knockout; Nutritional Status; Oxazoles; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Satiation; Tyrosine | 2012 |
Effects of palmitoylethanolamide on aqueous humor outflow.
Topics: Amides; Animals; Aqueous Humor; Blotting, Western; Camphanes; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Activation; Ethanolamines; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organ Culture Techniques; Oxazoles; Palmitic Acids; Phosphorylation; Piperidines; PPAR alpha; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Swine; Trabecular Meshwork; Tyrosine | 2012 |
Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.
Topics: Amides; Animals; Anticonvulsants; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electroencephalography; Endocannabinoids; Epilepsy, Absence; Ethanolamines; Glycerides; Injections, Intraventricular; Lipid Metabolism; Male; Oxazoles; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tyrosine | 2013 |
Novel 3-substituted rimonabant analogues lack Δ(9) -tetrahydrocannabinol-like abuse-related behavioural effects in mice.
Topics: Animals; Behavior, Animal; Cannabinoid Receptor Antagonists; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Male; Mice; Mice, Inbred C57BL; Morphine; Oxazoles; Piperidines; Pyrazoles; Rimonabant; Structure-Activity Relationship | 2013 |
Regioselective functionalization of the oxazole scaffold using TMP-bases of Mg and Zn.
Topics: Lithium; Magnesium; Molecular Structure; Organometallic Compounds; Oxazoles; Piperidines; Stereoisomerism; Zinc | 2013 |
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C.
Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication | 2014 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morpholines; Naphthalenes; Oxazoles; Pentylenetetrazole; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Thiazolidinediones; Tyrosine | 2015 |
Simple access to highly functional bicyclic γ- and δ-lactams: origins of chirality transfer to contiguous tertiary/quaternary stereocenters assessed by DFT.
Topics: Bridged Bicyclo Compounds, Heterocyclic; Hydrogen Bonding; Lactams; Models, Molecular; Molecular Conformation; Oxazoles; Piperidines; Pyrrolidinones; Stereoisomerism | 2015 |
Potentiation of neurite outgrowth by brexpiprazole, a novel serotonin-dopamine activity modulator: a role for serotonin 5-HT1A and 5-HT2A receptors.
Topics: Animals; Aripiprazole; Boron Compounds; Dose-Response Relationship, Drug; Drug Synergism; Fluorobenzenes; HSP90 Heat-Shock Proteins; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Nerve Growth Factor; Neurites; Oxazoles; PC12 Cells; Piperazines; Piperidines; Pyridines; Quinolones; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT2A; Serotonin Agents; Thiophenes | 2015 |
Zincation of 4,4-dimethyloxazoline using TMPZnCl·LiCl. A new preparation of 2-aryloxazolines.
Topics: Catalysis; Organometallic Compounds; Oxazoles; Piperidines; Zinc | 2015 |
Interactions of cyclin-dependent kinase inhibitors AT-7519, flavopiridol and SNS-032 with ABCB1, ABCG2 and ABCC1 transporters and their potential to overcome multidrug resistance in vitro.
Topics: Animals; ATP-Binding Cassette Transporters; Cell Proliferation; Dogs; Drug Interactions; Drug Resistance, Multiple; Flavonoids; Humans; Madin Darby Canine Kidney Cells; Oxazoles; Piperidines; Protein Kinase Inhibitors; Pyrazoles; Thiazoles | 2015 |
Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Enterovirus; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Piperidines; Pyridazines; Structure-Activity Relationship | 2015 |
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses.
Topics: Antiviral Agents; Capsid Proteins; Humans; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Piperidines; Protein Binding; Pyridazines; Rhinovirus | 2015 |
Synthesis and pharmacological evaluation of piperidine (piperazine)-substituted benzoxazole derivatives as multi-target antipsychotics.
Topics: Animals; Antipsychotic Agents; Ether-A-Go-Go Potassium Channels; Humans; Mice; Oxazoles; Patch-Clamp Techniques; Piperazines; Piperidines; Potassium Channel Blockers; Rats; Receptors, Dopamine D2; Schizophrenia; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT2 Receptor Agonists; Structure-Activity Relationship; Swine | 2015 |
Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II.
Topics: Animals; Benzophenanthridines; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Estrenes; Hepatocytes; Lipoprotein Lipase; Macrocyclic Compounds; Male; Oxazoles; Piperidines; Prazosin; Primary Cell Culture; Pyrrolidinones; Quinazolinones; Rats; Sulfonamides; Time Factors; Trifluoperazine | 2016 |
Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds.
Topics: A549 Cells; Antimetabolites; Antiviral Agents; Benzimidazoles; Enterovirus A, Human; Enterovirus D, Human; Guanine; HeLa Cells; Humans; Oxadiazoles; Oxazoles; Oximes; Picornaviridae; Piperazines; Piperidines; Pyridazines; Rhabdomyosarcoma; Rhinovirus; Ribavirin; Sulfonamides | 2016 |
Efficient Synthesis of Dimeric Oxazoles, Piperidines and Tetrahydroisoquinolines from N-Substituted 2-Oxazolones.
Topics: Catalysis; Cyclization; Dimerization; Isoquinolines; Oxazoles; Oxazolone; Piperidines; Stereoisomerism | 2016 |
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Half-Life; Inhibitory Concentration 50; Isoxazoles; Membrane Transport Proteins; Oxazoles; Piperidines; Rats; Structure-Activity Relationship | 2016 |
Design and Synthesis of γ- and δ-Lactam M
Topics: Allosteric Regulation; Amphetamine; Animals; Ataxia; Diarrhea; Dogs; Donepezil; Drug Design; Female; Humans; Indans; Isoindoles; Lactams; Male; Mice, Inbred C57BL; Microsomes, Liver; Oxazoles; Piperidines; Rats, Wistar; Receptor, Muscarinic M1; Scopolamine; Seizures; Structure-Activity Relationship; Sulfonamides; Thiadiazoles; Vomiting | 2017 |
Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.
Topics: Animals; Antiviral Agents; Cell Line, Tumor; Drug Synergism; Hepacivirus; Humans; Liver; Male; Mice; Oxazoles; Piperidines; Stereoisomerism; Structure-Activity Relationship; Tissue Distribution; Virus Internalization; Virus Replication | 2017 |
Anticancer and radiosensitizing effects of the cyclin-dependent kinase inhibitors, AT7519 and SNS‑032, on cervical cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cyclin-Dependent Kinases; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Lung Neoplasms; Mice; Oxazoles; Piperidines; Pyrazoles; Radiation-Sensitizing Agents; Thiazoles; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays | 2018 |