Page last updated: 2024-08-21

oxazoles and oxadiazoles

oxazoles has been researched along with oxadiazoles in 147 studies

Research

Studies (147)

Timeframe	Studies, this research(%)	All Research%
pre-1990	24 (16.33)	18.7374
1990's	22 (14.97)	18.2507
2000's	54 (36.73)	29.6817
2010's	39 (26.53)	24.3611
2020's	8 (5.44)	2.80

Authors

Authors	Studies
Mori, A; Sakai, A; Takeuchi, H; Yokoi, I	1
Cha, JH; Drejer, J; Honoré, T; Nielsen, EO; Young, AB	1
Morrow, C; Murphy, S; Pearce, B	1
Alexander, SP; Hill, SJ; Kendall, DA	1
Edwards, WD; Lefler, BJ; Natale, NR; Palmer, RB; Triggle, DJ	1
Crawford, RD; Johnson, DD; Pedder, SC; Tuchek, JM; Wilcox, RI	1
Herb, A; Keinänen, K; Sakmann, B; Seeburg, PH; Sommer, B; Verdoorn, TA; Werner, P; Wisden, W	1
Markowska, AL; Olton, DS; Wenk, GL	1
Choi, DW; Goldberg, MP; Hartley, DM; Koh, JY	1
Yang, J; Zorumski, CF	1
Weiss, S	1
Everitt, BJ; Jones, GH; Marston, HM; Page, KJ; Robbins, TW; Ryan, CN	1
Cohen, J	1
Horne, AL; Simmonds, MA	1
Everitt, BJ; Jones, GH; Marston, HM; Page, KJ; Robbins, TW; Wilkinson, J	1
King, AE; Nistri, A; Rovira, C	1
Costa, E; Iadarola, MJ; Nicoletti, F; Wroblewski, JT	1
Morgan, IG	1
Murphy, DE; Snowhill, EW; Williams, M	1
Bridges, RJ; Cotman, CW; Kadri, MM; Monaghan, DT; Nunn, PB; Watkins, JC	1
Errami, M; Nieoullon, A	1
Baudry, M; Kessler, M; Lynch, G; Terramani, T	1
Shreve, PE; Uretsky, NJ	1
Cha, JH; Honoré, T; Nielsen, EO; Penney, JB; Young, AB	1
Dunnett, SB; Hastings, MH; Winn, P	1
Hanka, LJ; Martin, DG; Neil, GL	1
Bolt, AG; Ghosh, PB	1
Kerkut, GA; Mat Jais, AM; Walker, RJ	1
Ishida, M; Shinozaki, H	1
Bieger, D; Martin-Caraballo, M; Triggle, CR	1
John, GW; Le Grand, B; Vié, B	1
Abdel-Rahman, SM; Kearns, GL	2
Abdel-Rahman, SM; Blowey, DL; Jacobs, RF; James, LP; Kearns, GL; Marshall, JD; Wells, TG	1
Groarke, JM; Pevear, DC	1
Rotbart, HA	1
Groarke, JM; Pevear, DC; Seipel, ME; Tull, TM	1
Hayden, FG	1
Diana, GD; McKinlay, MA; Rogers, JM	1
Bossart, W; Güngör, T; Lauener, R; Schmugge, M; Seger, RA	1
Le Moing, V	1
Sawyer, MH	3
Schiff, GM; Sherwood, JR	1
Flückiger, U	1
Steele, RW; Yarush, LI	1
John, GW; Le Grand, B; Panissié, A; Pauwels, PJ; Perez, M	1
Crump, CE; Hayden, FG; Kaiser, L	1
Abdel-Rahman, SM; Bradley, JS; Capparelli, EV; Jacobs, RF; James, LP; Johnson, KM; Kearns, GL	1
Ballesteros, F; Reina, J	1
Forman, MS; Lederman, HM; Nowak-Wegrzyn, A; Phipatanakul, W; Winkelstein, JA	1
Turner, RB	1
Rotbart, HA; Webster, AD	1
Romero, JR	1
Nigrovic, LE	1
Ansevin, CF	1
Billich, A	1
Alonso, EM; Aradottir, E; Shulman, ST	1
Black, J; Leeman, B; Mundy, LM; Reed, N; Starlin, R; Trulock, E	1
Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS	1
Chang, CM; Chang, YL; Chen, SJ; Chern, JH; Hsu, MC; Lee, CC; Lee, YC; Leong, MK; Li, WT; Peng, KC; Shia, KS; Shih, SR; Tai, CL; Tseng, HY; Tseng, SN	1
Blatter, MM; Coats, T; Hassman, HA; Hayden, FG; Kim, K; Liu, S; Zhang, B	1
Hirata, M; Kagawa, S; Ohmomo, Y; Yoshimoto, M	1
Senior, K	1
Ashkenazi, S; Bauer, S; Gottesman, G; Levi, I; Litmanovitz, I; Sirota, L	1
Florea, NR; Maglio, D; Nicolau, DP	1
Buscombe, JR; Johnson, MA; Thomson, AP; Tormey, VJ; Webster, AD	1
Abzug, MJ; Blount, S; Bradley, J; Capparelli, EV; Cloud, G; Kimberlin, DW; Lakeman, F; Lepow, M; Mani, C; Powell, D; Romero, J; Sánchez, PJ; Whitley, RJ	1
Andrews, PI; Bye, AM; Craig, ME; Lahra, MM; Nolan, MA; Prager, PC; Rawlinson, WD; Williams, GD	1
Coats, TL; Collett, M; Cooper, EC; Hayden, FG; Herrington, DT; Hudson, S; Kim, K; Liu, S; McKinlay, M; Pevear, DC; Villano, SA	1
Andrews, IP; Nolan, M; Prager, P; Williams, GD	1
BALLONOFF, LB; FEINSTEIN, RN; SEAHOLM, JE	1
AIELLO, T; FABRA, J; SPRIO, V	1
GISSELBRECHT, H; LONGCHAMP, D	1
Chase, E; Harris, K; Katpally, U; Reisdorph, N; Siuzdak, G; Smith, TJ; Thomas, JJ	1
Fleischer, R; Laessig, K	1
Abzug, MJ	2
Bryant, PA; Curtis, N; Dargaville, PA; Starr, M; Tingay, D	1
Collett, MS; Demenczuk, TM; Herbertz, T; Ledford, RM; Patel, NR; Pevear, DC; Watanyar, A	1
Bator, CM; Chakravarty, S; Demenczuk, TM; Ledford, RM; Pevear, DC; Rossmann, MG; Simpson, AA; Skochko, GA; Watanyar, A; Zhang, Y	1
Webster, AD	1
Altura, BM; Altura, BT; Li, J; Li, W	1
Freydank, A; Orgzall, I; Schulz, B; Xü, C	1
Birch-Hirschfeld, E; Hammerschmidt, E; Makarov, VA; Riabova, OB; Schmidtke, M; Schüler, S; Wutzler, P; Zell, R	1
Collett, MS; Ledford, RM; Pevear, DC	1
Barone, LR; Collett, MS; Demenczuk, TM; Hayden, FG; McKinlay, MA; Pevear, DC	1
Bertino, JS; Gartung, AM; Liu, S; Ma, JD; Nafziger, AN; Rhodes, G	1
Bertino, JS; Liu, S; Ma, JD; Nafziger, AN; Rhodes, G	1
Byington, CL; Fujinami, RS; Libbey, JE; Rentz, AC; Whitby, FG	1
Accortt, NA; Desmond, RA; Soong, SJ; Talley, L; Villano, SA; Whitley, RJ	1
Berg, AK; Frisk, G; Korsgren, O; Olsson, A	1
Buckheit, RW; Clercq, ED; Cullen, MD; Cushman, M; Deng, BL; Hartman, TL; Pannecouque, C; Watson, KM	1
Da Settimo, F; La Motta, C; Limongelli, V; Marinelli, L; Marini, AM; Novellino, E; Salerno, S; Sartini, S; Simorini, F; Taliani, S	1
Anderson, KS; Bailey, CM; Domaoal, RA; Jorgensen, WL; Leung, CS; Thakur, VV; Tirado-Rives, J; Wang, L; Zeevaart, JG	1
Makarov, VA; Riabova, OB; Schmidtke, M; Wutzler, P; Zieger, R	1
Borowski, P; Ksiazek, A; Wolinski, K	1
Li, Y; Liu, S; Wang, Q; Zhao, Q	1
Berggren, PO; Blixt, M; Holmberg, R; Juntti-Berggren, L; Klitz, W; Niklasson, B	1
Al-Abed, Y; Coco, M; Donia, M; Korac, A; Libra, M; Maksimovic-Ivanic, D; McCubrey, J; Mijatovic, S; Miljkovic, D; Nicoletti, F; Stosic-Grujicic, S; Timotijevic, G	1
Baek, SH; Choi, HJ; Kwon, DH; Lim, CH; Song, JH	1
Bani, M; Beaver, JD; Comley, RA; Griffante, C; Gunn, R; Houle, S; Laruelle, M; Merlo-Pich, E; Mugnaini, M; Rabiner, EA; Searle, G; Slifstein, M; Tziortzi, A; Wilson, AA	1
Cardosa, MJ; Lewthwaite, P; Ooi, MH; Solomon, T; Wong, SC	1
Harvala, H; Pajkrt, D; Wildenbeest, JG; Wolthers, KC	1
Greenwood, V	1
Habara, Y; Moustafa, A; Sakamoto, KQ	1
Chang, S; Joseph, J; Kim, JY	1
Boelens, JJ; Douma, JW; Rademaker, C; Sanders, EA; van de Ven, AA; van Loon, AM; van Montfrans, JM; Wensing, AM	1
Chen, K; Hu, Y; Li, QS; Lu, X; Yan, R; Zhu, HL	1
Cao, Q; Deng, Y; Ding, C; Feng, D; Gu, B; Hu, W; Wang, J; Xie, F; Yao, K; Zhang, C; Zhang, G; Zhou, F	1
Benschop, KS; Koen, G; Kuijpers, TW; van den Broek, PJ; Vossen, AC; Wierenga, PC; Wildenbeest, JG; Wolthers, KC	1
Hussain Basha, S; Prasad, RN	1
Gong, YD; Kwak, HJ; Lee, SH; Yang, SJ	1
Beattie, D; Chen, Q; Clough, J; Gu, YC; Irwin, D; Mulholland, N; Yang, GF; Zhang, MZ	1
Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M	1
Benschop, KSM; Koen, G; Minnaar, RP; Pajkrt, D; van den Broek, PJ; van Hemert, FJ; Vossen, ACTM; Westerhuis, BM; Wildenbeest, JG; Wolthers, KC	1
El-Badri, F; Hu, B; Hudson, BM; Kurth, MJ; Phuan, PW; Tantillo, DJ; Verkman, AS; Ye, L	1
Fokine, A; Kihara, D; Kuhn, RJ; Liu, Y; Long, F; Meng, G; Rossmann, MG; Sheng, J; Shin, WH	1
Bernard, A; Cabiddu, MG; Lacroix, C; Leyssen, P; Neyts, J; Pompei, R	1
Kheylik, Y; Kondratov, I; Krasavin, M; Naumchyk, V; Platonov, M; Zahanich, I; Zozulya, S	1
Angius, F; Coluccia, A; Laconi, S; Lacroix, C; Leyssen, P; Neyts, J; Pompei, R; Silvestri, R	1
Galabov, AS; Nikolova, I; Stoyanova, A	1
Baggen, J; Delang, L; Froeyen, M; George, S; Hilgenfeld, R; Leyssen, P; Meijer, A; Neyts, J; Sun, L; Thibaut, HJ; van Kuppeveld, FJ; Vernachio, J; Zhang, L	1
Braun, H; Glen, RC; Kirchmair, J; Makarov, VA; Riabova, OB; Sauerbrei, A; Schmidtke, M; Williamson, MJ	1
Abzug, MJ; Acosta, EP; Cloud, G; Dennehy, P; Jacobs, RF; Jester, P; Kimberlin, D; Krogstad, P; Lawrence, R; Michaels, MG; Palmer, A; Robinson, J; Romero, JR; Sánchez, PJ; Shelton, M; Sood, SK; Storch, GA; Wald, E; Whitley, R; Wilson, G	1
Häkkinen, H; Lahtinen, T; Malola, S; Marjomäki, V; Martikainen, M; Permi, P; Salorinne, K	1
Cheng, XY; Jiang, JD; Kong, LY; Li, YH; Song, DQ; Tang, S; Wang, HQ; Zhang, X	1
Day, CW; Evans, WJ; Nicolaou, KC; Smee, DF; Tarbet, EB	1
Hernández, M	1
Muller, WJ	1
Dimitrov, V; Dobrikov, G; Galabov, AS; Nikolova, I; Philipov, S; Pürstinger, G; Stoyanova, A	1
Groenhof, G; Häkkinen, H; Malola, S; Pohjolainen, E	1
Abdelnabi, R; Delang, L; Froeyen, M; Luyten, W; Ma, Y; Mirabelli, C; Neyts, J	1
Baršić, B; Kutleša, M; Radanović, I; Rkman, D; Zekan, P	1
DeBiasi, RL; Harik, N	1
Lv, W; Wang, Y; Zhang, M; Zhang, Y	1
Blaas, D; Goessweiner-Mohr, N; Kirchmair, J; Makarov, VA; Marlovits, TC; Mathai, N; Pasin, M; Real-Hohn, A; Richter, M; Schmidtke, M; Verdaguer, N; Wald, J; Walther, C; Zanella, I	1
Honkimaa, A; Hyöty, H; Sioofy-Khojine, AB	1
Egorova, A; Ekins, S; Jahn, B; Kazakova, E; Makarov, V; Schmidtke, M	1
Dong, HQ; Gu, YC; Guo, SK; Han, X; Liu, JR; Song, ZL; Sun, Q; Zhang, MZ; Zhang, WH; Zhu, Y	1
Egorova, A; Ekins, S; Galochkina, A; Makarov, V; Volobueva, A; Zarubaev, V	1
Berggren, PO; Juntti-Berggren, L; Klitz, W; Lindquist, L; Niklasson, B	1
Galabov, AS; Stoyanova, A	1
Füzik, T; Kalynych, S; Moravcová, J; Plevka, P	1
Andricopulo, AD; Coelho, F; Ferreira, LLG; Teles, HR; Valli, M	1

Reviews

21 review(s) available for oxazoles and oxadiazoles

Article	Year
Antiviral therapy for enteroviral infections. The Pediatric infectious disease journal, 1999, Volume: 18, Issue:7 Topics: Adult; Antiviral Agents; Enterovirus Infections; Humans; Immunization, Passive; Infant, Newborn; Oxadiazoles; Oxazoles; Randomized Controlled Trials as Topic	1999
Update on influenza and rhinovirus infections. Advances in experimental medicine and biology, 1999, Volume: 458 Topics: Acetamides; Amines; Antiviral Agents; Common Cold; Guanidines; Humans; Influenza, Human; Intercellular Adhesion Molecule-1; Neuraminidase; Oseltamivir; Oxadiazoles; Oxazoles; Picornaviridae Infections; Pyrans; Recombinant Proteins; Rhinovirus; Sialic Acids; Zanamivir	1999
Pleconaril. A broad spectrum antipicornaviral agent. Advances in experimental medicine and biology, 1999, Volume: 458 Topics: Antiviral Agents; Enterovirus; Humans; Meningitis, Viral; Oxadiazoles; Oxazoles; Picornaviridae Infections	1999
Enterovirus infections: diagnosis and treatment. The Pediatric infectious disease journal, 1999, Volume: 18, Issue:12 Topics: Antiviral Agents; Child; Cost of Illness; Enterovirus; Enterovirus Infections; Humans; Meningitis, Viral; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Serologic Tests	1999
[On new antiviral drugs, new viruses and old known bacteria]. Schweizerische medizinische Wochenschrift, 1999, Dec-28, Volume: 129, Issue:51-52 Topics: Anti-Bacterial Agents; Antiviral Agents; Bacteria; Bacterial Infections; Enterovirus; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles; Virus Diseases; Viruses	1999
[Pleconaril, a new aniviral drug with activity against picornavirus]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia, 2000, Volume: 13, Issue:3 Topics: Animals; Antiviral Agents; Drug Resistance; Humans; Oxadiazoles; Oxazoles; Picornaviridae; Picornaviridae Infections	2000
The treatment of rhinovirus infections: progress and potential. Antiviral research, 2001, Volume: 49, Issue:1 Topics: 3C Viral Proteases; Antiviral Agents; Clinical Trials as Topic; Combined Modality Therapy; Common Cold; Cysteine Endopeptidases; Dietary Supplements; Drug Therapy, Combination; Echinacea; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Phytotherapy; Picornaviridae Infections; Plant Extracts; Plants, Medicinal; Pyrrolidinones; Receptors, Virus; Rhinovirus; Valine; Viral Proteins; Zinc	2001
Enterovirus infections: diagnosis and treatment. Current opinion in pediatrics, 2001, Volume: 13, Issue:1 Topics: Adolescent; Adult; Antiviral Agents; Child; Child, Preschool; Enterovirus Infections; Female; Humans; Infant; Infant, Newborn; Meningitis, Viral; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious; Sepsis	2001
What's new with enteroviral infections? Current opinion in pediatrics, 2001, Volume: 13, Issue:1 Topics: Antiviral Agents; Cost-Benefit Analysis; Disease Outbreaks; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Romania; Scotland	2001
Pleconaril Sanofi Synthélabo/ViroPharma. Current opinion in investigational drugs (London, England : 2000), 2000, Volume: 1, Issue:3 Topics: Antiviral Agents; Clinical Trials as Topic; Contraindications; Drugs, Investigational; Humans; Oxadiazoles; Oxazoles; Picornaviridae; Picornaviridae Infections; Structure-Activity Relationship	2000
Biotransformation reactions of five-membered aromatic heterocyclic rings. Chemical research in toxicology, 2002, Volume: 15, Issue:3 Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics	2002
Enterovirus infections: diagnosis and treatment. Seminars in pediatric infectious diseases, 2002, Volume: 13, Issue:1 Topics: Adult; Antiviral Agents; Child; Clinical Trials as Topic; Enterovirus Infections; Humans; Meningitis, Viral; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Virus Replication	2002
Pleconaril, a novel antipicornaviral agent. Pharmacotherapy, 2003, Volume: 23, Issue:3 Topics: Adolescent; Adult; Aged; Antiviral Agents; Area Under Curve; Biological Availability; Half-Life; Humans; Middle Aged; Oxadiazoles; Oxazoles; Picornaviridae Infections; Randomized Controlled Trials as Topic	2003
Presentation, diagnosis, and management of enterovirus infections in neonates. Paediatric drugs, 2004, Volume: 6, Issue:1 Topics: Adult; Antiviral Agents; Child; Enterovirus Infections; Humans; Infant, Newborn; Oxadiazoles; Oxazoles; Randomized Controlled Trials as Topic; Viral Vaccines	2004
Pleconaril--an advance in the treatment of enteroviral infection in immuno-compromised patients. Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2005, Volume: 32, Issue:1 Topics: Antiviral Agents; Enterovirus Infections; Humans; Immunocompromised Host; Oxadiazoles; Oxazoles; Poliovirus	2005
Self-organization of substituted 1,3,4-oxadiazoles in the solid state and at surfaces. Advances in colloid and interface science, 2005, Nov-30, Volume: 116, Issue:1-3 Topics: Computer Simulation; Crystallization; Crystallography, X-Ray; Membranes, Artificial; Models, Molecular; Molecular Structure; Oxadiazoles; Oxazoles; Surface Properties	2005
Clinical features, diagnosis, and management of enterovirus 71. The Lancet. Neurology, 2010, Volume: 9, Issue:11 Topics: Disease Management; Enterovirus A, Human; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles	2010
The need for treatment against human parechoviruses: how, why and when? Expert review of anti-infective therapy, 2010, Volume: 8, Issue:12 Topics: Animals; Antiviral Agents; Central Nervous System Infections; Disease Models, Animal; Humans; Infant, Newborn; Oxadiazoles; Oxazoles; Parechovirus; Picornaviridae Infections; Sepsis	2010
The enteroviruses: problems in need of treatments. The Journal of infection, 2014, Volume: 68 Suppl 1 Topics: Antiviral Agents; Drug Discovery; Enterovirus Infections; Global Health; Humans; Oxadiazoles; Oxazoles	2014
Treatment of perinatal viral infections to improve neurologic outcomes. Pediatric research, 2017, Volume: 81, Issue:1-2 Topics: Acyclovir; Antiviral Agents; Brain; Cognition; Cognition Disorders; Encephalitis, Herpes Simplex; Enterovirus Infections; Female; Ganciclovir; HIV Infections; Humans; Infant, Newborn; Nervous System Diseases; Oxadiazoles; Oxazoles; Pregnancy; Valganciclovir; Virus Diseases	2017
Neonatal nonpolio enterovirus and parechovirus infections. Seminars in perinatology, 2018, Volume: 42, Issue:3 Topics: Antiviral Agents; Cross Infection; Enterovirus; Enterovirus Infections; Female; Fomites; Humans; Infant, Newborn; Infectious Disease Transmission, Vertical; Oxadiazoles; Oxazoles; Parechovirus; Phenyl Ethers; Picornaviridae Infections; Polymerase Chain Reaction; Pregnancy; Pregnancy Complications, Infectious	2018

Trials

15 trial(s) available for oxazoles and oxadiazoles

Article	Year
Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution and effect of food. Antimicrobial agents and chemotherapy, 1998, Volume: 42, Issue:10 Topics: Administration, Oral; Adolescent; Adult; Antiviral Agents; Cross-Over Studies; Food; Humans; Oxadiazoles; Oxazoles; Picornaviridae; Solutions	1998
Single-dose pharmacokinetics of a pleconaril (VP63843) oral solution in children and adolescents. Pediatric Pharmacology Research Unit Network. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:3 Topics: Administration, Oral; Aging; Antiviral Agents; Area Under Curve; Child; Child, Preschool; Female; Humans; Male; Oxadiazoles; Oxazoles; Pharmaceutical Solutions	1999
Single oral dose escalation pharmacokinetics of pleconaril (VP 63843) capsules in adults. Journal of clinical pharmacology, 1999, Volume: 39, Issue:6 Topics: Administration, Oral; Adult; Antiviral Agents; Area Under Curve; Capsules; Dose-Response Relationship, Drug; Double-Blind Method; Dyspepsia; Humans; Male; Middle Aged; Oxadiazoles; Oxazoles; Single-Blind Method	1999
Clinical activity of pleconaril in an experimentally induced coxsackievirus A21 respiratory infection. The Journal of infectious diseases, 2000, Volume: 181, Issue:1 Topics: Adolescent; Adult; Antibodies, Viral; Antiviral Agents; Coxsackievirus Infections; Enterovirus; Female; Humans; Male; Middle Aged; Mucus; Nose; Oxadiazoles; Oxazoles; Respiratory Tract Infections; Virus Shedding	2000
Single dose pharmacokinetics of pleconaril in neonates. Pediatric Pharmacology Research Unit Network. The Pediatric infectious disease journal, 2000, Volume: 19, Issue:9 Topics: Administration, Oral; Age Factors; Antiviral Agents; Area Under Curve; Biological Availability; Enterovirus Infections; Female; Humans; Infant, Newborn; Male; Oxadiazoles; Oxazoles	2000
Treatment of potentially life-threatening enterovirus infections with pleconaril. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001, Jan-15, Volume: 32, Issue:2 Topics: Adolescent; Adult; Aged; Antiviral Agents; Child; Child, Preschool; Chronic Disease; Enterovirus; Enterovirus Infections; Follow-Up Studies; Humans; Infant, Newborn; Meningoencephalitis; Middle Aged; Oxadiazoles; Oxazoles; Treatment Outcome	2001
Oral pleconaril treatment of picornavirus-associated viral respiratory illness in adults: efficacy and tolerability in phase II clinical trials. Antiviral therapy, 2002, Volume: 7, Issue:1 Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Double-Blind Method; Female; Humans; Male; Middle Aged; Oxadiazoles; Oxazoles; Picornaviridae Infections; Respiratory Tract Infections; Virus Shedding	2002
Severe Coxsackie virus B infection in preterm newborns treated with pleconaril. European journal of pediatrics, 2002, Volume: 161, Issue:9 Topics: Antiviral Agents; Coxsackievirus Infections; Diseases in Twins; Enterovirus B, Human; Female; Humans; Infant, Newborn; Infant, Premature; Oxadiazoles; Oxazoles	2002
Double blind placebo-controlled trial of pleconaril in infants with enterovirus meningitis. The Pediatric infectious disease journal, 2003, Volume: 22, Issue:4 Topics: Administration, Oral; Biological Availability; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Enterovirus Infections; Female; Follow-Up Studies; Humans; Infant; Male; Meningitis, Viral; Oxadiazoles; Oxazoles; Probability; Reference Values; Risk Assessment; Severity of Illness Index; Treatment Outcome	2003
Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Jun-15, Volume: 36, Issue:12 Topics: Administration, Oral; Adult; Antiviral Agents; Common Cold; Diarrhea; Double-Blind Method; Female; Humans; Male; Nausea; Oxadiazoles; Oxazoles; Picornaviridae; Picornaviridae Infections; Prospective Studies; Treatment Outcome	2003
Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses. Antimicrobial agents and chemotherapy, 2005, Volume: 49, Issue:11 Topics: Antiviral Agents; Common Cold; Double-Blind Method; Drug Resistance, Bacterial; Humans; Oxadiazoles; Oxazoles; Rhinovirus	2005
The effect of oral pleconaril on hepatic cytochrome P450 3A activity in healthy adults using intravenous midazolam as a probe. Journal of clinical pharmacology, 2006, Volume: 46, Issue:1 Topics: Administration, Oral; Adult; Antiviral Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Humans; Injections, Intravenous; Liver; Male; Midazolam; Oxadiazoles; Oxazoles	2006
Enteroviral meningitis: natural history and outcome of pleconaril therapy. Antimicrobial agents and chemotherapy, 2006, Volume: 50, Issue:7 Topics: Adult; Antiviral Agents; Double-Blind Method; Enterovirus Infections; Female; Headache; Humans; Male; Meningitis, Viral; Multivariate Analysis; Oxadiazoles; Oxazoles; Treatment Outcome	2006
A Randomized, Double-Blind, Placebo-Controlled Trial of Pleconaril for the Treatment of Neonates With Enterovirus Sepsis. Journal of the Pediatric Infectious Diseases Society, 2016, Volume: 5, Issue:1 Topics: Antiviral Agents; Double-Blind Method; Enterovirus; Enterovirus Infections; Female; Humans; Infant; Infant, Newborn; Male; Neonatal Sepsis; Oropharynx; Oxadiazoles; Oxazoles; Rectum	2016
[A randomized, double-blind, placebo-controlled trial of pleconaril for the treatment of neonates with enterovirus sepsis]. Revista chilena de infectologia : organo oficial de la Sociedad Chilena de Infectologia, 2016, Volume: 33, Issue:3 Topics: Antiviral Agents; Double-Blind Method; Enterovirus Infections; Female; Humans; Infant, Newborn; Male; Neonatal Sepsis; Oxadiazoles; Oxazoles; Placebo Effect; Reproducibility of Results; Time Factors; Treatment Outcome	2016

Other Studies

111 other study(ies) available for oxazoles and oxadiazoles

Article	Year
Effects of ibotenic acid, quisqualic acid and their relatives on the excitability of an identifiable giant neurone of an African giant snail (Achatina fulica Férussac). Experientia, 1977, Mar-15, Volume: 33, Issue:3 Topics: Alanine; Animals; Glutamates; Ibotenic Acid; Neurons; Oxadiazoles; Oxazoles; Snails; Structure-Activity Relationship	1977
Autoradiographic characterization and localization of quisqualate binding sites in rat brain using the antagonist [3H]6-cyano-7-nitroquinoxaline-2,3-dione: comparison with (R,S)-[3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding sites. Journal of neurochemistry, 1990, Volume: 54, Issue:2 Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Binding Sites; Brain; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Male; Oxadiazoles; Oxazoles; Quinoxalines; Quisqualic Acid; Rats; Rats, Inbred Strains; Tissue Distribution	1990
Further characterisation of excitatory amino acid receptors coupled to phosphoinositide metabolism in astrocytes. Neuroscience letters, 1990, Jun-08, Volume: 113, Issue:3 Topics: Astrocytes; Cells, Cultured; Glutamates; Glutamic Acid; Ibotenic Acid; Neurotransmitter Agents; Oxadiazoles; Oxazoles; Phosphatidylinositols; Quisqualic Acid; Receptors, Amino Acid; Receptors, Cell Surface	1990
Excitatory amino acid-induced formation of inositol phosphates in guinea-pig cerebral cortical slices: involvement of ionotropic or metabotropic receptors? Journal of neurochemistry, 1990, Volume: 55, Issue:4 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Calcium Chloride; Carbachol; Cerebral Cortex; Cycloleucine; Glutamates; Glutamic Acid; Ibotenic Acid; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Kinetics; Mice; Oxadiazoles; Oxazoles; Potassium Chloride; Quisqualic Acid; Receptors, Glutamate; Receptors, Neurotransmitter	1990
4-Isoxazolyl-1,4-dihydropyridines: biological, theoretical, and structural studies. Journal of medicinal chemistry, 1990, Volume: 33, Issue:8 Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Crystallization; Dihydropyridines; Guinea Pigs; Ileum; Isoxazoles; Isradipine; Molecular Conformation; Molecular Structure; Myocardium; Oxadiazoles; Oxazoles; Structure-Activity Relationship; X-Ray Diffraction	1990
Quisqualate receptors in epileptic fowl: the absence of coupling between quisqualate and N-methyl-D-aspartate receptors. European journal of pharmacology, 1990, Jan-03, Volume: 175, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Chickens; Convulsants; Dose-Response Relationship, Drug; Epilepsy; Ibotenic Acid; Kinetics; Oxadiazoles; Oxazoles; Quisqualic Acid; Radioligand Assay; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1990
A family of AMPA-selective glutamate receptors. Science (New York, N.Y.), 1990, Aug-03, Volume: 249, Issue:4968 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Base Sequence; Brain; Glutamates; Ibotenic Acid; Kainic Acid; Kinetics; Molecular Sequence Data; Multigene Family; Oligonucleotide Probes; Organ Specificity; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Receptors, Glutamate; Receptors, Neurotransmitter; RNA, Messenger; Sequence Homology, Nucleic Acid	1990
Nucleus basalis magnocellularis and memory: differential effects of two neurotoxins. Behavioral and neural biology, 1990, Volume: 54, Issue:1 Topics: Animals; Basal Ganglia; Brain Mapping; Cerebral Cortex; Cholinergic Fibers; Convulsants; Cues; Discrimination Learning; Ibotenic Acid; Male; Memory; Mental Recall; Motivation; Neural Pathways; Orientation; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Retention, Psychology	1990
Non-NMDA receptor-mediated neurotoxicity in cortical culture. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1990, Volume: 10, Issue:2 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Cells, Cultured; Cerebral Cortex; Drug Synergism; Ibotenic Acid; Kainic Acid; Microscopy, Phase-Contrast; Neurons; Oxadiazoles; Oxazoles; Quisqualic Acid; Time Factors; Zinc	1990
AMPA, kainate, and quisqualate activate a common receptor-channel complex on embryonic chick motoneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience, 1988, Volume: 8, Issue:11 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Animals; Binding, Competitive; Chick Embryo; Ibotenic Acid; Ion Channels; Kainic Acid; Motor Neurons; Oxadiazoles; Oxazoles; Quisqualic Acid; Receptors, Cell Surface	1988
Two distinct quisqualate receptor systems are present on striatal neurons. Brain research, 1989, Jul-03, Volume: 491, Issue:1 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Corpus Striatum; gamma-Aminobutyric Acid; Ibotenic Acid; Inositol Phosphates; Mice; Oxadiazoles; Oxazoles; Quisqualic Acid; Receptors, AMPA; Receptors, Neurotransmitter	1989
Comparative effects of quisqualic and ibotenic acid-induced lesions of the substantia innominata and globus pallidus on the acquisition of a conditional visual discrimination: differential effects on cholinergic mechanisms. Neuroscience, 1989, Volume: 28, Issue:2 Topics: Animals; Basal Ganglia; Behavior, Animal; Biomechanical Phenomena; Brain Diseases; Conditioning, Psychological; Discrimination Learning; Globus Pallidus; Ibotenic Acid; Male; Oxadiazoles; Oxazoles; Parasympathetic Nervous System; Quisqualic Acid; Rats; Rats, Inbred Strains; Substantia Innominata; Visual Perception	1989
Comparative effects of kainic, quisqualic, and ibotenic acids on phenylethanolamine-N-methyltransferase-containing cells of rat retina. Toxicology, 1989, Volume: 54, Issue:2 Topics: Animals; Choline O-Acetyltransferase; Ibotenic Acid; Kainic Acid; Male; Organ Size; Oxadiazoles; Oxazoles; Phenylethanolamine N-Methyltransferase; Quisqualic Acid; Rats; Rats, Inbred Strains; Retina	1989
The pharmacology of quisqualate and AMPA in the cerebral cortex of the rat in vitro. Neuropharmacology, 1989, Volume: 28, Issue:10 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Interactions; Glutamine; Ibotenic Acid; In Vitro Techniques; Kynurenic Acid; Male; Neuromuscular Depolarizing Agents; Oxadiazoles; Oxazoles; Pentobarbital; Quisqualic Acid; Rats; Rats, Inbred Strains; Taurine	1989
Comparative effects of ibotenic acid- and quisqualic acid-induced lesions of the substantia innominata on attentional function in the rat: further implications for the role of the cholinergic neurons of the nucleus basalis in cognitive processes. Behavioural brain research, 1989, Dec-01, Volume: 35, Issue:3 Topics: Animals; Attention; Basal Ganglia; Cholinergic Fibers; Cognition; Ibotenic Acid; Male; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Substantia Innominata	1989
The excitation of frog motoneurones in vitro by the glutamate analogue, DI-alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA), and the effect of amino acid antagonists. Neuroscience letters, 1985, Mar-22, Volume: 55, Issue:1 Topics: 2-Amino-5-phosphonovalerate; 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Dicarboxylic; Animals; Glutamates; Glutamic Acid; Ibotenic Acid; Membrane Potentials; Motor Neurons; Oxadiazoles; Oxazoles; Quisqualic Acid; Rana temporaria; Receptors, AMPA; Receptors, Drug; Spinal Cord; Synapses; Synaptic Transmission; Valine	1985
Excitatory amino acid recognition sites coupled with inositol phospholipid metabolism: developmental changes and interaction with alpha 1-adrenoceptors. Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:6 Topics: Age Factors; Aminobutyrates; Animals; Aspartic Acid; Drug Interactions; Glutamates; Glutamic Acid; Hippocampus; Hydrolysis; Ibotenic Acid; Norepinephrine; Oxadiazoles; Oxazoles; Phosphatidylinositols; Phosphoserine; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Amino Acid; Receptors, Cell Surface	1986
AMPA is a powerful neurotoxin in the chicken retina. Neuroscience letters, 1987, Aug-31, Volume: 79, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Chickens; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Ibotenic Acid; Injections; Kainic Acid; N-Methylaspartate; Nerve Degeneration; Oxadiazoles; Oxazoles; Quisqualic Acid; Retina; Retinal Ganglion Cells; Vitreous Body	1987
Characterization of quisqualate recognition sites in rat brain tissue using DL-[3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) and a filtration assay. Neurochemical research, 1987, Volume: 12, Issue:9 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Chemical Phenomena; Chemistry; Filtration; Glutamates; Glutamic Acid; Ibotenic Acid; Male; Oxadiazoles; Oxazoles; Quisqualic Acid; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Thiocyanates	1987
Inhibition of [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding by the excitotoxin beta-N-oxalyl-L-alpha,beta-diaminopropionic acid. European journal of pharmacology, 1988, Jan-19, Volume: 145, Issue:3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids, Diamino; Animals; Brain; Ibotenic Acid; In Vitro Techniques; Oxadiazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Synaptic Membranes; Toxins, Biological	1988
alpha-[3H]Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid binding to rat striatal membranes: effects of selective brain lesions. Journal of neurochemistry, 1988, Volume: 51, Issue:2 Topics: 3,4-Dihydroxyphenylacetic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding Sites; Choline O-Acetyltransferase; Corpus Striatum; Denervation; Dopamine; Glutamate Decarboxylase; Glutamates; Glutamic Acid; Ibotenic Acid; Membranes; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains	1988
Effects of thiol-reagents on [3H]alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid binding to rat telencephalic membranes. Molecular pharmacology, 1988, Volume: 34, Issue:2 Topics: Allosteric Regulation; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cell Membrane; Ibotenic Acid; Male; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug; Receptors, Glutamate; Receptors, Neurotransmitter; Sulfhydryl Reagents; Telencephalon	1988
Role of quisqualic acid receptors in the hypermotility response produced by the injection of AMPA into the nucleus accumbens. Pharmacology, biochemistry, and behavior, 1988, Volume: 30, Issue:2 Topics: 2-Aminoadipic Acid; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Aspartic Acid; Glutamates; Glutamine; Ibotenic Acid; Injections; Kainic Acid; Locomotion; Male; N-Methylaspartate; Nucleus Accumbens; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Drug	1988
Thiocyanate stabilizes AMPA binding to the quisqualate receptor. European journal of pharmacology, 1988, Nov-22, Volume: 157, Issue:2-3 Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Autoradiography; Brain; Calcium; Chlorides; Coloring Agents; Glutamates; Ibotenic Acid; Ligands; Male; Oxadiazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, AMPA; Receptors, Glutamate; Receptors, Neurotransmitter; Thiocyanates	1988
Neurotoxic amino acid lesions of the lateral hypothalamus: a parametric comparison of the effects of ibotenate, N-methyl-D,L-aspartate and quisqualate in the rat. Brain research, 1985, Dec-23, Volume: 360, Issue:1-2 Topics: Animals; Aspartic Acid; Dopamine; Hypothalamic Area, Lateral; Ibotenic Acid; Male; Mesencephalon; N-Methylaspartate; Neural Pathways; Oxadiazoles; Oxazoles; Quisqualic Acid; Rats; Rats, Inbred Strains; Serotonin	1985
A new antitumor antimetabolite, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (NSC-163501): antimicrobial reversal studies and preliminary evaluation against L1210 mouse leukemia in vivo. Cancer chemotherapy reports, 1973, Volume: 57, Issue:2 Topics: Animals; Antibiotics, Antineoplastic; Bacillus subtilis; Leukemia L1210; Leukemia, Experimental; Mice; Oxadiazoles; Oxazoles	1973
Benzo-2,1,5-oxadiazoles--a novel class of heterocyclic monoamine oxidase inhibitors. Biochemical pharmacology, 1974, Jul-15, Volume: 23, Issue:14 Topics: Animals; Carbon Radioisotopes; In Vitro Techniques; Kinetics; Male; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Oxazoles; Rats; Structure-Activity Relationship; Thiadiazoles; Thiazoles; Tryptamines	1974
The ionic mechanisms associated with the excitatory response of kainate, L-glutamate, quisqualate, ibotenate, AMPA and methyltetrahydrofolate on leech Retzius cells. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1984, Volume: 77, Issue:1 Topics: Action Potentials; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cell Membrane; Cell Membrane Permeability; Ganglia; Glutamates; Glutamic Acid; Ibotenic Acid; Kainic Acid; Leeches; Membrane Potentials; Neurons; Osmolar Concentration; Oxadiazoles; Oxazoles; Pyrrolidines; Quisqualic Acid; Sodium; Tetrahydrofolates	1984
Electrophysiological studies of kainate, quisqualate, and ibotenate action on the crayfish neuromuscular junction. Advances in biochemical psychopharmacology, 1981, Volume: 27 Topics: Alanine; Animals; Astacoidea; Electrophysiology; Ibotenic Acid; In Vitro Techniques; Kainic Acid; Neuromuscular Junction; Oxadiazoles; Oxazoles; Picrotoxin; Pyrrolidines; Quisqualic Acid	1981
Photosensitization of oesophageal smooth muscle by 3-NO2-1, 4-dihydropyridines: evidence for two cyclic GMP-dependent effector pathways. British journal of pharmacology, 1995, Volume: 116, Issue:8 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3',5'-Cyclic-GMP Phosphodiesterases; Aminoquinolines; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium-Transporting ATPases; Chelating Agents; Egtazic Acid; Esophagus; Guanylate Cyclase; In Vitro Techniques; Indoles; Marine Toxins; Muscle, Smooth; Nicotinic Acids; Nitric Oxide; Oxadiazoles; Oxazoles; Phosphoprotein Phosphatases; Photosensitizing Agents; Purinones; Rats; Rats, Sprague-Dawley; Ryanodine	1995
Effects of sumatriptan on coronary flow and left ventricular function in the isolated perfused guinea pig heart. Journal of cardiovascular pharmacology, 1998, Volume: 32, Issue:3 Topics: Animals; Coronary Circulation; Diastole; Dihydroergotamine; Endothelium, Vascular; Guinea Pigs; In Vitro Techniques; NG-Nitroarginine Methyl Ester; Oxadiazoles; Oxazoles; Oxazolidinones; Perfusion; Piperazines; Rabbits; Receptor, Serotonin, 5-HT1B; Receptor, Serotonin, 5-HT1D; Receptors, Serotonin; Serotonin Receptor Agonists; Sumatriptan; Tryptamines; Ventricular Function, Left	1998
Attenuated virulence of pleconaril-resistant coxsackievirus B3 variants. The Journal of infectious diseases, 1999, Volume: 179, Issue:6 Topics: Animals; Antiviral Agents; Binding Sites; Capsid; Capsid Proteins; Drug Resistance, Microbial; Enterovirus B, Human; Genetic Variation; Male; Mice; Mice, Inbred BALB C; Oxadiazoles; Oxazoles; RNA, Viral; Sequence Analysis, RNA	1999
Activity of pleconaril against enteroviruses. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:9 Topics: Animals; Animals, Newborn; Animals, Suckling; Antiviral Agents; Cells, Cultured; Coxsackievirus Infections; Enterovirus; Female; Humans; Male; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Oxadiazoles; Oxazoles; Serotyping; Virus Replication	1999
Chronic enteroviral meningo-encephalitis in X-linked agammaglobulinaemia: favourable response to anti-enteroviral treatment. European journal of pediatrics, 1999, Volume: 158, Issue:12 Topics: Adult; Agammaglobulinemia; Antiviral Agents; Enterovirus; Genetic Linkage; Humans; Male; Meningoencephalitis; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; X Chromosome	1999
[New antivirals for respiratory tract viruses]. Presse medicale (Paris, France : 1983), 1999, Nov-27, Volume: 28 Suppl 3 Topics: Antiviral Agents; Drug Approval; France; Guanidines; Humans; Influenza, Human; Neuraminidase; Oxadiazoles; Oxazoles; Picornaviridae Infections; Pyrans; Respiratory Tract Infections; Sialic Acids; Zanamivir	1999
Diagnosis and prospective treatment of enteroviral infections in children. Clinical pediatrics, 2000, Volume: 39, Issue:4 Topics: Antiviral Agents; Child; Diagnosis, Differential; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral	2000
Zolmitriptan stimulates a Ca(2+)-dependent K(+) current in C6 glioma cells stably expressing recombinant human 5-HT(1B) receptors. European journal of pharmacology, 2000, Jun-02, Volume: 397, Issue:2-3 Topics: Animals; Calcium; Dose-Response Relationship, Drug; Humans; Membrane Potentials; Oxadiazoles; Oxazoles; Oxazolidinones; Peptides; Piperazines; Potassium Channels; Receptor, Serotonin, 5-HT1B; Receptors, Serotonin; Recombinant Fusion Proteins; Serotonin Antagonists; Serotonin Receptor Agonists; Tetraethylammonium; Tryptamines; Tumor Cells, Cultured	2000
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses. Antiviral research, 2000, Volume: 47, Issue:3 Topics: Antiviral Agents; Cell Survival; Cells, Cultured; Common Cold; Humans; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; Spectrophotometry; Valine	2000
Successful treatment of enterovirus infection with the use of pleconaril in 2 infants with severe combined immunodeficiency. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001, Volume: 32, Issue:1 Topics: Antiviral Agents; Enterovirus Infections; Feces; Female; Humans; Infant; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; RNA, Viral; Severe Combined Immunodeficiency	2001
Pleconaril: a novel antipicornaviral drug. Expert opinion on investigational drugs, 2001, Volume: 10, Issue:2 Topics: Antiviral Agents; Clinical Trials as Topic; Enterovirus Infections; Humans; Oxadiazoles; Oxazoles	2001
Treatment of ALS with pleconaril. Neurology, 2001, Mar-13, Volume: 56, Issue:5 Topics: Aged; Amyotrophic Lateral Sclerosis; Humans; Male; Oxadiazoles; Oxazoles	2001
Severe neonatal enteroviral hepatitis treated with pleconaril. The Pediatric infectious disease journal, 2001, Volume: 20, Issue:4 Topics: Antiviral Agents; Echovirus Infections; Enterovirus B, Human; Hepatitis, Viral, Human; Humans; Infant, Newborn; Liver Failure; Oxadiazoles; Oxazoles	2001
Acute flaccid paralysis syndrome associated with echovirus 19, managed with pleconaril and intravenous immunoglobulin. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2001, Sep-01, Volume: 33, Issue:5 Topics: Adult; Antiviral Agents; Echovirus Infections; Female; Humans; Immunocompromised Host; Immunoglobulins, Intravenous; Kidney Transplantation; Lung Transplantation; Oxadiazoles; Oxazoles; Paraplegia	2001
Design, synthesis, and structure-activity relationship of pyridyl imidazolidinones: a novel class of potent and selective human enterovirus 71 inhibitors. Journal of medicinal chemistry, 2002, Apr-11, Volume: 45, Issue:8 Topics: Animals; Antiviral Agents; Cell Line; Chlorocebus aethiops; Enterovirus; Humans; Imidazoles; Neutralization Tests; Oxadiazoles; Oxazoles; Pyridines; Structure-Activity Relationship; Viral Plaque Assay	2002
Synthesis and characterization of radioiodinated MD-230254: a new ligand for potential imaging of monoamine oxidase B activity by single photon emission computed tomography. Chemical & pharmaceutical bulletin, 2002, Volume: 50, Issue:5 Topics: Animals; In Vitro Techniques; Kinetics; Liver; Male; Mice; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxadiazoles; Oxazoles; Radiopharmaceuticals; Rats; Tissue Distribution; Tomography, Emission-Computed, Single-Photon	2002
FDA panel rejects common cold treatment. The Lancet. Infectious diseases, 2002, Volume: 2, Issue:5 Topics: Antiviral Agents; Common Cold; Drug Approval; Female; Humans; Oxadiazoles; Oxazoles; United States; United States Food and Drug Administration	2002
Cold comfort. The Lancet. Infectious diseases, 2002, Volume: 2, Issue:7 Topics: Antiviral Agents; Common Cold; Drug Approval; Humans; Oxadiazoles; Oxazoles; United States; United States Food and Drug Administration	2002
SPECT scans for monitoring response to pleconaril therapy in chronic enteroviral meningoencephalitis. The Journal of infection, 2003, Volume: 46, Issue:2 Topics: Adolescent; Adult; Antiviral Agents; Common Variable Immunodeficiency; Enterovirus; Enterovirus Infections; Female; HIV Infections; Humans; Immunocompromised Host; Male; Meningoencephalitis; Oxadiazoles; Oxazoles; Tomography, Emission-Computed, Single-Photon	2003
Survival after pulmonary edema due to enterovirus 71 encephalitis. Neurology, 2003, May-27, Volume: 60, Issue:10 Topics: Acute Disease; Antiviral Agents; Child, Preschool; Combined Modality Therapy; Disease Outbreaks; Encephalitis, Viral; Enterovirus; Enterovirus Infections; Female; Follow-Up Studies; Humans; Immunoglobulins, Intravenous; Infant; Magnetic Resonance Imaging; Male; New South Wales; Oxadiazoles; Oxazoles; Pulmonary Edema; Survival Analysis; Survivors	2003
Neurogenic pulmonary edema in enterovirus 71 encephalitis is not uniformly fatal but causes severe morbidity in survivors. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2003, Volume: 4, Issue:3 Topics: Antiviral Agents; Child, Preschool; Echocardiography; Encephalitis, Viral; Enterovirus; Enterovirus Infections; Female; Follow-Up Studies; Humans; Infant; Intensive Care Units, Pediatric; Magnetic Resonance Imaging; Male; Oxadiazoles; Oxazoles; Pulmonary Edema; Respiration, Artificial; Time Factors	2003
EFFECT ON CATALASE IN VIVO AND IN VITRO OF COMPOUNDS RELATED TO AMINOTRIAZOLE. ANL-6823. ANL, 1964 Topics: Amitrole; Azides; Azoles; Catalase; Enzyme Inhibitors; Erythrocytes; Imidazoles; In Vitro Techniques; Isoniazid; Kidney; Liver; Oxadiazoles; Oxazoles; Oxidation-Reduction; Pentylenetetrazole; Pharmacology; Pyrazoles; Rats; Research; Thiazoles; Triazoles	1964
[REACTIVITY OF DICARBONYL-ISOXAZOLES. VI. TRANSFORMATION OF 3-CARBONYL-ISOXAZOLE OXIMES INTO FURAZAN DERIVATIVES]. La Ricerca scientifica. 2. ser., pt. 2: Rendiconti. Sezione B: Biologica, 1964, Volume: 5 Topics: Chemistry, Pharmaceutical; Isoxazoles; Oxadiazoles; Oxazoles; Oximes; Pharmacy; Research	1964
[THERAPEUTIC VALUE OF OXOLAMINE CITRATE IN PEDIATRICS. A NEW ANTI-INFLAMMATORY SUBSTANCE]. Gazette medicale de France, 1964, Dec-10, Volume: 71 Topics: Anti-Inflammatory Agents; Biomedical Research; Child; Drug Therapy; Humans; Infant; Inflammation; Oxadiazoles; Oxazoles; Pediatrics; Toxicology	1964
Human rhinovirus capsid dynamics is controlled by canyon flexibility. Virology, 2003, Sep-15, Volume: 314, Issue:1 Topics: Antibodies, Viral; Antigen-Antibody Reactions; Binding Sites; Capsid; HeLa Cells; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Microscopy, Electron; Models, Molecular; Mutation; Oxadiazoles; Oxazoles; Rhinovirus; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Virus Assembly	2003
Safety and efficacy evaluation of pleconaril for treatment of the common cold. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2003, Dec-15, Volume: 37, Issue:12 Topics: Adult; Antiviral Agents; Common Cold; Controlled Clinical Trials as Topic; Drug Resistance, Viral; Evaluation Studies as Topic; Humans; Oxadiazoles; Oxazoles; Picornaviridae Infections	2003
Neonatal coxsackie B virus infection-a treatable disease? European journal of pediatrics, 2004, Volume: 163, Issue:4-5 Topics: Antiviral Agents; Cardiomyopathies; Coxsackievirus Infections; Disseminated Intravascular Coagulation; Enterovirus B, Human; Hepatitis; Humans; Infant; Infant, Newborn; Infant, Premature; Infectious Disease Transmission, Vertical; Meningoencephalitis; Oxadiazoles; Oxazoles; Perinatal Care; Polymerase Chain Reaction; Thrombocytopenia	2004
VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds. Journal of virology, 2004, Volume: 78, Issue:7 Topics: Amino Acid Sequence; Antiviral Agents; Binding Sites; Capsid; Drug Resistance, Viral; HeLa Cells; Humans; Models, Molecular; Molecular Sequence Data; Neutralization Tests; Oxadiazoles; Oxazoles; Phylogeny; Rhinovirus; Viral Proteins	2004
Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds. Journal of virology, 2004, Volume: 78, Issue:20 Topics: Antiviral Agents; Binding Sites; Crystallization; HeLa Cells; Humans; Models, Molecular; Oxadiazoles; Oxazoles; Rhinovirus; Virus Assembly; Virus Replication; X-Ray Diffraction	2004
Peroxynitrite-induced relaxation in isolated rat aortic rings and mechanisms of action. Toxicology and applied pharmacology, 2005, Dec-15, Volume: 209, Issue:3 Topics: Animals; Aorta; Calcium Chloride; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; In Vitro Techniques; Male; Marine Toxins; Methylene Blue; Oxadiazoles; Oxazoles; Peroxynitrous Acid; Phenylephrine; Piperazines; Potassium; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasodilation	2005
Susceptibility of coxsackievirus B3 laboratory strains and clinical isolates to the capsid function inhibitor pleconaril: antiviral studies with virus chimeras demonstrate the crucial role of amino acid 1092 in treatment. The Journal of antimicrobial chemotherapy, 2005, Volume: 56, Issue:4 Topics: Amino Acid Substitution; Animals; Antiviral Agents; Capsid; Capsid Proteins; Cell Line; CHO Cells; Cricetinae; Dose-Response Relationship, Drug; Drug Resistance, Viral; Enterovirus B, Human; Enterovirus Infections; Humans; Hydrophobic and Hydrophilic Interactions; Oxadiazoles; Oxazoles; Polymorphism, Genetic	2005
Insights into the genetic basis for natural phenotypic resistance of human rhinoviruses to pleconaril. Antiviral research, 2005, Volume: 68, Issue:3 Topics: Antiviral Agents; Capsid Proteins; Drug Resistance, Viral; Humans; Oxadiazoles; Oxazoles; Rhinovirus	2005
Duration of pleconaril effect on cytochrome P450 3A activity in healthy adults using the oral biomarker midazolam. Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:5 Topics: Adult; Antiviral Agents; Area Under Curve; Cytochrome P-450 CYP3A; Enzyme Induction; Female; Half-Life; Humans; Hypnotics and Sedatives; Intestines; Liver; Male; Midazolam; Middle Aged; Oxadiazoles; Oxazoles	2006
Investigation of treatment failure in neonatal echovirus 7 infection. The Pediatric infectious disease journal, 2006, Volume: 25, Issue:3 Topics: Antiviral Agents; Enterovirus B, Human; Enterovirus Infections; Fatal Outcome; Female; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases; Molecular Sequence Data; Oxadiazoles; Oxazoles; Sequence Analysis, DNA; Treatment Failure	2006
Antiviral treatment of Coxsackie B virus infection in human pancreatic islets. Antiviral research, 2007, Volume: 74, Issue:1 Topics: Antiviral Agents; Cells, Cultured; Coxsackievirus Infections; Cytopathogenic Effect, Viral; Diabetes Mellitus, Type 1; Enterovirus B, Human; Humans; Insulin; Islets of Langerhans; Oxadiazoles; Oxazoles	2007
Synthesis and biological evaluation of alkenyldiarylmethane HIV-1 non-nucleoside reverse transcriptase inhibitors that possess increased hydrolytic stability. Journal of medicinal chemistry, 2007, Oct-04, Volume: 50, Issue:20 Topics: Alkenes; Animals; Anti-HIV Agents; Benzoates; Cytopathogenic Effect, Viral; Drug Resistance, Viral; HIV Reverse Transcriptase; HIV-1; Hydrolysis; Mutation; Nitriles; Oxadiazoles; Oxazoles; Rats; Reverse Transcriptase Inhibitors; Stereoisomerism; Structure-Activity Relationship; Tetrazoles	2007
Acetic acid aldose reductase inhibitors bearing a five-membered heterocyclic core with potent topical activity in a visual impairment rat model. Journal of medicinal chemistry, 2008, Jun-12, Volume: 51, Issue:11 Topics: Acetates; Administration, Topical; Aldehyde Reductase; Animals; Binding Sites; Cataract; Galactosemias; Models, Molecular; Ophthalmic Solutions; Oxadiazoles; Oxazoles; Protein Binding; Protein Conformation; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship	2008
Optimization of azoles as anti-human immunodeficiency virus agents guided by free-energy calculations. Journal of the American Chemical Society, 2008, Jul-23, Volume: 130, Issue:29 Topics: Azoles; HIV Reverse Transcriptase; HIV-1; Models, Molecular; Monte Carlo Method; Mutation; Oxadiazoles; Oxazoles; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Thermodynamics	2008
New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3. Antiviral research, 2009, Volume: 81, Issue:1 Topics: Antiviral Agents; Drug Design; Drug Resistance, Viral; Enterovirus B, Human; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Mutation; Oxadiazoles; Oxazoles	2009
Theoretical analysis of solvent effects on nitrogen NMR chemical shifts in oxazoles and oxadiazoles. Journal of magnetic resonance (San Diego, Calif. : 1997), 2009, Volume: 197, Issue:2 Topics: Hydrogen Bonding; Magnetic Resonance Spectroscopy; Models, Chemical; Nitrogen; Oxadiazoles; Oxazoles; Quantum Theory; Solvents	2009
Design, synthesis, and biological activities of novel 2-cyanoacrylates containing oxazole, oxadiazole, or quinoline moieties. Journal of agricultural and food chemistry, 2009, Apr-08, Volume: 57, Issue:7 Topics: Amaranthus; Brassica napus; Digitaria; Drug Design; Enbucrilate; Herbicides; Magnetic Resonance Spectroscopy; Medicago sativa; Oxadiazoles; Oxazoles; Photosystem II Protein Complex; Plant Growth Regulators; Quinolines	2009
Antiviral treatments reduce severity of diabetes in Ljungan virus-infected CD-1 mice and delay onset in diabetes-prone BB rats. Microbiology and immunology, 2009, Volume: 53, Issue:10 Topics: Animals; Antibodies, Viral; Antiviral Agents; Diabetes Mellitus, Type 1; Drug Therapy, Combination; Humans; Immunologic Factors; Mice; Oxadiazoles; Oxazoles; Parechovirus; Picornaviridae Infections; Rats; Rats, Inbred BB; Ribavirin	2009
Induction of caspase-independent apoptotic-like cell death of mouse mammary tumor TA3Ha cells in vitro and reduction of their lethality in vivo by the novel chemotherapeutic agent GIT-27NO. Free radical biology & medicine, 2010, Apr-15, Volume: 48, Issue:8 Topics: Acetates; Animals; Caspase 3; Caspase 8; Caspase 9; Caspases; Cell Death; Cell Line, Tumor; Cell Survival; Down-Regulation; Female; Mammary Neoplasms, Experimental; Mice; Nitric Oxide; Oxadiazoles; Oxazoles; Peritoneal Neoplasms; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53	2010
Anti-human rhinovirus activity of raoulic acid from Raoulia australis. Journal of medicinal food, 2010, Volume: 13, Issue:2 Topics: Antiviral Agents; Asteraceae; Common Cold; Humans; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Phytotherapy; Picornaviridae Infections; Plant Extracts; Rhinovirus; Ribavirin; Terpenes; Virus Internalization	2010
Imaging dopamine D3 receptors in the human brain with positron emission tomography, [11C]PHNO, and a selective D3 receptor antagonist. Biological psychiatry, 2010, Aug-15, Volume: 68, Issue:4 Topics: Adult; Azabicyclo Compounds; Binding, Competitive; Brain; Brain Mapping; Carbon Radioisotopes; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Humans; Oxadiazoles; Oxazines; Oxazoles; Positron-Emission Tomography; Receptors, Dopamine D3; Tissue Distribution	2010
Curing the common cold. Scientific American, 2011, Volume: 304, Issue:1 Topics: Antiviral Agents; Common Cold; Humans; Influenza A Virus, H1N1 Subtype; Influenza, Human; Oxadiazoles; Oxazoles; Rhinovirus; Viral Structural Proteins; Viral Vaccines	2011
A fundamental role for NO-PLC signaling pathway in mediating intracellular Ca2+ oscillation in pancreatic acini. Nitric oxide : biology and chemistry, 2011, Apr-30, Volume: 24, Issue:3 Topics: Animals; Calcium; Carcinoma, Acinar Cell; Estrenes; Inositol 1,4,5-Trisphosphate; Macrocyclic Compounds; Male; Nitric Oxide; Nitric Oxide Donors; Nitroprusside; Oxadiazoles; Oxazoles; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Pyrrolidinones; Quinoxalines; Rats; Rats, Wistar; Signal Transduction; Sincalide; Type C Phospholipases	2011
A metal-free route to 2-aminooxazoles by taking advantage of the unique ring opening of benzoxazoles and oxadiazoles with secondary amines. Chemistry (Weinheim an der Bergstrasse, Germany), 2011, Jul-18, Volume: 17, Issue:30 Topics: Amines; Molecular Structure; Oxadiazoles; Oxazoles	2011
Pleconaril-resistant chronic parechovirus-associated enteropathy in agammaglobulinaemia. Antiviral therapy, 2011, Volume: 16, Issue:4 Topics: Adolescent; Agammaglobulinemia; Antiviral Agents; Caliciviridae Infections; Chronic Disease; Drug Resistance, Viral; Feces; Humans; Immunocompromised Host; Male; Norovirus; Oxadiazoles; Oxazoles; Parechovirus; Picornaviridae Infections; Protein-Losing Enteropathies	2011
Design, synthesis, biological evaluation and molecular modeling of 1,3,4-oxadiazoline analogs of combretastatin-A4 as novel antitubulin agents. Bioorganic & medicinal chemistry, 2012, Jan-15, Volume: 20, Issue:2 Topics: Antineoplastic Agents; Binding Sites; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Computer Simulation; Drug Design; Drug Screening Assays, Antitumor; Humans; Hydrogen Bonding; Naphthalenes; Oxadiazoles; Oxazoles; Protein Binding; Protein Structure, Tertiary; Stilbenes; Tubulin; Tubulin Modulators	2012
In vitro and in vivo evaluation of ribavirin and pleconaril antiviral activity against enterovirus 71 infection. Archives of virology, 2012, Volume: 157, Issue:4 Topics: Animals; Animals, Newborn; Antiviral Agents; Cell Line, Tumor; Cell Survival; Child, Preschool; Disease Models, Animal; Enterovirus A, Human; Enterovirus Infections; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Ribavirin; Survival Analysis	2012
Pleconaril revisited: clinical course of chronic enteroviral meningoencephalitis after treatment correlates with in vitro susceptibility. Antiviral therapy, 2012, Volume: 17, Issue:3 Topics: Antiviral Agents; Cerebrospinal Fluid; Child; Chronic Disease; Drug Resistance, Viral; Enterovirus; Enterovirus Infections; Female; Humans; Immunoglobulins, Intravenous; Male; Meningoencephalitis; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Polymerase Chain Reaction; Treatment Outcome	2012
In-Silico screening of Pleconaril and its novel substituted derivatives with Neuraminidase of H1N1 Influenza strain. BMC research notes, 2012, Feb-17, Volume: 5 Topics: Amino Acids; Antiviral Agents; Binding Sites; Biocatalysis; Catalytic Domain; Drug Evaluation, Preclinical; Drug Resistance, Viral; Enzyme Inhibitors; Humans; Hydrogen Bonding; Influenza A Virus, H1N1 Subtype; Influenza, Human; Models, Molecular; Molecular Structure; Neuraminidase; Oseltamivir; Oxadiazoles; Oxazoles; Protein Binding; Protein Structure, Tertiary	2012
Regioselective synthesis of 2-amino-substituted 1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives via reagent-based cyclization of thiosemicarbazide intermediate. The Journal of organic chemistry, 2013, Jan-18, Volume: 78, Issue:2 Topics: Cyclization; Indicators and Reagents; Magnetic Resonance Spectroscopy; Molecular Structure; Oxadiazoles; Oxazoles; Semicarbazides; Stereoisomerism; Thiadiazoles	2013
Synthesis and antifungal activity of 3-(1,3,4-oxadiazol-5-yl)-indoles and 3-(1,3,4-oxadiazol-5-yl)methyl-indoles. European journal of medicinal chemistry, 2013, Volume: 63 Topics: Antifungal Agents; Fungi; Indoles; Microbial Sensitivity Tests; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Structure-Activity Relationship	2013
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:3 Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication	2014
Genetic and antigenic structural characterization for resistance of echovirus 11 to pleconaril in an immunocompromised patient. The Journal of general virology, 2015, Volume: 96, Issue:Pt 3 Topics: Antigens, Viral; Antiviral Agents; Drug Resistance, Viral; Echovirus Infections; Enterovirus B, Human; Gene Expression Regulation, Viral; Humans; Immunoglobulins, Intravenous; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxadiazoles; Oxazoles	2015
ΔF508-CFTR correctors: synthesis and evaluation of thiazole-tethered imidazolones, oxazoles, oxadiazoles, and thiadiazoles. Bioorganic & medicinal chemistry letters, 2014, Dec-15, Volume: 24, Issue:24 Topics: Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Humans; Imidazoles; Kinetics; Molecular Conformation; Oxadiazoles; Oxazoles; Protein Binding; Structure-Activity Relationship; Thermodynamics; Thiadiazoles; Thiazoles; Water	2014
Structure and inhibition of EV-D68, a virus that causes respiratory illness in children. Science (New York, N.Y.), 2015, Jan-02, Volume: 347, Issue:6217 Topics: Antiviral Agents; Capsid; Child; Crystallography, X-Ray; Enterovirus D, Human; Enterovirus Infections; Humans; Hydrophobic and Hydrophilic Interactions; Oxadiazoles; Oxazoles; Respiratory Tract Diseases; United States; Viral Proteins	2015
Exploration of the anti-enterovirus activity of a series of pleconaril/pirodavir-like compounds. Antiviral chemistry & chemotherapy, 2015, Volume: 24, Issue:2 Topics: Antiviral Agents; Dose-Response Relationship, Drug; Enterovirus; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Piperidines; Pyridazines; Structure-Activity Relationship	2015
Phenoxymethyl 1,3-oxazoles and 1,2,4-oxadiazoles as potent and selective agonists of free fatty acid receptor 1 (GPR40). Bioorganic & medicinal chemistry letters, 2015, Aug-15, Volume: 25, Issue:16 Topics: Animals; Binding Sites; Caco-2 Cells; Cytochrome P-450 Enzyme System; Half-Life; Humans; Methylamines; Mice; Molecular Docking Simulation; Oxadiazoles; Oxazoles; Propionates; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Structure-Activity Relationship	2015
In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses. Virology journal, 2015, Jul-14, Volume: 12 Topics: Antiviral Agents; Capsid Proteins; Humans; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Piperidines; Protein Binding; Pyridazines; Rhinovirus	2015
Effect of consecutive alternating administration (CAA) of a triple anti-enteroviral combination on Coxsackievirus B1 neuroinfection in mice. Antiviral research, 2015, Volume: 121 Topics: Animals; Antiviral Agents; Apomorphine; Brain; Central Nervous System Infections; Coxsackievirus Infections; Disease Models, Animal; Drug Resistance, Viral; Drug Therapy, Combination; Enterovirus B, Human; Guanidine; Mice, Inbred ICR; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Survival Analysis; Treatment Outcome	2015
Antiviral Activity of Broad-Spectrum and Enterovirus-Specific Inhibitors against Clinical Isolates of Enterovirus D68. Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:12 Topics: Antiviral Agents; Drug Resistance, Viral; Enterovirus D, Human; Enterovirus Infections; Humans; Microbial Sensitivity Tests; Models, Molecular; Oxadiazoles; Oxazoles; Receptors, Drug; Respiratory Tract Infections; Viral Proteins; Virus Replication	2015
Molecular mechanism of a specific capsid binder resistance caused by mutations outside the binding pocket. Antiviral research, 2015, Volume: 123 Topics: Amino Acid Substitution; Antiviral Agents; Binding Sites; Capsid Proteins; DNA Mutational Analysis; Drug Resistance, Viral; Enterovirus B, Human; HeLa Cells; Humans; Microbial Sensitivity Tests; Models, Molecular; Molecular Dynamics Simulation; Mutation, Missense; Oxadiazoles; Oxazoles; Protein Binding; Protein Conformation; Virus Replication	2015
Hydrophobic pocket targeting probes for enteroviruses. Nanoscale, 2015, Nov-07, Volume: 7, Issue:41 Topics: Cell Line, Tumor; Coxsackievirus Infections; Enterovirus B, Human; Fluorescent Dyes; Gold; Humans; Hydrophobic and Hydrophilic Interactions; Oxadiazoles; Oxazoles	2015
SAR evolution and discovery of benzenesulfonyl matrinanes as a novel class of potential coxsakievirus inhibitors. Future medicinal chemistry, 2016, Volume: 8, Issue:5 Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Chlorocebus aethiops; Coxsackievirus Infections; Drug Discovery; Drug Resistance, Viral; Enterovirus; Humans; Isoquinolines; Male; Mice; Oxadiazoles; Oxazoles; RNA, Viral; Serine Endopeptidases; Structure-Activity Relationship; Sulfonamides; Vero Cells; Viral Proteins	2016
Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds. Antiviral research, 2016, Volume: 131 Topics: A549 Cells; Antimetabolites; Antiviral Agents; Benzimidazoles; Enterovirus A, Human; Enterovirus D, Human; Guanine; HeLa Cells; Humans; Oxadiazoles; Oxazoles; Oximes; Picornaviridae; Piperazines; Piperidines; Pyridazines; Rhabdomyosarcoma; Rhinovirus; Ribavirin; Sulfonamides	2016
Anti-enteroviral triple combination of viral replication inhibitors: activity against coxsackievirus B1 neuroinfection in mice. Antiviral chemistry & chemotherapy, 2015, Volume: 24, Issue:5-6 Topics: Animals; Antiviral Agents; Apomorphine; Cells, Cultured; Coxsackievirus Infections; Drug Resistance, Viral; Drug Therapy, Combination; Enterovirus B, Human; Humans; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Nitriles; Oxadiazoles; Oxazoles; Virus Replication	2015
Exploring Strategies for Labeling Viruses with Gold Nanoclusters through Non-equilibrium Molecular Dynamics Simulations. Bioconjugate chemistry, 2017, 09-20, Volume: 28, Issue:9 Topics: Antiviral Agents; Binding Sites; Capsid; Enterovirus; Gold; Hydrophobic and Hydrophilic Interactions; Ligands; Metal Nanoparticles; Molecular Dynamics Simulation; Oxadiazoles; Oxazoles; Palmitic Acid; Thermodynamics	2017
New class of early-stage enterovirus inhibitors with a novel mechanism of action. Antiviral research, 2017, Volume: 147 Topics: Antiviral Agents; Capsid; Capsid Proteins; Cell Line; Cytopathogenic Effect, Viral; Drug Resistance, Viral; Drug Synergism; Enterovirus B, Human; Enterovirus Infections; Genotype; Humans; Molecular Conformation; Molecular Docking Simulation; Oxadiazoles; Oxazoles; para-Aminobenzoates; Protein Binding; RNA, Viral; Structure-Activity Relationship; Virus Replication	2017
Chronic meningoencephalitis caused by Echo virus 6 in a patient with common variable immunodeficiency : Successful treatment with pleconaril. Wiener klinische Wochenschrift, 2018, Volume: 130, Issue:1-2 Topics: Adult; Common Variable Immunodeficiency; Echovirus 6, Human; Echovirus Infections; Humans; Male; Meningoencephalitis; Oxadiazoles; Oxazoles; Treatment Outcome	2018
Automated cell-based luminescence assay for profiling antiviral compound activity against enteroviruses. Scientific reports, 2019, 04-15, Volume: 9, Issue:1 Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Enterovirus; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Luminescent Measurements; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Valine; Vero Cells	2019
Cryo-EM structure of pleconaril-resistant rhinovirus-B5 complexed to the antiviral OBR-5-340 reveals unexpected binding site. Proceedings of the National Academy of Sciences of the United States of America, 2019, 09-17, Volume: 116, Issue:38 Topics: Antiviral Agents; Binding Sites; Capsid; Cryoelectron Microscopy; Drug Resistance, Viral; HeLa Cells; Humans; Models, Molecular; Molecular Structure; Oxadiazoles; Oxazoles; Picornaviridae Infections; Protein Binding; Protein Conformation; Rhinovirus; Structure-Activity Relationship; Viral Proteins	2019
A preclinical assessment to repurpose drugs to target type 1 diabetes-associated type B coxsackieviruses. Diabetic medicine : a journal of the British Diabetic Association, 2020, Volume: 37, Issue:11 Topics: A549 Cells; Amides; Antiviral Agents; Azithromycin; Benzimidazoles; Coxsackievirus Infections; Diabetes Mellitus, Type 1; Drug Repositioning; Enterovirus B, Human; Fluoxetine; Guanidine; Humans; Immunoglobulin G; Lovastatin; Oxadiazoles; Oxazoles; Oximes; Pyrazines; Ribavirin; Sulfonamides	2020
Novel pleconaril derivatives: Influence of substituents in the isoxazole and phenyl rings on the antiviral activity against enteroviruses. European journal of medicinal chemistry, 2020, Feb-15, Volume: 188 Topics: Animals; Antiviral Agents; Cell Survival; Dose-Response Relationship, Drug; Enterovirus; HeLa Cells; Humans; Male; Mice; Mice, Inbred BALB C; Microbial Sensitivity Tests; Molecular Structure; Oxadiazoles; Oxazoles; Structure-Activity Relationship	2020
Diversity-oriented synthesis and antifungal activities of novel pimprinine derivative bearing a 1,3,4-oxadiazole-5-thioether moiety. Molecular diversity, 2021, Volume: 25, Issue:1 Topics: Antifungal Agents; Biological Products; Indoles; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Pythium; Structure-Activity Relationship; Sulfides	2021
The Evolution of Pleconaril: Modified Molecules (Basel, Switzerland), 2020, Mar-16, Volume: 25, Issue:6 Topics: Animals; Antiviral Agents; Cell Death; Chlorocebus aethiops; Dogs; Enterovirus B, Human; Madin Darby Canine Kidney Cells; Oxadiazoles; Oxazoles; Piperazines; Vero Cells	2020
Effectiveness of Antivirals in a Type 1 Diabetes Model and the Move Toward Human Trials. Viral immunology, 2020, Volume: 33, Issue:9 Topics: Adult; Alkynes; Animals; Antiviral Agents; Benzoxazines; Cyclopropanes; Diabetes Mellitus, Type 1; Humans; Male; Oxadiazoles; Oxazoles; Proof of Concept Study; Rats; Ribavirin	2020
Effect of Consecutive Alternating Administration of a Triple Combination of Anti-Enteroviral Compounds in Mice Infected with Coxsackievirus B3. Pathogens and disease, 2020, 11-23, Volume: 78, Issue:9 Topics: Animals; Antiviral Agents; Apomorphine; Cell Line; Coxsackievirus Infections; Disease Models, Animal; Drug Resistance, Viral; Drug Synergism; Drug Therapy, Combination; Enterovirus B, Human; Humans; Mice; Nitriles; Oxadiazoles; Oxazoles; Virus Replication	2020
Structure of Human Enterovirus 70 and Its Inhibition by Capsid-Binding Compounds. Journal of virology, 2022, 09-14, Volume: 96, Issue:17 Topics: Antiviral Agents; Capsid; Capsid Proteins; Conjunctivitis, Acute Hemorrhagic; Cryoelectron Microscopy; Enterovirus D, Human; Humans; Oxadiazoles; Oxazoles; Virion	2022
Hierarchical Clustering and Target-Independent QSAR for Antileishmanial Oxazole and Oxadiazole Derivatives. International journal of molecular sciences, 2022, Aug-10, Volume: 23, Issue:16 Topics: Antiprotozoal Agents; Cluster Analysis; Humans; Leishmaniasis, Visceral; Oxadiazoles; Oxazoles; Quantitative Structure-Activity Relationship	2022