oxazoles has been researched along with okadaic acid in 361 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.28) | 18.7374 |
| 1990's | 227 (62.88) | 18.2507 |
| 2000's | 108 (29.92) | 29.6817 |
| 2010's | 24 (6.65) | 24.3611 |
| 2020's | 1 (0.28) | 2.80 |
| Authors | Studies |
|---|---|
| Schäfer, C; Wagner, AC; Williams, JA | 1 |
| Badwey, JA; Ding, J | 2 |
| Ariyoshi, H; Kambayashi, J; Kang, J; Kawasaki, T; Mori, T; Murata, K; Sakon, M; Shiba, E; Yukawa, M | 1 |
| Cao, X; Guy, GR; Mahendran, R; Tan, YH | 1 |
| Lerea, KM | 1 |
| Broquet, P; Geoffroy, J; George, P; Louisot, P; Reboul, P | 1 |
| Kuo, JF; Sakurada, K; Zheng, B | 1 |
| Iguchi, A; Ishiguro, T; Miura, H; Nonogaki, K; Sakamoto, N; Tamagawa, T; Uemura, K | 1 |
| Armstrong, SC; Ganote, CE | 1 |
| Brautigan, DL; Eriksson, JE; Fujiki, H; Goldman, RD; Olmsted, J; Vallee, R | 1 |
| Keller, H; Kreienbühl, P; Niggli, V | 1 |
| Deguchi, K; Ito, M; Kobayashi, K; Kuno, T; Morita, K; Nagao, M; Nakano, T; Nishikawa, M; Shima, H; Tanaka, C | 1 |
| Chubb, CH; Fujiki, H; Giometti, C; Huberman, E; Kiguchi, K | 1 |
| Goad, DL; Meurer, EA; Petrou, CP; Tashjian, AH; Voelkel, EF | 1 |
| Barros, F; de la Peña, P; del Camino, D; Delgado, LM | 1 |
| Chen, ZH; Gopalakrishna, R; Gundimeda, U | 1 |
| Fujiki, H; Furuya, H; Matsunaga, S; Matsushima, R; Nishiwaki, S; Okabe, S; Suganuma, M; Sugimura, T; Yatsunami, J; Yoshizawa, S | 1 |
| Han, YG; Hartshorne, DJ; Hori, M; Karaki, H; Magae, J | 1 |
| Blondfield, DP; Fusetani, N; Ozaki, H; Publicover, NG; Sanders, KM; Uemura, D; Vogalis, F; Ward, SM | 1 |
| Carl, A; Fusetani, N; Kenyon, JL; Sanders, KM; Uemura, D | 1 |
| Fujiki, H; Nishiwaki, S; Suganuma, M; Sugimura, T; Winyar, B; Yoshizawa, S | 1 |
| Garrison, JC; Mattingly, RR | 1 |
| Cohen, P; Holmes, CF; Tsukitani, Y | 1 |
| Fujiki, H; Furuya-Suguri, H; Fusetani, N; Kato, Y; Suganuma, M; Sugimura, T; Yasumoto, S; Yoshizawa, S | 1 |
| Cohen, P | 1 |
| Fujiki, H; Nishiwaki, S; Schmitz, FJ; Suganuma, M; Sugimura, T; Winyar, B; Yoshizawa, S | 1 |
| Brautigan, DL; Fusetani, N; Hashimoto, K; Ishihara, H; Karaki, H; Kato, Y; Martin, BL; Ozaki, H; Uemura, D; Watabe, S | 1 |
| Bajpai, A; Brahmi, Z | 2 |
| Belandia, B; Cuadrado, MA; Delgado, MD; León, J; Lerga, A; Martín-Perez, J; Ortiz, JM; Richard, C | 1 |
| Arima, S; Inokoshi, J; Katagiri, M; Matsuzaki, K; Omura, S; Tanaka, H | 1 |
| Fontana, A; Groscurth, P; Malipiero, U; Weller, M | 1 |
| Fetz, I; Fölsch, UR; Höcker, M; Kern, HF; Meyer-Alber, A; Schmidt, WE; Waschulewski, IH | 1 |
| Glaum, SR; Miller, RJ | 1 |
| Fetz, I; Fölsch, UR; Höcker, M; Meyer-Alber, A; Schmidt, WE; Waschulewski, IH | 1 |
| García-Sáinz, JA; González-Espinosa, C | 1 |
| Bruder, JT; Geppert, TD; Owaki, H; Rapp, UR; Whitehurst, CE | 1 |
| Chik, CL; Ho, AK | 1 |
| Fetz, I; Fölsch, UR; Fornefeld, H; Höcker, M; Meyer-Alber, A; Schmidt, WE; Waschulewski, IH | 1 |
| Chik, CL; Ho, AK; Karpinski, E; Kovacs, CS; Li, B | 1 |
| Berg, T; Berg, TO; Brech, A; Fengsrud, M; Gordon, PB; Holen, I; Roos, N; Seglen, PO; Strømhaug, PE | 1 |
| Jordan, NJ; Watson, ML; Westwick, J | 1 |
| Bøe, R; Døskeland, SO; Gjertsen, BT; Vintermyr, OK | 1 |
| Huang, CY; Qin, K; Santini, F; Wang, Y | 1 |
| Del Castillo, JR; Sepúlveda, FV | 1 |
| Herzig, S; Meier, A; Neumann, J; Pfeiffer, M | 1 |
| Hoyt, CH; Lerea, KM | 1 |
| Harhaj, E; Maggirwar, SB; Sun, SC | 1 |
| Day, MA; Garcia, JG; Patterson, CE; Verin, AD | 1 |
| Hasegawa, H; Kurihara, K; Matsumoto, R; Minami, N; Nakanishi, N; Onozawa, S; Ueha, T | 1 |
| Carriger, ML; Malphurs, WL; Vickroy, TW | 1 |
| Marantz, Y; Naor, Z; Przedecki, F; Reiss, N | 1 |
| Chong, AS; Curry, MS; Edwards, BS; Graf, LH; Southon, EA | 1 |
| Haneji, T; Kobayashi, S; Murata, T; Shirakawa, S; Takehara, T | 1 |
| Elsner-Menzel, C; Frank, S; Menzel, D; Vugrek, O | 1 |
| Eyster, KM; Johnson, MJ; Miller, CJ; Miller, TL; Persing, JS; Waller, MS | 1 |
| Danenberg, K; Danenberg, PV; Lenz, HJ; Scavetta, R; Schönthal, AH; Wang, SJ | 1 |
| Cressey, LI; Døskeland, SO; Gjertsen, BT; Houge, G; Lanotte, M; Ruchaud, S | 1 |
| Combadière, C; Djerdjouri, B; Hakim, J; Pedruzzi, E; Périanin, A | 1 |
| Kambayashi, J; Kawasaki, T; Sakon, M; Senda, T; Shibata, N; Tanaka, K; Yamada, F; Yano, Y | 1 |
| Aggarwal, BB; Singh, S | 1 |
| Bouron, A; Reber, BF | 1 |
| Abayasekara, RE; Ford, SL; Jones, PM; Persaud, SJ | 1 |
| Papasozomenos, SC; Su, Y | 1 |
| Jochum, C; Mayer, P; Pfeiffer, A; Schatz, H | 1 |
| Assmann, SM; Li, W; Luan, S; Schreiber, SL | 1 |
| Borgese, F; Garcia-Romeu, F; Guizouarn, H; Motais, R; Pellissier, B | 1 |
| Cossins, AR; Ellory, JC; Gibson, JS; Godart, H; Honess, NA; Staines, H | 1 |
| Pshenichkin, SP; Wise, BC | 1 |
| Johnston, JA; Silver, RB; Sloboda, RD | 1 |
| Volz, A | 1 |
| Nicoll, RA; Wyllie, DJ | 1 |
| Kao, LS; Lin, LF; Westhead, EW | 1 |
| Kobryn, CE; Mandel, LJ | 1 |
| Koch, B; Lutz-Bucher, B | 1 |
| Cressey, LI; Døskeland, SO; Gjertsen, BT; Gliemann, J; Hokland, P; Jensen, PH; Lanotte, M; Madsen, P; Mellgren, G; Vintermyr, OK | 1 |
| Kleinhaus, AL; Zeman, RJ | 1 |
| Mizuno, M; Packer, L; Suzuki, YJ | 1 |
| Bokník, P; Herzig, S; Neumann, J; Schmitz, W; Scholz, H; Wiechen, K; Zimmermann, N | 1 |
| Alverez, J; Garcia-Sancho, J; Montero, M | 1 |
| Bai, G; Lee, EY; Long, F; Nagao, M; Shima, H; Zhang, L; Zhang, Z; Zhao, S | 1 |
| Deguchi, K; Kuno, T; Morita, K; Nagao, M; Nishikawa, M; Saito, M; Shima, H; Shirakawa, S; Tawara, I; Toyoda, H | 1 |
| Boynton, AL; Codispoti, BA; Honkanan, RE; Honkanen, RE; Tse, K | 1 |
| Koike, Y; Kume, S; Kurota, K; Ozaki, Y; Qi, R; Satoh, K; Yatomi, Y | 1 |
| Athlan, ES; Mushynski, WE; Sacher, MG | 1 |
| Giebisch, G; Hebert, SC; Ho, K; McNicholas, CM; Wang, W | 1 |
| Ashizawa, K; Nishinakama, K; Tomonaga, H; Tsuzuki, Y; Wishart, GJ | 1 |
| Bollen, M; De Smedt, H; Himpens, B | 1 |
| Chu, FS; Lin, JR | 1 |
| Chambers, TC; Kuo, JF; Raynor, RL | 1 |
| Bona, BJ; Moyer, ML; Nordeen, SK | 1 |
| Sakamoto, N; Shuntoh, H; Tanaka, C | 1 |
| Brautigan, DL; MacDonald, JF; Orser, BA; Wang, LY | 1 |
| Finbloom, DS; Luong, H; Winestock, KD | 1 |
| Mariash, CN; Sudo, Y | 1 |
| Berggren, PO; Honkanen, RE; Sjöholm, A | 1 |
| Ishibashi, S; Kuwana, M; Okamura, N; Sakai, M; Sasaki, J; Yamaguchi, M | 1 |
| Gali, RR; Khandelwal, RL; Pugazhenthi, S; Yu, B | 1 |
| Husøy, T; Mikalsen, SO; Sanner, T | 1 |
| Sheen, J | 1 |
| Larrick, JW; Torti, FM; Wright, SC; Zheng, H; Zhong, J | 1 |
| Iwata, M; Mukai, M; Nakai, Y; Ohoka, Y | 1 |
| Iwata, H; Nakanishi, H; Suganuma, M; Tatematsu, M; Yoshida, K; Yuasa, H | 1 |
| Favre, B; Hemmings, BA; Kiefer, B; Lee, JS; Nagamine, Y | 1 |
| Alvarez, J; García-Sancho, J; Montero, M | 1 |
| Endo, Y; Furuya, S; Nozawa, S; Oba, M; Osumi, K; Suzuki, S | 1 |
| Brenner, HR; Britt, JC; Caroni, P; Rotzler, S | 1 |
| Obara, K; Yabu, H | 1 |
| Bøe, R; Døskeland, SO; Mellgren, G; Vintermyr, OK | 1 |
| Chan, CK; Downey, GP; Grinstein, S; Takai, A; Zamel, R | 1 |
| Fujitani, K; Kambayashi, J; Kawasaki, T; Mori, T; Murata, K; Sakon, M; Shiba, E; Yano, Y; Yukawa, M | 1 |
| Gordon, PB; Holen, I; Seglen, PO | 1 |
| Elmslie, KS; Jones, SW; Overholt, JL; Werz, MA | 1 |
| Herron, CE; Malenka, RC; Mulkey, RM | 1 |
| Fujitani, K; Kambayashi, J; Kawasaki, T; Mori, T; Murata, K; Sakon, M; Shiba, E; Uemura, Y; Yano, Y | 1 |
| Kennelly, PJ; Oxenrider, KA; Rasche, ME; Thorsteinsson, MV | 1 |
| James, DE; Lawrence, JC; Robinson, LJ; Robinson, R | 1 |
| Gundersen, GG; Gurland, G | 1 |
| Klein, JD; O'Neill, WC; Perry, PB | 1 |
| da Cruz e Silva, EF; da Cruz e Silva, OA; Greengard, P; Zaia, CT | 1 |
| Chen, G; Gao, XM; Newell, SW; Perchellet, EM; Perchellet, JP | 1 |
| Azzi, A; Bartoli, GM; Boscoboinik, D; Maroni, P; Tasinato, A | 1 |
| Handschumacher, RE; Li, W | 1 |
| Wright, SC; Zheng, H; Zhong, J | 1 |
| Hernández, ML; López de Heredia, M; Martínez, MJ; Ochoa, B | 2 |
| Cronstein, BN; Landau, S; Montesinos, MC; Naime, D; Revan, S | 1 |
| Brown, MK; Eastman, A; Li, J; Morana, SJ; Reynolds, JE; Wolf, CM | 1 |
| Chock, PB; Huang, CY; Tekle, E; Zhu, DM | 1 |
| Comolli, J; Hastings, JW; Rehman, J; Taylor, W | 1 |
| Baum, L; Kawabata, S; Koyama, M; Maruyama, K; Saitoh, T; Seger, R; Silver, J; Woodgett, JR | 1 |
| Bragado, MJ; Duan, RD; Hwang, J; Williams, JA | 1 |
| Ambudkar, IS; Sakai, T | 1 |
| Nagao, T; Urushidani, T | 1 |
| Jennings, ML; Namboodiripad, AN | 1 |
| Collier, B; Gauthier, S; Issa, AM | 3 |
| Hedman, H; Lundgren, E | 1 |
| Patzlaff, JS; Paulson, JR; Vallis, AJ | 1 |
| Abe, H; Obinata, T; Okada, K; Takano-Ohmuro, H | 1 |
| Iuorno, J; Weeks, BS | 1 |
| Barbier, J; Begon, F; Kraimps, JL; Métayé, T; Sarrouilhe, D | 1 |
| da Cruz e Silva, EF; Greengard, P; Khatra, B; Smith, GD; Stephens, DT; Trautman, K; Vijayaraghavan, S | 1 |
| da Cruz e Silva, EF; Greengard, P; Smith, GD; Trautman, KC; Vijayaraghavan, S; Wolf, DP | 1 |
| Boudreaux, JM; Newberry, EP; Towler, DA | 1 |
| Abayasekara, DR; Ford, SL; Jones, PM; Persaud, SJ | 2 |
| Munday, MR; Peachell, PT; Peirce, MJ; Warner, JA | 1 |
| Marriott, I; Mason, MJ | 1 |
| Dales, S; Kalicharran, K; Mohandas, D; Wilson, G | 1 |
| Gilbert, LI; Song, Q | 1 |
| Ito, Y; Kozawa, O; Oiso, Y; Suzuki, A; Watanabe-Tomita, Y | 1 |
| Chueh, SH; Ho, MY; Hu, SY; Song, SL | 1 |
| Haneji, T; Kobayashi, S; Morimoto, Y; Ohba, T | 1 |
| Bagu, JR; Craig, MM; Holmes, CF; Sykes, BD | 1 |
| Grocholová, R; Jílek, F; Petr, J; Rozinek, J | 1 |
| Duclos, B; Durocher, Y; Grangeasse, C; Haftek, M; Schmitt, D; Serres, M | 1 |
| Sawai, T | 1 |
| Diaz, J; Kaji, DM; Parker, JC | 1 |
| Begg, AC; Coco-Martin, JM | 1 |
| Keller, H; Niggli, V | 1 |
| Favre, B; Hemmings, BA; Turowski, P | 1 |
| Diwan, AH; Honkanen, RE; Schaeffer, RC; Strada, SJ; Thompson, WJ | 1 |
| Cousin, JM; Haslett, C; Rossi, AG | 1 |
| Lee, VM; Merrick, SE; Trojanowski, JQ | 1 |
| Ang, KL; Antaraki, A; Antoni, FA | 1 |
| Marwitz, J; Opitz, R; Quentin, I; Ritz, V; Steinfelder, HJ; Tergau, F; von Zezschwitz, C; Weichert, J | 1 |
| Blaukat, A; Müller-Esterl, W | 1 |
| Pinna, C; Rossini, GP; Viviani, R | 1 |
| Amzil, Z; James, KJ; Marcaillou-Le Baut, C; Pouchus, YF; Verbist, JF | 1 |
| Lawrence, JC; Lin, TA | 1 |
| Ha, KS; Jung, HI; Kang, KW; Park, YM; Shin, I | 1 |
| Kwan, CY; Leung, YM; Loh, TT | 1 |
| Steinfelder, HJ; Tergau, F; von Zezschwitz, C; Vorwerk, H | 1 |
| Badwey, JA; Ding, J; Ellis, BA; Heyworth, PG; Robinson, JM | 1 |
| Kramer, RH; Molokanova, E; Savchenko, A; Trivedi, B | 1 |
| Elhanany, E; Hemi, R; Kanety, H; Karasik, A; LeRoith, D; Paz, K; Zick, Y | 1 |
| Jones, PM; Sayed, SB; Whitehouse, BJ | 1 |
| Armstrong, RW; Du, X; Gupta, V; Houk, KN; Ogawa, AK | 1 |
| Beachy, PA; Chen, CH; Krishnan, V; Pereira, FA; Qiu, Y; Tsai, MJ; Tsai, SY | 1 |
| bin He, Z; Li, J; Sekar, N; Shechter, Y | 1 |
| Briat, JF; Lobréaux, S; Savino, G | 1 |
| Clark, B; Leven, RM; Tablin, F | 1 |
| Detimary, P; Gilon, P; Henquin, JC; Mariot, P; Sato, Y | 1 |
| Chun, RF; Jeang, KT; Neuveut, C; Semmes, OJ | 1 |
| Sadhu, A; Smith, GD; Wolf, DP | 1 |
| Baumann, B; Bergman, Y; Kirillov, A; Kistler, B; Wirth, T | 1 |
| Cobb, RR; Qiu, W; Scholz, W | 1 |
| Cuisset, L; Delpech, M; Tichonicky, L | 1 |
| Gietzen, KF; Rivers, A; Vielhaber, E; Virshup, DM | 1 |
| Asao, N; Matsumura, T; Saito-Ito, A; Tanabe, K; Yamamoto, M; Yokoyama, D | 1 |
| Takai, A | 1 |
| Fujiki, H; Suganuma, M | 2 |
| Diener, M; Schultheiss, G | 1 |
| Aune, T; Døskeland, SO; Fladmark, KE; Larsen, NL; Serres, MH; Yasumoto, T | 1 |
| Cubillos, S; Lima, L | 1 |
| Förstermann, U; Fritz, G; Geller, DA; Ihrig-Biedert, I; Kleinert, H; Rodriguez-Pascual, F; Wallerath, T | 1 |
| Lazo, JS; Rice, RL; Settineri, CE; Vogt, A; Wipf, P; Yokokawa, F; Yokokawa, S | 1 |
| Fass, U; Huizar, I; Li, DW; Spector, A | 1 |
| Aperia, A; Caplan, MJ; Cheng, SX; Fisone, G; Li, D; Ohtomo, Y | 1 |
| Munday, MR; Peachell, PT; Peirce, MJ | 1 |
| Bochner, BS; Seminario, MC; Sterbinsky, SA | 1 |
| Andreeva, AV; Evans, DE; Kutuzov, MA | 1 |
| Ashizawa, K; Sakuragi, M; Tsuzuki, Y | 1 |
| Chik, CL; Ho, AK; Karpinski, E; Li, B | 1 |
| Fabre, S; Georget, V; Lobaccaro, JM; Lumbroso, S; Poujol, N; Sultan, C; Térouanne, B | 1 |
| Hatch, GM; Kelly, SL; Xu, FY | 1 |
| Bernards, R; Farlie, PG; Lam, EW; Voorhoeve, PM; Watson, RJ | 1 |
| Chang, M; Chen, X; Wang, B; Wu, R | 1 |
| Greengard, P; Nairn, AC; Nishi, A; Snyder, GL | 1 |
| Callahan, KS; Clikeman, JA; Hoidal, JR; Terry, CM | 1 |
| Buyukkececi, F; Omay, SB; Saydam, G; Terzioglu, E; Tobu, M; Uslu, R; Uzunoglu, S | 1 |
| Okuno, M; Si, Y | 1 |
| Degerman, E; Manganiello, V; Oknianska, A; Resjö, S; Zolnierowicz, S | 1 |
| Gill, DL; Patterson, RL; van Rossum, DB | 1 |
| Haneji, T; Kobayashi, S; Morimoto, H; Morimoto, Y; Ohba, T | 1 |
| Mumby, MC; Yan, Y | 1 |
| Condrescu, M; Fang, Y; Hantash, BM; Reeves, JP | 1 |
| Bize, I; Brugnara, C; Buchbinder, G; Güvenç, B; Robb, A | 1 |
| Inada, H; Inagaki, M; Kaibuchi, K; Nagata, K; Nakamura, Y; Togashi, H | 1 |
| Boe, R; Brustugun, OT; Døskeland, SO; Fladmark, KE; Gjertsen, BT; Hovland, R; Zhivotovsky, B | 1 |
| Glavy, JS; Orr, GA; Wang, PJ; Wolkoff, AW; Wu, SM | 1 |
| Aslan, DC; Lazo, JS; Luci, DK; Southwick, EC; Wipf, P | 1 |
| Nelson, S; Spitzer, JA; Summer, WR; Zhang, P | 1 |
| Fujita, M; Fukuda, J; Haneji, T; Kobayashi, S; Seta, C | 1 |
| Chen, KD; Chen, LY; Cho, JH; Lai, MT; Lai, YK | 1 |
| Bennett, M; Orr, GA; Takvorkan, P; Tanowitz, HB; Weiss, LM; Werner, C; Wittner, M; Xu, J | 1 |
| Becker, K; Brechlin, P; Krautheim, A; Steinfelder, HJ; Winkler, M | 1 |
| Alcántara-Hernández, R; Gárcia-Sáinz, JA; Vázquez-Prado, J | 1 |
| Holst, J; Ludowyke, RI; Mudge, LM; Sim, AT | 1 |
| Buxbaum, JD; Corfas, G; Peschon, JJ; Rio, C | 1 |
| Burns, CJ; Gyles, S; Jones, PM; Persaud, SJ; Sayed, SB; Whitehouse, BJ | 1 |
| Craig, RW; Domina, AM; Smith, JH | 1 |
| Alfonso, M; Arufe, MC; Beckett, GJ; Durán, R | 1 |
| Enomoto, R; Hiraoka, R; Ishikawa, E; Lee, E; Nakatsuma, A; Yamauchi, A | 1 |
| Inui, T; Ishizaki, T; Matsukawa, S; Miyamori, I; Saito, Y; Sasaki, F; Shiozaki, K; Yamamura, T | 1 |
| Bellon, G; Fawzi, A; Kefalides, NA; Monboisse, JC; Robinet, A; Ziaie, Z | 1 |
| Kamiya, A | 1 |
| Bibb, JA; Caporaso, GL; Fienberg, AA; Greengard, P; Hemmings, HC; Nairn, AC; Rakhilin, S; Snyder, GL; Valle, C | 1 |
| da Costa, SR; Hamm-Alvarez, SF; Runnegar, M; Yarber, FA; Zhang, L | 1 |
| Chaudhuri, S; Raha, S | 1 |
| Ludowyke, RI; Scurr, LL; Warton, K | 1 |
| Fusetani, N; Miyaji, K; Nakazawa, T; Tosuji, H | 1 |
| Jefferson, LS; Kimball, SR; Shah, OJ | 1 |
| Erdös, EG; Marcic, BM | 1 |
| Gamba, G; Mercado, A; Mount, DB; Song, L; Vazquez, N | 1 |
| Eguchi-Kasai, K; Hayata, I; Kanda, R | 1 |
| Dietrich, J; Geisler, C; Kastrup, J; Lauritsen, JP; Menné, C; Odum, N | 1 |
| Gohda, E; Nagao, T; Yamamoto, I | 1 |
| Apparsundaram, S; Bauman, AL; Blakely, RD; Ramamoorthy, S; Vaughan, RA; Wadzinski, BE | 1 |
| Khandelwal, RL; Syed, NA | 1 |
| Fujiki, Y; Ito, M; Nishida, I; Watanabe, A | 1 |
| Bennecib, M; Gong, CX; Grundke-Iqbal, I; Iqbal, K | 2 |
| Embrey, KJ; Pierens, GK; Quinn, RJ; Volter, KE | 1 |
| Beale, G; Cross, J; England, K; Rumsby, M; Warner, M; Watson, J | 1 |
| Bennett, PC; Ng, KT; Zhao, W | 1 |
| Allam, A; Illges, H | 1 |
| Dietrich, J; Geisler, C; Kastrup, J; Lauritsen, JP; Menné, C | 1 |
| Lai, MT; Vlahos, CJ; Zinda, MJ | 1 |
| Fujiwara, A; Kawamoto, M; Kuno, S; Yasumasu, I | 1 |
| Crook, RB; Layne, J; Yip, S | 1 |
| Rapp, M; Spessert, R; Vollrath, L | 1 |
| Enomoto, R; Koyamazaki, R; Lee, E; Maruta, Y; Mori, K; Takuma, K; Tanaka, M | 1 |
| Bastan, R; Peachell, PT; Peirce, MJ | 1 |
| Meraldi, P; Nigg, EA | 1 |
| Klein, JD; Sands, JM; Zhang, C | 1 |
| Cox, JV; Ghosh, S | 1 |
| Egger, T; Goti, D; Hammer, A; Malle, E; Sattler, W; Wintersperger, A | 1 |
| Chalfant, CE; Hannun, YA; Obeid, LM; Ogretmen, B; Pinkerman, RL; Rathman, K; Wood, RE | 1 |
| Chen, KC; Hsu, HL; Huang, HH; Kau, JH; Lin, CG; Lin, HC; Wu, YP | 1 |
| Hirasaki, S; Koide, N; Nakamura, M; Shinji, T; Tsuji, T; Ujike, K | 1 |
| Kurihara, K; Moore-Hoon, ML; Nakanishi, N; Turner, RJ | 1 |
| Kruse, ML; Roloff, T; Schmidt, WE; Seebeck, J; Tritschler, S; Ziegler, A | 1 |
| Knight, H; Knight, MR; Wright, AJ | 1 |
| Buerger, F; Cress, AE; Davis, TL | 1 |
| Furukawa, T; Inagaki, N; Katayama, Y; Nakaya, H; Ogura, T; Tsuchiya, H; Zheng, YJ | 1 |
| Garcia, F; Garcia, L; Gómez, N; Itarte, E; Llorens, F; Unzeta, M | 1 |
| Bertrand, L; Hue, L; Krause, U | 1 |
| Hamaguchi, Y; Kuriyama, R | 1 |
| Ramonell, K; Somerville, S; Stacey, G; Zhang, B | 1 |
| Al-Khalili, O; Becchetti, A; Duchatelle, P; Eaton, DC; Kleyman, TR; Malik, B; Yue, G | 1 |
| Blatt, MR; Köhler, B | 1 |
| Andrews, DA; Low, PS; Yang, L | 1 |
| Foissner, I; Grolig, F; Obermeyer, G | 1 |
| Abel, T; Nguyen, PV; Woo, NH | 1 |
| Bambino, T; Bencsik, M; Chauvin, S; Nissenson, RA | 1 |
| Greif, DM; Kou, R; Michel, T | 1 |
| Huwiler, A; Pfeilschifter, J; Ren, S; Rölz, W; Xin, C | 1 |
| Clark, S; Jones, KH; Kang-Park, MH; Moore, SD; Sarda, MA; Shenolikar, S; Wilson, WA | 1 |
| Fandrich, RR; Jeyaraman, M; Kardami, E; Lukas, A; Tanguy, S | 1 |
| Biglioli, P; Capogrossi, MC; Cicchillitti, L; Fasanaro, P; Martelli, F | 1 |
| Baeyens, JM; Cendán, CM; Del Pozo, E; Moncada, A | 1 |
| Göke, B; Groblewski, GE; Krzykowski, KJ; Schäfer, C; Steffen, H | 1 |
| Gyorke, I; Gyorke, S; Terentyev, D; Terentyeva, R; Viatchenko-Karpinski, S | 1 |
| Campbell, KS; Chang, D; Colbran, RJ; Kamoun, M; Kloeker, S; Law, BK; McConnell, JL; Reed, R; Tran, K; Wadzinski, BE; Westphal, RS | 1 |
| Black, JD; Leontieva, OV | 1 |
| Golden, TA; Honkanen, RE | 1 |
| duBell, WH; Rogers, TB | 1 |
| Bui, HT; Miyano, T; Yamaoka, E | 1 |
| Honkanen, RE; Lehtihet, M; Sjöholm, A | 1 |
| Maruyama-Nakashita, A; Nakamura, Y; Takahashi, H; Watanabe-Takahashi, A; Yamaya, T | 1 |
| Barrett, EF; Barrett, JN; Nonner, D; Panickar, K | 1 |
| Chatfield, K; Eastman, A | 1 |
| Blakely, WF; Prasanna, PG | 1 |
| Arora, A; Choe, ES; Fibuch, EE; Liu, Z; Mao, L; Wang, JQ; Yang, L; Zhang, G | 1 |
| Boon, A; Bridges, D; Deadwyler, SA; Grigorenko, E; Hampson, RE; McCloud, S; Zhuang, SY | 1 |
| Adragna, NC; Lauf, PK; Zhang, J | 1 |
| Chung, J; Pang, P; Simpkins, JW; Yi, KD | 1 |
| Buck, LT; Pamenter, ME; Shin, DS; Wilkie, MP | 1 |
| Chen, CS; Lin, HP; Tseng, PH; Weng, SC | 1 |
| Hatano, N; Kume, K; Song, T; Sugimoto, K; Tokuda, M; Watanabe, Y; Yamaguchi, F | 1 |
| Evans, NE; Forth, MK; Mason, MJ; Simpson, AK | 1 |
| McKeown-Longo, PJ; Zheng, M | 1 |
| Deng, M; Feng, H; Gong, L; Li, DW; Liu, JP; Liu, WB; Liu, Y; Schlosser, R; Schmid, PC; Sun, SM; Yan, Q | 1 |
| He, J; Jiang, H; Pu, S; Tang, C; Tansey, JT; Xu, G | 1 |
| Guan, X; Nakauchi, S; Sumikawa, K | 1 |
| Arora, A; Fibuch, EE; Kingston, S; Mao, L; Wang, JQ; Yang, L | 1 |
| Ashizawa, K; Katayama, S; Narumi, K; Ranasinghe, AR; Takano, D; Tsuzuki, Y; Wishart, GJ | 1 |
| Agalakova, NI; Gusev, GP; Ivanova, TI | 1 |
| Brautigan, DL; Prickett, TD | 1 |
| Barrett, KE; Chow, JY | 1 |
| Brautigan, DL; Ding, J; Smith, GD; Swain, JE; Villa-Moruzzi, E | 1 |
| Honkanen, RE; Ni, L; Swingle, M | 1 |
| Inoue, M; Kubota, M; Mino, M; Nogi, T; Zhang, S | 1 |
| Harrison, RA; Jebe, E; Petrunkina, AM; Töpfer-Petersen, E; Tsolova, M | 1 |
| Chang, YC; Jin, JO; Kim, JW; Kwak, JY; Lee, JS; Park, HY; Park, JI; Song, MG | 1 |
| Brush, M; Shenolikar, S; Sikes, S; Steplock, D; Voltz, JW; Weinman, EJ | 1 |
| Boon-Unge, K; Govitrapong, P; Yu, Q; Zhou, A; Zhou, J; Zou, T | 1 |
| Geballe, AP; Hakki, M | 1 |
| Bernhard, EJ; Grawenda, AM; Hamilton, J | 1 |
| Chen, CH; Chen, GH; Huang, SJ; Lee, CY; Li, SY; Lin, MJ; Su, MC; Su, TR; Yang, JJ | 1 |
| Ayon, R; Forrest, AS; Greenwood, IA; Leblanc, N; Perrino, BA; Sanguinetti, AR; Sones, W; Valencik, ML; Wiwchar, M | 1 |
| Dynia, DW; Kocinsky, HS; Steinmetz, AG | 1 |
| Arcelay, E; Krapf, D; Pilder, SH; Salicioni, AM; Sanjay, A; Visconti, PE; Wertheimer, EV | 1 |
| Bausen, M; Betz, H; O'Sullivan, GA; Weltzien, F | 1 |
| Chathoth, S; Galadari, S; Hago, A; Kizhakkayil, J; Patel, M; Shahin, A; Thayyullathil, F | 1 |
| Amyotte, N; Chik, CL; Ho, AK; Kanyo, R; McTague, J | 1 |
| Doll, C; Pöll, F; Schulz, S | 1 |
| Brough, D; Giles, JA; Lopez-Castejon, G; Luheshi, NM | 1 |
| Farràs, R; Ferragud, J; Ferrero, M; Font de Mora, J; Orlando, L; Sánchez del Pino, M; Valero, L | 1 |
| Hayashi, K; Kinoshita, T; Takahashi, K | 1 |
| Balogh, E; Bátori, R; Csernoch, L; Dienes, B; Erdődi, F; Gáll, T; Lontay, B; Nagy, G; Oláh, T; Ruzsnavszky, O; Vincze, J | 1 |
| Chen, L; Chen, S; Chen, X; Du, Q; Han, W; Li, Y; Olumi, AF; Qian, X; Ruan, A; Wang, R; Wang, X; Yang, H; Zhang, X | 1 |
| Gray, EE; Guglietta, R; Khakh, BS; O'Dell, TJ | 1 |
| Craig, RW; Kasof, G; Nifoussi, SK; Ornstein, DL; Ratcliffe, NR; Strack, S | 1 |
| Ahammad, RU; Amano, M; Hamaguchi, T; Kaibuchi, K; Nakamuta, S; Nishioka, T; Shohag, MH; Yura, Y | 1 |
| Atmaca, H; Bozkurt, E; Erdogan, AP; Gursoy, P; Karaca, B; Şanlı, UA; Sezgin, C; Surmeli, Z; Uslu, R; Uzunoglu, S | 1 |
| Døskeland, SO; Herfindal, L; Kleppe, R | 1 |
| Foss, KM; Kornbluth, S; Robeson, AC; Zhang, L | 1 |
| Attieh, R; Dbaibo, G; El-Hed, AF; Hage-Sleiman, R; Hamze, AB; Kabbani, S; Kozhaya, L | 1 |
| Abe, M; Goto, T; Hagiwara, M; Hosoya, T; Ikura, T; Ito, N; Kato-Sumida, T; Kii, I; Koike, Y; Nonaka, Y; Okuno, Y; Shibuya, H; Sonamoto, R; Sumida, Y; Yoshida, S | 1 |
| B K, S; Bhat, NN; Desai, U; K Chaurasia, R; Nairy, RK; Shirsath, K; Yadav, U; Yerol, N | 1 |
| Britt, WJ; Djinović-Carugo, K; Hartl, M; Kastner, MT; Majdic, O; Puchinger, MG; Rieder, FJJ; Schneider, M; Steininger, C | 1 |
| Chen, Y; Cheng, YC; Hsieh, CH; Hueng, DY; Tsai, WC | 1 |
| Chen, F; Gong, CX; Gu, J; Hu, W; Iqbal, K; Liu, F; Miao, S; Wang, W; Wu, F | 1 |
| Just, S; Köhler, D; Pott, A; Pylatiuk, C; Rottbauer, W; Shahid, M; Weinmann, K | 1 |
| Balaban, PM; Maltsev, AV | 1 |
7 review(s) available for oxazoles and okadaic acid
| Article | Year |
|---|---|
Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway.
Topics: Animals; Antifungal Agents; Carcinogens; Ethers, Cyclic; Liver Neoplasms; Marine Toxins; Mice; Molecular Structure; Okadaic Acid; Oxazoles; Peptides, Cyclic; Pyrans; Rats; Skin Neoplasms; Spiro Compounds; Stomach Neoplasms; Structure-Activity Relationship | 1992 |
Okadaic acid: a new probe for the study of cellular regulation.
Topics: Animals; Carcinogens; Cell Extracts; Cells; Diarrhea; Ethers, Cyclic; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Shellfish Poisoning | 1990 |
The structure and regulation of protein phosphatases.
Topics: Animals; DNA; Enzyme Activation; Ethers, Cyclic; Fungal Proteins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Processing, Post-Translational; Second Messenger Systems; Structure-Activity Relationship; Subcellular Fractions | 1990 |
[Naturally occurring toxins with specific inhibitory activity against protein serine/threonine phosphatases 1 and 2A].
Topics: Alkenes; Animals; Antifungal Agents; Cantharidin; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Polyenes; Pyrans; Pyrones; Spiro Compounds | 1998 |
[Tumor promotion by inhibitors of protein phosphatase 1 and 2A].
Topics: Animals; Antifungal Agents; Marine Toxins; Microcystins; Neoplasms, Experimental; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 1; Pyrans; Spiro Compounds | 1998 |
Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors.
Topics: Animals; Carcinogens; Disease Progression; Enzyme Inhibitors; Humans; Marine Toxins; Mice; Models, Molecular; Neoplasms; Neoplasms, Experimental; Okadaic Acid; Oxazoles; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2009 |
Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.
Topics: Animals; Apoptosis; Carcinogens; Cell Death; Enzyme Inhibitors; Humans; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Reactive Oxygen Species | 2015 |
354 other study(ies) available for oxazoles and okadaic acid
| Article | Year |
|---|---|
Effects of calyculin A on amylase release in streptolysin-O permeabilized acinar cells.
Topics: Amylases; Animals; Bacterial Proteins; Calcium; Carcinogens; Cell Membrane Permeability; Dose-Response Relationship, Drug; Ethers, Cyclic; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Rats; Rats, Sprague-Dawley; Streptolysins; Tetradecanoylphorbol Acetate | 1992 |
Effects of antagonists of protein phosphatases on superoxide release by neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Calcium; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Guinea Pigs; Isoquinolines; Magnesium; Marine Toxins; Models, Biological; Neutrophils; Okadaic Acid; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Piperazines; Superoxides; Tetradecanoylphorbol Acetate | 1992 |
The effects of okadaic acid and calyculin A on thrombin induced platelet reaction.
Topics: Adenosine Triphosphate; Blood Platelets; Calcium; Epoprostenol; Ethers, Cyclic; Humans; In Vitro Techniques; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Phosphatase 1; Thrombin | 1992 |
Protein phosphatase inhibitors induce the sustained expression of the Egr-1 gene and the hyperphosphorylation of its gene product.
Topics: 3T3 Cells; Animals; Base Sequence; Blood; Blotting, Northern; Blotting, Western; Cells, Cultured; DNA; DNA-Binding Proteins; Early Growth Response Protein 1; Ethers, Cyclic; Gene Expression Regulation; Humans; Immediate-Early Proteins; Kinetics; Marine Toxins; Mice; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Transcription Factors | 1992 |
Inhibitors of protein phosphatase type 1 and 2A attenuate phosphatidylinositol metabolism and Ca(2+)-transients in human platelets. Role of a cdc2-related protein kinase.
Topics: Blood Platelets; Calcium; CDC2 Protein Kinase; Electrophoresis, Gel, Two-Dimensional; Ethers, Cyclic; Humans; In Vitro Techniques; Marine Toxins; Okadaic Acid; Oxazoles; Peptide Mapping; Phosphatidylinositols; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Secretory Rate; Serotonin; Thrombin | 1992 |
Study of O-glycan sialylation in C6 cultured glioma cells: regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by Ca2+/calmodulin antagonists and phosphatase inhibitors.
Topics: Animals; beta-Galactoside alpha-2,3-Sialyltransferase; Calmodulin; Carbohydrate Sequence; Ethers, Cyclic; Glioma; Glycosylation; Homeostasis; Imidazoles; Kinetics; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Sialyltransferases; Sulfonamides; Tumor Cells, Cultured | 1992 |
Comparative effects of protein phosphatase inhibitors (okadaic acid and calyculin A) on human leukemia HL60, HL60/ADR and K562 cells.
Topics: Cell Death; Cell Division; Ethers, Cyclic; Humans; Leukemia; Marine Toxins; Mitosis; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Tumor Cells, Cultured | 1992 |
Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on insulin release from rat pancreatic islets.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Ethers, Cyclic; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Potassium; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1992 |
Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on metabolically inhibited and ischaemic isolated myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Ethers, Cyclic; Heart; In Vitro Techniques; Marine Toxins; Myocardial Contraction; Myocardial Ischemia; Myocardium; Okadaic Acid; Osmotic Fragility; Oxazoles; Phosphoprotein Phosphatases; Rats | 1992 |
Cytoskeletal integrity in interphase cells requires protein phosphatase activity.
Topics: Animals; Cell Line; Cricetinae; Cytoskeleton; Ethers, Cyclic; Interphase; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Peptide Mapping; Phosphopeptides; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinases; Pyrans; Vimentin | 1992 |
Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils.
Topics: Actins; Cytoskeleton; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Edetic Acid; Ethers, Cyclic; Humans; In Vitro Techniques; Kinetics; Marine Toxins; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Pinocytosis; Tetradecanoylphorbol Acetate | 1992 |
Augmentation of retinoic acid-induced granulocytic differentiation in HL-60 leukemia cells by serine/threonine protein phosphatase inhibitors.
Topics: Cell Adhesion; Cell Differentiation; Chromatography, Agarose; Ethers, Cyclic; Granulocytes; Humans; Leukemia; Macrophages; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1992 |
Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A.
Topics: Antibodies, Monoclonal; Autoradiography; Blotting, Northern; Breast Neoplasms; Caseins; Cell Differentiation; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Female; Fluorescent Antibody Technique; Gene Expression; Genes, fos; Genes, jun; Humans; Isoenzymes; Kinetics; Marine Toxins; Microcystins; Okadaic Acid; Oligonucleotide Probes; Oxazoles; Peptides, Cyclic; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Pyrans; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Protein phosphatase inhibitors and bone resorption: inhibition by okadaic acid and biphasic actions of calyculin-A.
Topics: Animals; Animals, Newborn; Autoradiography; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Cyclic AMP; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Kinetics; Marine Toxins; Mice; Mice, Inbred Strains; Okadaic Acid; Organ Culture Techniques; Oxazoles; Parathyroid Hormone; Peptide Fragments; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorus Radioisotopes; Protein Biosynthesis; Protein Phosphatase 1; RNA; Teriparatide; Tetradecanoylphorbol Acetate | 1992 |
Okadaic acid and calyculin A enhance the effect of thyrotropin-releasing hormone on GH3 rat anterior pituitary cells excitability.
Topics: Action Potentials; Animals; Cells, Cultured; Ethers, Cyclic; Ionophores; Marine Toxins; Microelectrodes; Okadaic Acid; Oscillometry; Oxazoles; Pituitary Gland, Anterior; Rats; Thyrotropin-Releasing Hormone | 1992 |
Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C.
Topics: Animals; Carcinogens; Cell Line; Cell Membrane; Cytosol; Ethers, Cyclic; Immunoblotting; Kidney; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1992 |
A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle.
Topics: Animals; Antifungal Agents; Aorta; Calcium; Enzyme Inhibitors; Ethers, Cyclic; Guinea Pigs; Kinetics; Macromolecular Substances; Marine Toxins; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Myosins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pyrans; Rabbits; Rats; Spiro Compounds; Verapamil | 1991 |
Inhibition of electrical slow waves and Ca2+ currents of gastric and colonic smooth muscle by phosphatase inhibitors.
Topics: Animals; Calcium Channels; Colon; Dogs; Electrophysiology; Ethers, Cyclic; Female; Gastric Mucosa; In Vitro Techniques; Male; Marine Toxins; Muscle, Smooth; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Stomach | 1991 |
Regulation of Ca(2+)-activated K+ channels by protein kinase A and phosphatase inhibitors.
Topics: Animals; Calcium; Dogs; Ethers, Cyclic; Female; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Potassium Channels; Protein Kinases | 1991 |
Mechanisms of action of okadaic acid class tumor promoters on mouse skin.
Topics: Animals; Carcinogens; DNA; DNA Damage; DNA, Neoplasm; Enzyme Activation; Ethers, Cyclic; Genes, ras; Humans; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Proteins; Pyrans; Receptors, Drug; Skin; Skin Neoplasms; Structure-Activity Relationship | 1991 |
Okadaic acid inhibits angiotensin II stimulation of Ins(1,4,5)P3 and calcium signalling in rat hepatocytes.
Topics: Angiotensin II; Animals; Calcium; Ethers, Cyclic; Inositol 1,4,5-Trisphosphate; Ionophores; Liver; Marine Toxins; Okadaic Acid; Oxazoles; Rats; Signal Transduction | 1992 |
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Binding Sites; Ethers, Cyclic; Female; Marine Toxins; Mice; Mice, Inbred Strains; Molecular Weight; Nuclear Proteins; Nucleolin; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; RNA-Binding Proteins; Skin; Skin Neoplasms | 1990 |
A new pathway of tumor promotion by the okadaic acid class compounds.
Topics: Animals; Binding, Competitive; Brain; Carcinogens; Cytosol; DNA, Neoplasm; Ethers, Cyclic; Humans; Marine Toxins; Mice; Molecular Structure; Mutation; Nuclear Proteins; Nucleolin; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Protein Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Pyrans; Receptors, Drug; RNA-Binding Proteins; Skin; Skin Neoplasms; Spiro Compounds; Structure-Activity Relationship | 1990 |
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
Topics: Alkaline Phosphatase; Animals; Cattle; Chickens; Ethers, Cyclic; Female; Humans; Kinetics; Macromolecular Substances; Marine Toxins; Myosins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Placenta; Pregnancy; Vasoconstrictor Agents | 1989 |
Regulation of human natural killer-cell lytic activity by serine/threonine phosphatases and kinases.
Topics: Cell Line; Cytotoxicity, Immunologic; Enzyme Inhibitors; Ethers, Cyclic; Homeostasis; Humans; Killer Cells, Natural; Kinetics; Lymphoma; Marine Toxins; Okadaic Acid; Oxazoles; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Thymus Neoplasms; Tumor Cells, Cultured | 1995 |
Down-regulation of c-Myc and Max genes is associated to inhibition of protein phosphatase 2A in K562 human leukemia cells.
Topics: Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; Blotting, Northern; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers, Cyclic; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Marine Toxins; Okadaic Acid; Oxazoles; Protein Biosynthesis; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-myc; RNA, Messenger; Time Factors; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Neuronal differentiation of Neuro 2a cells by lactacystin and its partial inhibition by the protein phosphatase inhibitors calyculin A and okadaic acid.
Topics: Acetylcholinesterase; Acetylcysteine; Animals; Antifungal Agents; Biomarkers; Bucladesine; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Ethers, Cyclic; Hydroquinones; Kinetics; Marine Toxins; Neurites; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Pyrans; Spiro Compounds; Time Factors | 1995 |
T cell apoptosis induced by interleukin-2 deprivation or transforming growth factor-beta 2: modulation by the phosphatase inhibitors okadaic acid and calyculin A.
Topics: Animals; Apoptosis; Cell Division; Cell Line; Cell Membrane; DNA Damage; Endoplasmic Reticulum, Rough; Enzyme Inhibitors; Ethers, Cyclic; Gene Expression Regulation; Interleukin-2; Marine Toxins; Mice; Nucleosomes; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; RNA, Messenger; T-Lymphocytes; Transforming Growth Factor beta | 1995 |
Serine/threonine phosphatases play a role in stimulus-secretion coupling in pancreatic acinar cells.
Topics: Amylases; Animals; Culture Techniques; Cyclosporine; Dose-Response Relationship, Drug; Ethers, Cyclic; Male; Marine Toxins; Microscopy, Electron; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Secretory Rate; Signal Transduction; Threonine | 1994 |
Inhibition of phosphoprotein phosphatases blocks metabotropic glutamate receptor effects in the rat nucleus tractus solitarii.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Ethers, Cyclic; In Vitro Techniques; Marine Toxins; Membrane Potentials; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Receptors, Metabotropic Glutamate; Solitary Nucleus; Tacrolimus | 1994 |
Calyculin A, okadaic acid and W-7 interfere with a distal step in pancreatic acinar signal transduction.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amylases; Animals; Calcium; Cyclic AMP; Ethers, Cyclic; Inositol 1,4,5-Trisphosphate; Male; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Rats; Rats, Wistar; Secretory Rate; Signal Transduction; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vasoactive Intestinal Peptide | 1994 |
Protein kinases and phosphatases modulate c-fos expression in rat hepatocytes. Effects of angiotensin II and phorbol myristate acetate.
Topics: Alkaloids; Angiotensin II; Animals; Ethers, Cyclic; Female; Gene Expression; Genes, fos; Genistein; Isoflavones; Marine Toxins; Microcystins; Naphthalenes; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Binding Sites; Cell Line; Enzyme Activation; Epitopes; Ethers, Cyclic; Hemagglutinins; Humans; MAP Kinase Kinase Kinase 1; Marine Toxins; Mice; Molecular Sequence Data; Okadaic Acid; Oligopeptides; Oxazoles; Phosphoprotein Phosphatases; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Receptor-CD3 Complex, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Phosphatase inhibitors potentiate adrenergic-stimulated cAMP and cGMP production in rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antifungal Agents; Cyclic AMP; Cyclic GMP; Drug Synergism; Ethers, Cyclic; Isoproterenol; Kinetics; Male; Marine Toxins; Norepinephrine; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pineal Gland; Protein Phosphatase 2; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds | 1995 |
Differential inhibitory effects of serine/threonine phosphatase inhibitors and a calmodulin antagonist on phosphoinositol/calcium- and cyclic adenosine monophosphate-mediated pancreatic amylase secretion.
Topics: Amylases; Animals; Calcium; Calmodulin; Cyclic AMP; Cyclosporine; Ethers, Cyclic; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Rats, Wistar; Signal Transduction; Sulfonamides | 1995 |
Inhibition of serine/threonine protein phosphatases enhances agonist-stimulated cAMP accumulation in UMR 106 osteoblast-like cells.
Topics: 1-Methyl-3-isobutylxanthine; Antifungal Agents; Colforsin; Cyclic AMP; Dinoprostone; Ethers, Cyclic; Humans; Kinetics; Marine Toxins; Okadaic Acid; Osteoblasts; Oxazoles; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Protein Serine-Threonine Kinases; Proteins; Pyrans; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors.
Topics: Animals; Asialoglycoproteins; Cell Fractionation; Cellobiose; Centrifugation, Density Gradient; Endocytosis; Enzyme Inhibitors; Ethers, Cyclic; Genistein; Iodine Radioisotopes; Isoflavones; Liver; Male; Marine Toxins; Microcystins; Okadaic Acid; Orosomucoid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Rats; Rats, Wistar; Tyramine; Vacuoles | 1995 |
The protein phosphatase inhibitor calyculin A stimulates chemokine production by human synovial cells.
Topics: Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Cytokines; Enzyme Inhibitors; Ethers, Cyclic; Fibroblasts; Gene Expression; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; RNA, Messenger; Synovial Membrane; Tumor Necrosis Factor-alpha | 1995 |
8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Adenosine Deaminase; Amino Acid Sequence; Apoptosis; Biotransformation; Breast Neoplasms; Chromatin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Damage; Ethers, Cyclic; Female; Humans; Marine Toxins; Microvilli; Molecular Sequence Data; Necrosis; Okadaic Acid; Organelles; Oxazoles; Phosphoprotein Phosphatases | 1995 |
A Mg(2+)-dependent, Ca(2+)-inhibitable serine/threonine protein phosphatase from bovine brain.
Topics: Amino Acid Sequence; Animals; Brain; Calcium; Cations; Cattle; Enzyme Inhibitors; Ethers, Cyclic; Magnesium; Marine Toxins; Mice; Molecular Sequence Data; Molecular Weight; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylase a; Phosphorylase Kinase; Protein Conformation; Protein Phosphatase 2; Protein Phosphatase 2C; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 1995 |
Activation of an Na+/K+/2Cl- cotransport system by phosphorylation in crypt cells isolated from guinea pig distal colon.
Topics: Animals; Bumetanide; Calcium; Chlorides; Colon; Ethers, Cyclic; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Ionomycin; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Protein Kinases; Sodium | 1995 |
Stimulation of protein phosphatases as a mechanism of the muscarinic-receptor-mediated inhibition of cardiac L-type Ca2+ channels.
Topics: Acetylcholine; Animals; Calcium Channels; Chick Embryo; Dose-Response Relationship, Drug; Ethers, Cyclic; Female; Isoproterenol; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Receptors, Muscarinic; Time Factors | 1995 |
Aggregation-dependent signaling in human platelets is sensitive to protein serine/threonine phosphatase inhibitors.
Topics: Blood Platelets; Cytoskeletal Proteins; Ethers, Cyclic; Humans; Kinetics; Marine Toxins; Membrane Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Signal Transduction; Thrombin | 1995 |
Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.
Topics: Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Drug Synergism; Enzyme Inhibitors; Ethers, Cyclic; Humans; I-kappa B Proteins; Leupeptins; Marine Toxins; Multienzyme Complexes; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Phosphatase 2; Protein Processing, Post-Translational; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Regulation of endothelial cell gap formation and barrier function by myosin-associated phosphatase activities.
Topics: Animals; Blotting, Western; Capillary Permeability; Cattle; Cells, Cultured; Endothelium, Vascular; Ethers, Cyclic; Gap Junctions; Marine Toxins; Myosins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Rabbits; Tissue Distribution | 1995 |
Effects of protein kinase inhibitors and protein phosphatase inhibitors on cyclic AMP-dependent down-regulation of vesicular monoamine transport in pheochromocytoma PC12 cells.
Topics: Animals; Biogenic Monoamines; Biological Transport; Bucladesine; Carbazoles; Cyclic AMP; Down-Regulation; Ethers, Cyclic; Glycoproteins; Indole Alkaloids; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Norepinephrine; Okadaic Acid; Oxazoles; PC12 Cells; Pheochromocytoma; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Rats; Serotonin; Vesicular Biogenic Amine Transport Proteins | 1995 |
Regulation of stimulus-dependent hippocampal acetylcholine release by okadaic acid-sensitive phosphoprotein phosphatases.
Topics: Acetylcholine; Animals; Ethers, Cyclic; Hippocampus; Male; Marine Toxins; Models, Biological; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Synaptosomes; Vanadates | 1995 |
Involvement of protein phosphatases in gonadotropin releasing hormone regulated gonadotropin secretion.
Topics: Animals; Cells, Cultured; Enzyme Activation; Ethers, Cyclic; Female; Gonadotropin-Releasing Hormone; Ionomycin; Luteinizing Hormone; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Gland; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1995 |
Evidence for a dithiol-activated signaling pathway in natural killer cell avidity regulation of leukocyte function antigen-1: structural requirements and relationship to phorbol ester- and CD16-triggered pathways.
Topics: Actins; Animals; Cations, Divalent; Cell Adhesion; Cytoskeleton; Dithiothreitol; Ethers, Cyclic; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Killer Cells, Natural; Lymphocyte Function-Associated Antigen-1; Marine Toxins; Membrane Proteins; Mice; Naphthalenes; Neoplasm Proteins; Okadaic Acid; Oxazoles; Oxidation-Reduction; Phosphoprotein Phosphatases; Phosphorylation; Protein Conformation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, IgG; Signal Transduction; Structure-Activity Relationship; Sulfhydryl Reagents; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Protein phosphatase inhibitors, okadaic acid and calyculin A, induce alkaline phosphatase activity in osteoblastic cells derived from newborn mouse calvaria.
Topics: Alkaline Phosphatase; Amino Acids; Animals; Animals, Newborn; Clone Cells; Enzyme Induction; Enzyme Stability; Ethers, Cyclic; Marine Toxins; Mice; Okadaic Acid; Osteoblasts; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Phosphorylation; Skull; Temperature | 1995 |
Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia.
Topics: Acetabularia; Actins; Amino Acid Sequence; Chloroplasts; Cloning, Molecular; Cytoskeleton; DNA, Complementary; Ethers, Cyclic; Gene Expression Regulation, Developmental; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 1995 |
The endogenous inhibitor of protein kinase-C in the rat ovary is a protein phosphatase.
Topics: Animals; Brain; Cytosol; Ethers, Cyclic; Female; Histones; Marine Toxins; Microcystins; Myelin Basic Protein; Okadaic Acid; Ovary; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase C; Pseudopregnancy; Rats; Rats, Sprague-Dawley | 1993 |
Gene amplification and multidrug resistance induced by the phosphatase-inhibitory tumor promoter, okadaic acid.
Topics: 3T3 Cells; Animals; Carcinogens; Cell Division; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Ethers, Cyclic; Gene Amplification; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Verapamil | 1995 |
Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line.
Topics: Animals; Apoptosis; Cell Cycle; Cell Membrane; Cell Nucleus; Chromatin; Cyclic AMP; Cytoplasm; DNA Damage; Dose-Response Relationship, Drug; Ethers, Cyclic; Leukemia, Promyelocytic, Acute; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; RNA, Ribosomal, 28S; Signal Transduction; Tumor Cells, Cultured | 1994 |
Contrasting effects of calyculin A and okadaic acid on the respiratory burst of human neutrophils.
Topics: Amino Acid Sequence; Calcimycin; Ethers, Cyclic; Humans; In Vitro Techniques; Marine Toxins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Cytoskeletal reorganization of human platelets induced by the protein phosphatase 1/2 A inhibitors okadaic acid and calyculin A.
Topics: Actins; Adult; Antibodies; Blood Platelets; Cytoskeleton; Ethers, Cyclic; Humans; Marine Toxins; Microscopy, Confocal; Microscopy, Electron; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Phosphatase 1; Tubulin | 1995 |
Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B.
Topics: Adenosine Triphosphate; Arsenicals; Base Sequence; Ceramides; Diamide; DNA-Binding Proteins; Dose-Response Relationship, Drug; Ethers, Cyclic; Humans; I-kappa B Proteins; In Vitro Techniques; Interleukin-1; Marine Toxins; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Oligodeoxyribonucleotides; Oxazoles; Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vanadates | 1995 |
Calyculin-A-induced fast neurite retraction in nerve growth factor-differentiated rat pheochromocytoma (PC12) cells.
Topics: Animals; Calcium; Cell Differentiation; Cytoskeleton; Ethers, Cyclic; Fura-2; Marine Toxins; Nerve Growth Factors; Neurites; Okadaic Acid; Oxazoles; PC12 Cells; Phosphoprotein Phosphatases; Rats | 1995 |
Phosphoprotein phosphatase activities in rat luteal cells.
Topics: Animals; Cantharidin; Corpus Luteum; Ethers, Cyclic; Female; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Superovulation | 1995 |
Rapid dephosphorylation of tau in heat-shocked fetal rat cerebral explants: prevention and hyperphosphorylation by inhibitors of protein phosphatases PP1 and PP2A.
Topics: Animals; Axons; Brain; Ethers, Cyclic; Female; Hot Temperature; Immunohistochemistry; In Vitro Techniques; Male; Marine Toxins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Shock; tau Proteins | 1995 |
Okadaic acid indicates a major function for protein phosphatases in stimulus-response coupling of RINm5F rat insulinoma cells.
Topics: Animals; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Ethers, Cyclic; Insulin; Insulinoma; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Tumor Cells, Cultured | 1994 |
Evidence for protein phosphatase 1 and 2A regulation of K+ channels in two types of leaf cells.
Topics: Adenosine Triphosphate; Egtazic Acid; Ethers, Cyclic; Fabaceae; Homeostasis; Kinetics; Marine Toxins; Membrane Potentials; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Plant Leaves; Plants, Medicinal; Potassium Channels; Protein Phosphatase 1 | 1994 |
Regulation of Na+/H+ exchange activity by recruitment of new Na+/H+ antiporters: effect of calyculin A.
Topics: Acids; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Ethers, Cyclic; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Sodium-Hydrogen Exchangers; Temperature; Trout | 1995 |
Modulation of K(+)-Cl- cotransport in equine red blood cells.
Topics: Animals; Carboxylic Acids; Carrier Proteins; Chlorides; Dose-Response Relationship, Drug; Erythrocytes; Ethers, Cyclic; Female; Homeostasis; Horses; Hydrogen-Ion Concentration; Indenes; K Cl- Cotransporters; Magnesium; Male; Marine Toxins; Okadaic Acid; Oxazoles; Oxygen; Phosphates; Phosphoprotein Phosphatases; Potassium; Potassium Channels; Rubidium; Symporters | 1994 |
Okadaic acid increases nerve growth factor secretion, mRNA stability, and gene transcription in primary cultures of cortical astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Cell Nucleus; Cells, Cultured; Cerebral Cortex; DNA Probes; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ethers, Cyclic; Gene Expression; Genes, fos; Genes, jun; Kinetics; Marine Toxins; Nerve Growth Factors; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1995 |
Phosphoprotein phosphatase 1 (PP1) is a component of the isolated sea urchin mitotic apparatus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Ethers, Cyclic; Female; Marine Toxins; Microtubule-Associated Proteins; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Processing, Post-Translational; Sea Urchins; Spindle Apparatus | 1994 |
Regulation of CD18 expression in human neutrophils as related to shape changes.
Topics: Amino Acid Sequence; Antigens, CD; CD18 Antigens; Cell Movement; Cell Size; Chemotactic Factors; Ethers, Cyclic; Humans; In Vitro Techniques; Indoles; Marine Toxins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oligopeptides; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Leukocyte-Adhesion; Tetradecanoylphorbol Acetate | 1993 |
A role for protein kinases and phosphatases in the Ca(2+)-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electrophysiology; Ethers, Cyclic; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Protein Kinases; Receptors, AMPA; Synapses | 1994 |
Agents that promote protein phosphorylation inhibit the activity of the Na+/Ca2+ exchanger and prolong Ca2+ transients in bovine chromaffin cells.
Topics: Animals; Bucladesine; Calcium; Carrier Proteins; Cattle; Chromaffin System; Drug Synergism; Ethers, Cyclic; Fura-2; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Sodium-Calcium Exchanger | 1994 |
Decreased protein phosphorylation induced by anoxia in proximal renal tubules.
Topics: Alkaloids; Animals; Benzophenanthridines; Ethers, Cyclic; Hypoxia; In Vitro Techniques; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Marine Toxins; Okadaic Acid; Oxazoles; Phenanthridines; Phosphates; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Proteins; Rabbits; Reference Values | 1994 |
Inhibition of protein phosphatases by okadaic acid and calyculin-A differentially modulates hormonal- and forskolin-stimulated formation of cyclic AMP in AtT-20 corticotrophs: effect of pituitary adenylate activating polypeptide and corticotropin-releasin
Topics: Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Cell Line; Cells, Cultured; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Dose-Response Relationship, Drug; Ethers, Cyclic; Marine Toxins; Neuropeptides; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland, Anterior; Rats | 1994 |
Cleaved intracellular plasminogen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis.
Topics: Apoptosis; Biomarkers, Tumor; Bone Marrow; Cell Death; Ethers, Cyclic; Humans; Intracellular Fluid; Isomerism; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Plasminogen Activator Inhibitor 2; Tumor Cells, Cultured | 1994 |
Protein phosphatase inhibitors prolong Ca(2+)-transients and divalent cation-dependent action potentials in leech Retzius cells.
Topics: Action Potentials; Animals; Calcium; Cations, Divalent; Ethers, Cyclic; Fura-2; Ganglia, Invertebrate; Leeches; Marine Toxins; Membrane Potentials; Nerve Fibers; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Proteins | 1994 |
Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.
Topics: Antioxidants; Base Sequence; Cell Line; Ethers, Cyclic; Humans; Marine Toxins; Molecular Sequence Data; NF-kappa B; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Reactive Oxygen Species; RNA, Messenger; Signal Transduction | 1994 |
Biochemical and electrophysiological mechanisms of the positive inotropic effect of calyculin A, a protein phosphatase inhibitor.
Topics: Animals; Calcium Channels; Calcium-Binding Proteins; Ethers, Cyclic; Guinea Pigs; In Vitro Techniques; Marine Toxins; Myocardial Contraction; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Stimulation, Chemical | 1994 |
Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors.
Topics: Alkaloids; Calcium; Down-Regulation; Ethers, Cyclic; Humans; Indoles; Leukotriene B4; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine | 1994 |
A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity.
Topics: Amino Acid Sequence; Animals; DNA Primers; Ethers, Cyclic; Kinetics; Marine Toxins; Microcystins; Molecular Sequence Data; Mutagenesis, Site-Directed; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Rabbits; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
Calyculin A and okadiac acid inhibit human platelet aggregation by blocking protein phosphatases types 1 and 2A.
Topics: Blood Platelets; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Humans; Immunoblotting; Marine Toxins; Myosins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin | 1994 |
Characterization of natural toxins with inhibitory activity against serine/threonine protein phosphatases.
Topics: Animals; Antifungal Agents; Cattle; Cyclic AMP-Dependent Protein Kinases; Esterification; Ethers, Cyclic; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Oxidation-Reduction; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylase b; Phosphorylase Kinase; Pyrans; Rabbits; Spiro Compounds | 1994 |
Phosphatase inhibitors suppress Ca2+ influx induced by receptor-mediated intracellular Ca2+ store depletion in human platelets.
Topics: Antifungal Agents; Blood Platelets; Calcium; Ethers, Cyclic; Humans; In Vitro Techniques; Magnesium; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Platelet Aggregation Inhibitors; Pyrans; Spiro Compounds; Terpenes; Thapsigargin; Thrombin | 1994 |
Increased phosphorylation of the amino-terminal domain of the low molecular weight neurofilament subunit in okadaic acid-treated neurons.
Topics: Animals; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Ganglia, Spinal; Macromolecular Substances; Marine Toxins; Neurofilament Proteins; Neurons; Okadaic Acid; Oxazoles; Peptide Fragments; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Rats | 1994 |
Regulation of ROMK1 K+ channel activity involves phosphorylation processes.
Topics: Adenosine Triphosphate; Animals; Cloning, Molecular; Cyclic AMP-Dependent Protein Kinases; Ethers, Cyclic; Female; Ion Channel Gating; Kidney; Kinetics; Magnesium; Marine Toxins; Membrane Potentials; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Time Factors; Vanadates; Xenopus | 1994 |
Presence of protein phosphatase type 1 and its involvement in temperature-dependent flagellar movement of fowl spermatozoa.
Topics: Animals; Blotting, Western; Chickens; Ethers, Cyclic; Hot Temperature; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Sperm Motility; Sperm Tail; Spermatozoa | 1994 |
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation.
Topics: Adenosine Triphosphate; Animals; Benzoquinones; Calcium; Cell Line; Cell Nucleus; Colforsin; Cricetinae; Cytosol; Diacylglycerol Kinase; Epidermal Growth Factor; Ethers, Cyclic; Homeostasis; Kinetics; Lactams, Macrocyclic; Leiomyosarcoma; Marine Toxins; Mesocricetus; Models, Biological; Muscle, Smooth; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Quinazolines; Quinazolinones; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
In vitro neutralization of the inhibitory effect of Microcystin-LR to protein phosphatase 2A by antibody against the toxin.
Topics: Animals; Antibodies; Antibody Specificity; Ethers, Cyclic; Marine Toxins; Mice; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rabbits | 1994 |
Multidrug-resistant human KB carcinoma cells are highly resistant to the protein phosphatase inhibitors okadaic acid and calyculin A. Analysis of potential mechanisms involved in toxin resistance.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Drug Resistance; Ethers, Cyclic; Humans; KB Cells; Marine Toxins; Membrane Glycoproteins; Neoplasm Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Photochemistry; Verapamil | 1993 |
The coupling of multiple signal transduction pathways with steroid response mechanisms.
Topics: Dexamethasone; Drug Synergism; Ethers, Cyclic; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Growth Substances; Humans; Luciferases; Marine Toxins; Okadaic Acid; Oxazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Phosphotransferases; Promoter Regions, Genetic; Protein Kinases; Protein Phosphatase 1; Signal Transduction; Time Factors | 1994 |
Protein phosphatase inhibitors induce the release of serotonin from rat basophilic leukemia cells (RBL-2H3).
Topics: Alkaloids; Animals; Calcium; Ethers, Cyclic; Leukemia, Basophilic, Acute; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured | 1994 |
Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A.
Topics: Cells, Cultured; Ethers, Cyclic; Glycine; Hippocampus; Marine Toxins; Membrane Potentials; N-Methylaspartate; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Receptors, N-Methyl-D-Aspartate | 1994 |
Inhibitors of serine/threonine phosphatases enhance phosphorylation of the interferon-gamma receptor while selectively attenuating interferon-gamma-induced gene expression in human peripheral-blood monocytes.
Topics: Base Sequence; Ethers, Cyclic; Gene Expression Regulation; Genes, Immediate-Early; Humans; In Vitro Techniques; Interferon gamma Receptor; Interferon-gamma; Marine Toxins; Molecular Sequence Data; Monocytes; Okadaic Acid; Oligodeoxyribonucleotides; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Interferon | 1994 |
Two glucose-signaling pathways in S14 gene transcription in primary hepatocytes: a common role of protein phosphorylation.
Topics: Animals; Cells, Cultured; Ethers, Cyclic; Glucose; Liver; Male; Mammary Tumor Virus, Mouse; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Phosphatase 2; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Thyroid Hormone; Signal Transduction; Thymidine Kinase; Transcription Factors; Transcription, Genetic; Transfection | 1994 |
Characterization of serine/threonine protein phosphatases in RINm5F insulinoma cells.
Topics: Animals; Ethers, Cyclic; In Vitro Techniques; Insulinoma; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Pancreatic Neoplasms; Peptides, Cyclic; Phosphoprotein Phosphatases; Rabbits; Rats; Tumor Cells, Cultured | 1993 |
Cytosolic protein phosphatase may turn off activated NADPH oxidase in guinea pig neutrophils.
Topics: Animals; Cytosol; Enzyme Activation; Ethers, Cyclic; Female; Guinea Pigs; Kinetics; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Differential effects of calyculin A and okadaic acid on the glucose-induced regulation of glycogen synthase and phosphorylase activities in cultured hepatocytes.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Ethers, Cyclic; Glucose; Glycogen; Glycogen Synthase; Liver; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylases; Rats; Rats, Sprague-Dawley; Up-Regulation | 1993 |
Phosphatase inhibitors, gap junctional intercellular communication and [125I]-EGF binding in hamster fibroblasts.
Topics: Aluminum Compounds; Animals; Cell Communication; Cell Line; Connexin 43; Cricetinae; Cricetulus; Embryo, Mammalian; Epidermal Growth Factor; Ethers, Cyclic; Fibroblasts; Fluorides; Intercellular Junctions; Iodine Radioisotopes; Kinetics; Lung; Marine Toxins; Mesocricetus; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tetradecanoylphorbol Acetate; Vanadates; Vanadium Compounds | 1993 |
Protein phosphatase activity is required for light-inducible gene expression in maize.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chloramphenicol O-Acetyltransferase; Chlorophyll; Cloning, Molecular; Conserved Sequence; DNA Primers; Electroporation; Ethers, Cyclic; Gene Expression Regulation; Kinetics; Light; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Phosphatase 1; Protoplasts; Pyruvate, Orthophosphate Dikinase; Rabbits; Recombinant Fusion Proteins; Ribulose-Bisphosphate Carboxylase; Sequence Homology, Amino Acid; Transcription, Genetic; Transcriptional Activation; Zea mays | 1993 |
Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants.
Topics: Alkaloids; Apoptosis; Breast Neoplasms; Carbazoles; DNA; Drug Synergism; Ethers, Cyclic; Humans; Indoles; Lymphoma, Large B-Cell, Diffuse; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Recombinant Proteins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage.
Topics: Animals; Apoptosis; Binding Sites; Dexamethasone; DNA; Electrophoresis, Agar Gel; Ethers, Cyclic; Hybridomas; Luciferases; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Plasmids; Protein Phosphatase 1; Receptors, Glucocorticoid; T-Lymphocytes; Transfection | 1993 |
Increase of labeling indices in gastrointestinal mucosae of mice and rats by compounds of the okadaic acid type.
Topics: Administration, Oral; Animals; Antifungal Agents; Bromodeoxyuridine; Carcinogens; Cell Division; Dose-Response Relationship, Drug; Ethers, Cyclic; Intestinal Mucosa; Male; Marine Toxins; Mice; Mice, Inbred ICR; Okadaic Acid; Oxazoles; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Time Factors | 1994 |
Okadaic acid-dependent induction of the urokinase-type plasminogen activator gene associated with stabilization and autoregulation of c-Jun.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Base Sequence; Binding Sites; Blotting, Southern; Blotting, Western; Cell Line; Chloramphenicol O-Acetyltransferase; Colchicine; Cycloheximide; DNA Mutational Analysis; DNA-Binding Proteins; Enzyme Induction; Ethers, Cyclic; Gene Expression Regulation, Enzymologic; Genes, Regulator; Homeostasis; Kinetics; Marine Toxins; Molecular Sequence Data; Nuclear Proteins; Okadaic Acid; Oligodeoxyribonucleotides; Oxazoles; Phosphorylation; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-jun; Time Factors; Transcriptional Activation; Transfection; Urokinase-Type Plasminogen Activator | 1994 |
Phosphorylation down-regulates the store-operated Ca2+ entry pathway of human neutrophils.
Topics: Calcium; Calcium-Transporting ATPases; Ethers, Cyclic; Humans; In Vitro Techniques; Manganese; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Terpenes; Thapsigargin | 1994 |
Calyculin A, protein phosphatase inhibitor, enhances capacitation of human sperm.
Topics: Acrosome; Chlortetracycline; Ethers, Cyclic; Fluorescence; Humans; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Sperm Capacitation; Spermatozoa | 1993 |
Calcium influx and protein phosphorylation mediate the metabolic stabilization of synaptic acetylcholine receptors in muscle.
Topics: Alkaloids; Animals; Bucladesine; Calcium; Calcium Channels; Cyclic AMP; Dibutyryl Cyclic GMP; Dihydropyridines; Electric Stimulation; Ethers, Cyclic; Kinetics; Male; Marine Toxins; Motor Endplate; Muscle Denervation; Muscles; Okadaic Acid; Organ Culture Techniques; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Staurosporine; Synapses; Tetrodotoxin; Time Factors | 1993 |
Neutrophils stimulated with a chemotactic peptide or a phorbol ester exhibit different alterations in the activities of a battery of protein kinases.
Topics: Animals; Ethers, Cyclic; Guinea Pigs; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Substrate Specificity; Tetradecanoylphorbol Acetate | 1993 |
Dual effect of phosphatase inhibitors on calcium channels in intestinal smooth muscle cells.
Topics: Animals; Barium; Calcium Channels; Colon; Dose-Response Relationship, Drug; Electric Conductivity; Ethers, Cyclic; Guinea Pigs; Marine Toxins; Muscle, Smooth; Okadaic Acid; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation | 1993 |
Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1.
Topics: Animals; Cell Cycle; Cell Survival; DNA Replication; Ethers, Cyclic; Liver; Male; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Oxidation-Reduction; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinases; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Wistar | 1993 |
Okadaic acid-induced actin assembly in neutrophils: role of protein phosphatases.
Topics: Actins; Adenosine Triphosphate; Cell Movement; Cytoskeleton; Ethers, Cyclic; GTP-Binding Proteins; Humans; Marine Toxins; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Molecular Weight; Myosin-Light-Chain Kinase; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Protein Kinase C; Protein Kinases; Receptors, Cell Surface | 1993 |
The possible involvement of protein phosphatase 1 in thrombin-induced Ca2+ influx of human platelets.
Topics: Antifungal Agents; Blood Platelets; Calcium; Calcium Channels; Ethers, Cyclic; Humans; Manganese; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Platelet Aggregation; Protein Phosphatase 1; Pyrans; Spiro Compounds; Thrombin | 1993 |
Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors.
Topics: Animals; Autophagy; Cytoskeleton; Energy Metabolism; Ethers, Cyclic; Liver; Lysosomes; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinases; Proteins; Raffinose; Rats; Rats, Wistar; Vacuoles | 1993 |
Intracellular ATP and GTP are both required to preserve modulation of N-type calcium channel current by norepinephrine.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Calcium Channels; Ethers, Cyclic; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Kinetics; Marine Toxins; Neurons; Norepinephrine; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rana catesbeiana; Sympathetic Nervous System; Vasoconstrictor Agents | 1993 |
An essential role for protein phosphatases in hippocampal long-term depression.
Topics: Animals; Calcium; Calmodulin; Electric Stimulation; Ethers, Cyclic; Hippocampus; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1993 |
Calyculin A inhibits the exposure of fibrinogen receptor in thrombin-stimulated platelets.
Topics: Adult; Blood Platelets; Dose-Response Relationship, Drug; Ethers, Cyclic; Humans; In Vitro Techniques; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Phosphatase 1; Thrombin | 1993 |
Inhibition of an archaeal protein phosphatase activity by okadaic acid, microcystin-LR, or calyculin A.
Topics: Enzyme Activation; Ethers, Cyclic; Marine Toxins; Methanosarcina; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Species Specificity; Substrate Specificity | 1993 |
Glucose transport in L6 myoblasts overexpressing GLUT1 and GLUT4.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; Deoxyglucose; Ethers, Cyclic; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Humans; Insulin; Marine Toxins; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats | 1993 |
Protein phosphatase inhibitors induce the selective breakdown of stable microtubules in fibroblasts and epithelial cells.
Topics: 3T3 Cells; Animals; Cell Line; Chlorocebus aethiops; Epithelium; Ethers, Cyclic; Fibroblasts; Kidney; Kinetics; Marine Toxins; Mice; Microtubules; Nocodazole; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Time Factors; Tubulin | 1993 |
Regulation by cell volume of Na(+)-K(+)-2Cl- cotransport in vascular endothelial cells: role of protein phosphorylation.
Topics: Animals; Aorta; Carbazoles; Carrier Proteins; Cattle; Cells, Cultured; Endothelium, Vascular; Ethers, Cyclic; Indole Alkaloids; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Proteins; Sodium-Potassium-Chloride Symporters; Vasoconstrictor Agents | 1993 |
Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein.
Topics: Aged; Alzheimer Disease; Amyloid; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cantharidin; Cell Line; Endopeptidases; Enzyme Inhibitors; Ethers, Cyclic; Humans; Immunoblotting; Marine Toxins; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Prion Proteins; Prions; Protein Phosphatase 1; Protein Precursors | 1995 |
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers, Cyclic; Female; Hydrogen Peroxide; Marine Toxins; Mice; Mice, Inbred Strains; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Skin; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1996 |
d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.
Topics: Amino Acid Sequence; Animals; Antioxidants; Aorta; Cell Cycle; Cell Division; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers, Cyclic; Flow Cytometry; Isomerism; Kinetics; Marine Toxins; Molecular Sequence Data; Muscle, Smooth, Vascular; Naphthalenes; Okadaic Acid; Oligopeptides; Oxazoles; Protein Kinase C; Rats; Substrate Specificity; Tetradecanoylphorbol Acetate; Thymidine; Vitamin E | 1995 |
Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones.
Topics: Alkaline Phosphatase; Bucladesine; Clone Cells; Colforsin; Cyclosporine; Dinoprostone; DNA-Binding Proteins; Enzyme Inhibitors; Ethers, Cyclic; Female; Humans; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Marine Toxins; NFATC Transcription Factors; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Placenta; Pregnancy; Protein Phosphatase 1; Recombinant Proteins; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tumor Cells, Cultured | 1996 |
Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24).
Topics: Apoptosis; DNA; Enzyme Activation; Ethers, Cyclic; Humans; Lymphoma, Large B-Cell, Diffuse; Marine Toxins; Okadaic Acid; Oxazoles; Serine Endopeptidases; Sphingomyelin Phosphodiesterase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 1996 |
The effect of okadaic acid and calyculin A on cholesterol esterification in rat hepatocytes.
Topics: Animals; Cholesterol Esters; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Female; In Vitro Techniques; Kinetics; Liver; Marine Toxins; Okadaic Acid; Oxazoles; Perfusion; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase | 1995 |
Adenosine A2 receptor occupancy regulates stimulated neutrophil function via activation of a serine/threonine protein phosphatase.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Carbazoles; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Humans; In Vitro Techniques; Indoles; Kinetics; Marine Toxins; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Purinergic P1 Receptor Agonists; Pyrroles; Superoxides | 1996 |
The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis.
Topics: Acids; Apoptosis; Caenorhabditis elegans Proteins; Cantharidin; Caspase 1; Caspases; Cysteine Endopeptidases; DNA; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Etoposide; Helminth Proteins; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Phosphatase 1; Protein Phosphatase 2; Retinoblastoma Protein; S Phase; Tumor Cells, Cultured | 1996 |
Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: Involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Binding Sites; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Histamine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoquinolines; Maleimides; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Ryanodine; Spectrometry, Fluorescence; Staurosporine; Sulfonamides | 1996 |
Inhibitors of serine/threonine phosphoprotein phosphatases alter circadian properties in Gonyaulax polyedra.
Topics: Animals; Cantharidin; Cells, Cultured; Circadian Rhythm; Dinoflagellida; Enzyme Inhibitors; Ethers, Cyclic; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1 | 1996 |
Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Marine Toxins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Neurofibrillary Tangles; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Rats; tau Proteins; Transfection | 1995 |
Protein phosphatase inhibitors potentiate Ca2+/calmodulin-dependent protein kinase II activity in rat pancreatic acinar cells.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cholecystokinin; Cyclosporine; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; In Vitro Techniques; Male; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley | 1996 |
Role for protein phosphatase in the regulation of Ca2+ influx in parotid gland acinar cells.
Topics: Animals; Calcium; Carbachol; Enzyme Inhibitors; Male; Manganese; Marine Toxins; Okadaic Acid; Oxazoles; Parotid Gland; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Rats; Rats, Wistar; Stimulation, Chemical; Thapsigargin; Vanadates | 1996 |
Calyculin A, a phosphoprotein phosphatase inhibitor, stimulates acid secretion in isolated gastric glands.
Topics: 4-Nitrophenylphosphatase; Animals; Cyclic AMP; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Rabbits; Stimulation, Chemical | 1996 |
Permeability characteristics of erythrocyte membrane to okadaic acid and calyculin A.
Topics: Animals; Cell Membrane Permeability; Dose-Response Relationship, Drug; Erythrocyte Membrane; Marine Toxins; Okadaic Acid; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Rabbits; Time Factors | 1996 |
Effects of the phosphatase inhibitors calyculin A and okadaic acid on acetylcholine synthesis and content of rat hippocampal formation.
Topics: Acetylcholine; Animals; Choline; Choline O-Acetyltransferase; Hippocampus; In Vitro Techniques; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley | 1996 |
Regulation of alpha 4 integrin avidity in human B cells: requirement for dephosphorylation events for high avidity VCAM-1 binding.
Topics: B-Lymphocytes; Cell Adhesion; Cell Line; Ethers, Cyclic; Humans; Integrin alpha4beta1; Integrins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Receptors, Lymphocyte Homing; Signal Transduction; Vascular Cell Adhesion Molecule-1 | 1996 |
Evidence that the endogenous histone H1 phosphatase in HeLa mitotic chromosomes is protein phosphatase 1, not protein phosphatase 2A.
Topics: Cell Nucleus; Chromatin; Enzyme Inhibitors; HeLa Cells; Histones; Humans; Kinetin; Marine Toxins; Metaphase; Microcystins; Mitosis; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Purines; Staurosporine | 1996 |
Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood.
Topics: Actin Depolymerizing Factors; Androstadienes; Animals; Calcimycin; Calcium; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Ethers, Cyclic; Humans; Ionophores; Marine Toxins; Microfilament Proteins; N-Formylmethionine Leucyl-Phenylalanine; Nerve Tissue Proteins; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Swine; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Phosphatase inhibitors promote ICAM-1 and LFA-1 mediated homotypic aggregation of Jurkat and U937 cells.
Topics: Cell Aggregation; Cell Line; Enzyme Inhibitors; Ethers, Cyclic; Humans; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases | 1996 |
Inhibitions of protein kinases and protein phosphatases have opposite effects on thyrotropin-stimulated cAMP accumulation in human thyroid cells.
Topics: Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Thyroid Gland; Thyrotropin; Time Factors | 1996 |
Sperm motility development in the epididymis is associated with decreased glycogen synthase kinase-3 and protein phosphatase 1 activity.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Drug Stability; Enzyme Inhibitors; Epididymis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hot Temperature; Male; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Sperm Motility; Spermatozoa | 1996 |
Primate sperm contain protein phosphatase 1, a biochemical mediator of motility.
Topics: Adult; Animals; Enzyme Inhibitors; Humans; Macaca mulatta; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylase a; Protein Phosphatase 1; Protein Phosphatase 2; Sperm Motility; Spermatozoa | 1996 |
The rat osteocalcin fibroblast growth factor (FGF)-responsive element: an okadaic acid-sensitive, FGF-selective transcriptional response motif.
Topics: Animals; Cell Line; DNA; Enzyme Inhibitors; Fibroblast Growth Factor 2; Growth Substances; Marine Toxins; Mice; Okadaic Acid; Osteocalcin; Oxazoles; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Rats; Receptors, Fibroblast Growth Factor; Vanadates | 1996 |
Role of phosphoprotein phosphatases in the corpus luteum: I identification and characterisation of serine/threonine phosphoprotein phosphatases in isolated rat luteal cells.
Topics: Animals; Antifungal Agents; Calcineurin; Calmodulin-Binding Proteins; Cantharidin; Cells, Cultured; Corpus Luteum; Dose-Response Relationship, Drug; Female; Marine Toxins; Microcystins; Molecular Weight; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Pyrans; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiro Compounds | 1996 |
Role of phosphoprotein phosphatases in the corpus luteum: II control of progesterone secretion by isolated rat luteal cells.
Topics: Animals; Bucladesine; Cantharidin; Cells, Cultured; Corpus Luteum; Cyclic AMP; Dose-Response Relationship, Drug; Female; Luteinizing Hormone; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Progesterone; Rats; Rats, Sprague-Dawley | 1996 |
Regulation of human basophil function by phosphatase inhibitors.
Topics: Basophils; Cells, Cultured; Enzyme Inhibitors; Histamine Release; Humans; Immunoglobulin E; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases | 1996 |
Evidence for a phorbol ester-insensitive phosphorylation step in capacitative calcium entry in rat thymic lymphocytes.
Topics: Animals; Biological Transport; Calcium; Enzyme Inhibitors; Ion Transport; Lymphocytes; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Thapsigargin; Thymus Gland | 1996 |
Regulation of the initiation of coronavirus JHM infection in primary oligodendrocytes and L-2 fibroblasts.
Topics: Animals; Bucladesine; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Endosomes; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; L Cells; Marine Toxins; Mice; Molecular Weight; Murine hepatitis virus; Nucleocapsid; Okadaic Acid; Oligodendroglia; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Inbred WF; RNA, Viral; Telencephalon; Transfection; Virus Replication | 1996 |
Protein phosphatase activity is required for prothoracicotropic hormone-stimulated ecdysteroidogenesis in the prothoracic glands of the tobacco hornworm, Manduca sexta.
Topics: Animals; Ecdysteroids; Ganglia, Invertebrate; Insect Hormones; Manduca; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Ribosomal Protein S6; Ribosomal Proteins; Sirolimus; Steroids | 1996 |
Regulation of natural killer cell-mediated cytotoxicity by serine/threonine phosphatases: identification of a calyculin A-sensitive serine/threonine kinase.
Topics: CD28 Antigens; Cell Line; Cytotoxicity, Immunologic; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Enzyme Stability; Ionophores; Killer Cells, Natural; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
Okadaic acid enhances prostaglandin E1-induced alkaline phosphatase activity in osteoblast-like cells: regulation at a point downstream from protein kinase A.
Topics: Alkaline Phosphatase; Alprostadil; Animals; Antifungal Agents; Bucladesine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers, Cyclic; Inositol Phosphates; Mice; Okadaic Acid; Osteoblasts; Oxazoles; Pyrans; Spiro Compounds | 1996 |
Inhibition of bradykinin-induced calcium increase by phosphatase inhibitors in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Animals; Bradykinin; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glioma; Hybrid Cells; Marine Toxins; Mice; Neuroblastoma; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Signal Transduction; Thapsigargin; Type C Phospholipases | 1997 |
The protein phosphatase inhibitors okadaic acid and calyculin A induce apoptosis in human osteoblastic cells.
Topics: Animals; Apoptosis; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Humans; Marine Toxins; Mice; Okadaic Acid; Osteoblasts; Oxazoles; Phosphoprotein Phosphatases; Tumor Cells, Cultured | 1997 |
A molecular basis for different interactions of marine toxins with protein phosphatase-1. Molecular models for bound motuporin, microcystins, okadaic acid, and calyculin A.
Topics: Animals; Marine Toxins; Microcystins; Models, Molecular; Monte Carlo Method; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 1; Toxins, Biological | 1997 |
Interphase-like chromatin configuration induced by cycloheximide in maturing pig oocytes: effects of protein phosphatase inhibitors.
Topics: Animals; Chromatin; Cycloheximide; Enzyme Inhibitors; Female; Interphase; Kinetics; Marine Toxins; Microtubules; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Protein Synthesis Inhibitors; Swine; Tubulin | 1996 |
Hyperphosphorylation of beta-catenin on serine-threonine residues and loss of cell-cell contacts induced by calyculin A and okadaic acid in human epidermal cells.
Topics: Apoptosis; beta Catenin; Calcium; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Epidermal Cells; Epidermis; Humans; Intercellular Junctions; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Protein Phosphatase 1; Trans-Activators | 1997 |
Effect of protein phosphatase inhibitors on cleavage furrow formation in newt eggs: inhibition of normal furrow formation and concomitant induction of furrow-like dents.
Topics: Animals; Antifungal Agents; Cleavage Stage, Ovum; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pyrans; Salamandridae; Spiro Compounds | 1997 |
Urea inhibits Na-K-2Cl cotransport in medullary thick ascending limb cells.
Topics: Animals; Binding Sites; Bumetanide; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Kidney Medulla; Loop of Henle; Marine Toxins; Mice; Okadaic Acid; Osmolar Concentration; Oxazoles; Potassium; Sodium-Potassium-Chloride Symporters; Urea | 1997 |
Detection of radiation-induced chromosome aberrations using fluorescence in situ hybridization in drug-induced premature chromosome condensations of tumour cell lines with different radiosensitivities.
Topics: Animals; Cell Cycle; Chromosome Aberrations; Chromosomes; Enzyme Inhibitors; Humans; In Situ Hybridization, Fluorescence; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tumor Cells, Cultured | 1997 |
Low concentrations of the phosphatase inhibitor okadaic acid stop tumor cell locomotion.
Topics: Actins; Animals; Carcinoma 256, Walker; Cell Movement; Cell Size; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunoblotting; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Staining and Labeling; Tumor Cells, Cultured; Vimentin | 1997 |
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin.
Topics: Antifungal Agents; Blotting, Western; Cell Membrane Permeability; Cell-Free System; Down-Regulation; Enzyme Inhibitors; Humans; Intermediate Filaments; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Binding; Protein Phosphatase 1; Protein Processing, Post-Translational; Pyrans; Solubility; Spiro Compounds; Tumor Cells, Cultured | 1997 |
Inhibition of serine-threonine protein phosphatases decreases barrier function of rat pulmonary microvascular endothelial cells.
Topics: Animals; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Intercellular Junctions; Lung; Marine Toxins; Microcirculation; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats | 1997 |
Effect of the protein phosphatase inhibitors, okadaic acid and calyculin A, on dexamethasone-mediated inhibition of neutrophil apoptosis.
Topics: Apoptosis; Cells, Cultured; Dexamethasone; Enzyme Inhibitors; Humans; Kinetics; Marine Toxins; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 1997 |
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.
Topics: Axons; Enzyme Inhibitors; Humans; Marine Toxins; Microtubules; Neurons; Okadaic Acid; Oxazoles; Serine; Threonine; Tumor Cells, Cultured | 1997 |
Involvement of calyculin A inhibitable protein phosphatases in the cyclic AMP signal transduction pathway of mouse corticotroph tumour (AtT20) cells.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenylate Cyclase Toxin; Adrenocorticotropic Hormone; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Pertussis Toxin; Phosphoprotein Phosphatases; Pituitary Neoplasms; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Inhibitors of ser/thr phosphatases 1 and 2A induce apoptosis in pituitary GH3 cells.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; DNA Fragmentation; Enzyme Inhibitors; In Vitro Techniques; L-Lactate Dehydrogenase; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pituitary Gland; Plasmids; Rats; Transfection | 1997 |
Inhibition of B2 receptor internalization delays its dephosphorylation.
Topics: Autoradiography; Bradykinin; Bradykinin Receptor Antagonists; Cantharidin; Cell Line; Concanavalin A; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Humans; Irritants; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Radioligand Assay; Receptor, Bradykinin B2; Receptors, Bradykinin; Skin; Sucrose | 1997 |
Inhibitors of phosphoprotein phosphatases 1 and 2A cause activation of a 53 kDa protein kinase accompanying the apoptotic response of breast cancer cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Phosphatase 1; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 1997 |
Specificity of the test based on modification of cell morphology for detection of lipophilic inhibitors of protein phosphatases.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Lipids; Liver; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Sensitivity and Specificity; Solubility | 1997 |
Control of PHAS-I phosphorylation in 3T3-L1 adipocytes: effects of inhibiting protein phosphatases and the p70S6K signalling pathway.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Carrier Proteins; Cell Cycle Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factors; Fibroblasts; Immune Sera; Immunoblotting; Insulin; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Peptide Initiation Factors; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Polyenes; Rabbits; Repressor Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 1997 |
Colchicine activates actin polymerization by microtubule depolymerization.
Topics: 3T3 Cells; Actins; Animals; Biopolymers; Cell Line; Colchicine; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mice; Microtubules; Okadaic Acid; Oxazoles; Phospholipase D; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rats; Serine; Threonine; Type C Phospholipases | 1997 |
Spontaneous Mn2+ entry is specifically inhibited by calyculin A in human leukemic HL-60 cells.
Topics: Calcium; Colforsin; Depression, Chemical; Dimethyl Sulfoxide; Enzyme Inhibitors; HL-60 Cells; Humans; Manganese; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tetradecanoylphorbol Acetate | 1997 |
Apoptosis induction by inhibitors of Ser/Thr phosphatases 1 and 2A is associated with transglutaminase activation in two different human epithelial tumour lines.
Topics: Apoptosis; Cell Membrane; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Epithelium; HeLa Cells; Humans; L-Lactate Dehydrogenase; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Time Factors; Transglutaminases; Tumor Cells, Cultured | 1997 |
Cofilin undergoes rapid dephosphorylation in stimulated neutrophils and translocates to ruffled membranes enriched in products of the NADPH oxidase complex. Evidence for a novel cycle of phosphorylation and dephosphorylation.
Topics: Actin Depolymerizing Factors; Actins; Amino Acid Sequence; Animals; Calcimycin; Cell Membrane; Diglycerides; Diterpenes; Guinea Pigs; Humans; Hydrogen Peroxide; Immunoblotting; Marine Toxins; Microfilament Proteins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Oxides; Phosphorylation; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1997 |
Modulation of rod photoreceptor cyclic nucleotide-gated channels by tyrosine phosphorylation.
Topics: Adenosine Triphosphate; Animals; Cyclic GMP; Enzyme Inhibitors; Eye Proteins; Hydroquinones; Ion Channel Gating; Marine Toxins; Microcystins; Okadaic Acid; Oocytes; Oxazoles; Patch-Clamp Techniques; Peptides, Cyclic; Phenols; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rod Cell Outer Segment; Staurosporine; Vanadates; Xenopus laevis | 1997 |
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
Topics: Animals; Binding Sites; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rats; Receptor, Insulin; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
Phosphoserine/threonine phosphatases in the rat adrenal cortex: a role in the control of steroidogenesis?
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aldosterone; Animals; Antifungal Agents; Bucladesine; Cells, Cultured; Colforsin; Corticosterone; Enzyme Inhibitors; Immunoblotting; Male; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoric Monoester Hydrolases; Phosphothreonine; Pyrans; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiro Compounds; Stimulation, Chemical | 1997 |
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.
Topics: Antifungal Agents; Crystallography, X-Ray; Enzyme Inhibitors; Marine Toxins; Microcystins; Models, Molecular; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Binding; Protein Conformation; Pyrans; Signal Transduction; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Toxins, Biological | 1997 |
Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase.
Topics: Animals; Cell Line; COUP Transcription Factor II; COUP Transcription Factors; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Hedgehog Proteins; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Promoter Regions, Genetic; Proteins; Receptors, Steroid; Signal Transduction; Trans-Activators; Transcription Factors | 1997 |
A novel assay for evaluating glycogenolysis in rat adipocytes and the inability of insulin to antagonize glycogenolysis in this cell type.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adrenocorticotropic Hormone; Animals; Catecholamines; Cholera Toxin; Cyclic AMP; Enzyme Inhibitors; Glucose; Glycogen; Insulin; Isoproterenol; Lipolysis; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Rats, Wistar; Vanadates | 1997 |
Inhibition of the iron-induced ZmFer1 maize ferritin gene expression by antioxidants and serine/threonine phosphatase inhibitors.
Topics: Abscisic Acid; Antioxidants; Enzyme Inhibitors; Ferritins; Gene Expression Regulation, Plant; Iron; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Transcription, Genetic; Zea mays | 1997 |
Effect of recombinant interleukin-6 and thrombopoietin on isolated guinea pig bone marrow megakaryocyte protein phosphorylation and proplatelet formation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Platelets; Blood Proteins; Bone Marrow Cells; Cell Division; Cells, Cultured; Enzyme Inhibitors; Genistein; Guinea Pigs; Interleukin-1; Interleukin-3; Interleukin-6; Kinetics; Male; Marine Toxins; Megakaryocytes; Okadaic Acid; Oxazoles; Phosphates; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Recombinant Proteins; Thrombopoietin; Thymidine | 1997 |
Protein phosphatase 1 and 2A inhibitors activate acyl-CoA:cholesterol acyltransferase and cholesterol ester formation in isolated rat hepatocytes.
Topics: Animals; Anticholesteremic Agents; Cantharidin; Cells, Cultured; Cholesterol Esters; Enzyme Activation; Enzyme Inhibitors; Female; Liver; Lovastatin; Marine Toxins; Microsomes, Liver; Okadaic Acid; Oleic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase; Time Factors | 1997 |
Okadaic acid-induced decrease in the magnitude and efficacy of the Ca2+ signal in pancreatic beta cells and inhibition of insulin secretion.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Cytoplasm; Energy Metabolism; Enzyme Inhibitors; Ethers, Cyclic; Exocytosis; Female; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 1998 |
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.
Topics: Androstadienes; Binding Sites; Cell Nucleus; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression; Gene Products, tat; HeLa Cells; HIV Long Terminal Repeat; HIV-1; Humans; Jurkat Cells; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Serine; Sp1 Transcription Factor; tat Gene Products, Human Immunodeficiency Virus; Transcription, Genetic; Wortmannin | 1998 |
Transient exposure of rhesus macaque oocytes to calyculin-A and okadaic acid stimulates germinal vesicle breakdown permitting subsequent development and fertilization.
Topics: Animals; Cytoplasm; Enzyme Inhibitors; Female; Fertilization in Vitro; Immunohistochemistry; Macaca mulatta; Male; Marine Toxins; Meiosis; Okadaic Acid; Oocytes; Ovarian Follicle; Oxazoles; Phosphoprotein Phosphatases | 1998 |
The mutant plasmacytoma cell line S107 allows the identification of distinct pathways leading to NF-kappaB activation.
Topics: Animals; DNA; DNA-Binding Proteins; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; I-kappa B Proteins; MAP Kinase Kinase Kinase 1; Marine Toxins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Plasmacytoma; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrrolidines; Signal Transduction; Thiocarbamates; Transcription Factor RelB; Transcription Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Inhibition of p130cas tyrosine phosphorylation by calyculin A.
Topics: Cell Aggregation; Crk-Associated Substrate Protein; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinases; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Protozoan Proteins; Retinoblastoma-Like Protein p130; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
A protein phosphatase is involved in the inhibition of histone deacetylation by sodium butyrate.
Topics: Acetyltransferases; Butyrates; Butyric Acid; Histone Acetyltransferases; Histone Deacetylases; Histones; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Saccharomyces cerevisiae Proteins | 1998 |
Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Casein Kinases; Cells, Cultured; Enzyme Inhibitors; Escherichia coli; HeLa Cells; Homeostasis; Humans; Isoenzymes; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Rats | 1998 |
Modulation of the growth of Plasmodium falciparum in vitro by protein serine/threonine phosphatase inhibitors.
Topics: Animals; Cell Division; Culture Media; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Plasmodium falciparum; Protein Phosphatase 1; Protein Phosphatase 2; Time Factors | 1998 |
Inhibition of a K+ conductance by the phosphatase inhibitor calyculin A in rat distal colon.
Topics: Animals; Colon; Cyclic AMP; Electric Conductivity; Enzyme Inhibitors; Female; Genistein; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Potassium Channel Blockers; Potassium Channels; Protein-Tyrosine Kinases; Rats; Rats, Wistar | 1998 |
Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes.
Topics: Animals; Apoptosis; Cell Aggregation; Cells, Cultured; Eukaryota; Liver; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Pyrans; Rats | 1998 |
Taurine might be acting as a trophic factor in the retina by modulating phosphorylation of cellular proteins.
Topics: Animals; Antineoplastic Agents, Hormonal; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Eye Proteins; Goldfish; Growth Substances; Indoles; Lactams; Marine Toxins; Okadaic Acid; Optic Nerve; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Retina; Sulfonamides; Tamoxifen; Taurine; Tetradecanoylphorbol Acetate | 1998 |
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways.
Topics: Cytokines; DNA; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-1; Janus Kinase 2; Marine Toxins; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrphostins | 1998 |
Disruption of insulin-like growth factor-1 signaling and down-regulation of cdc2 by SC-alphaalphadelta9, a novel small molecule antisignaling agent identified in a targeted array library.
Topics: Animals; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cell Division; Cell Line; Cell Transformation, Viral; Down-Regulation; Enzyme Inhibitors; Female; Insulin-Like Growth Factor I; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pregnancy; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Receptor, IGF Type 1; Signal Transduction; Structure-Activity Relationship; Tyrosine; Vanadates | 1998 |
Okadaic acid-induced lens epithelial cell apoptosis requires inhibition of phosphatase-1 and is associated with induction of gene expression including p53 and bax.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Cell Survival; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Genes, p53; Lens, Crystalline; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rabbits | 1998 |
Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase.
Topics: Animals; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Kidney; Male; Marine Toxins; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 1998 |
Characterization of protein serine/threonine phosphatase activities in human lung mast cells and basophils.
Topics: Basophils; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Lung; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 1998 |
Beta 1 integrin-dependent binding of Jurkat cells to fibronectin is regulated by a serine-threonine phosphatase.
Topics: CD3 Complex; Fibronectins; Humans; Integrin beta1; Jurkat Cells; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Signal Transduction | 1998 |
Expression and characterization of PP7, a novel plant protein Ser/Thr phosphatase distantly related to RdgC/PPEF and PP5.
Topics: Arabidopsis; Arabidopsis Proteins; Calcium-Binding Proteins; Carboxylic Acids; Caseins; Catalytic Domain; Cations, Divalent; Drosophila Proteins; Escherichia coli; Fumonisins; Glycoproteins; Heparin; Hydrogen-Ion Concentration; Inclusion Bodies; Marine Toxins; Myelin Basic Protein; Nitrophenols; Okadaic Acid; Organophosphorus Compounds; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Polylysine; Pregnancy Proteins; Recombinant Fusion Proteins; Substrate Specificity | 1998 |
Temperature-dependent flagellar motility of demembranated, cytosol-free fowl spermatozoa.
Topics: Animals; Calcium; Cell Membrane; Cell Separation; Chelating Agents; Chickens; Cytosol; Detergents; Egtazic Acid; Enzyme Inhibitors; Male; Marine Toxins; Myosin Light Chains; Octoxynol; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Povidone; Protein Kinases; Silicon Dioxide; Sperm Motility; Sperm Tail; Spermatozoa; Temperature | 1998 |
Regulation of the L-type Ca2+ channel current in rat pinealocytes: role of basal phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Alkaloids; Animals; Antifungal Agents; Calcium Channels; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Indoles; Isoproterenol; Isoquinolines; Male; Marine Toxins; Membrane Potentials; Nerve Tissue Proteins; Norepinephrine; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Phosphorylation; Pineal Gland; Protein Kinase C; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Sulfonamides; Sympathomimetics | 1999 |
Effects of calyculin A and okadaic acid on acetylcholine release and subcellular distribution in rat hippocampal formation.
Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Enzyme Inhibitors; Hippocampus; Male; Marine Toxins; Neurotransmitter Agents; Okadaic Acid; Organ Culture Techniques; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Synaptic Vesicles; Tritium | 1999 |
Transcriptional interferences between normal or mutant androgen receptors and the activator protein 1--dissection of the androgen receptor functional domains.
Topics: Aldehyde Reductase; Androgens; Animals; Breast Neoplasms, Male; COS Cells; DNA; Enzyme Inhibitors; Genes, Reporter; Genetic Engineering; Humans; Luciferases; Male; Marine Toxins; Mice; Mutation; Okadaic Acid; Oxazoles; Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Androgen; Staurosporine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection | 1999 |
N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells.
Topics: Animals; Cardiolipins; Cell Line; Cell Membrane Permeability; Ceramides; Cyclic AMP-Dependent Protein Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Ligases; Marine Toxins; Mitochondria, Heart; Myocardium; Nucleotides; Okadaic Acid; Oxazoles; Phosphatidylglycerols; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Rats; Sphingosine; Tumor Necrosis Factor-alpha | 1999 |
Rapid dephosphorylation of p107 following UV irradiation.
Topics: 3T3 Cells; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; E2F Transcription Factors; Enzyme Activation; Enzyme Inhibitors; G1 Phase; Humans; Marine Toxins; Mice; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Retinoblastoma-Binding Protein 1; Retinoblastoma-Like Protein p107; Substrate Specificity; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 1999 |
Molecular characterization of catalytic-subunit cDNA sequences encoding protein phosphatases 1 and 2A and study of their roles in the gibberellin-dependent Osamy-c expression in rice.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Catalytic Domain; DNA, Complementary; DNA, Plant; Enzyme Inhibitors; Germination; Gibberellins; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oryza; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Rabbits; Sequence Alignment; Signal Transduction | 1999 |
Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neurons.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Dopamine and cAMP-Regulated Phosphoprotein 32; Drug Combinations; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Neostriatum; Nerve Tissue Proteins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2 | 1999 |
TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells.
Topics: Acetylcysteine; Blotting, Northern; Calcimycin; Calcium; Carcinogens; Cells, Cultured; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Interleukin-1; Ionophores; Marine Toxins; Membrane Proteins; Okadaic Acid; Oxazoles; Phospholipases A; Phospholipases A2; Protein Kinase C; Reactive Oxygen Species; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Umbilical Veins | 1999 |
Augmentation of methylprednisolone-induced differentiation of myeloid leukemia cells by serine/threonine protein phosphatase inhibitors.
Topics: Cell Death; Cell Differentiation; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia, Myeloid; Marine Toxins; Methylprednisolone; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 1999 |
Role of tyrosine phosphorylation of flagellar proteins in hamster sperm hyperactivation.
Topics: Animals; Bucladesine; Cricetinae; Culture Media; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Kinetics; Male; Marine Toxins; Mesocricetus; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Sperm Capacitation; Sperm Tail; Spermatozoa | 1999 |
Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Enzyme Inhibitors; Insulin; Marine Toxins; Okadaic Acid; Oxazoles; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; Rats | 1999 |
Enzyme activity and protein of multiple forms of choline acetyltransferase: effects of calyculin A and okadaic acid.
Topics: Animals; Choline O-Acetyltransferase; Enzyme Inhibitors; Hippocampus; Isoenzymes; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Subcellular Fractions | 1999 |
Store-operated Ca2+ entry: evidence for a secretion-like coupling model.
Topics: Actins; Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Line, Transformed; Cell Membrane; Cells, Cultured; Cytochalasin D; Cytoskeleton; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate; Ion Channel Gating; Ion Transport; Marine Toxins; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats | 1999 |
The protein phosphatase inhibitors, okadaic acid and calyculin A, induce apoptosis in human submandibular gland ductal cell line HSG cells.
Topics: Apoptosis; Cells, Cultured; Cycloheximide; Dactinomycin; DNA Fragmentation; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Synthesis Inhibitors; Salivary Ducts; Submandibular Gland | 1999 |
Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2a regulates the activities of G(1) cyclin-dependent kinases.
Topics: 3T3 Cells; Animals; Antifungal Agents; Cyclin G; Cyclin G1; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Isoenzymes; Marine Toxins; Mice; Mice, Inbred BALB C; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Pyrans; Retinoblastoma Protein; Spiro Compounds | 1999 |
Mode-specific inhibition of sodium-calcium exchange during protein phosphatase blockade.
Topics: Animals; Barium; Cattle; CHO Cells; Cricetinae; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Sodium-Calcium Exchanger; Spectrometry, Fluorescence; Transfection | 1999 |
Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes.
Topics: Anemia, Sickle Cell; Biological Transport; Carrier Proteins; Cell Size; Cytosol; Dehydration; Enzyme Inhibitors; Erythrocytes; Humans; Ionophores; K Cl- Cotransporters; Marine Toxins; Membrane Proteins; Nystatin; Okadaic Acid; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Serine; Symporters; Threonine; Water-Electrolyte Balance | 1999 |
Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Cycle; Cell Line; Desmin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Marine Toxins; Mice; Microscopy, Confocal; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Proteins; rho-Associated Kinases; Time Factors; Vimentin | 1999 |
Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors.
Topics: 3T3 Cells; Animals; Antifungal Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Cell Line, Transformed; Enzyme Inhibitors; Gene Expression; Humans; Intracellular Fluid; Marine Toxins; Mice; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyrans; Rats; Rats, Wistar; Spiro Compounds; Tumor Cells, Cultured | 1999 |
Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of oatp1.
Topics: Adenosine Triphosphate; Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Kinetics; Liver; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphopeptides; Phosphorylation; Phosphoserine; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Sulfobromophthalein | 2000 |
Synthesis and biological evaluation of a targeted library of protein phosphatase inhibitors.
Topics: Databases as Topic; Drug Design; Enzyme Inhibitors; Ethers, Cyclic; Humans; Indicators and Reagents; Kinetics; Marine Toxins; Microcystins; Models, Molecular; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Structure-Activity Relationship | 2000 |
Serine/threonine phosphorylation in cellular signaling for alveolar macrophage phagocytic response to endotoxin.
Topics: Animals; Cells, Cultured; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages, Alveolar; Male; Marine Toxins; Mitogen-Activated Protein Kinases; Okadaic Acid; Oxazoles; Phagocytosis; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Sprague-Dawley; Signal Transduction | 2000 |
Induction of apoptosis in human oral squamous carcinoma cell lines by protein phosphatase inhibitors.
Topics: Apoptosis; Carcinoma, Squamous Cell; Enzyme Inhibitors; Humans; Marine Toxins; Mouth Neoplasms; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tumor Cells, Cultured | 1999 |
Activation of p38 mitogen-activated protein kinase and mitochondrial Ca(2+)-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A.
Topics: Acetylcysteine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Egtazic Acid; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Heat-Shock Proteins; Imidazoles; Marine Toxins; Mitochondria; Mitogen-Activated Protein Kinases; Molecular Chaperones; Okadaic Acid; Oxazoles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Proline; Promoter Regions, Genetic; Pyridines; Rats; RNA, Messenger; Ruthenium Red; Thiocarbamates; Transcriptional Activation; Tumor Cells, Cultured | 2000 |
Identification of novel serine/threonine protein phosphatases in Trypanosoma cruzi: a potential role in control of cytokinesis and morphology.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Escherichia coli; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; RNA, Messenger; Trypanosoma cruzi | 2000 |
Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cantharidin; Cell Division; Cell Line; Cricetinae; Drug Resistance, Multiple; Enzyme Inhibitors; Gene Expression; Islets of Langerhans; Marine Toxins; Okadaic Acid; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Signal Transduction | 2000 |
Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid.
Topics: Animals; Antifungal Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Pyrans; Pyrethrins; Rats; Receptors, Adrenergic, alpha-1; Spiro Compounds; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Transient translocation and activation of protein phosphatase 2A during mast cell secretion.
Topics: Animals; Antigens; beta-N-Acetylhexosaminidases; Calcimycin; Cell Line; Dinitrophenols; Enzyme Activation; Immunoglobulin E; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Serum Albumin, Bovine; Signal Transduction; Tetradecanoylphorbol Acetate | 2000 |
Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.
Topics: 3T3 Cells; ADAM Proteins; ADAM17 Protein; Animals; Clone Cells; Cloning, Molecular; Colforsin; Disintegrins; Drosophila Proteins; ErbB Receptors; Kinetics; Marine Toxins; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Mice, Knockout; Okadaic Acid; Oxazoles; Protein Isoforms; Receptor, ErbB-4; Recombinant Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate; Thapsigargin; Transfection; Tumor Necrosis Factor-alpha; Vanadates | 2000 |
Cyclic AMP-induced expression of steroidogenic acute regulatory protein is dependent upon phosphoprotein phosphatase activities.
Topics: Adrenal Cortex; Animals; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hydroxycholesterols; Isoenzymes; Kinetics; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoproteins; Pregnenolone; Progesterone; Protein Tyrosine Phosphatases; Steroids | 2000 |
Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition.
Topics: Burkitt Lymphoma; Cell Cycle; Cell Survival; Enzyme Activation; Enzyme Inhibitors; G2 Phase; Humans; Marine Toxins; Microtubules; Mitogen-Activated Protein Kinases; Mitosis; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nocodazole; Okadaic Acid; Oxazoles; Paclitaxel; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinblastine | 2000 |
Effect of okadaic acid and calyculin-A, two protein phosphatase inhibitors, on thyrotropin-stimulated triiodothyronine secretion in cultured sheep thyroid cells.
Topics: Animals; Cells, Cultured; Colforsin; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Sheep; Thyroid Gland; Thyrotropin; Triiodothyronine | 1999 |
Involvement of histone phosphorylation in thymocyte apoptosis by protein phosphatase inhibitors.
Topics: Animals; Apoptosis; Cells, Cultured; Enzyme Inhibitors; Histones; Marine Toxins; Okadaic Acid; Oxazoles; Phosphates; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; T-Lymphocytes; Thymus Gland | 1999 |
Effect of Ca(2+)-independent mechanisms on the hypoxic relaxation of guinea-pig tracheal rings.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Enzyme Inhibitors; Guinea Pigs; Hypoxia; Male; Marine Toxins; Muscle Relaxation; Muscle, Smooth; Okadaic Acid; Oxazoles; Oxygen; Thapsigargin; Trachea | 2000 |
A peptide of the alpha 3(IV) chain of type IV collagen modulates stimulated neutrophil function via activation of cAMP-dependent protein kinase and Ser/Thr protein phosphatase.
Topics: Adenosine; Amino Acid Sequence; Autoantigens; Calcium; Carbazoles; Chelating Agents; Collagen; Collagen Type IV; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine Antagonists; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; Indoles; Marine Toxins; Molecular Sequence Data; Neutrophils; Okadaic Acid; Oxazoles; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Pyrroles; Pyrrolidinones; Respiratory Burst; Signal Transduction; Thapsigargin; Trifluoperazine | 2000 |
Oxygen uptake, acidification of medium and nitrate uptake induced by blue light in nitrate-starved Chlorella cells.
Topics: Biological Transport; Chlorella; Color; Glycine; Light; Marine Toxins; Nitrates; Okadaic Acid; Oxazoles; Oxygen; Phosphoprotein Phosphatases | 2000 |
Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia.
Topics: Animals; Antibodies, Monoclonal; Basal Ganglia; Cattle; Cocaine; Corpus Striatum; Cyclosporine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Illicit Drugs; Marine Toxins; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Rats | 2000 |
Protein phosphatase inhibitors alter cellular microtubules and reduce carbachol-dependent protein secretion in lacrimal acini.
Topics: Animals; Carbachol; Cholinergic Agonists; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eye Proteins; Female; Lacrimal Apparatus; Marine Toxins; Microscopy, Confocal; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rabbits | 2000 |
Inhibition and stimulation of growth of Entamoeba histolytica in culture: association with PKC activity and protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Culture Media; Down-Regulation; Entamoeba histolytica; Enzyme Inhibitors; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Threonine | 2000 |
Inhibition of antigen and calcium ionophore induced secretion from RBL-2H3 cells by phosphatase inhibitors.
Topics: Animals; Antigens; Calcimycin; Calcium; Calcium Signaling; Cell Adhesion; Cell Membrane; Cell Size; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ionophores; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Signal Transduction; Vimentin | 1998 |
Effect of calyculin A on the surface structure of unfertilized sea urchin eggs.
Topics: Acrosome Reaction; Animals; Cytochalasin B; Enzyme Inhibitors; Fertilization; In Vitro Techniques; Marine Toxins; Microscopy, Electron; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Microvilli; Okadaic Acid; Ovum; Oxazoles; Phosphoprotein Phosphatases; Sea Urchins; Sperm-Ovum Interactions | 2000 |
Glucocorticoids abate p70(S6k) and eIF4E function in L6 skeletal myoblasts.
Topics: Cell Line; Dexamethasone; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Glucocorticoids; Marine Toxins; Muscle, Skeletal; Okadaic Acid; Oxazoles; Peptide Initiation Factors; Phosphorylation; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins | 2000 |
Protein kinase C and phosphatase inhibitors block the ability of angiotensin I-converting enzyme inhibitors to resensitize the receptor to bradykinin without altering the primary effects of bradykinin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arachidonic Acid; Bradykinin; Bradykinin Receptor Antagonists; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Drug Interactions; Enalaprilat; Endothelium, Vascular; Enzyme Inhibitors; Humans; Marine Toxins; Naphthalenes; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Pulmonary Artery; Receptor, Bradykinin B2; Receptors, Bradykinin; Transfection | 2000 |
Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.
Topics: Animals; Barium Compounds; Biological Transport; Bumetanide; Carrier Proteins; Chlorides; Ethylmaleimide; Furosemide; Humans; K Cl- Cotransporters; Kinetics; Marine Toxins; Mice; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Potassium; Protein Isoforms; Protein Phosphatase 1; Pyrethrins; Recombinant Proteins; Rubidium; Sharks; Symporters; Xenopus laevis | 2000 |
Phosphatase inhibitors and premature chromosome condensation in human peripheral lymphocytes at different cell-cycle phases.
Topics: Calcimycin; Cell Cycle; Chromosomes, Human; Enzyme Inhibitors; Humans; Ionophores; Lymphocytes; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tetradecanoylphorbol Acetate | 1999 |
beta2-adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase.
Topics: Adaptor Protein Complex beta Subunits; Antifungal Agents; Cell Membrane; Cells, Cultured; Endocytosis; Enzyme Inhibitors; Humans; Jurkat Cells; Marine Toxins; Membrane Proteins; Microscopy, Confocal; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Phosphatase 2; Pyrans; Spiro Compounds; Staurosporine | 2000 |
Stimulation of hepatocyte growth factor production in human fibroblasts by the protein phosphatase inhibitor okadaic acid.
Topics: Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Hepatocyte Growth Factor; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 2000 |
Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A.
Topics: Animals; Antidepressive Agents; Biogenic Amines; Biological Transport; Carrier Proteins; Cell Line; Cocaine; Dopamine Plasma Membrane Transport Proteins; Humans; Macromolecular Substances; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Okadaic Acid; Oxazoles; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Phosphatase 1; Protein Phosphatase 2; Protein Transport; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters; Transfection | 2000 |
Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hepatocytes; Humans; Insulin; Marine Toxins; Mitogen-Activated Protein Kinases; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Multiple signaling pathways in gene expression during sugar starvation. Pharmacological analysis of din gene expression in suspension-cultured cells of Arabidopsis.
Topics: Arabidopsis; Blotting, Northern; Carbohydrates; Cells, Cultured; Cycloheximide; Cytochrome c Group; Darkness; Enzyme Inhibitors; Gene Expression Regulation, Plant; Genes, Plant; Light-Harvesting Protein Complexes; Marine Toxins; Okadaic Acid; Oxazoles; Oxidoreductases; Phosphoprotein Phosphatases; Phosphorylation; Photosynthetic Reaction Center Complex Proteins; Plant Proteins; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction | 2000 |
Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Protein Phosphatase 2; Rats; Rats, Wistar; tau Proteins | 2000 |
A study of the binding requirements of calyculin A and dephosphonocalyculin A with PP1, development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1.
Topics: Crystallography, X-Ray; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; Hydrogen Bonding; Marine Toxins; Microcystins; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphoproteins; Protein Binding | 2001 |
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.
Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection | 2001 |
Concentration-dependent effects of protein phosphatase (PP) inhibitors implicate PP1 and PP2A in different stages of memory formation.
Topics: Animals; Avoidance Learning; Chickens; Enzyme Inhibitors; Marine Toxins; Memory; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Synapses; Time Factors | 2001 |
Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells.
Topics: Blotting, Western; CD4 Antigens; CD8 Antigens; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; T-Lymphocytes; Time Factors; Transcription, Genetic | 2000 |
Protein phosphatase 2A isotypes regulate cell surface expression of the T cell receptor.
Topics: Amino Acid Sequence; Antifungal Agents; CD3 Complex; Down-Regulation; Endocytosis; Enzyme Inhibitors; Exocytosis; Humans; Isoenzymes; Jurkat Cells; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Pyrans; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Transferrin; Spiro Compounds | 2001 |
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2001 |
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Serine; tau Proteins; Threonine; Time Factors; Up-Regulation | 2001 |
Changes in the activities of protein phosphatase type 1 and type 2A in sea urchin embryos during early development.
Topics: Aniline Compounds; Animals; Blastocyst; Egg Proteins; Embryo, Nonmammalian; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Morula; Okadaic Acid; Oocytes; Organophosphorus Compounds; Oxazoles; Phosphoprotein Phosphatases; Sea Urchins; Zygote | 2000 |
Down-regulation of Na-K-Cl cotransport by protein kinase C is mediated by protein phosphatase 1 in pigmented ciliary epithelial cells.
Topics: Carcinogens; Cells, Cultured; Chloride Channels; Ciliary Body; Down-Regulation; Enzyme Inhibitors; Humans; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pigment Epithelium of Eye; Potassium Channels; Protein Kinase C; Protein Phosphatase 1; Rubidium Radioisotopes; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Serine/threonine phosphatase inhibitors decrease adrenergic arylalkylamine n-acetyltransferase induction in the rat pineal gland.
Topics: Animals; Arylamine N-Acetyltransferase; Cyclic AMP Response Element Modulator; DNA-Binding Proteins; Enzyme Induction; Fos-Related Antigen-2; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pineal Gland; Rats; Rats, Sprague-Dawley; Repressor Proteins; RNA, Messenger; Transcription Factors | 2001 |
Phosphorylation of histones triggers DNA fragmentation in thymocyte undergoing apoptosis induced by protein phosphatase inhibitors.
Topics: Animals; Apoptosis; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyribonucleases; DNA Fragmentation; Enzyme Inhibitors; Histones; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Thymus Gland | 2001 |
Regulation of immunoglobulin E-mediated secretion by protein phosphatases in human basophils and mast cells of skin and lung.
Topics: Alkenes; Antifungal Agents; Basophils; Enzyme Inhibitors; Histamine Release; Humans; Immunoglobulin E; Lung; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Polyenes; Pyrans; Pyrones; Skin; Spiro Compounds | 2001 |
Centrosome cohesion is regulated by a balance of kinase and phosphatase activities.
Topics: Antineoplastic Agents; Aurora Kinases; Cell Cycle; Cell Cycle Proteins; Centrosome; Cyclin-Dependent Kinases; Cyclins; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Humans; Marine Toxins; Microtubules; NIMA-Related Kinases; Nocodazole; Nucleic Acid Synthesis Inhibitors; Okadaic Acid; Oxazoles; Paclitaxel; Phosphoprotein Phosphatases; Phosphorylation; Polo-Like Kinase 1; Protein Kinases; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Transfection; Tumor Cells, Cultured; Xenopus Proteins | 2001 |
Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA.
Topics: Animals; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Kidney Concentrating Ability; Kidney Medulla; Kidney Tubules, Collecting; Male; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Urea; Urea Transporters; Vasoconstrictor Agents; Vasopressins | 2002 |
Dynamics of ankyrin-containing complexes in chicken embryonic erythroid cells: role of phosphorylation.
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Ankyrins; Cell Nucleus; Chick Embryo; Enzyme Inhibitors; Erythroid Precursor Cells; Marine Toxins; Okadaic Acid; Oxazoles; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; Solubility; Spectrin | 2001 |
Modulation of microglial superoxide production by alpha-tocopherol in vitro: attenuation of p67(phox) translocation by a protein phosphatase-dependent pathway.
Topics: alpha-Tocopherol; Animals; Antioxidants; Cell Membrane; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Marine Toxins; Mice; Microglia; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Rats; Respiratory Burst; Staurosporine; Superoxides; Swine | 2001 |
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.
Topics: Adenocarcinoma; Alternative Splicing; Base Sequence; bcl-X Protein; Carboxylic Acids; Caspase 9; Caspases; Ceramides; DNA Primers; Enzyme Inhibitors; Fumonisins; Humans; Lung Neoplasms; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Sphingolipids; Tumor Cells, Cultured | 2002 |
Calyculin A sensitive protein phosphatase is required for Bacillus anthracis lethal toxin induced cytotoxicity.
Topics: Animals; Antifungal Agents; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Blotting, Western; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Genistein; MAP Kinase Kinase Kinase 1; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyrans; Signal Transduction; Sphingosine; Spiro Compounds | 2002 |
Cytoskeletal inhibitors, anti-adhesion molecule antibodies, and lectins inhibit hepatocyte spheroid formation.
Topics: Animals; Antibodies; Cadherins; Cell Adhesion Molecules; Cell Size; Cells, Cultured; Colchicine; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Fluorescent Antibody Technique; Glycosylation; Hepatocytes; Lectins; Male; Marine Toxins; Microscopy, Confocal; Nucleic Acid Synthesis Inhibitors; Okadaic Acid; Oxazoles; Rats; Rats, Wistar | 2002 |
Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indole Alkaloids; Indoles; Isoproterenol; Isoquinolines; Maleimides; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Parotid Gland; Peptides, Cyclic; Phenols; Phosphorus Radioisotopes; Phosphorylation; Rats; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Staurosporine; Sulfonamides; Sympathomimetics; Vanadates | 2002 |
The outwardly rectifying chloride channel in rat peritoneal mast cells is regulated by serine/threonine kinases and phosphatases.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chloride Channels; Chlorides; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Male; Marine Toxins; Mast Cells; Membrane Potentials; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Peritoneal Cavity; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Thionucleotides | 2002 |
Mechanically stimulated TCH3 gene expression in Arabidopsis involves protein phosphorylation and EIN6 downstream of calcium.
Topics: Arabidopsis; Arabidopsis Proteins; Calcium; Calcium-Binding Proteins; Dimethyl Sulfoxide; Gene Expression Regulation, Plant; Marine Toxins; Mutation; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Protein Kinase Inhibitors; Receptors, Cell Surface; Signal Transduction; Staurosporine; Stress, Mechanical | 2002 |
Differential regulation of a novel variant of the alpha(6) integrin, alpha(6p).
Topics: Actins; Antigens, CD; Antigens, Surface; Cells, Cultured; Cytochalasin D; Cytoskeleton; Glycoside Hydrolases; Humans; Integrin alpha6; Integrin beta1; Integrins; Marine Toxins; Okadaic Acid; Oxazoles; Protein Processing, Post-Translational; Tumor Cells, Cultured | 2002 |
Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase.
Topics: Animals; Chloride Channels; CLC-2 Chloride Channels; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Kinetics; Kinetin; Marine Toxins; Mitosis; Okadaic Acid; Oocytes; Oxazoles; Phosphorylation; Purines; Recombinant Proteins; Xenopus | 2002 |
PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; HeLa Cells; Humans; Hydrogen Peroxide; Marine Toxins; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Okadaic Acid; Oxazoles; Oxidative Stress; PC12 Cells; Phosphoprotein Phosphatases; Protein Kinase C; Rats | 2002 |
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glutamine; Hepatocytes; Male; Marine Toxins; Multienzyme Complexes; Okadaic Acid; Oligomycins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases; Serine; Sirolimus | 2002 |
Effects of the phosphatase inhibitors, okadaic acid, ATPgammaS, and calyculin A on the dividing sand dollar egg.
Topics: Actins; Adenosine Triphosphate; Animals; Cell Division; Chromosomes; Cleavage Stage, Ovum; Enzyme Inhibitors; Marine Toxins; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Sea Urchins | 2002 |
Characterization of early, chitin-induced gene expression in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Carbazoles; Chitin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Plant; Indole Alkaloids; Lectins; Marine Toxins; Mitogen-Activated Protein Kinase Kinases; Okadaic Acid; Oligosaccharides; Oxazoles; Phosphorylation; Plant Proteins; RNA, Messenger; Signal Transduction; Staurosporine; Transcriptional Activation; Zinc Fingers | 2002 |
Phosphatase inhibitors increase the open probability of ENaC in A6 cells.
Topics: Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Sodium Channels; Ion Channel Gating; Isomerism; Kidney; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Phosphatase 2; Sodium Channels | 2002 |
Protein phosphorylation activates the guard cell Ca2+ channel and is a prerequisite for gating by abscisic acid.
Topics: Abscisic Acid; Adenosine Triphosphate; Algorithms; Calcium; Calcium Channels; Cell Membrane; Enzyme Inhibitors; Evoked Potentials; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plant Epidermis; Plant Proteins; Signal Transduction; Vicia | 2002 |
Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells.
Topics: Adult; Agatoxins; Alkaloids; Benzophenanthridines; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling; Cell Size; Diglycerides; Dimethyl Sulfoxide; Enzyme Inhibitors; Erythrocytes; Humans; Ion Transport; Ionophores; Marine Toxins; Okadaic Acid; Osmotic Fragility; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Protein Kinase C; Spider Venoms; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
Reversible protein phosphorylation regulates the dynamic organization of the pollen tube cytoskeleton: effects of calyculin A and okadaic acid.
Topics: Actin Cytoskeleton; Bridged Bicyclo Compounds, Heterocyclic; Cell Differentiation; Cell Polarity; Cytoskeleton; Enzyme Inhibitors; Fertilization; Flowers; Gene Expression Regulation, Plant; Lilium; Marine Toxins; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Thiazoles; Thiazolidines | 2002 |
Genetic and pharmacological demonstration of a role for cyclic AMP-dependent protein kinase-mediated suppression of protein phosphatases in gating the expression of late LTP.
Topics: Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Hippocampus; Long-Term Potentiation; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Synaptic Transmission | 2002 |
Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin.
Topics: Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Cell Line; Cell Membrane; Down-Regulation; Embryo, Mammalian; Endocytosis; Enzyme Inhibitors; Fluorescent Antibody Technique, Direct; Gene Expression; Green Fluorescent Proteins; Humans; Kidney; Kinetics; Luminescent Proteins; Marine Toxins; Microscopy, Confocal; Mutagenesis, Site-Directed; Okadaic Acid; Opossums; Oxazoles; Parathyroid Hormone; Phosphoprotein Phosphatases; Phosphorylation; Rats; Receptors, Parathyroid Hormone; Recombinant Fusion Proteins; Transfection | 2002 |
Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites.
Topics: Animals; Cattle; Cell Line; COS Cells; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Okadaic Acid; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Protein Phosphatase 2; Serine; Signal Transduction; Threonine; Transfection | 2002 |
Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Interleukin-1; Marine Toxins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Okadaic Acid; Oxazoles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats | 2003 |
Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcineurin; Calcineurin Inhibitors; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Inhibitors; Hippocampus; Male; Marine Toxins; Membrane Potentials; Okadaic Acid; Organ Culture Techniques; Oxazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Theta Rhythm; Xanthines | 2003 |
Ischemia-induced dephosphorylation of cardiomyocyte connexin-43 is reduced by okadaic acid and calyculin A but not fostriecin.
Topics: Alkenes; Animals; Blotting, Western; Cells, Cultured; Connexin 43; Gap Junctions; Gene Expression; Ischemia; Marine Toxins; Myocytes, Cardiac; Okadaic Acid; Oxazoles; Phosphorylation; Polyenes; Pyrones; Rats; Rats, Sprague-Dawley | 2003 |
Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.
Topics: Antigens, Polyomavirus Transforming; Cells, Cultured; Cyclin-Dependent Kinases; Cyclins; DNA; Enzyme Inhibitors; Gene Expression; Humans; Hydrogen Peroxide; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Oxidative Stress; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 2; Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; S Phase; Transfection; Umbilical Veins | 2003 |
Effects of serine/threonine protein phosphatase inhibitors on morphine-induced antinociception in the tail flick test in mice.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cantharidin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Injections, Intraventricular; Marine Toxins; Mice; Morphine; Naloxone; Nociceptors; Okadaic Acid; Oxazoles; Pain; Pain Measurement; Phosphoprotein Phosphatases; Prosencephalon; Synaptosomes; Tritium | 2003 |
CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells.
Topics: Alkenes; Animals; Binding Sites; Calcineurin Inhibitors; Calcium; Cholecystokinin; Cyclic AMP; Cyclosporine; DNA-Binding Proteins; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Polyenes; Pyrones; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors | 2003 |
Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes.
Topics: Animals; Calcium; Calcium Signaling; Enzyme Inhibitors; Ionophores; Male; Marine Toxins; Myocytes, Cardiac; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2003 |
Parallel purification of three catalytic subunits of the protein serine/threonine phosphatase 2A family (PP2A(C), PP4(C), and PP6(C)) and analysis of the interaction of PP2A(C) with alpha4 protein.
Topics: Adaptor Proteins, Signal Transducing; Animals; Anion Exchange Resins; Antibodies; Antibody Specificity; Blotting, Western; Brain; Brain Chemistry; Caseins; Catalytic Domain; Cattle; Chlorocebus aethiops; Chromatography, Affinity; Cloning, Molecular; COS Cells; Ethers, Cyclic; Gene Expression; Glutathione Transferase; Histones; Intercellular Signaling Peptides and Proteins; Liver; Male; Mice; Microcystins; Molecular Chaperones; Molecular Sequence Data; Myocardium; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylase a; Phosphorylation; Precipitin Tests; Protein Binding; Protein Kinases; Protein Phosphatase 2; Rats; Recombinant Fusion Proteins; Resins, Synthetic; Ribosomal Protein S6 Kinases, 70-kDa; Sequence Alignment; Sequence Analysis, Protein; Sirolimus; Testis; Thymus Gland | 2003 |
Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Bryostatins; Calpain; Cell Line, Tumor; Cell Membrane; Cells, Cultured; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Intestinal Mucosa; Lactones; Macrolides; Marine Toxins; Microscopy, Fluorescence; Models, Biological; Multienzyme Complexes; Okadaic Acid; Oxazoles; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Kinase C-alpha; Rats; Signal Transduction; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors; Ubiquitin | 2004 |
Regulating the expression of protein phosphatase type 5.
Topics: Animals; Base Sequence; Binding Sites; Conserved Sequence; DNA Primers; Gene Expression Regulation, Enzymologic; Isoenzymes; Mammals; Marine Toxins; Microcystins; Nuclear Proteins; Okadaic Acid; Oligonucleotides, Antisense; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Recombinant Proteins; RNA, Antisense; RNA, Messenger; Transfection | 2003 |
Protein phosphatase 1 and an opposing protein kinase regulate steady-state L-type Ca2+ current in mouse cardiac myocytes.
Topics: Animals; Biophysical Phenomena; Biophysics; Buffers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Electric Conductivity; Enzyme Inhibitors; Homeostasis; Isoenzymes; Male; Marine Toxins; Mice; Mice, Inbred Strains; Myocytes, Cardiac; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Staurosporine; Thionucleotides | 2004 |
Involvement of histone H3 (Ser10) phosphorylation in chromosome condensation without Cdc2 kinase and mitogen-activated protein kinase activation in pig oocytes.
Topics: Animals; CDC2 Protein Kinase; Chromosomes; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Histones; Marine Toxins; Models, Biological; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Serine; Sus scrofa | 2004 |
Inositol hexakisphosphate and sulfonylureas regulate beta-cell protein phosphatases.
Topics: Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Insulin; Insulin Secretion; Marine Toxins; Muscles; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phytic Acid; Protein Phosphatase 1; Rabbits; Rats; Signal Transduction; Sulfonylurea Compounds | 2004 |
Induction of SULTR1;1 sulfate transporter in Arabidopsis roots involves protein phosphorylation/dephosphorylation circuit for transcriptional regulation.
Topics: Anion Transport Proteins; Arabidopsis; Arabidopsis Proteins; Carrier Proteins; Cycloheximide; Dactinomycin; Gene Expression Regulation, Plant; Green Fluorescent Proteins; Luminescent Proteins; Marine Toxins; Membrane Transport Proteins; Okadaic Acid; Oxazoles; Phosphorylation; Plant Roots; Plants, Genetically Modified; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; Sulfate Transporters; Sulfur | 2004 |
Bone morphogenetic proteins and neurotrophins provide complementary protection of septal cholinergic function during phosphatase inhibitor-induced stress.
Topics: Acetylcholinesterase; Animals; bcl-X Protein; Bone Morphogenetic Proteins; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Embryo, Mammalian; Enzyme Inhibitors; Fluoresceins; Glial Fibrillary Acidic Protein; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Immunohistochemistry; Marine Toxins; Nerve Growth Factors; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Septal Nuclei; Stress, Physiological; tau Proteins; Time Factors; Transfection | 2004 |
Inhibitors of protein phosphatases 1 and 2A differentially prevent intrinsic and extrinsic apoptosis pathways.
Topics: Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Enzyme Inhibitors; Humans; Jurkat Cells; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pyrans; Signal Transduction; Spiro Compounds; U937 Cells | 2004 |
Premature chromosome condensation in human resting peripheral blood lymphocytes for chromosome aberration analysis using specific whole-chromosome DNA hybridization probes.
Topics: Chromosome Aberrations; Chromosome Painting; DNA Probes; Humans; Lymphocytes; Marine Toxins; Microscopy, Fluorescence; Okadaic Acid; Oxazoles | 2005 |
Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons.
Topics: Animals; Blotting, Western; Brain; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Immunoprecipitation; MAP Kinase Kinase 1; Marine Toxins; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Okadaic Acid; Oxazoles; Peptides; Phenylacetates; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Serine; Signal Transduction; Threonine; Time Factors; Up-Regulation | 2005 |
Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores.
Topics: Animals; Benzoxazines; Calcium; Cell Culture Techniques; Cell Death; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclohexanols; Dantrolene; Drug Interactions; Estrenes; Fetus; Hippocampus; Macrocyclic Compounds; Morpholines; N-Methylaspartate; Naphthalenes; Neurons; Neuroprotective Agents; Okadaic Acid; Oxazoles; Piperidines; Pyrazoles; Pyrrolidinones; Rats; Rats, Inbred Strains; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Thionucleotides | 2005 |
PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells.
Topics: Androstadienes; Animals; Becaplermin; Cells, Cultured; Chlorides; Chromones; Cyclosporine; Flavonoids; K Cl- Cotransporters; Marine Toxins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Platelet-Derived Growth Factor; Potassium; Protein Phosphatase 1; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Symporters; Vanadates; Wortmannin | 2005 |
Role of protein phosphatases in estrogen-mediated neuroprotection.
Topics: Animals; Calcineurin; Cell Survival; Cells; Cells, Cultured; Enzyme Inhibitors; Estradiol; Estrogens; Glutamic Acid; Marine Toxins; Neurons; Neuroprotective Agents; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Time Factors | 2005 |
Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex.
Topics: Animals; Calcium; Calmodulin; Cerebral Cortex; Egtazic Acid; Female; Hypoxia; Imidazoles; Marine Toxins; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Protein Phosphatase 1; Pyrethrins; Receptors, N-Methyl-D-Aspartate; Turtles | 2005 |
Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositols; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Phosphatase 1; Protein Phosphatase 2; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Pyrans; RNA, Small Interfering; Serine; Signal Transduction; Spiro Compounds; Subcellular Fractions; Threonine; Time Factors | 2005 |
Inhibition of neuronal nitric-oxide synthase by phosphorylation at Threonine1296 in NG108-15 neuronal cells.
Topics: Animals; Enzyme Inhibitors; Marine Toxins; Mutation; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Okadaic Acid; Oxazoles; Phosphorylation; Rats; Threonine | 2005 |
Inhibition by calyculin A and okadaic acid of the Ca(2+) release-activated Ca(2+) entry pathway in rat basophilic leukemia cells: evidence for regulation by type 1/2A serine/threonine phosphatase activity.
Topics: Animals; Boron Compounds; Calcium; Calcium Signaling; Cations, Divalent; Cells, Cultured; Enzyme Inhibitors; Ion Transport; Leukemia, Basophilic, Acute; Manganese; Marine Toxins; Membrane Potentials; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Thapsigargin | 2005 |
Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Cell Adhesion; Cell Line; Colchicine; Cytochalasin D; Enzyme Inhibitors; Humans; Intermediate Filaments; Marine Toxins; Microtubules; Nocodazole; Nucleic Acid Synthesis Inhibitors; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Phosphatase 2; Pyrans; Serine; Signal Transduction; Spiro Compounds; Threonine; Tubulin Modulators | 2006 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities.
Topics: Amino Acid Substitution; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Epithelial Cells; Genes, bcl-2; Genes, p53; Genes, Reporter; Humans; Immunoprecipitation; Lens, Crystalline; Marine Toxins; Mice; Mice, Knockout; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Protein Binding; Protein Interaction Mapping; Protein Phosphatase 1; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Transcription, Genetic; Tumor Suppressor Protein p53 | 2006 |
Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes.
Topics: Adipocytes; Animals; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Kinetics; Lipolysis; Marine Toxins; Okadaic Acid; Oxazoles; Perilipin-1; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rats; Sterol Esterase | 2006 |
Nicotine reverses consolidated long-term potentiation in the hippocampal CA1 region.
Topics: Aconitine; Analysis of Variance; Animals; Dihydro-beta-Erythroidine; Dose-Response Relationship, Radiation; Drug Administration Schedule; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Ethers, Cyclic; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Okadaic Acid; Oxazoles; Rats; Rats, Sprague-Dawley | 2006 |
Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons.
Topics: Animals; Calcium; Marine Toxins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Propofol; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Tyrosine | 2006 |
Regulation of acrosome reaction of fowl spermatozoa: evidence for the involvement of protein kinase C and protein phosphatase-type 1 and/or -type 2A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome Reaction; Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Cells, Cultured; Chickens; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Signal Transduction; Sperm Motility; Spermatozoa; Stimulation, Chemical; Sulfonamides; Vitelline Membrane | 2006 |
Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A.
Topics: Amiloride; Animals; Cantharidin; Enzyme Inhibitors; Erythrocytes; Ion Transport; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Sodium Fluoride; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1 | 2006 |
The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.
Topics: Adaptor Proteins, Signal Transducing; Allosteric Site; Amino Acid Sequence; Animals; Cantharidin; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Intercellular Signaling Peptides and Proteins; Marine Toxins; Mice; Microcystins; Molecular Chaperones; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Sequence Homology, Amino Acid | 2006 |
Role of protein phosphatase 2A in calcium-dependent chloride secretion by human colonic epithelial cells.
Topics: Calcium; Carbachol; Cells, Cultured; Chlorides; Colon; Epidermal Growth Factor; Gastrointestinal Agents; Humans; Intestinal Mucosa; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2 | 2007 |
Proper chromatin condensation and maintenance of histone H3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity.
Topics: Animals; Chromatin; Chromosomes, Mammalian; Female; HeLa Cells; Histones; Humans; Marine Toxins; Meiosis; Mice; Mice, Inbred Strains; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protamine Kinase; Protein Phosphatase 1; Protein Phosphatase 2 | 2007 |
Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse.
Topics: Cantharidin; Enzyme Inhibitors; Furans; Indole Alkaloids; Lactones; Lipids; Marine Toxins; Microcystins; Okadaic Acid; Organophosphates; Organophosphorus Compounds; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Pyrans; Pyrones; Spiro Compounds | 2007 |
Hybrid lethality in interspecific F1 hybrid Nicotiana gossei x N. tabacum involves a MAP-kinases signalling cascade.
Topics: Butadienes; Cell Line; Cell Survival; Enzyme Inhibitors; Hybridization, Genetic; Hydrogen Peroxide; Immunoblotting; Immunoprecipitation; MAP Kinase Signaling System; Marine Toxins; Mitogen-Activated Protein Kinases; Nicotiana; Nitriles; Okadaic Acid; Oxazoles; Phosphorylation; Plant Proteins; Plants, Genetically Modified; Seedlings; Temperature | 2007 |
Signalling pathways involved in the control of sperm cell volume.
Topics: Animals; Cell Size; Cells, Cultured; Chloride Channels; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Ion Channels; Male; Maleimides; Marine Toxins; Okadaic Acid; Osmosis; Oxazoles; Papaverine; Phosphoprotein Phosphatases; Protein Kinase C; Signal Transduction; Spermatozoa; Staurosporine; Swine | 2007 |
Apoptosis of human neutrophils induced by protein phosphatase 1/2A inhibition is caspase-independent and serine protease-dependent.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cells, Cultured; Cyclosporine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Marine Toxins; Myeloblastin; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Phosphatase 1; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfones; Time Factors | 2007 |
Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Chlorocebus aethiops; COS Cells; Dimerization; Humans; Marine Toxins; Mice; Molecular Sequence Data; NIH 3T3 Cells; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Receptors, Adrenergic, beta-2; Sequence Homology, Amino Acid; Sodium-Hydrogen Exchangers | 2007 |
Emetine regulates the alternative splicing of Bcl-x through a protein phosphatase 1-dependent mechanism.
Topics: Alternative Splicing; bcl-X Protein; Breast Neoplasms; Cell Line, Tumor; Cycloheximide; Down-Regulation; Emetine; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Marine Toxins; Okadaic Acid; Oxazoles; Prostatic Neoplasms; Protein Phosphatase 1; Protein Phosphatase 2; Up-Regulation; Uterine Cervical Neoplasms | 2007 |
Cellular serine/threonine phosphatase activity during human cytomegalovirus infection.
Topics: Animals; Cells, Cultured; Cytomegalovirus Infections; eIF-2 Kinase; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Humans; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis | 2008 |
Phosphatase inhibition and cell survival after DNA damage induced by radiation.
Topics: Cell Line, Tumor; DNA Damage; DNA, Neoplasm; Humans; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-akt; Radiation Tolerance; RNA, Small Interfering; Signal Transduction; Transfection | 2009 |
Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes.
Topics: Action Potentials; Animals; Cyclosporine; Humans; Indoles; KCNQ Potassium Channels; Maleimides; Marine Toxins; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Potassium Channel Blockers; Protein Kinase C; Pyridines; Xenopus laevis | 2009 |
Complex phosphatase regulation of Ca2+-activated Cl- currents in pulmonary arterial smooth muscle cells.
Topics: Animals; Calcium; Cantharidin; Chlorine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; Lung; Marine Toxins; Myocytes, Smooth Muscle; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Pulmonary Artery; Rabbits | 2009 |
NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.
Topics: Animals; Blotting, Western; Chlorocebus aethiops; COS Cells; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Humans; Kidney Tubules, Proximal; Kinetics; Male; Marine Toxins; Microvilli; Mutation; Nuclear Proteins; Okadaic Acid; Opossums; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Transfection | 2010 |
Inhibition of Ser/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors.
Topics: Aniline Compounds; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Indoles; Male; Marine Toxins; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Nitriles; Okadaic Acid; Oxazoles; Phosphorylation; Protein Serine-Threonine Kinases; Quinolines; Signal Transduction; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; src-Family Kinases; Sulfonamides; Tyrosine | 2010 |
Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1.
Topics: Animals; Carrier Proteins; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; Hippocampus; Humans; Marine Toxins; Membrane Proteins; Neurons; Okadaic Acid; Oxazoles; Protein Phosphatase 1; Rats; Receptors, GABA; Recombinant Fusion Proteins; Synapses | 2010 |
Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Blotting, Western; Caspase 3; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoprecipitation; Jurkat Cells; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Phosphatase 1; Proto-Oncogene Proteins c-akt; Pyrans; Serine; Signal Transduction; Sphingosine; Spiro Compounds | 2011 |
Adrenergic regulation of the distribution of transducer of regulated cAMP-response element-binding protein (TORC2) in rat pinealocytes.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Circadian Rhythm; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Male; Marine Toxins; Norepinephrine; Okadaic Acid; Oxazoles; Phosphorylation; Pineal Gland; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Signal Transduction; Trans-Activators; Transcription Factors | 2011 |
Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Arrestins; beta-Arrestins; Biocatalysis; Cell Membrane; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Rats; Receptors, Somatostatin; Serine; Signal Transduction; Time Factors | 2011 |
Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
Topics: Animals; Blotting, Western; Carrier Proteins; Enzyme Inhibitors; Flow Cytometry; Inflammasomes; Interleukin-1beta; Macrophages, Peritoneal; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Okadaic Acid; Oxazoles; Peritonitis; Phosphoprotein Phosphatases; Random Allocation; Sphingosine | 2012 |
Phosphorylation of AIB1 at mitosis is regulated by CDK1/CYCLIN B.
Topics: Animals; CDC2 Protein Kinase; Cell Line, Tumor; Chlorocebus aethiops; Chromatin; COS Cells; Cyclin A; Cyclin B; E2F1 Transcription Factor; Flow Cytometry; HeLa Cells; Humans; Marine Toxins; Mitosis; Models, Biological; Nuclear Receptor Coactivator 3; Okadaic Acid; Oxazoles; Phosphorylation; Protein Processing, Post-Translational | 2011 |
Auxin activates the plasma membrane H+-ATPase by phosphorylation during hypocotyl elongation in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Membrane; Enzyme Activation; F-Box Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hypocotyl; Indoleacetic Acids; Leupeptins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Proteasome Endopeptidase Complex; Proton-Translocating ATPases; Receptors, Cell Surface; Signal Transduction; Threonine; Time Factors; Transcription, Genetic | 2012 |
Differential effects of phosphatase inhibitors on the calcium homeostasis and migration of HaCaT keratinocytes.
Topics: Calcium Signaling; Cell Line; Cell Movement; Cells, Cultured; Enzyme Inhibitors; Homeostasis; Humans; Keratinocytes; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 2013 |
Inhibition of PP2A activity confers a TRAIL-sensitive phenotype during malignant transformation.
Topics: Antigens, Polyomavirus Transforming; Apoptosis; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Humans; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phenotype; Protein Phosphatase 2; RNA, Small Interfering; Telomerase; TNF-Related Apoptosis-Inducing Ligand | 2014 |
Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
Topics: Animals; Binding Sites; Blotting, Western; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; HEK293 Cells; Hippocampus; Humans; Male; Marine Toxins; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Protein Phosphatase 2; Protein Subunits; Receptors, AMPA; Serine; Threonine | 2014 |
Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.
Topics: Binding Sites; Burkitt Lymphoma; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Marine Toxins; Myeloid Cell Leukemia Sequence 1 Protein; Okadaic Acid; Oxazoles; Phosphorylation; Protein Phosphatase 2; Proteolysis; Serine; Tetradecanoylphorbol Acetate; Threonine | 2014 |
Phosphoproteomic Analysis Using the WW and FHA Domains as Biological Filters.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Cell Extracts; Chromatography, Affinity; Colforsin; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation; HeLa Cells; Humans; Marine Toxins; Molecular Sequence Annotation; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Proteomics; Signal Transduction | 2015 |
Combination of zoledronic acid and serine/threonine phosphatase inhibitors induces synergistic cytotoxicity and apoptosis in human breast cancer cells via inhibition of PI3K/Akt pathway.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Diphosphonates; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Humans; Imidazoles; Marine Toxins; MCF-7 Cells; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Proto-Oncogene Proteins c-akt; Signal Transduction; Zoledronic Acid | 2016 |
Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.
Topics: Anaphase; Anaphase-Promoting Complex-Cyclosome; CDC2 Protein Kinase; Cdc20 Proteins; Chromosomes; Cyclin A; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Gene Expression Regulation; HeLa Cells; Humans; Isoenzymes; M Phase Cell Cycle Checkpoints; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Securin; Signal Transduction; Spindle Apparatus | 2016 |
Ceramide inhibits PKCθ by regulating its phosphorylation and translocation to lipid rafts in Jurkat cells.
Topics: Cell Proliferation; Ceramides; fas Receptor; Humans; Jurkat Cells; Lymphocyte Activation; Marine Toxins; Membrane Microdomains; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C-theta; Protein Transport; Signal Transduction; Sphingomyelin Phosphodiesterase; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2016 |
Selective inhibition of the kinase DYRK1A by targeting its folding process.
Topics: Amino Acid Sequence; Animals; Biological Assay; Biomarkers; Cantharidin; Dyrk Kinases; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphorylation; Plasmids; Protein Folding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Alignment; Thiazoles; Transfection; Xenopus laevis | 2016 |
Standardization of CalyculinA induced PCC assay and its advantages over Okadaic acid PCC assay in Biodosimetry applications.
Topics: Carcinogens; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Lymphocytes; Marine Toxins; Okadaic Acid; Oxazoles; Radiometry | 2016 |
Human cytomegalovirus phosphoproteins are hypophosphorylated and intrinsically disordered.
Topics: Cytomegalovirus; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Viral Matrix Proteins | 2017 |
Cordycepin inhibits migration of human glioblastoma cells by affecting lysosomal degradation and protein phosphatase activation.
Topics: Ammonium Chloride; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Deoxyadenosines; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lysosomes; Marine Toxins; Mice, Nude; Neoplasm Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Proteolysis; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion.
Topics: Alternative Splicing; DNA-Binding Proteins; Exons; HEK293 Cells; HeLa Cells; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Serine; tau Proteins; Up-Regulation | 2018 |
Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish.
Topics: Animals; Apoptosis; Cardiomyopathies; Disease Models, Animal; Enzyme Inhibitors; Humans; Marine Toxins; Myocardial Contraction; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Zebrafish; Zebrafish Proteins | 2018 |
PP1/PP2A phosphatase inhibition-induced metaplasticity in protein synthesis blocker-treated hippocampal slices: LTP and LTD, or There and Back again.
Topics: Animals; Anisomycin; CA1 Region, Hippocampal; Cycloheximide; Electric Stimulation; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Marine Toxins; Neuronal Plasticity; Nitric Oxide; Okadaic Acid; Oxazoles; Protein Phosphatase 1; Protein Phosphatase 2; Protein Synthesis Inhibitors; Rats; Rats, Wistar | 2021 |