oxazoles has been researched along with linezolid in 127 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 38 (29.92) | 18.2507 |
| 2000's | 34 (26.77) | 29.6817 |
| 2010's | 48 (37.80) | 24.3611 |
| 2020's | 7 (5.51) | 2.80 |
| Authors | Studies |
|---|---|
| Barbachyn, MR; Brickner, SJ; Ford, CW; Garmon, SA; Grega, KC; Hendges, SK; Hutchinson, DK; Manninen, PR; Toops, DS; Ulanowicz, DA; Zurenko, GE | 1 |
| Barbachyn, MR; Brickner, SJ; Ford, CW; Hamel, JC; Hutchinson, DK; Moerman, JK; Stapert, D; Wilson, DM; Yancey, RJ | 1 |
| Eliopoulos, GM; Gold, HS; Moellering, RC; Wennersten, CB | 1 |
| Appelbaum, PC; Jacobs, MR; Spangler, SK | 1 |
| Kaplan, SL; Lamberth, LB; Mason, EO | 1 |
| Allison, JW; Barbachyn, MR; Brickner, SJ; Glickman, SE; Hutchinson, DK; Kilburn, JO; Schaadt, RD; Yagi, BH; Zurenko, GE | 1 |
| Erwin, ME; Johnson, DM; Jones, RN | 1 |
| Kaatz, GW; Seo, SM | 1 |
| Drenning, SD; Mulazimoglu, L; Yu, VL | 1 |
| Jorgensen, JH; McElmeel, ML; Trippy, CW | 1 |
| Erwin, ME; Jones, RN; Worth, S | 1 |
| Batts, DH; Daley-Yates, PT; Pawsey, SD; Schaadt, RD; Stalker, DJ; Zurenko, GE | 1 |
| Buysse, JM; Demyan, WF; Dunyak, DS; Lin, AH; Marotti, KR; Melchior, EP; Murray, RW; Shinabarger, DL; Swaney, SM | 1 |
| Biedenbach, DJ; Jones, RN | 1 |
| Aeschlimann, JR; Cappelletty, DM; Kaatz, GW; Moldovan, T; Rybak, MJ | 1 |
| Adamski, JL; Allwine, DA; Barbachyn, MR; Brickner, SJ; Burton, PS; Conradi, RA; Ford, CW; Grega, KC; Hutchinson, DK; Jensen, RM; Klock, JL; Tucker, JA; Zurenko, GE | 1 |
| Aoki, H; Ganoza, MC; Shinabarger, DL; Swaney, SM | 1 |
| Andrews, JM; Ashby, JP; Boswell, FJ; Wise, R | 1 |
| Moellering, RC | 1 |
| Kruzynski, J; Noskin, GA; Peterson, LR; Siddiqui, F; Stosor, V | 1 |
| Chase, S; Cynamon, MH; Klemens, SP; Sharpe, CA | 1 |
| Peters, G; von Eiff, C | 1 |
| Patel, R; Piper, KE; Rouse, MS; Steckelberg, JM | 1 |
| Hamilton-Miller, JM; Shah, S | 1 |
| Barbadora, K; Green, M; Kearney, JA; Mason, EO; Wald, ER | 1 |
| Fresnadillo, MJ; García-Rodríguez, JA; García-Sánchez, E; García-Sánchez, JE; Montes Martínez, I; Trujillano-Martín, I | 1 |
| Hacek, D; Noskin, GA; Peterson, LR; Siddiqui, F; Stosor, V | 1 |
| Hoppe, JE | 1 |
| Sköld, O | 1 |
| Antony, SJ; Bitter, KM; Diaz-Luna, H; Moreland, T; Raudales, F | 1 |
| Kloss, P; Mankin, AS; Shinabarger, DL; Xiong, L | 1 |
| Eliopoulos, GM; Moellering, RC; Schülin, T; Thauvin-Eliopoulos, C | 1 |
| Hopkins, NK; Jungbluth, GL; Sisson, TL | 1 |
| Abdel-Rahman, SM; Kearns, GL | 1 |
| Chien, JW; Kucia, ML; Salata, RA | 1 |
| Johnson, AP; Livermore, DM; Warner, M | 1 |
| Chandrasekar, PH; Clark, NM; Kauffman, CA; McNeil, SA | 1 |
| Albut, R; Figueira, M; Pelton, SI; Stalker, D | 1 |
| Aoyama, H; Aoyama, M; Chiba, K; Igarashi, M; Murata, S; Ozawa, N; Peng, GW; Stryd, RP; Zenki, T | 1 |
| Diekema, DI; Jones, RN | 1 |
| Grucz, RG; Hershberger, E; Moldovan, T; Rybak, MJ | 1 |
| Bowersock, TL; Ford, CW; Portis, ES; Prescott, JF; Robison, DA; Salmon, SA; Watts, JL | 1 |
| MacConnachie, AM | 1 |
| Clemett, D; Markham, A | 1 |
| Lundstrom, TS; Sobel, JD | 1 |
| Fines, M; Leclercq, R | 1 |
| Betriu, C; Boloix, A; Culebras, E; Gómez, M; Palau, ML; Picazo, JJ; Redondo, M; Sánchez, A | 1 |
| Apfalter, P; Hirschl, AM; Makristathis, A; Rotter, ML; Wimmer, M | 1 |
| Hauer, MJ; Wienkers, LC; Wynalda, MA | 1 |
| Flanagan, PG; Penrose-Stevens, A; Pitman, I; Simpson, BA; Tan, TY | 1 |
| Aoki, H; Gadwood, RC; Ganoza, MC; Ke, L; Poel, TJ; Poppe, SM; Shinabarger, DL; Thomas, RC; Weaver, EA | 1 |
| Anderegg, TR; Biedenbach, DJ; Jones, RN | 1 |
| Barbachyn, MR; Ford, CW; Zurenko, GE | 1 |
| Chen, K; Cui, Y; Ji, R; Yang, Y; Zhang, S | 1 |
| Colleran, E; Cormican, M; Curtin, J; Fleming, G; Keelehan, J | 1 |
| Kapadnis, PB; Lohray, BB; Lohray, VB; Pandya, P; Srivastava, BK | 1 |
| Rao, M; Rattan, A; Singhal, S; Sood, R | 1 |
| Arora, SK; Dixit, PP; Jain, S; Nair, PS; Patil, VJ; Sinha, N | 1 |
| Bronson, J; Clark, J; D'Andrea, S; Denbleyker, K; Fung-Tomc, JC; Taylor, D; Yang, H; Zheng, ZB | 1 |
| Gravestock, MB | 1 |
| Brieland, JK; Chosay, JG; Leach, KL; Nagiec, EE; Ross, DE; Swaney, SM; Wu, L | 1 |
| Das, J; Iqbal, J; Khera, MK; Selvakumar, N; Sitaram Kumar, M; Srinivas, D; Sunil Kumar, G; Trehan, S; Yadi Reddy, B | 1 |
| Bansal, V; Das, B; Gupta, JB; Naruganahalli, KS; Ray, A; Shirumalla, RK | 1 |
| Cavazos-Rocha, N; Choi, SH; de Torres, NW; Espinoza-González, NA; Lozano-Garza, G; Ocampo-Candiani, J; Said-Fernandez, S; Vera-Cabrera, L; Welsh, O | 1 |
| Nau, JY | 1 |
| Bhateja, P; Bhatnagar, PK; Fatma, T; Khan, S; Mathur, T; Pandya, M; Rattan, A; Singhal, S; Upadhyay, DJ | 1 |
| Ercan, A; Jayaprakash, V; Sinha, BN; Ucar, G | 1 |
| Kalia, V; Khan, S; Mathur, T; Miglani, R; Purnapatre, KP; Raj, VS; Rattan, A; Saini, KS; Singhal, S; Upadhyay, DJ; Voleti, SR | 1 |
| Drusano, GL; Kulawy, R; Liu, W; Louie, A | 1 |
| Bartizal, K; Bien, P; Deanda, C; Pillar, CM; Prokocimer, P | 1 |
| Bartizal, K; Choi, S; Im, W | 1 |
| Andes, DR; Craig, WA; Lepak, AJ; Marchillo, K; Pichereau, S | 1 |
| Bartizal, K; Fang, E; Flanagan, S; Minassian, SL; Prokocimer, P | 1 |
| Bartizal, K; Locke, JB; Shaw, KJ; Zurenko, GE | 1 |
| Bien, P; De Anda, C; Prokocimer, P | 1 |
| Jeong, BH; Koh, WJ; Kwon, YS | 1 |
| Kotapalli, SS; Naresh, A; Ummanni, R; Venkateswara Rao, B; Venkateswara Rao, M | 1 |
| Corey, GR; Das, AF; De Anda, C; Fang, E; Moran, GJ; Prokocimer, P | 1 |
| Kern, WV; Tacconelli, E | 1 |
| Cao, J; Chen, H; He, W; Hu, D; Li, H; Liu, Y; Ma, X; Wang, H; Wang, Q; Wang, X; Wang, Z; Wu, W; Xia, F; Yang, Q; Zhang, F; Zhang, J; Zhang, R; Zhao, C; Zhao, F | 1 |
| Deane, J; Goering, RV; Jenkins, SG; Locke, JB; Sahm, DF; Scharn, CR; Shaw, KJ; Zuill, DE | 1 |
| Bensaci, M; Bien, P; Patel, HN; Thorne, G; Zurenko, G | 1 |
| Butt, MT; Draganov, D; Hosako, H; Oleson, F; Radovsky, A; Schlosser, MJ; Vija, J | 1 |
| Bartizal, KF; Bien, PA; Deane, J; Locke, JB; Sahm, DF; Shaw, KJ; Zuill, DE | 1 |
| Cox, H; Daniels, C; Furin, J; Lessem, E; McKenna, L; Mitnick, CD; Mosidi, T; Reed, C; Seaworth, B; Stillo, J; Tisile, P; von Delft, D | 1 |
| Burdette, SD; Trotman, R | 1 |
| Choi, S; Hong, SK; Im, W; Lee, K; Lee, Y; Yong, D | 1 |
| Ang, W; Chang, Y; Chen, G; Li, G; Liu, Y; Long, H; Luo, Y; Sang, Z; Tang, J; Wang, Z; Wei, Y; Yang, S; Yang, T; Yang, X; Zhang, J | 1 |
| Chen, KH; Hsueh, PR; Huang, YT; Liao, CH; Sheng, WH | 1 |
| Caminero, JA; Scardigli, A | 1 |
| Douros, A; Grabowski, K; Stahlmann, R | 1 |
| Barber, KE; Raut, A; Rybak, MJ; Smith, JR | 1 |
| Betoudji, F; Converse, PJ; Dartois, V; Li, SY; Mdluli, KE; Mendel, CM; Nuermberger, EL; Tasneen, R; Tyagi, S; Williams, K; Yang, T | 1 |
| Bednarek, E; Cielecka-Piontek, J; Gruba, E; Michalska, K | 1 |
| Greenwood-Quaintance, KE; Patel, R; Silva-Del Toro, SL | 1 |
| Abdelhady, W; Bayer, AS; Gonzales, R; Li, L; Xiong, YQ | 1 |
| Bidell, MR; Flanagan, SD; Lodise, TP; Minassian, SL; Prokocimer, P; Zasowski, EJ | 1 |
| Farrell, DJ; Flamm, RK; Jones, RN; Mendes, RE; Pfaller, MA | 1 |
| Aepfelbacher, M; Belmar Campos, C; Both, A; Büttner, H; Christner, M; Christopeit, M; Klupp, EM; König, C; Rohde, H | 1 |
| Corey, R; Das, AF; De Anda, C; Nathwani, D; Prokocimer, P; Sandison, T | 1 |
| Arber, M; Barata, T; Eales, J; Fleetwood, K; Glanville, J; Gould, IM; Kauf, TL; McCool, R | 1 |
| Brzezinski, A; Milstein, M; Mitnick, CD; Varaine, F | 1 |
| Das, AF; De Anda, C; Fang, E; Prokocimer, P; Sandison, T | 1 |
| Dass, R; Hettle, R; Wirth, D | 1 |
| Asseray, N; Biron, C; Boutoille, D; Gaborit, B; Grégoire, M; Khatchatourian, L; Le Bourgeois, A; Lefebvre, M; Navas, D; Raffi, F | 1 |
| Dong, L; Fu, Y; Huang, H; Huo, F; Jing, W; Li, Y; Ma, Y; Pang, Y; Zhao, L; Zong, Z | 1 |
| Anuskiewicz, S; De Anda, C; Prokocimer, P; Vazquez, J | 1 |
| Anuskiewicz, S; Bidell, M; De Anda, C; Flanagan, S; Hardalo, C; Lodise, TP; Prokocimer, P | 1 |
| Iwamoto, Y; Kato, M; Kohno, S; Mikamo, H; Takesue, Y; Tanigawa, T; Tanimura, Y | 1 |
| Alvarez, DN; Bayer, AS; Farah, S; Garcia-de-la-Maria, C; Miro, JM; Mishra, NN; Sakoulas, G; Zapata, B | 1 |
| Borroni, E; Cirillo, DM; Crook, DW; Cugnata, F; Davies, TJ; Fowler, PW; Gibertoni Cruz, AL; Grazian, C; Hoosdally, SJ; Peto, TEA; Rancoita, PMV; Walker, TM | 1 |
| Choi, H; Kim, KJ; Lee, SH; Yang, JS | 1 |
| Feng, HP; Flanagan, S; Flattery, A; Gill, C; Liang, L; Liu, J; Tan, C; Wu, J; Xiao, J | 1 |
| Ahn, H; Ahn, JH; Cho, SN; Hahn, S; Jang, JY; Jeon, D; Jhun, BW; Jo, KW; Kang, YA; Kim, CK; Kim, DK; Kim, JS; Kim, SY; Kim, YR; Koh, WJ; Lee, JH; Lee, JY; Lee, M; Lee, SH; Lee, T; Mok, J; Park, JS; Shim, TS; Shin, S; Shin, SJ; Song, T; Won, HJ; Yim, JJ | 1 |
| Laughon, BE; Lee, SFK; Lipman, M; McHugh, TD | 1 |
| Dheda, K; Dooley, KE; Furin, J; Gumbo, T; Maartens, G; Murray, M; Nardell, EA; Warren, RM | 1 |
| Farhat, M; Kadura, S; King, N; Köser, CU; Nakhoul, M; Theron, G; Zhu, H | 1 |
| Bax, HI; de Steenwinkel, JEM; Keutzer, L; Pieterman, ED; Simonsson, USH; van den Berg, S; van der Meijden, A; Wang, H; Zimmerman, MD | 1 |
| Broyde, N; Butterton, JR; Croce, M; De Anda, C; Fujimi, S; Kim, JY; Popejoy, MW; Rodriguez Gonzalez, D; Roquilly, A; Wunderink, RG | 1 |
| Acquah, R; Daniels, J; Furin, J; Loveday, M; Mohr-Holland, E; Mudaly, V; Reuter, A | 1 |
| Kase, M; Kitaoka, A; Kobayashi, S; Matsubara, M; Yasu, T | 1 |
| Adenov, M; Adnan, S; Ahmed, S; Bastard, M; Coutisson, S; Danielyan, N; Franke, MF; Hewison, C; Huerga, H; Islam, S; Janmohamed, A; Kamene Kimenye, M; Karakozian, H; Khan, P; Khan, U; Kholikulov, B; Kirakosyan, O; Krisnanda, A; Kumsa, A; Lachenal, N; Leblanc, G; Lecca, L; Mamsa, S; Melikyan, N; Mitnick, CD; Nkuebe, M; Osso, E; Padayachee, S; Rich, ML; Seung, KJ; Thit, P; Varaine, F | 1 |
| Ahmed, S; Bastard, M; Franke, MF; Grium Tefera, D; Hewison, C; Holtzman, D; Huerga, H; Islam, S; Jacques Leblanc, G; Khan, PY; Khan, U; Kumsa, A; Lachenal, N; Leonovich, O; Mamsa, S; Manzur-Ul-Alam, M; Melikyan, N; Mitnick, CD; Myint, Z; Osso, E; Padayachee, S; Rafi Siddiqui, M; Rashitov, M; Rich, ML; Salahuddin, N; Salia, G; Sánchez, E; Serobyan, A; Seung, KJ; Varaine, F; Vetushko, D; Yeghiazaryan, L | 1 |
18 review(s) available for oxazoles and linezolid
| Article | Year |
|---|---|
An update on the oxazolidinone antibiotics.
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Microbial; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 1999 |
Oxazolidinones: a review.
Topics: Acetamides; Animals; Anti-Infective Agents; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 2000 |
New antibiotics for gram positive infections: linezolid and combination quinapristin/dalfopristin.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Drug Prescriptions; Drug Resistance, Microbial; Drug Therapy, Combination; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazoles; Oxazolidinones; Safety; Virginiamycin | 1999 |
Linezolid.
Topics: Acetamides; Animals; Bacteria; Bacterial Infections; Humans; Linezolid; Oxazoles; Oxazolidinones | 2000 |
Antibiotics for gram-positive bacterial infections. Vancomycin, teicoplanin, quinupristin/dalfopristin, and linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Oxazoles; Oxazolidinones; Teicoplanin; Vancomycin; Virginiamycin | 2000 |
The discovery of linezolid, the first oxazolidinone antibacterial agent.
Topics: Acetamides; Anti-Bacterial Agents; Gram-Negative Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Structure-Activity Relationship | 2001 |
Recent developments in the discovery of novel oxazolidinone antibacterials.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Linezolid; Oxazoles; Oxazolidinones | 2005 |
Tedizolid for the management of human infections: in vitro characteristics.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gene Transfer, Horizontal; Humans; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Point Mutation; Ribosomal Protein L3; Ribosomal Proteins; RNA, Ribosomal, 23S; Staphylococcal Infections; Staphylococcus aureus; tRNA Methyltransferases | 2014 |
Tuberculosis: clinical trials and new drug regimens.
Topics: Acetamides; Adamantane; Antitubercular Agents; Clinical Trials as Topic; Diarylquinolines; Drug Administration Schedule; Drug Design; Ethylenediamines; Female; Fluoroquinolones; Humans; Levofloxacin; Linezolid; Male; Moxifloxacin; Nitroimidazoles; Oxazoles; Oxazolidinones; Spiro Compounds; Thiazines; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2014 |
Access to new medications for the treatment of drug-resistant tuberculosis: patient, provider and community perspectives.
Topics: Antitubercular Agents; Compassionate Use Trials; Diarylquinolines; Health Services Accessibility; Humans; Linezolid; Nitroimidazoles; Oxazoles; Tuberculosis, Multidrug-Resistant; Vulnerable Populations | 2015 |
Tedizolid: The First Once-Daily Oxazolidinone Class Antibiotic.
Topics: Anti-Bacterial Agents; Clinical Trials, Phase III as Topic; Drug Interactions; Drug Resistance, Bacterial; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Staphylococcal Skin Infections | 2015 |
Drug-drug interactions and safety of linezolid, tedizolid, and other oxazolidinones.
Topics: Animals; Anti-Bacterial Agents; Drug Interactions; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Structure-Activity Relationship | 2015 |
Systematic review and network meta-analysis of tedizolid for the treatment of acute bacterial skin and skin structure infections caused by MRSA.
Topics: Anti-Bacterial Agents; Bayes Theorem; Ceftaroline; Cephalosporins; Daptomycin; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Staphylococcal Infections; Tetrazoles; Vancomycin | 2017 |
(Re)moving the needle: prospects for all-oral treatment for multidrug-resistant tuberculosis.
Topics: Administration, Oral; Antitubercular Agents; Clinical Trials, Phase III as Topic; Diarylquinolines; Evidence-Based Medicine; Humans; Linezolid; Needles; Nitroimidazoles; Oxazoles; Randomized Controlled Trials as Topic; Tuberculosis, Multidrug-Resistant | 2016 |
Clinical safety and tolerability of tedizolid phosphate in the treatment of acute bacterial skin and skin structure infections.
Topics: Acute Disease; Administration, Intravenous; Administration, Oral; Anti-Bacterial Agents; Clinical Trials as Topic; Humans; Linezolid; Organophosphates; Oxazoles; Severity of Illness Index; Skin Diseases, Bacterial | 2018 |
New drugs to treat difficult tuberculous and nontuberculous mycobacterial pulmonary disease.
Topics: Amikacin; Anti-Bacterial Agents; Clofazimine; Diarylquinolines; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Liposomes; Lung Diseases; Microbial Sensitivity Tests; Mycobacterium Infections, Nontuberculous; Nitroimidazoles; Oxazoles | 2019 |
The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis.
Topics: Antitubercular Agents; Diarylquinolines; Drug Therapy, Combination; Humans; Linezolid; Nitroimidazoles; Oxazoles; Periodicals as Topic; Pulmonary Medicine; Societies, Medical; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2019 |
Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.
Topics: Antitubercular Agents; Clofazimine; Diarylquinolines; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Pharmaceutical Preparations; Tuberculosis, Multidrug-Resistant | 2020 |
13 trial(s) available for oxazoles and linezolid
| Article | Year |
|---|---|
Serum inhibitory titers and serum bactericidal titers for human subjects receiving multiple doses of the antibacterial oxazolidinones eperezolid and linezolid.
Topics: Acetamides; Administration, Oral; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Enterococcus faecalis; Gram-Positive Bacterial Infections; Humans; Injections, Intravenous; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae | 1997 |
A pharmacokinetic evaluation of concomitant administration of linezolid and aztreonam.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Aztreonam; Cross-Over Studies; Drug Interactions; Female; Humans; Linezolid; Male; Middle Aged; Monobactams; Oxazoles; Oxazolidinones | 1999 |
Use of linezolid, an oxazolidinone, in the treatment of multidrug-resistant gram-positive bacterial infections.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Anti-Infective Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Enterococcus; Epidural Abscess; Female; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Male; Methicillin Resistance; Microbial Sensitivity Tests; Middle Aged; Oxazoles; Oxazolidinones; Parotitis; Staphylococcal Infections; Staphylococcus aureus; Vancomycin Resistance | 2000 |
In vitro activity and microbiological efficacy of tedizolid (TR-700) against Gram-positive clinical isolates from a phase 2 study of oral tedizolid phosphate (TR-701) in patients with complicated skin and skin structure infections.
Topics: Acetamides; Adolescent; Adult; Aged; Anti-Bacterial Agents; Culture Media; Double-Blind Method; Drug Administration Schedule; Female; Humans; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Organophosphates; Oxazoles; Oxazolidinones; Skin; Staphylococcal Skin Infections; Staphylococcus; Tetrazoles | 2012 |
In vitro, in vivo, and clinical studies of tedizolid to assess the potential for peripheral or central monoamine oxidase interactions.
Topics: Acetamides; Adolescent; Adult; Aged; Animals; Anti-Bacterial Agents; Blood Pressure; Female; Humans; Linezolid; Male; Mice; Middle Aged; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Organophosphates; Oxazoles; Oxazolidinones; Pseudoephedrine; Serotonin; Serotonin Agents; Tetrazoles; Tyramine; Young Adult | 2013 |
Comparison of digital planimetry and ruler technique to measure ABSSSI lesion sizes in the ESTABLISH-1 study.
Topics: Acetamides; Anti-Bacterial Agents; Erythema; Humans; Image Interpretation, Computer-Assisted; Linezolid; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; United States | 2014 |
Tedizolid for 6 days versus linezolid for 10 days for acute bacterial skin and skin-structure infections (ESTABLISH-2): a randomised, double-blind, phase 3, non-inferiority trial.
Topics: Acetamides; Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Double-Blind Method; Female; Humans; Linezolid; Male; Middle Aged; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Treatment Outcome; Young Adult | 2014 |
Characterization of the haematological profile of 21 days of tedizolid in healthy subjects.
Topics: Adult; Anti-Bacterial Agents; Blood Cells; Double-Blind Method; Female; Healthy Volunteers; Humans; Linezolid; Male; Middle Aged; Organophosphates; Oxazoles; Placebos; Retrospective Studies; Young Adult | 2016 |
Clinical Response of Tedizolid versus Linezolid in Acute Bacterial Skin and Skin Structure Infections by Severity Measure Using a Pooled Analysis from Two Phase 3 Double-Blind Trials.
Topics: Adolescent; Adult; Anti-Bacterial Agents; Double-Blind Method; Humans; Linezolid; Organophosphates; Oxazoles; Skin; Skin Diseases, Bacterial; Staphylococcal Skin Infections; Staphylococcus aureus; Streptococcal Infections; Streptococcus pyogenes; Young Adult | 2017 |
Outpatient treatment of acute bacterial skin and skin structure infections (ABSSSI) with tedizolid phosphate and linezolid in patients in the United States: Subgroup analysis of 2 randomized phase 3 trials.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Ambulatory Care; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Middle Aged; Organophosphates; Oxazoles; Skin Diseases, Bacterial; Treatment Outcome; United States; Young Adult | 2017 |
Efficacy, safety and pharmacokinetics of tedizolid versus linezolid in patients with skin and soft tissue infections in Japan - Results of a randomised, multicentre phase 3 study.
Topics: Aged; Anti-Bacterial Agents; Bacteremia; Female; Humans; Japan; Linezolid; Male; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Prospective Studies; Skin Diseases, Bacterial; Soft Tissue Infections; Treatment Outcome | 2018 |
Delamanid, linezolid, levofloxacin, and pyrazinamide for the treatment of patients with fluoroquinolone-sensitive multidrug-resistant tuberculosis (Treatment Shortening of MDR-TB Using Existing and New Drugs, MDR-END): study protocol for a phase II/III, m
Topics: Adult; Aged; Aged, 80 and over; Antitubercular Agents; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination; Equivalence Trials as Topic; Female; Humans; Levofloxacin; Linezolid; Male; Middle Aged; Multicenter Studies as Topic; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Pyrazinamide; Republic of Korea; Time Factors; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Young Adult | 2019 |
A Phase 3, Randomized, Double-Blind Study Comparing Tedizolid Phosphate and Linezolid for Treatment of Ventilated Gram-Positive Hospital-Acquired or Ventilator-Associated Bacterial Pneumonia.
Topics: Anti-Bacterial Agents; Double-Blind Method; Hospitals; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Organophosphates; Oxazoles; Pneumonia, Bacterial; Skin Diseases, Bacterial; Ventilators, Mechanical | 2021 |
96 other study(ies) available for oxazoles and linezolid
| Article | Year |
|---|---|
Synthesis and antibacterial activity of U-100592 and U-100766, two oxazolidinone antibacterial agents for the potential treatment of multidrug-resistant gram-positive bacterial infections.
Topics: Acetamides; Animals; Anti-Infective Agents; Dogs; Drug Resistance, Microbial; Drug Resistance, Multiple; Female; Linezolid; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Rats | 1996 |
In vivo activities of U-100592 and U-100766, novel oxazolidinone antimicrobial agents, against experimental bacterial infections.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Bacterial Infections; Drug Therapy, Combination; Female; Gram-Negative Bacteria; Gram-Positive Bacteria; Injections, Intravenous; Injections, Subcutaneous; Linezolid; Methicillin Resistance; Mice; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus aureus; Vancomycin | 1996 |
In vitro activities in new oxazolidinone antimicrobial agents against enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 1996 |
Activities of RPR 106972 (a new oral streptogramin), cefditoren (a new oral cephalosporin), two new oxazolidinones (U-100592 and U-100766), and other oral and parenteral agents against 203 penicillin-susceptible and -resistant pneumococci.
Topics: Acetamides; Amino Acid Sequence; Anti-Bacterial Agents; Cephalosporins; Linezolid; Microbial Sensitivity Tests; Molecular Sequence Data; Oxazoles; Oxazolidinones; Penicillin Resistance; Streptococcus pneumoniae; Virginiamycin | 1996 |
In vitro activities of oxazolidinones U-100592 and U-100766 against penicillin-resistant and cephalosporin-resistant strains of Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; beta-Lactam Resistance; Ceftriaxone; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Penicillins; Streptococcus pneumoniae | 1996 |
In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Drug Resistance, Microbial; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Vancomycin | 1996 |
In vitro antimicrobial activities and spectra of U-100592 and U-100766, two novel fluorinated oxazolidinones.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacteria, Anaerobic; Diffusion; Gram-Negative Bacteria; Gram-Positive Cocci; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 1996 |
In vitro activities of oxazolidinone compounds U100592 and U100766 against Staphylococcus aureus and Staphylococcus epidermidis.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Nafcillin; Oxazoles; Oxazolidinones; Penicillins; Staphylococcus aureus; Staphylococcus epidermidis; Time Factors; Vancomycin | 1996 |
In vitro activities of two novel oxazolidinones (U100592 and U100766), a new fluoroquinolone (trovafloxacin), and dalfopristin-quinupristin against Staphylococcus aureus and Staphylococcus epidermidis.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Synergism; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Naphthyridines; Oxazoles; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus; Staphylococcus epidermidis; Time Factors; Virginiamycin | 1996 |
In vitro activities of the oxazolidinone antibiotics U-100592 and U-100766 against Staphylococcus aureus and coagulase-negative Staphylococcus species.
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Colony Count, Microbial; Linezolid; Oxazoles; Oxazolidinones; Staphylococcus; Staphylococcus aureus | 1997 |
Quality control guidelines for amoxicillin, amoxicillin-clavulanate, azithromycin, piperacillin-tazobactam, roxithromycin, ticarcillin, ticarcillin-clavulanate, trovafloxacin (CP 99,219), U-100592, and U-100766 for various National Committee for Clinical
Topics: Acetamides; Amoxicillin; Amoxicillin-Potassium Clavulanate Combination; Anti-Infective Agents; Azithromycin; Clavulanic Acids; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Naphthyridines; Oxazoles; Oxazolidinones; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Quality Control; Roxithromycin; Ticarcillin | 1996 |
Mechanism of action of oxazolidinones: effects of linezolid and eperezolid on translation reactions.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Bacterial Proteins; Coliphages; Culture Media; Escherichia coli; Linezolid; Microbial Sensitivity Tests; N-Formylmethionine; Oxazoles; Oxazolidinones; Poly U; Polyribosomes; Protein Biosynthesis; Ribosomes; Transcription, Genetic | 1997 |
Disk diffusion test interpretive criteria and quality control recommendations for testing linezolid (U-100766) and eperezolid (U-100592) with commercially prepared reagents.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Evaluation Studies as Topic; Gram-Negative Bacteria; Gram-Positive Bacteria; Humans; Indicators and Reagents; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Quality Control | 1997 |
Comparative in vitro activities and postantibiotic effects of the oxazolidinone compounds eperezolid (PNU-100592) and linezolid (PNU-100766) versus vancomycin against Staphylococcus aureus, coagulase-negative staphylococci, Enterococcus faecalis, and Ente
Topics: Acetamides; Anti-Bacterial Agents; Coagulase; Enterococcus faecalis; Enterococcus faecium; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus aureus; Vancomycin | 1998 |
Piperazinyl oxazolidinone antibacterial agents containing a pyridine, diazene, or triazene heteroaromatic ring.
Topics: Acetamides; Anti-Bacterial Agents; Caco-2 Cells; Enterococcus faecalis; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Permeability; Piperazines; Pyridines; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Structure-Activity Relationship; Triazenes | 1998 |
The oxazolidinone linezolid inhibits initiation of protein synthesis in bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria; Bacterial Proteins; Escherichia coli; Linezolid; Oxazoles; Oxazolidinones; Peptide Initiation Factors; Protein Synthesis Inhibitors; Ribosomes; RNA, Bacterial; RNA, Messenger; RNA, Transfer, Met; Staphylococcus aureus | 1998 |
The in-vitro activity of linezolid (U-100766) and tentative breakpoints.
Topics: Acetamides; Anti-Bacterial Agents; Bacteria, Anaerobic; Bacteroides fragilis; Bacteroides Infections; Colony Count, Microbial; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Time Factors | 1998 |
A novel antimicrobial agent joins the battle against resistant bacteria.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Drug Resistance, Microbial; Humans; Linezolid; Oxazoles; Oxazolidinones | 1999 |
Successful treatment of persistent vancomycin-resistant Enterococcus faecium bacteremia with linezolid and gentamicin.
Topics: Acetamides; Adult; Anti-Bacterial Agents; Bacteremia; Drug Resistance, Microbial; Drug Therapy, Combination; Enterococcus faecium; Female; Gentamicins; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Vancomycin | 1999 |
Activities of several novel oxazolidinones against Mycobacterium tuberculosis in a murine model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Antitubercular Agents; Female; Linezolid; Mice; Mycobacterium tuberculosis; Oxazoles; Oxazolidinones; Tuberculosis | 1999 |
Comparative in-vitro activities of moxifloxacin, trovafloxacin, quinupristin/dalfopristin and linezolid against staphylococci.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Fluoroquinolones; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Oxazoles; Oxazolidinones; Quinolines; Staphylococcal Infections; Staphylococcus; Virginiamycin | 1999 |
In vitro activity of linezolid against vancomycin-resistant enterococci, methicillin-resistant Staphylococcus aureus and penicillin-resistant Streptococcus pneumoniae.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin Resistance; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Penicillin Resistance; Pneumococcal Infections; Staphylococcal Infections; Staphylococcus aureus; Streptococcus pneumoniae; Vancomycin | 1999 |
Susceptibility testing of linezolid by two standard methods.
Topics: Acetamides; Anti-Bacterial Agents; Enterococcus faecalis; Enterococcus faecium; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Sensitivity and Specificity; Staphylococcus aureus; Streptococcus pneumoniae; Streptococcus pyogenes | 1999 |
In vitro activities of the oxazolidinone compounds linezolid (PNU-100766) and eperzolid (PNU-100592) against middle ear isolates of Streptococcus pneumoniae.
Topics: Acetamides; Acute Disease; Anti-Bacterial Agents; Child; Clindamycin; Drug Resistance, Microbial; Erythromycin; Humans; Linezolid; Microbial Sensitivity Tests; Otitis Media; Oxazoles; Oxazolidinones; Penicillins; Pneumococcal Infections; Streptococcus pneumoniae | 1999 |
In vitro activities of five new antimicrobial agents against Brucella melitensis.
Topics: Acetamides; Anti-Bacterial Agents; Brucella melitensis; Humans; Linezolid; Microbial Sensitivity Tests; Mupirocin; Oxazoles; Oxazolidinones; Rifabutin; Virginiamycin | 1999 |
In vitro activities of linezolid against important gram-positive bacterial pathogens including vancomycin-resistant enterococci.
Topics: Acetamides; Anti-Bacterial Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Enterococcus; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus; Streptococcus; Teicoplanin; Vancomycin | 1999 |
In vitro susceptibilities of Bordetella pertussis and Bordetella parapertussis to the novel oxazolidinones eperezolid (PNU-100592) and linezolid (PNU-100766)
Topics: Acetamides; Anti-Bacterial Agents; Bordetella; Bordetella pertussis; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 1999 |
[A new antibacterial agent can stop resistance development. Expectations are connected to linezolid, an oxazolidinone with a new pharmacological action].
Topics: Acetamides; Anti-Infective Agents; Drug Resistance, Microbial; Humans; Linezolid; Oxazoles; Oxazolidinones | 1999 |
Methicillin-resistant Staphylococcus aureus infection in a renal allograft recipient treated successfully with a novel new antimicrobial agent (linezolid): new treatment options for infections due to resistant organisms.
Topics: Acetamides; Adult; Anti-Infective Agents; Drug Resistance, Microbial; Humans; Kidney Transplantation; Linezolid; Male; Methicillin Resistance; Oxazoles; Oxazolidinones; Staphylococcal Infections; Transplantation, Homologous | 1999 |
Resistance mutations in 23 S rRNA identify the site of action of the protein synthesis inhibitor linezolid in the ribosomal peptidyl transferase center.
Topics: Acetamides; Binding Sites; Drug Resistance, Microbial; Halobacterium salinarum; Linezolid; Mutation; Nucleic Acid Conformation; Oxazoles; Oxazolidinones; Peptide Chain Initiation, Translational; Peptidyl Transferases; Protein Synthesis Inhibitors; Ribosomes; RNA, Ribosomal, 23S; RNA, Transfer, Met | 1999 |
Activities of the oxazolidinones linezolid and eperezolid in experimental intra-abdominal abscess due to Enterococcus faecalis or vancomycin-resistant Enterococcus faecium.
Topics: Abdominal Abscess; Acetamides; Animals; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Linezolid; Male; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Rats; Rats, Sprague-Dawley; Treatment Outcome; Vancomycin | 1999 |
[Antibiosis. Therapeutic strategies in intensive care].
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Critical Care; Drug Therapy; Gram-Positive Bacterial Infections; Humans; Linezolid; Needs Assessment; Oxazoles; Oxazolidinones | 1999 |
Activity of linezolid against multi-resistant gram-positive bacteria from diverse hospitals in the United Kingdom.
Topics: Acetamides; Anti-Bacterial Agents; Cross Infection; Drug Resistance, Multiple; Enterococcus; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus; Streptococcus; Streptococcus pneumoniae; United Kingdom | 2000 |
Successful treatment of vancomycin-resistant Enterococcus faecium bacteremia with linezolid after failure of treatment with synercid (quinupristin/dalfopristin).
Topics: Acetamides; Anti-Bacterial Agents; Bacteremia; Bone Marrow Transplantation; Drug Administration Schedule; Drug Therapy, Combination; Enterococcus faecium; Follow-Up Studies; Gram-Positive Bacterial Infections; Humans; Leukemia, Myeloid, Acute; Linezolid; Male; Middle Aged; Oxazoles; Oxazolidinones; Postoperative Complications; Treatment Failure; Treatment Outcome; Vancomycin Resistance; Virginiamycin | 2000 |
Efficacy of linezolid in experimental otitis media.
Topics: Acetamides; Amoxicillin; Animals; Anti-Bacterial Agents; Chinchilla; Disease Models, Animal; Drug Resistance, Microbial; Drug Resistance, Multiple; Haemophilus Infections; Haemophilus influenzae; Humans; Linezolid; Otitis Media; Oxazoles; Oxazolidinones; Pneumococcal Infections; Streptococcus pneumoniae | 2000 |
Determination of linezolid in plasma by reversed-phase high-performance liquid chromatography.
Topics: Acetamides; Animals; Anti-Infective Agents; Calibration; Chromatography, High Pressure Liquid; Dogs; Indicators and Reagents; Linezolid; Mice; Oxazoles; Oxazolidinones; Quality Control; Rabbits; Rats; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet | 1999 |
In vitro activities of daptomycin, vancomycin, linezolid, and quinupristin-dalfopristin against Staphylococci and Enterococci, including vancomycin- intermediate and -resistant strains.
Topics: Acetamides; Anti-Bacterial Agents; Daptomycin; Drug Resistance, Multiple; Enterococcus; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcus; Time Factors; Vancomycin; Virginiamycin | 2000 |
MICs of oxazolidinones for Rhodococcus equi strains isolated from humans and animals.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Horses; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Rhodococcus equi | 2000 |
Activity of linezolid against Gram-positive cocci possessing genes conferring resistance to protein synthesis inhibitors.
Topics: Acetamides; Drug Resistance, Microbial; Gram-Positive Cocci; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Protein Synthesis Inhibitors; Ribosomes | 2000 |
Comparative in vitro activities of linezolid, quinupristin-dalfopristin, moxifloxacin, and trovafloxacin against erythromycin-susceptible and -resistant streptococci.
Topics: Acetamides; Anti-Bacterial Agents; Aza Compounds; Drug Resistance, Microbial; Drug Therapy, Combination; Erythromycin; Fluoroquinolones; Humans; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Naphthyridines; Oxazoles; Oxazolidinones; Quinolines; Streptococcus; Virginiamycin | 2000 |
In vitro activities of linezolid alone and in combination with amoxicillin, clarithromycin, and metronidazole against Helicobacter pylori.
Topics: Acetamides; Amoxicillin; Anti-Bacterial Agents; Clarithromycin; Drug Synergism; Drug Therapy, Combination; Helicobacter pylori; Humans; Linezolid; Metronidazole; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Penicillins | 2000 |
Linezolid (Zyvox).
Topics: Acetamides; Administration, Oral; Anti-Infective Agents; Controlled Clinical Trials as Topic; Costs and Cost Analysis; Dose-Response Relationship, Drug; Drug Interactions; Humans; Infusions, Parenteral; Linezolid; Oxazoles; Oxazolidinones; Protein Synthesis Inhibitors | 2000 |
Linezolid approval brings new treatment option for resistant bacteria.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Infections; Drug Interactions; Drug Resistance, Microbial; Humans; Linezolid; Oxazoles; Oxazolidinones | 2000 |
Oxidation of the novel oxazolidinone antibiotic linezolid in human liver microsomes.
Topics: Acetamides; Animals; Anti-Infective Agents; Carbon Radioisotopes; Cell Line; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Humans; Linezolid; Mass Spectrometry; Microsomes; Microsomes, Liver; Oxazoles; Oxazolidinones; Oxidation-Reduction | 2000 |
Treatment of a vancomycin-resistant Enterococcus faecium ventricular drain infection with quinupristin/dalfopristin and review of the literature.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Drug Resistance, Multiple; Drug Therapy, Combination; Enterococcus faecium; Fatal Outcome; Female; Gram-Positive Bacterial Infections; Humans; Hydrocephalus; Injections, Intravenous; Injections, Intraventricular; Injections, Spinal; Linezolid; Middle Aged; Oxazoles; Oxazolidinones; Subarachnoid Hemorrhage; Tomography, X-Ray Computed; Vancomycin; Ventriculoperitoneal Shunt; Virginiamycin | 2000 |
Antibiotic available for compassionate use.
Topics: Acetamides; AIDS-Related Opportunistic Infections; Anti-Infective Agents; Hotlines; Humans; Linezolid; Methicillin Resistance; Oxazoles; Oxazolidinones; Staphylococcal Infections | 1998 |
Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Bacterial Translocation; Escherichia coli; Kinetics; Linezolid; Oxazoles; Oxazolidinones; Peptide Chain Initiation, Translational; Peptide Elongation Factor G; Peptide Elongation Factors; Peptidyl Transferases; Protein Biosynthesis; Ribosomes; RNA, Transfer, Met | 2002 |
In vitro evaluation of AZD2563, a novel oxazolidinone, against 603 recent staphylococcal isolates.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Humans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Staphylococcal Infections; Staphylococcus aureus | 2002 |
Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group.
Topics: Acetamides; Anti-Infective Agents; Bacteria; Chemical Phenomena; Chemistry, Physical; Gram-Positive Bacteria; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Structure-Activity Relationship; Sulfonamides | 2003 |
Linezolid compared with eperezolid, vancomycin, and gentamicin in an in vitro model of antimicrobial lock therapy for Staphylococcus epidermidis central venous catheter-related biofilm infections.
Topics: Acetamides; Anti-Infective Agents; Biofilms; Catheterization, Central Venous; Catheters, Indwelling; Colony Count, Microbial; Gentamicins; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Sodium Chloride; Staphylococcal Infections; Staphylococcus epidermidis; Vancomycin | 2003 |
Novel tetrahydro-thieno pyridyl oxazolidinone: an antibacterial agent.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Microbial; Enterococcus faecalis; Linezolid; Methicillin; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Pyridines; Staphylococcus aureus; Structure-Activity Relationship; Vancomycin | 2004 |
Activity of RBx 7644 and RBx 8700, new investigational oxazolidinones, against Mycobacterium tuberculosis infected murine macrophages.
Topics: Acetamides; Animals; Antitubercular Agents; Cell Line; Drug Antagonism; Furans; Isoniazid; Linezolid; Macrophages; Mice; Microbial Sensitivity Tests; Molecular Structure; Mycobacterium tuberculosis; Oxazoles; Oxazolidinones; Rifampin | 2005 |
Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives.
Topics: Acetamides; Anti-Bacterial Agents; Drug Resistance, Bacterial; Gram-Negative Bacteria; Gram-Positive Bacteria; In Vitro Techniques; Linezolid; Methicillin; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Structure-Activity Relationship; Vancomycin | 2005 |
Synthesis and antibacterial activity of dihydro-1,2-oxazine and 2-pyrazoline oxazolidinones: novel analogs of linezolid.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Gram-Positive Bacteria; Linezolid; Mice; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones | 2005 |
Oxazolidinones inhibit cellular proliferation via inhibition of mitochondrial protein synthesis.
Topics: Acetamides; Animals; Blotting, Western; Cell Proliferation; Cells, Cultured; Flow Cytometry; Humans; In Vitro Techniques; K562 Cells; Linezolid; Mitochondria, Heart; Oxazoles; Oxazolidinones; Protein Synthesis Inhibitors; Rats; Structure-Activity Relationship | 2005 |
Synthesis of novel tricyclic oxazolidinones by a tandem SN2 and SNAr reaction: SAR studies on conformationally constrained analogues of Linezolid.
Topics: Acetamides; Anti-Bacterial Agents; Anti-Infective Agents; Chemistry, Pharmaceutical; Drug Design; Drug Resistance, Bacterial; Drug Resistance, Microbial; Fluorine; Linezolid; Microbial Sensitivity Tests; Models, Chemical; Molecular Conformation; Oxazoles; Oxazolidinones; Structure-Activity Relationship | 2006 |
Ranbezolid, a novel oxazolidinone antibacterial: in vivo characterisation of monoamine oxidase inhibitory potential in conscious rats.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Blood Pressure; Clorgyline; Dose-Response Relationship, Drug; Furans; Linezolid; Male; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Rats; Rats, Wistar | 2006 |
Efficacy of DA-7218, a new oxazolidinone prodrug, in the treatment of experimental actinomycetoma produced by Nocardia brasiliensis.
Topics: Acetamides; Actinomycosis; Animals; Disease Models, Animal; Linezolid; Mice; Mice, Inbred BALB C; Mycetoma; Nocardia; Nocardia Infections; Organophosphates; Oxazoles; Oxazolidinones; Prodrugs; Tetrazoles; Treatment Outcome | 2008 |
[Some new antitubercular agents].
Topics: Acetamides; Antitubercular Agents; Diarylquinolines; Humans; Linezolid; Nitroimidazoles; Oxazoles; Oxazolidinones; Quinolines | 2008 |
Effect of oxazolidinone, RBx 7644 (ranbezolid), on inhibition of staphylococcal adherence to plastic surfaces.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Adhesion; Biofilms; Dose-Response Relationship, Drug; Furans; Linezolid; Microbial Sensitivity Tests; Oxazoles; Oxazolidinones; Plastics; Staphylococcus aureus; Staphylococcus epidermidis; Time Factors; Vancomycin; Virginiamycin | 2008 |
Pyrazoline-based mycobactin analogues as MAO-inhibitors.
Topics: Acetamides; Animals; Binding Sites; Catalytic Domain; Drug Design; Humans; Inhibitory Concentration 50; Linezolid; Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Oxazoles; Oxazolidinones; Pyrazoles; Rats; Siderophores | 2008 |
Mode of action of Ranbezolid against staphylococci and structural modeling studies of its interaction with ribosomes.
Topics: Acetamides; Anti-Bacterial Agents; Cell Membrane Permeability; Furans; Linezolid; Oxazoles; Oxazolidinones; Protein Biosynthesis; Protein Synthesis Inhibitors; Ribosomes; Staphylococcus aureus; Staphylococcus epidermidis; Transcription, Genetic | 2009 |
In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection model.
Topics: Acetamides; Animals; Anti-Bacterial Agents; Female; Humans; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones; Serum; Staphylococcal Infections; Staphylococcus aureus; Tetrazoles; Thigh | 2011 |
Activity of tedizolid phosphate (TR-701) in murine models of infection with penicillin-resistant and penicillin-sensitive Streptococcus pneumoniae.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Culture Media; Drug Administration Schedule; Female; Linezolid; Lung; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Microbial Sensitivity Tests; Models, Animal; Organophosphates; Oxazoles; Oxazolidinones; Penicillin Resistance; Penicillins; Pneumonia, Pneumococcal; Streptococcus pneumoniae; Survival Rate | 2012 |
Comparative pharmacodynamics of the new oxazolidinone tedizolid phosphate and linezolid in a neutropenic murine Staphylococcus aureus pneumonia model.
Topics: Acetamides; Administration, Oral; Animals; Anti-Bacterial Agents; Area Under Curve; Blood Proteins; Colony Count, Microbial; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Linezolid; Lung; Methicillin-Resistant Staphylococcus aureus; Mice; Mice, Inbred ICR; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Oxazolidinones; Pneumonia, Staphylococcal; Prodrugs; Protein Binding; Staphylococcus aureus | 2012 |
Oxazolidinone derivatives: cytoxazone-linezolid hybrids induces apoptosis and senescence in DU145 prostate cancer cells.
Topics: Acetamides; Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cellular Senescence; Humans; Linezolid; Male; Membrane Potential, Mitochondrial; Oxazoles; Oxazolidinones; Prostatic Neoplasms | 2014 |
New antibiotics for skin and skin-structure infections.
Topics: Acetamides; Anti-Bacterial Agents; Female; Humans; Linezolid; Male; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial | 2014 |
In vitro antimicrobial activity of the novel oxazolidinone tedizolid and comparator agents against Staphylococcus aureus and linezolid-resistant Gram-positive pathogens: a multicentre study in China.
Topics: Acetamides; China; Drug Resistance, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones; Staphylococcus aureus | 2014 |
Identification and characterization of linezolid-resistant cfr-positive Staphylococcus aureus USA300 isolates from a New York City medical center.
Topics: Acetamides; Anti-Bacterial Agents; Bacterial Proteins; Clindamycin; Diterpenes; Drug Resistance, Multiple, Bacterial; Gene Transfer Techniques; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Molecular Sequence Data; New York; Organophosphates; Oxazoles; Oxazolidinones; Plasmids; Staphylococcal Infections; Thiamphenicol | 2014 |
Use of linezolid susceptibility test results as a surrogate for the susceptibility of Gram-positive pathogens to tedizolid, a novel oxazolidinone.
Topics: Acetamides; Anti-Bacterial Agents; Biomarkers; Diagnostic Errors; Gram-Positive Bacteria; Humans; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Oxazolidinones | 2014 |
Lack of neuropathological changes in rats administered tedizolid phosphate for nine months.
Topics: Animals; Anti-Bacterial Agents; Female; Linezolid; Male; Neurotoxicity Syndromes; Organophosphates; Oxazoles; Rats; Rats, Inbred LEC | 2015 |
Results of the surveillance of Tedizolid activity and resistance program: in vitro susceptibility of gram-positive pathogens collected in 2011 and 2012 from the United States and Europe.
Topics: Acetamides; Anti-Bacterial Agents; Epidemiological Monitoring; Europe; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Organophosphates; Oxazoles; Oxazolidinones; Ribosomal Proteins; RNA, Ribosomal, 23S; United States | 2015 |
In vitro activity of tedizolid against gram-positive bacteria in patients with skin and skin structure infections and hospital-acquired pneumonia: a Korean multicenter study.
Topics: Anti-Bacterial Agents; Asian People; Gram-Positive Bacteria; Gram-Positive Bacterial Infections; Hospitals; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Pneumonia; Republic of Korea; Skin; Skin Diseases | 2015 |
Discovery of a Teraryl Oxazolidinone Compound (S)-N-((3-(3-Fluoro-4-(4-(pyridin-2-yl)-1H-pyrazol-1-yl)phenyl)-2-oxooxazolidin-5-yl)methyl)acetamide Phosphate as a Novel Antimicrobial Agent with Enhanced Safety Profile and Efficacies.
Topics: Acetamides; Animals; Anti-Infective Agents; Bacteria; Biological Availability; Drug Design; Ether-A-Go-Go Potassium Channels; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Models, Molecular; Oxazoles; Oxazolidinones; Potassium Channel Blockers; Staphylococcal Infections; Structure-Activity Relationship; Tetrazolium Salts; Thiazoles | 2015 |
In Vitro Activities of Tedizolid and Linezolid against Gram-Positive Cocci Associated with Acute Bacterial Skin and Skin Structure Infections and Pneumonia.
Topics: Acute Disease; Anti-Bacterial Agents; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Pneumonia, Bacterial; Staphylococcal Skin Infections; Streptococcal Infections; Streptococcus agalactiae; Streptococcus anginosus; Streptococcus pyogenes; Taiwan; Vancomycin-Resistant Enterococci | 2015 |
Classification of antituberculosis drugs: a new proposal based on the most recent evidence.
Topics: Antitubercular Agents; Carbapenems; Clavulanic Acid; Clofazimine; Diarylquinolines; Drug Therapy, Combination; Extensively Drug-Resistant Tuberculosis; Humans; Infectious Disease Medicine; Linezolid; Nitroimidazoles; Oxazoles; Practice Guidelines as Topic; Tuberculosis, Multidrug-Resistant; World Health Organization | 2015 |
Evaluation of tedizolid against Staphylococcus aureus and enterococci with reduced susceptibility to vancomycin, daptomycin or linezolid.
Topics: Anti-Bacterial Agents; Daptomycin; Drug Resistance, Bacterial; Enterococcus; Enterococcus faecalis; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Staphylococcus aureus; Vancomycin | 2016 |
Contribution of Oxazolidinones to the Efficacy of Novel Regimens Containing Bedaquiline and Pretomanid in a Mouse Model of Tuberculosis.
Topics: Animals; Antitubercular Agents; Bacterial Load; Diarylquinolines; Disease Models, Animal; Drug Administration Schedule; Drug Combinations; Drug Resistance, Multiple, Bacterial; Drug Synergism; Female; Linezolid; Lung; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Nitroimidazoles; Organophosphates; Oxazoles; Oxazolidinones; Pyrazinamide; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary | 2016 |
Chiral separation of tedizolid using charge single isomer derivatives of cyclodextrins by capillary electrokinetic chromatography.
Topics: Cyclodextrins; Electrophoresis, Capillary; Linezolid; Organophosphates; Oxazoles; Stereoisomerism | 2016 |
In vitro activity of tedizolid against linezolid-resistant staphylococci and enterococci.
Topics: Anti-Bacterial Agents; Drug Resistance, Bacterial; Enterococcus; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Organophosphates; Oxazoles; RNA, Ribosomal, 23S; Staphylococcus | 2016 |
Comparative Efficacies of Tedizolid Phosphate, Linezolid, and Vancomycin in a Murine Model of Subcutaneous Catheter-Related Biofilm Infection Due to Methicillin-Susceptible and -Resistant Staphylococcus aureus.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Catheter-Related Infections; Linezolid; Methicillin; Methicillin-Resistant Staphylococcus aureus; Mice; Organophosphates; Oxazoles; Staphylococcus aureus; Vancomycin | 2016 |
Activities of Tedizolid and Linezolid Determined by the Reference Broth Microdilution Method against 3,032 Gram-Positive Bacterial Isolates Collected in Asia-Pacific, Eastern Europe, and Latin American Countries in 2014.
Topics: Anti-Bacterial Agents; Asia; Enterococcus faecalis; Europe, Eastern; Gram-Positive Bacterial Infections; Humans; Latin America; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Staphylococcus aureus; Streptococcus agalactiae; Streptococcus pyogenes | 2016 |
Tedizolid susceptibility in linezolid- and vancomycin-resistant Enterococcus faecium isolates.
Topics: Anti-Bacterial Agents; DNA, Bacterial; DNA, Ribosomal; Drug Resistance, Bacterial; Enterococcus faecium; Gram-Positive Bacterial Infections; Humans; Linezolid; Microbial Sensitivity Tests; Mutation; Organophosphates; Oxazoles; RNA, Ribosomal, 23S; Vancomycin-Resistant Enterococci | 2016 |
Early Clinical Response as a Predictor of Late Treatment Success in Patients With Acute Bacterial Skin and Skin Structure Infections: Retrospective Analysis of 2 Randomized Controlled Trials.
Topics: Anti-Bacterial Agents; Clinical Trials, Phase III as Topic; Humans; Linezolid; Models, Statistical; Organophosphates; Oxazoles; Randomized Controlled Trials as Topic; Retrospective Studies; Sensitivity and Specificity; Skin Diseases, Bacterial; Time Factors; Treatment Outcome | 2017 |
Cost-effectiveness of adding novel or group 5 interventions to a background regimen for the treatment of multidrug-resistant tuberculosis in Germany.
Topics: Adult; Antitubercular Agents; Clinical Protocols; Clinical Trials as Topic; Cost-Benefit Analysis; Diarylquinolines; Drug Costs; Drug Therapy, Combination; Female; Germany; Humans; Linezolid; Male; Nitroimidazoles; Observational Studies as Topic; Oxazoles; Quality-Adjusted Life Years; Treatment Outcome; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary | 2017 |
Correction of myelotoxicity after switch of linezolid to tedizolid for prolonged treatments.
Topics: Anti-Bacterial Agents; Linezolid; Oxazoles | 2017 |
Topics: Antitubercular Agents; Beijing; China; Clofazimine; Diarylquinolines; DNA Gyrase; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Fluoroquinolones; Gatifloxacin; Humans; Linezolid; Microbial Sensitivity Tests; Moxifloxacin; Mutation; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles | 2017 |
Prevention of High-Level Daptomycin-Resistance Emergence In Vitro in Streptococcus mitis-oralis by Using Combination Antimicrobial Strategies.
Topics: Anti-Bacterial Agents; Ceftaroline; Cephalosporins; Daptomycin; Drug Combinations; Drug Resistance, Bacterial; Gentamicins; Humans; Imipenem; Linezolid; Microbial Sensitivity Tests; Organophosphates; Oxazoles; Rifampin; Streptococcus mitis; Streptococcus oralis; Trimethoprim, Sulfamethoxazole Drug Combination | 2018 |
Validating a 14-Drug Microtiter Plate Containing Bedaquiline and Delamanid for Large-Scale Research Susceptibility Testing of Mycobacterium tuberculosis.
Topics: Antitubercular Agents; Clofazimine; Diarylquinolines; Drug Resistance, Multiple, Bacterial; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Reproducibility of Results; Tuberculosis; Tuberculosis, Multidrug-Resistant | 2018 |
Delamanid, Bedaquiline, and Linezolid Minimum Inhibitory Concentration Distributions and Resistance-related Gene Mutations in Multidrug-resistant and Extensively Drug-resistant Tuberculosis in Korea.
Topics: Antitubercular Agents; Diarylquinolines; DNA Mutational Analysis; DNA, Bacterial; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Humans; Linezolid; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Republic of Korea; Tuberculosis, Multidrug-Resistant | 2018 |
Use of Translational Pharmacokinetic/Pharmacodynamic Infection Models To Understand the Impact of Neutropenia on the Efficacy of Tedizolid Phosphate.
Topics: Animals; Anti-Bacterial Agents; Disease Models, Animal; Linezolid; Methicillin-Resistant Staphylococcus aureus; Mice; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Staphylococcal Skin Infections | 2019 |
Superior Efficacy of a Bedaquiline, Delamanid, and Linezolid Combination Regimen in a Mouse Tuberculosis Model.
Topics: Animals; Antitubercular Agents; Diarylquinolines; Disease Models, Animal; Drug Therapy, Combination; Linezolid; Mice; Mycobacterium tuberculosis; Nitroimidazoles; Oxazoles; Pyrazinamide; Recurrence; Tuberculosis | 2021 |
Outcomes of Children Born to Pregnant Women With Drug-resistant Tuberculosis Treated With Novel Drugs in Khayelitsha, South Africa: A Report of Five Patients.
Topics: Adult; Antitubercular Agents; Child Health; Child, Preschool; Diarylquinolines; Female; Humans; Infant; Infant Health; Linezolid; Nitroimidazoles; Oxazoles; Pregnancy; Pregnancy Outcome; Pregnant Women; South Africa; Tuberculosis, Multidrug-Resistant; Young Adult | 2021 |
Efficacy and safety of tedizolid in a patient with linezolid-induced neutropenia: A case report.
Topics: Anti-Bacterial Agents; Humans; Linezolid; Microbial Sensitivity Tests; Neutropenia; Organophosphates; Oxazoles; Oxazolidinones; Skin Diseases, Bacterial; Tetrazoles | 2021 |
Safety of Treatment Regimens Containing Bedaquiline and Delamanid in the endTB Cohort.
Topics: Antitubercular Agents; Diarylquinolines; Electrolytes; Humans; Linezolid; Nitroimidazoles; Oxazoles; Prospective Studies; Treatment Outcome; Tuberculosis, Multidrug-Resistant | 2022 |
Safety and Effectiveness Outcomes From a 14-Country Cohort of Patients With Multi-Drug Resistant Tuberculosis Treated Concomitantly With Bedaquiline, Delamanid, and Other Second-Line Drugs.
Topics: Antitubercular Agents; Clofazimine; Cohort Studies; Diarylquinolines; Electrolytes; Fluoroquinolones; Humans; Linezolid; Nitroimidazoles; Oxazoles; Prospective Studies; Rifampin; Tuberculosis, Multidrug-Resistant | 2022 |