Page last updated: 2024-08-21

oxazoles and isoxazoles

oxazoles has been researched along with isoxazoles in 521 studies

Research

Studies (521)

TimeframeStudies, this research(%)All Research%
pre-1990450 (86.37)18.7374
1990's25 (4.80)18.2507
2000's19 (3.65)29.6817
2010's25 (4.80)24.3611
2020's2 (0.38)2.80

Authors

AuthorsStudies
Fotsch, C; St Jean, DJ1
Gale, KN; Guidotti, A1
Diamantis, W; Ludwig, BJ; Sofia, RD2
Waddington, JL1
Sato, M; Stammer, CH1
Kuo, YH; Lambein, F; van Parijs, R1
Bashford, CL; Chance, B; Prince, RC1
Ballard, F; Kucharczyk, N; Myers, G; Sofia, RD; Yang, J1
Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Utsui, Y; Yoshida, K2
Arison, BH; Eskola, P; Kulsa, P; Miller, AK; Miller, BM; Miller, TW; Mrozik, H; Skeggs, H; Vandenheuvel, WJ; Zimmerman, SB1
Charlton, M; Goldblatt, D; Joynt, RJ; Shoulson, I1
Curtis, DR; Johnston, GA; Krogsgaard-Larsen, P; Lodge, D1
Biggio, G; Brodie, BB; Costa, E; Guidotti, A1
Beaumont, K; Chilton, WS; Enna, SJ; Yamamura, HI1
Snodgrass, SR1
Arnt, J; Krogsgaard-Larsen, P1
Chance, B; Smith, JC1
Bashford, CL; Chance, B; Smith, JC; Yoshida, T1
Douglas, JF; Edelson, J; Ludwig, BJ1
Banerjee, BN; Ivins, NJ; Ludwig, BJ; Sofia, RD1
Mizojiri, K; Nakajima, Y; Okabe, H; Sugeno, K; Watanabe, J; Yamamoto, R1
Grover, V; Joshi, KC; Pathak, VN1
Grover, V; Pathak, VN1
Kanazawa, M; Kawasaki, K; Ogiwara, T; Sato, K; Tsuyuzaki, K1
Diamantis, W; Edelson, J; Gordon, R; Ludwig, BJ; Sofia, RD1
Csapo, AI; Csapo, EF; Resch, B; Salau, G1
Berger, AE; Bloch, A; Grindey, GB; McPartland, RP; Neil, GL1
Bogden, AE; Houchens, DP; Johnson, RK; Neil, GL; Ovejera, AA; Sheridan, MA1
Akerman, KE; Wolff, CH1
Csapo, AI; Resch, BA1
Holcenberg, JS1
Karobath, M; Lippitsch, M1
Andrews, PR; Johnston, GA1
Kolasa, K1
Saunders, JC; Williamson, WR1
Gupta, RC; Kishor, K; Pandey, BR; Srivastava, VK1
Curtis, DR; Johnston, GA; Lodge, D1
Boissier, JR; Dumont, C; Oberlander, C1
Cools, AR; Scheel-Krũger, J; van Wel, PM1
Koella, WP; Olpe, HR1
Arnt, J; Christensen, AV; Scheel-Krüger, J2
Lakoski, JM; Walters, JR1
Hori, N; Ikeda, K; Roberts, E1
Leach, MJ; Wilson, JA1
Hashimoto, M; Utsui, Y; Yamaguchi, T1
DiPasquale, G; Gingold, J; Rassaert, C; Schwartz, E; Welaj, P1
Yarbrough, GG1
Johnston, GA; Krogsgaard-Larsen, P2
Berger, AE; Bhuyan, BK; Blowers, CL; Kuentzel, SL; Neil, GL1
Ravagnan, G; Salfi, V; Strom, R1
Berlin, KD; Chesnut, RW; Durham, NN; Hashem, MM1
Berlin, KD; Chesnut, RW; Durham, NN; Mawdsley, EA1
Nicoletti, M; Ravagnan, G; Renzini, G; Strom, R1
Bella, DD; Biggio, G; Frigeni, V; Guidotti, A1
Cools, AR; Honig, W; Scheel-Krüger, J1
El-Rabbat, NA; Omar, NM1
Carr, JB; Durham, HG; Hass, DK1
Hines, JW; Stammer, CH1
Biggio, G; Casu, M; Corda, MG; Gessa, GL; Vernaleone, F1
Stamm, H; Steudle, H3
Gorecki, DK; Peesker, SJ; Wood, JD1
Beam, CF; Dasher, LW; Harris, CE; Shealy, KD; Shealy, NL1
Hashimoto, S; Shizu, M; Takahashi, S1
Chance, B; Cooperman, BS; Russ, P; Smith, JC1
Cheney, DL; Costa, E; Zsilla, G1
DiPasquale, G; Rassaert, C; Tripp, L; Welaj, P1
Bausi, L; Bramanti, G; Maoggi, M; Renzi, G1
Furukawa, K; Karasawa, T; Shimizu, M; Yoshida, K1
Ito, T; Shimizu, M; Yoshida, K1
Douglas, JF; Edelson, J; Ludwig, BJ; Schuster, EB; Shahinian, S1
Ansbacher, R1
Schunack, W1
Baczysnkyj, L; Chidester, CG; Duchamp, DJ; Martin, DG; Mizsak, SA1
Albrecht, HP; Moffatt, JG; Repke, DB1
Belter, PA; Coleman, TA; Gerpheid, SA; Hanka, LJ; Martin, DG; Meyer, HF; Spieles, PR1
Goldman, AS; Shapiro, BH1
Denzel, T; Janssen, W1
Arena, F; Manna, F; Parente, L; Stein, ML1
Abignente, E; De Caprariis, P; Stein, ML1
DiPasquale, G; Gingold, J; Rassaert, C; Richter, R; Singer, R; Welaj, P1
Minami, N; Suzuki, Y1
Furukawa, H; Hayashi, Y; Imai, K; Matsuura, M1
Bodin, JI; Brenner, IA; Reisberg, P1
Freedman, JC; Novak, TS; Pratap, PR1
Lau, SS; Monks, TJ1
Ishii, H; Kalbe, K; Kurooka, S; Naruto, S; Nishimura, S; Sunahara, N1
Cao, LQ; Chance, WT; Fischer, JE1
Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y1
Charles, CL; Stoesz, L; Tollefson, G1
Edwards, WD; Lefler, BJ; Natale, NR; Palmer, RB; Triggle, DJ1
Jodogne, C; Tirelli, E1
Bailey, TR; Diana, GD; Dutko, FJ; Oglesby, RC; Pevear, DC; Treasurywala, AM1
Boeyé, A; Brioen, P; Rombaut, B1
Bruce, D; Cooper, CE; Nicholls, P1
Belhage, B; Hansen, GH; Meier, E; Schousboe, A4
de Tarlovsky, MN; Goijman, SG; Molina Portela, MP; Stoppani, AO1
Allen, SD; Bennett, GA; Georgiev, VS; Mitchell, JT; Mullen, GB; Swift, PA1
Dan, T; Koga, H; Tanaka, H1
Allen, SD; Kinsolving, CR; Maryniak, DM; Mitchell, JT; Mullen, GB; St Georgiev, V3
Christopherson, RI; Lyons, SD; Sant, ME1
Hasegawa, H; Okuda, H; Wada, Y; Yamaguchi, N1
Bhaduri, A; Mukherjee, T; Roy, K1
Bailey, H; Earhart, RH; McGovren, JP; Williams, MG1
Ardalan, B; Chandrasekaran, B; Hrishikeshavan, HJ1
Hanson, RL; Isaacson, CM1
Chused, TM; Wilson, HA1
Prajda, N1
Naumov, AP; Neguliaev, IuA; Vedernikova, EA1
Schauf, CL1
Apell, HJ; Bersch, B1
Awouters, F; Janssen, PA; Meert, TF; Megens, AA; Niemegeers, CJ; Schellekens, KH1
de Chaffoy de Courcelles, D; Eens, A; Gommeren, W; Janssen, PA; Leysen, JE; Stoof, JC1
Awouters, FH; Megens, AA; Niemegeers, CJ1
de Haes, P; Janssen, PA; Meert, TF1
Burton, P; Gelders, Y; Heylen, S; Mesotten, F; Pietquin, M; Suy, E1
de Bruyckere, K; Janssen, PF; Leysen, JE; Schotte, A1
Dugovic, C; Janssen, PA; Wauquier, A1
Duncan, JS; Hart, YM; Sander, JW; Shorvon, SD1
Gonsalves, SF; Harbaugh, RE; Krogsgaard-Larsen, P; Schousboe, A; Twitchell, B1
Guidinger, PL; Jubelt, B; McKinlay, MA; Ropka, SL; Wilson, AK1
Badger, J; Dutko, FJ; Fancher, M; Heinz, BA; McKinlay, MA; Rossmann, MG; Rueckert, RR; Shepard, DA; Smith, TJ1
Bruns, RF; Drummond, J; Johnson, G; Nickell, DG; Ortwine, DF; Welbaum, B1
Agmo, A; Paredes, R; Soria, P1
Diana, GD; Dutko, FJ; McKinlay, MA; Otto, MJ; Rogge, MC; Woods, MG1
Della Bella, D1
Löfdahl, CG; Sigvaldasson, A; Skoogh, BE; Svedmyr, N1
Bianco, S1
Ziment, I1
Allegra, L1
Ikegami, T; Natsumeda, Y; Weber, G1
Ardalan, B; Deas, M; Jayaram, HN; Johnson, RK1
Mellor, JM; Mills, GA; Walker, V1
Allen, SD; Bennett, GA; DeCory, TR; Jones, WE; Maryniak, DM; Mitchell, JT; Mullen, GB; St Georgiev, V1
Allen, SD; Bennett, GA; Mitchell, JT; Mullen, GB; St Georgiev, V2
Berger, R; Schierbeek, H1
Bartlett, RR; Langer, KH; Schleyerbach, R; Sitter, T; Thoenes, GH1
Andersen, JV; Dalgaard, L; Hansen, SH1
Dwivedi, B; Tiwari, N1
Allen, SD; Georgiev, VS; Mitchell, JT; Mullen, GB1
Allen, SD; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA1
Einspahr, FJ; McGovren, JP; Piercey, MF; Schreur, PJ; Tang, AH; VonVoigtlander, PF; Williams, MG1
Futami, H; Irino, S; Shiotani, T; Yamaji, Y; Yamauchi, N1
Briñon, MC; de Bertorello, MM; Longhi, MR1
Genchi, G; Palmieri, F; Wolf, G1
Allen, SD; Kinsolving, CR; Mitchell, JT; Mullen, GB; Ordy, MJ; Palmer, GC; Radov, LA; Simmons, RD; St Georgiev, V; Strand, JC1
Kandul, SV; Sinitskaia, TA1
Callens, M; De Bruyne, CK; Kersters-Hilderson, H; Vangrysperre, W1
Carenzi, A; Chiarino, D; Napoletano, M; Reggiani, A; Sala, A; Sala, R1
Liske, S; Morris, ME1
Chitneni, SR; Moore, JO; Nichols, KE; Weinberg, JB1
Davis, TE; Earhart, RH; Faraggi, D; Khandekar, JD; Schinella, RA1
Habermehl, KO; McKinlay, MA; Otto, MJ; Willingmann, P; Zeichhardt, H1
Fujimoto, M; Guidotti, A; Hanbauer, I; Kataoka, Y1
Diana, GD; Maliski, EG; McKinlay, MA; Oglesby, RC; Otto, MJ; Rossmann, MG; Smith, TJ; Treasurywala, AM1
Cosi, C; Wood, PL1
Spealman, RD; Wettstein, JG1
Itoh, N; Mimaki, T; Suzuki, Y; Tagawa, T; Tanaka, J; Yabuuchi, H1
Byberg, JR; Curtis, DR; Falch, E; Gynther, BD; Hjeds, H; Krogsgaard-Larsen, P; Labouta, IM1
Capraro, MA; Hughey, RP1
Burk, RF; Hill, KE; Von Hoff, DD1
Allen, RC; Dunn, RW; Ellis, DB; Gardner, BA; Glamkowski, EJ; Huger, FP; Jones, MC; Schmid, BL; Stache, U; Strupczewski, JT1
Corsico, R; Lodola, E; Majani, U; Rampulla, C1
Hansen, SH; Krogsgaard-Larsen, P; Nielsen, EO; Schousboe, A1
Catt, JD; Eison, MS; Lobeck, WG; Minielli, JL; New, JS; Riblet, LA; Smith, DW; Taylor, DP; Temple, DL; Yevich, JP1
Bruno, G; Chase, TN; Cox, C; Fedio, P; Foster, N; Gillespie, M; Hare, TA; Mohr, E; Tamminga, C1
Carenzi, A; Chiarino, D; Della Bella, D; Fantucci, M; Frigeni, V; Sala, R1
Sastrasinh, M; Sastrasinh, S2
Bianco, S; Robuschi, M; Simone, P; Vaghi, A; Ventresca, GP1
Curthoys, NP; Scott, RD1
Bründler, H; Godly, R; Herzog, H; Imhof, E; Perruchoud, AP1
Harris, C; Juchau, MR; Stark, KL1
Cafaggi, R; D'Onofrio, V; Giosuè, S; Guerrini, P; Perrone, N; Scano, M1
Casali, L; Colombo, ML; Manazza, P; Rossi, A; Zoia, MC1
Davis, ME1
Chetta, A; Cuomo, A; Garavaldi, G; Gurrieri, G; Olivieri, D1
Aoki, T; Oya, H2
Akullian, V; Cutcliffe, D; Diana, GD; Mallamo, JP; McKinlay, MA; Oglesby, RC; Otto, MJ1
Bagri, A; Di Scala, G; Sandner, G1
Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N1
Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A1
Costa, LG; Enna, SJ; Pelley, K; Setler, P; Vaught, JL1
Brisson, CJ; Diana, GD; McKinlay, MA; Miralles, JV; Salvador, UJ; Zalay, ES1
Gähwiler, BH; Graff, P; Maurer, R; Nordmann, R1
Diana, GD; Fancher, MJ; Fox, MP; Kuhrt, MF; McKinlay, MA; Otto, MJ1
Akullian, V; Diana, GD; McKinlay, MA; Oglesby, C; Otto, MJ1
Depaulis, A; Vergnes, M2
Hösli, E; Hösli, L; Krogsgaard-Larsen, P1
Brehm, L; Curtis, DR; Falch, E; Johansen, JS; Krogsgaard-Larsen, P; Schaumburg, K1
Chweh, AY; Swinyard, EA; Ulloque, RA1
Ryan, TM; Zoutendam, PH1
Belhage, B; Meier, E; Schousboe, A1
Braestrup, C; Krogsgaard-Larsen, P; Nielsen, M1
Fox, MP; McKinlay, MA; Otto, MJ1
Eisenhauer, E; Maksymiuk, A; Maroun, JA; Pater, J; Stewart, DJ; Young, V1
Akullian, V; Carabateas, PM; Cutcliffe, D; Diana, GD; Maliski, EG; Mallamo, JP; McKinlay, MA; Michalec, SJ; Oglesby, RC; Otto, MJ1
Shavrin, AS; Zharkovskaia, TA; Zharkovskiĭ, AM1
Apud, JA; Masotto, C; Racagni, G1
Chweh, AY; Swinyard, EA; Wolf, HH1
Enna, SJ; Zorn, SH2
Gillis, RA; Hamosh, P; Hartley, B; Quest, JA; Taveira da Silva, AM1
Allen, SD; Dormer, PA; Mitchell, JT; Mullen, GB; St Georgiev, V1
Löscher, W1
Cao, L; Chance, WT; Fischer, JE; Foley-Nelson, T; Nelson, JL1
Gumnit, RJ; Henry, TR; Jacobs, M; Leppik, IE1
Hirschelmann, R; Schade, R1
Cao, L; Chance, WT; Fischer, JE1
Ogawa, K; Yamawaki, I1
Kawasaki, T; Shimizu, A; Tanaka, M; Yamada, Y; Yamamoto, J1
Hagendoorn, MJ; Kraayenhof, R; Krab, K; van Walraven, HS1
Brunner, EA; Cheng, SC1
Capizzi, RL; Craig, JB; Powell, BL; Richards, F1
Carbone, PP; Davis, TE; Earle, JD; Elson, PJ; Glover, DJ; Hahn, RG; Kvols, LK; Trump, DL; Vogl, SE1
Allen, SD; DeCory, TR; Georgiev, VS; Kinsolving, CR; Mitchell, JT; Mullen, GB1
Basson, M; Ernst, LA; Freedman, JC; George, EB; Nyirjesy, P; Pratap, PR; Waggoner, AS1
Kochetov, GA; Kuimov, AN1
Bennett, GA; DeCory, TR; Dormer, PG; Maryniak, DM; Mullen, GB; St Georgiev, V; Swift, PA1
Allen, SD; Kinsolving, CR; Maryniak, DM; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA1
Allen, SD; DeCory, TR; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V1
Allen, SD; DeCory, TR; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA1
Allen, SD; Bennett, GA; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA3
Allen, SD; Bennett, GA; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V1
Allen, SD; Mitchell, JT; Mullen, GB; St Georgiev, V2
Allen, SD; Bennett, GA; DeCory, TR; Mitchell, JT; Mullen, GB; St Georgiev, V1
Ishibashi, M; Miyazaki, H; Mizugaki, M; Nakagawa, Y; Sagi, M; Takayama, H; Yamanaka, H1
Krogsgaard-Larsen, P; Schousboe, A; Wood, JD1
Baumann, K; Binder, D; Holzer, W; Noe, CR2
Barsoum, NJ; DiFonzo, CJ; Macallum, GE; Smith, GS; Walker, RM1
Basson, M; Freedman, JC; George, EB; Gupta, RK; Nyirjesy, P; Pratap, PR; Raman, K; Waggoner, AS1
Freedman, JC; George, EB; Nyirjesy, P; Pratap, PR; Waggoner, AS1
Luther, RR; Patterson, KJ; Ringham, GL; Thomas, EW; Tolman, KG1
Lisgarten, JN; Palmer, RA1
Allen, SD; Kinsolving, CR; Mullen, GB; Ordy, JM; Palmer, GC; Simmons, RD; St Georgiev, V; Strand, JC1
Cao, L; Chance, WT; Fischer, JE; Kim, MW; Nelson, JL1
Flaim, SF; Maryanoff, BE; McKenna, JI; Natale, NR; Schlicksupp, L; Willett, RD1
Emrani, J; Hashimoto, Y; Ikegami, T; Natsumeda, Y; Prajda, N; Reardon, MA; Szondy, S; Weber, G1
Borsini, F; Giuliani, S; Meli, A1
Huber, KR; Roberts, J; Rosenfeld, H1
Friberg, L; Roland, PE1
Cortez, C; DiGiovanni, J; Harvey, RG; Sawyer, TW1
Dannhardt, G; Grobe, A; Gussmann, S; Obergrusberger, R; Ziereis, K1
Drower, EJ; Hammond, DL2
Dain, JG; Jaffe, JM; Orwig, BA; Tse, FL1
Sweet, F; Varga, B1
Furukawa, K; Hori, M; Ito, T; Kadokawa, T; Karasawa, T; Matsuno, Y; Noda, Y; Ochi, Y; Oka, M1
Fujitani, B; Ito, T; Kadokawa, T; Matsuno, Y; Nakamura, N; Nakatsuji, K1
Depaulis, A; Liebeskind, JC; Morgan, MM1
Fukuda, H; Ito, S; Kurashige, S; Miyazaki, H; Mizugaki, M; Narita, K; Sakamoto, T; Tatee, T; Yamanaka, H2
Eisenhauer, EA; Fields, AL; Maroun, JA; Walde, PL1
Adhikari, VA; Badiger, VV1
Georgiev, VS; Mullen, GB; Swift, PA1
Avioli, LV; Civitelli, R; Halstead, LR; Hruska, KA; Reid, IR1
Bartlett, RR1
Buyniski, JP; Gylys, JA; Pasternak, RD; Siminoff, P; Wadopian, NS; Wright, RN1
Maniwa, M; Marunaka, T1
Birch, R; Greco, A; Johnson, R; Kramer, BS; Prestridge, K1
Chang, YC; Falkson, G; Knuiman, MW; Pandya, KJ; Skeel, RT; Willson, JK; Wolter, JM1
Booth, BW; Budman, D; Ellison, RR; Khojasteh, A; Korzun, AH; Weiss, RB; Wood, W1
Brewer, JM; Sinha, U1
Hammond, EJ; McLean, JR; Perchalski, RJ; Wilder, BJ1
Juergens, U1
Massacesi, M; Pinna, R; Ponticelli, G; Puggioni, G1
Borden, EC; Falkson, G; Simson, IW; Vorobiof, DA1
Bañez, M; Ciciani, G; Dal Piaz, V; Torroba, T; Vadillo, S; Valle, J1
Balsamini, C; Duranti, E; Scheda, P1
Huber, KR; Mayer, EP; Mitchell, DF; Roberts, J1
Kanai, S; Kitani, K; Masuda, Y; Nokubo, M; Ohta, M; Sato, Y1
Zarkovsky, AM1
Liebeskind, JC; Morgan, MM; Stein, C1
Jaffe, JM; Orwig, B; Tse, FL1
Kadokawa, T; Kawashima, K; Mizuta, H; Naruto, S; Ueda, S; Yoshida, T1
Jørgensen, OS; Meier, E; Schousboe, A1
Albini, E; Carenzi, A; Chiarino, D; Della Bella, D; Napoletano, M; Sala, A1
Borsini, F; Evangelista, S; Meli, A1
Blessing, JA; Buchsbaum, HJ; DiSaia, PJ; McGuire, WP1
Meder, J; Rehse, K1
Martin, DG; Mizsak, SA; Nielsen, JW1
Ito, S; Kurashige, S; Miyazaki, H; Mizugaki, M; Narita, K; Sakamoto, T; Shiozawa, A; Takei, M; Tatee, T; Yamanaka, H1
Adolphson, CC; Ajani, JA; Barlogie, B; Bedikian, AY; Bodey, GP; Korinek, J; Stroehlein, JR1
McKinlay, MA; Steinberg, BA1
Engler, J; Hjeds, H; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD1
Hirate, K; Shinozaki, H1
Benziger, DP; Frank, JA; McKinlay, MA; Steinberg, BA1
Buchanan, RA; Friel, PN; Levy, RH; McLean, JR; Ojemann, LM; Shastri, RA; Wilensky, AJ1
Christopherson, RI; Kemp, AJ; Lyons, SD1
Bammel, BP; Brand, JA; Evans, D; Simmons, RB; Smith, JC1
Pedersen, EB; Tanaka, K1
Bartlett, RR; Popovic, S1
Achleitner, E; Lui, MS; Weber, G1
Gerok, W; Häussinger, D; Holstege, A; Pausch, J; Rasenack, J1
Bartlett, RR; Schleyerbach, R1
Dua, RD; Kochhar, S1
Blandino, G; Pappalardo, MS; Ronsisvalle, G; Vittorio, F1
Ardalan, B; Belt, RJ; Benjamin, RS; McGovren, JP; Ohnuma, T; Pratt, EA; Taylor, SA1
Earhart, RH; Neil, GL1
Boyajy, LD; Hanson, RL; Isaacson, CM1
Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM1
Boyer, TD1
Dingledine, R; Korn, SJ1
Aoki, T; Eble, JN; Glover, JL; Sebolt, JS; Weber, G1
Alder, GM; Bashford, CL; Gray, MA; Micklem, KJ; Pasternak, CA; Taylor, CC; Turek, PJ1
Kostyniak, PJ; Mulder, KM1
Mezentsev, AS; Ostashevich, NE; Panina, MA; Vtorov, IB1
Cornford, EM; Landon, KP1
McGovren, JP; Roach, BL; Robins, RH; Williams, MG1
Bajardi, ML; Daidone, G; Plescia, S; Raffa, D1
McKinlay, MA1
Anfinsen, CB; Dunn, BM1
Lambein, F; Van Parijs, R1
Janda, J1
Karasawa, T; Masuda, M; Oka, M; Shimizu, M; Yoshida, K1
Cynader, M; Needler, MC; Shaw, C1
Minchin, MC; Nutt, DJ1
Mozhaeva, GN; Naumov, AP; Nosyreva, ED1
Jensen, MS; Lambert, JD1
Allen, L; Meck, R; Yunis, A1
Ellis, WW; Meck, RA; Reed, DJ1
Allen, LM; Thornthwaite, JT1
Allen, LM; Corrigan, MV; Meinking, T1
Arnt, J; Christensen, AV1
Gardell, SJ; Tate, SS1
Kozak, EM; Tate, SS1
Curthoys, NP; Shapiro, RA1
Dass, PD; Welbourne, TC1
Casey, DE; Gerlach, J; Hetmar, O; Kaldan, B; Korsgaard, S; Mikkelsen, LB1
Forchetti, MC; Guidotti, A; Krogsgaard-Larsen, P; Moroni, F1
Karobath, M; Supavilai, P1
Curthoys, NP; Reed, DJ; Schasteen, CS1
Fujii, T; Hashimoto, M; Kagemoto, A; Maeda, T; Matsumoto, K; Miyazaki, H1
Persson, B1
Aoki, T; Burt, ME; Denton, JE; Faderan, MA; Lui, MS; Prajda, N; Reardon, MA; Sebolt, J; Weber, G; Zhen, YS1
Bhalla, K; Deitch, A; Grant, S; Nayak, R1
Elliott, WL; Faderan, MA; Liepnieks, JJ; Lui, MS; Natsumeda, Y; Weber, G1
Gromet-Elhanan, Z; Khananshvili, D1
Carl, PL; Chakravarty, PK; Katzenellenbogen, JA; Weber, MJ1
Chase, TN; Denaro, A; Foster, NL; Hare, TA; Tamminga, CA1
Cross, AJ; Waddington, JL1
Hanstein, WG; Kiehl, R1
Kelly, PA; McCulloch, J2
Aaes-Jørgensen, T; Bøgesø, KP; Krogsgaard-Larsen, P; Mikkelsen, H; Schultz, B1
Brehm, L; Krogsgaard-Larsen, P; Schaumburg, K1
Falch, E; Krogsgaard-Larsen, P1
Blavet, N; Clostre, F; DeFeudis, FV1
Blavet, N; Clostre, F; De Feudis, FV1
Dias Souza, J; Gillis, RA; Quest, JA; Williford, DJ1
Curtis, DR; Hjeds, H; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ1
Christensen, AV; Krogsgaard-Larsen, P; Svendsen, O1
Blavet, N; DeFeudis, FV1
Mondrup, K; Pedersen, E1
Curtis, DR; Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Leah, JD; Mikkelsen, H; Peet, MJ1
Johnston, GA; Skerritt, JH1
Costa, LG; Murphy, SD1
Dafny, N; Reyes-Vázquez, C1
Bank-Mikkelsen, OK; Valentin, N1
Hoehn-Saric, R1
Altmann, H; Dose, M; Emrich, HM; von Zerssen, D1
Iwagami, H; Sasaki, Y; Yasuda, N1
Bjørndal, N; Christensson, E; Gerlach, J1
Bunnell, PR; Crowley, SR; Dodge, PW; Fung, AK; Pariza, RJ; Parks, JA; Pernet, AG; Plattner, JJ1
Alonso, MT; Leyland-Jones, B; O'Dwyer, PJ1
Evans, BR; Wierenga, W; Zurenko, GE1
Kabakov, AN; Kochetov, GA; Kuimov, AN; Meshalkina, LE; Tsorina, ON1
Cripps, C; Eisenhauer, E; Fields, AL; Maroun, JA; Pater, JL; Stewart, DJ1
Machoń, Z; Ryng, S2
Berent, S; Donofrio, PD; Sackellares, JC; Sakmar, E; Wagner, JG1
Belt, RJ; Haas, CD; Hoogstraten, B; Joseph, U; Taylor, S1
Imai, H; Iwanami, M; Miyazaki, S; Suzuki, K; Tanaka, K; Watanabe, S1
Sone, H; Takayanagi, I1
Di Scala, G; Karli, P; Schmitt, P1
DeFeudis, FV1
Kjaer, M; Nielsen, H1
Følsgård, S; Jacobsen, E; Lindeburg, T; Madsen, SM; Sillesen, H1
DeFeudis, FV; Grognet, A; Hertz, F3
Danĕk, J; Spaldonová, R; Sváb, A; Zikán, V1
Agnoli, A; Chase, TN; Denaro, A; Ruggieri, S; Tamminga, CA1
Macdonald, RL; Skerritt, JH1
Bittner, G; Fischer, PH; Pamukcu, R; Willson, JK1
Horton, R; Meldrum, B1
Maragoudakis, ME; Richon, AB; Wasvary, JS1
Ardalan, B; Jayaram, HN; Johnson, RK1
Lui, MS; Weber, G; Zhen, YS1
Følsgård, S; Jacobsen, E; Kehlet, H; Lindeburg, T; Sillesen, H1
Andree, T; Enna, SJ; Kendall, DA1
Johnson, DD; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD1
Dam, M; Jensen, I; Petersen, HR1
Gomi, S; Hamada, M; Iinuma, K; Iitaka, Y; Ikeda, D; Ikeda, T; Ikeda, Y; Kondo, S; Nakamura, H; Takeuchi, T; Umezawa, H1
Cheney, DL; McGill, W; Murray, TF1
Madsen, SM1
Keppler, DO; Leube, K1
Bodey, G; Fleishman, G; Murphy, WK; Yap, HY1
Allen, RC; Försch, MF; Setescak, LL; Shutske, GM; Wilker, JC1
Ishida, S; Ito, T; Kakegawa, N; Miyazaki, H; Seino, M; Sekine, Y; Shimizu, M; Wada, T; Yagi, K; Yamaguchi, T1
Inaba, T; Wiest, WG1
Bień, I; Domagalina, E1
Lacey, R1
Bower, SG; Tso, JY; Zalkin, H1
Maugh, TH1
Armitage, JP; Evans, MC1
Bruno, S; McGovren, JP; Neil, GL; Penta, J; Poster, DS1
Lombardo, D2
Hansen, SH; Schultz, B1
Aoki, T; Denton, JE; Lui, MS; Sebolt, J; Weber, G1
Aoki, T; Sebolt, J; Weber, G1
Elfring, GL; McGovren, JP; Poplack, DG; Smith, RB; Soares, N; Stewart, JC; Von Hoff, DD; Wood, JH1
DiPasquale, G; Fabian, AC; Genzer, JD; Kasulanis, CF; Lindo, N; Lutomski, C; Schwartz, ML; Shavel, J; Sircar, JC; Zinnes, H1
Allen, RC; Davis, L; Effland, RC; Kitzen, JM; Novick, WJ; Ranbom, K; Setescak, LL; Shutske, GM; Wilker, JC1
Kufe, DW; McGovren, JP; Schade, D; Weiss, GR1
Cooney, DA; Jayaram, HN; Kensler, TW1
Kizaki, H; Lui, MS; Weber, G1
Berkenkoph, J; Fernandez, X; Friary, R; Green, MJ; Lutsky, BN; Monahan, M; Tiberi, RL1
Kadokawa, T; Kawashima, K; Sohji, Y; Sone, H; Takayanagi, I1
Christensen, AV; Larsen, JJ1
Hori, M; Ito, T; Masuda, Y; Shimizu, M; Yoshida, K1
Buescher, HH; Hill, RC; Maurer, R; Roemer, D1
Chan, PJ; McGovren, JP; Neil, GL; Stewart, JC1
Roberts, J; Rosenfeld, H1
Kamei, C; Masuda, Y; Oka, M; Shimizu, M; Yoshida, K1
Hirai, E; Imanishi, H; Umeda, T1
Li, YG; Ma, LT; Wang, X1
Kuhar, MJ; London, ED; Palacios, JM; Rapoport, SI1
Hallidy, L; Smith, JC; Topp, MR1
Kufe, DW; Loh, E1
Dinur, D; Hajdu, J; Kantrowitz, ER1
Biles, C; Martin, DG; Mizsak, SA1
Allen, LM; Clubb, KJ; Meck, RA; Yunis, AA1
Menon, MK1
Bergstrom, DA; Walters, JR; Waszczak, BL1
Aaes-Jørgensen, T; Bøgesø, KP; Jørgensen, A; Schultz, B1
Mizojiri, K; Nakajima, Y; Okabe, H; Sugeno, K; Watanabe, J; Yamamoto, E2
Hilton, JG1
Homandberg, GA; Minor, ST; Peanasky, RJ1
Hori, M; Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Yoshida, K1
Henry, JP; Scherman, D1
Hruska, RE; Walters, JR; Waszczak, BL1
Arison, BH; Kirkman-Bey, N; Onofrey, D; Pile, J; Vandenheuvel, WJ; Zweig, JS1
Cooney, DA; Kensler, TW; Reck, LJ1
Broom, NJ; Elder, JS; Hannan, PC; O'Hanlon, PJ; Pons, JE; Walker, G; Wilson, J; Woodall, P1
Iwao, M; Onogi, S; Shibata, T; Shinkai, H; Tanaka, M; Uchida, I; Wakitani, K1
Aron, ZD; Fink, BE; Katzenellenbogen, JA; Mortensen, DS; Stauffer, SR1
Cho, YS; Choi, JH; Choi, KI; Joo, HJ; Kim, BH; Kim, HY; Koh, HY; Pae, AN1
Diana, GD; Hadfield, AT; Rossmann, MG1
Forsythe, MS; Khurana, S; Mousa, SA1
Crump, CE; Hayden, FG; Kaiser, L1
Turner, RB1
Gersten, M; Hsyu, PH; Kerr, BM; Penning, CA; Pithavala, YK1
Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS1
Barrish, JC; Bird, E; Chen, P; Chong, S; Gu, Z; Hermsmeier, M; Humphreys, WG; Koplowitz, B; Leith, L; Liu, EC; Marino, A; Mathur, A; Moreland, S; Morrison, RA; Murugesan, N; Spergel, S; Trippodo, N; Waldron, T; Webb, ML; Young, M; Zhang, R1
Tschirret-Guth, RA; Wood, HB1
FEDI, M; GIANNINI, M1
TANAKA, N; UMEZAWA, H1
ACKERMAN, JH; ARNOLD, A; BEYLER, AL; CHRISTIANSEN, RG; CLARKE, RL; CLINTON, RO; DEAN, JW; MANSON, AJ; NEUMANN, HC; PAGE, DF; PHILLIPS, DK; POTTS, GO; STONNER, FW1
AIELLO, T; FABRA, J; SPRIO, V1
ADACHI, I; KANO, H; YAMAZAKI, E1
KOCHETKOV, NK; SOKOLOV, SD1
FUJIMOTO, M; SAKAI, M1
Chase, E; Harris, K; Katpally, U; Reisdorph, N; Siuzdak, G; Smith, TJ; Thomas, JJ1
Amano, H; Hayashi, I; Inukai, M; Kamata, M; Kitasato, H; Majima, M; Yoshida, S; Yoshimura, H1
Chi-Burris, K; Gersten, M; Gwaltney, JM; Hayden, FG; Hsyu, P; Patick, AK; Smith, GJ; Turner, RB; Zalman, LS1
Hitesh, NA; Mallesha, H; Rangappa, KS; Sadashiva, MP1
Ashton, WT; Dong, H; Doss, GA; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Sisco, RM; Thornberry, NA; Weber, AE; Wu, JK1
Alcázar, J; Alonso, JM; Alvarez, RM; Andrés, JI; Bakker, MH; Biesmans, I; Cid, JM; De Lucas, AI; Drinkenburg, W; Fernández, J; Font, LM; Iturrino, L; Langlois, X; Lenaerts, I; Martínez, S; Megens, AA; Pastor, J; Pullan, S; Steckler, T1
Tao, J; Zhao, L1
Moreira, R; Santos, MM1
Bewley, CA; Fetterolf, BJ; Gutierrez-Lugo, MT; Metaferia, BB; Moravec, M; Ray, S; Shazad-Ul-Hussan, S; Smith, JA1
Ahmed, AA; Albert, DH; Bouska, JJ; Bousquet, PF; Cunha, GA; Davidsen, SK; Diaz, G; Glaser, KB; Guo, J; Harris, CM; Ji, Z; Li, J; Marcotte, PA; Michaelides, MR; Moskey, MD; Oie, T; Pease, L; Soni, NB; Stewart, KD1
Makarov, VA; Riabova, OB; Schmidtke, M; Wutzler, P; Zieger, R1
Cottyn, B; Goumont, R; Shevelev, S; Starosotnikov, A; Terrier, F; Vichard, D1
Chiacchio, U; Corsaro, A; Merino, P; Romeo, G1
Böttcher, T; Orth, R; Sieber, SA1
Endo, T; Kanda, T; Nakamura, H; Sakuma, S; Yamakawa, T; Yamasaki, S1
Fausto, R; Gómez-Zavaglia, A; Lopes, S; Nunes, CM; Pinho e Melo, TM1
Deadman, J; Jones, ED; Le, G; Smith, JA1
Muralikrishna, A; Padmaja, A; Padmavathi, V; Rajasekhar, C1
Boshoff, H; Chang, M; Cho, S; Franzblau, SG; Hwang, CH; Markley, LD; Miller, MJ; Moraski, GC1
Gochfeld, DJ; Kamel, HN; Olson, JB; Thacker, RW1
Fausto, R; Nunes, CM; Reva, I1
Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M1
Bertolotto, A; Finardi, A; Furlan, R; Hintermann, S; Martire, S; Montarolo, F; Perga, S; Raffaele, C1
Bujak, A; Dymek, B; Dzwonek, K; Grygielewicz, P; Gunerka, P; Lamparska-Przybysz, M; Stanczak, A; Wieczorek, M; Zdzalik, D1
Chatterley, A; Elsegood, MR; Jones, RC; Marty, R; Owton, WM1
Furuta, K; Liu, G; Ozoe, F; Ozoe, Y1
Su, MD1
Imrich, J; Kožíšek, J; Ungvarská Maľučká, L; Vilková, M1
Ichikawa, S1
Nagy, PI1
Bertron, JL; Blakely, RD; Blobaum, AL; Dickerson, JW; Ennis, EA; Lindsley, CW; Locuson, CW; Rook, JM; Tarr, CJ; Wright, J1
Chen, DQ; Ding, J; Geng, MY; Liu, HC; Shen, AJ; Shen, JK; Sun, JY; Wang, X; Wang, YQ; Xiong, B; Zhang, MM; Zheng, M1
Beresini, M; Blaquiere, N; Bravo, B; Brightbill, H; Castanedo, GM; Chen, J; Cui, HF; Eigenbrot, C; Everett, C; Feng, J; Godemann, R; Gogol, E; Hymowitz, S; Johnson, A; Kayagaki, N; Knüppel, K; Kohli, PB; Kraemer, J; Krüger, S; Loke, P; McEwan, P; Montalbetti, C; Roberts, DA; Smith, M; Staben, ST; Steinbacher, S; Sujatha-Bhaskar, S; Takahashi, R; Wang, X; Wu, LC; Zhang, Y1
Cheng, C; Jia, Y; Jin, X; Liu, Y; Wang, G; Yao, L; Zhang, J; Zhou, F1
Lv, W; Wang, Y; Zhang, M; Zhang, Y1
Fu, Y; Gao, S; Kang, T; Li, JJ; Wu, SL; Ye, F; Zhai, Y; Zhao, LX1
Rajan, R; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B1
Bąchor, U; Brożyna, M; Junka, A; Mączyński, M1

Reviews

17 review(s) available for oxazoles and isoxazoles

ArticleYear
Mitigating heterocycle metabolism in drug discovery.
    Journal of medicinal chemistry, 2012, Jul-12, Volume: 55, Issue:13

    Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats

2012
Broxaterol: pharmacological profile of a unique structural feature.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 2

    Topics: Adrenergic beta-Agonists; Animals; Asthma; Bronchodilator Agents; Humans; Isoxazoles; Oxazoles; Structure-Activity Relationship

1989
Role of broxaterol in bronchial hyperresponsiveness.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 2

    Topics: Adrenergic beta-Agonists; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Bronchodilator Agents; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic

1989
Broxaterol: therapeutic trials and safety profile.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 2

    Topics: Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Child; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic

1989
GABA uptake inhibitors: relevance to antiepileptic drug research.
    Epilepsy research, 1987, Volume: 1, Issue:2

    Topics: Animals; Anticonvulsants; Brain; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Neurotransmitter Uptake Inhibitors; Oxazoles

1987
Neuropharmacology of zonisamide, a new antiepileptic drug.
    General pharmacology, 1987, Volume: 18, Issue:3

    Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Carbonic Anhydrase Inhibitors; Drug Interactions; Epilepsy; Isoxazoles; Kinetics; Oxazoles; Zonisamide

1987
Acivicin in 1985.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Humans; Isoxazoles; Kinetics; Male; Nervous System; Oxazoles

1985
THIP, isoguvacine, isoguvacine oxide, and related GABA agonists.
    Advances in biochemical psychopharmacology, 1981, Volume: 29

    Topics: Animals; Autoradiography; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Oxazoles; Pipecolic Acids; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution

1981
Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure.
    Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1981, Volume: 35, Issue:5

    Topics: Agaricales; Amanita; Animals; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Structural; Molecular Conformation; Muscimol; Nipecotic Acids; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism

1981
Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.
    Pharmaceutisch weekblad. Scientific edition, 1982, Oct-22, Volume: 4, Issue:5

    Topics: Analgesics; Animals; Brain; gamma-Aminobutyric Acid; Humans; Isoxazoles; Methylphenidate; Neurons; Oxazoles; Stereotyped Behavior; Synaptic Transmission

1982
Acivicin. An antitumor antibiotic.
    Cancer clinical trials, 1981,Fall, Volume: 4, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Glycine; Humans; Isoxazoles; Neoplasms; Neoplasms, Experimental; Oxazoles

1981
The treatment of rhinovirus infections: progress and potential.
    Antiviral research, 2001, Volume: 49, Issue:1

    Topics: 3C Viral Proteases; Antiviral Agents; Clinical Trials as Topic; Combined Modality Therapy; Common Cold; Cysteine Endopeptidases; Dietary Supplements; Drug Therapy, Combination; Echinacea; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Phytotherapy; Picornaviridae Infections; Plant Extracts; Plants, Medicinal; Pyrrolidinones; Receptors, Virus; Rhinovirus; Valine; Viral Proteins; Zinc

2001
Biotransformation reactions of five-membered aromatic heterocyclic rings.
    Chemical research in toxicology, 2002, Volume: 15, Issue:3

    Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics

2002
RECENT DEVELOPMENTS IN ISOXAZOLE CHEMISTRY.
    Advances in heterocyclic chemistry, 1963, Volume: 18

    Topics: Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles

1963
An integrated approach to developing chemoenzymatic processes at the industrial scale.
    Ernst Schering Foundation symposium proceedings, 2006, Issue:3

    Topics: Bacillus; Biotechnology; Biotransformation; Catalysis; Chemistry, Pharmaceutical; Cost-Benefit Analysis; Drug Design; Enzymes; Fructose-Bisphosphate Aldolase; HIV Protease Inhibitors; Isoxazoles; Models, Chemical; Models, Theoretical; Oxazoles; Pharmaceutical Preparations; Phenylalanine; Pyrrolidines; Pyrrolidinones; Stereoisomerism; Valine

2006
Michael acceptors as cysteine protease inhibitors.
    Mini reviews in medicinal chemistry, 2007, Volume: 7, Issue:10

    Topics: Animals; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoxazoles; Leucine; Molecular Structure; Oxazoles; Peptides; Phenylalanine; Pyrrolidines; Pyrrolidinones; Structure-Activity Relationship; Sulfones; Valine

2007
Chemical synthesis of heterocyclic-sugar nucleoside analogues.
    Chemical reviews, 2010, Jun-09, Volume: 110, Issue:6

    Topics: Carbohydrates; Dioxolanes; Heterocyclic Compounds; Isoxazoles; Nucleosides; Oxazoles; Pyrrolidines; Sulfhydryl Compounds; Sulfides; Thiazolidines

2010

Trials

25 trial(s) available for oxazoles and isoxazoles

ArticleYear
Huntington's disease: treatment with muscimol, a GABA-mimetic drug.
    Transactions of the American Neurological Association, 1977, Volume: 102

    Topics: Amanita; Betaine; Clinical Trials as Topic; Double-Blind Method; Humans; Huntington Disease; Isoxazoles; Oxazoles

1977
[Clinical trial of a new non-steroidal anti-inflammatory analgesic, 31252-S, for postoperative pain following tooth extraction and minor ambulatory surgery].
    Shikai tenbo = Dental outlook, 1979, Volume: 53, Issue:6

    Topics: Adolescent; Adult; Aged; Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Epirizole; Female; Humans; Isoxazoles; Male; Middle Aged; Minor Surgical Procedures; Mouth; Oxazoles; Pain, Postoperative; Periodontal Cyst; Piperidines; Placebos; Tooth Extraction

1979
Broxaterol, a new beta 2-adrenoceptor agonist compared to salbutamol in asthmatics, oral and inhalation treatment.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 2

    Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Albuterol; Asthma; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic

1989
Role of broxaterol in bronchial hyperresponsiveness.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 2

    Topics: Adrenergic beta-Agonists; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Bronchodilator Agents; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic

1989
Broxaterol: therapeutic trials and safety profile.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 2

    Topics: Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Child; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic

1989
Phase II trial of continuous drug infusions in advanced ovarian carcinoma: acivicin versus vinblastine.
    Investigational new drugs, 1989, Volume: 7, Issue:2-3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Infusions, Intravenous; Isoxazoles; Middle Aged; Ovarian Neoplasms; Oxazoles

1989
Broxaterol: a double-blind clinical trial comparing broxaterol and salbutamol.
    Respiration; international review of thoracic diseases, 1985, Volume: 47, Issue:4

    Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Blood Pressure; Bronchitis; Clinical Trials as Topic; Double-Blind Method; Female; Forced Expiratory Volume; Heart Rate; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Pulse; Random Allocation; Spirometry; Time Factors

1985
GABA-agonist therapy for Alzheimer's disease.
    Clinical neuropharmacology, 1986, Volume: 9, Issue:3

    Topics: Alzheimer Disease; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Isoxazoles; Middle Aged; Neuropsychological Tests; Oxazoles; Somatostatin

1986
Evaluation of a new bronchodilating compound (broxaterol) administered as a pressurized aerosol.
    International journal of clinical pharmacology, therapy, and toxicology, 1987, Volume: 25, Issue:2

    Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aged; Asthma; Bronchi; Bronchitis; Bronchospirometry; Double-Blind Method; Drug Evaluation; Forced Expiratory Volume; Humans; Isoxazoles; Maximal Midexpiratory Flow Rate; Middle Aged; Oxazoles; Random Allocation; Vital Capacity

1987
Broxaterol (Z.1170), a new oral beta 2-agonist compared with salbutamol.
    Respiration; international review of thoracic diseases, 1987, Volume: 51, Issue:2

    Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Double-Blind Method; Female; Hemodynamics; Humans; Isoxazoles; Lung Diseases, Obstructive; Male; Middle Aged; Oxazoles; Random Allocation; Respiratory Function Tests

1987
A comparison of the bronchodilator effects of broxaterol and salbutamol.
    International journal of clinical pharmacology, therapy, and toxicology, 1988, Volume: 26, Issue:2

    Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Blood Pressure; Bronchodilator Agents; Female; Heart Rate; Humans; Isoxazoles; Lung Diseases, Obstructive; Male; Middle Aged; Oxazoles; Respiratory Function Tests; Time Factors

1988
Early bronchodilating effect of a new oral beta-2-receptor agonist (broxaterol) in bronchial asthma.
    Respiration; international review of thoracic diseases, 1988, Volume: 53, Issue:4

    Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles

1988
Pharmacologic effects of A-56234, a new high-ceiling diuretic.
    Journal of clinical pharmacology, 1988, Volume: 28, Issue:9

    Topics: Adolescent; Adult; Chlorides; Diuresis; Diuretics; Double-Blind Method; Humans; Isoxazoles; Male; Oxazoles; Sodium; Uricosuric Agents

1988
Phase II evaluation of acivicin in lung cancer: a Southeastern Cancer Study Group Trial.
    Cancer treatment reports, 1986, Volume: 70, Issue:8

    Topics: Antibiotics, Antineoplastic; Carcinoma, Bronchogenic; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Oxazoles

1986
Phase II clinical trial of acivicin in advanced breast cancer: an Eastern Cooperative Oncology Group Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:10

    Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1986
Phase II trial of acivicin in advanced breast carcinoma: a Cancer and Leukemia Group B Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:10

    Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Brain Diseases; Breast Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1986
Pharmacokinetic and biochemical studies on acivicin in phase I clinical trials.
    Cancer research, 1985, Volume: 45, Issue:9

    Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Clinical Trials as Topic; Drug Evaluation; Female; Humans; Isoxazoles; Kinetics; Liver Diseases; Male; Oxazoles

1985
The effect of tetrahydroisoxazolopyridinol (THIP) in tardive dyskinesia: a new gamma-aminobutyric acid agonist.
    Archives of general psychiatry, 1982, Volume: 39, Issue:9

    Topics: Adult; Aged; Analgesics; Antipsychotic Agents; Blinking; Clinical Trials as Topic; Confusion; Dizziness; Dyskinesia, Drug-Induced; Female; Humans; Isoxazoles; Male; Mental Disorders; Middle Aged; Oxazoles; Parkinson Disease, Secondary; Placebos; Vomiting

1982
THIP treatment of Huntington's disease.
    Neurology, 1983, Volume: 33, Issue:5

    Topics: Adult; Clinical Trials as Topic; Disability Evaluation; Double-Blind Method; Female; Homovanillic Acid; Humans; Huntington Disease; Isoxazoles; Male; Middle Aged; Oxazoles

1983
Respiratory effect of THIP, a GABA-agonistic analgesic, during halothane anaesthesia.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:5

    Topics: Adolescent; Adult; Analgesics; Anesthesia, Inhalation; Clinical Trials as Topic; Halothane; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Respiration

1983
Therapeutic effects of GABA-ergic drugs in affective disorders. A preliminary report.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2

    Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Oxazoles; Oxcarbazepine; Schizophrenia; Valproic Acid

1983
THIP: a single-blind controlled trial in patients with epilepsy.
    Acta neurologica Scandinavica, 1983, Volume: 67, Issue:2

    Topics: Adult; Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles

1983
Analgesic from mushrooms begins clinical trials.
    Science (New York, N.Y.), 1981, Apr-24, Volume: 212, Issue:4493

    Topics: Analgesics; Clinical Trials as Topic; Humans; Isoxazoles; Oxazoles

1981
Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers.
    Antimicrobial agents and chemotherapy, 2002, Volume: 46, Issue:2

    Topics: Adult; Antiviral Agents; Double-Blind Method; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Valine

2002
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:12

    Topics: Administration, Inhalation; Adolescent; Adult; Antiviral Agents; Biological Availability; Common Cold; Double-Blind Method; Endpoint Determination; Female; Humans; Isoxazoles; Male; Middle Aged; Mucus; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Suspensions; Valine

2003

Other Studies

481 other study(ies) available for oxazoles and isoxazoles

ArticleYear
GABA-mediated control of rat neostriatal tyrosine hydroxylase revealed by intranigral muscimol.
    Nature, 1976, Oct-21, Volume: 263, Issue:5579

    Topics: Aminobutyrates; Animals; Bicuculline; Caudate Nucleus; Corpus Striatum; Dopamine; Enzyme Activation; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Neural Pathways; Olfactory Bulb; Oxazoles; Pimozide; Pteridines; Quaternary Ammonium Compounds; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase

1976
Pharmacological properties of 2,3-dihydro-9H-isoxazolo [3,2-b] quinazolin-9-one (W-2429. Part 1: Analgesic, antipyretic and antiedema activity.
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:4

    Topics: Administration, Oral; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Body Temperature; Dextropropoxyphene; Drug Interactions; Drug Tolerance; Edema; Fever; Humans; Injections, Intravenous; Isoxazoles; Lethal Dose 50; Male; Mice; Narcotic Antagonists; Oxazoles; Quinazolines; Rats; Substance-Related Disorders; Time Factors

1977
GABA-like properties of flurazepam and baclofen suggested by rotational behaviour following unilateral intranigral injection: a comparison with the GABA agonist muscimol [proceedings].
    British journal of pharmacology, 1977, Volume: 60, Issue:2

    Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Baclofen; Behavior; Flurazepam; gamma-Aminobutyric Acid; Humans; Injections; Isoxazoles; Male; Oxazoles; Rats; Stereotyped Behavior; Substantia Nigra

1977
5-Carboxamido-4-amino-3-isoxazolidone, and asparagine analogue.
    Journal of medicinal chemistry, 1978, Volume: 21, Issue:7

    Topics: Animals; Antineoplastic Agents; Aspartate-Ammonia Ligase; Carcinoma, Hepatocellular; Isoxazoles; Leukemia L1210; Leukemia, Experimental; Liver Neoplasms; Mice; Neoplasms, Experimental; Oxazoles; Oxazolidinones

1978
Proceedings: The presence of isoxazolin-5-one derivatives in root exudates of pea and sweet pea seedlings.
    Archives internationales de physiologie et de biochimie, 1976, Volume: 84, Issue:1

    Topics: Isoxazoles; Oxazoles; Plant Development; Plant Physiological Phenomena

1976
Oxonol dyes as monitors of membrane potential. Their behavior in photosynthetic bacteria.
    Biochimica et biophysica acta, 1979, Jan-11, Volume: 545, Issue:1

    Topics: Antimycin A; Bacterial Chromatophores; Carotenoids; Chromatium; Fluorescent Dyes; Isoxazoles; Kinetics; Light; Membrane Potentials; Oxazoles; Photosynthesis; Rhodobacter sphaeroides; Rhodospirillum rubrum; Spectrophotometry; Structure-Activity Relationship

1979
The disposition of 3-methyl-2,3-dihydro-9H-isoxazolo[3,2-b]-quinazolin-9-one (W-2451).
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 239, Issue:2

    Topics: Analgesics; Animals; Biotransformation; Blood Proteins; Dogs; Haplorhini; Humans; In Vitro Techniques; Isoxazoles; Liver; Male; Oxazoles; Quinazolines; Rats; Species Specificity; Time Factors; Tissue Distribution

1979
Relationships between plasma concentrations of diphenylhydantoin, phenobarbital, carbamazepine, and 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810), a new anticonvulsant agent, and their anticonvulsant or neurotoxic effects in experimental animals.
    Epilepsia, 1979, Volume: 20, Issue:6

    Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Dogs; Dose-Response Relationship, Drug; Haplorhini; Isoxazoles; Male; Mice; Motor Skills; Oxazoles; Phenobarbital; Phenytoin; Rabbits; Rats; Seizures; Species Specificity

1979
Urinary metabolites of 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole in the dog.
    Journal of pharmaceutical sciences, 1979, Volume: 68, Issue:9

    Topics: Animals; Antiprotozoal Agents; Biotransformation; Chagas Disease; Chromatography, Gas; Dogs; Female; Isoxazoles; Mass Spectrometry; Mice; Nitroimidazoles; Oxazoles; Salmonella

1979
A new class of GABA agonist.
    Nature, 1977, Jul-07, Volume: 268, Issue:5615

    Topics: Action Potentials; Aminobutyrates; Animals; Bicuculline; Biological Transport; Cats; gamma-Aminobutyric Acid; Interneurons; Isonicotinic Acids; Isoxazoles; Molecular Conformation; Neural Inhibition; Oxazoles; Receptors, Neurotransmitter; Spinal Cord; Structure-Activity Relationship; Synaptic Transmission

1977
Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex.
    Proceedings of the National Academy of Sciences of the United States of America, 1977, Volume: 74, Issue:8

    Topics: Alkaloids; Animals; Cerebellar Cortex; Cyclic GMP; Diazepam; Haloperidol; Harmaline; Isoxazoles; Male; Morphine; Oxazoles; Purkinje Cells; Pyridines; Rats

1977
Muscimol binding in rat brain: association with synaptic GABA receptors.
    Brain research, 1978, Jun-09, Volume: 148, Issue:1

    Topics: Aminobutyrates; Animals; Binding Sites; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Polyethylene Glycols; Rats; Receptors, Neurotransmitter; Sodium

1978
Use of 3H-muscimol for GABA receptor studies.
    Nature, 1978, Jun-01, Volume: 273, Issue:5661

    Topics: Aminobutyrates; Animals; Bicuculline; Binding, Competitive; Brain; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Oxazoles; Potassium; Rats; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes

1978
GABA agonists and potential antagonists related to muscimol.
    Brain research, 1979, Nov-16, Volume: 177, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Receptors, Neurotransmitter; Stereotyped Behavior; Substantia Nigra

1979
Kinetics of the potential-sensitive extrinsic probe oxonol VI in beef heart submitochondrial particles.
    The Journal of membrane biology, 1979, Volume: 46, Issue:3

    Topics: Adenosine Triphosphate; Animals; Calibration; Cattle; Cell Membrane Permeability; Fluorescent Dyes; Intracellular Membranes; Isoxazoles; Kinetics; Mitochondria, Heart; NAD; Oxazoles; Oxygen; Spectrum Analysis; Valinomycin

1979
The behavior of oxonol dyes in phospholipid dispersions.
    Biophysical journal, 1979, Volume: 25, Issue:1

    Topics: Alkenes; Cholesterol; Fluorescent Dyes; Isoxazoles; Kinetics; Lipid Bilayers; Oxazoles; Phospholipids; Pulmonary Surfactants; Sonication; Spectrophotometry

1979
Absorption, distribution and metabolic fate of 2,3-dihydro-9H-isoxazolo-[3,2-b]quinazolin-9-one (W2429).
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:4

    Topics: Administration, Oral; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Blood Proteins; Dogs; Humans; Intestinal Absorption; Isoxazoles; Kinetics; Male; Mice; Oxazoles; Protein Binding; Quinazolines; Rats

1977
Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acute and subacute toxicity in mice, rats and dogs.
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Blood Chemical Analysis; Body Weight; Dogs; Female; Isoxazoles; Lethal Dose 50; Male; Mice; Organ Size; Oxazoles; Quinazolines; Rats; Spermatogenesis; Time Factors

1977
Absorption, excretion, distribution and metabolism of perisoxal in rats.
    Chemical & pharmaceutical bulletin, 1979, Volume: 27, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Intestinal Absorption; Isoxazoles; Male; Oxazoles; Rats; Tissue Distribution

1979
Studies in potential organo-fluorine antibacterial agents. Part 2: Synthesis and antibacterial activity of some new fluorine-containing 3.5-disubstituted isoxazoles.
    Die Pharmazie, 1979, Volume: 34, Issue:2

    Topics: Anti-Bacterial Agents; Escherichia coli; Isoxazoles; Oxazoles; Staphylococcus; Streptococcus

1979
Studies in potential organo-fluorine antibacterial agents. Part 3: Synthesis and antibacterial activity of some new fluorine containing 2,4,5-trisubstituted isoxazoles.
    Die Pharmazie, 1979, Volume: 34, Issue:9

    Topics: Anti-Bacterial Agents; Bacteria; Escherichia coli; Fluorine; Isoxazoles; Oxazoles; Staphylococcus; Structure-Activity Relationship

1979
Pharmacological properties of 2,3-dihydro-9H-isoxazolo[3,2-b]-quinazolin-9-one (W-2429. Part 2: General pharmacological investigation.
    Arzneimittel-Forschung, 1977, Volume: 27, Issue:4

    Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Antitussive Agents; Cats; Diuresis; Dogs; Enzyme Induction; Female; Gastrointestinal Hemorrhage; Gastrointestinal Motility; Guinea Pigs; Hemodynamics; Isoxazoles; Male; Mice; Motor Activity; Muscle Contraction; Muscle, Smooth; Oxazoles; Postural Balance; Prostaglandin-Endoperoxide Synthases; Quinazolines; Rabbits; Rats; Respiration; Sleep; Stomach Ulcer; Time Factors

1977
Effects of antiprogesterone on pregnancy. I. Midpregnancy.
    American journal of obstetrics and gynecology, 1979, Jan-15, Volume: 133, Issue:2

    Topics: Administration, Oral; Animals; Drug Evaluation, Preclinical; Estradiol; Female; Fetal Death; Fetus; Isoxazoles; Oxazoles; Pregnancy; Pregnancy Trimester, Third; Pregnancy, Animal; Progesterone; Prostaglandins F; Radioimmunoassay; Rats; Uterus

1979
Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
    Cancer research, 1979, Volume: 39, Issue:3

    Topics: 3-Deazauridine; Animals; Antibiotics, Antineoplastic; Drug Resistance; Female; Glycine; Isoxazoles; Lethal Dose 50; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Nucleotides; Oxazoles; Sex Factors

1979
Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125.
    Cancer treatment reports, 1979, Volume: 63, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycine; Humans; Isoxazoles; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Oxazoles; Transplantation, Heterologous

1979
Charge transfer during Ca2+ uptake by rabbit skeletal muscle sarcoplasmic reticulum vesicles as measured with oxanol VI.
    FEBS letters, 1979, Apr-15, Volume: 100, Issue:2

    Topics: Animals; Calcium; Cell-Free System; Coloring Agents; Female; Isoxazoles; Membrane Potentials; Oxazoles; Rabbits; Sarcoplasmic Reticulum

1979
Induction of preterm labor in the rat by antiprogesterone.
    American journal of obstetrics and gynecology, 1979, Aug-01, Volume: 134, Issue:7

    Topics: Administration, Oral; Animals; Estradiol; Female; Injections, Intramuscular; Isoxazoles; Labor, Induced; Oxazoles; Pregnancy; Progesterone; Progesterone Congeners; Prostaglandins F; Rats; Uterus

1979
Enhanced effect of an L-glutamine antagonist, L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, by Acinetobacter L-glutaminase-L-asparaginase.
    Cancer treatment reports, 1979, Volume: 63, Issue:6

    Topics: Acinetobacter; Amino Acids; Animals; Asparaginase; Carcinoma, Ehrlich Tumor; Drug Synergism; Drug Therapy, Combination; Female; Glutaminase; Glutamine; Glycine; Isoxazoles; Lethal Dose 50; Leukemia L1210; Male; Mice; Oxazoles

1979
Pharmacokinetic and pharmacodynamic tolerance of a new anticonvulsant agent (3-sulfamoylmethyl-1,2-benzisoxazole) compared to phenobarbital, diphenylhydantoin and carbamazepine in rats.
    Archives internationales de pharmacodynamie et de therapie, 1979, Volume: 240, Issue:1

    Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Hexobarbital; Isoxazoles; Kinetics; Male; Oxazoles; Phenobarbital; Phenytoin; Proadifen; Rats; Sleep; Time Factors

1979
THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.
    European journal of pharmacology, 1979, Oct-15, Volume: 58, Issue:4

    Topics: Animals; Benzodiazepines; Cerebral Cortex; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Drug

1979
Conformational analysis of muscimol, a GABA agonist.
    Journal of theoretical biology, 1979, Aug-07, Volume: 79, Issue:3

    Topics: Bicuculline; Binding Sites; gamma-Aminobutyric Acid; Isoxazoles; Models, Molecular; Molecular Conformation; Muscimol; Oxazoles; Quantum Theory

1979
[Central effect of new benzoxazoline-2 and 3-hydroxybenzisoxazole derivatives].
    Acta poloniae pharmaceutica, 1979, Volume: 36, Issue:2

    Topics: Animals; Benzoxazoles; Body Temperature; Chemical Phenomena; Chemistry; Female; Isoxazoles; Male; Mice; Motor Activity; Nociceptors; Oxazoles; Sleep

1979
Potential antiinflammatory compounds. 2. Acidic antiinflammatory 1,2-benzisoxazoles.
    Journal of medicinal chemistry, 1979, Volume: 22, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Isoxazoles; Oxazoles; Rats; Structure-Activity Relationship

1979
New CNS-active 3-methyl-4-substituted methyl-delta 2-isoxazolin-5-ones.
    Die Pharmazie, 1979, Volume: 34, Issue:10

    Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Female; Isoxazoles; Male; Mice; Monoamine Oxidase Inhibitors; Oxazoles; Pentobarbital; Rats; Sleep; Time Factors

1979
Does uptake limit the actions of GABA agonists in vivo? Experiments with muscimol, isoguvacine and THIP in cat spinal cord.
    Journal of neurochemistry, 1978, Volume: 31, Issue:6

    Topics: Aminobutyrates; Animals; Biological Transport; Cats; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons; Nipecotic Acids; Oxazoles; Spinal Cord

1978
Rotational behaviour after unilateral intranigral injection of muscimol in rats.
    European journal of pharmacology, 1977, Jun-15, Volume: 43, Issue:4

    Topics: Aminobutyrates; Animals; Basidiomycota; Behavior; Bicuculline; gamma-Aminobutyric Acid; Humans; Injections; Isoxazoles; Male; Oxazoles; Picrotoxin; Rats; Stereotyped Behavior; Substantia Nigra; Time Factors

1977
Muscimol a GABA-agonist injected into the nucleus accumbens increases apomorphine stereotypy and decreases the motility.
    Life sciences, 1977, Dec-01, Volume: 21, Issue:11

    Topics: Aminobutyrates; Animals; Apomorphine; Basidiomycota; Behavior; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Motor Activity; Nucleus Accumbens; Oxazoles; Rats; Septal Nuclei; Stereotyped Behavior

1977
The action of muscimol on neurones of the substantia nigra of the rat.
    Experientia, 1978, Feb-15, Volume: 34, Issue:2

    Topics: Animals; Basidiomycota; Corpus Striatum; Electric Stimulation; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Male; Neural Inhibition; Neurons; Oxazoles; Rats; Substantia Nigra

1978
Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: a complex GABA-dopamine interaction.
    Life sciences, 1978, Volume: 22, Issue:1

    Topics: Animals; Apomorphine; Basidiomycota; Behavior; Cocaine; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Methylphenidate; Methyltyrosines; Mice; Motor Activity; Oxazoles; Stereotyped Behavior

1978
Effect of muscimol on single unit activity of substantia nigra dopamine neurons.
    European journal of pharmacology, 1978, Feb-15, Volume: 47, Issue:4

    Topics: Anesthesia; Animals; Basidiomycota; Dopamine; Isoxazoles; Male; Neurons; Oxazoles; Rats; Substantia Nigra; Time Factors

1978
Muscimol, GABA and picrotoxin: effects on membrane conductance of a crustacean neuron.
    Brain research, 1978, Feb-10, Volume: 141, Issue:2

    Topics: Aminobutyrates; Animals; Astacoidea; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Mechanoreceptors; Membrane Potentials; Mycotoxins; Neural Inhibition; Neurons; Oxazoles; Picrotoxin; Receptors, Drug; Synaptic Membranes

1978
GABA receptor binding with 3H-muscimol in calf cerebellum.
    European journal of pharmacology, 1978, Apr-01, Volume: 48, Issue:3

    Topics: Aminobutyrates; Animals; Bicuculline; Cattle; Cerebellum; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Kinetics; Oxazoles; Receptors, Drug

1978
Determination of 1,2-benzisoxazole-3-acetamidoxime hydrochloride (PE-257) in plasma using electron-capture gas chromatography.
    Journal of chromatography, 1978, Mar-11, Volume: 150, Issue:1

    Topics: Animals; Chromatography, Gas; Isoxazoles; Oxazoles; Oximes; Psychotropic Drugs; Rats

1978
Muscimol antagonizes morphine hypermotility without potentiation of analgesia.
    European journal of pharmacology, 1978, Apr-15, Volume: 48, Issue:4

    Topics: Analgesia; Analgesics; Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Neuromuscular Blocking Agents; Oxazoles

1978
Effects of multiple treatments of isoxicam on organ weights and serum SGPT, AP, and BUN in adjuvant-induced polyarthritic rats.
    Research communications in chemical pathology and pharmacology, 1978, Volume: 19, Issue:3

    Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Arthritis; Arthritis, Experimental; Blood Urea Nitrogen; Isoxazoles; Male; Organ Size; Oxazoles; Piroxicam; Rats; Thiazines

1978
Nipecotic acid and 2,4-diaminobutyric acid enhance the actions of muscimol on cerebral cortical neurons.
    Canadian journal of physiology and pharmacology, 1978, Volume: 56, Issue:3

    Topics: Action Potentials; Amino Acids, Diamino; Aminobutyrates; Animals; Cerebral Cortex; Drug Synergism; Female; gamma-Aminobutyric Acid; Isoxazoles; Mycotoxins; Neurons; Nipecotic Acids; Oxazoles; Rats

1978
Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds.
    Journal of neurochemistry, 1978, Volume: 30, Issue:6

    Topics: Aminobutyrates; Animals; Brain; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Structure-Activity Relationship; Synaptic Membranes

1978
Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
    Advances in enzyme regulation, 1978, Volume: 17

    Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line; Cell Survival; Female; Glutamine; Glycine; Isoxazoles; Leukemia L1210; Leukemia P388; Macromolecular Substances; Male; Mice; Oxazoles; Sex Factors; Thymidine; Uridine; Valine

1978
Inactivation of Bacillus cereus beta-lactamase by halogenated isoxazolylpenicillins.
    European journal of biochemistry, 1976, Feb-02, Volume: 62, Issue:1

    Topics: Bacillus cereus; beta-Lactamase Inhibitors; Dicloxacillin; Isoxazoles; Kinetics; Mathematics; Oxazoles; Penicillins; Structure-Activity Relationship; Temperature; Time Factors

1976
Novel pyrazolo, isoxazolo, and thiazolo steroidal systems and model analogs containing dimethyoxylaryl (or dihydroxylaryl) groups and derivatives. Synthesis, spectral properties, and biological activity.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:2

    Topics: Bacillus subtilis; Cells, Cultured; Depression, Chemical; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pseudomonas fluorescens; Pyrazoles; Spectrophotometry, Infrared; Staphylococcus aureus; Steroids, Heterocyclic; Thiazoles

1976
Synthesis and structure-activity relationships of heterocyclic compounds containing a trimethoxyarene function.
    Journal of medicinal chemistry, 1976, Volume: 19, Issue:2

    Topics: Bacillus subtilis; Cells, Cultured; Depression, Chemical; Humans; Isoxazoles; Methyl Ethers; Microbial Sensitivity Tests; Naphthalenes; Oxazoles; Phenanthrenes; Pseudomonas fluorescens; Pyrazoles; Structure-Activity Relationship

1976
Association of halogenated isoxazolylpenicillins with penicillinase-sensitive beta-lactam antibiotics. Microbiological evaluation on beta-lactamase-producing Enterobacteriaceae.
    Chemotherapy, 1977, Volume: 23, Issue:3

    Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Enterobacteriaceae; Halogens; Isoxazoles; Mice; Microbial Sensitivity Tests; Oxazoles; Penicillinase; Penicillins

1977
Potentiation of morphine analgesia by muscimol.
    Neuropharmacology, 1977, Volume: 16, Issue:2

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Synergism; Isoxazoles; Mice; Morphine; Oxazoles; Quaternary Ammonium Compounds; Rats

1977
Muscimol antagonizes the ergometrine-induced locomotor activity in nucleus accumbens: evidence for a GABA--dopaminergic interaction.
    European journal of pharmacology, 1977, Apr-07, Volume: 42, Issue:3

    Topics: Aminobutyrates; Animals; Dopamine; Ergonovine; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Olfactory Bulb; Oxazoles; Rats; Time Factors

1977
Polarographic study of new antibacterial isoxazolium salts: 2,3-dialkyl-5-arylisoxazolium perchlorates.
    Journal of pharmaceutical sciences, 1977, Volume: 66, Issue:4

    Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Oxidation-Reduction; Polarography; Staphylococcus aureus; Structure-Activity Relationship

1977
Isoxazole anthelmintics.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:7

    Topics: Animals; Anthelmintics; Hookworm Infections; Isoxazoles; Nippostrongylus; Oxazoles; Rats; Structure-Activity Relationship

1977
3-hydroxyisoxazole-5-hydroxamic acid.
    Journal of medicinal chemistry, 1977, Volume: 20, Issue:7

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Fungi; Hydroxamic Acids; Isoxazoles; Leukemia L1210; Leukemia, Experimental; Mice; Microbial Sensitivity Tests; Oxazoles

1977
Effect of muscimol, a GABA-mimetic agent, on dopamine metabolism in the mouse brain.
    Life sciences, 1977, Aug-15, Volume: 21, Issue:4

    Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Aminobutyrates; Animals; Brain; Caudate Nucleus; Diazepam; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Homovanillic Acid; Isoxazoles; Male; Mice; Motor Activity; Oxazoles; Phenobarbital

1977
[Nitrones, VIII. Isoxazolidine-compounds, VII: Reformatzky reaction with ketonitrones. Slow N-inversion in the 5-isoxazolidinone ring (author's transl)].
    Archiv der Pharmazie, 1977, Volume: 310, Issue:11

    Topics: Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Nitrogen Oxides; Oxazoles; Time Factors

1977
3-Isoxazolidone--an inhibitor of GABA metabolism.
    Biochemical pharmacology, 1976, Jul-15, Volume: 25, Issue:14

    Topics: Aminobutyrates; Animals; Brain; Chickens; Depression, Chemical; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Isoniazid; Isoxazoles; Male; Mice; Oxazoles; Oxazolidinones; Rats; Seizures; Time Factors

1976
Preparation of tri- and tetramethyleneisoxazoles.
    Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:9

    Topics: Cyclization; Isoxazoles; Oxazoles

1976
The in vitro metabolism of 3-(1-hydroxy-2-piperidinoethyl)-5-phenyl-isoxazole citrate (31252-S) with rabbit liver homogenate.
    Chemical & pharmaceutical bulletin, 1976, Volume: 24, Issue:8

    Topics: Animals; In Vitro Techniques; Isoxazoles; Kinetics; Liver; Male; Mice; Oxazoles; Piperidines; Rabbits

1976
Synthesis, structure determination, spectral properties, and energy-linked spectral responses of the extrinsic probe oxonol V in membranes.
    Biochemistry, 1976, Nov-16, Volume: 15, Issue:23

    Topics: Animals; Binding Sites; Cell Membrane; Columbidae; Energy Transfer; Isoxazoles; Magnetic Resonance Spectroscopy; Membranes; Membranes, Artificial; Mitochondria, Muscle; Molecular Conformation; Myocardium; Oxazoles; Potassium; Spectrometry, Fluorescence; Spectrophotometry

1976
Regional changes in the rate of turnover of acetylcholine in rat brain following diazepam or muscimol.
    Naunyn-Schmiedeberg's archives of pharmacology, 1976, Volume: 294, Issue:3

    Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Male; Oxazoles; Quaternary Ammonium Compounds; Rats; Receptors, Drug

1976
Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.
    Agents and actions, 1976, Volume: 6, Issue:6

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Body Weight; Dextropropoxyphene; Drug Therapy, Combination; Isoxazoles; Male; Organ Size; Oxazoles; Piroxicam; Rats; Thiazines

1976
[Nitrones. 6. Isoxazolidine compounds. 6. Malonic ester addition of nitrones with large N-substituents].
    Archiv der Pharmazie, 1976, Volume: 309, Issue:11

    Topics: Chemical Phenomena; Chemistry; Isoxazoles; Malonates; Nitrogen Oxides; Oxazoles

1976
[Condensation of 2,3-dimethyl-4-carbetoxyisoxazoline-5-one with aromatic aldehydes].
    Bollettino chimico farmaceutico, 1976, Volume: 115, Issue:8

    Topics: Aldehydes; Isoxazoles; Oxazoles; Spectrophotometry, Ultraviolet

1976
Effects of 1,2-benzisoxazole-3-acetamidoxime on central monoamine neurons in the rat.
    Chemical & pharmaceutical bulletin, 1976, Volume: 24, Issue:11

    Topics: Animals; Biogenic Amines; Brain; Brain Chemistry; Isoxazoles; Levodopa; Male; Neurons; Oxazoles; Oximes; Psychotropic Drugs; Rats

1976
[Nitrones. 7. Synthesis of an isoxazoline by dimerization of a C-methylnitrone].
    Archiv der Pharmazie, 1976, Volume: 309, Issue:12

    Topics: Chemical Phenomena; Chemistry; Isoxazoles; Nitrogen Oxides; Oxazoles

1976
Effect of 1,2-benzisoxazole-3-acetamidoxime on caudato-thalamo-cortical system in cats.
    Chemical & pharmaceutical bulletin, 1976, Volume: 24, Issue:12

    Topics: Animals; Cats; Caudate Nucleus; Cerebral Cortex; Electroencephalography; Female; Isoxazoles; Male; Oxazoles; Oximes; Seizures; Thalamus

1976
Absorption, distribution, and metabolic fate of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one in rats, dogs, and humans.
    Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:8

    Topics: Animals; Anti-Inflammatory Agents; Dogs; Drug Stability; Humans; In Vitro Techniques; Intestinal Absorption; Isoxazoles; Male; Oxazines; Oxazoles; Protein Binding; Radioisotope Dilution Technique; Rats; Salicylates; Time Factors

1975
Treatment of endometriosis with Danazol.
    American journal of obstetrics and gynecology, 1975, Jan-15, Volume: 121, Issue:2

    Topics: Adult; Castration; Endometriosis; Ethisterone; Fallopian Tubes; Female; Humans; Hysterectomy; Isoxazoles; Neoplasm Metastasis; Neoplasm Recurrence, Local; Ovarian Neoplasms; Oxazoles; Uterine Neoplasms

1975
[Structure-activity relationship in histamine analogs. 10. 3-(2-aminoethyl)isoxazole, a ring analog of histamine].
    Archiv der Pharmazie, 1975, Volume: 308, Issue:1

    Topics: Ethylamines; Histamine; Isoxazoles; Oxazoles; Structure-Activity Relationship

1975
The isolation, structure, and absolute configuration of U-43,795, a new antitumor agent.
    The Journal of antibiotics, 1975, Volume: 28, Issue:1

    Topics: Amino Acids; Antimetabolites, Antineoplastic; Chemical Phenomena; Chemistry; Glycine; Isoxazoles; Molecular Conformation; Molecular Weight; Oxazoles; Streptomyces

1975
C-glycosyl nucleosides. VI. Synthesis of several 3- and 5-(beta-D-ribofuranosyl)isoxazoles.
    The Journal of organic chemistry, 1975, Jul-25, Volume: 40, Issue:15

    Topics: Isoxazoles; Methods; Oxazoles; Ribonucleosides; Temperature

1975
Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats.
    Journal of pharmaceutical sciences, 1975, Volume: 64, Issue:8

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Body Temperature; Edema; Isoxazoles; Male; Oxazines; Oxazoles; Rats; Salicylates; Stomach Ulcer

1975
Improved methods for production, isolation, and assay of two new chlorisoxazoline amino acid antitumor antimetabolites: U-42, 126 and U43, 795.
    Antimicrobial agents and chemotherapy, 1975, Volume: 7, Issue:6

    Topics: Antibiotics, Antineoplastic; Antimetabolites; Glycine; Isoxazoles; Methods; Oxazoles

1975
Induced adrenal and ovarian enlargement in nursing mothers by a single mug injection to their pups of a 3beta-hydroxy-delta5-steroid oxidoreductase inhibitor.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1975, Volume: 149, Issue:4

    Topics: Adrenal Glands; Animals; Animals, Newborn; Female; Hydroxysteroid Dehydrogenases; Isoxazoles; Lactation; Ovary; Oxazoles; Pituitary Gland; Pregnancy; Progesterone Reductase; Rats

1975
[Isoxazolo(5.4-b)pyridines (author's transl)].
    Archiv der Pharmazie, 1975, Volume: 308, Issue:6

    Topics: Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pyridines; Spectrophotometry, Infrared

1975
[Isoxazoles substituted with 4-pyridyl and o-chlorophenyl radicals].
    Il Farmaco; edizione scientifica, 1975, Volume: 30, Issue:5

    Topics: Animals; Anticonvulsants; Chlorobenzenes; Drug Evaluation, Preclinical; Isoxazoles; Male; Muscles; Oxazoles; Pyridines; Rats

1975
[New isoxazol /5,4-b/ pyridine-3-acetic acids].
    Il Farmaco; edizione scientifica, 1975, Volume: 30, Issue:12

    Topics: Acetates; Anti-Inflammatory Agents; Isoxazoles; Oxazoles; Plant Growth Regulators; Pyridines

1975
Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds.
    Journal of neurochemistry, 1975, Volume: 25, Issue:6

    Topics: Aminobutyrates; Animals; Biological Transport, Active; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Kinetics; Nipecotic Acids; Oxazoles; Rats; Structure-Activity Relationship

1975
The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).
    Agents and actions, 1975, Volume: 5, Issue:3

    Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Inflammation; Isoxazoles; Male; Oxazoles; Peptic Ulcer; Piroxicam; Rats; Thiazines

1975
[Synthesis of naphthisoxazole derivatives. I. Synthesis of 4,5-dihydronaphth(2,1-d)isoxazole derivatives (author's transl)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1975, Volume: 95, Issue:7

    Topics: Isoxazoles; Naphthalenes; Oxazoles

1975
[Oxidant-drug induced hemolytic anemia in dogs].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1975, Volume: 71, Issue:7

    Topics: Aminopyrine; Anemia, Hemolytic; Animals; Bilirubin; Blood Cell Count; Blood Proteins; Dogs; Female; Glucosephosphate Dehydrogenase; Glutathione; Isoxazoles; Liver; Male; Methemoglobinemia; Osmotic Fragility; Oxazoles; Phenacetin; Phenylhydrazines; Piperidines; Spleen

1975
NMR determination of enantiomers of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one using chiral shift reagent, tris(3-(heptafluorobutyryl)-d-camphorato)europium(III).
    Journal of pharmaceutical sciences, 1976, Volume: 65, Issue:4

    Topics: Europium; Isoxazoles; Magnetic Resonance Spectroscopy; Methods; Oxazines; Oxazoles

1976
Two mechanisms by which fluorescent oxonols indicate membrane potential in human red blood cells.
    Biophysical journal, 1990, Volume: 57, Issue:4

    Topics: Benzenesulfonates; Erythrocyte Membrane; Erythrocytes; Fluorescent Dyes; Gramicidin; Hematocrit; Humans; Isoxazoles; Kinetics; Membrane Potentials; Models, Biological; Oxazoles; Potassium Chloride; Spectrometry, Fluorescence; Structure-Activity Relationship; Valinomycin

1990
The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of gamma-glutamyl transpeptidase inhibition.
    Toxicology and applied pharmacology, 1990, Mar-15, Volume: 103, Issue:1

    Topics: Animals; Catheterization; gamma-Glutamyltransferase; Glutathione; Hydroquinones; Isoxazoles; Kidney; Male; Oxazoles; Rats; Rats, Inbred Strains

1990
Competitive binding enzyme immunoassay for zonisamide, a new antiepileptic drug, with selected paired-enzyme labeled antigen and antibody.
    Clinical chemistry, 1990, Volume: 36, Issue:1

    Topics: Antibodies; Anticoagulants; Anticonvulsants; Antigens; beta-Galactosidase; Binding, Competitive; Chromatography, High Pressure Liquid; Cross Reactions; Galactosidases; Humans; Immune Sera; Immunoenzyme Techniques; Isoxazoles; Milk, Human; Oxazoles; Zonisamide

1990
Prolonged survival by tumor-bearing rats treated with acivicin and total parenteral nutrition.
    Journal of the National Cancer Institute, 1990, Mar-07, Volume: 82, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Combined Modality Therapy; Isoxazoles; Male; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Survival Rate

1990
[Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1990, Volume: 95, Issue:2

    Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Isoxazoles; Mice; Organ Size; Oxazoles; Platelet Aggregation Inhibitors; Rabbits; Rats

1990
Zonisamide-induced mania.
    Psychosomatics, 1990,Spring, Volume: 31, Issue:2

    Topics: Adult; Anticonvulsants; Bipolar Disorder; Dose-Response Relationship, Drug; Epilepsy, Post-Traumatic; Epilepsy, Temporal Lobe; Humans; Isoxazoles; Male; Oxazoles; Psychoses, Substance-Induced; Zonisamide

1990
4-Isoxazolyl-1,4-dihydropyridines: biological, theoretical, and structural studies.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:8

    Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Crystallization; Dihydropyridines; Guinea Pigs; Ileum; Isoxazoles; Isradipine; Molecular Conformation; Molecular Structure; Myocardium; Oxadiazoles; Oxazoles; Structure-Activity Relationship; X-Ray Diffraction

1990
Modulation of tolerance to the GABAA agonist THIP by environmental cues.
    Behavioural brain research, 1990, Jan-01, Volume: 36, Issue:1-2

    Topics: Animals; Anticonvulsants; Arousal; Association Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Tolerance; Exploratory Behavior; Isoxazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxazoles; Receptors, GABA-A; Social Environment

1990
A model for compounds active against human rhinovirus-14 based on X-ray crystallography data.
    Journal of medicinal chemistry, 1990, Volume: 33, Issue:5

    Topics: Antiviral Agents; Binding Sites; Capsid; Isoxazoles; Microbial Sensitivity Tests; Models, Molecular; Oxazoles; Rhinovirus; Structure-Activity Relationship; X-Ray Diffraction

1990
Disoxaril stabilization and immunogenicity of poliovirus procapsids.
    The Journal of general virology, 1990, Volume: 71 ( Pt 5)

    Topics: Animals; Antibodies, Viral; Antigens, Viral; Capsid; HeLa Cells; Humans; Hydrogen-Ion Concentration; Immunization; Isoxazoles; Mice; Mice, Inbred BALB C; Neutralization Tests; Oxazoles; Poliovirus; Protein Denaturation; Temperature; Virion

1990
Use of oxonol V as a probe of membrane potential in proteoliposomes containing cytochrome oxidase in the submitochondrial orientation.
    Biochemistry, 1990, Apr-24, Volume: 29, Issue:16

    Topics: Calibration; Cell Membrane; Cytochrome c Group; Electron Transport Complex IV; Isoxazoles; Lipid Bilayers; Liposomes; Membrane Potentials; Mitochondria; Oxazoles; Proteolipids; Spectrometry, Fluorescence

1990
Effects of inhibitors of protein synthesis and intracellular transport on the gamma-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells.
    Journal of neurochemistry, 1990, Volume: 55, Issue:4

    Topics: Animals; Anticonvulsants; Cell Differentiation; Cell Membrane; Cells, Cultured; Cerebellum; Colchicine; Cycloheximide; Dactinomycin; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Monensin; Oxazoles; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Receptors, GABA-A

1990
Effects of isoxazolyl-naphthoquinoneimines on growth and oxygen radical production in Trypanosoma cruzi and Crithidia fasciculata.
    Experientia, 1990, May-15, Volume: 46, Issue:5

    Topics: Animals; Antiprotozoal Agents; Crithidia; DNA; Free Radicals; Hydrogen Peroxide; Imines; Intracellular Membranes; Isoxazoles; Microsomes; Mitochondria; Naphthoquinones; Oxazoles; Oxygen; Trypanosoma cruzi

1990
Studies on antifungal agents. Novel cis-5-alkyl (or alkenyl)-3-phenyl-3-(1H-azol-1-ylmethyl)-2-methyl-isoxazolidine derivatives.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:2 Pt 1

    Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Isoxazoles; Microbial Sensitivity Tests; Oxazoles

1990
Mechanism of uricosuric action of AA-193 in DBA/2N mice.
    The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:2

    Topics: Animals; Inulin; Isoxazoles; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Oxazoles; Pyrazinamide; Species Specificity; Uric Acid; Uricosuric Agents

1990
Studies on antifungal agents. In vitro activity of novel cis-5-alkoxy (or acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine derivatives.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:1

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Oxazoles

1990
Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia.
    The Journal of biological chemistry, 1990, Jul-05, Volume: 265, Issue:19

    Topics: Animals; Azaserine; Azo Compounds; Carbon-Nitrogen Ligases; Cell Line; Chromatography, High Pressure Liquid; Diazooxonorleucine; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Isoxazoles; Leukemia L1210; Ligases; Mice; Nucleotides; Oxazoles; Spectrophotometry, Ultraviolet

1990
Anticonvulsant effects of zonisamide and phenytoin on seizure activity of the feline visual cortex.
    Brain & development, 1990, Volume: 12, Issue:2

    Topics: Animals; Anticonvulsants; Cats; Dose-Response Relationship, Drug; Epilepsy; Female; Isoxazoles; Kindling, Neurologic; Male; Oxazoles; Phenytoin; Visual Cortex; Zonisamide

1990
Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis.
    Biochemical and biophysical research communications, 1990, Jul-31, Volume: 170, Issue:2

    Topics: Animals; Antiprotozoal Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cells, Cultured; Enzyme Activation; Isoxazoles; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Oxazoles

1990
Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture.
    Cancer research, 1990, Sep-01, Volume: 50, Issue:17

    Topics: Amino Acids; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cats; Central Nervous System; Electrolytes; Female; Glucose; Humans; Infusions, Intravenous; Isoxazoles; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Mice, Nude; Oxazoles; Parenteral Nutrition Solutions; Reference Values; Solutions; Transplantation, Heterologous

1990
Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Oxazoles; Phosphoribosyl Pyrophosphate; Phosphotransferases

1985
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake.
    Diabetes, 1985, Volume: 34, Issue:7

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Diterpenes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Nifedipine; Oxazoles; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide; Verapamil

1985
Lymphocyte membrane potential and Ca2+-sensitive potassium channels described by oxonol dye fluorescence measurements.
    Journal of cellular physiology, 1985, Volume: 125, Issue:1

    Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcimycin; Calcium; Cell Membrane Permeability; Electrodes; Flow Cytometry; Fluorescent Dyes; Humans; Ion Channels; Isoxazoles; Lymphocytes; Mathematics; Membrane Potentials; Mice; Oxazoles; Potassium; Quinine; Trifluoperazine

1985
Enzyme targets of antiglutamine agents in cancer chemotherapy.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Anthranilate Synthase; Antibiotics, Antineoplastic; Azaserine; Drug Synergism; Glutamine; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nitrogenous Group Transferases; Oxazoles; Phosphoribosyl Pyrophosphate; Rats; Ribonucleotides; Transferases

1985
[Effect of Woodward's reagent K on tetrodotoxin-sensitive sodium channels of spinal ganglion neurons of the rat].
    Neirofiziologiia = Neurophysiology, 1986, Volume: 18, Issue:6

    Topics: Animals; Ganglia, Spinal; In Vitro Techniques; Ion Channels; Isoxazoles; Neurons, Afferent; Oxazoles; Ranvier's Nodes; Rats; Sodium; Tetrodotoxin

1986
Zonisamide enhances slow sodium inactivation in Myxicola.
    Brain research, 1987, Jun-09, Volume: 413, Issue:1

    Topics: Animals; Anticonvulsants; Axons; Ion Channels; Isoxazoles; Membrane Potentials; Oxazoles; Polychaeta; Potassium; Sodium; Zonisamide

1987
Oxonol VI as an optical indicator for membrane potentials in lipid vesicles.
    Biochimica et biophysica acta, 1987, Oct-16, Volume: 903, Issue:3

    Topics: Adsorption; Diffusion; Fluorescence; Fluorescent Dyes; Indicators and Reagents; Ion Channels; Isoxazoles; Liposomes; Membrane Potentials; Oxazoles; Phosphatidylcholines; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase; Solutions; Spectrometry, Fluorescence; Spectrophotometry; Valinomycin

1987
Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 244, Issue:2

    Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Conditioning, Psychological; Dogs; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Isoxazoles; Male; Motor Activity; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Risperidone; Serotonin Antagonists

1988
Biochemical profile of risperidone, a new antipsychotic.
    The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:2

    Topics: Animals; Antipsychotic Agents; Blood Platelets; Cerebral Cortex; Dopamine; Ergolines; Female; Haloperidol; Isoxazoles; Models, Molecular; Norepinephrine; Oxazoles; Phosphatidic Acids; Piperidines; Quinpirole; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Ritanserin; X-Ray Diffraction

1988
Differential effects of the new antipsychotic risperidone on large and small motor movements in rats: a comparison with haloperidol.
    Psychopharmacology, 1988, Volume: 95, Issue:4

    Topics: Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Haloperidol; Isoxazoles; Male; Motor Activity; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Risperidone

1988
Risperidone (R 64 766), a potent and complete LSD antagonist in drug discrimination by rats.
    Psychopharmacology, 1989, Volume: 97, Issue:2

    Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Stimulus; Isoxazoles; Lysergic Acid Diethylamide; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Risperidone

1989
Therapeutic effect and safety of increasing doses of risperidone (R 64766) in psychotic patients.
    Psychopharmacology, 1989, Volume: 99, Issue:4

    Topics: Adult; Aged; Antipsychotic Agents; Blood Pressure; Electrocardiography; Female; Hormones; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Piperidines; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone

1989
Receptor occupancy by ritanserin and risperidone measured using ex vivo autoradiography.
    Brain research, 1989, Oct-23, Volume: 500, Issue:1-2

    Topics: Animals; Brain; Dopamine Antagonists; Isoxazoles; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Ritanserin; Serotonin Antagonists

1989
Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.
    Neuropharmacology, 1989, Volume: 28, Issue:12

    Topics: Animals; Antipsychotic Agents; Isoxazoles; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Sleep; Wakefulness

1989
Zonisamide usage.
    Neurology, 1989, Volume: 39, Issue:5

    Topics: Epilepsies, Myoclonic; Humans; Isoxazoles; Kidney Calculi; Oxazoles; Zonisamide

1989
Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures.
    European journal of pharmacology, 1989, Sep-13, Volume: 168, Issue:2

    Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Isoniazid; Isoxazoles; Male; Nervous System; Neuroglia; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures

1989
Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril.
    The Journal of infectious diseases, 1989, Volume: 159, Issue:5

    Topics: Animals; Antiviral Agents; Brain; Cyclophosphamide; Disease Models, Animal; Drug Resistance, Microbial; Enterovirus Infections; Immunosuppression Therapy; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Oxazoles; Poliomyelitis; Poliovirus

1989
Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound.
    Journal of virology, 1989, Volume: 63, Issue:6

    Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HeLa Cells; Humans; Isoxazoles; Models, Molecular; Molecular Conformation; Molecular Structure; Mutation; Oxazoles; Rhinovirus; Viral Plaque Assay

1989
Evaluation and synthesis of aminohydroxyisoxazoles and pyrazoles as potential glycine agonists.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:9

    Topics: Animals; Brain; Chemical Phenomena; Chemistry; Detergents; Glycine; Isoxazoles; Models, Molecular; Oxazoles; Pyrazoles; Quaternary Ammonium Compounds; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Structure-Activity Relationship

1989
GABAergic drugs and lordosis behavior in the female rat.
    Hormones and behavior, 1989, Volume: 23, Issue:3

    Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Estradiol; Female; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Taurine

1989
In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:12

    Topics: Animals; Animals, Suckling; Antiviral Agents; Coxsackievirus Infections; Culture Media; Echovirus Infections; Female; Isoxazoles; Mice; Mice, Inbred ICR; Oxazoles; Picornaviridae; Rhinovirus; Viral Plaque Assay; Virus Replication

1989
Broxaterol: a new beta2-adrenoceptor agonist for the treatment of reversible airways disease. Proceedings of the satellite symposium. Budapest, September 8, 1988.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 2

    Topics: Adrenergic beta-Agonists; Asthma; Bronchitis; Humans; Isoxazoles; Oxazoles

1989
Remarks on broxaterol.
    Respiration; international review of thoracic diseases, 1989, Volume: 55 Suppl 2

    Topics: Adrenergic alpha-Agonists; Asthma; Bronchodilator Agents; Humans; Isoxazoles; Oxazoles

1989
Recovery of the activities of IMP dehydrogenase and GMP synthase after treatment with tiazofurin and acivicin in hepatoma cells in vitro.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Animals; Carbon-Nitrogen Ligases; Cycloheximide; Drug Interactions; IMP Dehydrogenase; Isoxazoles; Ketone Oxidoreductases; Ligases; Liver Neoplasms, Experimental; Oxazoles; Ribavirin; Ribonucleosides; Time Factors; Tumor Cells, Cultured

1989
Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
    Cancer research, 1985, Volume: 45, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Drug Resistance; Genetic Variation; Glutamine; Isoxazoles; Kinetics; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Oxazoles; Phosphoribosyl Pyrophosphate

1985
3-Methylisoxazol-5-one, an artefact from acetoacetic acid formed during urinary organic acid analysis.
    Clinica chimica acta; international journal of clinical chemistry, 1989, Sep-15, Volume: 184, Issue:1

    Topics: Acetoacetates; Carboxylic Acids; Child, Preschool; False Positive Reactions; Humans; Isoxazoles; Lactates; Lactic Acid; Mass Spectrometry; Metabolism, Inborn Errors; Molecular Weight; Oxazoles

1989
Antifungal activity of novel 5-carbonyl derivatives of 3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines.
    Archiv der Pharmazie, 1989, Volume: 322, Issue:9

    Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Oxazoles

1989
Novel 5-substituted 3-(2-naphthalenyl)-3-(1H-imidazol-l-ylmethy)-2-methylisoxazolidine derivatives.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:10

    Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Naphthalenes; Oxazoles

1989
Determination of succinylacetone and succinylacetoacetate in physiological samples as the common product 5(3)-methyl-3(5)-isoxazole propionic acid using an isotope dilution method and mass spectrometry.
    Clinica chimica acta; international journal of clinical chemistry, 1989, Oct-16, Volume: 184, Issue:3

    Topics: Acetoacetates; Gas Chromatography-Mass Spectrometry; Heptanoates; Heptanoic Acids; Humans; Isotopes; Isoxazoles; Mass Spectrometry; Nitrogen Isotopes; Oxazoles; Tyrosine

1989
Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats.
    International journal of immunopharmacology, 1989, Volume: 11, Issue:8

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Autoimmune Diseases; Basement Membrane; Cyclosporins; Isoxazoles; Kidney Tubules; Leflunomide; Nephritis, Interstitial; Oxazoles; Rats; Rats, Inbred BN

1989
Enzymic synthesis of two glucuronides of the hydroxyisoxazole GABA-agonist, THIP, and the in vivo glucuronidation of THIP in rat.
    Xenobiotica; the fate of foreign compounds in biological systems, 1989, Volume: 19, Issue:12

    Topics: Animals; Chromatography, High Pressure Liquid; Glucuronates; Glucuronidase; Hydrolysis; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Oxazoles; Rabbits; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet

1989
Synthesis of some pyrazoline and isoxazolin derivatives as possible fungicides.
    Bollettino chimico farmaceutico, 1989, Volume: 128, Issue:11

    Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Pyrazoles

1989
Studies on antifungal agents. 19. Effect of the C-5-aromatic substitution on the in vitro activity of novel 3,5-substituted isoxazolidines.
    Chemotherapy, 1989, Volume: 35, Issue:1

    Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Chemical Phenomena; Chemistry; Fungi; Isoxazoles; Oxazoles; Trichophyton

1989
Studies on antifungal agents. 20. Effect of the nitrogen substitution on the in vitro activity of novel 3,5-substituted isoxazolidines.
    Chemotherapy, 1989, Volume: 35, Issue:2

    Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Chemical Phenomena; Chemistry; Isoxazoles; Nitrogen; Oxazoles; Trichophyton

1989
Animal behavioral and neurochemical effects of the CNS toxic amino acid antitumor agent, acivicin.
    Research communications in chemical pathology and pharmacology, 1989, Volume: 63, Issue:2

    Topics: Action Potentials; Amino Acids; Animals; Antibiotics, Antineoplastic; Avoidance Learning; Behavior, Animal; Brain Chemistry; Cats; Discrimination, Psychological; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Macaca mulatta; Male; Mice; Neurons; Oxazoles; Rats; Rats, Inbred F344

1989
Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells.
    Biochemical and biophysical research communications, 1989, May-30, Volume: 161, Issue:1

    Topics: Antimetabolites; Cell Line; Cisplatin; Drug Combinations; Growth Inhibitors; Humans; Isoxazoles; Lung Neoplasms; Oxazoles; Thymidine Kinase; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured

1989
Isoxazoles V: chemical stability of diisoxazolylnaphthoquinone in aqueous solution.
    Journal of pharmaceutical sciences, 1989, Volume: 78, Issue:5

    Topics: Catalysis; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Isoxazoles; Kinetics; Oxazoles; Temperature

1989
Inhibition of the mitochondrial phosphate carrier by a reaction with a carboxyl group reagent.
    Biochemical and biophysical research communications, 1989, Jul-14, Volume: 162, Issue:1

    Topics: Animals; Binding, Competitive; Biological Transport; Borohydrides; Carrier Proteins; Cattle; Indicators and Reagents; Isoxazoles; Liposomes; Mitochondria, Heart; Oxazoles; Phosphate-Binding Proteins; Phosphates

1989
Selection of orally active antifungal agents from 3,5-substituted isoxazolidine derivatives based on acute efficacy-safety profiles.
    Antimicrobial agents and chemotherapy, 1989, Volume: 33, Issue:6

    Topics: Administration, Oral; Analgesics; Animals; Anticonvulsants; Antifungal Agents; Female; Isoxazoles; Male; Mice; Microbial Sensitivity Tests; Nervous System Diseases; Oxazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1989
[Effect of bucid on oxidation-reduction processes in the microsomes and mitochondria of the animal liver].
    Gigiena i sanitariia, 1989, Issue:5

    Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Activation; Isoxazoles; Lipid Peroxidation; Male; Microsomes, Liver; Mitochondria, Liver; Oxazoles; Oxidation-Reduction; Rats

1989
Reaction of Woodward's reagent K with D-xylose isomerases. Modification of an active site carboxylate residue.
    The Biochemical journal, 1989, May-15, Volume: 260, Issue:1

    Topics: Aldose-Ketose Isomerases; Binding Sites; Carbohydrate Epimerases; Indicators and Reagents; Isoxazoles; Kinetics; Ligands; Oxazoles

1989
New isoxazole derivatives provided with antihypertensive activity.
    Arzneimittel-Forschung, 1989, Volume: 39, Issue:6

    Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Chemical Phenomena; Chemistry; Clonidine; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxazoles; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Vas Deferens; Yohimbine

1989
Effects of GABA, THIP, and potassium on excitability of myelinated axons of isolated amphibian spinal roots.
    Canadian journal of physiology and pharmacology, 1989, Volume: 67, Issue:6

    Topics: Anesthetics; Animals; Axons; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Myelin Sheath; Oxazoles; Potassium; Rana catesbeiana; Spinal Cord

1989
Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin.
    Blood, 1989, Volume: 74, Issue:5

    Topics: Antibiotics, Antineoplastic; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Isoxazoles; Kinetics; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Leukocytes; Oxazoles; Reference Values; Tumor Cells, Cultured

1989
Inhibition of poliovirus uncoating by disoxaril (WIN 51711).
    Virology, 1987, Volume: 160, Issue:1

    Topics: Antiviral Agents; Capsid; Depression, Chemical; Endocytosis; HeLa Cells; Humans; Isoxazoles; Lysosomes; Oxazoles; Poliovirus; RNA, Viral; Virus Replication

1987
Effect of gamma-aminobutyric acidA receptor agonists and antagonists on the release of enkephalin-containing peptides from dog adrenal gland.
    The Journal of pharmacology and experimental therapeutics, 1987, Volume: 243, Issue:1

    Topics: Adrenal Medulla; Analgesics; Animals; Bicuculline; Catecholamines; Dogs; Electric Stimulation; Enkephalins; Female; Isoxazoles; Oxazoles; Receptors, GABA-A; Splanchnic Nerves

1987
Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:3

    Topics: Antiviral Agents; Computer Simulation; Humans; Isoxazoles; Models, Molecular; Oxazoles; Rhinovirus; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction

1988
Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus.
    Neuroscience letters, 1988, May-03, Volume: 87, Issue:3

    Topics: Acetylcholine; Animals; Brain Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamus

1988
GABA-related drugs modulate the behavioral effects of lorazepam.
    Psychopharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Behavior, Animal; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Lorazepam; Male; Oxazoles; Receptors, GABA-A; Saimiri

1988
Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1987, Volume: 5, Issue:3

    Topics: Animals; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Organelles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors

1987
GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 1988, Volume: 6, Issue:2

    Topics: Animals; Cells, Cultured; Cerebellar Cortex; Isoxazoles; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A

1988
[3H]zonisamide binding in rat brain.
    The Japanese journal of psychiatry and neurology, 1988, Volume: 42, Issue:3

    Topics: Animals; Anticonvulsants; Brain; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes; Zonisamide

1988
Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.
    Drug design and delivery, 1987, Volume: 1, Issue:4

    Topics: Animals; Bicuculline; Brain Chemistry; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Isoxazoles; Oxazoles; Piperidines; Pyrrolidines; Rats; Receptors, GABA-A; Synaptic Membranes

1987
Use of acivicin in the determination of rate constants for turnover of rat renal gamma-glutamyltranspeptidase.
    The Journal of biological chemistry, 1985, Mar-25, Volume: 260, Issue:6

    Topics: Animals; gamma-Glutamyltransferase; Goats; Immunoglobulin G; Isoxazoles; Kidney; Kinetics; Mathematics; Oxazoles; Rats; Rats, Inbred Strains

1985
Effect of inhibition of gamma-glutamyltranspeptidase by AT-125 (acivicin) on glutathione and cysteine levels in rat brain and plasma.
    Investigational new drugs, 1985, Volume: 3, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Brain; Cysteine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains

1985
Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:6

    Topics: Animals; Antipsychotic Agents; Corpus Striatum; In Vitro Techniques; Isoxazoles; Male; Mice; Motor Activity; Oxazoles; Piperidines; Spiperone; Structure-Activity Relationship

1985
Excitatory amino acids: studies on the biochemical and chemical stability of ibotenic acid and related compounds.
    Journal of neurochemistry, 1985, Volume: 45, Issue:3

    Topics: Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Decarboxylation; Glutamates; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Ibotenic Acid; Isoxazoles; Liver; Mice; Muscimol; Oxazoles; Pregnancy Proteins

1985
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:3

    Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Catalepsy; Cerebral Cortex; Corpus Striatum; Isoxazoles; Male; Models, Molecular; Norepinephrine; Oxazoles; Physostigmine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sleep; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles

1986
New isoxazole derivatives with a potent and selective beta 2-adrenergic activity.
    Il Farmaco; edizione scientifica, 1986, Volume: 41, Issue:6

    Topics: Adrenergic beta-Antagonists; Animals; Bronchodilator Agents; Chemical Phenomena; Chemistry; Dihydroalprenolol; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Muscle, Smooth; Oxazoles; Rats; Serotonin; Trachea

1986
Effect of acivicin on glutamine transport by rat renal brush border membrane vesicles.
    The Journal of laboratory and clinical medicine, 1986, Volume: 108, Issue:4

    Topics: Amino Acids; Animals; Biological Transport; gamma-Glutamyltransferase; Glucose; Glutamine; In Vitro Techniques; Isoxazoles; Kidney Cortex; Microvilli; Oxazoles; Rats

1986
Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism.
    The American journal of physiology, 1987, Volume: 252, Issue:5 Pt 2

    Topics: Animals; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Kidney Tubules; Male; Methionine Sulfoximine; Oxazoles; Rats

1987
Embryotoxicity elicited by inhibition of gamma-glutamyltransferase by Acivicin and transferase antibodies in cultured rat embryos.
    Toxicology and applied pharmacology, 1987, Jun-15, Volume: 89, Issue:1

    Topics: Animals; Embryo, Mammalian; gamma-Glutamyltransferase; Immunoglobulin G; Isoxazoles; Organ Culture Techniques; Oxazoles; Proteins; Rats; Rats, Inbred Strains

1987
[Comparison of the effectiveness and tolerance of a new beta-2 stimulant (broxaterol) vs. salbutamol in patients with chronic obstructive bronchopneumopathy].
    La Clinica terapeutica, 1987, Apr-15, Volume: 121, Issue:1

    Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Female; Forced Expiratory Volume; Humans; Isoxazoles; Lung Diseases, Obstructive; Male; Middle Aged; Oxazoles; Vital Capacity

1987
Effects of AT-125 on the nephrotoxicity of hexachloro-1,3-butadiene in rats.
    Toxicology and applied pharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Butadienes; gamma-Glutamyltransferase; Glycosuria; Isoxazoles; Kidney Diseases; Kidney Function Tests; Male; Oxazoles; Rats; Rats, Inbred Strains; Urine

1988
Acivicin inhibits Crithidia fasciculata growth in a serum-free medium and inactivates carbamoyl-phosphate synthetase II in vivo.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1988, Volume: 90, Issue:2

    Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Count; Cells, Cultured; Crithidia; Culture Media; Cytidine; Guanosine; Isoxazoles; Oxazoles

1988
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
    Journal of medicinal chemistry, 1989, Volume: 32, Issue:2

    Topics: Antiviral Agents; Coronaviridae; Humans; Isoxazoles; Oxazoles; Structure-Activity Relationship

1989
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
    Experimental neurology, 1989, Volume: 104, Issue:1

    Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures

1989
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
    General pharmacology, 1985, Volume: 16, Issue:5

    Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Seizures

1985
A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen.
    Neuropharmacology, 1985, Volume: 24, Issue:3

    Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Oxazoles; Postural Balance; Receptors, GABA-A

1985
Isoxazoles with antipicornavirus activity.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:6

    Topics: Animals; Antiviral Agents; Isoxazoles; Mice; Mice, Inbred ICR; Oxazoles; Picornaviridae; Picornaviridae Infections; Structure-Activity Relationship

1985
Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analogue of the GABA agonist THIP.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:8

    Topics: Animals; Anticonvulsants; Cerebellum; Electrophysiology; Female; Isoxazoles; Male; Mice; Muscimol; Oxazoles; Rats; Receptors, GABA-A

1985
In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug.
    Antimicrobial agents and chemotherapy, 1985, Volume: 27, Issue:6

    Topics: Antiviral Agents; Culture Media; Enterovirus; HeLa Cells; Humans; Isoxazoles; Oxazoles; Picornaviridae; Rhinovirus; Time Factors; Viral Plaque Assay; Virus Replication

1985
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:12

    Topics: Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Isoxazoles; Mice; Oxazoles; Picornaviridae Infections; Poliovirus; Rhinovirus; Structure-Activity Relationship; Time Factors; Virus Replication

1985
Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA agonist or antagonist.
    Physiology & behavior, 1985, Volume: 35, Issue:3

    Topics: Aggression; Animals; Bicuculline; Brain; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission

1985
Autoradiographic localization of binding sites for the gamma-aminobutyric acid analogues 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP)isoguvacine and baclofen on cultured neurons of rat cerebellum and spinal cord.
    Neuroscience letters, 1985, Oct-24, Volume: 61, Issue:1-2

    Topics: Animals; Animals, Newborn; Autoradiography; Baclofen; Binding Sites; Cells, Cultured; Cerebellum; Fetus; Isonicotinic Acids; Isoxazoles; Oxazoles; Rats; Receptors, GABA-A; Spinal Cord

1985
Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions.
    Journal of medicinal chemistry, 1986, Volume: 29, Issue:2

    Topics: Animals; Glycine; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Molecular Conformation; Oxazoles; Rats; Receptors, GABA-A; Spectrophotometry, Infrared; Structure-Activity Relationship

1986
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
    The Journal of pharmacology and experimental therapeutics, 1986, Volume: 237, Issue:2

    Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Nervous System; Oxazoles; Receptors, GABA-A; Seizures

1986
Quantitative determination of acivicin in bulk drug and pharmaceutical formulations by ion-pair high-performance liquid chromatography.
    Journal of chromatography, 1986, Apr-23, Volume: 357, Issue:1

    Topics: Antineoplastic Agents; Benzyl Alcohol; Benzyl Alcohols; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Isoxazoles; Oxazoles; Perchlorates; Powders; Solutions

1986
GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors.
    Neurochemical research, 1986, Volume: 11, Issue:4

    Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Intracellular Membranes; Isoxazoles; Kinetics; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A

1986
Glycine antagonists structurally related to 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin-3-ol inhibit binding of [3H]strychnine to rat brain membranes.
    Journal of neurochemistry, 1986, Volume: 47, Issue:3

    Topics: Animals; Anions; Binding, Competitive; Cell Membrane; Chlorides; Choline; GABA Antagonists; Glycine; Isoxazoles; Male; Medulla Oblongata; Oxazoles; Pons; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Sodium Chloride; Strychnine

1986
Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug.
    Antimicrobial agents and chemotherapy, 1986, Volume: 30, Issue:1

    Topics: Antiviral Agents; Cells, Cultured; Centrifugation, Density Gradient; Hot Temperature; Humans; Isoxazoles; Oxazoles; Poliovirus; Rhinovirus; Sucrose; Time Factors; Uridine; Virus Replication

1986
Phase II study of acivicin in non-small cell lung cancer: a National Cancer Institute of Canada Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:11

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Carcinoma, Non-Small-Cell Lung; Cognition Disorders; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Male; Middle Aged; Oxazoles

1986
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
    Journal of medicinal chemistry, 1987, Volume: 30, Issue:2

    Topics: Antiviral Agents; Humans; Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Rhinovirus; Species Specificity; Structure-Activity Relationship

1987
[Changes in the ligand affinity of benzodiazepine receptors in the presence of 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP)].
    Biulleten' eksperimental'noi biologii i meditsiny, 1987, Volume: 103, Issue:2

    Topics: Animals; Brain; Depression, Chemical; Dose-Response Relationship, Drug; Flunitrazepam; In Vitro Techniques; Isoxazoles; Ligands; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
Effect of THIP and SL 76002, two clinically experimented GABA-mimetic compounds, on anterior pituitary GABA receptors and prolactin secretion in the rat.
    Life sciences, 1987, Mar-02, Volume: 40, Issue:9

    Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Female; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Male; Muscimol; Ovariectomy; Oxazoles; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A

1987
Hypnotic action of pentobarbital in mice: a possible mechanism.
    Experimental neurology, 1987, Volume: 97, Issue:1

    Topics: Animals; Baclofen; Bicuculline; Isoxazoles; Male; Mice; Oxazoles; Pentobarbital; Receptors, GABA-A; Reflex; Sleep

1987
The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission.
    Neuropharmacology, 1987, Volume: 26, Issue:5

    Topics: Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; GABA Antagonists; Isoxazoles; Male; Mice; Oxazoles; Pain; Physostigmine; Synaptic Transmission

1987
Respiratory depressant effects of GABA alpha- and beta-receptor agonists in the cat.
    Journal of applied physiology (Bethesda, Md. : 1985), 1987, Volume: 62, Issue:6

    Topics: Animals; Baclofen; Bicuculline; Cats; Female; Heart; Injections, Intravenous; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, GABA-A; Respiration

1987
Studies on antifungal agents. 17. Effects of the C-5-substitution on the in vitro activity of novel 3,5-substituted isoxazolidines.
    Chemotherapy, 1988, Volume: 34, Issue:5

    Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Trichophyton

1988
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
    Pharmacology, biochemistry, and behavior, 1986, Volume: 24, Issue:4

    Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid

1986
Acivicin reduces tumor growth during total parenteral nutrition (TPN).
    Surgery, 1987, Volume: 102, Issue:2

    Topics: Animals; Antimetabolites; Body Weight; Glutamine; Isoxazoles; Male; Neoplasm Transplantation; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Soft Tissue Neoplasms

1987
Progressive myoclonus epilepsy treated with zonisamide.
    Neurology, 1988, Volume: 38, Issue:6

    Topics: Adult; Epilepsies, Myoclonic; Humans; Isoxazoles; Male; Oxazoles; Zonisamide

1988
6-Sulfanilamidoindazole arthritis in rats: influence of the new anti-inflammatory agent CGP 28237 and of the immunomodulating compound HWA 486 on degree of arthritis and on acute phase reaction.
    Die Pharmazie, 1988, Volume: 43, Issue:1

    Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Indans; Indenes; Inflammation; Isoxazoles; Leflunomide; Oxazoles; Rats; Sulfanilamides

1988
Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition.
    Annals of surgery, 1988, Volume: 208, Issue:4

    Topics: Animals; Antimetabolites; Body Weight; Eating; Energy Intake; Insulin; Isoxazoles; Male; Muscle Proteins; Muscles; Organ Size; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental

1988
Synthesis and biological activity of the metabolites of [3,4-bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid.
    Chemical & pharmaceutical bulletin, 1988, Volume: 36, Issue:8

    Topics: Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Isoxazoles; Oxazoles

1988
The antiepileptic effect of zonisamide on patients with refractory seizures and its side effect.
    The Japanese journal of psychiatry and neurology, 1988, Volume: 42, Issue:3

    Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Evoked Potentials; Female; Humans; Isoxazoles; Male; Oxazoles; Zonisamide

1988
The use of carotenoids and oxonol VI as probes for membrane potential in proteoliposomes.
    FEBS letters, 1985, May-06, Volume: 184, Issue:1

    Topics: Adenosine Triphosphatases; Carotenoids; Cyanobacteria; Isoxazoles; Membrane Potentials; Oxazoles; Potassium; Proteolipids

1985
Inducing anesthesia with a GABA analog, THIP.
    Anesthesiology, 1985, Volume: 63, Issue:2

    Topics: Analgesics; Anesthesia, Intravenous; Anesthetics; Animals; Benzodiazepines; gamma-Aminobutyric Acid; Isoxazoles; Ketamine; Male; Mice; Midazolam; Oxazoles; Rats; Rats, Inbred Strains; Sodium Oxybate; Time Factors

1985
Phase I-II trial of acivicin in adult acute leukemia.
    Investigational new drugs, 1988, Volume: 6, Issue:1

    Topics: Aged; Antibiotics, Antineoplastic; Drug Evaluation; Humans; Isoxazoles; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Middle Aged; Oxazoles

1988
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
    Investigational new drugs, 1988, Volume: 6, Issue:2

    Topics: Adult; Aged; Alanine; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Administration Schedule; Drug Evaluation; Female; Humans; Isoxazoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Oxazoles; Thiadiazoles; Vinblastine

1988
Studies on antifungal agents. 23. Novel substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)- 2-alkylisoxazolidine derivatives.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:10

    Topics: Animals; Antifungal Agents; Candidiasis; Imidazoles; Isoxazoles; Ketoconazole; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Mitosporic Fungi; Oxazoles; Rats; Structure-Activity Relationship

1988
Impermeant potential-sensitive oxonol dyes: I. Evidence for an "on-off" mechanism.
    The Journal of membrane biology, 1988, Volume: 103, Issue:3

    Topics: Benzenesulfonates; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Cholesterol; Erythrocytes; Fluorescent Dyes; Humans; Isoxazoles; Lipid Bilayers; Membrane Potentials; Oxazoles; Spectrophotometry, Atomic

1988
Conversion of Woodward's Reagent K in an aqueous medium: mathematical analysis applied to enzyme modification.
    Analytical biochemistry, 1988, Volume: 172, Issue:1

    Topics: Indicators and Reagents; Isoxazoles; Kinetics; Mathematics; Models, Chemical; NAD; Oxazoles; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Transketolase

1988
The effects of acivicin on glutamine transport by renal basolateral membrane vesicles.
    Contributions to nephrology, 1988, Volume: 63

    Topics: Alanine; Animals; Biological Transport; Cell Membrane; Glutamine; Isoxazoles; Kidney; Oxazoles; Rats

1988
Synthesis and antifungal activity of novel isoxazolidine compounds.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Animals; Antifungal Agents; Candidiasis, Vulvovaginal; Drug Design; Female; Fungi; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Rats; Structure-Activity Relationship

1988
Substituted 5-phenoxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidines. Antifungal activity and structure-activity relationship studies.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Structure-Activity Relationship

1988
In vitro antifungal activity of novel substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine derivatives.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
cis-3-(substituted phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-([(substituted phenyl)thio(or amino)]methyl)isoxazolidines. In vitro antifungal activity and structure-activity relationships.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
3-(substituted phenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5- [(substituted phenoxy)methyl]-isoxazolidine derivatives. Structure-activity relationships.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
cis-5-alkoxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
In vitro antifungal activity of novel substituted 3,5-diphenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2- methylisoxazolidine derivatives.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship; Triazoles

1988
In vitro antifungal activity and structure-activity relationship studies of novel cis-5-acyloxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
cis-5-alkyl(or alkenyl)-3-phenyl-3-(1H-imidazole-1-ylmethyl)-2- methylisoxazolidine derivatives. In vitro antifungal activity and structure-activity relationships.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
Novel 5-phenyl(or phenoxyalkyl)-3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidines. In vitro antifungal activity.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
In vitro activity of novel 5-(phenyl or phenoxyalkyl)-3-(2-thienyl)-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidines.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
In vitro activity of novel 5-carbonyl derivatives of 3-phenyl-3-(1H-imidazol-1-ylmethyl)- 2-methyl-isoxazolidines.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
In vitro activity of novel cis-5-substituted-3-(2-naphthalenyl)-3-(1H-imidazol-1-ylmethyl)- 2-methylisoxazolidine derivatives.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship

1988
[Studies on the metabolisms of azolecarboxylic acids closely related to the fusaric acid(5-butylpyridine-2-carboxylic acid)].
    Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 1988, Volume: 108, Issue:4

    Topics: Administration, Oral; Animals; Azoles; Carboxylic Acids; Chemical Phenomena; Chemistry; Fusaric Acid; Gas Chromatography-Mass Spectrometry; Isoxazoles; Male; Oxazoles; Picolinic Acids; Pyrazoles; Rats; Rats, Inbred Strains

1988
Amplification by glycine of the effect of the GABA transport inhibitor THPO on synaptosomal GABA level.
    Neurochemical research, 1988, Volume: 13, Issue:10

    Topics: Amino Acids; Animals; Brain; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Oxazoles; Synaptosomes

1988
[Thiophene as a structural element in physiologically active substances. 17. Thienoisoxazoles through nucleophile substitution].
    Archiv der Pharmazie, 1988, Volume: 321, Issue:7

    Topics: Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Thiophenes

1988
Chronic toxicity of the anticonvulsant zonisamide in beagle dogs.
    Fundamental and applied toxicology : official journal of the Society of Toxicology, 1988, Volume: 11, Issue:2

    Topics: Administration, Oral; Animals; Anticonvulsants; Body Weight; Dogs; Eating; Electrocardiography; Isoxazoles; Liver; Oxazoles; Serum Albumin; Sex Factors; Time Factors; Zonisamide

1988
Impermeant potential-sensitive oxonol dyes: II. The dependence of the absorption signal on the length of alkyl substituents attached to the dye.
    The Journal of membrane biology, 1988, Volume: 105, Issue:1

    Topics: Adsorption; Cholesterol; Hydrocarbons; Isoxazoles; Lipid Bilayers; Oxazoles

1988
Impermeant potential-sensitive oxonol dyes: III. The dependence of the absorption signal on membrane potential.
    The Journal of membrane biology, 1988, Volume: 105, Issue:1

    Topics: Adsorption; Cholesterol; Isoxazoles; Lipid Bilayers; Mathematics; Membrane Potentials; Oxazoles; Thermodynamics

1988
5-( [aryl or aryloxy (or thio)]methyl)-3-(1H-imidazol-1-ylmethyl)-3- (2-thienyl)-2-methylisoxazolidine derivatives as novel antifungal agents.
    Journal of pharmaceutical sciences, 1988, Volume: 77, Issue:12

    Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Conformation; Oxazoles; Thiophenes

1988
The structure of (1,2-benzisoxazol-3-yl)methanesulfonamide: a novel antiepileptic drug.
    Acta crystallographica. Section C, Crystal structure communications, 1988, Nov-15, Volume: 44 ( Pt 11)

    Topics: Anticonvulsants; Hydrogen Bonding; Isoxazoles; Models, Molecular; Molecular Conformation; Oxazoles; X-Ray Diffraction; Zonisamide

1988
Comparisons of ketoconazole, PR 969-566, PR 967-234, and PR 967-248 as antifungals in vitro and in the rat model of candidal vaginitis based on efficacy/safety profiles.
    Annals of the New York Academy of Sciences, 1988, Volume: 544

    Topics: Animals; Antifungal Agents; Candida; Candidiasis, Vulvovaginal; Disease Models, Animal; Female; Fungi; Isoxazoles; Ketoconazole; Microbial Sensitivity Tests; Oxazoles; Rats

1988
Reduction of tumor growth following treatment with a glutamine antimetabolite.
    Life sciences, 1988, Volume: 42, Issue:1

    Topics: Amino Acids; Animals; Antibiotics, Antineoplastic; Antimetabolites; Body Weight; Energy Intake; Glutamine; Isoxazoles; Male; Methylcholanthrene; Oxazoles; Rats; Rats, Inbred F344; Sarcoma, Experimental

1988
Cardioactivity and solid-state structure of two 4-isoxazolyldihydropyridines related to the 4-aryldihydropyridine calcium-channel blockers.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:2

    Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Isoxazoles; Oxazoles; Structure-Activity Relationship; X-Ray Diffraction

1988
Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin.
    Biochemical pharmacology, 1988, Mar-01, Volume: 37, Issue:5

    Topics: Animals; Aspartate Carbamoyltransferase; Bone Marrow; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Deoxycytidine Kinase; Isoxazoles; Ligases; Orotidine-5'-Phosphate Decarboxylase; Oxazoles; Rats; Ribavirin; Ribonucleoside Diphosphate Reductase; Ribonucleosides; Thymidine Monophosphate; Thymidylate Synthase

1988
Functional responses to baclofen and 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-ol (THIP) in rats repeatedly treated with desipramine.
    Pharmacology, biochemistry, and behavior, 1988, Volume: 29, Issue:1

    Topics: Analgesics; Animals; Baclofen; Behavior, Animal; Body Temperature; Desipramine; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains

1988
Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and acivicin in sensitive and resistant tumor cell lines.
    International journal of cancer, 1988, May-15, Volume: 41, Issue:5

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Azo Compounds; Biological Transport; Colonic Neoplasms; Diazooxonorleucine; Drug Resistance; Glutamine; Humans; Isoxazoles; Kinetics; Leukemia P388; Lung Neoplasms; Mice; Neoplasms, Experimental; Oxazoles; Tumor Cells, Cultured

1988
The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance.
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 1988, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Behavior; Carotid Arteries; Cerebrovascular Circulation; Dominance, Cerebral; Electroencephalography; gamma-Aminobutyric Acid; Humans; Injections, Intra-Arterial; Isoxazoles; Middle Aged; Neural Inhibition; Oxazoles; Synapses

1988
Gamma-aminobutyric acid agonist-induced alterations in the ultrastructure of cultured cerebellar granule cells is restricted to early development.
    Journal of neurochemistry, 1988, Volume: 51, Issue:1

    Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasm; Endoplasmic Reticulum; gamma-Aminobutyric Acid; Golgi Apparatus; Isoxazoles; Microscopy, Electron; Oxazoles; Rats; Rats, Inbred Strains

1988
Synthesis of the tumorigenic 3,4-dihydrodiol metabolites of dibenz[a,j]anthracene and 7,14-dimethyldibenz[a,j]anthracene.
    Journal of medicinal chemistry, 1988, Volume: 31, Issue:7

    Topics: Animals; Benz(a)Anthracenes; Chemical Phenomena; Chemistry; Female; Isoxazoles; Mice; Oxazoles; Papilloma; Skin Neoplasms; Structure-Activity Relationship

1988
[5-(3-aminopropyl)-isoxazoles: synthesis and antibacterial activity of various derivatives].
    Archiv der Pharmazie, 1988, Volume: 321, Issue:3

    Topics: Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry; Isoxazoles; Microbial Sensitivity Tests; Oxazoles

1988
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
    Brain research, 1988, May-31, Volume: 450, Issue:1-2

    Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds

1988
Pharmacokinetics and metabolism of alpha-[(dimethylamino)methyl]-2- (3-ethyl-5-methyl-4-isoxazolyl)-1H-indole-3-methanol, a hypoglycemic agent, in man.
    Xenobiotica; the fate of foreign compounds in biological systems, 1987, Volume: 17, Issue:10

    Topics: Adolescent; Adult; Biotransformation; Humans; Hypoglycemic Agents; Isoxazoles; Male; Mass Spectrometry; Oxazoles

1987
Inhibition of progesterone secretion and decrease of ovarian blood flow by isoxazole in pregnant rats.
    Acta physiologica Hungarica, 1987, Volume: 70, Issue:1

    Topics: Animals; Corticosterone; Estradiol; Female; Isoxazoles; Ovary; Oxazoles; Pregnancy; Pregnancy, Animal; Progesterone; Rats; Regional Blood Flow

1987
General pharmacology of the novel antiepileptic compound zonisamide. 1st communication: effects on central nervous system.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:10

    Topics: Animals; Anticonvulsants; Brain; Cats; Cerebrovascular Circulation; Cognition; Electroencephalography; Female; Hydrogen-Ion Concentration; Isoxazoles; Male; Mice; Mice, Inbred Strains; Oxazoles; Rats; Rats, Inbred Strains; Reflex; Species Specificity; Zonisamide

1987
General pharmacology of the novel antiepileptic compound zonisamide. 2nd communication: effects on cardiovascular, visceral, renal and blood functions.
    Arzneimittel-Forschung, 1987, Volume: 37, Issue:10

    Topics: Animals; Anticonvulsants; Autonomic Nervous System; Blood Coagulation; Cats; Digestive System; Dogs; Electrocardiography; Female; Guinea Pigs; Hemodynamics; Hemolysis; In Vitro Techniques; Isoxazoles; Kidney; Male; Mice; Oxazoles; Rats; Zonisamide

1987
GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat.
    Brain research, 1987, Dec-15, Volume: 436, Issue:2

    Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Periaqueductal Gray; Picrotoxin; Raphe Nuclei; Rats; Rats, Inbred Strains

1987
Isoxazole derivatives as centrally acting muscle relaxants. III. Synthesis and activity of conformationally restricted analogs.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:9

    Topics: Animals; Avoidance Learning; Chemical Phenomena; Chemistry; Isoxazoles; Mice; Molecular Conformation; Muscle Relaxants, Central; Oxazoles; Rats

1987
Phase II study of acivicin as a 72-hr continuous infusion in patients with untreated colorectal cancer. A National Cancer Institute of Canada Clinical Trials Group Study.
    Investigational new drugs, 1987, Volume: 5, Issue:4

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Colonic Neoplasms; Drug Evaluation; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Oxazoles; Rectal Neoplasms

1987
Syntheses of 3,6-substituted-4-(3',4',5'-substituted-1'-pyrazolyl)-isoxazo lo[5,4-d] pyrimidines as potential antiinflammatory agents.
    Archiv der Pharmazie, 1987, Volume: 320, Issue:11

    Topics: Animals; Anti-Inflammatory Agents; Bacteria; Chemical Phenomena; Chemistry; Fungi; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pyrazoles; Pyrimidines; Rats

1987
Substituted spiro[isoxazolidine-3,2'-tricyclo[3.3.1.1(3,7)]decane] derivatives.
    Journal of pharmaceutical sciences, 1987, Volume: 76, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry; Edema; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Spiro Compounds

1987
Membrane potential and cation content of osteoblast-like cells (UMR 106) assessed by fluorescent dyes.
    Journal of cellular physiology, 1987, Volume: 131, Issue:3

    Topics: Animals; Barbiturates; Cations; Cell Line; Electrophysiology; Fluorescent Dyes; Hydrogen-Ion Concentration; Intracellular Fluid; Isoxazoles; Membrane Potentials; Osteoblasts; Osteosarcoma; Oxazoles; Rats

1987
Immunopharmacological profile of HWA 486, a novel isoxazol derivative--II. In vivo immunomodulating effects differ from those of cyclophosphamide, prednisolone, or cyclosporin A.
    International journal of immunopharmacology, 1986, Volume: 8, Issue:2

    Topics: Animals; Antibody Formation; Antibody-Producing Cells; B-Lymphocytes; Cyclophosphamide; Cyclosporins; Female; Immune System; Isoxazoles; Leflunomide; Luminescent Measurements; Lymphocyte Activation; Mice; Mitogens; Oxazoles; Prednisolone; T-Lymphocytes

1986
Disease modifying activity of HWA 486 in rat adjuvant-induced arthritis.
    Agents and actions, 1987, Volume: 21, Issue:3-4

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Cyclosporins; Hypersensitivity, Delayed; In Vitro Techniques; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Oxazoles; Rats; Rats, Inbred Lew

1987
High-performance of liquid chromatographic determination of [3,4-di-(4-methoxyphenyl)-5-isoxazolyl]acetic acid and its metabolites in human plasma and urine.
    Journal of chromatography, 1987, Nov-27, Volume: 422

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoxazoles; Oxazoles; Spectrophotometry, Ultraviolet

1987
Yeast enolase carboxyl modification using Woodward's reagent K.
    Biochemistry and cell biology = Biochimie et biologie cellulaire, 1986, Volume: 64, Issue:10

    Topics: Amino Acids; Isoxazoles; Kinetics; Oxazoles; Peptide Fragments; Phosphopyruvate Hydratase; Protein Binding; Saccharomyces cerevisiae

1986
Simultaneous determination of Zonisamide and nine other anti-epileptic drugs and metabolites in serum. A comparison of microbore and conventional high-performance liquid chromatography.
    Journal of chromatography, 1987, Jan-09, Volume: 385

    Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoxazoles; Oxazoles; Zonisamide

1987
Platinum(IV) chloride complexes with heterocyclic ligands.
    Journal of inorganic biochemistry, 1987, Volume: 29, Issue:2

    Topics: Animals; Antineoplastic Agents; Ethylenediamines; Imidazoles; Indicators and Reagents; Isoxazoles; Leukemia L1210; Male; Mice; Organoplatinum Compounds; Oxazoles; Spectrophotometry; Structure-Activity Relationship

1987
Phase II trial of acivicin in malignant mesothelioma.
    Cancer treatment reports, 1987, Volume: 71, Issue:5

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Isoxazoles; Male; Mesothelioma; Middle Aged; Oxazoles; Peritoneal Neoplasms; Pleural Neoplasms

1987
Inactivation of Crithidia fasciculata carbamoyl phosphate synthetase II by the antitumor drug acivicin.
    Molecular and biochemical parasitology, 1987, Volume: 23, Issue:2

    Topics: Ammonia; Animals; Antineoplastic Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Crithidia; Enzyme Activation; Enzyme Inhibitors; Isoxazoles; Ligases; Oxazoles; Stimulation, Chemical

1987
5-Aryl-3-(2-arylvinyl)-2-methylisoxazolium tetrafluoborates as selective antibacterial compounds.
    Bollettino chimico farmaceutico, 1986, Volume: 125, Issue:11

    Topics: Anti-Bacterial Agents; Bacteria; Isoxazoles; Microbial Sensitivity Tests; Onium Compounds; Oxazoles; Vinyl Compounds

1986
[Synthesis and antimicrobial activity of 3-nitroisoxazole derivatives].
    Il Farmaco; edizione scientifica, 1987, Volume: 42, Issue:4

    Topics: Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry; Isoxazoles; Microbial Sensitivity Tests; Nitro Compounds; Oxazoles

1987
Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines.
    British journal of cancer, 1987, Volume: 55, Issue:6

    Topics: Antimetabolites; Azo Compounds; Cell Cycle; Cell Line; Colonic Neoplasms; Diazooxonorleucine; Drug Evaluation, Preclinical; Glutaminase; Glutamine; Humans; Isoxazoles; Lung Neoplasms; Neoplasms, Experimental; Oxazoles

1987
Increasing anticonvulsant effect of AD-810 (zonisamide) in aging BDF1 mice.
    Life sciences, 1987, Sep-14, Volume: 41, Issue:11

    Topics: Aging; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Isoxazoles; Mice; Oxazoles; Zonisamide

1987
Bicuculline-sensitive and insensitive effects of THIP on the binding of [3H]flunitrazepam.
    Neuropharmacology, 1987, Volume: 26, Issue:7A

    Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Osmolar Concentration; Oxazoles; Rats; Rats, Inbred Strains; Sodium Chloride; Tritium

1987
Intrathecal administration of pentobarbital and THIP: evidence for descending excitatory and inhibitory modulation of a spinal reflex.
    Proceedings of the Western Pharmacology Society, 1987, Volume: 30

    Topics: Analgesics; Animals; Efferent Pathways; Injections, Spinal; Isoxazoles; Male; Neural Inhibition; Oxazoles; Pentobarbital; Rats; Rats, Inbred Strains; Reflex; Spinal Cord

1987
Disposition of alpha-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl)- 1H-indole-3-methanol (59-801), a hypoglycaemic agent in rats, dogs and monkeys.
    Xenobiotica; the fate of foreign compounds in biological systems, 1987, Volume: 17, Issue:6

    Topics: Animals; Dogs; Feces; Female; Hypoglycemic Agents; Isoxazoles; Kinetics; Macaca fascicularis; Male; Oxazoles; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Tissue Distribution

1987
Synthesis and spasmolytic activity of aminoalkyl 2-substituted-2-(1,2-benzisoxazol-3-yl)acetates.
    Chemical & pharmaceutical bulletin, 1987, Volume: 35, Issue:5

    Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Isoxazoles; Male; Muscle Contraction; Oxazoles; Parasympatholytics

1987
Effect of repeated treatment with a gamma-aminobutyric acid receptor agonist on postnatal neural development in rats.
    Journal of neurochemistry, 1987, Volume: 49, Issue:5

    Topics: Animals; Antigens, Surface; Brain; Cell Adhesion; Cell Adhesion Molecules; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Isoxazoles; Nerve Tissue Proteins; Neurons; Organ Size; Oxazoles; Rats; Rats, Inbred Strains

1987
[Thiophene as a structural element of physiologically active compounds. 16. Thienoisoxazoles by substitution at the oxime nitrogen].
    Archiv der Pharmazie, 1987, Volume: 320, Issue:9

    Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Isoxazoles; Mice; Oxazoles; Rats; Thiophenes

1987
Synthesis and antibacterial properties of 7-[2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetamido]cep halospora nic acid derivatives.
    The Journal of antibiotics, 1987, Volume: 40, Issue:11

    Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Biological Availability; Cephalosporins; Isomerism; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Rats; Structure-Activity Relationship

1987
Effect of GABAergic drugs in the behavioral 'despair' test in rats.
    European journal of pharmacology, 1986, Feb-18, Volume: 121, Issue:2

    Topics: Acetates; Aminooxyacetic Acid; Animals; Baclofen; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Muscimol; Oxazoles; Picrotoxin; Rats

1986
Phase II trial of acivicin in patients with advanced epithelial ovarian carcinoma. A Gynecologic Oncology Group Study.
    Investigational new drugs, 1986, Volume: 4, Issue:1

    Topics: Adult; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Nervous System Diseases; Ovarian Neoplasms; Oxazoles

1986
[Anticoagulant isoxazolidine-3,5-diones].
    Archiv der Pharmazie, 1986, Volume: 319, Issue:2

    Topics: Animals; Anticoagulants; Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Prothrombin Time; Rats

1986
Acivicin (AT 125, U 42126): isolation and structure of an alkali-induced contaminant.
    The Journal of antibiotics, 1986, Volume: 39, Issue:4

    Topics: Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Drug Contamination; Hydrogen-Ion Concentration; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles

1986
Isoxazole derivatives as centrally acting muscle relaxants. I. Synthesis and activity of 5-(3-aminopropyl)amino-3-phenylisoxazole derivatives.
    Chemical & pharmaceutical bulletin, 1986, Volume: 34, Issue:4

    Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Isoxazoles; Male; Mice; Mice, Inbred ICR; Muscle Relaxants, Central; Oxazoles; Rats; Rats, Inbred Strains

1986
Isoxazole derivatives as centrally acting muscle relaxants. II. Synthesis and structure-activity relationship of 3-amino-N-(3-phenyl-5-isoxazolyl)propanamides.
    Chemical & pharmaceutical bulletin, 1986, Volume: 34, Issue:4

    Topics: Animals; Chemical Phenomena; Chemistry; Isoxazoles; Male; Mice; Muscle Relaxants, Central; Oxazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1986
Phase II trial of acivicin in patients with advanced colorectal carcinoma.
    American journal of clinical oncology, 1986, Volume: 9, Issue:3

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Leukopenia; Male; Middle Aged; Nausea; Neoplasm Metastasis; Oxazoles; Rectal Neoplasms; Vomiting

1986
Oral efficacy of WIN 51711 in mice infected with human poliovirus.
    Antimicrobial agents and chemotherapy, 1986, Volume: 29, Issue:1

    Topics: Animals; Antiviral Agents; Brain; Female; Humans; Isoxazoles; Mice; Mice, Inbred ICR; Oxazoles; Poliomyelitis; Spinal Cord; Time Factors

1986
Tissue distribution, metabolism, anticonvulsant efficacy and effect on brain amino acid levels of the glia-selective gamma-aminobutyric acid transport inhibitor 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol in mice and chicks.
    Journal of neurochemistry, 1986, Volume: 47, Issue:3

    Topics: Amino Acids; Animals; Anticonvulsants; Biological Transport; Brain; Chickens; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Liver; Male; Mice; Oxazoles; Tissue Distribution

1986
Depression of drug-induced tremor by a new isoxazol derivative in mice.
    Japanese journal of pharmacology, 1986, Volume: 41, Issue:1

    Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Harmaline; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxazoles; Tremor; Tremorine

1986
Use of WIN 51711 to prevent echovirus type 9-induced paralysis in suckling mice.
    The Journal of infectious diseases, 1986, Volume: 154, Issue:4

    Topics: Administration, Oral; Animals; Animals, Suckling; Antiviral Agents; Echovirus 9; Echovirus Infections; Injections, Intraperitoneal; Isoxazoles; Mice; Oxazoles; Paralysis; Tissue Distribution

1986
Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy.
    Therapeutic drug monitoring, 1986, Volume: 8, Issue:3

    Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Carbamazepine; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Humans; Isoxazoles; Kinetics; Male; Oxazoles; Phenytoin; Zonisamide

1986
Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells.
    The Journal of biological chemistry, 1986, Nov-15, Volume: 261, Issue:32

    Topics: Animals; Bicarbonates; Carbon Radioisotopes; Cytidine Triphosphate; Guanosine Triphosphate; Isoxazoles; Kinetics; Leukemia L1210; Mice; Naphthoquinones; Oxazoles; Pyrimidines; Uracil Nucleotides

1986
The interaction of potential-sensitive molecular probes with dimyristoylphosphatidylcholine vesicles investigated by 31P-NMR and electron microscopy.
    Biochimica et biophysica acta, 1987, Jan-26, Volume: 896, Issue:2

    Topics: Benzothiazoles; Carbocyanines; Dimyristoylphosphatidylcholine; Indicators and Reagents; Isoxazoles; Kinetics; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membrane Potentials; Microscopy, Electron; Oxazoles; Pyrimidinones; Quinolines

1987
Synthesis of trifluoromethylisoxazoloazines.
    Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1986, Volume: 40, Issue:9

    Topics: Amines; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Phosphorus; Phosphorus Compounds; Pyrimidines

1986
Disease modifying activity of HWA 486 on the development of SLE in MRL/1-mice.
    Agents and actions, 1986, Volume: 19, Issue:5-6

    Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Mice; Mice, Inbred Strains; Oxazoles

1986
Inactivation by acivicin of rat brain CTP and GMP synthetases and depression of CTP and GTP concentrations.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Antibiotics, Antineoplastic; Brain; Carbon-Nitrogen Ligases; Cell Line; Cytidine Triphosphate; Guanosine Triphosphate; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Oxazoles; Rats; Rats, Inbred ACI

1985
The glutamine analog acivicin as antipyrimidine. Studies on the interrelationship between pyrimidine and urea synthesis in liver.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Antibiotics, Antineoplastic; Carbamyl Phosphate; Cytosol; Female; Isoxazoles; Liver; Mitochondria, Liver; Orotic Acid; Oxazoles; Pyrimidines; Rats; Rats, Inbred Strains; Urea

1985
The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen.
    Brain research, 1985, Jul-15, Volume: 338, Issue:2

    Topics: Analgesics; Animals; Baclofen; Central Nervous System; Clonidine; Cordotomy; Isoxazoles; Male; Mice; Morphine; Oxazoles; Oxotremorine

1985
Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity--I. Disease modifying action on adjuvant arthritis of the rat.
    International journal of immunopharmacology, 1985, Volume: 7, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Cyclophosphamide; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Oxazoles; Radiography; Rats; Rats, Inbred Lew

1985
Modification of carboxyl group at the active site of liquefying alpha-amylase.
    Indian journal of biochemistry & biophysics, 1985, Volume: 22, Issue:5

    Topics: alpha-Amylases; Bacillus; Binding Sites; Isoxazoles; Oxazoles; Protein Binding

1985
Synthesis and antibacterial activity of 3-(2-arylvinylen)-2-isoxazolines.
    Il Farmaco; edizione scientifica, 1985, Volume: 40, Issue:5

    Topics: Anti-Bacterial Agents; Escherichia coli; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Staphylococcus aureus; Vinyl Compounds

1985
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801.
    Diabetes, 1985, Volume: 34, Issue:6

    Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Mannoheptulose; Oxazoles; Proinsulin; Rats; Rats, Inbred Strains; Tolbutamide

1985
Blockade of "antiabsence" activity of sodium valproate by THIP in rats with petit mal-like seizures. Comparison with ethosuximide.
    Journal of neural transmission, 1985, Volume: 63, Issue:2

    Topics: Animals; Epilepsy, Absence; Ethosuximide; GABA Antagonists; Injections; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Valproic Acid

1985
Covalent labeling of the nonsubstrate ligand-binding site of glutathione S-transferases with bilirubin-Woodward's reagent K.
    The Journal of biological chemistry, 1986, Apr-25, Volume: 261, Issue:12

    Topics: Animals; Bilirubin; Binding Sites; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Isoxazoles; Liver; Macromolecular Substances; Molecular Weight; Oxazoles; Rats; Spectrometry, Fluorescence; Sulfobromophthalein

1986
Prolongation of gamma-aminobutyric acid-mediated inhibitory postsynaptic potentials by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THPO).
    Neuroscience letters, 1986, Feb-14, Volume: 64, Issue:1

    Topics: Animals; Drug Interactions; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Iontophoresis; Isoxazoles; Neural Inhibition; Nipecotic Acids; Oxazoles; Rats; Synapses

1986
Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma.
    Biochemical pharmacology, 1985, Jan-01, Volume: 34, Issue:1

    Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Colon; Colonic Neoplasms; Glutamine; Humans; Isoxazoles; Kinetics; Ligases; Oxazoles

1985
Oxonol dyes as monitors of membrane potential: the effect of viruses and toxins on the plasma membrane potential of animal cells in monolayer culture and in suspension.
    Journal of cellular physiology, 1985, Volume: 123, Issue:3

    Topics: Animals; Benzothiazoles; Carbocyanines; Cell Membrane; Isoxazoles; Membrane Potentials; Mice; Mice, Inbred Strains; Oxazoles; Toxins, Biological; Virus Diseases

1985
Effect of L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid on urinary excretion of methylmercury in the mouse.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Feces; Glutathione; Isoxazoles; Methylmercury Compounds; Mice; Mice, Inbred CBA; Oxazoles

1985
[A method of quality control of 3-phenyl-5-methylisoxazole-4-carbonic acid chloranhydride using high performance liquid chromatography].
    Antibiotiki i meditsinskaia biotekhnologiia = Antibiotics and medical biotechnology, 1985, Volume: 30, Issue:3

    Topics: Animals; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Female; In Vitro Techniques; Isoxazoles; Male; Oxacillin; Oxazoles; Quality Control; Rabbits; Technology, Pharmaceutical

1985
Blood-brain barrier transport of CI-912: single-passage equilibration of erythrocyte-borne drug.
    Therapeutic drug monitoring, 1985, Volume: 7, Issue:3

    Topics: Animals; Anticonvulsants; Biological Transport; Blood Proteins; Blood-Brain Barrier; Brain; Capillary Permeability; Erythrocytes; Humans; Isoxazoles; Oxazoles; Protein Binding; Rats; Zonisamide

1985
Quantitation of antitumor agent acivicin in plasma by gas chromatography/mass spectrometry.
    Analytical chemistry, 1985, Volume: 57, Issue:11

    Topics: Antibiotics, Antineoplastic; Gas Chromatography-Mass Spectrometry; Humans; Isoxazoles; Oxazoles

1985
Potential biologically active agents. Note II. Synthesis and pharmacological evaluation of some new 3-isoxazolyl-substituted-1,2,3-benzotriazin-4(3H)-ones.
    Bollettino chimico farmaceutico, 1985, Volume: 124, Issue:5

    Topics: Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Edema; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Triazines

1985
WIN 51711, a new systematically active broad-spectrum antipicornavirus agent.
    The Journal of antimicrobial chemotherapy, 1985, Volume: 16, Issue:3

    Topics: Antiviral Agents; Capsid; Isoxazoles; Oxazoles; Picornaviridae; Viral Proteins

1985
Kinetics of Woodward's Reagent K hydrolysis and reaction with staphylococcal nuclease.
    The Journal of biological chemistry, 1974, Jun-25, Volume: 249, Issue:12

    Topics: Benzenesulfonates; Carboxylic Acids; Chemical Phenomena; Chemistry; Computers; Hydrogen-Ion Concentration; Hydrolysis; Hydroxylamines; Imines; Isoxazoles; Mathematics; Methyl Ethers; Models, Chemical; Oxazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Spectrophotometry, Ultraviolet; Staphylococcus

1974
New isoxazolinone amino acids from Lathyrus odoratus seedlings.
    Biochemical and biophysical research communications, 1974, Nov-06, Volume: 61, Issue:1

    Topics: Amino Acids; Chromatography, Ion Exchange; Chromatography, Paper; Deuterium; Fluorescence; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Plants; Quantum Theory; Spectrophotometry, Ultraviolet; Structure-Activity Relationship

1974
[Urovalidin Bracco in the therapy of urinary tract infections in children].
    Ceskoslovenska pediatrie, 1973, Volume: 28, Issue:8

    Topics: Anesthetics, Local; Anti-Infective Agents, Urinary; Cycloserine; Drug Combinations; Drug Evaluation; Humans; Isoxazoles; Oxazoles; Oxazolidinones; Phenazopyridine; Pyridines; Urinary Tract Infections

1973
1,2-Benzisoxazole-3-acetamidoxime hydrochloride, a new psychotropic agent.
    Experientia, 1974, Apr-15, Volume: 30, Issue:4

    Topics: Acetamides; Aggression; Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain Chemistry; Dopamine; Dose-Response Relationship, Drug; Electroencephalography; Female; Humans; Ileum; In Vitro Techniques; Isoxazoles; Norepinephrine; Oxazoles; Oximes; Reserpine; Seizures; Sleep; Tranquilizing Agents

1974
Characteristics and distribution of muscimol binding sites in cat visual cortex.
    Brain research, 1984, Aug-13, Volume: 308, Issue:2

    Topics: Animals; Autoradiography; Cats; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Muscimol; Oxazoles; Receptors, GABA-A; Tissue Distribution; Tritium; Visual Cortex

1984
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
    Pharmacology, biochemistry, and behavior, 1984, Volume: 21, Issue:4

    Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sensory Thresholds

1984
[Potential-dependent interaction of chemical reagents with the sodium channel gating mechanism in a nerve fiber].
    Neirofiziologiia = Neurophysiology, 1984, Volume: 16, Issue:5

    Topics: Animals; Carbodiimides; CME-Carbodiimide; Ethyldimethylaminopropyl Carbodiimide; Hydrogen-Ion Concentration; Ion Channels; Isoxazoles; Membrane Potentials; Nerve Fibers; Oxazoles; Rana ridibunda; Sodium

1984
Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. An electrophysiological study on cultured mouse neurones.
    Neuropharmacology, 1984, Volume: 23, Issue:12A

    Topics: Animals; Benzodiazepines; Carbolines; Cells, Cultured; Convulsants; Electrophysiology; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Mice; Midazolam; Neurons; Oxazoles; Piperidines; Receptors, GABA-A

1984
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
    Research communications in chemical pathology and pharmacology, 1980, Volume: 27, Issue:1

    Topics: Antibiotics, Antineoplastic; Cells, Cultured; gamma-Glutamyltransferase; Glycine; Half-Life; Humans; Isoxazoles; Oxazoles; Pancreatic Neoplasms; Time Factors

1980
The inhibition of gamma-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(alpha S, 5S)-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
    Biochemical and biophysical research communications, 1980, Jun-30, Volume: 94, Issue:4

    Topics: Animals; Cells, Cultured; gamma-Glutamyltransferase; Glutathione; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Rats

1980
The effect of the glutamine analog, AT-125, on the cell cycle of MCF-7 and BT-20 human breast carcinoma cells using DNA flow cytometry.
    Research communications in chemical pathology and pharmacology, 1980, Volume: 29, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line; Cytological Techniques; DNA, Neoplasm; gamma-Glutamyltransferase; Glycine; Humans; Isoxazoles; Oxazoles

1980
Interaction of AT-125, (alpha S,5S)-amino-3-chloro-4,5-dihydroisoxazoleacetic acid, with bovine kidney gamma-glutamyl transpeptidase.
    Chemico-biological interactions, 1981, Volume: 33, Issue:2-3

    Topics: Anilides; Animals; Cattle; gamma-Glutamyltransferase; Glutamates; Glutamine; Glycine; In Vitro Techniques; Isoxazoles; Kidney; Kinetics; Oxazoles

1981
Differential reversal by scopolamine and THIP of the antistereotypic and cataleptic effects of neuroleptics.
    European journal of pharmacology, 1981, Jan-05, Volume: 69, Issue:1

    Topics: Amphetamine; Animals; Antipsychotic Agents; Catalepsy; Humans; Isoxazoles; Male; Oxazoles; Rats; Scopolamine; Stereotyped Behavior

1981
Affinity labeling of gamma-glutamyl transpeptidase by glutamine antagonists. Effects of the gamma-glutamyl transferase and proteinase activities.
    FEBS letters, 1980, Dec-29, Volume: 122, Issue:2

    Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; gamma-Glutamyltransferase; Glycine; Isoxazoles; Kidney; Macromolecular Substances; Oxazoles; Rats; Structure-Activity Relationship

1980
Interaction of the antitumor drug, L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) with renal brush border membranes. Specific labeling of gamma-glutamyl transpeptidase.
    FEBS letters, 1980, Dec-29, Volume: 122, Issue:2

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; gamma-Glutamyltransferase; Glycine; Isoxazoles; Kidney; Male; Microvilli; Molecular Weight; Oxazoles; Rats

1980
Differential effect of AT-125 on rat renal glutaminase activities.
    FEBS letters, 1981, Oct-12, Volume: 133, Issue:1

    Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Phosphates; Rats

1981
Effect of AT-125 on in situ renal gamma-glutamyltransferase activity.
    FEBS letters, 1982, Jul-19, Volume: 144, Issue:1

    Topics: Animals; Antimetabolites; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Isoxazoles; Kidney; Male; Oxazoles; Rats

1982
Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat.
    The Journal of pharmacy and pharmacology, 1982, Volume: 34, Issue:10

    Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Time Factors

1982
The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid.
    Neuroscience letters, 1980, Oct-02, Volume: 19, Issue:3

    Topics: Animals; Anti-Anxiety Agents; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Oxazoles; Piperidines; Rats; Stimulation, Chemical; Temperature; Tritium

1980
The binding mechanism of glutathione and the anti-tumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125;NSC-163501) to gamma-glutamyltransferase.
    Biochemical and biophysical research communications, 1983, Apr-29, Volume: 112, Issue:2

    Topics: Animals; Antineoplastic Agents; Arginine; Binding Sites; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Oxazoles; Phenylglyoxal; Protein Binding; Rats

1983
Absorption, distribution and excretion of 3-(sulfamoyl[14C]methyl)-1,2-benziosoxazole (AD-810) in Rats, Dogs and Monkeys and of AD-810 in Men.
    Arzneimittel-Forschung, 1983, Volume: 33, Issue:7

    Topics: Animals; Autoradiography; Bile; Dogs; Erythrocytes; Female; Humans; Intestinal Absorption; Isoxazoles; Kinetics; Macaca mulatta; Male; Middle Aged; Oxazoles; Pregnancy; Protein Binding; Rats; Rats, Inbred Strains; Species Specificity; Thiazines; Tissue Distribution; Zonisamide

1983
Cardiovascular effects of THIP in the rat.
    The Journal of pharmacy and pharmacology, 1983, Volume: 35, Issue:11

    Topics: Animals; Blood Pressure; Heart Rate; Hemodynamics; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Picrotoxin; Rats; Rats, Inbred Strains

1983
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
    Advances in enzyme regulation, 1982, Volume: 20

    Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Dactinomycin; Deoxyribonucleotides; Glutamine; Humans; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Rats; Rats, Inbred Strains; Ribonucleotides; Sarcoma, Experimental

1982
Synergistic interaction between acivicin (AT-125) and 6-thioguanine in the murine leukemia L1210. Biochemical and cytokinetic considerations.
    Biochemical pharmacology, 1984, Jan-15, Volume: 33, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Guanine Nucleotides; Isoxazoles; Leukemia L1210; Mice; Oxazoles; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thioguanine

1984
Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin.
    Advances in enzyme regulation, 1984, Volume: 22

    Topics: Animals; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Drug; IMP Dehydrogenase; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nucleotides; Oxazoles; Pentosephosphates; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Rats; Ribavirin; Ribonucleosides

1984
The interaction of carboxyl group reagents with the Rhodospirillum rubrum F1-ATPase and its isolated beta-subunit.
    The Journal of biological chemistry, 1983, Mar-25, Volume: 258, Issue:6

    Topics: Adenosine Diphosphate; Adenosine Triphosphate; Calcium; Carbodiimides; Dicyclohexylcarbodiimide; Isoxazoles; Kinetics; Macromolecular Substances; Magnesium; Oxazoles; Phosphates; Photophosphorylation; Proton-Translocating ATPases; Quinolines; Rhodospirillum rubrum

1983
Plasmin-activated prodrugs for cancer chemotherapy. 1. Synthesis and biological activity of peptidylacivicin and peptidylphenylenediamine mustard.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:5

    Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Female; Fibrinolysin; Isoxazoles; Melanoma; Mice; Nitrogen Mustard Compounds; Oligopeptides; Ovarian Neoplasms; Oxazoles; Plasminogen Activators

1983
Therapeutic failure of GABA agonist treatment in Huntington's disease.
    Neurology, 1984, Volume: 34, Issue:5

    Topics: gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoxazoles; Oxazoles

1984
ATP-dependent spectral response of oxonol VI in an ATP-Pi exchange complex.
    Biochimica et biophysica acta, 1984, Aug-31, Volume: 766, Issue:2

    Topics: Animals; Bile Acids and Salts; Cell-Free System; Fluorescent Dyes; Ionophores; Isoxazoles; Mitochondria; Mitochondrial Proton-Translocating ATPases; Oxazoles; Phospholipids; Proton-Translocating ATPases; Sulfhydryl Reagents

1984
Heterogeneous depression of glucose utilization in the caudate nucleus by GABA agonists.
    Brain research, 1981, Mar-30, Volume: 209, Issue:2

    Topics: Animals; Autoradiography; Blood Glucose; Caudate Nucleus; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A

1981
The binding of the GABA agonist [3H]THIP to rat brain synaptic membranes.
    Journal of neurochemistry, 1982, Volume: 38, Issue:4

    Topics: Animals; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes; Tritium

1982
Orally administered THIP inhibits food intake in the rat.
    Behavioral and neural biology, 1982, Volume: 34, Issue:1

    Topics: Administration, Oral; Animals; Bicuculline; Dose-Response Relationship, Drug; Eating; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1982
THIP inhibits feeding behavior in fasted rats.
    Psychopharmacology, 1982, Volume: 76, Issue:1

    Topics: Animals; Dextroamphetamine; Dose-Response Relationship, Drug; Eating; Food Deprivation; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1982
Central cardiovascular effects produced by the GABA receptor agonist drug, THIP.
    Neuropharmacology, 1982, Volume: 21, Issue:6

    Topics: Animals; Autonomic Nervous System; Bicuculline; Blood Pressure; Brain; Cats; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A

1982
Glycine antagonists structurally related to muscimol, THIP, or isoguvacine.
    Journal of neurochemistry, 1982, Volume: 39, Issue:5

    Topics: Animals; Cats; gamma-Aminobutyric Acid; Glycine; Interneurons; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Structure-Activity Relationship

1982
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
    Physiology & behavior, 1982, Volume: 29, Issue:5

    Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine

1982
The acute effect of the GABA-agonist, THIP, on proprioceptive and flexor reflexes in spastic patients.
    Acta neurologica Scandinavica, 1983, Volume: 67, Issue:1

    Topics: Adult; Female; Humans; Isoxazoles; Male; Mechanoreceptors; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Oxazoles; Paraplegia; Proprioception; Reaction Time; Receptors, Cell Surface; Receptors, GABA-A; Reflex, Monosynaptic; Reflex, Stretch

1983
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:6

    Topics: Animals; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes

1983
Diazepam stimulates the binding of GABA and muscimol but not THIP to rat brain membranes.
    Neuroscience letters, 1983, Aug-08, Volume: 38, Issue:3

    Topics: Analgesics; Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A

1983
Antinociceptive effect of the GABAmimetic 4,5,6,7-tetrahydroisoxazolo [5, 4-c]pyridin-3-ol (THIP): chronic treatment increases alpha-2 adrenoceptors in the mouse brain.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 229, Issue:2

    Topics: Analgesics; Animals; Brain Chemistry; Clonidine; Drug Tolerance; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, GABA-A

1984
Microiontophoretically applied THIP effects upon nociceptive responses of neurons in medial thalamus.
    Applied neurophysiology, 1983, Volume: 46, Issue:5-6

    Topics: Animals; Evoked Potentials; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Spinothalamic Tracts; Synaptic Transmission; Tail; Thalamic Nuclei

1983
Effects of THIP on chronic anxiety.
    Psychopharmacology, 1983, Volume: 80, Issue:4

    Topics: Adult; Anxiety Disorders; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Psychiatric Status Rating Scales

1983
Synthesis and antibacterial activity of triazole and isoxazole derivatives of ampicillin.
    The Journal of antibiotics, 1983, Volume: 36, Issue:11

    Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Pseudomonas aeruginosa; Spectrophotometry, Infrared; Structure-Activity Relationship; Triazoles

1983
Methylphenidate, apomorphine, THIP, and diazepam in monkeys: dopamine-GABA behavior related to psychoses and tardive dyskinesia.
    Psychopharmacology, 1984, Volume: 82, Issue:1-2

    Topics: Animals; Apomorphine; Chlorocebus aethiops; Diazepam; Dopamine; Drug Interactions; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Isoxazoles; Male; Methylphenidate; Motor Activity; Oxazoles; Psychoses, Substance-Induced

1984
Substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acids: high-ceiling diuretics with uricosuric activity.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:8

    Topics: Animals; Chlorides; Diuretics; Dogs; Dose-Response Relationship, Drug; Furans; Haplorhini; Isoxazoles; Mice; Models, Molecular; Natriuresis; Oxazoles; Potassium; Rats; Sodium; Stereoisomerism; Structure-Activity Relationship; Uricosuric Agents

1984
Acivicin: a new glutamine antagonist in clinical trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Drug Evaluation; Female; Glutamine; Half-Life; Humans; Isoxazoles; Kinetics; Leukemia, Experimental; Liver Neoplasms, Experimental; Macaca mulatta; Male; Mice; Neoplasms; Oxazoles; Purines; Pyrimidines; Sarcoma, Experimental

1984
Benzisoxazolones: antimicrobial and antileukemic activity.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:9

    Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Isoxazoles; Leukemia L1210; Oxazoles

1984
The carboxyl group in the active center of transketolase.
    Biochemistry international, 1984, Volume: 9, Issue:1

    Topics: Animals; Binding Sites; Carbodiimides; Ethyldimethylaminopropyl Carbodiimide; Hydrogen-Ion Concentration; Indicators and Reagents; Isoxazoles; Kinetics; Muscles; Oxazoles; Rabbits; Spectrophotometry, Ultraviolet; Transketolase

1984
Phase II study of acivicin in colorectal carcinoma: a National Cancer Institute of Canada study.
    Cancer treatment reports, 1984, Volume: 68, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System Diseases; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Hematologic Diseases; Humans; Infusions, Parenteral; Isoxazoles; Male; Middle Aged; Oxazoles; Rectal Neoplasms

1984
[Synthesis and biological properties of isoxazolo[5,4-d]pyrimidine derivatives].
    Acta poloniae pharmaceutica, 1984, Volume: 41, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Central Nervous System; Chemical Phenomena; Chemistry; Humans; Isoxazoles; Oxazoles; Pyrimidines

1984
Nonlinear pharmacokinetics of CI-912 in adult epileptic patients.
    Therapeutic drug monitoring, 1984, Volume: 6, Issue:3

    Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Kinetics; Male; Middle Aged; Oxazoles; Pilot Projects; Zonisamide

1984
Phase I evaluation of AT-125 single dose every three weeks.
    Investigational new drugs, 1984, Volume: 2, Issue:3

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System; Drug Administration Schedule; Drug Evaluation; Glutamine; Humans; Isoxazoles; Middle Aged; Neoplasms; Oxazoles

1984
Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold.
    European journal of pharmacology, 1984, Aug-03, Volume: 103, Issue:1-2

    Topics: Animals; Baclofen; Injections, Spinal; Isoxazoles; Male; Muscimol; Muscle Hypotonia; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds

1984
A new antibiotic Y-T0678H produced by a Chromobacterium species.
    The Journal of antibiotics, 1983, Volume: 36, Issue:7

    Topics: Anti-Bacterial Agents; Bacteria; Chromobacterium; Fermentation; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles

1983
Inhibitory action of 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284) on acetylcholine release from vagus nerve in guinea pig ileum.
    Journal of pharmacobio-dynamics, 1983, Volume: 6, Issue:4

    Topics: Acetylcholine; Animals; Choline; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Isoxazoles; Male; Muscle Contraction; Muscle, Smooth; Oxazoles; Tetrodotoxin; Vagus Nerve; Vas Deferens

1983
Unilateral injection of GABA agonists in the superior colliculus: asymmetry to tactile stimulation.
    Pharmacology, biochemistry, and behavior, 1983, Volume: 19, Issue:2

    Topics: Analgesics; Animals; Baclofen; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Motor Activity; Muscimol; Oxazoles; Physical Stimulation; Rats; Rats, Inbred Strains; Superior Colliculi; Touch

1983
Anorexic and analgesic actions of THIP.
    Advances in biochemical psychopharmacology, 1983, Volume: 37

    Topics: Analgesics; Animals; Appetite Depressants; Behavior, Animal; Benzoquinones; Drug Interactions; Feeding Behavior; Isoxazoles; Male; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time

1983
The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study.
    British journal of clinical pharmacology, 1983, Volume: 16, Issue:5

    Topics: Adult; Aged; Analgesics; Analysis of Variance; Chronic Disease; Drug Evaluation; Female; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Oxazoles; Pain

1983
Pharmacokinetics of the gamma-aminobutyric acid agonist THIP (Gaboxadol) following intramuscular administration to man, with observations in dog.
    Acta pharmacologica et toxicologica, 1983, Volume: 53, Issue:5

    Topics: Absorption; Adult; Animals; Dogs; Humans; Injections, Intramuscular; Isoxazoles; Kinetics; Male; Models, Biological; Oxazoles

1983
Comparison of the analgesic actions of THIP and morphine.
    General pharmacology, 1983, Volume: 14, Issue:6

    Topics: Analgesics; Animals; Atropine; Benzoquinones; Bicuculline; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Morphine; Naloxone; Oxazoles; Quinones; Reaction Time

1983
[3-substituted derivatives of 5-methylisoxazole with antiparasitic effects].
    Ceskoslovenska farmacie, 1983, Volume: 32, Issue:9-10

    Topics: Animals; Anthelmintics; Antifungal Agents; Chemical Phenomena; Chemistry; Helminths; Isoxazoles; Oxazoles

1983
Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist.
    Physiology & behavior, 1983, Volume: 30, Issue:3

    Topics: Aggression; Animals; Arousal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Injections, Intraventricular; Isoxazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time

1983
State of DA/ACh balance after chronic treatment with haloperidol and with THIP in rats.
    Advances in neurology, 1984, Volume: 40

    Topics: Acetylcholine; Animals; Apomorphine; Atropine; Behavior, Animal; Brain; Dopamine; Haloperidol; Isoxazoles; Male; Oxazoles; Physostigmine; Rats; Rats, Inbred Strains

1984
Diazepam enhances the action but not the binding of the GABA analog, THIP.
    Brain research, 1984, Apr-09, Volume: 297, Issue:1

    Topics: Animals; Brain; Chlorides; Culture Techniques; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Ganglia, Spinal; Isoxazoles; Membrane Potentials; Mice; Oxazoles; Rats; Spinal Cord

1984
Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole.
    Cancer research, 1984, Volume: 44, Issue:8

    Topics: Antibiotics, Antineoplastic; Cell Cycle; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Humans; Isoxazoles; Kinetics; Oxazoles; Ribonucleosides; Ribonucleotides

1984
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
    European journal of pharmacology, 1980, Feb-08, Volume: 61, Issue:3

    Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; Mice; Mice, Inbred DBA; Myoclonus; Oxazoles; Papio; Photic Stimulation; Seizures; Time Factors

1980
Isoxazolidine-3,5-diones as lens aldose reductase inhibitors.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:6

    Topics: Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Isoxazoles; Kinetics; Lens, Crystalline; Oxazoles; Rats; Sugar Alcohol Dehydrogenases

1982
Collateral sensitivity to N-(phosphonacetyl)-L-aspartic acid in a line of P388 leukemia cells selected for resistance to L-(alpha S, 5S)-alpha-amino-3- chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
    Cancer research, 1983, Volume: 43, Issue:4

    Topics: Adenine Phosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Ammonia); Drug Resistance; Hypoxanthine Phosphoribosyltransferase; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred Strains; Organophosphorus Compounds; Oxazoles; Phosphonoacetic Acid; Purines; Pyrimidines

1983
Effects of acivicin and dipyridamole on hepatoma 3924A cells.
    Cancer research, 1983, Volume: 43, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Deoxycytidine; Dipyridamole; Isoxazoles; Kinetics; Liver Neoplasms, Experimental; Oxazoles; Rats; Ribonucleosides

1983
Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.
    Acta anaesthesiologica Scandinavica, 1983, Volume: 27, Issue:1

    Topics: Adult; Analgesics; Dental Pulp Test; Double-Blind Method; Hormones; Humans; Hydrocortisone; Isoxazoles; Male; Oxazoles; Pain; Prolactin; Random Allocation; Respiration; Sensory Thresholds

1983
THIP analgesia: cross tolerance with morphine.
    Life sciences, 1983, May-09, Volume: 32, Issue:19

    Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Models, Biological; Morphine; Nipecotic Acids; Oxazoles; Pyrones

1983
Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO.
    Neuropharmacology, 1983, Volume: 22, Issue:1

    Topics: 4-Aminobutyrate Transaminase; Animals; Animals, Newborn; Anticonvulsants; Chickens; Cyclohexanecarboxylic Acids; Isoniazid; Isoxazoles; Male; Mice; Oxazoles; Seizures; Transaminases

1983
A new antibiotic, 3,6-dihydroxyindoxazene.
    The Journal of antibiotics, 1983, Volume: 36, Issue:4

    Topics: Anti-Bacterial Agents; Chromobacterium; Isoxazoles; Oxazoles; X-Ray Diffraction

1983
A comparison of the analgesic activities of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) and 6-chloro-2[1-piperazinyl]pyrazine (MK 212).
    European journal of pharmacology, 1983, Jun-03, Volume: 90, Issue:2-3

    Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Oxazoles; Pyrazines; Time Factors

1983
Quantitative determination of the gamma-aminobutyric acid agonist, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, in serum by high-performance liquid chromatography.
    Journal of chromatography, 1983, May-13, Volume: 274

    Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dogs; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Oxazoles; Papio; Rats; Spectrophotometry, Ultraviolet

1983
Combined action of acivicin and D-galactosamine on pyrimidine nucleotide metabolism in hepatoma cells.
    Biochemical pharmacology, 1983, Jun-15, Volume: 32, Issue:12

    Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Interactions; Female; Galactosamine; In Vitro Techniques; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Pyrimidine Nucleotides; Rats; Rats, Inbred Strains

1983
Phase II trial of acivicin in advanced metastatic breast cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:9

    Topics: Adult; Breast Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1983
Heterocyclic oxyacetic acid diuretics: indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:9

    Topics: Animals; Diuretics; Dogs; Isoxazoles; Mice; Natriuresis; Oxazoles

1983
Pharmacokinetic studies of AD-810, a new antiepileptic compound. Phase I trials.
    Arzneimittel-Forschung, 1982, Volume: 32, Issue:12

    Topics: Adult; Anticonvulsants; Drug Evaluation; Electroencephalography; Erythrocytes; Humans; Isoxazoles; Kinetics; Male; Middle Aged; Oxazoles; Time Factors; Zonisamide

1982
Inhibitory effects of aminoglutethimide and isoxazole on progesterone production and deciduoma formation in rats.
    Endocrinology, 1980, Volume: 107, Issue:2

    Topics: 3-Hydroxysteroid Dehydrogenases; Aminoglutethimide; Animals; Decidua; Female; Isoxazoles; Kinetics; Organ Size; Ovary; Oxazoles; Pregnancy; Progesterone; Rats; Steroids; Sterols; Uterus

1980
[2-alkylaminomethyl-benzoisoxazolin-3-ones].
    Acta poloniae pharmaceutica, 1981, Volume: 38, Issue:1

    Topics: Animals; Antinematodal Agents; Antitrichomonal Agents; Chemical Phenomena; Chemistry; Depression; Drug Evaluation, Preclinical; Humans; Isoxazoles; Mice; Morpholines; Nematoda; Oxazoles; Piperazines; Piperidines; Trichomonas vaginalis

1981
Stability of the isoxazolyl penicillins to staphylococcal beta-lactamase.
    The Journal of antimicrobial chemotherapy, 1982, Volume: 9, Issue:3

    Topics: beta-Lactamases; Drug Stability; Isoxazoles; Oxazoles; Penicillins; Staphylococcus aureus

1982
Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
    The Journal of biological chemistry, 1980, Jul-25, Volume: 255, Issue:14

    Topics: Anthranilate Synthase; Binding, Competitive; Glutamate Synthase; Glutamine; Glycine; Isoxazoles; Kinetics; Nitrogenous Group Transferases; Oxazoles; Serratia marcescens; Transferases

1980
Comparison of the carotenoid bandshift and oxanol dyes to measure membrane potential changes during chemotactic stimulation of Rhodopseudomonas sphaeroides and Escherichia coli.
    FEBS letters, 1981, Apr-06, Volume: 126, Issue:1

    Topics: Carotenoids; Chemotaxis; Coloring Agents; Escherichia coli; Isoxazoles; Membrane Potentials; Oxazoles; Rhodobacter sphaeroides; Spectrophotometry

1981
Modification of the essential amino acids of human pancreatic carboxylic-ester hydrolase.
    Biochimica et biophysica acta, 1982, Jan-04, Volume: 700, Issue:1

    Topics: Carboxylesterase; Carboxylic Ester Hydrolases; Diethyl Pyrocarbonate; Formates; Histidine; Humans; Indicators and Reagents; Isoxazoles; Kinetics; Organophosphorus Compounds; Oxazoles; Pancreas

1982
Catalytic properties of modified human pancreatic carboxylic-ester hydrolase.
    Biochimica et biophysica acta, 1982, Jan-04, Volume: 700, Issue:1

    Topics: Binding Sites; Carboxylesterase; Carboxylic Ester Hydrolases; Diethyl Pyrocarbonate; Glass; Humans; Indicators and Reagents; Isoxazoles; Kinetics; Organophosphorus Compounds; Oxazoles; Pancreas; Protein Binding

1982
Determination of the gamma-aminobutyric acid agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol in urine by high-performance liquid chromatography.
    Journal of chromatography, 1982, Mar-12, Volume: 228

    Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Isoxazoles; Kinetics; Oxazoles; Rats

1982
Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma.
    Life sciences, 1982, Mar-29, Volume: 30, Issue:13

    Topics: Amidophosphoribosyltransferase; Animals; Antimetabolites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Nucleotides; Oxazoles; Pentosyltransferases; Phenotype; Rats; Rats, Inbred ACI

1982
In vivo inactivation by acivicin of carbamoyl-phosphate synthetase II in rat hepatoma.
    Biochemical pharmacology, 1982, Mar-15, Volume: 31, Issue:6

    Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); In Vitro Techniques; Isoxazoles; Kinetics; Ligases; Liver; Liver Neoplasms, Experimental; Magnesium; Male; Oxazoles; Rats; Rats, Inbred ACI

1982
Plasma and cerebrospinal fluid pharmacokinetics of acivicin in Ommaya reservoir-bearing rhesus monkeys.
    Cancer treatment reports, 1982, Volume: 66, Issue:6

    Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Half-Life; Isoxazoles; Kinetics; Macaca mulatta; Male; Methods; Models, Biological; Oxazoles

1982
Isoxicam and related 4-hydroxy-N-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides. Potent nonsteroidal antiinflammatory agents.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Isoxazoles; Male; Oxazoles; Piroxicam; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazines

1982
[(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:1

    Topics: Animals; Diuretics; Dogs; Isoxazoles; Male; Mice; Oxazoles; Structure-Activity Relationship; Uricosuric Agents

1982
Effects of the putative GABAergic agonists, muscimol and THIP, upon local cerebral glucose utilisation.
    Journal of neurochemistry, 1982, Volume: 39, Issue:3

    Topics: Analgesics; Animals; Brain; Deoxy Sugars; Deoxyglucose; gamma-Aminobutyric Acid; Glycolysis; Isoxazoles; Male; Muscimol; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains

1982
Phase I and pharmacological study of acivicin by 24-hour continuous infusion.
    Cancer research, 1982, Volume: 42, Issue:9

    Topics: Antimetabolites; Digestive System; Drug Evaluation; Humans; Infusions, Parenteral; Isoxazoles; Kinetics; Neoplasms; Nervous System; Oxazoles

1982
Effects of acivicin and PALA, singly and in combination, on de novo pyrimidine biosynthesis.
    Advances in enzyme regulation, 1982, Volume: 20

    Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line; Isoxazoles; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nucleic Acids; Organophosphorus Compounds; Orotic Acid; Oxazoles; Phosphonoacetic Acid; Pyrimidines

1982
Differentiation of the analgesic effects of THIP and morphine using three mouse strains.
    Drug and alcohol dependence, 1982, Volume: 9, Issue:3

    Topics: Analgesics; Animals; GABA Antagonists; Hot Temperature; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles

1982
Biochemical pharmacology of acivicin in rat hepatoma cells.
    Biochemical pharmacology, 1982, Nov-01, Volume: 31, Issue:21

    Topics: Animals; Carbon-Nitrogen Ligases; Cell Line; Cell Survival; Cytidine; Deoxycytidine; Deoxyribonucleotides; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Guanosine; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Oxazoles; Rats; Ribonucleotides

1982
Synthesis and topical antiinflammatory activity of some steroidal [16 alpha, 17 alpha-d]Isoxazolidines.
    Journal of medicinal chemistry, 1982, Volume: 25, Issue:12

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Croton Oil; Glucocorticoids; Inflammation; Isoxazoles; Mice; Oxazoles

1982
Comparison of the antinociceptive actions of THIP and morphine.
    Pharmacological research communications, 1982, Volume: 14, Issue:10

    Topics: Analgesics; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Reaction Time; Species Specificity

1982
A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).
    Japanese journal of pharmacology, 1982, Volume: 32, Issue:6

    Topics: Animals; Cecum; Gastric Fundus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Isoxazoles; Male; Muscle Contraction; Muscle, Smooth; Oxazoles; Parasympatholytics; Phrenic Nerve; Trachea; Urinary Bladder

1982
Antinociceptive and anticonvulsive effect of THIP, a pure GABA agonist.
    Polish journal of pharmacology and pharmacy, 1982, Volume: 34, Issue:1-3

    Topics: Analgesics; Animals; Anticonvulsants; Benzoquinones; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time

1982
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Electroencephalographic profile.
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:4

    Topics: Animals; Anticonvulsants; Arousal; Cats; Electroencephalography; Epilepsy; Female; Freezing; Hippocampus; Isoxazoles; Male; Oxazoles; Thalamus; Time Factors; Tungsten; Zonisamide

1980
Analgesic properties of the GABA-mimetic THIP.
    European journal of pharmacology, 1981, Jan-16, Volume: 69, Issue:2

    Topics: Analgesics; Animals; Arthritis, Experimental; Baclofen; Electric Stimulation; Isoxazoles; Macaca mulatta; Mice; Morphine; Muscimol; Oxazoles; Reaction Time

1981
Sex- and age-related mouse toxicity and disposition of the amino acid antitumor agent, acivicin.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 216, Issue:3

    Topics: Age Factors; Animals; Antineoplastic Agents; Female; Glycine; Half-Life; Isoxazoles; Kinetics; Male; Metabolic Clearance Rate; Mice; Oxazoles; Sex Factors; Testosterone; Tissue Distribution

1981
Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
    Cancer research, 1981, Volume: 41, Issue:4

    Topics: Amidohydrolases; Animals; Asparagine; Azo Compounds; Cell Line; Diazooxonorleucine; DNA; Glutamine; Glycine; Isoxazoles; Kinetics; Leukemia L1210; Mice; Oxazoles; Temperature

1981
Effects of 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810) and some antiepileptics on the kindled seizures in the neocortex, hippocampus and amygdala in rats.
    Archives internationales de pharmacodynamie et de therapie, 1981, Volume: 249, Issue:1

    Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electroencephalography; Hippocampus; Isoxazoles; Male; Oxazoles; Rats; Seizures; Zonisamide

1981
Analytical studies on isoxazoles. II A new fluorimetric determination of 5-phenyl-3-isoxazolecarboxylic acid and its application to the determination of perisoxal in plasma.
    Chemical & pharmaceutical bulletin, 1980, Volume: 28, Issue:12

    Topics: Humans; Isoxazoles; Oxazoles; Piperidines; Spectrometry, Fluorescence

1980
[The Hofmann reaction of 3-carbamoyl-5-methylisoxazole (author's transl)].
    Yao xue xue bao = Acta pharmaceutica Sinica, 1981, Volume: 16, Issue:3

    Topics: Isoxazoles; Oxazoles

1981
Increases and decreases in local cerebral glucose utilization in response to GABA agonists.
    European journal of pharmacology, 1981, May-08, Volume: 71, Issue:2-3

    Topics: Animals; Brain; gamma-Aminobutyric Acid; Glucose; Isoxazoles; Male; Muscimol; Oxazoles; Rats

1981
The behavior of the fluorescence lifetime and polarization of oxonol potential-sensitive extrinsic probes in solution and in beef heart submitochondrial particles.
    The Journal of membrane biology, 1981, Volume: 60, Issue:3

    Topics: Adenosine Triphosphate; Alkenes; Animals; Cattle; Energy Metabolism; Ethanol; Fluorescence Polarization; Fluorescent Dyes; Isoxazoles; Magnesium; Magnesium Chloride; Mitochondria; Mitochondria, Heart; Oxazoles; Solutions; Submitochondrial Particles

1981
Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid.
    Cancer research, 1981, Volume: 41, Issue:9 Pt 1

    Topics: Animals; Aspartic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxycytosine Nucleotides; Deoxyribonucleosides; Drug Synergism; Glycine; Isoxazoles; Leukemia L1210; Mice; Organophosphorus Compounds; Orotic Acid; Oxazoles; Phosphonoacetic Acid; Pyrimidines; Ribonucleosides

1981
Reaction of Woodward's Reagent K with pancreatic porcine phospholipase A2: modification of an essential carboxylase residue.
    Biochemical and biophysical research communications, 1981, May-29, Volume: 100, Issue:2

    Topics: Animals; Benzenesulfonates; Binding Sites; Calcium; In Vitro Techniques; Isoxazoles; Models, Chemical; Oxazoles; Pancreas; Phospholipases; Phospholipases A; Phospholipases A2; Swine

1981
Derivatization and purification of acivicin (AT-125, U-42,126).
    The Journal of antibiotics, 1981, Volume: 34, Issue:4

    Topics: Antibiotics, Antineoplastic; Antimetabolites; Glycine; Isoxazoles; Oxazoles

1981
Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, Acivicin (NSC 163501).
    Cancer research, 1981, Volume: 41, Issue:11 Pt 1

    Topics: Cell Count; Cell Division; Cell Line; Cell Survival; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Humans; Interphase; Isoxazoles; Kinetics; Male; Oxazoles; Pancreatic Neoplasms; Time Factors

1981
Paradoxical blockade of a muscimol response by THIP, a GABA agonist and also by GABA-transaminase inhibitors.
    Neuropharmacology, 1981, Volume: 20, Issue:12A

    Topics: 4-Aminobutyrate Transaminase; Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Myoclonus; Oxazoles; Time Factors; Transaminases

1981
Single unit responses of substantia nigra and globus pallidus neurons to GABA agonist and antagonist drugs.
    Advances in biochemical psychopharmacology, 1981, Volume: 30

    Topics: Animals; gamma-Aminobutyric Acid; Globus Pallidus; Iontophoresis; Isoxazoles; Kainic Acid; Male; Muscimol; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Substantia Nigra

1981
Preliminary studies on the absorption, distribution, metabolism, and excretion of THIP in animal and man using 14C-labelled compound.
    Acta pharmacologica et toxicologica, 1981, Volume: 49, Issue:2

    Topics: Absorption; Adult; Animals; Brain; Carbon Radioisotopes; Chromatography, Thin Layer; Half-Life; Humans; Hydrolysis; Isoxazoles; Male; Mice; Mice, Inbred Strains; Middle Aged; Oxazoles; Rats; Rats, Inbred Strains; Tissue Distribution

1981
Isolation of perisoxal glucuronides and determination of enantiomeric ratios of d-and l-perisoxal metabolites excreted in rabbit urine.
    Chemical & pharmaceutical bulletin, 1981, Volume: 29, Issue:12

    Topics: Animals; Glucuronates; Isoxazoles; Male; Oxazoles; Piperidines; Rabbits; Stereoisomerism

1981
Synthesis and biological properties of 5-benzoylamino-3-methyl-4-isoxazolocarboxylic acid derivatives.
    Archivum immunologiae et therapiae experimentalis, 1981, Volume: 29, Issue:6

    Topics: Anti-Inflammatory Agents; Isoxazoles; Oxazoles; Structure-Activity Relationship

1981
Effects of 3-methyl-5-isoxazole carboxylic acid on the plasma volume loss induced by thermal trauma.
    The Journal of trauma, 1980, Volume: 20, Issue:5

    Topics: Animals; Blood Pressure; Burns; Cardiac Output; Dogs; Hematocrit; Isoxazoles; Nicotinic Acids; Oxazoles; Plasma Volume; Time Factors

1980
Modification of the carboxypeptidase A active site residue Glu-270 prevents interaction with a protein protease inhibitor from Ascaris.
    Biochimica et biophysica acta, 1980, Apr-11, Volume: 612, Issue:2

    Topics: Animals; Ascaris; Benzenesulfonates; Binding Sites; Carboxypeptidases; Carboxypeptidases A; Glutamates; Hydrogen-Ion Concentration; Isoxazoles; Oxazoles; Protease Inhibitors; Protein Binding; Structure-Activity Relationship; Tetranitromethane; Tyrosine

1980
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Pharmacological profile.
    Arzneimittel-Forschung, 1980, Volume: 30, Issue:3

    Topics: Animals; Anticonvulsants; Barbiturates; Carbonic Anhydrase Inhibitors; Dogs; Electroshock; Isoxazoles; Motor Activity; Oxazoles; Rabbits; Rats; Seizures; Sleep; Species Specificity; Time Factors; Zonisamide

1980
Oxonol-V as a probe of chromaffin granule membrane potentials.
    Biochimica et biophysica acta, 1980, Jun-20, Volume: 599, Issue:1

    Topics: Absorption; Alkenes; Animals; Biological Transport, Active; Cattle; Chromaffin Granules; Chromaffin System; Fluorescent Dyes; In Vitro Techniques; Isoxazoles; Membrane Potentials; Norepinephrine; Oxazoles

1980
GABAergic actions of THIP in vivo and vitro: a comparison with muscimol and GABA.
    European journal of pharmacology, 1980, Jul-11, Volume: 65, Issue:1

    Topics: Animals; Binding Sites; Brain; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Oxazoles; Rats; Substantia Nigra

1980
Determination of perisoxal and its phenolic metabolites in rat, rabbit and human urine.
    Chemical & pharmaceutical bulletin, 1980, Volume: 28, Issue:7

    Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biotransformation; Female; Humans; Isoxazoles; Oxazoles; Phenols; Piperidines; Rabbits; Rats; Species Specificity

1980
Identification of canine urinary metabolites of the antiprotozoal agent 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole .
    Journal of pharmaceutical sciences, 1980, Volume: 69, Issue:11

    Topics: Animals; Antiprotozoal Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Dogs; Gas Chromatography-Mass Spectrometry; Isoxazoles; Magnetic Resonance Spectroscopy; Nitroimidazoles; Oxazoles

1980
Therapeutic effects of acivicin and N-(phosphonacetyl)-L-aspartic acid in a biochemically designed trial against a N-(phosphonacetyl)-L-aspartic acid-resistant variant of the Lewis lung carcinoma.
    Cancer research, 1981, Volume: 41, Issue:3

    Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carcinoma; Drug Therapy, Combination; Glycine; Isoxazoles; Ligases; Lung Neoplasms; Neoplasms, Experimental; Organophosphorus Compounds; Oxazoles; Phosphonoacetic Acid; Pyrimidines; Rats

1981
The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.
    The Journal of antibiotics, 1995, Volume: 48, Issue:11

    Topics: Animals; Anti-Bacterial Agents; Furans; Humans; Isoxazoles; Mice; Mupirocin; Oxazoles; Pyrazoles; Pyridines; Sepsis; Staphylococcal Infections; Thiazoles; Thiophenes

1995
Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents.
    Journal of medicinal chemistry, 1998, May-21, Volume: 41, Issue:11

    Topics: 3T3 Cells; Animals; Blood Glucose; Cell Differentiation; Drug Evaluation, Preclinical; Hypoglycemic Agents; Insulin; Isoxazoles; L Cells; Male; Malonates; Mice; Oxazoles; Triglycerides

1998
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.
    Chemistry & biology, 1999, Volume: 6, Issue:4

    Topics: Binding Sites; Estradiol; Estrogen Antagonists; Estrogens; Imidazoles; Isoxazoles; Ligands; Models, Molecular; Oxazoles; Piperidines; Protein Conformation; Pyrazoles; Raloxifene Hydrochloride; Receptors, Estrogen; Thiazoles; X-Ray Diffraction

1999
Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles.
    Bioorganic & medicinal chemistry letters, 1999, Sep-20, Volume: 9, Issue:18

    Topics: Anti-Bacterial Agents; Gram-Positive Bacteria; Isoxazoles; Microbial Sensitivity Tests; Oxazoles

1999
Analysis of three structurally related antiviral compounds in complex with human rhinovirus 16.
    Proceedings of the National Academy of Sciences of the United States of America, 1999, Dec-21, Volume: 96, Issue:26

    Topics: Antiviral Agents; Binding Sites; Crystallography; Isoxazoles; Models, Molecular; Oxazoles; Rhinovirus; Structure-Activity Relationship; Tetrazoles

1999
Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists.
    Arteriosclerosis, thrombosis, and vascular biology, 2000, Volume: 20, Issue:4

    Topics: Abciximab; Alanine; Amidines; Antibodies, Monoclonal; Blood Coagulation; Blood Platelets; Elasticity; Fibrin; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Nephelometry and Turbidimetry; Oxazoles; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Sulfonamides; Thrombelastography; Thromboplastin; Viscosity

2000
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses.
    Antiviral research, 2000, Volume: 47, Issue:3

    Topics: Antiviral Agents; Cell Survival; Cells, Cultured; Common Cold; Humans; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; Spectrophotometry; Valine

2000
Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective
    Journal of medicinal chemistry, 2003, Jan-02, Volume: 46, Issue:1

    Topics: Administration, Oral; Animals; Blood Pressure; Caco-2 Cells; Carotid Arteries; CHO Cells; Cricetinae; Endothelin Receptor Antagonists; Humans; In Vitro Techniques; Isoxazoles; Macaca fascicularis; Male; Muscle Contraction; Oxazoles; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Structure-Activity Relationship; Sulfonamides

2003
Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes.
    Drug metabolism and disposition: the biological fate of chemicals, 2003, Volume: 31, Issue:8

    Topics: Air; Amidines; Animals; Carbon Monoxide; Chemistry Techniques, Analytical; Cytochrome P-450 Enzyme System; Electrons; Indoles; Isoxazoles; Ketoconazole; Microsomes, Liver; Molecular Structure; NADP; Oxazoles; Oxidation-Reduction; Rats; Structure-Activity Relationship

2003
[Condensation of isonicotinic & cyanacetic acid hydrazides with several isoxazole ketones. II].
    Il Farmaco; edizione scientifica, 1958, Volume: 13, Issue:11

    Topics: Hydrazines; Isoniazid; Isoxazoles; Ketones; Oxazoles

1958
SYNERGISM OF D-4-AMINO-3-ISOXAZOLIDONE AND O-CARBAMYL-D-SERINE.
    The Journal of antibiotics, 1964, Volume: 17

    Topics: Anti-Bacterial Agents; Bacillus subtilis; Isoxazoles; Mycobacterium; Mycobacterium tuberculosis; Oxazoles; Oxazolidinones; Pharmacology; Research; Serine; Staphylococcus

1964
STEROIDAL HETEROCYCLES. VII. ANDROSTANO(2,3-D)ISOXAZOLES AND RELATED COMPOUNDS.
    Journal of medicinal chemistry, 1963, Volume: 6

    Topics: Anabolic Agents; Castration; Chemistry, Pharmaceutical; Isoxazoles; Muscles; Oxazoles; Pharmacology; Rats; Research; Steroids

1963
[REACTIVITY OF DICARBONYL-ISOXAZOLES. VI. TRANSFORMATION OF 3-CARBONYL-ISOXAZOLE OXIMES INTO FURAZAN DERIVATIVES].
    La Ricerca scientifica. 2. ser., pt. 2: Rendiconti. Sezione B: Biologica, 1964, Volume: 5

    Topics: Chemistry, Pharmaceutical; Isoxazoles; Oxadiazoles; Oxazoles; Oximes; Pharmacy; Research

1964
ISOXAZOLES. XVI. THE REACTION OF NITROUS ACID ON 5-AMINO-3,4-DIALKYLISOXAZOLES.
    Chemical & pharmaceutical bulletin, 1964, Volume: 12

    Topics: Chemistry, Pharmaceutical; Isoxazoles; Nitrites; Nitrous Acid; Oxazoles; Research

1964
[A DERIVATIVE OF ISOXAZOLE. I. ON REACTIONS BETWEEN DIKETENE AND HYDROXYLAMINE OR SOME HYDROXAMIC ACIDS].
    Chemical & pharmaceutical bulletin, 1965, Volume: 13

    Topics: Chemistry, Pharmaceutical; Hydroxamic Acids; Hydroxylamine; Hydroxylamines; Isoxazoles; Ketones; Lactones; Oxazoles; Research

1965
Human rhinovirus capsid dynamics is controlled by canyon flexibility.
    Virology, 2003, Sep-15, Volume: 314, Issue:1

    Topics: Antibodies, Viral; Antigen-Antibody Reactions; Binding Sites; Capsid; HeLa Cells; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Microscopy, Electron; Models, Molecular; Mutation; Oxadiazoles; Oxazoles; Rhinovirus; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Virus Assembly

2003
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
    Laboratory investigation; a journal of technical methods and pathology, 2003, Volume: 83, Issue:10

    Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Growth Factors; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lymphokines; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrobenzenes; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma 180; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors

2003
Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines.
    Bioorganic & medicinal chemistry, 2004, Dec-15, Volume: 12, Issue:24

    Topics: Anti-Bacterial Agents; Antifungal Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Isoxazoles; Mitosporic Fungi; Oxazoles; Structure-Activity Relationship

2004
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
    Bioorganic & medicinal chemistry letters, 2005, May-02, Volume: 15, Issue:9

    Topics: Dipeptidyl Peptidase 4; Isoxazoles; Oxazoles; Piperidines; Protease Inhibitors; Pyrazoles; Thiazoles

2005
Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.
    Bioorganic & medicinal chemistry, 2007, Jun-01, Volume: 15, Issue:11

    Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents, Tricyclic; Humans; Isoxazoles; Male; Oxazoles; Pyrazines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors

2007
Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-Ins deacetylase.
    Journal of medicinal chemistry, 2007, Dec-13, Volume: 50, Issue:25

    Topics: Amidohydrolases; Bacterial Proteins; Binding Sites; Cysteine; Furans; Glycopeptides; Inositol; Isoxazoles; Models, Molecular; Mycobacterium tuberculosis; Oxazines; Oxazoles; Protein Binding; Pyrans; Stereoisomerism; Sulfonamides; Thioglycosides

2007
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
    Journal of medicinal chemistry, 2008, Mar-13, Volume: 51, Issue:5

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Binding Sites; Biological Availability; Capillary Permeability; Cell Line; Cell Line, Tumor; Edema; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Models, Molecular; NIH 3T3 Cells; Oxazoles; Phenylurea Compounds; Phosphorylation; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Structure-Activity Relationship; Uterus; Xenograft Model Antitumor Assays

2008
New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3.
    Antiviral research, 2009, Volume: 81, Issue:1

    Topics: Antiviral Agents; Drug Design; Drug Resistance, Viral; Enterovirus B, Human; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Mutation; Oxadiazoles; Oxazoles

2009
The versatile electrophilic reactivity of 4,6-dinitrobenzo[d]isoxazole-3-carbonitrile.
    Organic & biomolecular chemistry, 2009, Mar-21, Volume: 7, Issue:6

    Topics: Dimethyl Sulfoxide; Isoxazoles; Kinetics; Methanol; Molecular Structure; Nitriles; Oxazoles; Stereoisomerism; Thermodynamics

2009
The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds.
    Chemical communications (Cambridge, England), 2010, Nov-28, Volume: 46, Issue:44

    Topics: Aldehyde Dehydrogenase; Bacterial Proteins; Isomerism; Isoxazoles; Oxazoles; Staphylococcus aureus

2010
Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation.
    Bioorganic & medicinal chemistry letters, 2011, Jan-01, Volume: 21, Issue:1

    Topics: Animals; Brain; Cell Differentiation; Humans; Isoxazoles; Multiple Sclerosis; Oligodendroglia; Oxazoles; PPAR delta; Rats; Transcriptional Activation

2011
Photochemistry and vibrational spectra of matrix-isolated methyl 4-chloro-5-phenylisoxazole-3-carboxylate.
    The journal of physical chemistry. A, 2011, Feb-24, Volume: 115, Issue:7

    Topics: Argon; Computer Simulation; Energy Transfer; Isoxazoles; Models, Molecular; Molecular Conformation; Molecular Structure; Oxazoles; Photochemistry; Quantum Theory; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Temperature; Thermodynamics; Ultraviolet Rays; Vibration; Xenon

2011
Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazoles.
    Future medicinal chemistry, 2010, Volume: 2, Issue:2

    Topics: Amines; Anticonvulsants; Antipsychotic Agents; Benzoxazoles; Isoxazoles; Microwaves; Oxazoles; Time Factors

2010
Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Antioxidants; Biphenyl Compounds; Free Radicals; Isoxazoles; Nitric Oxide; Oxazoles; Picrates; Pyrazoles; Thiazoles

2011
Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.
    Bioorganic & medicinal chemistry, 2012, Apr-01, Volume: 20, Issue:7

    Topics: Antitubercular Agents; Isomerism; Isoxazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazoles; Pyridines; Structure-Activity Relationship; Thiazoles

2012
Trade-offs in defensive metabolite production but not ecological function in healthy and diseased sponges.
    Journal of chemical ecology, 2012, Volume: 38, Issue:5

    Topics: Animal Diseases; Animals; Anti-Bacterial Agents; Bacteria; Caribbean Region; Chromatography, High Pressure Liquid; Feeding Behavior; Isoxazoles; Oxazoles; Porifera; Spiro Compounds; Tetraodontiformes; Tyrosine

2012
Capture of an elusive nitrile ylide as an intermediate in isoxazole-oxazole photoisomerization.
    The Journal of organic chemistry, 2013, Nov-01, Volume: 78, Issue:21

    Topics: Isoxazoles; Molecular Structure; Nitriles; Oxazoles; Spectrophotometry, Ultraviolet; Stereoisomerism; Temperature; Ultraviolet Rays

2013
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C.
    Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:3

    Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication

2014
Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
    PloS one, 2014, Volume: 9, Issue:9

    Topics: Animals; Axons; Cell Count; Demyelinating Diseases; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Female; Isoxazoles; Macrophages; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; NF-kappa B; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxazoles; Peptide Fragments; Pyrimidinones; Signal Transduction; Spinal Cord; T-Lymphocytes

2014
Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells.
    Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2016, Volume: 19, Issue:1

    Topics: Antineoplastic Agents; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Isoxazoles; Molecular Targeted Therapy; Oxazoles; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Resorcinols; Stomach Neoplasms; Transforming Growth Factor beta1; Triazoles

2016
Isoxazole to oxazole: a mild and unexpected transformation.
    Chemical communications (Cambridge, England), 2015, Jan-21, Volume: 51, Issue:6

    Topics: Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Isoxazoles; Molecular Structure; Oxazoles

2015
4,5-Substituted 3-Isoxazolols with Insecticidal Activity Act as Competitive Antagonists of Housefly GABA Receptors.
    Journal of agricultural and food chemistry, 2015, Jul-22, Volume: 63, Issue:28

    Topics: Animals; Binding, Competitive; GABA Antagonists; Gene Expression; Houseflies; Insecticides; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Oocytes; Oxazoles; Receptors, GABA; Xenopus laevis

2015
Mechanistic Analysis of an Isoxazole-Oxazole Photoisomerization Reaction Using a Conical Intersection.
    The journal of physical chemistry. A, 2015, Sep-17, Volume: 119, Issue:37

    Topics: Isoxazoles; Models, Chemical; Molecular Structure; Oxazoles; Photochemical Processes; Quantum Theory; Stereoisomerism

2015
Strong deshielding in aromatic isoxazolines.
    Magnetic resonance in chemistry : MRC, 2016, Volume: 54, Issue:1

    Topics: Acridines; Chlorobenzenes; Crystallography, X-Ray; Cyclization; Isoxazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Nitriles; Oxazoles; Peptides, Cyclic; Stereoisomerism

2016
Function-Oriented Synthesis: How to Design Simplified Analogues of Antibacterial Nucleoside Natural Products?
    Chemical record (New York, N.Y.), 2016, Volume: 16, Issue:3

    Topics: Anti-Bacterial Agents; Biological Products; Drug Design; Enterococcus; Isoxazoles; Microbial Sensitivity Tests; Nucleosides; Oxazoles; Staphylococcus aureus; Structure-Activity Relationship

2016
Replacement of Oxygen by Sulfur in Small Organic Molecules. 3. Theoretical Studies on the Tautomeric Equilibria of the 2OH and 4OH-Substituted Oxazole and Thiazole and the 3OH and 4OH-Substituted Isoxazole and Isothiazole in the Isolated State and in Solu
    International journal of molecular sciences, 2016, Jul-09, Volume: 17, Issue:7

    Topics: Isomerism; Isoxazoles; Models, Theoretical; Oxazoles; Solutions; Sulfur; Thermodynamics; Thiazoles

2016
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound.
    Bioorganic & medicinal chemistry letters, 2016, 10-01, Volume: 26, Issue:19

    Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Half-Life; Inhibitory Concentration 50; Isoxazoles; Membrane Transport Proteins; Oxazoles; Piperidines; Rats; Structure-Activity Relationship

2016
Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.
    Acta pharmacologica Sinica, 2016, Volume: 37, Issue:12

    Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Heterografts; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasm Transplantation; Oxazoles; Quinazolines; Resorcinols

2016
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
    Journal of medicinal chemistry, 2017, 01-26, Volume: 60, Issue:2

    Topics: Active Transport, Cell Nucleus; Animals; Binding Sites; Cell Nucleus; Dogs; HEK293 Cells; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Humans; Imidazoles; Isoxazoles; Mice; NF-kappa B p50 Subunit; NF-kappa B p52 Subunit; NF-kappaB-Inducing Kinase; Oxazepines; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Signal Transduction

2017
Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice.
    Journal of pharmaceutical and biomedical analysis, 2018, Sep-05, Volume: 158

    Topics: Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme System; Drug Monitoring; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Neoplasms; Oxazoles; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Tandem Mass Spectrometry; Xenograft Model Antitumor Assays

2018
Automated cell-based luminescence assay for profiling antiviral compound activity against enteroviruses.
    Scientific reports, 2019, 04-15, Volume: 9, Issue:1

    Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Enterovirus; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Luminescent Measurements; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Valine; Vero Cells

2019
Rational design, synthesis and structure-activity relationship of novel substituted oxazole isoxazole carboxamides as herbicide safener.
    Pesticide biochemistry and physiology, 2019, Volume: 157

    Topics: Acetolactate Synthase; Enzyme Activation; Glutathione; Glutathione Transferase; Herbicides; Isoxazoles; Oxazoles; Structure-Activity Relationship; Sulfonamides; Triazines; Zea mays

2019
Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring.
    European journal of medicinal chemistry, 2021, Jan-01, Volume: 209

    Topics: Allosteric Site; Animals; Electrons; Electrophysiological Phenomena; Humans; Isoxazoles; Ligands; Oocytes; Oxazoles; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfonamides; Thiazoles; Xenopus laevis

2021
The In Vitro Impact of Isoxazole Derivatives on Pathogenic Biofilm and Cytotoxicity of Fibroblast Cell Line.
    International journal of molecular sciences, 2023, Feb-03, Volume: 24, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Biofilms; Cell Line; Fibroblasts; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Pseudomonas aeruginosa; Staphylococcus aureus

2023