oxazoles has been researched along with isoxazoles in 521 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 450 (86.37) | 18.7374 |
| 1990's | 25 (4.80) | 18.2507 |
| 2000's | 19 (3.65) | 29.6817 |
| 2010's | 25 (4.80) | 24.3611 |
| 2020's | 2 (0.38) | 2.80 |
| Authors | Studies |
|---|---|
| Fotsch, C; St Jean, DJ | 1 |
| Gale, KN; Guidotti, A | 1 |
| Diamantis, W; Ludwig, BJ; Sofia, RD | 2 |
| Waddington, JL | 1 |
| Sato, M; Stammer, CH | 1 |
| Kuo, YH; Lambein, F; van Parijs, R | 1 |
| Bashford, CL; Chance, B; Prince, RC | 1 |
| Ballard, F; Kucharczyk, N; Myers, G; Sofia, RD; Yang, J | 1 |
| Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Utsui, Y; Yoshida, K | 2 |
| Arison, BH; Eskola, P; Kulsa, P; Miller, AK; Miller, BM; Miller, TW; Mrozik, H; Skeggs, H; Vandenheuvel, WJ; Zimmerman, SB | 1 |
| Charlton, M; Goldblatt, D; Joynt, RJ; Shoulson, I | 1 |
| Curtis, DR; Johnston, GA; Krogsgaard-Larsen, P; Lodge, D | 1 |
| Biggio, G; Brodie, BB; Costa, E; Guidotti, A | 1 |
| Beaumont, K; Chilton, WS; Enna, SJ; Yamamura, HI | 1 |
| Snodgrass, SR | 1 |
| Arnt, J; Krogsgaard-Larsen, P | 1 |
| Chance, B; Smith, JC | 1 |
| Bashford, CL; Chance, B; Smith, JC; Yoshida, T | 1 |
| Douglas, JF; Edelson, J; Ludwig, BJ | 1 |
| Banerjee, BN; Ivins, NJ; Ludwig, BJ; Sofia, RD | 1 |
| Mizojiri, K; Nakajima, Y; Okabe, H; Sugeno, K; Watanabe, J; Yamamoto, R | 1 |
| Grover, V; Joshi, KC; Pathak, VN | 1 |
| Grover, V; Pathak, VN | 1 |
| Kanazawa, M; Kawasaki, K; Ogiwara, T; Sato, K; Tsuyuzaki, K | 1 |
| Diamantis, W; Edelson, J; Gordon, R; Ludwig, BJ; Sofia, RD | 1 |
| Csapo, AI; Csapo, EF; Resch, B; Salau, G | 1 |
| Berger, AE; Bloch, A; Grindey, GB; McPartland, RP; Neil, GL | 1 |
| Bogden, AE; Houchens, DP; Johnson, RK; Neil, GL; Ovejera, AA; Sheridan, MA | 1 |
| Akerman, KE; Wolff, CH | 1 |
| Csapo, AI; Resch, BA | 1 |
| Holcenberg, JS | 1 |
| Karobath, M; Lippitsch, M | 1 |
| Andrews, PR; Johnston, GA | 1 |
| Kolasa, K | 1 |
| Saunders, JC; Williamson, WR | 1 |
| Gupta, RC; Kishor, K; Pandey, BR; Srivastava, VK | 1 |
| Curtis, DR; Johnston, GA; Lodge, D | 1 |
| Boissier, JR; Dumont, C; Oberlander, C | 1 |
| Cools, AR; Scheel-Krũger, J; van Wel, PM | 1 |
| Koella, WP; Olpe, HR | 1 |
| Arnt, J; Christensen, AV; Scheel-Krüger, J | 2 |
| Lakoski, JM; Walters, JR | 1 |
| Hori, N; Ikeda, K; Roberts, E | 1 |
| Leach, MJ; Wilson, JA | 1 |
| Hashimoto, M; Utsui, Y; Yamaguchi, T | 1 |
| DiPasquale, G; Gingold, J; Rassaert, C; Schwartz, E; Welaj, P | 1 |
| Yarbrough, GG | 1 |
| Johnston, GA; Krogsgaard-Larsen, P | 2 |
| Berger, AE; Bhuyan, BK; Blowers, CL; Kuentzel, SL; Neil, GL | 1 |
| Ravagnan, G; Salfi, V; Strom, R | 1 |
| Berlin, KD; Chesnut, RW; Durham, NN; Hashem, MM | 1 |
| Berlin, KD; Chesnut, RW; Durham, NN; Mawdsley, EA | 1 |
| Nicoletti, M; Ravagnan, G; Renzini, G; Strom, R | 1 |
| Bella, DD; Biggio, G; Frigeni, V; Guidotti, A | 1 |
| Cools, AR; Honig, W; Scheel-Krüger, J | 1 |
| El-Rabbat, NA; Omar, NM | 1 |
| Carr, JB; Durham, HG; Hass, DK | 1 |
| Hines, JW; Stammer, CH | 1 |
| Biggio, G; Casu, M; Corda, MG; Gessa, GL; Vernaleone, F | 1 |
| Stamm, H; Steudle, H | 3 |
| Gorecki, DK; Peesker, SJ; Wood, JD | 1 |
| Beam, CF; Dasher, LW; Harris, CE; Shealy, KD; Shealy, NL | 1 |
| Hashimoto, S; Shizu, M; Takahashi, S | 1 |
| Chance, B; Cooperman, BS; Russ, P; Smith, JC | 1 |
| Cheney, DL; Costa, E; Zsilla, G | 1 |
| DiPasquale, G; Rassaert, C; Tripp, L; Welaj, P | 1 |
| Bausi, L; Bramanti, G; Maoggi, M; Renzi, G | 1 |
| Furukawa, K; Karasawa, T; Shimizu, M; Yoshida, K | 1 |
| Ito, T; Shimizu, M; Yoshida, K | 1 |
| Douglas, JF; Edelson, J; Ludwig, BJ; Schuster, EB; Shahinian, S | 1 |
| Ansbacher, R | 1 |
| Schunack, W | 1 |
| Baczysnkyj, L; Chidester, CG; Duchamp, DJ; Martin, DG; Mizsak, SA | 1 |
| Albrecht, HP; Moffatt, JG; Repke, DB | 1 |
| Belter, PA; Coleman, TA; Gerpheid, SA; Hanka, LJ; Martin, DG; Meyer, HF; Spieles, PR | 1 |
| Goldman, AS; Shapiro, BH | 1 |
| Denzel, T; Janssen, W | 1 |
| Arena, F; Manna, F; Parente, L; Stein, ML | 1 |
| Abignente, E; De Caprariis, P; Stein, ML | 1 |
| DiPasquale, G; Gingold, J; Rassaert, C; Richter, R; Singer, R; Welaj, P | 1 |
| Minami, N; Suzuki, Y | 1 |
| Furukawa, H; Hayashi, Y; Imai, K; Matsuura, M | 1 |
| Bodin, JI; Brenner, IA; Reisberg, P | 1 |
| Freedman, JC; Novak, TS; Pratap, PR | 1 |
| Lau, SS; Monks, TJ | 1 |
| Ishii, H; Kalbe, K; Kurooka, S; Naruto, S; Nishimura, S; Sunahara, N | 1 |
| Cao, LQ; Chance, WT; Fischer, JE | 1 |
| Miyake, H; Ono, N; Sunami, A; Yamamoto, N; Yamasaki, Y | 1 |
| Charles, CL; Stoesz, L; Tollefson, G | 1 |
| Edwards, WD; Lefler, BJ; Natale, NR; Palmer, RB; Triggle, DJ | 1 |
| Jodogne, C; Tirelli, E | 1 |
| Bailey, TR; Diana, GD; Dutko, FJ; Oglesby, RC; Pevear, DC; Treasurywala, AM | 1 |
| Boeyé, A; Brioen, P; Rombaut, B | 1 |
| Bruce, D; Cooper, CE; Nicholls, P | 1 |
| Belhage, B; Hansen, GH; Meier, E; Schousboe, A | 4 |
| de Tarlovsky, MN; Goijman, SG; Molina Portela, MP; Stoppani, AO | 1 |
| Allen, SD; Bennett, GA; Georgiev, VS; Mitchell, JT; Mullen, GB; Swift, PA | 1 |
| Dan, T; Koga, H; Tanaka, H | 1 |
| Allen, SD; Kinsolving, CR; Maryniak, DM; Mitchell, JT; Mullen, GB; St Georgiev, V | 3 |
| Christopherson, RI; Lyons, SD; Sant, ME | 1 |
| Hasegawa, H; Okuda, H; Wada, Y; Yamaguchi, N | 1 |
| Bhaduri, A; Mukherjee, T; Roy, K | 1 |
| Bailey, H; Earhart, RH; McGovren, JP; Williams, MG | 1 |
| Ardalan, B; Chandrasekaran, B; Hrishikeshavan, HJ | 1 |
| Hanson, RL; Isaacson, CM | 1 |
| Chused, TM; Wilson, HA | 1 |
| Prajda, N | 1 |
| Naumov, AP; Neguliaev, IuA; Vedernikova, EA | 1 |
| Schauf, CL | 1 |
| Apell, HJ; Bersch, B | 1 |
| Awouters, F; Janssen, PA; Meert, TF; Megens, AA; Niemegeers, CJ; Schellekens, KH | 1 |
| de Chaffoy de Courcelles, D; Eens, A; Gommeren, W; Janssen, PA; Leysen, JE; Stoof, JC | 1 |
| Awouters, FH; Megens, AA; Niemegeers, CJ | 1 |
| de Haes, P; Janssen, PA; Meert, TF | 1 |
| Burton, P; Gelders, Y; Heylen, S; Mesotten, F; Pietquin, M; Suy, E | 1 |
| de Bruyckere, K; Janssen, PF; Leysen, JE; Schotte, A | 1 |
| Dugovic, C; Janssen, PA; Wauquier, A | 1 |
| Duncan, JS; Hart, YM; Sander, JW; Shorvon, SD | 1 |
| Gonsalves, SF; Harbaugh, RE; Krogsgaard-Larsen, P; Schousboe, A; Twitchell, B | 1 |
| Guidinger, PL; Jubelt, B; McKinlay, MA; Ropka, SL; Wilson, AK | 1 |
| Badger, J; Dutko, FJ; Fancher, M; Heinz, BA; McKinlay, MA; Rossmann, MG; Rueckert, RR; Shepard, DA; Smith, TJ | 1 |
| Bruns, RF; Drummond, J; Johnson, G; Nickell, DG; Ortwine, DF; Welbaum, B | 1 |
| Agmo, A; Paredes, R; Soria, P | 1 |
| Diana, GD; Dutko, FJ; McKinlay, MA; Otto, MJ; Rogge, MC; Woods, MG | 1 |
| Della Bella, D | 1 |
| Löfdahl, CG; Sigvaldasson, A; Skoogh, BE; Svedmyr, N | 1 |
| Bianco, S | 1 |
| Ziment, I | 1 |
| Allegra, L | 1 |
| Ikegami, T; Natsumeda, Y; Weber, G | 1 |
| Ardalan, B; Deas, M; Jayaram, HN; Johnson, RK | 1 |
| Mellor, JM; Mills, GA; Walker, V | 1 |
| Allen, SD; Bennett, GA; DeCory, TR; Jones, WE; Maryniak, DM; Mitchell, JT; Mullen, GB; St Georgiev, V | 1 |
| Allen, SD; Bennett, GA; Mitchell, JT; Mullen, GB; St Georgiev, V | 2 |
| Berger, R; Schierbeek, H | 1 |
| Bartlett, RR; Langer, KH; Schleyerbach, R; Sitter, T; Thoenes, GH | 1 |
| Andersen, JV; Dalgaard, L; Hansen, SH | 1 |
| Dwivedi, B; Tiwari, N | 1 |
| Allen, SD; Georgiev, VS; Mitchell, JT; Mullen, GB | 1 |
| Allen, SD; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA | 1 |
| Einspahr, FJ; McGovren, JP; Piercey, MF; Schreur, PJ; Tang, AH; VonVoigtlander, PF; Williams, MG | 1 |
| Futami, H; Irino, S; Shiotani, T; Yamaji, Y; Yamauchi, N | 1 |
| Briñon, MC; de Bertorello, MM; Longhi, MR | 1 |
| Genchi, G; Palmieri, F; Wolf, G | 1 |
| Allen, SD; Kinsolving, CR; Mitchell, JT; Mullen, GB; Ordy, MJ; Palmer, GC; Radov, LA; Simmons, RD; St Georgiev, V; Strand, JC | 1 |
| Kandul, SV; Sinitskaia, TA | 1 |
| Callens, M; De Bruyne, CK; Kersters-Hilderson, H; Vangrysperre, W | 1 |
| Carenzi, A; Chiarino, D; Napoletano, M; Reggiani, A; Sala, A; Sala, R | 1 |
| Liske, S; Morris, ME | 1 |
| Chitneni, SR; Moore, JO; Nichols, KE; Weinberg, JB | 1 |
| Davis, TE; Earhart, RH; Faraggi, D; Khandekar, JD; Schinella, RA | 1 |
| Habermehl, KO; McKinlay, MA; Otto, MJ; Willingmann, P; Zeichhardt, H | 1 |
| Fujimoto, M; Guidotti, A; Hanbauer, I; Kataoka, Y | 1 |
| Diana, GD; Maliski, EG; McKinlay, MA; Oglesby, RC; Otto, MJ; Rossmann, MG; Smith, TJ; Treasurywala, AM | 1 |
| Cosi, C; Wood, PL | 1 |
| Spealman, RD; Wettstein, JG | 1 |
| Itoh, N; Mimaki, T; Suzuki, Y; Tagawa, T; Tanaka, J; Yabuuchi, H | 1 |
| Byberg, JR; Curtis, DR; Falch, E; Gynther, BD; Hjeds, H; Krogsgaard-Larsen, P; Labouta, IM | 1 |
| Capraro, MA; Hughey, RP | 1 |
| Burk, RF; Hill, KE; Von Hoff, DD | 1 |
| Allen, RC; Dunn, RW; Ellis, DB; Gardner, BA; Glamkowski, EJ; Huger, FP; Jones, MC; Schmid, BL; Stache, U; Strupczewski, JT | 1 |
| Corsico, R; Lodola, E; Majani, U; Rampulla, C | 1 |
| Hansen, SH; Krogsgaard-Larsen, P; Nielsen, EO; Schousboe, A | 1 |
| Catt, JD; Eison, MS; Lobeck, WG; Minielli, JL; New, JS; Riblet, LA; Smith, DW; Taylor, DP; Temple, DL; Yevich, JP | 1 |
| Bruno, G; Chase, TN; Cox, C; Fedio, P; Foster, N; Gillespie, M; Hare, TA; Mohr, E; Tamminga, C | 1 |
| Carenzi, A; Chiarino, D; Della Bella, D; Fantucci, M; Frigeni, V; Sala, R | 1 |
| Sastrasinh, M; Sastrasinh, S | 2 |
| Bianco, S; Robuschi, M; Simone, P; Vaghi, A; Ventresca, GP | 1 |
| Curthoys, NP; Scott, RD | 1 |
| Bründler, H; Godly, R; Herzog, H; Imhof, E; Perruchoud, AP | 1 |
| Harris, C; Juchau, MR; Stark, KL | 1 |
| Cafaggi, R; D'Onofrio, V; Giosuè, S; Guerrini, P; Perrone, N; Scano, M | 1 |
| Casali, L; Colombo, ML; Manazza, P; Rossi, A; Zoia, MC | 1 |
| Davis, ME | 1 |
| Chetta, A; Cuomo, A; Garavaldi, G; Gurrieri, G; Olivieri, D | 1 |
| Aoki, T; Oya, H | 2 |
| Akullian, V; Cutcliffe, D; Diana, GD; Mallamo, JP; McKinlay, MA; Oglesby, RC; Otto, MJ | 1 |
| Bagri, A; Di Scala, G; Sandner, G | 1 |
| Hjeds, H; Krogsgaard-Larsen, P; Sarhan, S; Schousboe, A; Seiler, N | 1 |
| Falch, E; Krogsgaard-Larsen, P; Larsson, OM; Schousboe, A | 1 |
| Costa, LG; Enna, SJ; Pelley, K; Setler, P; Vaught, JL | 1 |
| Brisson, CJ; Diana, GD; McKinlay, MA; Miralles, JV; Salvador, UJ; Zalay, ES | 1 |
| Gähwiler, BH; Graff, P; Maurer, R; Nordmann, R | 1 |
| Diana, GD; Fancher, MJ; Fox, MP; Kuhrt, MF; McKinlay, MA; Otto, MJ | 1 |
| Akullian, V; Diana, GD; McKinlay, MA; Oglesby, C; Otto, MJ | 1 |
| Depaulis, A; Vergnes, M | 2 |
| Hösli, E; Hösli, L; Krogsgaard-Larsen, P | 1 |
| Brehm, L; Curtis, DR; Falch, E; Johansen, JS; Krogsgaard-Larsen, P; Schaumburg, K | 1 |
| Chweh, AY; Swinyard, EA; Ulloque, RA | 1 |
| Ryan, TM; Zoutendam, PH | 1 |
| Belhage, B; Meier, E; Schousboe, A | 1 |
| Braestrup, C; Krogsgaard-Larsen, P; Nielsen, M | 1 |
| Fox, MP; McKinlay, MA; Otto, MJ | 1 |
| Eisenhauer, E; Maksymiuk, A; Maroun, JA; Pater, J; Stewart, DJ; Young, V | 1 |
| Akullian, V; Carabateas, PM; Cutcliffe, D; Diana, GD; Maliski, EG; Mallamo, JP; McKinlay, MA; Michalec, SJ; Oglesby, RC; Otto, MJ | 1 |
| Shavrin, AS; Zharkovskaia, TA; Zharkovskiĭ, AM | 1 |
| Apud, JA; Masotto, C; Racagni, G | 1 |
| Chweh, AY; Swinyard, EA; Wolf, HH | 1 |
| Enna, SJ; Zorn, SH | 2 |
| Gillis, RA; Hamosh, P; Hartley, B; Quest, JA; Taveira da Silva, AM | 1 |
| Allen, SD; Dormer, PA; Mitchell, JT; Mullen, GB; St Georgiev, V | 1 |
| Löscher, W | 1 |
| Cao, L; Chance, WT; Fischer, JE; Foley-Nelson, T; Nelson, JL | 1 |
| Gumnit, RJ; Henry, TR; Jacobs, M; Leppik, IE | 1 |
| Hirschelmann, R; Schade, R | 1 |
| Cao, L; Chance, WT; Fischer, JE | 1 |
| Ogawa, K; Yamawaki, I | 1 |
| Kawasaki, T; Shimizu, A; Tanaka, M; Yamada, Y; Yamamoto, J | 1 |
| Hagendoorn, MJ; Kraayenhof, R; Krab, K; van Walraven, HS | 1 |
| Brunner, EA; Cheng, SC | 1 |
| Capizzi, RL; Craig, JB; Powell, BL; Richards, F | 1 |
| Carbone, PP; Davis, TE; Earle, JD; Elson, PJ; Glover, DJ; Hahn, RG; Kvols, LK; Trump, DL; Vogl, SE | 1 |
| Allen, SD; DeCory, TR; Georgiev, VS; Kinsolving, CR; Mitchell, JT; Mullen, GB | 1 |
| Basson, M; Ernst, LA; Freedman, JC; George, EB; Nyirjesy, P; Pratap, PR; Waggoner, AS | 1 |
| Kochetov, GA; Kuimov, AN | 1 |
| Bennett, GA; DeCory, TR; Dormer, PG; Maryniak, DM; Mullen, GB; St Georgiev, V; Swift, PA | 1 |
| Allen, SD; Kinsolving, CR; Maryniak, DM; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA | 1 |
| Allen, SD; DeCory, TR; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V | 1 |
| Allen, SD; DeCory, TR; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA | 1 |
| Allen, SD; Bennett, GA; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V; Swift, PA | 3 |
| Allen, SD; Bennett, GA; Kinsolving, CR; Mitchell, JT; Mullen, GB; St Georgiev, V | 1 |
| Allen, SD; Mitchell, JT; Mullen, GB; St Georgiev, V | 2 |
| Allen, SD; Bennett, GA; DeCory, TR; Mitchell, JT; Mullen, GB; St Georgiev, V | 1 |
| Ishibashi, M; Miyazaki, H; Mizugaki, M; Nakagawa, Y; Sagi, M; Takayama, H; Yamanaka, H | 1 |
| Krogsgaard-Larsen, P; Schousboe, A; Wood, JD | 1 |
| Baumann, K; Binder, D; Holzer, W; Noe, CR | 2 |
| Barsoum, NJ; DiFonzo, CJ; Macallum, GE; Smith, GS; Walker, RM | 1 |
| Basson, M; Freedman, JC; George, EB; Gupta, RK; Nyirjesy, P; Pratap, PR; Raman, K; Waggoner, AS | 1 |
| Freedman, JC; George, EB; Nyirjesy, P; Pratap, PR; Waggoner, AS | 1 |
| Luther, RR; Patterson, KJ; Ringham, GL; Thomas, EW; Tolman, KG | 1 |
| Lisgarten, JN; Palmer, RA | 1 |
| Allen, SD; Kinsolving, CR; Mullen, GB; Ordy, JM; Palmer, GC; Simmons, RD; St Georgiev, V; Strand, JC | 1 |
| Cao, L; Chance, WT; Fischer, JE; Kim, MW; Nelson, JL | 1 |
| Flaim, SF; Maryanoff, BE; McKenna, JI; Natale, NR; Schlicksupp, L; Willett, RD | 1 |
| Emrani, J; Hashimoto, Y; Ikegami, T; Natsumeda, Y; Prajda, N; Reardon, MA; Szondy, S; Weber, G | 1 |
| Borsini, F; Giuliani, S; Meli, A | 1 |
| Huber, KR; Roberts, J; Rosenfeld, H | 1 |
| Friberg, L; Roland, PE | 1 |
| Cortez, C; DiGiovanni, J; Harvey, RG; Sawyer, TW | 1 |
| Dannhardt, G; Grobe, A; Gussmann, S; Obergrusberger, R; Ziereis, K | 1 |
| Drower, EJ; Hammond, DL | 2 |
| Dain, JG; Jaffe, JM; Orwig, BA; Tse, FL | 1 |
| Sweet, F; Varga, B | 1 |
| Furukawa, K; Hori, M; Ito, T; Kadokawa, T; Karasawa, T; Matsuno, Y; Noda, Y; Ochi, Y; Oka, M | 1 |
| Fujitani, B; Ito, T; Kadokawa, T; Matsuno, Y; Nakamura, N; Nakatsuji, K | 1 |
| Depaulis, A; Liebeskind, JC; Morgan, MM | 1 |
| Fukuda, H; Ito, S; Kurashige, S; Miyazaki, H; Mizugaki, M; Narita, K; Sakamoto, T; Tatee, T; Yamanaka, H | 2 |
| Eisenhauer, EA; Fields, AL; Maroun, JA; Walde, PL | 1 |
| Adhikari, VA; Badiger, VV | 1 |
| Georgiev, VS; Mullen, GB; Swift, PA | 1 |
| Avioli, LV; Civitelli, R; Halstead, LR; Hruska, KA; Reid, IR | 1 |
| Bartlett, RR | 1 |
| Buyniski, JP; Gylys, JA; Pasternak, RD; Siminoff, P; Wadopian, NS; Wright, RN | 1 |
| Maniwa, M; Marunaka, T | 1 |
| Birch, R; Greco, A; Johnson, R; Kramer, BS; Prestridge, K | 1 |
| Chang, YC; Falkson, G; Knuiman, MW; Pandya, KJ; Skeel, RT; Willson, JK; Wolter, JM | 1 |
| Booth, BW; Budman, D; Ellison, RR; Khojasteh, A; Korzun, AH; Weiss, RB; Wood, W | 1 |
| Brewer, JM; Sinha, U | 1 |
| Hammond, EJ; McLean, JR; Perchalski, RJ; Wilder, BJ | 1 |
| Juergens, U | 1 |
| Massacesi, M; Pinna, R; Ponticelli, G; Puggioni, G | 1 |
| Borden, EC; Falkson, G; Simson, IW; Vorobiof, DA | 1 |
| Bañez, M; Ciciani, G; Dal Piaz, V; Torroba, T; Vadillo, S; Valle, J | 1 |
| Balsamini, C; Duranti, E; Scheda, P | 1 |
| Huber, KR; Mayer, EP; Mitchell, DF; Roberts, J | 1 |
| Kanai, S; Kitani, K; Masuda, Y; Nokubo, M; Ohta, M; Sato, Y | 1 |
| Zarkovsky, AM | 1 |
| Liebeskind, JC; Morgan, MM; Stein, C | 1 |
| Jaffe, JM; Orwig, B; Tse, FL | 1 |
| Kadokawa, T; Kawashima, K; Mizuta, H; Naruto, S; Ueda, S; Yoshida, T | 1 |
| Jørgensen, OS; Meier, E; Schousboe, A | 1 |
| Albini, E; Carenzi, A; Chiarino, D; Della Bella, D; Napoletano, M; Sala, A | 1 |
| Borsini, F; Evangelista, S; Meli, A | 1 |
| Blessing, JA; Buchsbaum, HJ; DiSaia, PJ; McGuire, WP | 1 |
| Meder, J; Rehse, K | 1 |
| Martin, DG; Mizsak, SA; Nielsen, JW | 1 |
| Ito, S; Kurashige, S; Miyazaki, H; Mizugaki, M; Narita, K; Sakamoto, T; Shiozawa, A; Takei, M; Tatee, T; Yamanaka, H | 1 |
| Adolphson, CC; Ajani, JA; Barlogie, B; Bedikian, AY; Bodey, GP; Korinek, J; Stroehlein, JR | 1 |
| McKinlay, MA; Steinberg, BA | 1 |
| Engler, J; Hjeds, H; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD | 1 |
| Hirate, K; Shinozaki, H | 1 |
| Benziger, DP; Frank, JA; McKinlay, MA; Steinberg, BA | 1 |
| Buchanan, RA; Friel, PN; Levy, RH; McLean, JR; Ojemann, LM; Shastri, RA; Wilensky, AJ | 1 |
| Christopherson, RI; Kemp, AJ; Lyons, SD | 1 |
| Bammel, BP; Brand, JA; Evans, D; Simmons, RB; Smith, JC | 1 |
| Pedersen, EB; Tanaka, K | 1 |
| Bartlett, RR; Popovic, S | 1 |
| Achleitner, E; Lui, MS; Weber, G | 1 |
| Gerok, W; Häussinger, D; Holstege, A; Pausch, J; Rasenack, J | 1 |
| Bartlett, RR; Schleyerbach, R | 1 |
| Dua, RD; Kochhar, S | 1 |
| Blandino, G; Pappalardo, MS; Ronsisvalle, G; Vittorio, F | 1 |
| Ardalan, B; Belt, RJ; Benjamin, RS; McGovren, JP; Ohnuma, T; Pratt, EA; Taylor, SA | 1 |
| Earhart, RH; Neil, GL | 1 |
| Boyajy, LD; Hanson, RL; Isaacson, CM | 1 |
| Marescaux, C; Micheletti, G; Rumbach, L; Vergnes, M; Warter, JM | 1 |
| Boyer, TD | 1 |
| Dingledine, R; Korn, SJ | 1 |
| Aoki, T; Eble, JN; Glover, JL; Sebolt, JS; Weber, G | 1 |
| Alder, GM; Bashford, CL; Gray, MA; Micklem, KJ; Pasternak, CA; Taylor, CC; Turek, PJ | 1 |
| Kostyniak, PJ; Mulder, KM | 1 |
| Mezentsev, AS; Ostashevich, NE; Panina, MA; Vtorov, IB | 1 |
| Cornford, EM; Landon, KP | 1 |
| McGovren, JP; Roach, BL; Robins, RH; Williams, MG | 1 |
| Bajardi, ML; Daidone, G; Plescia, S; Raffa, D | 1 |
| McKinlay, MA | 1 |
| Anfinsen, CB; Dunn, BM | 1 |
| Lambein, F; Van Parijs, R | 1 |
| Janda, J | 1 |
| Karasawa, T; Masuda, M; Oka, M; Shimizu, M; Yoshida, K | 1 |
| Cynader, M; Needler, MC; Shaw, C | 1 |
| Minchin, MC; Nutt, DJ | 1 |
| Mozhaeva, GN; Naumov, AP; Nosyreva, ED | 1 |
| Jensen, MS; Lambert, JD | 1 |
| Allen, L; Meck, R; Yunis, A | 1 |
| Ellis, WW; Meck, RA; Reed, DJ | 1 |
| Allen, LM; Thornthwaite, JT | 1 |
| Allen, LM; Corrigan, MV; Meinking, T | 1 |
| Arnt, J; Christensen, AV | 1 |
| Gardell, SJ; Tate, SS | 1 |
| Kozak, EM; Tate, SS | 1 |
| Curthoys, NP; Shapiro, RA | 1 |
| Dass, PD; Welbourne, TC | 1 |
| Casey, DE; Gerlach, J; Hetmar, O; Kaldan, B; Korsgaard, S; Mikkelsen, LB | 1 |
| Forchetti, MC; Guidotti, A; Krogsgaard-Larsen, P; Moroni, F | 1 |
| Karobath, M; Supavilai, P | 1 |
| Curthoys, NP; Reed, DJ; Schasteen, CS | 1 |
| Fujii, T; Hashimoto, M; Kagemoto, A; Maeda, T; Matsumoto, K; Miyazaki, H | 1 |
| Persson, B | 1 |
| Aoki, T; Burt, ME; Denton, JE; Faderan, MA; Lui, MS; Prajda, N; Reardon, MA; Sebolt, J; Weber, G; Zhen, YS | 1 |
| Bhalla, K; Deitch, A; Grant, S; Nayak, R | 1 |
| Elliott, WL; Faderan, MA; Liepnieks, JJ; Lui, MS; Natsumeda, Y; Weber, G | 1 |
| Gromet-Elhanan, Z; Khananshvili, D | 1 |
| Carl, PL; Chakravarty, PK; Katzenellenbogen, JA; Weber, MJ | 1 |
| Chase, TN; Denaro, A; Foster, NL; Hare, TA; Tamminga, CA | 1 |
| Cross, AJ; Waddington, JL | 1 |
| Hanstein, WG; Kiehl, R | 1 |
| Kelly, PA; McCulloch, J | 2 |
| Aaes-Jørgensen, T; Bøgesø, KP; Krogsgaard-Larsen, P; Mikkelsen, H; Schultz, B | 1 |
| Brehm, L; Krogsgaard-Larsen, P; Schaumburg, K | 1 |
| Falch, E; Krogsgaard-Larsen, P | 1 |
| Blavet, N; Clostre, F; DeFeudis, FV | 1 |
| Blavet, N; Clostre, F; De Feudis, FV | 1 |
| Dias Souza, J; Gillis, RA; Quest, JA; Williford, DJ | 1 |
| Curtis, DR; Hjeds, H; Krogsgaard-Larsen, P; Leah, JD; Peet, MJ | 1 |
| Christensen, AV; Krogsgaard-Larsen, P; Svendsen, O | 1 |
| Blavet, N; DeFeudis, FV | 1 |
| Mondrup, K; Pedersen, E | 1 |
| Curtis, DR; Falch, E; Jacobsen, P; Krogsgaard-Larsen, P; Leah, JD; Mikkelsen, H; Peet, MJ | 1 |
| Johnston, GA; Skerritt, JH | 1 |
| Costa, LG; Murphy, SD | 1 |
| Dafny, N; Reyes-Vázquez, C | 1 |
| Bank-Mikkelsen, OK; Valentin, N | 1 |
| Hoehn-Saric, R | 1 |
| Altmann, H; Dose, M; Emrich, HM; von Zerssen, D | 1 |
| Iwagami, H; Sasaki, Y; Yasuda, N | 1 |
| Bjørndal, N; Christensson, E; Gerlach, J | 1 |
| Bunnell, PR; Crowley, SR; Dodge, PW; Fung, AK; Pariza, RJ; Parks, JA; Pernet, AG; Plattner, JJ | 1 |
| Alonso, MT; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Evans, BR; Wierenga, W; Zurenko, GE | 1 |
| Kabakov, AN; Kochetov, GA; Kuimov, AN; Meshalkina, LE; Tsorina, ON | 1 |
| Cripps, C; Eisenhauer, E; Fields, AL; Maroun, JA; Pater, JL; Stewart, DJ | 1 |
| Machoń, Z; Ryng, S | 2 |
| Berent, S; Donofrio, PD; Sackellares, JC; Sakmar, E; Wagner, JG | 1 |
| Belt, RJ; Haas, CD; Hoogstraten, B; Joseph, U; Taylor, S | 1 |
| Imai, H; Iwanami, M; Miyazaki, S; Suzuki, K; Tanaka, K; Watanabe, S | 1 |
| Sone, H; Takayanagi, I | 1 |
| Di Scala, G; Karli, P; Schmitt, P | 1 |
| DeFeudis, FV | 1 |
| Kjaer, M; Nielsen, H | 1 |
| Følsgård, S; Jacobsen, E; Lindeburg, T; Madsen, SM; Sillesen, H | 1 |
| DeFeudis, FV; Grognet, A; Hertz, F | 3 |
| Danĕk, J; Spaldonová, R; Sváb, A; Zikán, V | 1 |
| Agnoli, A; Chase, TN; Denaro, A; Ruggieri, S; Tamminga, CA | 1 |
| Macdonald, RL; Skerritt, JH | 1 |
| Bittner, G; Fischer, PH; Pamukcu, R; Willson, JK | 1 |
| Horton, R; Meldrum, B | 1 |
| Maragoudakis, ME; Richon, AB; Wasvary, JS | 1 |
| Ardalan, B; Jayaram, HN; Johnson, RK | 1 |
| Lui, MS; Weber, G; Zhen, YS | 1 |
| Følsgård, S; Jacobsen, E; Kehlet, H; Lindeburg, T; Sillesen, H | 1 |
| Andree, T; Enna, SJ; Kendall, DA | 1 |
| Johnson, DD; Krogsgaard-Larsen, P; Schousboe, A; Wood, JD | 1 |
| Dam, M; Jensen, I; Petersen, HR | 1 |
| Gomi, S; Hamada, M; Iinuma, K; Iitaka, Y; Ikeda, D; Ikeda, T; Ikeda, Y; Kondo, S; Nakamura, H; Takeuchi, T; Umezawa, H | 1 |
| Cheney, DL; McGill, W; Murray, TF | 1 |
| Madsen, SM | 1 |
| Keppler, DO; Leube, K | 1 |
| Bodey, G; Fleishman, G; Murphy, WK; Yap, HY | 1 |
| Allen, RC; Försch, MF; Setescak, LL; Shutske, GM; Wilker, JC | 1 |
| Ishida, S; Ito, T; Kakegawa, N; Miyazaki, H; Seino, M; Sekine, Y; Shimizu, M; Wada, T; Yagi, K; Yamaguchi, T | 1 |
| Inaba, T; Wiest, WG | 1 |
| Bień, I; Domagalina, E | 1 |
| Lacey, R | 1 |
| Bower, SG; Tso, JY; Zalkin, H | 1 |
| Maugh, TH | 1 |
| Armitage, JP; Evans, MC | 1 |
| Bruno, S; McGovren, JP; Neil, GL; Penta, J; Poster, DS | 1 |
| Lombardo, D | 2 |
| Hansen, SH; Schultz, B | 1 |
| Aoki, T; Denton, JE; Lui, MS; Sebolt, J; Weber, G | 1 |
| Aoki, T; Sebolt, J; Weber, G | 1 |
| Elfring, GL; McGovren, JP; Poplack, DG; Smith, RB; Soares, N; Stewart, JC; Von Hoff, DD; Wood, JH | 1 |
| DiPasquale, G; Fabian, AC; Genzer, JD; Kasulanis, CF; Lindo, N; Lutomski, C; Schwartz, ML; Shavel, J; Sircar, JC; Zinnes, H | 1 |
| Allen, RC; Davis, L; Effland, RC; Kitzen, JM; Novick, WJ; Ranbom, K; Setescak, LL; Shutske, GM; Wilker, JC | 1 |
| Kufe, DW; McGovren, JP; Schade, D; Weiss, GR | 1 |
| Cooney, DA; Jayaram, HN; Kensler, TW | 1 |
| Kizaki, H; Lui, MS; Weber, G | 1 |
| Berkenkoph, J; Fernandez, X; Friary, R; Green, MJ; Lutsky, BN; Monahan, M; Tiberi, RL | 1 |
| Kadokawa, T; Kawashima, K; Sohji, Y; Sone, H; Takayanagi, I | 1 |
| Christensen, AV; Larsen, JJ | 1 |
| Hori, M; Ito, T; Masuda, Y; Shimizu, M; Yoshida, K | 1 |
| Buescher, HH; Hill, RC; Maurer, R; Roemer, D | 1 |
| Chan, PJ; McGovren, JP; Neil, GL; Stewart, JC | 1 |
| Roberts, J; Rosenfeld, H | 1 |
| Kamei, C; Masuda, Y; Oka, M; Shimizu, M; Yoshida, K | 1 |
| Hirai, E; Imanishi, H; Umeda, T | 1 |
| Li, YG; Ma, LT; Wang, X | 1 |
| Kuhar, MJ; London, ED; Palacios, JM; Rapoport, SI | 1 |
| Hallidy, L; Smith, JC; Topp, MR | 1 |
| Kufe, DW; Loh, E | 1 |
| Dinur, D; Hajdu, J; Kantrowitz, ER | 1 |
| Biles, C; Martin, DG; Mizsak, SA | 1 |
| Allen, LM; Clubb, KJ; Meck, RA; Yunis, AA | 1 |
| Menon, MK | 1 |
| Bergstrom, DA; Walters, JR; Waszczak, BL | 1 |
| Aaes-Jørgensen, T; Bøgesø, KP; Jørgensen, A; Schultz, B | 1 |
| Mizojiri, K; Nakajima, Y; Okabe, H; Sugeno, K; Watanabe, J; Yamamoto, E | 2 |
| Hilton, JG | 1 |
| Homandberg, GA; Minor, ST; Peanasky, RJ | 1 |
| Hori, M; Karasawa, T; Masuda, Y; Shimizu, M; Shiraishi, Y; Yoshida, K | 1 |
| Henry, JP; Scherman, D | 1 |
| Hruska, RE; Walters, JR; Waszczak, BL | 1 |
| Arison, BH; Kirkman-Bey, N; Onofrey, D; Pile, J; Vandenheuvel, WJ; Zweig, JS | 1 |
| Cooney, DA; Kensler, TW; Reck, LJ | 1 |
| Broom, NJ; Elder, JS; Hannan, PC; O'Hanlon, PJ; Pons, JE; Walker, G; Wilson, J; Woodall, P | 1 |
| Iwao, M; Onogi, S; Shibata, T; Shinkai, H; Tanaka, M; Uchida, I; Wakitani, K | 1 |
| Aron, ZD; Fink, BE; Katzenellenbogen, JA; Mortensen, DS; Stauffer, SR | 1 |
| Cho, YS; Choi, JH; Choi, KI; Joo, HJ; Kim, BH; Kim, HY; Koh, HY; Pae, AN | 1 |
| Diana, GD; Hadfield, AT; Rossmann, MG | 1 |
| Forsythe, MS; Khurana, S; Mousa, SA | 1 |
| Crump, CE; Hayden, FG; Kaiser, L | 1 |
| Turner, RB | 1 |
| Gersten, M; Hsyu, PH; Kerr, BM; Penning, CA; Pithavala, YK | 1 |
| Dalvie, DK; Kalgutkar, AS; Khojasteh-Bakht, SC; O'Donnell, JP; Obach, RS | 1 |
| Barrish, JC; Bird, E; Chen, P; Chong, S; Gu, Z; Hermsmeier, M; Humphreys, WG; Koplowitz, B; Leith, L; Liu, EC; Marino, A; Mathur, A; Moreland, S; Morrison, RA; Murugesan, N; Spergel, S; Trippodo, N; Waldron, T; Webb, ML; Young, M; Zhang, R | 1 |
| Tschirret-Guth, RA; Wood, HB | 1 |
| FEDI, M; GIANNINI, M | 1 |
| TANAKA, N; UMEZAWA, H | 1 |
| ACKERMAN, JH; ARNOLD, A; BEYLER, AL; CHRISTIANSEN, RG; CLARKE, RL; CLINTON, RO; DEAN, JW; MANSON, AJ; NEUMANN, HC; PAGE, DF; PHILLIPS, DK; POTTS, GO; STONNER, FW | 1 |
| AIELLO, T; FABRA, J; SPRIO, V | 1 |
| ADACHI, I; KANO, H; YAMAZAKI, E | 1 |
| KOCHETKOV, NK; SOKOLOV, SD | 1 |
| FUJIMOTO, M; SAKAI, M | 1 |
| Chase, E; Harris, K; Katpally, U; Reisdorph, N; Siuzdak, G; Smith, TJ; Thomas, JJ | 1 |
| Amano, H; Hayashi, I; Inukai, M; Kamata, M; Kitasato, H; Majima, M; Yoshida, S; Yoshimura, H | 1 |
| Chi-Burris, K; Gersten, M; Gwaltney, JM; Hayden, FG; Hsyu, P; Patick, AK; Smith, GJ; Turner, RB; Zalman, LS | 1 |
| Hitesh, NA; Mallesha, H; Rangappa, KS; Sadashiva, MP | 1 |
| Ashton, WT; Dong, H; Doss, GA; He, H; Leiting, B; Lyons, KA; Marsilio, F; Patel, RA; Sisco, RM; Thornberry, NA; Weber, AE; Wu, JK | 1 |
| Alcázar, J; Alonso, JM; Alvarez, RM; Andrés, JI; Bakker, MH; Biesmans, I; Cid, JM; De Lucas, AI; Drinkenburg, W; Fernández, J; Font, LM; Iturrino, L; Langlois, X; Lenaerts, I; Martínez, S; Megens, AA; Pastor, J; Pullan, S; Steckler, T | 1 |
| Tao, J; Zhao, L | 1 |
| Moreira, R; Santos, MM | 1 |
| Bewley, CA; Fetterolf, BJ; Gutierrez-Lugo, MT; Metaferia, BB; Moravec, M; Ray, S; Shazad-Ul-Hussan, S; Smith, JA | 1 |
| Ahmed, AA; Albert, DH; Bouska, JJ; Bousquet, PF; Cunha, GA; Davidsen, SK; Diaz, G; Glaser, KB; Guo, J; Harris, CM; Ji, Z; Li, J; Marcotte, PA; Michaelides, MR; Moskey, MD; Oie, T; Pease, L; Soni, NB; Stewart, KD | 1 |
| Makarov, VA; Riabova, OB; Schmidtke, M; Wutzler, P; Zieger, R | 1 |
| Cottyn, B; Goumont, R; Shevelev, S; Starosotnikov, A; Terrier, F; Vichard, D | 1 |
| Chiacchio, U; Corsaro, A; Merino, P; Romeo, G | 1 |
| Böttcher, T; Orth, R; Sieber, SA | 1 |
| Endo, T; Kanda, T; Nakamura, H; Sakuma, S; Yamakawa, T; Yamasaki, S | 1 |
| Fausto, R; Gómez-Zavaglia, A; Lopes, S; Nunes, CM; Pinho e Melo, TM | 1 |
| Deadman, J; Jones, ED; Le, G; Smith, JA | 1 |
| Muralikrishna, A; Padmaja, A; Padmavathi, V; Rajasekhar, C | 1 |
| Boshoff, H; Chang, M; Cho, S; Franzblau, SG; Hwang, CH; Markley, LD; Miller, MJ; Moraski, GC | 1 |
| Gochfeld, DJ; Kamel, HN; Olson, JB; Thacker, RW | 1 |
| Fausto, R; Nunes, CM; Reva, I | 1 |
| Aguayo, E; Birkus, G; Cihlar, T; Jordan, R; Lee, G; Mello, C; Rodriguez, M | 1 |
| Bertolotto, A; Finardi, A; Furlan, R; Hintermann, S; Martire, S; Montarolo, F; Perga, S; Raffaele, C | 1 |
| Bujak, A; Dymek, B; Dzwonek, K; Grygielewicz, P; Gunerka, P; Lamparska-Przybysz, M; Stanczak, A; Wieczorek, M; Zdzalik, D | 1 |
| Chatterley, A; Elsegood, MR; Jones, RC; Marty, R; Owton, WM | 1 |
| Furuta, K; Liu, G; Ozoe, F; Ozoe, Y | 1 |
| Su, MD | 1 |
| Imrich, J; Kožíšek, J; Ungvarská Maľučká, L; Vilková, M | 1 |
| Ichikawa, S | 1 |
| Nagy, PI | 1 |
| Bertron, JL; Blakely, RD; Blobaum, AL; Dickerson, JW; Ennis, EA; Lindsley, CW; Locuson, CW; Rook, JM; Tarr, CJ; Wright, J | 1 |
| Chen, DQ; Ding, J; Geng, MY; Liu, HC; Shen, AJ; Shen, JK; Sun, JY; Wang, X; Wang, YQ; Xiong, B; Zhang, MM; Zheng, M | 1 |
| Beresini, M; Blaquiere, N; Bravo, B; Brightbill, H; Castanedo, GM; Chen, J; Cui, HF; Eigenbrot, C; Everett, C; Feng, J; Godemann, R; Gogol, E; Hymowitz, S; Johnson, A; Kayagaki, N; Knüppel, K; Kohli, PB; Kraemer, J; Krüger, S; Loke, P; McEwan, P; Montalbetti, C; Roberts, DA; Smith, M; Staben, ST; Steinbacher, S; Sujatha-Bhaskar, S; Takahashi, R; Wang, X; Wu, LC; Zhang, Y | 1 |
| Cheng, C; Jia, Y; Jin, X; Liu, Y; Wang, G; Yao, L; Zhang, J; Zhou, F | 1 |
| Lv, W; Wang, Y; Zhang, M; Zhang, Y | 1 |
| Fu, Y; Gao, S; Kang, T; Li, JJ; Wu, SL; Ye, F; Zhai, Y; Zhao, LX | 1 |
| Rajan, R; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B | 1 |
| Bąchor, U; Brożyna, M; Junka, A; Mączyński, M | 1 |
17 review(s) available for oxazoles and isoxazoles
| Article | Year |
|---|---|
Mitigating heterocycle metabolism in drug discovery.
Topics: Animals; Biotransformation; Databases, Factual; Drug Discovery; Drug Interactions; Heterocyclic Compounds, 1-Ring; Heterocyclic Compounds, 4 or More Rings; Humans; Mice; Pharmaceutical Preparations; Rats | 2012 |
Broxaterol: pharmacological profile of a unique structural feature.
Topics: Adrenergic beta-Agonists; Animals; Asthma; Bronchodilator Agents; Humans; Isoxazoles; Oxazoles; Structure-Activity Relationship | 1989 |
Role of broxaterol in bronchial hyperresponsiveness.
Topics: Adrenergic beta-Agonists; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Bronchodilator Agents; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic | 1989 |
Broxaterol: therapeutic trials and safety profile.
Topics: Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Child; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic | 1989 |
GABA uptake inhibitors: relevance to antiepileptic drug research.
Topics: Animals; Anticonvulsants; Brain; Epilepsy; gamma-Aminobutyric Acid; Isoxazoles; Molecular Conformation; Neurotransmitter Uptake Inhibitors; Oxazoles | 1987 |
Neuropharmacology of zonisamide, a new antiepileptic drug.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Carbonic Anhydrase Inhibitors; Drug Interactions; Epilepsy; Isoxazoles; Kinetics; Oxazoles; Zonisamide | 1987 |
Acivicin in 1985.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Humans; Isoxazoles; Kinetics; Male; Nervous System; Oxazoles | 1985 |
THIP, isoguvacine, isoguvacine oxide, and related GABA agonists.
Topics: Animals; Autoradiography; gamma-Aminobutyric Acid; Humans; Isonicotinic Acids; Isoxazoles; Oxazoles; Pipecolic Acids; Receptors, Cell Surface; Receptors, GABA-A; Tissue Distribution | 1981 |
Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure.
Topics: Agaricales; Amanita; Animals; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Structural; Molecular Conformation; Muscimol; Nipecotic Acids; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A; Stereoisomerism | 1981 |
Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist.
Topics: Analgesics; Animals; Brain; gamma-Aminobutyric Acid; Humans; Isoxazoles; Methylphenidate; Neurons; Oxazoles; Stereotyped Behavior; Synaptic Transmission | 1982 |
Acivicin. An antitumor antibiotic.
Topics: Animals; Antibiotics, Antineoplastic; Glycine; Humans; Isoxazoles; Neoplasms; Neoplasms, Experimental; Oxazoles | 1981 |
The treatment of rhinovirus infections: progress and potential.
Topics: 3C Viral Proteases; Antiviral Agents; Clinical Trials as Topic; Combined Modality Therapy; Common Cold; Cysteine Endopeptidases; Dietary Supplements; Drug Therapy, Combination; Echinacea; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; Intercellular Adhesion Molecule-1; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Phytotherapy; Picornaviridae Infections; Plant Extracts; Plants, Medicinal; Pyrrolidinones; Receptors, Virus; Rhinovirus; Valine; Viral Proteins; Zinc | 2001 |
Biotransformation reactions of five-membered aromatic heterocyclic rings.
Topics: Animals; Cytochrome P-450 Enzyme System; Furans; Heterocyclic Compounds, 4 or More Rings; Humans; Imidazoles; Indoles; Isoxazoles; Models, Chemical; Molecular Structure; Oxadiazoles; Oxazoles; Pyrazoles; Pyrroles; Tetrazoles; Thiadiazoles; Thiazoles; Thiophenes; Triazoles; Xenobiotics | 2002 |
RECENT DEVELOPMENTS IN ISOXAZOLE CHEMISTRY.
Topics: Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles | 1963 |
An integrated approach to developing chemoenzymatic processes at the industrial scale.
Topics: Bacillus; Biotechnology; Biotransformation; Catalysis; Chemistry, Pharmaceutical; Cost-Benefit Analysis; Drug Design; Enzymes; Fructose-Bisphosphate Aldolase; HIV Protease Inhibitors; Isoxazoles; Models, Chemical; Models, Theoretical; Oxazoles; Pharmaceutical Preparations; Phenylalanine; Pyrrolidines; Pyrrolidinones; Stereoisomerism; Valine | 2006 |
Michael acceptors as cysteine protease inhibitors.
Topics: Animals; Cysteine Proteinase Inhibitors; Drug Design; Humans; Isoxazoles; Leucine; Molecular Structure; Oxazoles; Peptides; Phenylalanine; Pyrrolidines; Pyrrolidinones; Structure-Activity Relationship; Sulfones; Valine | 2007 |
Chemical synthesis of heterocyclic-sugar nucleoside analogues.
Topics: Carbohydrates; Dioxolanes; Heterocyclic Compounds; Isoxazoles; Nucleosides; Oxazoles; Pyrrolidines; Sulfhydryl Compounds; Sulfides; Thiazolidines | 2010 |
25 trial(s) available for oxazoles and isoxazoles
| Article | Year |
|---|---|
Huntington's disease: treatment with muscimol, a GABA-mimetic drug.
Topics: Amanita; Betaine; Clinical Trials as Topic; Double-Blind Method; Humans; Huntington Disease; Isoxazoles; Oxazoles | 1977 |
[Clinical trial of a new non-steroidal anti-inflammatory analgesic, 31252-S, for postoperative pain following tooth extraction and minor ambulatory surgery].
Topics: Adolescent; Adult; Aged; Ambulatory Care; Anti-Inflammatory Agents, Non-Steroidal; Clinical Trials as Topic; Epirizole; Female; Humans; Isoxazoles; Male; Middle Aged; Minor Surgical Procedures; Mouth; Oxazoles; Pain, Postoperative; Periodontal Cyst; Piperidines; Placebos; Tooth Extraction | 1979 |
Broxaterol, a new beta 2-adrenoceptor agonist compared to salbutamol in asthmatics, oral and inhalation treatment.
Topics: Administration, Inhalation; Administration, Oral; Adrenergic beta-Agonists; Albuterol; Asthma; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic | 1989 |
Role of broxaterol in bronchial hyperresponsiveness.
Topics: Adrenergic beta-Agonists; Asthma; Bronchial Provocation Tests; Bronchial Spasm; Bronchodilator Agents; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic | 1989 |
Broxaterol: therapeutic trials and safety profile.
Topics: Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Child; Double-Blind Method; Humans; Isoxazoles; Oxazoles; Randomized Controlled Trials as Topic | 1989 |
Phase II trial of continuous drug infusions in advanced ovarian carcinoma: acivicin versus vinblastine.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Infusions, Intravenous; Isoxazoles; Middle Aged; Ovarian Neoplasms; Oxazoles | 1989 |
Broxaterol: a double-blind clinical trial comparing broxaterol and salbutamol.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Blood Pressure; Bronchitis; Clinical Trials as Topic; Double-Blind Method; Female; Forced Expiratory Volume; Heart Rate; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Pulse; Random Allocation; Spirometry; Time Factors | 1985 |
GABA-agonist therapy for Alzheimer's disease.
Topics: Alzheimer Disease; Clinical Trials as Topic; gamma-Aminobutyric Acid; Humans; Isoxazoles; Middle Aged; Neuropsychological Tests; Oxazoles; Somatostatin | 1986 |
Evaluation of a new bronchodilating compound (broxaterol) administered as a pressurized aerosol.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aged; Asthma; Bronchi; Bronchitis; Bronchospirometry; Double-Blind Method; Drug Evaluation; Forced Expiratory Volume; Humans; Isoxazoles; Maximal Midexpiratory Flow Rate; Middle Aged; Oxazoles; Random Allocation; Vital Capacity | 1987 |
Broxaterol (Z.1170), a new oral beta 2-agonist compared with salbutamol.
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Double-Blind Method; Female; Hemodynamics; Humans; Isoxazoles; Lung Diseases, Obstructive; Male; Middle Aged; Oxazoles; Random Allocation; Respiratory Function Tests | 1987 |
A comparison of the bronchodilator effects of broxaterol and salbutamol.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Adult; Aged; Albuterol; Asthma; Blood Pressure; Bronchodilator Agents; Female; Heart Rate; Humans; Isoxazoles; Lung Diseases, Obstructive; Male; Middle Aged; Oxazoles; Respiratory Function Tests; Time Factors | 1988 |
Early bronchodilating effect of a new oral beta-2-receptor agonist (broxaterol) in bronchial asthma.
Topics: Administration, Oral; Adrenergic beta-Agonists; Adult; Asthma; Bronchodilator Agents; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles | 1988 |
Pharmacologic effects of A-56234, a new high-ceiling diuretic.
Topics: Adolescent; Adult; Chlorides; Diuresis; Diuretics; Double-Blind Method; Humans; Isoxazoles; Male; Oxazoles; Sodium; Uricosuric Agents | 1988 |
Phase II evaluation of acivicin in lung cancer: a Southeastern Cancer Study Group Trial.
Topics: Antibiotics, Antineoplastic; Carcinoma, Bronchogenic; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Oxazoles | 1986 |
Phase II clinical trial of acivicin in advanced breast cancer: an Eastern Cooperative Oncology Group Study.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles | 1986 |
Phase II trial of acivicin in advanced breast carcinoma: a Cancer and Leukemia Group B Study.
Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Brain Diseases; Breast Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles | 1986 |
Pharmacokinetic and biochemical studies on acivicin in phase I clinical trials.
Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Clinical Trials as Topic; Drug Evaluation; Female; Humans; Isoxazoles; Kinetics; Liver Diseases; Male; Oxazoles | 1985 |
The effect of tetrahydroisoxazolopyridinol (THIP) in tardive dyskinesia: a new gamma-aminobutyric acid agonist.
Topics: Adult; Aged; Analgesics; Antipsychotic Agents; Blinking; Clinical Trials as Topic; Confusion; Dizziness; Dyskinesia, Drug-Induced; Female; Humans; Isoxazoles; Male; Mental Disorders; Middle Aged; Oxazoles; Parkinson Disease, Secondary; Placebos; Vomiting | 1982 |
THIP treatment of Huntington's disease.
Topics: Adult; Clinical Trials as Topic; Disability Evaluation; Double-Blind Method; Female; Homovanillic Acid; Humans; Huntington Disease; Isoxazoles; Male; Middle Aged; Oxazoles | 1983 |
Respiratory effect of THIP, a GABA-agonistic analgesic, during halothane anaesthesia.
Topics: Adolescent; Adult; Analgesics; Anesthesia, Inhalation; Clinical Trials as Topic; Halothane; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Respiration | 1983 |
Therapeutic effects of GABA-ergic drugs in affective disorders. A preliminary report.
Topics: Adolescent; Adult; Analgesics; Anticonvulsants; Bipolar Disorder; Carbamazepine; Clinical Trials as Topic; Diazepam; Double-Blind Method; Female; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Middle Aged; Mood Disorders; Oxazoles; Oxcarbazepine; Schizophrenia; Valproic Acid | 1983 |
THIP: a single-blind controlled trial in patients with epilepsy.
Topics: Adult; Anticonvulsants; Drug Evaluation; Epilepsy; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles | 1983 |
Analgesic from mushrooms begins clinical trials.
Topics: Analgesics; Clinical Trials as Topic; Humans; Isoxazoles; Oxazoles | 1981 |
Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers.
Topics: Adult; Antiviral Agents; Double-Blind Method; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Valine | 2002 |
Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers.
Topics: Administration, Inhalation; Adolescent; Adult; Antiviral Agents; Biological Availability; Common Cold; Double-Blind Method; Endpoint Determination; Female; Humans; Isoxazoles; Male; Middle Aged; Mucus; Oxazoles; Phenylalanine; Pyrrolidines; Pyrrolidinones; Rhinovirus; Suspensions; Valine | 2003 |
481 other study(ies) available for oxazoles and isoxazoles
| Article | Year |
|---|---|
GABA-mediated control of rat neostriatal tyrosine hydroxylase revealed by intranigral muscimol.
Topics: Aminobutyrates; Animals; Bicuculline; Caudate Nucleus; Corpus Striatum; Dopamine; Enzyme Activation; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Neural Pathways; Olfactory Bulb; Oxazoles; Pimozide; Pteridines; Quaternary Ammonium Compounds; Rats; Substantia Nigra; Tyrosine 3-Monooxygenase | 1976 |
Pharmacological properties of 2,3-dihydro-9H-isoxazolo [3,2-b] quinazolin-9-one (W-2429. Part 1: Analgesic, antipyretic and antiedema activity.
Topics: Administration, Oral; Analgesics, Opioid; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Aspirin; Body Temperature; Dextropropoxyphene; Drug Interactions; Drug Tolerance; Edema; Fever; Humans; Injections, Intravenous; Isoxazoles; Lethal Dose 50; Male; Mice; Narcotic Antagonists; Oxazoles; Quinazolines; Rats; Substance-Related Disorders; Time Factors | 1977 |
GABA-like properties of flurazepam and baclofen suggested by rotational behaviour following unilateral intranigral injection: a comparison with the GABA agonist muscimol [proceedings].
Topics: Aminobutyrates; Animals; Anti-Anxiety Agents; Baclofen; Behavior; Flurazepam; gamma-Aminobutyric Acid; Humans; Injections; Isoxazoles; Male; Oxazoles; Rats; Stereotyped Behavior; Substantia Nigra | 1977 |
5-Carboxamido-4-amino-3-isoxazolidone, and asparagine analogue.
Topics: Animals; Antineoplastic Agents; Aspartate-Ammonia Ligase; Carcinoma, Hepatocellular; Isoxazoles; Leukemia L1210; Leukemia, Experimental; Liver Neoplasms; Mice; Neoplasms, Experimental; Oxazoles; Oxazolidinones | 1978 |
Proceedings: The presence of isoxazolin-5-one derivatives in root exudates of pea and sweet pea seedlings.
Topics: Isoxazoles; Oxazoles; Plant Development; Plant Physiological Phenomena | 1976 |
Oxonol dyes as monitors of membrane potential. Their behavior in photosynthetic bacteria.
Topics: Antimycin A; Bacterial Chromatophores; Carotenoids; Chromatium; Fluorescent Dyes; Isoxazoles; Kinetics; Light; Membrane Potentials; Oxazoles; Photosynthesis; Rhodobacter sphaeroides; Rhodospirillum rubrum; Spectrophotometry; Structure-Activity Relationship | 1979 |
The disposition of 3-methyl-2,3-dihydro-9H-isoxazolo[3,2-b]-quinazolin-9-one (W-2451).
Topics: Analgesics; Animals; Biotransformation; Blood Proteins; Dogs; Haplorhini; Humans; In Vitro Techniques; Isoxazoles; Liver; Male; Oxazoles; Quinazolines; Rats; Species Specificity; Time Factors; Tissue Distribution | 1979 |
Relationships between plasma concentrations of diphenylhydantoin, phenobarbital, carbamazepine, and 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810), a new anticonvulsant agent, and their anticonvulsant or neurotoxic effects in experimental animals.
Topics: Animals; Anticonvulsants; Brain; Carbamazepine; Dogs; Dose-Response Relationship, Drug; Haplorhini; Isoxazoles; Male; Mice; Motor Skills; Oxazoles; Phenobarbital; Phenytoin; Rabbits; Rats; Seizures; Species Specificity | 1979 |
Urinary metabolites of 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole in the dog.
Topics: Animals; Antiprotozoal Agents; Biotransformation; Chagas Disease; Chromatography, Gas; Dogs; Female; Isoxazoles; Mass Spectrometry; Mice; Nitroimidazoles; Oxazoles; Salmonella | 1979 |
A new class of GABA agonist.
Topics: Action Potentials; Aminobutyrates; Animals; Bicuculline; Biological Transport; Cats; gamma-Aminobutyric Acid; Interneurons; Isonicotinic Acids; Isoxazoles; Molecular Conformation; Neural Inhibition; Oxazoles; Receptors, Neurotransmitter; Spinal Cord; Structure-Activity Relationship; Synaptic Transmission | 1977 |
Mechanisms by which diazepam, muscimol, and other drugs change the content of cGMP in cerebellar cortex.
Topics: Alkaloids; Animals; Cerebellar Cortex; Cyclic GMP; Diazepam; Haloperidol; Harmaline; Isoxazoles; Male; Morphine; Oxazoles; Purkinje Cells; Pyridines; Rats | 1977 |
Muscimol binding in rat brain: association with synaptic GABA receptors.
Topics: Aminobutyrates; Animals; Binding Sites; Brain; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Polyethylene Glycols; Rats; Receptors, Neurotransmitter; Sodium | 1978 |
Use of 3H-muscimol for GABA receptor studies.
Topics: Aminobutyrates; Animals; Bicuculline; Binding, Competitive; Brain; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Oxazoles; Potassium; Rats; Receptors, Neurotransmitter; Stereoisomerism; Synaptosomes | 1978 |
GABA agonists and potential antagonists related to muscimol.
Topics: Animals; Dose-Response Relationship, Drug; Functional Laterality; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Receptors, Neurotransmitter; Stereotyped Behavior; Substantia Nigra | 1979 |
Kinetics of the potential-sensitive extrinsic probe oxonol VI in beef heart submitochondrial particles.
Topics: Adenosine Triphosphate; Animals; Calibration; Cattle; Cell Membrane Permeability; Fluorescent Dyes; Intracellular Membranes; Isoxazoles; Kinetics; Mitochondria, Heart; NAD; Oxazoles; Oxygen; Spectrum Analysis; Valinomycin | 1979 |
The behavior of oxonol dyes in phospholipid dispersions.
Topics: Alkenes; Cholesterol; Fluorescent Dyes; Isoxazoles; Kinetics; Lipid Bilayers; Oxazoles; Phospholipids; Pulmonary Surfactants; Sonication; Spectrophotometry | 1979 |
Absorption, distribution and metabolic fate of 2,3-dihydro-9H-isoxazolo-[3,2-b]quinazolin-9-one (W2429).
Topics: Administration, Oral; Adult; Animals; Anti-Inflammatory Agents, Non-Steroidal; Biotransformation; Blood Proteins; Dogs; Humans; Intestinal Absorption; Isoxazoles; Kinetics; Male; Mice; Oxazoles; Protein Binding; Quinazolines; Rats | 1977 |
Toxicological investigation of 2,3-dihydro-9H-isoxazolo[3,2-b]quinazolin-9-one (W-2429). Acute and subacute toxicity in mice, rats and dogs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Blood Cell Count; Blood Chemical Analysis; Body Weight; Dogs; Female; Isoxazoles; Lethal Dose 50; Male; Mice; Organ Size; Oxazoles; Quinazolines; Rats; Spermatogenesis; Time Factors | 1977 |
Absorption, excretion, distribution and metabolism of perisoxal in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Intestinal Absorption; Isoxazoles; Male; Oxazoles; Rats; Tissue Distribution | 1979 |
Studies in potential organo-fluorine antibacterial agents. Part 2: Synthesis and antibacterial activity of some new fluorine-containing 3.5-disubstituted isoxazoles.
Topics: Anti-Bacterial Agents; Escherichia coli; Isoxazoles; Oxazoles; Staphylococcus; Streptococcus | 1979 |
Studies in potential organo-fluorine antibacterial agents. Part 3: Synthesis and antibacterial activity of some new fluorine containing 2,4,5-trisubstituted isoxazoles.
Topics: Anti-Bacterial Agents; Bacteria; Escherichia coli; Fluorine; Isoxazoles; Oxazoles; Staphylococcus; Structure-Activity Relationship | 1979 |
Pharmacological properties of 2,3-dihydro-9H-isoxazolo[3,2-b]-quinazolin-9-one (W-2429. Part 2: General pharmacological investigation.
Topics: Anesthetics, Local; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anticonvulsants; Antidepressive Agents, Tricyclic; Antitussive Agents; Cats; Diuresis; Dogs; Enzyme Induction; Female; Gastrointestinal Hemorrhage; Gastrointestinal Motility; Guinea Pigs; Hemodynamics; Isoxazoles; Male; Mice; Motor Activity; Muscle Contraction; Muscle, Smooth; Oxazoles; Postural Balance; Prostaglandin-Endoperoxide Synthases; Quinazolines; Rabbits; Rats; Respiration; Sleep; Stomach Ulcer; Time Factors | 1977 |
Effects of antiprogesterone on pregnancy. I. Midpregnancy.
Topics: Administration, Oral; Animals; Drug Evaluation, Preclinical; Estradiol; Female; Fetal Death; Fetus; Isoxazoles; Oxazoles; Pregnancy; Pregnancy Trimester, Third; Pregnancy, Animal; Progesterone; Prostaglandins F; Radioimmunoassay; Rats; Uterus | 1979 |
Biochemical and pharmacological effects of the fermentation-derived antitumor agent, (alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
Topics: 3-Deazauridine; Animals; Antibiotics, Antineoplastic; Drug Resistance; Female; Glycine; Isoxazoles; Lethal Dose 50; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Nucleotides; Oxazoles; Sex Factors | 1979 |
Therapy for mouse tumors and human tumor xenografts with the antitumor antibiotic AT-125.
Topics: Animals; Antibiotics, Antineoplastic; Disease Models, Animal; Drug Evaluation, Preclinical; Female; Glycine; Humans; Isoxazoles; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Oxazoles; Transplantation, Heterologous | 1979 |
Charge transfer during Ca2+ uptake by rabbit skeletal muscle sarcoplasmic reticulum vesicles as measured with oxanol VI.
Topics: Animals; Calcium; Cell-Free System; Coloring Agents; Female; Isoxazoles; Membrane Potentials; Oxazoles; Rabbits; Sarcoplasmic Reticulum | 1979 |
Induction of preterm labor in the rat by antiprogesterone.
Topics: Administration, Oral; Animals; Estradiol; Female; Injections, Intramuscular; Isoxazoles; Labor, Induced; Oxazoles; Pregnancy; Progesterone; Progesterone Congeners; Prostaglandins F; Rats; Uterus | 1979 |
Enhanced effect of an L-glutamine antagonist, L-(alphaS,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, by Acinetobacter L-glutaminase-L-asparaginase.
Topics: Acinetobacter; Amino Acids; Animals; Asparaginase; Carcinoma, Ehrlich Tumor; Drug Synergism; Drug Therapy, Combination; Female; Glutaminase; Glutamine; Glycine; Isoxazoles; Lethal Dose 50; Leukemia L1210; Male; Mice; Oxazoles | 1979 |
Pharmacokinetic and pharmacodynamic tolerance of a new anticonvulsant agent (3-sulfamoylmethyl-1,2-benzisoxazole) compared to phenobarbital, diphenylhydantoin and carbamazepine in rats.
Topics: Animals; Anticonvulsants; Carbamazepine; Drug Interactions; Hexobarbital; Isoxazoles; Kinetics; Male; Oxazoles; Phenobarbital; Phenytoin; Proadifen; Rats; Sleep; Time Factors | 1979 |
THIP and isoguvacine are partial agonists of GABA-stimulated benzodiazepine receptor binding.
Topics: Animals; Benzodiazepines; Cerebral Cortex; Drug Synergism; Flunitrazepam; gamma-Aminobutyric Acid; In Vitro Techniques; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Drug | 1979 |
Conformational analysis of muscimol, a GABA agonist.
Topics: Bicuculline; Binding Sites; gamma-Aminobutyric Acid; Isoxazoles; Models, Molecular; Molecular Conformation; Muscimol; Oxazoles; Quantum Theory | 1979 |
[Central effect of new benzoxazoline-2 and 3-hydroxybenzisoxazole derivatives].
Topics: Animals; Benzoxazoles; Body Temperature; Chemical Phenomena; Chemistry; Female; Isoxazoles; Male; Mice; Motor Activity; Nociceptors; Oxazoles; Sleep | 1979 |
Potential antiinflammatory compounds. 2. Acidic antiinflammatory 1,2-benzisoxazoles.
Topics: Animals; Anti-Inflammatory Agents; Carrageenan; Edema; Isoxazoles; Oxazoles; Rats; Structure-Activity Relationship | 1979 |
New CNS-active 3-methyl-4-substituted methyl-delta 2-isoxazolin-5-ones.
Topics: Animals; Anticonvulsants; Central Nervous System Depressants; Female; Isoxazoles; Male; Mice; Monoamine Oxidase Inhibitors; Oxazoles; Pentobarbital; Rats; Sleep; Time Factors | 1979 |
Does uptake limit the actions of GABA agonists in vivo? Experiments with muscimol, isoguvacine and THIP in cat spinal cord.
Topics: Aminobutyrates; Animals; Biological Transport; Cats; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Muscimol; Neurons; Nipecotic Acids; Oxazoles; Spinal Cord | 1978 |
Rotational behaviour after unilateral intranigral injection of muscimol in rats.
Topics: Aminobutyrates; Animals; Basidiomycota; Behavior; Bicuculline; gamma-Aminobutyric Acid; Humans; Injections; Isoxazoles; Male; Oxazoles; Picrotoxin; Rats; Stereotyped Behavior; Substantia Nigra; Time Factors | 1977 |
Muscimol a GABA-agonist injected into the nucleus accumbens increases apomorphine stereotypy and decreases the motility.
Topics: Aminobutyrates; Animals; Apomorphine; Basidiomycota; Behavior; GABA Antagonists; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Motor Activity; Nucleus Accumbens; Oxazoles; Rats; Septal Nuclei; Stereotyped Behavior | 1977 |
The action of muscimol on neurones of the substantia nigra of the rat.
Topics: Animals; Basidiomycota; Corpus Striatum; Electric Stimulation; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Male; Neural Inhibition; Neurons; Oxazoles; Rats; Substantia Nigra | 1978 |
Muscimol differentially facilitates stereotypy but antagonizes motility induced by dopaminergic drugs: a complex GABA-dopamine interaction.
Topics: Animals; Apomorphine; Basidiomycota; Behavior; Cocaine; Dopamine; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Isoxazoles; Male; Methylphenidate; Methyltyrosines; Mice; Motor Activity; Oxazoles; Stereotyped Behavior | 1978 |
Effect of muscimol on single unit activity of substantia nigra dopamine neurons.
Topics: Anesthesia; Animals; Basidiomycota; Dopamine; Isoxazoles; Male; Neurons; Oxazoles; Rats; Substantia Nigra; Time Factors | 1978 |
Muscimol, GABA and picrotoxin: effects on membrane conductance of a crustacean neuron.
Topics: Aminobutyrates; Animals; Astacoidea; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Mechanoreceptors; Membrane Potentials; Mycotoxins; Neural Inhibition; Neurons; Oxazoles; Picrotoxin; Receptors, Drug; Synaptic Membranes | 1978 |
GABA receptor binding with 3H-muscimol in calf cerebellum.
Topics: Aminobutyrates; Animals; Bicuculline; Cattle; Cerebellum; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Kinetics; Oxazoles; Receptors, Drug | 1978 |
Determination of 1,2-benzisoxazole-3-acetamidoxime hydrochloride (PE-257) in plasma using electron-capture gas chromatography.
Topics: Animals; Chromatography, Gas; Isoxazoles; Oxazoles; Oximes; Psychotropic Drugs; Rats | 1978 |
Muscimol antagonizes morphine hypermotility without potentiation of analgesia.
Topics: Analgesia; Analgesics; Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Motor Activity; Neuromuscular Blocking Agents; Oxazoles | 1978 |
Effects of multiple treatments of isoxicam on organ weights and serum SGPT, AP, and BUN in adjuvant-induced polyarthritic rats.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Arthritis; Arthritis, Experimental; Blood Urea Nitrogen; Isoxazoles; Male; Organ Size; Oxazoles; Piroxicam; Rats; Thiazines | 1978 |
Nipecotic acid and 2,4-diaminobutyric acid enhance the actions of muscimol on cerebral cortical neurons.
Topics: Action Potentials; Amino Acids, Diamino; Aminobutyrates; Animals; Cerebral Cortex; Drug Synergism; Female; gamma-Aminobutyric Acid; Isoxazoles; Mycotoxins; Neurons; Nipecotic Acids; Oxazoles; Rats | 1978 |
Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds.
Topics: Aminobutyrates; Animals; Brain; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Structure-Activity Relationship; Synaptic Membranes | 1978 |
Studies of the biochemical pharmacology of the fermentation-derived antitumor agent, (alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
Topics: Animals; Antibiotics, Antineoplastic; Cell Division; Cell Line; Cell Survival; Female; Glutamine; Glycine; Isoxazoles; Leukemia L1210; Leukemia P388; Macromolecular Substances; Male; Mice; Oxazoles; Sex Factors; Thymidine; Uridine; Valine | 1978 |
Inactivation of Bacillus cereus beta-lactamase by halogenated isoxazolylpenicillins.
Topics: Bacillus cereus; beta-Lactamase Inhibitors; Dicloxacillin; Isoxazoles; Kinetics; Mathematics; Oxazoles; Penicillins; Structure-Activity Relationship; Temperature; Time Factors | 1976 |
Novel pyrazolo, isoxazolo, and thiazolo steroidal systems and model analogs containing dimethyoxylaryl (or dihydroxylaryl) groups and derivatives. Synthesis, spectral properties, and biological activity.
Topics: Bacillus subtilis; Cells, Cultured; Depression, Chemical; Humans; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pseudomonas fluorescens; Pyrazoles; Spectrophotometry, Infrared; Staphylococcus aureus; Steroids, Heterocyclic; Thiazoles | 1976 |
Synthesis and structure-activity relationships of heterocyclic compounds containing a trimethoxyarene function.
Topics: Bacillus subtilis; Cells, Cultured; Depression, Chemical; Humans; Isoxazoles; Methyl Ethers; Microbial Sensitivity Tests; Naphthalenes; Oxazoles; Phenanthrenes; Pseudomonas fluorescens; Pyrazoles; Structure-Activity Relationship | 1976 |
Association of halogenated isoxazolylpenicillins with penicillinase-sensitive beta-lactam antibiotics. Microbiological evaluation on beta-lactamase-producing Enterobacteriaceae.
Topics: Animals; Anti-Bacterial Agents; beta-Lactams; Enterobacteriaceae; Halogens; Isoxazoles; Mice; Microbial Sensitivity Tests; Oxazoles; Penicillinase; Penicillins | 1977 |
Potentiation of morphine analgesia by muscimol.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Synergism; Isoxazoles; Mice; Morphine; Oxazoles; Quaternary Ammonium Compounds; Rats | 1977 |
Muscimol antagonizes the ergometrine-induced locomotor activity in nucleus accumbens: evidence for a GABA--dopaminergic interaction.
Topics: Aminobutyrates; Animals; Dopamine; Ergonovine; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Olfactory Bulb; Oxazoles; Rats; Time Factors | 1977 |
Polarographic study of new antibacterial isoxazolium salts: 2,3-dialkyl-5-arylisoxazolium perchlorates.
Topics: Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Oxidation-Reduction; Polarography; Staphylococcus aureus; Structure-Activity Relationship | 1977 |
Isoxazole anthelmintics.
Topics: Animals; Anthelmintics; Hookworm Infections; Isoxazoles; Nippostrongylus; Oxazoles; Rats; Structure-Activity Relationship | 1977 |
3-hydroxyisoxazole-5-hydroxamic acid.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents; Antineoplastic Agents; Bacteria; Fungi; Hydroxamic Acids; Isoxazoles; Leukemia L1210; Leukemia, Experimental; Mice; Microbial Sensitivity Tests; Oxazoles | 1977 |
Effect of muscimol, a GABA-mimetic agent, on dopamine metabolism in the mouse brain.
Topics: 3,4-Dihydroxyphenylacetic Acid; Adenylyl Cyclases; Aminobutyrates; Animals; Brain; Caudate Nucleus; Diazepam; Dopamine; Dose-Response Relationship, Drug; Drug Synergism; gamma-Aminobutyric Acid; Homovanillic Acid; Isoxazoles; Male; Mice; Motor Activity; Oxazoles; Phenobarbital | 1977 |
[Nitrones, VIII. Isoxazolidine-compounds, VII: Reformatzky reaction with ketonitrones. Slow N-inversion in the 5-isoxazolidinone ring (author's transl)].
Topics: Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Nitrogen Oxides; Oxazoles; Time Factors | 1977 |
3-Isoxazolidone--an inhibitor of GABA metabolism.
Topics: Aminobutyrates; Animals; Brain; Chickens; Depression, Chemical; GABA Antagonists; gamma-Aminobutyric Acid; Glutamate Decarboxylase; In Vitro Techniques; Isoniazid; Isoxazoles; Male; Mice; Oxazoles; Oxazolidinones; Rats; Seizures; Time Factors | 1976 |
Preparation of tri- and tetramethyleneisoxazoles.
Topics: Cyclization; Isoxazoles; Oxazoles | 1976 |
The in vitro metabolism of 3-(1-hydroxy-2-piperidinoethyl)-5-phenyl-isoxazole citrate (31252-S) with rabbit liver homogenate.
Topics: Animals; In Vitro Techniques; Isoxazoles; Kinetics; Liver; Male; Mice; Oxazoles; Piperidines; Rabbits | 1976 |
Synthesis, structure determination, spectral properties, and energy-linked spectral responses of the extrinsic probe oxonol V in membranes.
Topics: Animals; Binding Sites; Cell Membrane; Columbidae; Energy Transfer; Isoxazoles; Magnetic Resonance Spectroscopy; Membranes; Membranes, Artificial; Mitochondria, Muscle; Molecular Conformation; Myocardium; Oxazoles; Potassium; Spectrometry, Fluorescence; Spectrophotometry | 1976 |
Regional changes in the rate of turnover of acetylcholine in rat brain following diazepam or muscimol.
Topics: Acetylcholine; Animals; Brain; Cerebral Cortex; Corpus Striatum; Diazepam; gamma-Aminobutyric Acid; Hippocampus; Isoxazoles; Male; Oxazoles; Quaternary Ammonium Compounds; Rats; Receptors, Drug | 1976 |
Anti-inflammatory activity of isoxicam in combination with aspirin or D-propoxyphene.
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Aspirin; Body Weight; Dextropropoxyphene; Drug Therapy, Combination; Isoxazoles; Male; Organ Size; Oxazoles; Piroxicam; Rats; Thiazines | 1976 |
[Nitrones. 6. Isoxazolidine compounds. 6. Malonic ester addition of nitrones with large N-substituents].
Topics: Chemical Phenomena; Chemistry; Isoxazoles; Malonates; Nitrogen Oxides; Oxazoles | 1976 |
[Condensation of 2,3-dimethyl-4-carbetoxyisoxazoline-5-one with aromatic aldehydes].
Topics: Aldehydes; Isoxazoles; Oxazoles; Spectrophotometry, Ultraviolet | 1976 |
Effects of 1,2-benzisoxazole-3-acetamidoxime on central monoamine neurons in the rat.
Topics: Animals; Biogenic Amines; Brain; Brain Chemistry; Isoxazoles; Levodopa; Male; Neurons; Oxazoles; Oximes; Psychotropic Drugs; Rats | 1976 |
[Nitrones. 7. Synthesis of an isoxazoline by dimerization of a C-methylnitrone].
Topics: Chemical Phenomena; Chemistry; Isoxazoles; Nitrogen Oxides; Oxazoles | 1976 |
Effect of 1,2-benzisoxazole-3-acetamidoxime on caudato-thalamo-cortical system in cats.
Topics: Animals; Cats; Caudate Nucleus; Cerebral Cortex; Electroencephalography; Female; Isoxazoles; Male; Oxazoles; Oximes; Seizures; Thalamus | 1976 |
Absorption, distribution, and metabolic fate of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one in rats, dogs, and humans.
Topics: Animals; Anti-Inflammatory Agents; Dogs; Drug Stability; Humans; In Vitro Techniques; Intestinal Absorption; Isoxazoles; Male; Oxazines; Oxazoles; Protein Binding; Radioisotope Dilution Technique; Rats; Salicylates; Time Factors | 1975 |
Treatment of endometriosis with Danazol.
Topics: Adult; Castration; Endometriosis; Ethisterone; Fallopian Tubes; Female; Humans; Hysterectomy; Isoxazoles; Neoplasm Metastasis; Neoplasm Recurrence, Local; Ovarian Neoplasms; Oxazoles; Uterine Neoplasms | 1975 |
[Structure-activity relationship in histamine analogs. 10. 3-(2-aminoethyl)isoxazole, a ring analog of histamine].
Topics: Ethylamines; Histamine; Isoxazoles; Oxazoles; Structure-Activity Relationship | 1975 |
The isolation, structure, and absolute configuration of U-43,795, a new antitumor agent.
Topics: Amino Acids; Antimetabolites, Antineoplastic; Chemical Phenomena; Chemistry; Glycine; Isoxazoles; Molecular Conformation; Molecular Weight; Oxazoles; Streptomyces | 1975 |
C-glycosyl nucleosides. VI. Synthesis of several 3- and 5-(beta-D-ribofuranosyl)isoxazoles.
Topics: Isoxazoles; Methods; Oxazoles; Ribonucleosides; Temperature | 1975 |
Comparative anti-inflammatory, analgesic, and antipyretic activities of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo-(3,2-b)(1,3)-benzoxazin-9-one and 5-chlorosalicylic acid in rats.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Arthritis; Body Temperature; Edema; Isoxazoles; Male; Oxazines; Oxazoles; Rats; Salicylates; Stomach Ulcer | 1975 |
Improved methods for production, isolation, and assay of two new chlorisoxazoline amino acid antitumor antimetabolites: U-42, 126 and U43, 795.
Topics: Antibiotics, Antineoplastic; Antimetabolites; Glycine; Isoxazoles; Methods; Oxazoles | 1975 |
Induced adrenal and ovarian enlargement in nursing mothers by a single mug injection to their pups of a 3beta-hydroxy-delta5-steroid oxidoreductase inhibitor.
Topics: Adrenal Glands; Animals; Animals, Newborn; Female; Hydroxysteroid Dehydrogenases; Isoxazoles; Lactation; Ovary; Oxazoles; Pituitary Gland; Pregnancy; Progesterone Reductase; Rats | 1975 |
[Isoxazolo(5.4-b)pyridines (author's transl)].
Topics: Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pyridines; Spectrophotometry, Infrared | 1975 |
[Isoxazoles substituted with 4-pyridyl and o-chlorophenyl radicals].
Topics: Animals; Anticonvulsants; Chlorobenzenes; Drug Evaluation, Preclinical; Isoxazoles; Male; Muscles; Oxazoles; Pyridines; Rats | 1975 |
[New isoxazol /5,4-b/ pyridine-3-acetic acids].
Topics: Acetates; Anti-Inflammatory Agents; Isoxazoles; Oxazoles; Plant Growth Regulators; Pyridines | 1975 |
Inhibition of GABA uptake in rat brain slices by nipecotic acid, various isoxazoles and related compounds.
Topics: Aminobutyrates; Animals; Biological Transport, Active; Brain; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Kinetics; Nipecotic Acids; Oxazoles; Rats; Structure-Activity Relationship | 1975 |
The anti=inflammatory properties of isoxicam (4-hydroxy-2methyl-N-(5-methyl-3isoxolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxide).
Topics: Animals; Anti-Inflammatory Agents; Arthritis, Experimental; Carrageenan; Inflammation; Isoxazoles; Male; Oxazoles; Peptic Ulcer; Piroxicam; Rats; Thiazines | 1975 |
[Synthesis of naphthisoxazole derivatives. I. Synthesis of 4,5-dihydronaphth(2,1-d)isoxazole derivatives (author's transl)].
Topics: Isoxazoles; Naphthalenes; Oxazoles | 1975 |
[Oxidant-drug induced hemolytic anemia in dogs].
Topics: Aminopyrine; Anemia, Hemolytic; Animals; Bilirubin; Blood Cell Count; Blood Proteins; Dogs; Female; Glucosephosphate Dehydrogenase; Glutathione; Isoxazoles; Liver; Male; Methemoglobinemia; Osmotic Fragility; Oxazoles; Phenacetin; Phenylhydrazines; Piperidines; Spleen | 1975 |
NMR determination of enantiomers of 7-chloro-3,3a-dihydro-2-methyl-2H,9H-isoxazolo(3,2-b)(1,3)benzoxazin-9-one using chiral shift reagent, tris(3-(heptafluorobutyryl)-d-camphorato)europium(III).
Topics: Europium; Isoxazoles; Magnetic Resonance Spectroscopy; Methods; Oxazines; Oxazoles | 1976 |
Two mechanisms by which fluorescent oxonols indicate membrane potential in human red blood cells.
Topics: Benzenesulfonates; Erythrocyte Membrane; Erythrocytes; Fluorescent Dyes; Gramicidin; Hematocrit; Humans; Isoxazoles; Kinetics; Membrane Potentials; Models, Biological; Oxazoles; Potassium Chloride; Spectrometry, Fluorescence; Structure-Activity Relationship; Valinomycin | 1990 |
The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of gamma-glutamyl transpeptidase inhibition.
Topics: Animals; Catheterization; gamma-Glutamyltransferase; Glutathione; Hydroquinones; Isoxazoles; Kidney; Male; Oxazoles; Rats; Rats, Inbred Strains | 1990 |
Competitive binding enzyme immunoassay for zonisamide, a new antiepileptic drug, with selected paired-enzyme labeled antigen and antibody.
Topics: Antibodies; Anticoagulants; Anticonvulsants; Antigens; beta-Galactosidase; Binding, Competitive; Chromatography, High Pressure Liquid; Cross Reactions; Galactosidases; Humans; Immune Sera; Immunoenzyme Techniques; Isoxazoles; Milk, Human; Oxazoles; Zonisamide | 1990 |
Prolonged survival by tumor-bearing rats treated with acivicin and total parenteral nutrition.
Topics: Animals; Antimetabolites, Antineoplastic; Combined Modality Therapy; Isoxazoles; Male; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Survival Rate | 1990 |
[Pharmacological profile of mofezolac, a new non-steroidal analgesic anti-inflammatory drug].
Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Body Weight; Capillary Permeability; Cyclooxygenase Inhibitors; Edema; Gastric Mucosa; Isoxazoles; Mice; Organ Size; Oxazoles; Platelet Aggregation Inhibitors; Rabbits; Rats | 1990 |
Zonisamide-induced mania.
Topics: Adult; Anticonvulsants; Bipolar Disorder; Dose-Response Relationship, Drug; Epilepsy, Post-Traumatic; Epilepsy, Temporal Lobe; Humans; Isoxazoles; Male; Oxazoles; Psychoses, Substance-Induced; Zonisamide | 1990 |
4-Isoxazolyl-1,4-dihydropyridines: biological, theoretical, and structural studies.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cell Membrane; Chemical Phenomena; Chemistry, Physical; Crystallization; Dihydropyridines; Guinea Pigs; Ileum; Isoxazoles; Isradipine; Molecular Conformation; Molecular Structure; Myocardium; Oxadiazoles; Oxazoles; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
Modulation of tolerance to the GABAA agonist THIP by environmental cues.
Topics: Animals; Anticonvulsants; Arousal; Association Learning; Brain; Conditioning, Classical; Dose-Response Relationship, Drug; Drug Tolerance; Exploratory Behavior; Isoxazoles; Male; Mice; Mice, Inbred Strains; Motor Activity; Oxazoles; Receptors, GABA-A; Social Environment | 1990 |
A model for compounds active against human rhinovirus-14 based on X-ray crystallography data.
Topics: Antiviral Agents; Binding Sites; Capsid; Isoxazoles; Microbial Sensitivity Tests; Models, Molecular; Oxazoles; Rhinovirus; Structure-Activity Relationship; X-Ray Diffraction | 1990 |
Disoxaril stabilization and immunogenicity of poliovirus procapsids.
Topics: Animals; Antibodies, Viral; Antigens, Viral; Capsid; HeLa Cells; Humans; Hydrogen-Ion Concentration; Immunization; Isoxazoles; Mice; Mice, Inbred BALB C; Neutralization Tests; Oxazoles; Poliovirus; Protein Denaturation; Temperature; Virion | 1990 |
Use of oxonol V as a probe of membrane potential in proteoliposomes containing cytochrome oxidase in the submitochondrial orientation.
Topics: Calibration; Cell Membrane; Cytochrome c Group; Electron Transport Complex IV; Isoxazoles; Lipid Bilayers; Liposomes; Membrane Potentials; Mitochondria; Oxazoles; Proteolipids; Spectrometry, Fluorescence | 1990 |
Effects of inhibitors of protein synthesis and intracellular transport on the gamma-aminobutyric acid agonist-induced functional differentiation of cultured cerebellar granule cells.
Topics: Animals; Anticonvulsants; Cell Differentiation; Cell Membrane; Cells, Cultured; Cerebellum; Colchicine; Cycloheximide; Dactinomycin; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Monensin; Oxazoles; Protein Synthesis Inhibitors; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1990 |
Effects of isoxazolyl-naphthoquinoneimines on growth and oxygen radical production in Trypanosoma cruzi and Crithidia fasciculata.
Topics: Animals; Antiprotozoal Agents; Crithidia; DNA; Free Radicals; Hydrogen Peroxide; Imines; Intracellular Membranes; Isoxazoles; Microsomes; Mitochondria; Naphthoquinones; Oxazoles; Oxygen; Trypanosoma cruzi | 1990 |
Studies on antifungal agents. Novel cis-5-alkyl (or alkenyl)-3-phenyl-3-(1H-azol-1-ylmethyl)-2-methyl-isoxazolidine derivatives.
Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Isoxazoles; Microbial Sensitivity Tests; Oxazoles | 1990 |
Mechanism of uricosuric action of AA-193 in DBA/2N mice.
Topics: Animals; Inulin; Isoxazoles; Kidney Tubules, Proximal; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Oxazoles; Pyrazinamide; Species Specificity; Uric Acid; Uricosuric Agents | 1990 |
Studies on antifungal agents. In vitro activity of novel cis-5-alkoxy (or acyloxy)alkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine derivatives.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Oxazoles | 1990 |
Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia.
Topics: Animals; Azaserine; Azo Compounds; Carbon-Nitrogen Ligases; Cell Line; Chromatography, High Pressure Liquid; Diazooxonorleucine; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Isoxazoles; Leukemia L1210; Ligases; Mice; Nucleotides; Oxazoles; Spectrophotometry, Ultraviolet | 1990 |
Anticonvulsant effects of zonisamide and phenytoin on seizure activity of the feline visual cortex.
Topics: Animals; Anticonvulsants; Cats; Dose-Response Relationship, Drug; Epilepsy; Female; Isoxazoles; Kindling, Neurologic; Male; Oxazoles; Phenytoin; Visual Cortex; Zonisamide | 1990 |
Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis.
Topics: Animals; Antiprotozoal Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cells, Cultured; Enzyme Activation; Isoxazoles; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Oxazoles | 1990 |
Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture.
Topics: Amino Acids; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cats; Central Nervous System; Electrolytes; Female; Glucose; Humans; Infusions, Intravenous; Isoxazoles; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Mice, Nude; Oxazoles; Parenteral Nutrition Solutions; Reference Values; Solutions; Transplantation, Heterologous | 1990 |
Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Oxazoles; Phosphoribosyl Pyrophosphate; Phosphotransferases | 1985 |
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801. Relation to cAMP concentration and Ca2+ uptake.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Bucladesine; Calcium; Colforsin; Cyclic AMP; Diterpenes; Hypoglycemic Agents; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Nifedipine; Oxazoles; Rats; Rats, Inbred Strains; Theophylline; Tolbutamide; Verapamil | 1985 |
Lymphocyte membrane potential and Ca2+-sensitive potassium channels described by oxonol dye fluorescence measurements.
Topics: 4-Aminopyridine; Aminopyridines; Animals; Calcimycin; Calcium; Cell Membrane Permeability; Electrodes; Flow Cytometry; Fluorescent Dyes; Humans; Ion Channels; Isoxazoles; Lymphocytes; Mathematics; Membrane Potentials; Mice; Oxazoles; Potassium; Quinine; Trifluoperazine | 1985 |
Enzyme targets of antiglutamine agents in cancer chemotherapy.
Topics: Animals; Anthranilate Synthase; Antibiotics, Antineoplastic; Azaserine; Drug Synergism; Glutamine; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nitrogenous Group Transferases; Oxazoles; Phosphoribosyl Pyrophosphate; Rats; Ribonucleotides; Transferases | 1985 |
[Effect of Woodward's reagent K on tetrodotoxin-sensitive sodium channels of spinal ganglion neurons of the rat].
Topics: Animals; Ganglia, Spinal; In Vitro Techniques; Ion Channels; Isoxazoles; Neurons, Afferent; Oxazoles; Ranvier's Nodes; Rats; Sodium; Tetrodotoxin | 1986 |
Zonisamide enhances slow sodium inactivation in Myxicola.
Topics: Animals; Anticonvulsants; Axons; Ion Channels; Isoxazoles; Membrane Potentials; Oxazoles; Polychaeta; Potassium; Sodium; Zonisamide | 1987 |
Oxonol VI as an optical indicator for membrane potentials in lipid vesicles.
Topics: Adsorption; Diffusion; Fluorescence; Fluorescent Dyes; Indicators and Reagents; Ion Channels; Isoxazoles; Liposomes; Membrane Potentials; Oxazoles; Phosphatidylcholines; Potassium; Sodium; Sodium-Potassium-Exchanging ATPase; Solutions; Spectrometry, Fluorescence; Spectrophotometry; Valinomycin | 1987 |
Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.
Topics: Amphetamine; Animals; Antipsychotic Agents; Apomorphine; Conditioning, Psychological; Dogs; Dopamine Antagonists; Dose-Response Relationship, Drug; Female; Haloperidol; Isoxazoles; Male; Motor Activity; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Risperidone; Serotonin Antagonists | 1988 |
Biochemical profile of risperidone, a new antipsychotic.
Topics: Animals; Antipsychotic Agents; Blood Platelets; Cerebral Cortex; Dopamine; Ergolines; Female; Haloperidol; Isoxazoles; Models, Molecular; Norepinephrine; Oxazoles; Phosphatidic Acids; Piperidines; Quinpirole; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Ritanserin; X-Ray Diffraction | 1988 |
Differential effects of the new antipsychotic risperidone on large and small motor movements in rats: a comparison with haloperidol.
Topics: Animals; Antipsychotic Agents; Dose-Response Relationship, Drug; Haloperidol; Isoxazoles; Male; Motor Activity; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Risperidone | 1988 |
Risperidone (R 64 766), a potent and complete LSD antagonist in drug discrimination by rats.
Topics: Animals; Discrimination, Psychological; Dose-Response Relationship, Drug; Generalization, Stimulus; Isoxazoles; Lysergic Acid Diethylamide; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Risperidone | 1989 |
Therapeutic effect and safety of increasing doses of risperidone (R 64766) in psychotic patients.
Topics: Adult; Aged; Antipsychotic Agents; Blood Pressure; Electrocardiography; Female; Hormones; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Piperidines; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone | 1989 |
Receptor occupancy by ritanserin and risperidone measured using ex vivo autoradiography.
Topics: Animals; Brain; Dopamine Antagonists; Isoxazoles; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Serotonin; Risperidone; Ritanserin; Serotonin Antagonists | 1989 |
Differential effects of the new antipsychotic risperidone on sleep and wakefulness in the rat.
Topics: Animals; Antipsychotic Agents; Isoxazoles; Male; Oxazoles; Piperidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Risperidone; Sleep; Wakefulness | 1989 |
Zonisamide usage.
Topics: Epilepsies, Myoclonic; Humans; Isoxazoles; Kidney Calculi; Oxazoles; Zonisamide | 1989 |
Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures.
Topics: Animals; Anticonvulsants; gamma-Aminobutyric Acid; Isoniazid; Isoxazoles; Male; Nervous System; Neuroglia; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Seizures | 1989 |
Clearance of a persistent human enterovirus infection of the mouse central nervous system by the antiviral agent disoxaril.
Topics: Animals; Antiviral Agents; Brain; Cyclophosphamide; Disease Models, Animal; Drug Resistance, Microbial; Enterovirus Infections; Immunosuppression Therapy; Isoxazoles; Male; Mice; Mice, Inbred BALB C; Oxazoles; Poliomyelitis; Poliovirus | 1989 |
Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound.
Topics: Antiviral Agents; Dose-Response Relationship, Drug; Drug Resistance, Microbial; HeLa Cells; Humans; Isoxazoles; Models, Molecular; Molecular Conformation; Molecular Structure; Mutation; Oxazoles; Rhinovirus; Viral Plaque Assay | 1989 |
Evaluation and synthesis of aminohydroxyisoxazoles and pyrazoles as potential glycine agonists.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Detergents; Glycine; Isoxazoles; Models, Molecular; Oxazoles; Pyrazoles; Quaternary Ammonium Compounds; Rats; Receptors, Glycine; Receptors, Neurotransmitter; Spinal Cord; Structure-Activity Relationship | 1989 |
GABAergic drugs and lordosis behavior in the female rat.
Topics: Alkynes; Aminocaproates; Animals; Baclofen; Bicuculline; Estradiol; Female; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Sexual Behavior, Animal; Taurine | 1989 |
In vitro and in vivo activities of WIN 54954, a new broad-spectrum antipicornavirus drug.
Topics: Animals; Animals, Suckling; Antiviral Agents; Coxsackievirus Infections; Culture Media; Echovirus Infections; Female; Isoxazoles; Mice; Mice, Inbred ICR; Oxazoles; Picornaviridae; Rhinovirus; Viral Plaque Assay; Virus Replication | 1989 |
Broxaterol: a new beta2-adrenoceptor agonist for the treatment of reversible airways disease. Proceedings of the satellite symposium. Budapest, September 8, 1988.
Topics: Adrenergic beta-Agonists; Asthma; Bronchitis; Humans; Isoxazoles; Oxazoles | 1989 |
Remarks on broxaterol.
Topics: Adrenergic alpha-Agonists; Asthma; Bronchodilator Agents; Humans; Isoxazoles; Oxazoles | 1989 |
Recovery of the activities of IMP dehydrogenase and GMP synthase after treatment with tiazofurin and acivicin in hepatoma cells in vitro.
Topics: Animals; Carbon-Nitrogen Ligases; Cycloheximide; Drug Interactions; IMP Dehydrogenase; Isoxazoles; Ketone Oxidoreductases; Ligases; Liver Neoplasms, Experimental; Oxazoles; Ribavirin; Ribonucleosides; Time Factors; Tumor Cells, Cultured | 1989 |
Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Drug Resistance; Genetic Variation; Glutamine; Isoxazoles; Kinetics; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Oxazoles; Phosphoribosyl Pyrophosphate | 1985 |
3-Methylisoxazol-5-one, an artefact from acetoacetic acid formed during urinary organic acid analysis.
Topics: Acetoacetates; Carboxylic Acids; Child, Preschool; False Positive Reactions; Humans; Isoxazoles; Lactates; Lactic Acid; Mass Spectrometry; Metabolism, Inborn Errors; Molecular Weight; Oxazoles | 1989 |
Antifungal activity of novel 5-carbonyl derivatives of 3-phenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidines.
Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Oxazoles | 1989 |
Novel 5-substituted 3-(2-naphthalenyl)-3-(1H-imidazol-l-ylmethy)-2-methylisoxazolidine derivatives.
Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Naphthalenes; Oxazoles | 1989 |
Determination of succinylacetone and succinylacetoacetate in physiological samples as the common product 5(3)-methyl-3(5)-isoxazole propionic acid using an isotope dilution method and mass spectrometry.
Topics: Acetoacetates; Gas Chromatography-Mass Spectrometry; Heptanoates; Heptanoic Acids; Humans; Isotopes; Isoxazoles; Mass Spectrometry; Nitrogen Isotopes; Oxazoles; Tyrosine | 1989 |
Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Autoantibodies; Autoimmune Diseases; Basement Membrane; Cyclosporins; Isoxazoles; Kidney Tubules; Leflunomide; Nephritis, Interstitial; Oxazoles; Rats; Rats, Inbred BN | 1989 |
Enzymic synthesis of two glucuronides of the hydroxyisoxazole GABA-agonist, THIP, and the in vivo glucuronidation of THIP in rat.
Topics: Animals; Chromatography, High Pressure Liquid; Glucuronates; Glucuronidase; Hydrolysis; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Microsomes, Liver; Oxazoles; Rabbits; Rats; Rats, Inbred Strains; Spectrophotometry, Ultraviolet | 1989 |
Synthesis of some pyrazoline and isoxazolin derivatives as possible fungicides.
Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Pyrazoles | 1989 |
Studies on antifungal agents. 19. Effect of the C-5-aromatic substitution on the in vitro activity of novel 3,5-substituted isoxazolidines.
Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Chemical Phenomena; Chemistry; Fungi; Isoxazoles; Oxazoles; Trichophyton | 1989 |
Studies on antifungal agents. 20. Effect of the nitrogen substitution on the in vitro activity of novel 3,5-substituted isoxazolidines.
Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Chemical Phenomena; Chemistry; Isoxazoles; Nitrogen; Oxazoles; Trichophyton | 1989 |
Animal behavioral and neurochemical effects of the CNS toxic amino acid antitumor agent, acivicin.
Topics: Action Potentials; Amino Acids; Animals; Antibiotics, Antineoplastic; Avoidance Learning; Behavior, Animal; Brain Chemistry; Cats; Discrimination, Psychological; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Macaca mulatta; Male; Mice; Neurons; Oxazoles; Rats; Rats, Inbred F344 | 1989 |
Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells.
Topics: Antimetabolites; Cell Line; Cisplatin; Drug Combinations; Growth Inhibitors; Humans; Isoxazoles; Lung Neoplasms; Oxazoles; Thymidine Kinase; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
Isoxazoles V: chemical stability of diisoxazolylnaphthoquinone in aqueous solution.
Topics: Catalysis; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Drug Stability; Hydrogen-Ion Concentration; Isoxazoles; Kinetics; Oxazoles; Temperature | 1989 |
Inhibition of the mitochondrial phosphate carrier by a reaction with a carboxyl group reagent.
Topics: Animals; Binding, Competitive; Biological Transport; Borohydrides; Carrier Proteins; Cattle; Indicators and Reagents; Isoxazoles; Liposomes; Mitochondria, Heart; Oxazoles; Phosphate-Binding Proteins; Phosphates | 1989 |
Selection of orally active antifungal agents from 3,5-substituted isoxazolidine derivatives based on acute efficacy-safety profiles.
Topics: Administration, Oral; Analgesics; Animals; Anticonvulsants; Antifungal Agents; Female; Isoxazoles; Male; Mice; Microbial Sensitivity Tests; Nervous System Diseases; Oxazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1989 |
[Effect of bucid on oxidation-reduction processes in the microsomes and mitochondria of the animal liver].
Topics: Animals; Cytochrome P-450 Enzyme System; Enzyme Activation; Isoxazoles; Lipid Peroxidation; Male; Microsomes, Liver; Mitochondria, Liver; Oxazoles; Oxidation-Reduction; Rats | 1989 |
Reaction of Woodward's reagent K with D-xylose isomerases. Modification of an active site carboxylate residue.
Topics: Aldose-Ketose Isomerases; Binding Sites; Carbohydrate Epimerases; Indicators and Reagents; Isoxazoles; Kinetics; Ligands; Oxazoles | 1989 |
New isoxazole derivatives provided with antihypertensive activity.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Binding, Competitive; Chemical Phenomena; Chemistry; Clonidine; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Male; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxazoles; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred Strains; Rats, Inbred WKY; Vas Deferens; Yohimbine | 1989 |
Effects of GABA, THIP, and potassium on excitability of myelinated axons of isolated amphibian spinal roots.
Topics: Anesthetics; Animals; Axons; gamma-Aminobutyric Acid; In Vitro Techniques; Isoxazoles; Myelin Sheath; Oxazoles; Potassium; Rana catesbeiana; Spinal Cord | 1989 |
Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin.
Topics: Antibiotics, Antineoplastic; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Isoxazoles; Kinetics; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Leukocytes; Oxazoles; Reference Values; Tumor Cells, Cultured | 1989 |
Inhibition of poliovirus uncoating by disoxaril (WIN 51711).
Topics: Antiviral Agents; Capsid; Depression, Chemical; Endocytosis; HeLa Cells; Humans; Isoxazoles; Lysosomes; Oxazoles; Poliovirus; RNA, Viral; Virus Replication | 1987 |
Effect of gamma-aminobutyric acidA receptor agonists and antagonists on the release of enkephalin-containing peptides from dog adrenal gland.
Topics: Adrenal Medulla; Analgesics; Animals; Bicuculline; Catecholamines; Dogs; Electric Stimulation; Enkephalins; Female; Isoxazoles; Oxazoles; Receptors, GABA-A; Splanchnic Nerves | 1987 |
Enantiomeric effects of homologues of disoxaril on the inhibitory activity against human rhinovirus-14.
Topics: Antiviral Agents; Computer Simulation; Humans; Isoxazoles; Models, Molecular; Oxazoles; Rhinovirus; Stereoisomerism; Structure-Activity Relationship; X-Ray Diffraction | 1988 |
Lack of GABAergic modulation of acetylcholine turnover in the rat thalamus.
Topics: Acetylcholine; Animals; Brain Chemistry; Diazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Thalamus | 1988 |
GABA-related drugs modulate the behavioral effects of lorazepam.
Topics: Animals; Behavior, Animal; Drug Synergism; gamma-Aminobutyric Acid; Isoxazoles; Lorazepam; Male; Oxazoles; Receptors, GABA-A; Saimiri | 1988 |
Temporal development of GABA agonist induced alterations in ultrastructure and GABA receptor expression in cultured cerebellar granule cells.
Topics: Animals; Cells, Cultured; Cerebellum; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Microscopy, Electron; Organelles; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Time Factors | 1987 |
GABA agonist promoted formation of low affinity GABA receptors on cerebellar granule cells is restricted to early development.
Topics: Animals; Cells, Cultured; Cerebellar Cortex; Isoxazoles; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1988 |
[3H]zonisamide binding in rat brain.
Topics: Animals; Anticonvulsants; Brain; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptosomes; Zonisamide | 1988 |
Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.
Topics: Animals; Bicuculline; Brain Chemistry; Chemical Phenomena; Chemistry; Diazepam; gamma-Aminobutyric Acid; Glycine; In Vitro Techniques; Isoxazoles; Oxazoles; Piperidines; Pyrrolidines; Rats; Receptors, GABA-A; Synaptic Membranes | 1987 |
Use of acivicin in the determination of rate constants for turnover of rat renal gamma-glutamyltranspeptidase.
Topics: Animals; gamma-Glutamyltransferase; Goats; Immunoglobulin G; Isoxazoles; Kidney; Kinetics; Mathematics; Oxazoles; Rats; Rats, Inbred Strains | 1985 |
Effect of inhibition of gamma-glutamyltranspeptidase by AT-125 (acivicin) on glutathione and cysteine levels in rat brain and plasma.
Topics: Animals; Antibiotics, Antineoplastic; Brain; Cysteine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains | 1985 |
Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles.
Topics: Animals; Antipsychotic Agents; Corpus Striatum; In Vitro Techniques; Isoxazoles; Male; Mice; Motor Activity; Oxazoles; Piperidines; Spiperone; Structure-Activity Relationship | 1985 |
Excitatory amino acids: studies on the biochemical and chemical stability of ibotenic acid and related compounds.
Topics: Animals; Brain; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Decarboxylation; Glutamates; Glutamic Acid; Hot Temperature; Hydrogen-Ion Concentration; Ibotenic Acid; Isoxazoles; Liver; Mice; Muscimol; Oxazoles; Pregnancy Proteins | 1985 |
Synthesis and biological evaluation of 1-(1,2-benzisothiazol-3-yl)- and (1,2-benzisoxazol-3-yl)piperazine derivatives as potential antipsychotic agents.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Binding, Competitive; Catalepsy; Cerebral Cortex; Corpus Striatum; Isoxazoles; Male; Models, Molecular; Norepinephrine; Oxazoles; Physostigmine; Piperazines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Receptors, Dopamine; Receptors, Dopamine D2; Receptors, Serotonin; Sleep; Spiro Compounds; Stereotyped Behavior; Structure-Activity Relationship; Thiazoles | 1986 |
New isoxazole derivatives with a potent and selective beta 2-adrenergic activity.
Topics: Adrenergic beta-Antagonists; Animals; Bronchodilator Agents; Chemical Phenomena; Chemistry; Dihydroalprenolol; Female; Guinea Pigs; Histamine; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Muscle, Smooth; Oxazoles; Rats; Serotonin; Trachea | 1986 |
Effect of acivicin on glutamine transport by rat renal brush border membrane vesicles.
Topics: Amino Acids; Animals; Biological Transport; gamma-Glutamyltransferase; Glucose; Glutamine; In Vitro Techniques; Isoxazoles; Kidney Cortex; Microvilli; Oxazoles; Rats | 1986 |
Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism.
Topics: Animals; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Kidney Tubules; Male; Methionine Sulfoximine; Oxazoles; Rats | 1987 |
Embryotoxicity elicited by inhibition of gamma-glutamyltransferase by Acivicin and transferase antibodies in cultured rat embryos.
Topics: Animals; Embryo, Mammalian; gamma-Glutamyltransferase; Immunoglobulin G; Isoxazoles; Organ Culture Techniques; Oxazoles; Proteins; Rats; Rats, Inbred Strains | 1987 |
[Comparison of the effectiveness and tolerance of a new beta-2 stimulant (broxaterol) vs. salbutamol in patients with chronic obstructive bronchopneumopathy].
Topics: Adrenergic beta-Agonists; Adult; Aged; Albuterol; Female; Forced Expiratory Volume; Humans; Isoxazoles; Lung Diseases, Obstructive; Male; Middle Aged; Oxazoles; Vital Capacity | 1987 |
Effects of AT-125 on the nephrotoxicity of hexachloro-1,3-butadiene in rats.
Topics: Animals; Butadienes; gamma-Glutamyltransferase; Glycosuria; Isoxazoles; Kidney Diseases; Kidney Function Tests; Male; Oxazoles; Rats; Rats, Inbred Strains; Urine | 1988 |
Acivicin inhibits Crithidia fasciculata growth in a serum-free medium and inactivates carbamoyl-phosphate synthetase II in vivo.
Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Count; Cells, Cultured; Crithidia; Culture Media; Cytidine; Guanosine; Isoxazoles; Oxazoles | 1988 |
Synthesis and structure-activity studies of some disubstituted phenylisoxazoles against human picornavirus.
Topics: Antiviral Agents; Coronaviridae; Humans; Isoxazoles; Oxazoles; Structure-Activity Relationship | 1989 |
Effects of unilateral microinjections of GABAergic drugs into the inferior colliculus on auditory evoked potentials and on audiogenic seizure susceptibility.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Bicuculline; Evoked Potentials, Auditory; Functional Laterality; gamma-Aminobutyric Acid; Inferior Colliculi; Isoxazoles; Male; Microinjections; Oxazoles; Rats; Rats, Inbred Strains; Reference Values; Seizures | 1989 |
Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.
Topics: 3-Mercaptopropionic Acid; Animals; Anticonvulsants; Brain Chemistry; Drug Synergism; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Neurotransmitter Uptake Inhibitors; Oxazoles; Pentylenetetrazole; Seizures | 1985 |
A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen.
Topics: Analgesics; Animals; Baclofen; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Oxazoles; Postural Balance; Receptors, GABA-A | 1985 |
Isoxazoles with antipicornavirus activity.
Topics: Animals; Antiviral Agents; Isoxazoles; Mice; Mice, Inbred ICR; Oxazoles; Picornaviridae; Picornaviridae Infections; Structure-Activity Relationship | 1985 |
Synthesis and pharmacological evaluation of cis-2,3,3a,4,5,6,7,7a-octahydro-3-oxoisoxazolo[5,4-c]pyridine: a structural analogue of the GABA agonist THIP.
Topics: Animals; Anticonvulsants; Cerebellum; Electrophysiology; Female; Isoxazoles; Male; Mice; Muscimol; Oxazoles; Rats; Receptors, GABA-A | 1985 |
In vitro activity of WIN 51711, a new broad-spectrum antipicornavirus drug.
Topics: Antiviral Agents; Culture Media; Enterovirus; HeLa Cells; Humans; Isoxazoles; Oxazoles; Picornaviridae; Rhinovirus; Time Factors; Viral Plaque Assay; Virus Replication | 1985 |
[[(4,5-Dihydro-2-oxazolyl)phenoxy]alkyl]isoxazoles. Inhibitors of picornavirus uncoating.
Topics: Animals; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Isoxazoles; Mice; Oxazoles; Picornaviridae Infections; Poliovirus; Rhinovirus; Structure-Activity Relationship; Time Factors; Virus Replication | 1985 |
Elicitation of conspecific attack or defense in the male rat by intraventricular injection of a GABA agonist or antagonist.
Topics: Aggression; Animals; Bicuculline; Brain; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A; Synaptic Transmission | 1985 |
Autoradiographic localization of binding sites for the gamma-aminobutyric acid analogues 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP)isoguvacine and baclofen on cultured neurons of rat cerebellum and spinal cord.
Topics: Animals; Animals, Newborn; Autoradiography; Baclofen; Binding Sites; Cells, Cultured; Cerebellum; Fetus; Isonicotinic Acids; Isoxazoles; Oxazoles; Rats; Receptors, GABA-A; Spinal Cord | 1985 |
Glycine antagonists. Synthesis, structure, and biological effects of some bicyclic 5-isoxazolol zwitterions.
Topics: Animals; Glycine; In Vitro Techniques; Isoxazoles; Magnetic Resonance Spectroscopy; Molecular Conformation; Oxazoles; Rats; Receptors, GABA-A; Spectrophotometry, Infrared; Structure-Activity Relationship | 1986 |
Effects of gamma-aminobutyric acid (GABA) receptor agonists on the neurotoxicity and anticonvulsant activity of barbiturates in mice.
Topics: Animals; Anticonvulsants; Baclofen; Barbiturates; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Nervous System; Oxazoles; Receptors, GABA-A; Seizures | 1986 |
Quantitative determination of acivicin in bulk drug and pharmaceutical formulations by ion-pair high-performance liquid chromatography.
Topics: Antineoplastic Agents; Benzyl Alcohol; Benzyl Alcohols; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Isoxazoles; Oxazoles; Perchlorates; Powders; Solutions | 1986 |
GABA-agonists induce the formation of low-affinity GABA-receptors on cultured cerebellar granule cells via preexisting high affinity GABA receptors.
Topics: Animals; Bicuculline; Cells, Cultured; Cerebellum; Intracellular Membranes; Isoxazoles; Kinetics; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1986 |
Glycine antagonists structurally related to 4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridin-3-ol inhibit binding of [3H]strychnine to rat brain membranes.
Topics: Animals; Anions; Binding, Competitive; Cell Membrane; Chlorides; Choline; GABA Antagonists; Glycine; Isoxazoles; Male; Medulla Oblongata; Oxazoles; Pons; Rats; Rats, Inbred Strains; Receptors, Glycine; Receptors, Neurotransmitter; Sodium Chloride; Strychnine | 1986 |
Prevention of rhinovirus and poliovirus uncoating by WIN 51711, a new antiviral drug.
Topics: Antiviral Agents; Cells, Cultured; Centrifugation, Density Gradient; Hot Temperature; Humans; Isoxazoles; Oxazoles; Poliovirus; Rhinovirus; Sucrose; Time Factors; Uridine; Virus Replication | 1986 |
Phase II study of acivicin in non-small cell lung cancer: a National Cancer Institute of Canada Study.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Carcinoma, Non-Small-Cell Lung; Cognition Disorders; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Male; Middle Aged; Oxazoles | 1986 |
Structure-activity studies of 5-[[4-(4,5-dihydro-2-oxazolyl) phenoxy]alkyl]-3-methylisoxazoles: inhibitors of picornavirus uncoating.
Topics: Antiviral Agents; Humans; Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Rhinovirus; Species Specificity; Structure-Activity Relationship | 1987 |
[Changes in the ligand affinity of benzodiazepine receptors in the presence of 4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol (THIP)].
Topics: Animals; Brain; Depression, Chemical; Dose-Response Relationship, Drug; Flunitrazepam; In Vitro Techniques; Isoxazoles; Ligands; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Effect of THIP and SL 76002, two clinically experimented GABA-mimetic compounds, on anterior pituitary GABA receptors and prolactin secretion in the rat.
Topics: Animals; Anticonvulsants; Bicuculline; Binding, Competitive; Female; gamma-Aminobutyric Acid; Haloperidol; Isoxazoles; Kinetics; Male; Muscimol; Ovariectomy; Oxazoles; Pituitary Gland, Anterior; Prolactin; Rats; Rats, Inbred Strains; Receptors, GABA-A | 1987 |
Hypnotic action of pentobarbital in mice: a possible mechanism.
Topics: Animals; Baclofen; Bicuculline; Isoxazoles; Male; Mice; Oxazoles; Pentobarbital; Receptors, GABA-A; Reflex; Sleep | 1987 |
The GABA agonist THIP, attenuates antinociception in the mouse by modifying central cholinergic transmission.
Topics: Afferent Pathways; Analgesics; Animals; Central Nervous System; Cholinergic Fibers; GABA Antagonists; Isoxazoles; Male; Mice; Oxazoles; Pain; Physostigmine; Synaptic Transmission | 1987 |
Respiratory depressant effects of GABA alpha- and beta-receptor agonists in the cat.
Topics: Animals; Baclofen; Bicuculline; Cats; Female; Heart; Injections, Intravenous; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, GABA-A; Respiration | 1987 |
Studies on antifungal agents. 17. Effects of the C-5-substitution on the in vitro activity of novel 3,5-substituted isoxazolidines.
Topics: Antifungal Agents; Aspergillus fumigatus; Candida albicans; Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Trichophyton | 1988 |
Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils.
Topics: Acetates; Alkynes; Aminocaproates; Aminooxyacetic Acid; Animals; Anticonvulsants; Brain; Diazepam; Drug Tolerance; Epilepsy; Female; gamma-Aminobutyric Acid; Gerbillinae; Isoxazoles; Male; Oxazoles; Valproic Acid | 1986 |
Acivicin reduces tumor growth during total parenteral nutrition (TPN).
Topics: Animals; Antimetabolites; Body Weight; Glutamine; Isoxazoles; Male; Neoplasm Transplantation; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Soft Tissue Neoplasms | 1987 |
Progressive myoclonus epilepsy treated with zonisamide.
Topics: Adult; Epilepsies, Myoclonic; Humans; Isoxazoles; Male; Oxazoles; Zonisamide | 1988 |
6-Sulfanilamidoindazole arthritis in rats: influence of the new anti-inflammatory agent CGP 28237 and of the immunomodulating compound HWA 486 on degree of arthritis and on acute phase reaction.
Topics: Acute-Phase Reaction; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Indans; Indenes; Inflammation; Isoxazoles; Leflunomide; Oxazoles; Rats; Sulfanilamides | 1988 |
Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition.
Topics: Animals; Antimetabolites; Body Weight; Eating; Energy Intake; Insulin; Isoxazoles; Male; Muscle Proteins; Muscles; Organ Size; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1988 |
Synthesis and biological activity of the metabolites of [3,4-bis(4-methoxyphenyl)-5-isoxazolyl]acetic acid.
Topics: Chemical Phenomena; Chemistry; Cyclooxygenase Inhibitors; Isoxazoles; Oxazoles | 1988 |
The antiepileptic effect of zonisamide on patients with refractory seizures and its side effect.
Topics: Adult; Anticonvulsants; Electroencephalography; Epilepsies, Partial; Epilepsy; Epilepsy, Absence; Epilepsy, Temporal Lobe; Epilepsy, Tonic-Clonic; Evoked Potentials; Female; Humans; Isoxazoles; Male; Oxazoles; Zonisamide | 1988 |
The use of carotenoids and oxonol VI as probes for membrane potential in proteoliposomes.
Topics: Adenosine Triphosphatases; Carotenoids; Cyanobacteria; Isoxazoles; Membrane Potentials; Oxazoles; Potassium; Proteolipids | 1985 |
Inducing anesthesia with a GABA analog, THIP.
Topics: Analgesics; Anesthesia, Intravenous; Anesthetics; Animals; Benzodiazepines; gamma-Aminobutyric Acid; Isoxazoles; Ketamine; Male; Mice; Midazolam; Oxazoles; Rats; Rats, Inbred Strains; Sodium Oxybate; Time Factors | 1985 |
Phase I-II trial of acivicin in adult acute leukemia.
Topics: Aged; Antibiotics, Antineoplastic; Drug Evaluation; Humans; Isoxazoles; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Middle Aged; Oxazoles | 1988 |
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
Topics: Adult; Aged; Alanine; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Administration Schedule; Drug Evaluation; Female; Humans; Isoxazoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Oxazoles; Thiadiazoles; Vinblastine | 1988 |
Studies on antifungal agents. 23. Novel substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)- 2-alkylisoxazolidine derivatives.
Topics: Animals; Antifungal Agents; Candidiasis; Imidazoles; Isoxazoles; Ketoconazole; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Mitosporic Fungi; Oxazoles; Rats; Structure-Activity Relationship | 1988 |
Impermeant potential-sensitive oxonol dyes: I. Evidence for an "on-off" mechanism.
Topics: Benzenesulfonates; Cell Membrane Permeability; Chemical Phenomena; Chemistry; Cholesterol; Erythrocytes; Fluorescent Dyes; Humans; Isoxazoles; Lipid Bilayers; Membrane Potentials; Oxazoles; Spectrophotometry, Atomic | 1988 |
Conversion of Woodward's Reagent K in an aqueous medium: mathematical analysis applied to enzyme modification.
Topics: Indicators and Reagents; Isoxazoles; Kinetics; Mathematics; Models, Chemical; NAD; Oxazoles; Oxidation-Reduction; Spectrophotometry, Ultraviolet; Transketolase | 1988 |
The effects of acivicin on glutamine transport by renal basolateral membrane vesicles.
Topics: Alanine; Animals; Biological Transport; Cell Membrane; Glutamine; Isoxazoles; Kidney; Oxazoles; Rats | 1988 |
Synthesis and antifungal activity of novel isoxazolidine compounds.
Topics: Animals; Antifungal Agents; Candidiasis, Vulvovaginal; Drug Design; Female; Fungi; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Rats; Structure-Activity Relationship | 1988 |
Substituted 5-phenoxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidines. Antifungal activity and structure-activity relationship studies.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Structure-Activity Relationship | 1988 |
In vitro antifungal activity of novel substituted 3,5-diphenyl-3-(1H-imidazol-1-ylmethyl)-2-methylisoxazolidine derivatives.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
cis-3-(substituted phenyl)-3-(1H-imidazol-1-ylmethyl)-2-methyl-5-([(substituted phenyl)thio(or amino)]methyl)isoxazolidines. In vitro antifungal activity and structure-activity relationships.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
3-(substituted phenyl)-3-(1H-1,2,4-triazol-1-ylmethyl)-2-methyl-5- [(substituted phenoxy)methyl]-isoxazolidine derivatives. Structure-activity relationships.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
cis-5-alkoxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
In vitro antifungal activity of novel substituted 3,5-diphenyl-3-(1H-1,2,4-triazol-1-ylmethyl)-2- methylisoxazolidine derivatives.
Topics: Antifungal Agents; Fungi; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship; Triazoles | 1988 |
In vitro antifungal activity and structure-activity relationship studies of novel cis-5-acyloxyalkyl-3-phenyl-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidine derivatives.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
cis-5-alkyl(or alkenyl)-3-phenyl-3-(1H-imidazole-1-ylmethyl)-2- methylisoxazolidine derivatives. In vitro antifungal activity and structure-activity relationships.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
Novel 5-phenyl(or phenoxyalkyl)-3-(2-furanyl)-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidines. In vitro antifungal activity.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
In vitro activity of novel 5-(phenyl or phenoxyalkyl)-3-(2-thienyl)-3-(1H-imidazol-1-ylmethyl)-2- methylisoxazolidines.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
In vitro activity of novel 5-carbonyl derivatives of 3-phenyl-3-(1H-imidazol-1-ylmethyl)- 2-methyl-isoxazolidines.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
In vitro activity of novel cis-5-substituted-3-(2-naphthalenyl)-3-(1H-imidazol-1-ylmethyl)- 2-methylisoxazolidine derivatives.
Topics: Antifungal Agents; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Structure; Oxazoles; Structure-Activity Relationship | 1988 |
[Studies on the metabolisms of azolecarboxylic acids closely related to the fusaric acid(5-butylpyridine-2-carboxylic acid)].
Topics: Administration, Oral; Animals; Azoles; Carboxylic Acids; Chemical Phenomena; Chemistry; Fusaric Acid; Gas Chromatography-Mass Spectrometry; Isoxazoles; Male; Oxazoles; Picolinic Acids; Pyrazoles; Rats; Rats, Inbred Strains | 1988 |
Amplification by glycine of the effect of the GABA transport inhibitor THPO on synaptosomal GABA level.
Topics: Amino Acids; Animals; Brain; gamma-Aminobutyric Acid; Glycine; Isoxazoles; Male; Mice; Oxazoles; Synaptosomes | 1988 |
[Thiophene as a structural element in physiologically active substances. 17. Thienoisoxazoles through nucleophile substitution].
Topics: Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Thiophenes | 1988 |
Chronic toxicity of the anticonvulsant zonisamide in beagle dogs.
Topics: Administration, Oral; Animals; Anticonvulsants; Body Weight; Dogs; Eating; Electrocardiography; Isoxazoles; Liver; Oxazoles; Serum Albumin; Sex Factors; Time Factors; Zonisamide | 1988 |
Impermeant potential-sensitive oxonol dyes: II. The dependence of the absorption signal on the length of alkyl substituents attached to the dye.
Topics: Adsorption; Cholesterol; Hydrocarbons; Isoxazoles; Lipid Bilayers; Oxazoles | 1988 |
Impermeant potential-sensitive oxonol dyes: III. The dependence of the absorption signal on membrane potential.
Topics: Adsorption; Cholesterol; Isoxazoles; Lipid Bilayers; Mathematics; Membrane Potentials; Oxazoles; Thermodynamics | 1988 |
5-( [aryl or aryloxy (or thio)]methyl)-3-(1H-imidazol-1-ylmethyl)-3- (2-thienyl)-2-methylisoxazolidine derivatives as novel antifungal agents.
Topics: Antifungal Agents; Chemical Phenomena; Chemistry; Fungi; Imidazoles; Isoxazoles; Microbial Sensitivity Tests; Molecular Conformation; Oxazoles; Thiophenes | 1988 |
The structure of (1,2-benzisoxazol-3-yl)methanesulfonamide: a novel antiepileptic drug.
Topics: Anticonvulsants; Hydrogen Bonding; Isoxazoles; Models, Molecular; Molecular Conformation; Oxazoles; X-Ray Diffraction; Zonisamide | 1988 |
Comparisons of ketoconazole, PR 969-566, PR 967-234, and PR 967-248 as antifungals in vitro and in the rat model of candidal vaginitis based on efficacy/safety profiles.
Topics: Animals; Antifungal Agents; Candida; Candidiasis, Vulvovaginal; Disease Models, Animal; Female; Fungi; Isoxazoles; Ketoconazole; Microbial Sensitivity Tests; Oxazoles; Rats | 1988 |
Reduction of tumor growth following treatment with a glutamine antimetabolite.
Topics: Amino Acids; Animals; Antibiotics, Antineoplastic; Antimetabolites; Body Weight; Energy Intake; Glutamine; Isoxazoles; Male; Methylcholanthrene; Oxazoles; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1988 |
Cardioactivity and solid-state structure of two 4-isoxazolyldihydropyridines related to the 4-aryldihydropyridine calcium-channel blockers.
Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Guinea Pigs; Heart; In Vitro Techniques; Isoxazoles; Oxazoles; Structure-Activity Relationship; X-Ray Diffraction | 1988 |
Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin.
Topics: Animals; Aspartate Carbamoyltransferase; Bone Marrow; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Deoxycytidine Kinase; Isoxazoles; Ligases; Orotidine-5'-Phosphate Decarboxylase; Oxazoles; Rats; Ribavirin; Ribonucleoside Diphosphate Reductase; Ribonucleosides; Thymidine Monophosphate; Thymidylate Synthase | 1988 |
Functional responses to baclofen and 4,5,6,7-tetrahydroisoxazolo (5,4-c) pyridin-3-ol (THIP) in rats repeatedly treated with desipramine.
Topics: Analgesics; Animals; Baclofen; Behavior, Animal; Body Temperature; Desipramine; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains | 1988 |
Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and acivicin in sensitive and resistant tumor cell lines.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Azo Compounds; Biological Transport; Colonic Neoplasms; Diazooxonorleucine; Drug Resistance; Glutamine; Humans; Isoxazoles; Kinetics; Leukemia P388; Lung Neoplasms; Mice; Neoplasms, Experimental; Oxazoles; Tumor Cells, Cultured | 1988 |
The effect of the GABA-A agonist THIP on regional cortical blood flow in humans. A new test of hemispheric dominance.
Topics: Adolescent; Adult; Behavior; Carotid Arteries; Cerebrovascular Circulation; Dominance, Cerebral; Electroencephalography; gamma-Aminobutyric Acid; Humans; Injections, Intra-Arterial; Isoxazoles; Middle Aged; Neural Inhibition; Oxazoles; Synapses | 1988 |
Gamma-aminobutyric acid agonist-induced alterations in the ultrastructure of cultured cerebellar granule cells is restricted to early development.
Topics: Animals; Cells, Cultured; Cerebellum; Cytoplasm; Endoplasmic Reticulum; gamma-Aminobutyric Acid; Golgi Apparatus; Isoxazoles; Microscopy, Electron; Oxazoles; Rats; Rats, Inbred Strains | 1988 |
Synthesis of the tumorigenic 3,4-dihydrodiol metabolites of dibenz[a,j]anthracene and 7,14-dimethyldibenz[a,j]anthracene.
Topics: Animals; Benz(a)Anthracenes; Chemical Phenomena; Chemistry; Female; Isoxazoles; Mice; Oxazoles; Papilloma; Skin Neoplasms; Structure-Activity Relationship | 1988 |
[5-(3-aminopropyl)-isoxazoles: synthesis and antibacterial activity of various derivatives].
Topics: Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry; Isoxazoles; Microbial Sensitivity Tests; Oxazoles | 1988 |
GABAergic modulation of nociceptive threshold: effects of THIP and bicuculline microinjected in the ventral medulla of the rat.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Isoxazoles; Male; Medulla Oblongata; Microinjections; Oxazoles; Pain; Raphe Nuclei; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1988 |
Pharmacokinetics and metabolism of alpha-[(dimethylamino)methyl]-2- (3-ethyl-5-methyl-4-isoxazolyl)-1H-indole-3-methanol, a hypoglycemic agent, in man.
Topics: Adolescent; Adult; Biotransformation; Humans; Hypoglycemic Agents; Isoxazoles; Male; Mass Spectrometry; Oxazoles | 1987 |
Inhibition of progesterone secretion and decrease of ovarian blood flow by isoxazole in pregnant rats.
Topics: Animals; Corticosterone; Estradiol; Female; Isoxazoles; Ovary; Oxazoles; Pregnancy; Pregnancy, Animal; Progesterone; Rats; Regional Blood Flow | 1987 |
General pharmacology of the novel antiepileptic compound zonisamide. 1st communication: effects on central nervous system.
Topics: Animals; Anticonvulsants; Brain; Cats; Cerebrovascular Circulation; Cognition; Electroencephalography; Female; Hydrogen-Ion Concentration; Isoxazoles; Male; Mice; Mice, Inbred Strains; Oxazoles; Rats; Rats, Inbred Strains; Reflex; Species Specificity; Zonisamide | 1987 |
General pharmacology of the novel antiepileptic compound zonisamide. 2nd communication: effects on cardiovascular, visceral, renal and blood functions.
Topics: Animals; Anticonvulsants; Autonomic Nervous System; Blood Coagulation; Cats; Digestive System; Dogs; Electrocardiography; Female; Guinea Pigs; Hemodynamics; Hemolysis; In Vitro Techniques; Isoxazoles; Kidney; Male; Mice; Oxazoles; Rats; Zonisamide | 1987 |
GABAergic modulation of the analgesic effects of morphine microinjected in the ventral periaqueductal gray matter of the rat.
Topics: Animals; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Periaqueductal Gray; Picrotoxin; Raphe Nuclei; Rats; Rats, Inbred Strains | 1987 |
Isoxazole derivatives as centrally acting muscle relaxants. III. Synthesis and activity of conformationally restricted analogs.
Topics: Animals; Avoidance Learning; Chemical Phenomena; Chemistry; Isoxazoles; Mice; Molecular Conformation; Muscle Relaxants, Central; Oxazoles; Rats | 1987 |
Phase II study of acivicin as a 72-hr continuous infusion in patients with untreated colorectal cancer. A National Cancer Institute of Canada Clinical Trials Group Study.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Colonic Neoplasms; Drug Evaluation; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Oxazoles; Rectal Neoplasms | 1987 |
Syntheses of 3,6-substituted-4-(3',4',5'-substituted-1'-pyrazolyl)-isoxazo lo[5,4-d] pyrimidines as potential antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Bacteria; Chemical Phenomena; Chemistry; Fungi; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Pyrazoles; Pyrimidines; Rats | 1987 |
Substituted spiro[isoxazolidine-3,2'-tricyclo[3.3.1.1(3,7)]decane] derivatives.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Chemical Phenomena; Chemistry; Edema; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Spiro Compounds | 1987 |
Membrane potential and cation content of osteoblast-like cells (UMR 106) assessed by fluorescent dyes.
Topics: Animals; Barbiturates; Cations; Cell Line; Electrophysiology; Fluorescent Dyes; Hydrogen-Ion Concentration; Intracellular Fluid; Isoxazoles; Membrane Potentials; Osteoblasts; Osteosarcoma; Oxazoles; Rats | 1987 |
Immunopharmacological profile of HWA 486, a novel isoxazol derivative--II. In vivo immunomodulating effects differ from those of cyclophosphamide, prednisolone, or cyclosporin A.
Topics: Animals; Antibody Formation; Antibody-Producing Cells; B-Lymphocytes; Cyclophosphamide; Cyclosporins; Female; Immune System; Isoxazoles; Leflunomide; Luminescent Measurements; Lymphocyte Activation; Mice; Mitogens; Oxazoles; Prednisolone; T-Lymphocytes | 1986 |
Disease modifying activity of HWA 486 in rat adjuvant-induced arthritis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arthritis; Arthritis, Experimental; Cyclosporins; Hypersensitivity, Delayed; In Vitro Techniques; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Oxazoles; Rats; Rats, Inbred Lew | 1987 |
High-performance of liquid chromatographic determination of [3,4-di-(4-methoxyphenyl)-5-isoxazolyl]acetic acid and its metabolites in human plasma and urine.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoxazoles; Oxazoles; Spectrophotometry, Ultraviolet | 1987 |
Yeast enolase carboxyl modification using Woodward's reagent K.
Topics: Amino Acids; Isoxazoles; Kinetics; Oxazoles; Peptide Fragments; Phosphopyruvate Hydratase; Protein Binding; Saccharomyces cerevisiae | 1986 |
Simultaneous determination of Zonisamide and nine other anti-epileptic drugs and metabolites in serum. A comparison of microbore and conventional high-performance liquid chromatography.
Topics: Anticonvulsants; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Isoxazoles; Oxazoles; Zonisamide | 1987 |
Platinum(IV) chloride complexes with heterocyclic ligands.
Topics: Animals; Antineoplastic Agents; Ethylenediamines; Imidazoles; Indicators and Reagents; Isoxazoles; Leukemia L1210; Male; Mice; Organoplatinum Compounds; Oxazoles; Spectrophotometry; Structure-Activity Relationship | 1987 |
Phase II trial of acivicin in malignant mesothelioma.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Isoxazoles; Male; Mesothelioma; Middle Aged; Oxazoles; Peritoneal Neoplasms; Pleural Neoplasms | 1987 |
Inactivation of Crithidia fasciculata carbamoyl phosphate synthetase II by the antitumor drug acivicin.
Topics: Ammonia; Animals; Antineoplastic Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Crithidia; Enzyme Activation; Enzyme Inhibitors; Isoxazoles; Ligases; Oxazoles; Stimulation, Chemical | 1987 |
5-Aryl-3-(2-arylvinyl)-2-methylisoxazolium tetrafluoborates as selective antibacterial compounds.
Topics: Anti-Bacterial Agents; Bacteria; Isoxazoles; Microbial Sensitivity Tests; Onium Compounds; Oxazoles; Vinyl Compounds | 1986 |
[Synthesis and antimicrobial activity of 3-nitroisoxazole derivatives].
Topics: Anti-Bacterial Agents; Bacteria; Chemical Phenomena; Chemistry; Isoxazoles; Microbial Sensitivity Tests; Nitro Compounds; Oxazoles | 1987 |
Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines.
Topics: Antimetabolites; Azo Compounds; Cell Cycle; Cell Line; Colonic Neoplasms; Diazooxonorleucine; Drug Evaluation, Preclinical; Glutaminase; Glutamine; Humans; Isoxazoles; Lung Neoplasms; Neoplasms, Experimental; Oxazoles | 1987 |
Increasing anticonvulsant effect of AD-810 (zonisamide) in aging BDF1 mice.
Topics: Aging; Animals; Anticonvulsants; Brain; Dose-Response Relationship, Drug; Isoxazoles; Mice; Oxazoles; Zonisamide | 1987 |
Bicuculline-sensitive and insensitive effects of THIP on the binding of [3H]flunitrazepam.
Topics: Animals; Bicuculline; Brain; Dose-Response Relationship, Drug; Flunitrazepam; gamma-Aminobutyric Acid; Isoxazoles; Male; Osmolar Concentration; Oxazoles; Rats; Rats, Inbred Strains; Sodium Chloride; Tritium | 1987 |
Intrathecal administration of pentobarbital and THIP: evidence for descending excitatory and inhibitory modulation of a spinal reflex.
Topics: Analgesics; Animals; Efferent Pathways; Injections, Spinal; Isoxazoles; Male; Neural Inhibition; Oxazoles; Pentobarbital; Rats; Rats, Inbred Strains; Reflex; Spinal Cord | 1987 |
Disposition of alpha-[(dimethylamino)methyl]-2-(3-ethyl-5-methyl-4-isoxazolyl)- 1H-indole-3-methanol (59-801), a hypoglycaemic agent in rats, dogs and monkeys.
Topics: Animals; Dogs; Feces; Female; Hypoglycemic Agents; Isoxazoles; Kinetics; Macaca fascicularis; Male; Oxazoles; Rats; Rats, Inbred Strains; Sex Factors; Species Specificity; Tissue Distribution | 1987 |
Synthesis and spasmolytic activity of aminoalkyl 2-substituted-2-(1,2-benzisoxazol-3-yl)acetates.
Topics: Animals; Chemical Phenomena; Chemistry; Guinea Pigs; In Vitro Techniques; Isoxazoles; Male; Muscle Contraction; Oxazoles; Parasympatholytics | 1987 |
Effect of repeated treatment with a gamma-aminobutyric acid receptor agonist on postnatal neural development in rats.
Topics: Animals; Antigens, Surface; Brain; Cell Adhesion; Cell Adhesion Molecules; gamma-Aminobutyric Acid; Glutamate Decarboxylase; Glutamate Dehydrogenase; Isoxazoles; Nerve Tissue Proteins; Neurons; Organ Size; Oxazoles; Rats; Rats, Inbred Strains | 1987 |
[Thiophene as a structural element of physiologically active compounds. 16. Thienoisoxazoles by substitution at the oxime nitrogen].
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Isoxazoles; Mice; Oxazoles; Rats; Thiophenes | 1987 |
Synthesis and antibacterial properties of 7-[2-(3-substituted-5-isoxazolyl)-2-methoxyiminoacetamido]cep halospora nic acid derivatives.
Topics: Animals; Anti-Bacterial Agents; Bacterial Infections; Biological Availability; Cephalosporins; Isomerism; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Rats; Structure-Activity Relationship | 1987 |
Effect of GABAergic drugs in the behavioral 'despair' test in rats.
Topics: Acetates; Aminooxyacetic Acid; Animals; Baclofen; Behavior, Animal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Male; Motor Activity; Muscimol; Oxazoles; Picrotoxin; Rats | 1986 |
Phase II trial of acivicin in patients with advanced epithelial ovarian carcinoma. A Gynecologic Oncology Group Study.
Topics: Adult; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Nervous System Diseases; Ovarian Neoplasms; Oxazoles | 1986 |
[Anticoagulant isoxazolidine-3,5-diones].
Topics: Animals; Anticoagulants; Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Prothrombin Time; Rats | 1986 |
Acivicin (AT 125, U 42126): isolation and structure of an alkali-induced contaminant.
Topics: Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Drug Contamination; Hydrogen-Ion Concentration; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles | 1986 |
Isoxazole derivatives as centrally acting muscle relaxants. I. Synthesis and activity of 5-(3-aminopropyl)amino-3-phenylisoxazole derivatives.
Topics: Animals; Anticonvulsants; Chemical Phenomena; Chemistry; Isoxazoles; Male; Mice; Mice, Inbred ICR; Muscle Relaxants, Central; Oxazoles; Rats; Rats, Inbred Strains | 1986 |
Isoxazole derivatives as centrally acting muscle relaxants. II. Synthesis and structure-activity relationship of 3-amino-N-(3-phenyl-5-isoxazolyl)propanamides.
Topics: Animals; Chemical Phenomena; Chemistry; Isoxazoles; Male; Mice; Muscle Relaxants, Central; Oxazoles; Rats; Rats, Inbred Strains; Structure-Activity Relationship | 1986 |
Phase II trial of acivicin in patients with advanced colorectal carcinoma.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Leukopenia; Male; Middle Aged; Nausea; Neoplasm Metastasis; Oxazoles; Rectal Neoplasms; Vomiting | 1986 |
Oral efficacy of WIN 51711 in mice infected with human poliovirus.
Topics: Animals; Antiviral Agents; Brain; Female; Humans; Isoxazoles; Mice; Mice, Inbred ICR; Oxazoles; Poliomyelitis; Spinal Cord; Time Factors | 1986 |
Tissue distribution, metabolism, anticonvulsant efficacy and effect on brain amino acid levels of the glia-selective gamma-aminobutyric acid transport inhibitor 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol in mice and chicks.
Topics: Amino Acids; Animals; Anticonvulsants; Biological Transport; Brain; Chickens; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Liver; Male; Mice; Oxazoles; Tissue Distribution | 1986 |
Depression of drug-induced tremor by a new isoxazol derivative in mice.
Topics: Animals; Diazepam; Dose-Response Relationship, Drug; Harmaline; Isoxazoles; Male; Mice; Mice, Inbred ICR; Motor Activity; Oxazoles; Tremor; Tremorine | 1986 |
Use of WIN 51711 to prevent echovirus type 9-induced paralysis in suckling mice.
Topics: Administration, Oral; Animals; Animals, Suckling; Antiviral Agents; Echovirus 9; Echovirus Infections; Injections, Intraperitoneal; Isoxazoles; Mice; Oxazoles; Paralysis; Tissue Distribution | 1986 |
Comparative pharmacokinetics of zonisamide (CI-912) in epileptic patients on carbamazepine or phenytoin monotherapy.
Topics: Adolescent; Adult; Anticonvulsants; Body Weight; Carbamazepine; Drug Therapy, Combination; Epilepsy; Erythrocytes; Female; Humans; Isoxazoles; Kinetics; Male; Oxazoles; Phenytoin; Zonisamide | 1986 |
Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells.
Topics: Animals; Bicarbonates; Carbon Radioisotopes; Cytidine Triphosphate; Guanosine Triphosphate; Isoxazoles; Kinetics; Leukemia L1210; Mice; Naphthoquinones; Oxazoles; Pyrimidines; Uracil Nucleotides | 1986 |
The interaction of potential-sensitive molecular probes with dimyristoylphosphatidylcholine vesicles investigated by 31P-NMR and electron microscopy.
Topics: Benzothiazoles; Carbocyanines; Dimyristoylphosphatidylcholine; Indicators and Reagents; Isoxazoles; Kinetics; Lipid Bilayers; Magnetic Resonance Spectroscopy; Membrane Potentials; Microscopy, Electron; Oxazoles; Pyrimidinones; Quinolines | 1987 |
Synthesis of trifluoromethylisoxazoloazines.
Topics: Amines; Anti-Bacterial Agents; Chemical Phenomena; Chemistry; Isoxazoles; Oxazoles; Phosphorus; Phosphorus Compounds; Pyrimidines | 1986 |
Disease modifying activity of HWA 486 on the development of SLE in MRL/1-mice.
Topics: Animals; Anti-Inflammatory Agents; Autoimmune Diseases; Isoxazoles; Leflunomide; Lupus Erythematosus, Systemic; Mice; Mice, Inbred Strains; Oxazoles | 1986 |
Inactivation by acivicin of rat brain CTP and GMP synthetases and depression of CTP and GTP concentrations.
Topics: Animals; Antibiotics, Antineoplastic; Brain; Carbon-Nitrogen Ligases; Cell Line; Cytidine Triphosphate; Guanosine Triphosphate; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Oxazoles; Rats; Rats, Inbred ACI | 1985 |
The glutamine analog acivicin as antipyrimidine. Studies on the interrelationship between pyrimidine and urea synthesis in liver.
Topics: Animals; Antibiotics, Antineoplastic; Carbamyl Phosphate; Cytosol; Female; Isoxazoles; Liver; Mitochondria, Liver; Orotic Acid; Oxazoles; Pyrimidines; Rats; Rats, Inbred Strains; Urea | 1985 |
The effect of mouse spinal cord transection on the antinociceptive response to the gamma-aminobutyric acid agonists THIP (4,5,6,7-tetrahydroisoxazolo [5,4-c]pyridine-3-ol) and baclofen.
Topics: Analgesics; Animals; Baclofen; Central Nervous System; Clonidine; Cordotomy; Isoxazoles; Male; Mice; Morphine; Oxazoles; Oxotremorine | 1985 |
Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity--I. Disease modifying action on adjuvant arthritis of the rat.
Topics: Animals; Anti-Inflammatory Agents; Arthritis; Arthritis, Experimental; Cyclophosphamide; Immunosuppressive Agents; Isoxazoles; Leflunomide; Lymphocyte Activation; Male; Oxazoles; Radiography; Rats; Rats, Inbred Lew | 1985 |
Modification of carboxyl group at the active site of liquefying alpha-amylase.
Topics: alpha-Amylases; Bacillus; Binding Sites; Isoxazoles; Oxazoles; Protein Binding | 1985 |
Synthesis and antibacterial activity of 3-(2-arylvinylen)-2-isoxazolines.
Topics: Anti-Bacterial Agents; Escherichia coli; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Staphylococcus aureus; Vinyl Compounds | 1985 |
Stimulation of insulin secretion from isolated rat islets by SaRI 59-801.
Topics: Administration, Oral; Animals; Dose-Response Relationship, Drug; Glyburide; Insulin; Insulin Secretion; Islets of Langerhans; Isoxazoles; Male; Mannoheptulose; Oxazoles; Proinsulin; Rats; Rats, Inbred Strains; Tolbutamide | 1985 |
Blockade of "antiabsence" activity of sodium valproate by THIP in rats with petit mal-like seizures. Comparison with ethosuximide.
Topics: Animals; Epilepsy, Absence; Ethosuximide; GABA Antagonists; Injections; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Valproic Acid | 1985 |
Covalent labeling of the nonsubstrate ligand-binding site of glutathione S-transferases with bilirubin-Woodward's reagent K.
Topics: Animals; Bilirubin; Binding Sites; Electrophoresis, Polyacrylamide Gel; Glutathione Transferase; Isoxazoles; Liver; Macromolecular Substances; Molecular Weight; Oxazoles; Rats; Spectrometry, Fluorescence; Sulfobromophthalein | 1986 |
Prolongation of gamma-aminobutyric acid-mediated inhibitory postsynaptic potentials by 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol (THPO).
Topics: Animals; Drug Interactions; Evoked Potentials; gamma-Aminobutyric Acid; Hippocampus; In Vitro Techniques; Iontophoresis; Isoxazoles; Neural Inhibition; Nipecotic Acids; Oxazoles; Rats; Synapses | 1986 |
Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma.
Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Colon; Colonic Neoplasms; Glutamine; Humans; Isoxazoles; Kinetics; Ligases; Oxazoles | 1985 |
Oxonol dyes as monitors of membrane potential: the effect of viruses and toxins on the plasma membrane potential of animal cells in monolayer culture and in suspension.
Topics: Animals; Benzothiazoles; Carbocyanines; Cell Membrane; Isoxazoles; Membrane Potentials; Mice; Mice, Inbred Strains; Oxazoles; Toxins, Biological; Virus Diseases | 1985 |
Effect of L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid on urinary excretion of methylmercury in the mouse.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Feces; Glutathione; Isoxazoles; Methylmercury Compounds; Mice; Mice, Inbred CBA; Oxazoles | 1985 |
[A method of quality control of 3-phenyl-5-methylisoxazole-4-carbonic acid chloranhydride using high performance liquid chromatography].
Topics: Animals; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Female; In Vitro Techniques; Isoxazoles; Male; Oxacillin; Oxazoles; Quality Control; Rabbits; Technology, Pharmaceutical | 1985 |
Blood-brain barrier transport of CI-912: single-passage equilibration of erythrocyte-borne drug.
Topics: Animals; Anticonvulsants; Biological Transport; Blood Proteins; Blood-Brain Barrier; Brain; Capillary Permeability; Erythrocytes; Humans; Isoxazoles; Oxazoles; Protein Binding; Rats; Zonisamide | 1985 |
Quantitation of antitumor agent acivicin in plasma by gas chromatography/mass spectrometry.
Topics: Antibiotics, Antineoplastic; Gas Chromatography-Mass Spectrometry; Humans; Isoxazoles; Oxazoles | 1985 |
Potential biologically active agents. Note II. Synthesis and pharmacological evaluation of some new 3-isoxazolyl-substituted-1,2,3-benzotriazin-4(3H)-ones.
Topics: Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Edema; Isoxazoles; Oxazoles; Rats; Rats, Inbred Strains; Triazines | 1985 |
WIN 51711, a new systematically active broad-spectrum antipicornavirus agent.
Topics: Antiviral Agents; Capsid; Isoxazoles; Oxazoles; Picornaviridae; Viral Proteins | 1985 |
Kinetics of Woodward's Reagent K hydrolysis and reaction with staphylococcal nuclease.
Topics: Benzenesulfonates; Carboxylic Acids; Chemical Phenomena; Chemistry; Computers; Hydrogen-Ion Concentration; Hydrolysis; Hydroxylamines; Imines; Isoxazoles; Mathematics; Methyl Ethers; Models, Chemical; Oxazoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Spectrophotometry, Ultraviolet; Staphylococcus | 1974 |
New isoxazolinone amino acids from Lathyrus odoratus seedlings.
Topics: Amino Acids; Chromatography, Ion Exchange; Chromatography, Paper; Deuterium; Fluorescence; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles; Plants; Quantum Theory; Spectrophotometry, Ultraviolet; Structure-Activity Relationship | 1974 |
[Urovalidin Bracco in the therapy of urinary tract infections in children].
Topics: Anesthetics, Local; Anti-Infective Agents, Urinary; Cycloserine; Drug Combinations; Drug Evaluation; Humans; Isoxazoles; Oxazoles; Oxazolidinones; Phenazopyridine; Pyridines; Urinary Tract Infections | 1973 |
1,2-Benzisoxazole-3-acetamidoxime hydrochloride, a new psychotropic agent.
Topics: Acetamides; Aggression; Animals; Antidepressive Agents; Behavior, Animal; Brain; Brain Chemistry; Dopamine; Dose-Response Relationship, Drug; Electroencephalography; Female; Humans; Ileum; In Vitro Techniques; Isoxazoles; Norepinephrine; Oxazoles; Oximes; Reserpine; Seizures; Sleep; Tranquilizing Agents | 1974 |
Characteristics and distribution of muscimol binding sites in cat visual cortex.
Topics: Animals; Autoradiography; Cats; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Muscimol; Oxazoles; Receptors, GABA-A; Tissue Distribution; Tritium; Visual Cortex | 1984 |
The effect of repeated electroconvulsive shock on the function of THIP, a GABA agonist.
Topics: Animals; Anticonvulsants; Blood-Brain Barrier; Dose-Response Relationship, Drug; Electroshock; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Rats; Rats, Inbred Strains; Receptors, GABA-A; Seizures; Sensory Thresholds | 1984 |
[Potential-dependent interaction of chemical reagents with the sodium channel gating mechanism in a nerve fiber].
Topics: Animals; Carbodiimides; CME-Carbodiimide; Ethyldimethylaminopropyl Carbodiimide; Hydrogen-Ion Concentration; Ion Channels; Isoxazoles; Membrane Potentials; Nerve Fibers; Oxazoles; Rana ridibunda; Sodium | 1984 |
Modulation of the responses to the GABA-mimetics, THIP and piperidine-4-sulphonic acid, by agents which interact with benzodiazepine receptors. An electrophysiological study on cultured mouse neurones.
Topics: Animals; Benzodiazepines; Carbolines; Cells, Cultured; Convulsants; Electrophysiology; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Mice; Midazolam; Neurons; Oxazoles; Piperidines; Receptors, GABA-A | 1984 |
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
Topics: Antibiotics, Antineoplastic; Cells, Cultured; gamma-Glutamyltransferase; Glycine; Half-Life; Humans; Isoxazoles; Oxazoles; Pancreatic Neoplasms; Time Factors | 1980 |
The inhibition of gamma-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(alpha S, 5S)-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
Topics: Animals; Cells, Cultured; gamma-Glutamyltransferase; Glutathione; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Rats | 1980 |
The effect of the glutamine analog, AT-125, on the cell cycle of MCF-7 and BT-20 human breast carcinoma cells using DNA flow cytometry.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line; Cytological Techniques; DNA, Neoplasm; gamma-Glutamyltransferase; Glycine; Humans; Isoxazoles; Oxazoles | 1980 |
Interaction of AT-125, (alpha S,5S)-amino-3-chloro-4,5-dihydroisoxazoleacetic acid, with bovine kidney gamma-glutamyl transpeptidase.
Topics: Anilides; Animals; Cattle; gamma-Glutamyltransferase; Glutamates; Glutamine; Glycine; In Vitro Techniques; Isoxazoles; Kidney; Kinetics; Oxazoles | 1981 |
Differential reversal by scopolamine and THIP of the antistereotypic and cataleptic effects of neuroleptics.
Topics: Amphetamine; Animals; Antipsychotic Agents; Catalepsy; Humans; Isoxazoles; Male; Oxazoles; Rats; Scopolamine; Stereotyped Behavior | 1981 |
Affinity labeling of gamma-glutamyl transpeptidase by glutamine antagonists. Effects of the gamma-glutamyl transferase and proteinase activities.
Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; gamma-Glutamyltransferase; Glycine; Isoxazoles; Kidney; Macromolecular Substances; Oxazoles; Rats; Structure-Activity Relationship | 1980 |
Interaction of the antitumor drug, L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) with renal brush border membranes. Specific labeling of gamma-glutamyl transpeptidase.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; gamma-Glutamyltransferase; Glycine; Isoxazoles; Kidney; Male; Microvilli; Molecular Weight; Oxazoles; Rats | 1980 |
Differential effect of AT-125 on rat renal glutaminase activities.
Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Phosphates; Rats | 1981 |
Effect of AT-125 on in situ renal gamma-glutamyltransferase activity.
Topics: Animals; Antimetabolites; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Isoxazoles; Kidney; Male; Oxazoles; Rats | 1982 |
Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Time Factors | 1982 |
The effect of temperature and chloride ions on the stimulation of [3H]flunitrazepam binding by the muscimol analogues THIP and piperidine-4-sulfonic acid.
Topics: Animals; Anti-Anxiety Agents; Chlorides; Flunitrazepam; gamma-Aminobutyric Acid; Isonicotinic Acids; Isoxazoles; Oxazoles; Piperidines; Rats; Stimulation, Chemical; Temperature; Tritium | 1980 |
The binding mechanism of glutathione and the anti-tumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125;NSC-163501) to gamma-glutamyltransferase.
Topics: Animals; Antineoplastic Agents; Arginine; Binding Sites; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Oxazoles; Phenylglyoxal; Protein Binding; Rats | 1983 |
Absorption, distribution and excretion of 3-(sulfamoyl[14C]methyl)-1,2-benziosoxazole (AD-810) in Rats, Dogs and Monkeys and of AD-810 in Men.
Topics: Animals; Autoradiography; Bile; Dogs; Erythrocytes; Female; Humans; Intestinal Absorption; Isoxazoles; Kinetics; Macaca mulatta; Male; Middle Aged; Oxazoles; Pregnancy; Protein Binding; Rats; Rats, Inbred Strains; Species Specificity; Thiazines; Tissue Distribution; Zonisamide | 1983 |
Cardiovascular effects of THIP in the rat.
Topics: Animals; Blood Pressure; Heart Rate; Hemodynamics; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Picrotoxin; Rats; Rats, Inbred Strains | 1983 |
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Dactinomycin; Deoxyribonucleotides; Glutamine; Humans; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Rats; Rats, Inbred Strains; Ribonucleotides; Sarcoma, Experimental | 1982 |
Synergistic interaction between acivicin (AT-125) and 6-thioguanine in the murine leukemia L1210. Biochemical and cytokinetic considerations.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Guanine Nucleotides; Isoxazoles; Leukemia L1210; Mice; Oxazoles; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thioguanine | 1984 |
Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin.
Topics: Animals; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Drug; IMP Dehydrogenase; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nucleotides; Oxazoles; Pentosephosphates; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Rats; Ribavirin; Ribonucleosides | 1984 |
The interaction of carboxyl group reagents with the Rhodospirillum rubrum F1-ATPase and its isolated beta-subunit.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Calcium; Carbodiimides; Dicyclohexylcarbodiimide; Isoxazoles; Kinetics; Macromolecular Substances; Magnesium; Oxazoles; Phosphates; Photophosphorylation; Proton-Translocating ATPases; Quinolines; Rhodospirillum rubrum | 1983 |
Plasmin-activated prodrugs for cancer chemotherapy. 1. Synthesis and biological activity of peptidylacivicin and peptidylphenylenediamine mustard.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Female; Fibrinolysin; Isoxazoles; Melanoma; Mice; Nitrogen Mustard Compounds; Oligopeptides; Ovarian Neoplasms; Oxazoles; Plasminogen Activators | 1983 |
Therapeutic failure of GABA agonist treatment in Huntington's disease.
Topics: gamma-Aminobutyric Acid; Humans; Huntington Disease; Isoxazoles; Oxazoles | 1984 |
ATP-dependent spectral response of oxonol VI in an ATP-Pi exchange complex.
Topics: Animals; Bile Acids and Salts; Cell-Free System; Fluorescent Dyes; Ionophores; Isoxazoles; Mitochondria; Mitochondrial Proton-Translocating ATPases; Oxazoles; Phospholipids; Proton-Translocating ATPases; Sulfhydryl Reagents | 1984 |
Heterogeneous depression of glucose utilization in the caudate nucleus by GABA agonists.
Topics: Animals; Autoradiography; Blood Glucose; Caudate Nucleus; Isoxazoles; Male; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A | 1981 |
The binding of the GABA agonist [3H]THIP to rat brain synaptic membranes.
Topics: Animals; Brain; GABA Antagonists; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes; Tritium | 1982 |
Orally administered THIP inhibits food intake in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Dose-Response Relationship, Drug; Eating; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
THIP inhibits feeding behavior in fasted rats.
Topics: Animals; Dextroamphetamine; Dose-Response Relationship, Drug; Eating; Food Deprivation; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Central cardiovascular effects produced by the GABA receptor agonist drug, THIP.
Topics: Animals; Autonomic Nervous System; Bicuculline; Blood Pressure; Brain; Cats; Dose-Response Relationship, Drug; Female; Heart; Heart Rate; Injections, Intraventricular; Isoxazoles; Male; Oxazoles; Receptors, Cell Surface; Receptors, GABA-A | 1982 |
Glycine antagonists structurally related to muscimol, THIP, or isoguvacine.
Topics: Animals; Cats; gamma-Aminobutyric Acid; Glycine; Interneurons; Isonicotinic Acids; Isoxazoles; Muscimol; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Receptors, Glycine; Spinal Cord; Structure-Activity Relationship | 1982 |
Further characterization of the anorexic action of orally-administered THIP, a GABA-analogue, in the rat.
Topics: Administration, Oral; Animals; Bicuculline; Eating; gamma-Aminobutyric Acid; Isoxazoles; Male; Oxazoles; Pentylenetetrazole; Picrotoxin; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Strychnine | 1982 |
The acute effect of the GABA-agonist, THIP, on proprioceptive and flexor reflexes in spastic patients.
Topics: Adult; Female; Humans; Isoxazoles; Male; Mechanoreceptors; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Oxazoles; Paraplegia; Proprioception; Reaction Time; Receptors, Cell Surface; Receptors, GABA-A; Reflex, Monosynaptic; Reflex, Stretch | 1983 |
4,5,6,7-Tetrahydroisothiazolo[5,4-c]pyridin-3-ol and related analogues of THIP. Synthesis and biological activity.
Topics: Animals; Cats; Cerebral Cortex; gamma-Aminobutyric Acid; Isoxazoles; Oxazoles; Rats; Receptors, Cell Surface; Receptors, GABA-A; Synaptic Membranes | 1983 |
Diazepam stimulates the binding of GABA and muscimol but not THIP to rat brain membranes.
Topics: Analgesics; Animals; Brain; Diazepam; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Isoxazoles; Kinetics; Male; Muscimol; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A | 1983 |
Antinociceptive effect of the GABAmimetic 4,5,6,7-tetrahydroisoxazolo [5, 4-c]pyridin-3-ol (THIP): chronic treatment increases alpha-2 adrenoceptors in the mouse brain.
Topics: Analgesics; Animals; Brain Chemistry; Clonidine; Drug Tolerance; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Receptors, Adrenergic, alpha; Receptors, Cell Surface; Receptors, GABA-A | 1984 |
Microiontophoretically applied THIP effects upon nociceptive responses of neurons in medial thalamus.
Topics: Animals; Evoked Potentials; gamma-Aminobutyric Acid; Isoxazoles; Male; Morphine; Neurons; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Receptors, Cell Surface; Receptors, GABA-A; Spinothalamic Tracts; Synaptic Transmission; Tail; Thalamic Nuclei | 1983 |
Effects of THIP on chronic anxiety.
Topics: Adult; Anxiety Disorders; Female; Humans; Isoxazoles; Male; Middle Aged; Oxazoles; Psychiatric Status Rating Scales | 1983 |
Synthesis and antibacterial activity of triazole and isoxazole derivatives of ampicillin.
Topics: Ampicillin; Anti-Bacterial Agents; Bacteria; Indicators and Reagents; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles; Pseudomonas aeruginosa; Spectrophotometry, Infrared; Structure-Activity Relationship; Triazoles | 1983 |
Methylphenidate, apomorphine, THIP, and diazepam in monkeys: dopamine-GABA behavior related to psychoses and tardive dyskinesia.
Topics: Animals; Apomorphine; Chlorocebus aethiops; Diazepam; Dopamine; Drug Interactions; Dyskinesia, Drug-Induced; Female; gamma-Aminobutyric Acid; Hallucinations; Humans; Isoxazoles; Male; Methylphenidate; Motor Activity; Oxazoles; Psychoses, Substance-Induced | 1984 |
Substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acids: high-ceiling diuretics with uricosuric activity.
Topics: Animals; Chlorides; Diuretics; Dogs; Dose-Response Relationship, Drug; Furans; Haplorhini; Isoxazoles; Mice; Models, Molecular; Natriuresis; Oxazoles; Potassium; Rats; Sodium; Stereoisomerism; Structure-Activity Relationship; Uricosuric Agents | 1984 |
Acivicin: a new glutamine antagonist in clinical trials.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Drug Evaluation; Female; Glutamine; Half-Life; Humans; Isoxazoles; Kinetics; Leukemia, Experimental; Liver Neoplasms, Experimental; Macaca mulatta; Male; Mice; Neoplasms; Oxazoles; Purines; Pyrimidines; Sarcoma, Experimental | 1984 |
Benzisoxazolones: antimicrobial and antileukemic activity.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Antifungal Agents; Isoxazoles; Leukemia L1210; Oxazoles | 1984 |
The carboxyl group in the active center of transketolase.
Topics: Animals; Binding Sites; Carbodiimides; Ethyldimethylaminopropyl Carbodiimide; Hydrogen-Ion Concentration; Indicators and Reagents; Isoxazoles; Kinetics; Muscles; Oxazoles; Rabbits; Spectrophotometry, Ultraviolet; Transketolase | 1984 |
Phase II study of acivicin in colorectal carcinoma: a National Cancer Institute of Canada study.
Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System Diseases; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Hematologic Diseases; Humans; Infusions, Parenteral; Isoxazoles; Male; Middle Aged; Oxazoles; Rectal Neoplasms | 1984 |
[Synthesis and biological properties of isoxazolo[5,4-d]pyrimidine derivatives].
Topics: Animals; Anti-Inflammatory Agents; Central Nervous System; Chemical Phenomena; Chemistry; Humans; Isoxazoles; Oxazoles; Pyrimidines | 1984 |
Nonlinear pharmacokinetics of CI-912 in adult epileptic patients.
Topics: Adult; Anticonvulsants; Epilepsy; Female; Humans; Isoxazoles; Kinetics; Male; Middle Aged; Oxazoles; Pilot Projects; Zonisamide | 1984 |
Phase I evaluation of AT-125 single dose every three weeks.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System; Drug Administration Schedule; Drug Evaluation; Glutamine; Humans; Isoxazoles; Middle Aged; Neoplasms; Oxazoles | 1984 |
Effects of intrathecally administered THIP, baclofen and muscimol on nociceptive threshold.
Topics: Animals; Baclofen; Injections, Spinal; Isoxazoles; Male; Muscimol; Muscle Hypotonia; Nociceptors; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time; Sensory Thresholds | 1984 |
A new antibiotic Y-T0678H produced by a Chromobacterium species.
Topics: Anti-Bacterial Agents; Bacteria; Chromobacterium; Fermentation; Isoxazoles; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Oxazoles | 1983 |
Inhibitory action of 2-(1-,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284) on acetylcholine release from vagus nerve in guinea pig ileum.
Topics: Acetylcholine; Animals; Choline; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Isoxazoles; Male; Muscle Contraction; Muscle, Smooth; Oxazoles; Tetrodotoxin; Vagus Nerve; Vas Deferens | 1983 |
Unilateral injection of GABA agonists in the superior colliculus: asymmetry to tactile stimulation.
Topics: Analgesics; Animals; Baclofen; Functional Laterality; gamma-Aminobutyric Acid; Isoxazoles; Motor Activity; Muscimol; Oxazoles; Physical Stimulation; Rats; Rats, Inbred Strains; Superior Colliculi; Touch | 1983 |
Anorexic and analgesic actions of THIP.
Topics: Analgesics; Animals; Appetite Depressants; Behavior, Animal; Benzoquinones; Drug Interactions; Feeding Behavior; Isoxazoles; Male; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time | 1983 |
The analgesic effect of the GABA-agonist THIP in patients with chronic pain of malignant origin. A phase-1-2 study.
Topics: Adult; Aged; Analgesics; Analysis of Variance; Chronic Disease; Drug Evaluation; Female; Humans; Isoxazoles; Male; Middle Aged; Neoplasms; Oxazoles; Pain | 1983 |
Pharmacokinetics of the gamma-aminobutyric acid agonist THIP (Gaboxadol) following intramuscular administration to man, with observations in dog.
Topics: Absorption; Adult; Animals; Dogs; Humans; Injections, Intramuscular; Isoxazoles; Kinetics; Male; Models, Biological; Oxazoles | 1983 |
Comparison of the analgesic actions of THIP and morphine.
Topics: Analgesics; Animals; Atropine; Benzoquinones; Bicuculline; Hypnotics and Sedatives; Isoxazoles; Male; Mice; Morphine; Naloxone; Oxazoles; Quinones; Reaction Time | 1983 |
[3-substituted derivatives of 5-methylisoxazole with antiparasitic effects].
Topics: Animals; Anthelmintics; Antifungal Agents; Chemical Phenomena; Chemistry; Helminths; Isoxazoles; Oxazoles | 1983 |
Induction of mouse-killing in the rat by intraventricular injection of a GABA-agonist.
Topics: Aggression; Animals; Arousal; Bicuculline; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Humans; Injections, Intraventricular; Isoxazoles; Male; Motor Activity; Oxazoles; Rats; Rats, Inbred Strains; Reaction Time | 1983 |
State of DA/ACh balance after chronic treatment with haloperidol and with THIP in rats.
Topics: Acetylcholine; Animals; Apomorphine; Atropine; Behavior, Animal; Brain; Dopamine; Haloperidol; Isoxazoles; Male; Oxazoles; Physostigmine; Rats; Rats, Inbred Strains | 1984 |
Diazepam enhances the action but not the binding of the GABA analog, THIP.
Topics: Animals; Brain; Chlorides; Culture Techniques; Diazepam; Dose-Response Relationship, Drug; Drug Synergism; Ganglia, Spinal; Isoxazoles; Membrane Potentials; Mice; Oxazoles; Rats; Spinal Cord | 1984 |
Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole.
Topics: Antibiotics, Antineoplastic; Cell Cycle; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Humans; Isoxazoles; Kinetics; Oxazoles; Ribonucleosides; Ribonucleotides | 1984 |
Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
Topics: Animals; Anticonvulsants; Electroencephalography; gamma-Aminobutyric Acid; Haplorhini; Isoxazoles; Mice; Mice, Inbred DBA; Myoclonus; Oxazoles; Papio; Photic Stimulation; Seizures; Time Factors | 1980 |
Isoxazolidine-3,5-diones as lens aldose reductase inhibitors.
Topics: Aldehyde Reductase; Animals; Chemical Phenomena; Chemistry; In Vitro Techniques; Isoxazoles; Kinetics; Lens, Crystalline; Oxazoles; Rats; Sugar Alcohol Dehydrogenases | 1982 |
Collateral sensitivity to N-(phosphonacetyl)-L-aspartic acid in a line of P388 leukemia cells selected for resistance to L-(alpha S, 5S)-alpha-amino-3- chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
Topics: Adenine Phosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Ammonia); Drug Resistance; Hypoxanthine Phosphoribosyltransferase; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred Strains; Organophosphorus Compounds; Oxazoles; Phosphonoacetic Acid; Purines; Pyrimidines | 1983 |
Effects of acivicin and dipyridamole on hepatoma 3924A cells.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Deoxycytidine; Dipyridamole; Isoxazoles; Kinetics; Liver Neoplasms, Experimental; Oxazoles; Rats; Ribonucleosides | 1983 |
Analgesic, respiratory and endocrine responses in normal man to THIP, a GABA-agonist.
Topics: Adult; Analgesics; Dental Pulp Test; Double-Blind Method; Hormones; Humans; Hydrocortisone; Isoxazoles; Male; Oxazoles; Pain; Prolactin; Random Allocation; Respiration; Sensory Thresholds | 1983 |
THIP analgesia: cross tolerance with morphine.
Topics: Analgesia; Animals; Dose-Response Relationship, Drug; Drug Tolerance; Isoxazoles; Male; Mice; Models, Biological; Morphine; Nipecotic Acids; Oxazoles; Pyrones | 1983 |
Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO.
Topics: 4-Aminobutyrate Transaminase; Animals; Animals, Newborn; Anticonvulsants; Chickens; Cyclohexanecarboxylic Acids; Isoniazid; Isoxazoles; Male; Mice; Oxazoles; Seizures; Transaminases | 1983 |
A new antibiotic, 3,6-dihydroxyindoxazene.
Topics: Anti-Bacterial Agents; Chromobacterium; Isoxazoles; Oxazoles; X-Ray Diffraction | 1983 |
A comparison of the analgesic activities of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP) and 6-chloro-2[1-piperazinyl]pyrazine (MK 212).
Topics: Analgesics; Animals; Bicuculline; Dose-Response Relationship, Drug; Drug Synergism; Drug Tolerance; Isoxazoles; Male; Mice; Morphine; Oxazoles; Pyrazines; Time Factors | 1983 |
Quantitative determination of the gamma-aminobutyric acid agonist, 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol, in serum by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Dogs; gamma-Aminobutyric Acid; Humans; Isoxazoles; Kinetics; Oxazoles; Papio; Rats; Spectrophotometry, Ultraviolet | 1983 |
Combined action of acivicin and D-galactosamine on pyrimidine nucleotide metabolism in hepatoma cells.
Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Interactions; Female; Galactosamine; In Vitro Techniques; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Pyrimidine Nucleotides; Rats; Rats, Inbred Strains | 1983 |
Phase II trial of acivicin in advanced metastatic breast cancer.
Topics: Adult; Breast Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles | 1983 |
Heterocyclic oxyacetic acid diuretics: indazole, benzisothiazole, and benzisothiazole 1,1-dioxide analogues of [[7-chloro-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl]oxy]acetic acid.
Topics: Animals; Diuretics; Dogs; Isoxazoles; Mice; Natriuresis; Oxazoles | 1983 |
Pharmacokinetic studies of AD-810, a new antiepileptic compound. Phase I trials.
Topics: Adult; Anticonvulsants; Drug Evaluation; Electroencephalography; Erythrocytes; Humans; Isoxazoles; Kinetics; Male; Middle Aged; Oxazoles; Time Factors; Zonisamide | 1982 |
Inhibitory effects of aminoglutethimide and isoxazole on progesterone production and deciduoma formation in rats.
Topics: 3-Hydroxysteroid Dehydrogenases; Aminoglutethimide; Animals; Decidua; Female; Isoxazoles; Kinetics; Organ Size; Ovary; Oxazoles; Pregnancy; Progesterone; Rats; Steroids; Sterols; Uterus | 1980 |
[2-alkylaminomethyl-benzoisoxazolin-3-ones].
Topics: Animals; Antinematodal Agents; Antitrichomonal Agents; Chemical Phenomena; Chemistry; Depression; Drug Evaluation, Preclinical; Humans; Isoxazoles; Mice; Morpholines; Nematoda; Oxazoles; Piperazines; Piperidines; Trichomonas vaginalis | 1981 |
Stability of the isoxazolyl penicillins to staphylococcal beta-lactamase.
Topics: beta-Lactamases; Drug Stability; Isoxazoles; Oxazoles; Penicillins; Staphylococcus aureus | 1982 |
Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
Topics: Anthranilate Synthase; Binding, Competitive; Glutamate Synthase; Glutamine; Glycine; Isoxazoles; Kinetics; Nitrogenous Group Transferases; Oxazoles; Serratia marcescens; Transferases | 1980 |
Comparison of the carotenoid bandshift and oxanol dyes to measure membrane potential changes during chemotactic stimulation of Rhodopseudomonas sphaeroides and Escherichia coli.
Topics: Carotenoids; Chemotaxis; Coloring Agents; Escherichia coli; Isoxazoles; Membrane Potentials; Oxazoles; Rhodobacter sphaeroides; Spectrophotometry | 1981 |
Modification of the essential amino acids of human pancreatic carboxylic-ester hydrolase.
Topics: Carboxylesterase; Carboxylic Ester Hydrolases; Diethyl Pyrocarbonate; Formates; Histidine; Humans; Indicators and Reagents; Isoxazoles; Kinetics; Organophosphorus Compounds; Oxazoles; Pancreas | 1982 |
Catalytic properties of modified human pancreatic carboxylic-ester hydrolase.
Topics: Binding Sites; Carboxylesterase; Carboxylic Ester Hydrolases; Diethyl Pyrocarbonate; Glass; Humans; Indicators and Reagents; Isoxazoles; Kinetics; Organophosphorus Compounds; Oxazoles; Pancreas; Protein Binding | 1982 |
Determination of the gamma-aminobutyric acid agonist 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-3-ol in urine by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Humans; Isoxazoles; Kinetics; Oxazoles; Rats | 1982 |
Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma.
Topics: Amidophosphoribosyltransferase; Animals; Antimetabolites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Nucleotides; Oxazoles; Pentosyltransferases; Phenotype; Rats; Rats, Inbred ACI | 1982 |
In vivo inactivation by acivicin of carbamoyl-phosphate synthetase II in rat hepatoma.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); In Vitro Techniques; Isoxazoles; Kinetics; Ligases; Liver; Liver Neoplasms, Experimental; Magnesium; Male; Oxazoles; Rats; Rats, Inbred ACI | 1982 |
Plasma and cerebrospinal fluid pharmacokinetics of acivicin in Ommaya reservoir-bearing rhesus monkeys.
Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Half-Life; Isoxazoles; Kinetics; Macaca mulatta; Male; Methods; Models, Biological; Oxazoles | 1982 |
Isoxicam and related 4-hydroxy-N-isoxazolyl-2H-1,2-benzothiazine-3-carboxamide 1,1-dioxides. Potent nonsteroidal antiinflammatory agents.
Topics: Animals; Anti-Inflammatory Agents; Isoxazoles; Male; Oxazoles; Piroxicam; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Thiazines | 1982 |
[(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series.
Topics: Animals; Diuretics; Dogs; Isoxazoles; Male; Mice; Oxazoles; Structure-Activity Relationship; Uricosuric Agents | 1982 |
Effects of the putative GABAergic agonists, muscimol and THIP, upon local cerebral glucose utilisation.
Topics: Analgesics; Animals; Brain; Deoxy Sugars; Deoxyglucose; gamma-Aminobutyric Acid; Glycolysis; Isoxazoles; Male; Muscimol; Organ Specificity; Oxazoles; Rats; Rats, Inbred Strains | 1982 |
Phase I and pharmacological study of acivicin by 24-hour continuous infusion.
Topics: Antimetabolites; Digestive System; Drug Evaluation; Humans; Infusions, Parenteral; Isoxazoles; Kinetics; Neoplasms; Nervous System; Oxazoles | 1982 |
Effects of acivicin and PALA, singly and in combination, on de novo pyrimidine biosynthesis.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line; Isoxazoles; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nucleic Acids; Organophosphorus Compounds; Orotic Acid; Oxazoles; Phosphonoacetic Acid; Pyrimidines | 1982 |
Differentiation of the analgesic effects of THIP and morphine using three mouse strains.
Topics: Analgesics; Animals; GABA Antagonists; Hot Temperature; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles | 1982 |
Biochemical pharmacology of acivicin in rat hepatoma cells.
Topics: Animals; Carbon-Nitrogen Ligases; Cell Line; Cell Survival; Cytidine; Deoxycytidine; Deoxyribonucleotides; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Guanosine; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Oxazoles; Rats; Ribonucleotides | 1982 |
Synthesis and topical antiinflammatory activity of some steroidal [16 alpha, 17 alpha-d]Isoxazolidines.
Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Chemical Phenomena; Chemistry; Croton Oil; Glucocorticoids; Inflammation; Isoxazoles; Mice; Oxazoles | 1982 |
Comparison of the antinociceptive actions of THIP and morphine.
Topics: Analgesics; Animals; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; Injections, Intraperitoneal; Isoxazoles; Male; Mice; Mice, Inbred Strains; Morphine; Oxazoles; Reaction Time; Species Specificity | 1982 |
A possible mechanism of a new antispasmodic drug, 2-(1,2-benzisoxazol-3-yl)-3-[2-(2-piperidinoethoxy) phenyl]acrylonitrile (SX-284).
Topics: Animals; Cecum; Gastric Fundus; Gastrointestinal Motility; Guinea Pigs; Ileum; In Vitro Techniques; Isoxazoles; Male; Muscle Contraction; Muscle, Smooth; Oxazoles; Parasympatholytics; Phrenic Nerve; Trachea; Urinary Bladder | 1982 |
Antinociceptive and anticonvulsive effect of THIP, a pure GABA agonist.
Topics: Analgesics; Animals; Anticonvulsants; Benzoquinones; gamma-Aminobutyric Acid; Injections, Intraventricular; Isoxazoles; Mice; Morphine; Oxazoles; Quinones; Rats; Rats, Inbred Strains; Reaction Time | 1982 |
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Electroencephalographic profile.
Topics: Animals; Anticonvulsants; Arousal; Cats; Electroencephalography; Epilepsy; Female; Freezing; Hippocampus; Isoxazoles; Male; Oxazoles; Thalamus; Time Factors; Tungsten; Zonisamide | 1980 |
Analgesic properties of the GABA-mimetic THIP.
Topics: Analgesics; Animals; Arthritis, Experimental; Baclofen; Electric Stimulation; Isoxazoles; Macaca mulatta; Mice; Morphine; Muscimol; Oxazoles; Reaction Time | 1981 |
Sex- and age-related mouse toxicity and disposition of the amino acid antitumor agent, acivicin.
Topics: Age Factors; Animals; Antineoplastic Agents; Female; Glycine; Half-Life; Isoxazoles; Kinetics; Male; Metabolic Clearance Rate; Mice; Oxazoles; Sex Factors; Testosterone; Tissue Distribution | 1981 |
Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
Topics: Amidohydrolases; Animals; Asparagine; Azo Compounds; Cell Line; Diazooxonorleucine; DNA; Glutamine; Glycine; Isoxazoles; Kinetics; Leukemia L1210; Mice; Oxazoles; Temperature | 1981 |
Effects of 3-sulfamoylmethyl-1,2-benzisoxazole (AD-810) and some antiepileptics on the kindled seizures in the neocortex, hippocampus and amygdala in rats.
Topics: Amygdala; Animals; Anticonvulsants; Cerebral Cortex; Electric Stimulation; Electroencephalography; Hippocampus; Isoxazoles; Male; Oxazoles; Rats; Seizures; Zonisamide | 1981 |
Analytical studies on isoxazoles. II A new fluorimetric determination of 5-phenyl-3-isoxazolecarboxylic acid and its application to the determination of perisoxal in plasma.
Topics: Humans; Isoxazoles; Oxazoles; Piperidines; Spectrometry, Fluorescence | 1980 |
[The Hofmann reaction of 3-carbamoyl-5-methylisoxazole (author's transl)].
Topics: Isoxazoles; Oxazoles | 1981 |
Increases and decreases in local cerebral glucose utilization in response to GABA agonists.
Topics: Animals; Brain; gamma-Aminobutyric Acid; Glucose; Isoxazoles; Male; Muscimol; Oxazoles; Rats | 1981 |
The behavior of the fluorescence lifetime and polarization of oxonol potential-sensitive extrinsic probes in solution and in beef heart submitochondrial particles.
Topics: Adenosine Triphosphate; Alkenes; Animals; Cattle; Energy Metabolism; Ethanol; Fluorescence Polarization; Fluorescent Dyes; Isoxazoles; Magnesium; Magnesium Chloride; Mitochondria; Mitochondria, Heart; Oxazoles; Solutions; Submitochondrial Particles | 1981 |
Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid.
Topics: Animals; Aspartic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxycytosine Nucleotides; Deoxyribonucleosides; Drug Synergism; Glycine; Isoxazoles; Leukemia L1210; Mice; Organophosphorus Compounds; Orotic Acid; Oxazoles; Phosphonoacetic Acid; Pyrimidines; Ribonucleosides | 1981 |
Reaction of Woodward's Reagent K with pancreatic porcine phospholipase A2: modification of an essential carboxylase residue.
Topics: Animals; Benzenesulfonates; Binding Sites; Calcium; In Vitro Techniques; Isoxazoles; Models, Chemical; Oxazoles; Pancreas; Phospholipases; Phospholipases A; Phospholipases A2; Swine | 1981 |
Derivatization and purification of acivicin (AT-125, U-42,126).
Topics: Antibiotics, Antineoplastic; Antimetabolites; Glycine; Isoxazoles; Oxazoles | 1981 |
Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, Acivicin (NSC 163501).
Topics: Cell Count; Cell Division; Cell Line; Cell Survival; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Humans; Interphase; Isoxazoles; Kinetics; Male; Oxazoles; Pancreatic Neoplasms; Time Factors | 1981 |
Paradoxical blockade of a muscimol response by THIP, a GABA agonist and also by GABA-transaminase inhibitors.
Topics: 4-Aminobutyrate Transaminase; Animals; gamma-Aminobutyric Acid; Isoxazoles; Male; Mice; Muscimol; Myoclonus; Oxazoles; Time Factors; Transaminases | 1981 |
Single unit responses of substantia nigra and globus pallidus neurons to GABA agonist and antagonist drugs.
Topics: Animals; gamma-Aminobutyric Acid; Globus Pallidus; Iontophoresis; Isoxazoles; Kainic Acid; Male; Muscimol; Neurons; Oxazoles; Rats; Rats, Inbred Strains; Substantia Nigra | 1981 |
Preliminary studies on the absorption, distribution, metabolism, and excretion of THIP in animal and man using 14C-labelled compound.
Topics: Absorption; Adult; Animals; Brain; Carbon Radioisotopes; Chromatography, Thin Layer; Half-Life; Humans; Hydrolysis; Isoxazoles; Male; Mice; Mice, Inbred Strains; Middle Aged; Oxazoles; Rats; Rats, Inbred Strains; Tissue Distribution | 1981 |
Isolation of perisoxal glucuronides and determination of enantiomeric ratios of d-and l-perisoxal metabolites excreted in rabbit urine.
Topics: Animals; Glucuronates; Isoxazoles; Male; Oxazoles; Piperidines; Rabbits; Stereoisomerism | 1981 |
Synthesis and biological properties of 5-benzoylamino-3-methyl-4-isoxazolocarboxylic acid derivatives.
Topics: Anti-Inflammatory Agents; Isoxazoles; Oxazoles; Structure-Activity Relationship | 1981 |
Effects of 3-methyl-5-isoxazole carboxylic acid on the plasma volume loss induced by thermal trauma.
Topics: Animals; Blood Pressure; Burns; Cardiac Output; Dogs; Hematocrit; Isoxazoles; Nicotinic Acids; Oxazoles; Plasma Volume; Time Factors | 1980 |
Modification of the carboxypeptidase A active site residue Glu-270 prevents interaction with a protein protease inhibitor from Ascaris.
Topics: Animals; Ascaris; Benzenesulfonates; Binding Sites; Carboxypeptidases; Carboxypeptidases A; Glutamates; Hydrogen-Ion Concentration; Isoxazoles; Oxazoles; Protease Inhibitors; Protein Binding; Structure-Activity Relationship; Tetranitromethane; Tyrosine | 1980 |
3-Sulfamoylmethyl-1,2-benzisoxazole, a new type of anticonvulsant drug. Pharmacological profile.
Topics: Animals; Anticonvulsants; Barbiturates; Carbonic Anhydrase Inhibitors; Dogs; Electroshock; Isoxazoles; Motor Activity; Oxazoles; Rabbits; Rats; Seizures; Sleep; Species Specificity; Time Factors; Zonisamide | 1980 |
Oxonol-V as a probe of chromaffin granule membrane potentials.
Topics: Absorption; Alkenes; Animals; Biological Transport, Active; Cattle; Chromaffin Granules; Chromaffin System; Fluorescent Dyes; In Vitro Techniques; Isoxazoles; Membrane Potentials; Norepinephrine; Oxazoles | 1980 |
GABAergic actions of THIP in vivo and vitro: a comparison with muscimol and GABA.
Topics: Animals; Binding Sites; Brain; Cerebellum; Dose-Response Relationship, Drug; gamma-Aminobutyric Acid; In Vitro Techniques; Iontophoresis; Isoxazoles; Male; Muscimol; Neurons; Oxazoles; Rats; Substantia Nigra | 1980 |
Determination of perisoxal and its phenolic metabolites in rat, rabbit and human urine.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Biotransformation; Female; Humans; Isoxazoles; Oxazoles; Phenols; Piperidines; Rabbits; Rats; Species Specificity | 1980 |
Identification of canine urinary metabolites of the antiprotozoal agent 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole .
Topics: Animals; Antiprotozoal Agents; Chromatography, Gas; Chromatography, High Pressure Liquid; Dogs; Gas Chromatography-Mass Spectrometry; Isoxazoles; Magnetic Resonance Spectroscopy; Nitroimidazoles; Oxazoles | 1980 |
Therapeutic effects of acivicin and N-(phosphonacetyl)-L-aspartic acid in a biochemically designed trial against a N-(phosphonacetyl)-L-aspartic acid-resistant variant of the Lewis lung carcinoma.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carcinoma; Drug Therapy, Combination; Glycine; Isoxazoles; Ligases; Lung Neoplasms; Neoplasms, Experimental; Organophosphorus Compounds; Oxazoles; Phosphonoacetic Acid; Pyrimidines; Rats | 1981 |
The chemistry of pseudomonic acid. Part 14. Synthesis and in vivo biological activity of heterocyclyl substituted oxazole derivatives.
Topics: Animals; Anti-Bacterial Agents; Furans; Humans; Isoxazoles; Mice; Mupirocin; Oxazoles; Pyrazoles; Pyridines; Sepsis; Staphylococcal Infections; Thiazoles; Thiophenes | 1995 |
Isoxazolidine-3,5-dione and noncyclic 1,3-dicarbonyl compounds as hypoglycemic agents.
Topics: 3T3 Cells; Animals; Blood Glucose; Cell Differentiation; Drug Evaluation, Preclinical; Hypoglycemic Agents; Insulin; Isoxazoles; L Cells; Male; Malonates; Mice; Oxazoles; Triglycerides | 1998 |
Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.
Topics: Binding Sites; Estradiol; Estrogen Antagonists; Estrogens; Imidazoles; Isoxazoles; Ligands; Models, Molecular; Oxazoles; Piperidines; Protein Conformation; Pyrazoles; Raloxifene Hydrochloride; Receptors, Estrogen; Thiazoles; X-Ray Diffraction | 1999 |
Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles.
Topics: Anti-Bacterial Agents; Gram-Positive Bacteria; Isoxazoles; Microbial Sensitivity Tests; Oxazoles | 1999 |
Analysis of three structurally related antiviral compounds in complex with human rhinovirus 16.
Topics: Antiviral Agents; Binding Sites; Crystallography; Isoxazoles; Models, Molecular; Oxazoles; Rhinovirus; Structure-Activity Relationship; Tetrazoles | 1999 |
Comparative in vitro efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet-mediated clot strength induced by tissue factor with use of thromboelastography: differentiation among glycoprotein IIb/IIIa antagonists.
Topics: Abciximab; Alanine; Amidines; Antibodies, Monoclonal; Blood Coagulation; Blood Platelets; Elasticity; Fibrin; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Nephelometry and Turbidimetry; Oxazoles; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Platelet Glycoprotein GPIIb-IIIa Complex; Recombinant Proteins; Sulfonamides; Thrombelastography; Thromboplastin; Viscosity | 2000 |
In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses.
Topics: Antiviral Agents; Cell Survival; Cells, Cultured; Common Cold; Humans; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Reverse Transcriptase Polymerase Chain Reaction; Rhinovirus; Spectrophotometry; Valine | 2000 |
Biphenylsulfonamide endothelin receptor antagonists. 4. Discovery of N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]- 2-yl]methyl]-N,3,3-trimethylbutanamide (BMS-207940), a highly potent and orally active ET(A) selective
Topics: Administration, Oral; Animals; Blood Pressure; Caco-2 Cells; Carotid Arteries; CHO Cells; Cricetinae; Endothelin Receptor Antagonists; Humans; In Vitro Techniques; Isoxazoles; Macaca fascicularis; Male; Muscle Contraction; Oxazoles; Rabbits; Rats; Rats, Sprague-Dawley; Receptor, Endothelin A; Receptor, Endothelin B; Structure-Activity Relationship; Sulfonamides | 2003 |
Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes.
Topics: Air; Amidines; Animals; Carbon Monoxide; Chemistry Techniques, Analytical; Cytochrome P-450 Enzyme System; Electrons; Indoles; Isoxazoles; Ketoconazole; Microsomes, Liver; Molecular Structure; NADP; Oxazoles; Oxidation-Reduction; Rats; Structure-Activity Relationship | 2003 |
[Condensation of isonicotinic & cyanacetic acid hydrazides with several isoxazole ketones. II].
Topics: Hydrazines; Isoniazid; Isoxazoles; Ketones; Oxazoles | 1958 |
SYNERGISM OF D-4-AMINO-3-ISOXAZOLIDONE AND O-CARBAMYL-D-SERINE.
Topics: Anti-Bacterial Agents; Bacillus subtilis; Isoxazoles; Mycobacterium; Mycobacterium tuberculosis; Oxazoles; Oxazolidinones; Pharmacology; Research; Serine; Staphylococcus | 1964 |
STEROIDAL HETEROCYCLES. VII. ANDROSTANO(2,3-D)ISOXAZOLES AND RELATED COMPOUNDS.
Topics: Anabolic Agents; Castration; Chemistry, Pharmaceutical; Isoxazoles; Muscles; Oxazoles; Pharmacology; Rats; Research; Steroids | 1963 |
[REACTIVITY OF DICARBONYL-ISOXAZOLES. VI. TRANSFORMATION OF 3-CARBONYL-ISOXAZOLE OXIMES INTO FURAZAN DERIVATIVES].
Topics: Chemistry, Pharmaceutical; Isoxazoles; Oxadiazoles; Oxazoles; Oximes; Pharmacy; Research | 1964 |
ISOXAZOLES. XVI. THE REACTION OF NITROUS ACID ON 5-AMINO-3,4-DIALKYLISOXAZOLES.
Topics: Chemistry, Pharmaceutical; Isoxazoles; Nitrites; Nitrous Acid; Oxazoles; Research | 1964 |
[A DERIVATIVE OF ISOXAZOLE. I. ON REACTIONS BETWEEN DIKETENE AND HYDROXYLAMINE OR SOME HYDROXAMIC ACIDS].
Topics: Chemistry, Pharmaceutical; Hydroxamic Acids; Hydroxylamine; Hydroxylamines; Isoxazoles; Ketones; Lactones; Oxazoles; Research | 1965 |
Human rhinovirus capsid dynamics is controlled by canyon flexibility.
Topics: Antibodies, Viral; Antigen-Antibody Reactions; Binding Sites; Capsid; HeLa Cells; Humans; Immunoglobulin Fab Fragments; Isoxazoles; Microscopy, Electron; Models, Molecular; Mutation; Oxadiazoles; Oxazoles; Rhinovirus; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Virus Assembly | 2003 |
COX-2/VEGF-dependent facilitation of tumor-associated angiogenesis and tumor growth in vivo.
Topics: Animals; Antibodies, Blocking; Aspirin; Benzenesulfonates; Carcinoma, Lewis Lung; Cyclooxygenase Inhibitors; Disease Models, Animal; Endothelial Growth Factors; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lymphokines; Male; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neovascularization, Pathologic; Nitrobenzenes; Oxazoles; Prostaglandin-Endoperoxide Synthases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sarcoma 180; Sulfonamides; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors | 2003 |
Synthesis and microbial inhibition study of novel 5-imidazolyl substituted isoxazolidines.
Topics: Anti-Bacterial Agents; Antifungal Agents; Gram-Negative Bacteria; Gram-Positive Bacteria; Isoxazoles; Mitosporic Fungi; Oxazoles; Structure-Activity Relationship | 2004 |
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole.
Topics: Dipeptidyl Peptidase 4; Isoxazoles; Oxazoles; Piperidines; Protease Inhibitors; Pyrazoles; Thiazoles | 2005 |
Tricyclic isoxazolines: identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and alpha2-adrenoceptor antagonism.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antidepressive Agents, Tricyclic; Humans; Isoxazoles; Male; Oxazoles; Pyrazines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors | 2007 |
Synthesis of natural product-inspired inhibitors of Mycobacterium tuberculosis mycothiol-associated enzymes: the first inhibitors of GlcNAc-Ins deacetylase.
Topics: Amidohydrolases; Bacterial Proteins; Binding Sites; Cysteine; Furans; Glycopeptides; Inositol; Isoxazoles; Models, Molecular; Mycobacterium tuberculosis; Oxazines; Oxazoles; Protein Binding; Pyrans; Stereoisomerism; Sulfonamides; Thioglycosides | 2007 |
3-amino-benzo[d]isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antineoplastic Agents; Binding Sites; Biological Availability; Capillary Permeability; Cell Line; Cell Line, Tumor; Edema; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Models, Molecular; NIH 3T3 Cells; Oxazoles; Phenylurea Compounds; Phosphorylation; Receptors, Platelet-Derived Growth Factor; Receptors, Vascular Endothelial Growth Factor; Structure-Activity Relationship; Uterus; Xenograft Model Antitumor Assays | 2008 |
New pleconaril and [(biphenyloxy)propyl]isoxazole derivatives with substitutions in the central ring exhibit antiviral activity against pleconaril-resistant coxsackievirus B3.
Topics: Antiviral Agents; Drug Design; Drug Resistance, Viral; Enterovirus B, Human; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Mutation; Oxadiazoles; Oxazoles | 2009 |
The versatile electrophilic reactivity of 4,6-dinitrobenzo[d]isoxazole-3-carbonitrile.
Topics: Dimethyl Sulfoxide; Isoxazoles; Kinetics; Methanol; Molecular Structure; Nitriles; Oxazoles; Stereoisomerism; Thermodynamics | 2009 |
The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds.
Topics: Aldehyde Dehydrogenase; Bacterial Proteins; Isomerism; Isoxazoles; Oxazoles; Staphylococcus aureus | 2010 |
Synthesis of a novel human PPARδ selective agonist and its stimulatory effect on oligodendrocyte differentiation.
Topics: Animals; Brain; Cell Differentiation; Humans; Isoxazoles; Multiple Sclerosis; Oligodendroglia; Oxazoles; PPAR delta; Rats; Transcriptional Activation | 2011 |
Photochemistry and vibrational spectra of matrix-isolated methyl 4-chloro-5-phenylisoxazole-3-carboxylate.
Topics: Argon; Computer Simulation; Energy Transfer; Isoxazoles; Models, Molecular; Molecular Conformation; Molecular Structure; Oxazoles; Photochemistry; Quantum Theory; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Temperature; Thermodynamics; Ultraviolet Rays; Vibration; Xenon | 2011 |
Microwave-promoted synthesis of 3-amino-substituted 1,2-benzisoxazoles.
Topics: Amines; Anticonvulsants; Antipsychotic Agents; Benzoxazoles; Isoxazoles; Microwaves; Oxazoles; Time Factors | 2010 |
Synthesis and antioxidant activity of oxazolyl/thiazolylsulfonylmethyl pyrazoles and isoxazoles.
Topics: Antioxidants; Biphenyl Compounds; Free Radicals; Isoxazoles; Nitric Oxide; Oxazoles; Picrates; Pyrazoles; Thiazoles | 2011 |
Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds.
Topics: Antitubercular Agents; Isomerism; Isoxazoles; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Oxazoles; Pyridines; Structure-Activity Relationship; Thiazoles | 2012 |
Trade-offs in defensive metabolite production but not ecological function in healthy and diseased sponges.
Topics: Animal Diseases; Animals; Anti-Bacterial Agents; Bacteria; Caribbean Region; Chromatography, High Pressure Liquid; Feeding Behavior; Isoxazoles; Oxazoles; Porifera; Spiro Compounds; Tetraodontiformes; Tyrosine | 2012 |
Capture of an elusive nitrile ylide as an intermediate in isoxazole-oxazole photoisomerization.
Topics: Isoxazoles; Molecular Structure; Nitriles; Oxazoles; Spectrophotometry, Ultraviolet; Stereoisomerism; Temperature; Ultraviolet Rays | 2013 |
Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C.
Topics: Antiviral Agents; Common Cold; Dose-Response Relationship, Drug; HeLa Cells; Humans; In Vitro Techniques; Isoxazoles; Oxadiazoles; Oxazoles; Phenylalanine; Piperidines; Pyridazines; Pyrrolidinones; Replicon; Rhinovirus; RNA, Viral; Tubercidin; Valine; Virus Replication | 2014 |
Effects of isoxazolo-pyridinone 7e, a potent activator of the Nurr1 signaling pathway, on experimental autoimmune encephalomyelitis in mice.
Topics: Animals; Axons; Cell Count; Demyelinating Diseases; Down-Regulation; Encephalomyelitis, Autoimmune, Experimental; Female; Isoxazoles; Macrophages; Mice, Inbred C57BL; Myelin-Oligodendrocyte Glycoprotein; NF-kappa B; Nuclear Receptor Subfamily 4, Group A, Member 2; Oxazoles; Peptide Fragments; Pyrimidinones; Signal Transduction; Spinal Cord; T-Lymphocytes | 2014 |
Epithelial-mesenchymal transition confers resistance to selective FGFR inhibitors in SNU-16 gastric cancer cells.
Topics: Antineoplastic Agents; Benzamides; Cell Line, Tumor; Drug Resistance, Neoplasm; Epithelial-Mesenchymal Transition; Humans; Isoxazoles; Molecular Targeted Therapy; Oxazoles; Phenylurea Compounds; Piperazines; Protein Kinase Inhibitors; Pyrazoles; Pyrimidines; Receptor, Fibroblast Growth Factor, Type 2; Receptors, Fibroblast Growth Factor; Resorcinols; Stomach Neoplasms; Transforming Growth Factor beta1; Triazoles | 2016 |
Isoxazole to oxazole: a mild and unexpected transformation.
Topics: Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Isoxazoles; Molecular Structure; Oxazoles | 2015 |
4,5-Substituted 3-Isoxazolols with Insecticidal Activity Act as Competitive Antagonists of Housefly GABA Receptors.
Topics: Animals; Binding, Competitive; GABA Antagonists; Gene Expression; Houseflies; Insecticides; Isoxazoles; Models, Molecular; Molecular Structure; Muscimol; Oocytes; Oxazoles; Receptors, GABA; Xenopus laevis | 2015 |
Mechanistic Analysis of an Isoxazole-Oxazole Photoisomerization Reaction Using a Conical Intersection.
Topics: Isoxazoles; Models, Chemical; Molecular Structure; Oxazoles; Photochemical Processes; Quantum Theory; Stereoisomerism | 2015 |
Strong deshielding in aromatic isoxazolines.
Topics: Acridines; Chlorobenzenes; Crystallography, X-Ray; Cyclization; Isoxazoles; Magnetic Resonance Spectroscopy; Molecular Structure; Nitriles; Oxazoles; Peptides, Cyclic; Stereoisomerism | 2016 |
Function-Oriented Synthesis: How to Design Simplified Analogues of Antibacterial Nucleoside Natural Products?
Topics: Anti-Bacterial Agents; Biological Products; Drug Design; Enterococcus; Isoxazoles; Microbial Sensitivity Tests; Nucleosides; Oxazoles; Staphylococcus aureus; Structure-Activity Relationship | 2016 |
Replacement of Oxygen by Sulfur in Small Organic Molecules. 3. Theoretical Studies on the Tautomeric Equilibria of the 2OH and 4OH-Substituted Oxazole and Thiazole and the 3OH and 4OH-Substituted Isoxazole and Isothiazole in the Isolated State and in Solu
Topics: Isomerism; Isoxazoles; Models, Theoretical; Oxazoles; Solutions; Sulfur; Thermodynamics; Thiazoles | 2016 |
Optimization of the choline transporter (CHT) inhibitor ML352: Development of VU6001221, an improved in vivo tool compound.
Topics: Animals; Benzamides; Dose-Response Relationship, Drug; Half-Life; Inhibitory Concentration 50; Isoxazoles; Membrane Transport Proteins; Oxazoles; Piperidines; Rats; Structure-Activity Relationship | 2016 |
Targeting Hsp90 with FS-108 circumvents gefitinib resistance in EGFR mutant non-small cell lung cancer cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Drug Resistance, Neoplasm; ErbB Receptors; Female; Gefitinib; Heterografts; HSP90 Heat-Shock Proteins; Humans; Isoxazoles; Lung Neoplasms; Mice, Inbred BALB C; Mice, Nude; Mutation; Neoplasm Transplantation; Oxazoles; Quinazolines; Resorcinols | 2016 |
Structure-Based Design of Tricyclic NF-κB Inducing Kinase (NIK) Inhibitors That Have High Selectivity over Phosphoinositide-3-kinase (PI3K).
Topics: Active Transport, Cell Nucleus; Animals; Binding Sites; Cell Nucleus; Dogs; HEK293 Cells; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Heterocyclic Compounds, Bridged-Ring; Humans; Imidazoles; Isoxazoles; Mice; NF-kappa B p50 Subunit; NF-kappa B p52 Subunit; NF-kappaB-Inducing Kinase; Oxazepines; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Signal Transduction | 2017 |
Simultaneous determination of parecoxib and its main metabolites valdecoxib and hydroxylated valdecoxib in mouse plasma with a sensitive LC-MS/MS method to elucidate the decreased drug metabolism of tumor bearing mice.
Topics: Animals; Cell Line, Tumor; Chromatography, High Pressure Liquid; Cyclooxygenase 2 Inhibitors; Cytochrome P-450 Enzyme System; Drug Monitoring; Female; Humans; Isoxazoles; Mice; Mice, Inbred BALB C; Neoplasms; Oxazoles; Prodrugs; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Sulfonamides; Tandem Mass Spectrometry; Xenograft Model Antitumor Assays | 2018 |
Automated cell-based luminescence assay for profiling antiviral compound activity against enteroviruses.
Topics: Animals; Antiviral Agents; Chlorocebus aethiops; Cytopathogenic Effect, Viral; Enterovirus; Enterovirus Infections; HeLa Cells; Humans; Isoxazoles; Luminescent Measurements; Microbial Sensitivity Tests; Oxadiazoles; Oxazoles; Phenylalanine; Pyrrolidinones; Valine; Vero Cells | 2019 |
Rational design, synthesis and structure-activity relationship of novel substituted oxazole isoxazole carboxamides as herbicide safener.
Topics: Acetolactate Synthase; Enzyme Activation; Glutathione; Glutathione Transferase; Herbicides; Isoxazoles; Oxazoles; Structure-Activity Relationship; Sulfonamides; Triazines; Zea mays | 2019 |
Synthesis of GluN2A-selective NMDA receptor antagonists with an electron-rich aromatic B-ring.
Topics: Allosteric Site; Animals; Electrons; Electrophysiological Phenomena; Humans; Isoxazoles; Ligands; Oocytes; Oxazoles; Protein Subunits; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Sulfonamides; Thiazoles; Xenopus laevis | 2021 |
The In Vitro Impact of Isoxazole Derivatives on Pathogenic Biofilm and Cytotoxicity of Fibroblast Cell Line.
Topics: Animals; Anti-Bacterial Agents; Anti-Infective Agents, Local; Biofilms; Cell Line; Fibroblasts; Isoxazoles; Microbial Sensitivity Tests; Oxazoles; Pseudomonas aeruginosa; Staphylococcus aureus | 2023 |