oxazoles has been researched along with indazoles in 18 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (11.11) | 18.7374 |
| 1990's | 1 (5.56) | 18.2507 |
| 2000's | 1 (5.56) | 29.6817 |
| 2010's | 11 (61.11) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Coupry, I; Lachaud, V; Limon, I; Parini, A; Tesson, F | 1 |
| Begany, AJ; Datko, SL; Dervinis, A; Gluckman, MI; Malis, JL; Rosenthale, ME; Shriver, DA | 1 |
| Bondavalli, F; Longobardi, M; Schenone, P | 1 |
| Fettinger, JC; Haddadin, MJ; Kurth, MJ; Oakdale, JS; Solano, DM | 1 |
| Crysler, C; Hou, C; Hufnagel, H; Johnson, D; McKenney, S; O'Neill, J; Opas, E; Sui, Z; Zhang, X | 1 |
| Conrad, WE; Fettinger, JC; Haddadin, MJ; Kurth, MJ; Nguyen, HH; Rodriguez, KX | 1 |
| Beall, HD; Bibby, JM; Hassani, M; Moody, CJ; Newsome, JJ; Swann, E | 1 |
| Buijsman, RC; de Man, J; de Roos, JA; de Vetter, JR; Prinsen, MB; Spijkers-Hagelstein, JA; Uitdehaag, JC; van Doornmalen, AM; Zaman, GJ | 1 |
| Amour, A; Baldwin, IR; Cooper, AW; Deakin, AM; Down, K; Felton, LM; Guntrip, SB; Hamblin, JN; Hardy, C; Harrison, ZA; Jones, KL; Jones, P; Keeling, SE; Le, J; Livia, S; Lucas, F; Lunniss, CJ; Parr, NJ; Robinson, E; Rowland, P; Smith, S; Thomas, DA; Vitulli, G; Washio, Y | 1 |
| Ammazzalorso, A; Amoroso, R; Carradori, S; De Filippis, B; Di Matteo, M; Fantacuzzi, M; Giampietro, L; Maccallini, C; Pandolfi, A; Supuran, CT; Vullo, D | 1 |
| Begg, M; Cahn, A; Dunsire, L; Fuhr, R; Galinanes-Garcia, L; Hamblin, JN; Hessel, EM; Kirsten, AM; Leemereise, CN; Montembault, M; Sriskantharajah, S; Watz, H; Wilson, R | 1 |
| Begg, M; Cahn, A; Cui, Y; Hamblin, JN; Hessel, EM; Hogg, A; Khindri, S; Kornmann, O; Leemereise, C; Ludwig-Sengpiel, A; Montembault, M; Robertson, J; Wajdner, H; Yang, S | 1 |
| Cahn, A; Igarashi, H; Ino, H; Numachi, Y; Ogura, H; Terao, T; Wilson, R | 1 |
| Ahmad, S; Amour, A; Begg, M; Boyce, M; Cahn, A; Clark, J; Cui, Y; Deans, A; Dear, G; Fantom, K; Green, J; Hamblin, JN; Hessel, EM; Kielkowska, A; Montembault, M; Wilson, R; Worsley, S | 1 |
| Banham-Hall, E; Cahn, A; Eames, R; Hessel, EM; Leemereise, C; Templeton, A; Wilson, R | 1 |
| Cahn, AP; Georgiou, A; Harrell, AW; Hessel, EM; Marotti, M; Patel, A; Riddell, K; Taskar, KS; Taylor, M; Tracey, H; Wilson, R | 1 |
| Cahn, A; Fahy, WA; Hessel, EM; Homayoun-Valiani, F; Lowings, M; Marotti, M; Meeraus, WH; Robertson, J; Tabberer, M; Templeton, A; West, SL; Wilson, R | 1 |
| Amour, A; Edwards, CD; Graves, RH; Harrell, AW; Hessel, EM; Miller, NA; O'Brien, B; Patel, A; Robb, O; Taylor, E | 1 |
7 trial(s) available for oxazoles and indazoles
| Article | Year |
|---|---|
Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD.
Topics: Administration, Inhalation; Aged; Class I Phosphatidylinositol 3-Kinases; Cytokines; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Piperazines; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Sputum; Treatment Outcome | 2017 |
A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma.
Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Asthma; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Phosphatidylinositol 3-Kinases; Piperazines; Vital Capacity; Young Adult | 2018 |
Evaluation of the Safety, Tolerability, and Pharmacokinetics of GSK2269557 (Nemiralisib) Administered Via Dry Powder Inhaler to Healthy Japanese Subjects.
Topics: Administration, Inhalation; Adult; Area Under Curve; Asian People; Double-Blind Method; Drug Administration Schedule; Dry Powder Inhalers; Healthy Volunteers; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Piperazines; Protein Kinase Inhibitors | 2019 |
Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib.
Topics: Adult; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Smokers; Sputum | 2019 |
Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals.
Topics: Administration, Inhalation; Double-Blind Method; Dry Powder Inhalers; Humans; Indazoles; Indoles; Oxazoles; Piperazines | 2019 |
Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.
Topics: Administration, Inhalation; Adolescent; Adult; Aged; Area Under Curve; Clarithromycin; Computer Simulation; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Erythromycin; Healthy Volunteers; Humans; Indazoles; Indoles; Itraconazole; Male; Microsomes, Liver; Midazolam; Middle Aged; Models, Biological; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Prospective Studies; Retrospective Studies; Young Adult | 2020 |
Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.
Topics: Bronchodilator Agents; Double-Blind Method; Forced Expiratory Volume; Humans; Indazoles; Indoles; Oxazoles; Phosphatidylinositol 3-Kinases; Piperazines; Pulmonary Disease, Chronic Obstructive | 2021 |
11 other study(ies) available for oxazoles and indazoles
| Article | Year |
|---|---|
Characterization of imidazoline-guanidinium receptive sites in renal medulla from human kidney.
Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Guanidine; Guanidines; Humans; Idazoxan; Imidazoline Receptors; Indazoles; Kidney Medulla; Oxazoles; Rabbits; Receptors, Adrenergic; Receptors, Cell Surface; Receptors, Drug; Tritium; Yohimbine | 1992 |
Anti-inflammatory properties of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin).
Topics: Airway Obstruction; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Bradykinin; Carrageenan; Dogs; Edema; Emulsions; Encephalomyelitis, Autoimmune, Experimental; Female; Fever; Freund's Adjuvant; Indazoles; Male; Molecular Weight; Mycobacterium; Oxazoles; Peptic Ulcer; Propionates; Rats; Sulfanilamides; Synovitis; Time Factors; Uric Acid; Yeasts | 1974 |
[Derivatives of 5-hydroxymethylen-cis-4-caranone].
Topics: Animals; Bridged-Ring Compounds; Central Nervous System; Drug Evaluation, Preclinical; Hydrogenation; Indazoles; Oxazoles; Pyrazoles; Spectrophotometry, Infrared | 1974 |
An oxazolo[3,2-b]indazole route to 1H-indazolones.
Topics: Alcohols; Benzylamines; Indazoles; Molecular Structure; Oxazoles | 2009 |
Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.
Topics: Animals; Cell Line; Cyclohexanes; Dogs; Drug Design; Humans; Indazoles; Oxazoles; Rats; Receptors, CCR2; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG | 2011 |
A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles.
Topics: Alkynes; Catalysis; Cyclization; Hydrocarbons, Brominated; Indazoles; Molecular Structure; Oxazoles; Palladium; Triazoles | 2012 |
Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
Topics: Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Enzyme Assays; Humans; Indazoles; NAD(P)H Dehydrogenase (Quinone); Oxazoles; Oxidation-Reduction; Quinones; Thiophenes | 2013 |
Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aza Compounds; Benzimidazoles; beta Catenin; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Indazoles; Indoles; Melanoma; Molecular Targeted Therapy; Mutation; Oxazoles; Oximes; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Quinolines; Sulfonamides; Triazoles; Vemurafenib | 2015 |
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
Topics: Administration, Inhalation; Animals; Asthma; Female; Humans; Indazoles; Indoles; Isoenzymes; Male; Microsomes; Molecular Docking Simulation; Ovalbumin; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rabbits; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Th2 Cells | 2015 |
Indazole, Pyrazole, and Oxazole Derivatives Targeting Nitric Oxide Synthases and Carbonic Anhydrases.
Topics: Carbonic Anhydrase I; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indazoles; Molecular Structure; Nitric Oxide Synthase Type I; Oxazoles; Pyrazoles; Structure-Activity Relationship | 2016 |
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
Topics: Absorption, Physiological; Administration, Inhalation; Administration, Oral; Animals; Computer Simulation; Humans; Indazoles; Indoles; Models, Biological; Oxazoles; Piperazines; Rats | 2022 |