Page last updated: 2024-08-21

oxazoles and indazoles

oxazoles has been researched along with indazoles in 18 studies

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19902 (11.11)18.7374
1990's1 (5.56)18.2507
2000's1 (5.56)29.6817
2010's11 (61.11)24.3611
2020's3 (16.67)2.80

Authors

AuthorsStudies
Coupry, I; Lachaud, V; Limon, I; Parini, A; Tesson, F1
Begany, AJ; Datko, SL; Dervinis, A; Gluckman, MI; Malis, JL; Rosenthale, ME; Shriver, DA1
Bondavalli, F; Longobardi, M; Schenone, P1
Fettinger, JC; Haddadin, MJ; Kurth, MJ; Oakdale, JS; Solano, DM1
Crysler, C; Hou, C; Hufnagel, H; Johnson, D; McKenney, S; O'Neill, J; Opas, E; Sui, Z; Zhang, X1
Conrad, WE; Fettinger, JC; Haddadin, MJ; Kurth, MJ; Nguyen, HH; Rodriguez, KX1
Beall, HD; Bibby, JM; Hassani, M; Moody, CJ; Newsome, JJ; Swann, E1
Buijsman, RC; de Man, J; de Roos, JA; de Vetter, JR; Prinsen, MB; Spijkers-Hagelstein, JA; Uitdehaag, JC; van Doornmalen, AM; Zaman, GJ1
Amour, A; Baldwin, IR; Cooper, AW; Deakin, AM; Down, K; Felton, LM; Guntrip, SB; Hamblin, JN; Hardy, C; Harrison, ZA; Jones, KL; Jones, P; Keeling, SE; Le, J; Livia, S; Lucas, F; Lunniss, CJ; Parr, NJ; Robinson, E; Rowland, P; Smith, S; Thomas, DA; Vitulli, G; Washio, Y1
Ammazzalorso, A; Amoroso, R; Carradori, S; De Filippis, B; Di Matteo, M; Fantacuzzi, M; Giampietro, L; Maccallini, C; Pandolfi, A; Supuran, CT; Vullo, D1
Begg, M; Cahn, A; Dunsire, L; Fuhr, R; Galinanes-Garcia, L; Hamblin, JN; Hessel, EM; Kirsten, AM; Leemereise, CN; Montembault, M; Sriskantharajah, S; Watz, H; Wilson, R1
Begg, M; Cahn, A; Cui, Y; Hamblin, JN; Hessel, EM; Hogg, A; Khindri, S; Kornmann, O; Leemereise, C; Ludwig-Sengpiel, A; Montembault, M; Robertson, J; Wajdner, H; Yang, S1
Cahn, A; Igarashi, H; Ino, H; Numachi, Y; Ogura, H; Terao, T; Wilson, R1
Ahmad, S; Amour, A; Begg, M; Boyce, M; Cahn, A; Clark, J; Cui, Y; Deans, A; Dear, G; Fantom, K; Green, J; Hamblin, JN; Hessel, EM; Kielkowska, A; Montembault, M; Wilson, R; Worsley, S1
Banham-Hall, E; Cahn, A; Eames, R; Hessel, EM; Leemereise, C; Templeton, A; Wilson, R1
Cahn, AP; Georgiou, A; Harrell, AW; Hessel, EM; Marotti, M; Patel, A; Riddell, K; Taskar, KS; Taylor, M; Tracey, H; Wilson, R1
Cahn, A; Fahy, WA; Hessel, EM; Homayoun-Valiani, F; Lowings, M; Marotti, M; Meeraus, WH; Robertson, J; Tabberer, M; Templeton, A; West, SL; Wilson, R1
Amour, A; Edwards, CD; Graves, RH; Harrell, AW; Hessel, EM; Miller, NA; O'Brien, B; Patel, A; Robb, O; Taylor, E1

Trials

7 trial(s) available for oxazoles and indazoles

ArticleYear
Safety, pharmacokinetics and dose-response characteristics of GSK2269557, an inhaled PI3Kδ inhibitor under development for the treatment of COPD.
    Pulmonary pharmacology & therapeutics, 2017, Volume: 46

    Topics: Administration, Inhalation; Aged; Class I Phosphatidylinositol 3-Kinases; Cytokines; Dose-Response Relationship, Drug; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Piperazines; Pulmonary Disease, Chronic Obstructive; Severity of Illness Index; Sputum; Treatment Outcome

2017
A Multicentre, Randomized, Double-Blind, Placebo-Controlled, Crossover Study To Investigate the Efficacy, Safety, Tolerability, and Pharmacokinetics of Repeat Doses of Inhaled Nemiralisib in Adults with Persistent, Uncontrolled Asthma.
    The Journal of pharmacology and experimental therapeutics, 2018, Volume: 367, Issue:3

    Topics: Administration, Inhalation; Adrenergic beta-2 Receptor Agonists; Adult; Aged; Asthma; Bronchodilator Agents; Cross-Over Studies; Double-Blind Method; Female; Forced Expiratory Volume; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Phosphatidylinositol 3-Kinases; Piperazines; Vital Capacity; Young Adult

2018
Evaluation of the Safety, Tolerability, and Pharmacokinetics of GSK2269557 (Nemiralisib) Administered Via Dry Powder Inhaler to Healthy Japanese Subjects.
    Clinical pharmacology in drug development, 2019, Volume: 8, Issue:1

    Topics: Administration, Inhalation; Adult; Area Under Curve; Asian People; Double-Blind Method; Drug Administration Schedule; Dry Powder Inhalers; Healthy Volunteers; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Piperazines; Protein Kinase Inhibitors

2019
Relationship between Pharmacokinetics and Pharmacodynamic Responses in Healthy Smokers Informs a Once-Daily Dosing Regimen for Nemiralisib.
    The Journal of pharmacology and experimental therapeutics, 2019, Volume: 369, Issue:3

    Topics: Adult; Bronchoalveolar Lavage Fluid; Dose-Response Relationship, Drug; Female; Healthy Volunteers; Humans; Indazoles; Indoles; Male; Middle Aged; Oxazoles; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Smokers; Sputum

2019
Safety, Tolerability, and Pharmacokinetics of a New Formulation of Nemiralisib Administered via a Dry Powder Inhaler to Healthy Individuals.
    Clinical therapeutics, 2019, Volume: 41, Issue:6

    Topics: Administration, Inhalation; Double-Blind Method; Dry Powder Inhalers; Humans; Indazoles; Indoles; Oxazoles; Piperazines

2019
Drug Interactions for Low-Dose Inhaled Nemiralisib: A Case Study Integrating Modeling, In Vitro, and Clinical Investigations.
    Drug metabolism and disposition: the biological fate of chemicals, 2020, Volume: 48, Issue:4

    Topics: Administration, Inhalation; Adolescent; Adult; Aged; Area Under Curve; Clarithromycin; Computer Simulation; Cross-Over Studies; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Drug Interactions; Erythromycin; Healthy Volunteers; Humans; Indazoles; Indoles; Itraconazole; Male; Microsomes, Liver; Midazolam; Middle Aged; Models, Biological; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Prospective Studies; Retrospective Studies; Young Adult

2020
Nemiralisib in Patients with an Acute Exacerbation of COPD: Placebo-Controlled, Dose-Ranging Study.
    International journal of chronic obstructive pulmonary disease, 2021, Volume: 16

    Topics: Bronchodilator Agents; Double-Blind Method; Forced Expiratory Volume; Humans; Indazoles; Indoles; Oxazoles; Phosphatidylinositol 3-Kinases; Piperazines; Pulmonary Disease, Chronic Obstructive

2021

Other Studies

11 other study(ies) available for oxazoles and indazoles

ArticleYear
Characterization of imidazoline-guanidinium receptive sites in renal medulla from human kidney.
    American journal of hypertension, 1992, Volume: 5, Issue:4 Pt 2

    Topics: Adrenergic alpha-Antagonists; Animals; Dioxanes; Guanidine; Guanidines; Humans; Idazoxan; Imidazoline Receptors; Indazoles; Kidney Medulla; Oxazoles; Rabbits; Receptors, Adrenergic; Receptors, Cell Surface; Receptors, Drug; Tritium; Yohimbine

1992
Anti-inflammatory properties of 4,5-diphenyl-2-oxazolepropionic acid (oxaprozin).
    Agents and actions, 1974, Volume: 4, Issue:3

    Topics: Airway Obstruction; Analgesics; Animals; Anti-Inflammatory Agents; Arthritis, Rheumatoid; Aspirin; Bradykinin; Carrageenan; Dogs; Edema; Emulsions; Encephalomyelitis, Autoimmune, Experimental; Female; Fever; Freund's Adjuvant; Indazoles; Male; Molecular Weight; Mycobacterium; Oxazoles; Peptic Ulcer; Propionates; Rats; Sulfanilamides; Synovitis; Time Factors; Uric Acid; Yeasts

1974
[Derivatives of 5-hydroxymethylen-cis-4-caranone].
    Il Farmaco; edizione scientifica, 1974, Volume: 29, Issue:1

    Topics: Animals; Bridged-Ring Compounds; Central Nervous System; Drug Evaluation, Preclinical; Hydrogenation; Indazoles; Oxazoles; Pyrazoles; Spectrophotometry, Infrared

1974
An oxazolo[3,2-b]indazole route to 1H-indazolones.
    Organic letters, 2009, Jul-02, Volume: 11, Issue:13

    Topics: Alcohols; Benzylamines; Indazoles; Molecular Structure; Oxazoles

2009
Design, synthesis and SAR of indazole and benzoisoxazole containing 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists.
    Bioorganic & medicinal chemistry letters, 2011, Oct-15, Volume: 21, Issue:20

    Topics: Animals; Cell Line; Cyclohexanes; Dogs; Drug Design; Humans; Indazoles; Oxazoles; Rats; Receptors, CCR2; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG

2011
A one-pot-three-step route to triazolotriazepinoindazolones from oxazolino-2H-indazoles.
    Organic letters, 2012, Aug-03, Volume: 14, Issue:15

    Topics: Alkynes; Catalysis; Cyclization; Hydrocarbons, Brominated; Indazoles; Molecular Structure; Oxazoles; Palladium; Triazoles

2012
Benzofuran-, benzothiophene-, indazole- and benzisoxazole-quinones: excellent substrates for NAD(P)H:quinone oxidoreductase 1.
    Bioorganic & medicinal chemistry, 2013, Jun-01, Volume: 21, Issue:11

    Topics: Antineoplastic Agents; Benzofurans; Cell Line, Tumor; Enzyme Assays; Humans; Indazoles; NAD(P)H Dehydrogenase (Quinone); Oxazoles; Oxidation-Reduction; Quinones; Thiophenes

2013
Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.
    PloS one, 2015, Volume: 10, Issue:5

    Topics: Antineoplastic Combined Chemotherapy Protocols; Aza Compounds; Benzimidazoles; beta Catenin; Cell Line, Tumor; Cell Proliferation; Humans; Imidazoles; Indazoles; Indoles; Melanoma; Molecular Targeted Therapy; Mutation; Oxazoles; Oximes; Proto-Oncogene Proteins B-raf; Proto-Oncogene Proteins c-myc; Proto-Oncogene Proteins p21(ras); Pyridones; Pyrimidinones; Quinolines; Sulfonamides; Triazoles; Vemurafenib

2015
Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3-Kinase δ for the Treatment of Respiratory Disease.
    Journal of medicinal chemistry, 2015, Sep-24, Volume: 58, Issue:18

    Topics: Administration, Inhalation; Animals; Asthma; Female; Humans; Indazoles; Indoles; Isoenzymes; Male; Microsomes; Molecular Docking Simulation; Ovalbumin; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Pneumonia; Pulmonary Disease, Chronic Obstructive; Rabbits; Rats; Rats, Sprague-Dawley; Respiratory Tract Diseases; Stereoisomerism; Structure-Activity Relationship; Sulfonamides; Th2 Cells

2015
Indazole, Pyrazole, and Oxazole Derivatives Targeting Nitric Oxide Synthases and Carbonic Anhydrases.
    ChemMedChem, 2016, 08-19, Volume: 11, Issue:16

    Topics: Carbonic Anhydrase I; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indazoles; Molecular Structure; Nitric Oxide Synthase Type I; Oxazoles; Pyrazoles; Structure-Activity Relationship

2016
Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption.
    Clinical pharmacokinetics, 2022, Volume: 61, Issue:2

    Topics: Absorption, Physiological; Administration, Inhalation; Administration, Oral; Animals; Computer Simulation; Humans; Indazoles; Indoles; Models, Biological; Oxazoles; Piperazines; Rats

2022