oxazoles has been researched along with gw 6471 in 71 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (8.45) | 29.6817 |
| 2010's | 56 (78.87) | 24.3611 |
| 2020's | 9 (12.68) | 2.80 |
| Authors | Studies |
|---|---|
| Cobb, JE; Galardi, CM; Kliewer, SA; Lambert, MH; McKee, DD; Montana, VG; Moore, JT; Nolte, RT; Parks, DJ; Plunket, KD; Shearer, BG; Stanley, TB; Stimmel, JB; Willson, TM; Xu, HE | 1 |
| Corton, JC; Dohm, GL; Houmard, JA; Kraus, WE; Lang, DB; Li, S; MacLean, PS; Muoio, DM; Way, JM; Winegar, DA | 1 |
| Ding, L; Liang, XG; Lou, YJ | 1 |
| Cwinn, MA; Jones, SP; Kennedy, SW | 1 |
| Chapman, V; Kendall, DA; Sagar, DR | 1 |
| de Koning, LJ; Ihling, C; Mechtler, K; Müller, MQ; Rau, O; Schmidt, A; Schubert-Zsilavecz, M; Sinz, A; Syha, Y | 1 |
| Castiglia, S; Collino, M; Fantozzi, R; Kapoor, A; Thiemermann, C | 1 |
| Chen, MS; Hou, N; Liu, SM; Luo, JD; Luo, MS; Sun, P; Xiao, Q; Zhang, GS; Zhang, HN | 1 |
| Blomeyer, C; Kehl, F; Lange, M; Lazariotto, M; Lotz, C; Pociej, J; Redel, A; Roewer, N; Schmidt, J; Smul, TM; Stumpner, J; Tischer-Zeitz, T | 1 |
| Chartoumpekis, DV; Habeos, IG; Kyriazopoulou, VE; Papavassiliou, AG; Psyrogiannis, AI; Ziros, PG | 1 |
| Aburatani, H; Doi, T; Hamakubo, T; Ishimoto, K; Kawabe, N; Kodama, T; Nakamura, H; Sakai, J; Tachibana, K; Tanaka, T; Yamasaki, D | 1 |
| Inagaki, K; Makino, H; Matsumoto, Y; Miyoshi, T; Nakamura, E; Otsuka, F; Sada, KE; Takano, M; Takeda, M; Tsukamoto, N | 1 |
| Müller, MQ; Sinz, A | 1 |
| Biemann, R; Eder, K; Kämmerer, I; Ringseis, R; Wen, G | 1 |
| Alen, F; Gómez, R; Orio, L; Pavón, FJ; Reyes-Cabello, C; Rivera, P; Rodríguez de Fonseca, F; Serrano, A | 1 |
| Fu, Y; Jiang, Z; Li, X; Mo, Z; Tang, C; Xiao, J; Yin, K; Yu, X; Zha, X; Zhao, G | 1 |
| Fernandez-Espejo, E; Flores, JA; Ruiz-Medina, J; Tasset, I; Tunez, I; Valverde, O | 1 |
| Asavapanumas, N; Chatsudthipong, V; Kittayaruksakul, S; Meetam, P; Muanprasat, C; Soodvilai, S | 1 |
| Kumar, A; Kumar, P; Qiao, Z; Song, ZH | 1 |
| Amu, S; Clifford, E; Downer, EJ; Fallon, PG; Moynagh, PN | 1 |
| Barreto-Torres, G; Javadov, S; Parodi-Rullán, R | 1 |
| Cai, J; Lin, B; Qu, J; Snider, BJ; Sun, L; Wu, M; Wu, S | 1 |
| Avagliano, C; Calignano, A; Citraro, R; Cosco, D; D'Agostino, G; De Sarro, G; Di Marzo, V; Gatta, L; Guida, F; Maione, S; Petrosino, S; Russo, E; Russo, R; Scicchitano, F; van Luijtelaar, G; van Rijn, CM | 1 |
| Ji, M; Li, Y; Lin, Q; Lin, R; Ren, F; Wang, W; Zhang, J | 1 |
| Ihling, CH; Kölbel, K; Müller, MQ; Schwarz, R; Sinz, A; Tänzler, D | 1 |
| Chen, TH; Chiou, YL; Huang, YC; Li, TT; Liu, KC; Liu, LL; Yang, CH | 1 |
| Abu Aboud, O; Weiss, RH; Wettersten, HI | 1 |
| Bai, L; Ji, M; Lin, R; Lu, Y; Qiao, H; Ren, F; Wang, W; Yang, L; Zhang, J | 1 |
| Han, L; Li, MG; Ye, P | 1 |
| Byun, JH; Hah, YS; Hwang, SC; Joo, HH; Kang, YH; Kim, JW; Park, BW; Rho, GJ; Sung, IY; Woo, DK | 1 |
| Kuwabara, H; Mantoku, D; Marunaka, Y; Matsumura, H; Nakahari, T; Nakano, T; Sawabe, Y; Shimamoto, C; Sugiyama, N; Takahashi, Y; Tanaka, S | 1 |
| Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B | 1 |
| Chen, S; Huang, J; Huang, Q; Liu, B; Liu, P; Luo, J; Pan, X; Zang, L; Zeng, Z; Zhou, S | 1 |
| Capoccia, E; Cipriano, M; De Filippis, D; Esposito, G; Iuvone, T; Negro, L; Sarnelli, G; Scuderi, C; Steardo, L | 1 |
| Abu Aboud, O; Bultman, S; Donohoe, D; Fitch, M; Hellerstein, M; Riiff, T; Weiss, RH | 1 |
| Audano, M; Azcoitia, I; Carozzi, V; Caruso, D; Cavaletti, G; Cermenati, G; Crestani, M; D'Antonio, M; De Fabiani, E; Ferri, C; Garcia-Segura, LM; Giatti, S; Melcangi, RC; Mitro, N; Pettinato, E; Porretta-Serapiglia, C; Saez, E; Scurati, S | 1 |
| Ann, SJ; Chung, JH; Jang, J; Kang, SM; Kim, SH; Lee, SH; Park, BH; Park, S | 1 |
| Kim, J; Lee, H; Park, SD; Roh, JS; Shin, SS; Woo, S; Yoon, M | 1 |
| Baram, SM; Dehpour, AR; Rahimian, R; Rahmatollahi, M; Saeedi Saravi, SS | 1 |
| Chen, XQ; Lü, J; Wang, MJ; Wu, SH | 1 |
| Jiang, Q; Li, X; Yang, T; Yang, Y; Zhang, H | 1 |
| Dong, JM; Dong, ZX; Hang, PZ; Hou, TT; Li, WM; Li, Y; Liu, GZ; Liu, Y; Liu, YW; Shi, H; Sun, L; Wang, XB; Yuan, Y; Zhan, CC; Zhao, GQ; Zhao, J; Zhao, JJ; Zhou, JH | 1 |
| Campos, CR; Cannon, RE; Chan, GN; Evans, RA; Miller, DS; More, VR; Oliver, KD | 1 |
| Hosogi, S; Inui, T; Marunaka, Y; Matsumura, H; Nakahari, T; Sawabe, Y; Shimamoto, C; Tanaka, S | 1 |
| Agarwal, AK; Garg, A; Sankella, S | 1 |
| Cao, R; Dan, HC; Jiang, W; Ju, L; Qian, G; Wang, G; Wang, X; Wang, Y; Wu, M; Xiao, Y | 1 |
| Kim, J; Lee, H; Lim, J; Shin, SS; Yang, H; Yoon, M; Yoon, S | 1 |
| Bagdas, D; Carroll, FI; Damaj, MI; Greenwald, M; Jackson, A; Lichtman, AH; Miles, MF; Muldoon, PP | 1 |
| Ammazzalorso, A; Basile, M; Cama, A; Cataldi, A; Cimini, A; Cristiano, L; De Lellis, L; di Giacomo, V; Di Marcantonio, MC; Florio, R; Mariani-Costantini, R; Mincione, G; Prasad, SC; Sanna, M; Verginelli, F; Verzilli, D | 1 |
| AlSharari, S; Bagdas, D; Donvito, G; Imad Damaj, M; Ivy Carroll, F; Jackson, A; Kulkarni, AR; Lichtman, AH; Meade, JA; Papke, RL; Rahimpour, E; Thakur, GA; Toma, W | 1 |
| Chen, Y; Fillmore, N; Gao, S; Harrington, J; Liu, P; Murphy, E; Springer, D; Stoehr, A; Wang, X; Yang, Y; Zhang, X; Zhu, J | 1 |
| Gu, QY; Jiang, B; Ni, YF; Wang, FY; Wang, H; Wang, JL; Wang, YJ | 1 |
| D'Aniello, E; Damaj, MI; Di Marzo, V; Donvito, G; Giordano, C; Guida, F; Ignatowska-Jankowska, BM; Jackson, A; Lichtman, AH; Maione, S; Mechoulam, R; Muldoon, P; Mustafa, MA; Parker, L; Petrie, GN; Piscitelli, F; Sim-Selley, L; Smoum, R; Vitale, RM | 1 |
| Babaei, J; Gavzan, H; Hashemi, F; Sayyah, M | 1 |
| Anraku, M; Erickson, L; Eto, N; Kawahara, S; Matsushita, Y; Motoba, I; Nakanishi, T; Sugamoto, K; Suzuki, R; Yamaguchi, Y | 1 |
| Dong, T; Fukunaga, K; Ibata, T; Imachi, H; Iwama, H; Kobayashi, T; Lyu, J; Murao, K; Sato, S; Yonezaki, K; Yoshimoto, T; Zhang, G | 1 |
| Amoroso, R; Arduini, A; Cama, A; Cataldi, A; De Lellis, L; di Giacomo, V; Florio, R; Gallorini, M; Mariani-Costantini, R; Natale, A; Perconti, S; Sanna, M; Verginelli, F; Veschi, S | 1 |
| Jiao, S; Li, Q; Pan, M; Qu, J; Reinach, PS; Srinivasalu, N; Yan, J; Yang, Y; Zhou, X | 1 |
| Ikari, A; Manabe, A; Tabuchi, Y; Takashina, Y | 1 |
| Abbas, MA; Aldaoud, N; Aldossary, SA; Alsalem, M; Altarifi, A; El-Salem, K; Haddad, M; Jaffal, SM; Kalbouneh, H | 1 |
| Du, M; Mao, X; Wang, H | 1 |
| Cong, H; Fan, B; Gu, J; Wang, T; Zhong, W | 1 |
| Finn, DP; Gaspar, JC; Llorente-Berzal, A; Okine, BN; Roche, M | 1 |
| Chen, W; Fang, H; Hong, Z; Jin, W; Li, L; Yang, L; Yi, Z; Zhang, G; Zhang, Y | 1 |
| Burdge, GC; Calder, PC; Cooper, C; Lillycrop, KA; Pérez-Mojica, JE | 1 |
| Cao, M; Chen, D; Han, X; Ji, F; Liufu, N; Yao, W; Zeng, Q | 1 |
| Beretta, C; Candura, SM; Cervio, M; Colucci, M; De Angelis, S; Dellabianca, A; Faniglione, M; Tonini, S | 1 |
| Cai, D; Guo, F; Holm, L; Li, Y; Liu, HY; Zhang, K; Zhou, B | 1 |
| Astakhova, AA; Chistyakov, DV; Goriainov, SV; Sergeeva, MG | 1 |
| Du, ZW; Hou, H; Li, JY; Wang, Q; Wei, XC; Wu, XA; Yang, JY; Zhang, W | 1 |
| Cheng, LH; Cui, S; Ge, CL; Guo, YT; Hao, HP; He, QX; Pan, XJ; Wang, GJ; Wang, H; Yan, TT; Zhang, PF; Zhou, JY | 1 |
71 other study(ies) available for oxazoles and gw 6471
| Article | Year |
|---|---|
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; DNA-Binding Proteins; Humans; Inhibitory Concentration 50; Ligands; Models, Molecular; Molecular Sequence Data; Nuclear Receptor Co-Repressor 2; Oxazoles; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Sequence Alignment; Structure-Activity Relationship; Transcription Factors; Tyrosine | 2002 |
Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta.
Topics: Animals; Blood Glucose; Carrier Proteins; Energy Metabolism; Fatty Acids; Fatty Acids, Nonesterified; Homeostasis; Humans; Ion Channels; Isoenzymes; Ketones; Lactic Acid; Liver Glycogen; Mice; Mice, Knockout; Mitochondrial Proteins; Muscle, Skeletal; Oxazoles; Oxidation-Reduction; Physical Conditioning, Animal; Protein Kinases; Rats; Receptors, Cytoplasmic and Nuclear; Thiazoles; Transcription Factors; Transcription, Genetic; Tyrosine; Uncoupling Protein 3 | 2002 |
Time-dependence of cardiomyocyte differentiation disturbed by peroxisome proliferator-activated receptor alpha inhibitor GW6471 in murine embryonic stem cells in vitro.
Topics: Animals; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Mice; Myocytes, Cardiac; Oxazoles; p38 Mitogen-Activated Protein Kinases; PPAR alpha; Time Factors; Tyrosine | 2007 |
Exposure to perfluorooctane sulfonate or fenofibrate causes PPAR-alpha dependent transcriptional responses in chicken embryo hepatocytes.
Topics: Alkanesulfonic Acids; Animals; Cell Survival; Cells, Cultured; Chick Embryo; Dose-Response Relationship, Drug; Environmental Pollutants; Fenofibrate; Fluorocarbons; Gene Expression Regulation, Enzymologic; Hepatocytes; Lipid Metabolism; Liver; Oxazoles; PPAR alpha; RNA, Messenger; Time Factors; Transcription, Genetic; Tyrosine | 2008 |
Inhibition of fatty acid amide hydrolase produces PPAR-alpha-mediated analgesia in a rat model of inflammatory pain.
Topics: Amidohydrolases; Analgesia; Animals; Benzamides; Carbamates; Carrageenan; Disease Models, Animal; Inflammation; Oxazoles; Pain; Piperidines; PPAR gamma; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Tyrosine | 2008 |
An innovative method to study target protein-drug interactions by mass spectrometry.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Drug Discovery; Hydrolysis; Ligands; Mass Spectrometry; Models, Molecular; Oxazoles; Pharmaceutical Preparations; PPAR alpha; Protein Binding; Protein Conformation; Reproducibility of Results; Tyrosine | 2009 |
Activation of peroxisome proliferator-activated receptor-beta/delta attenuates myocardial ischemia/reperfusion injury in the rat.
Topics: Animals; Cyclooxygenase 2; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Hemodynamics; Male; Myocardial Reperfusion Injury; Myocardium; Nitric Oxide Synthase Type II; Oxazoles; Phosphorylation; PPAR alpha; PPAR delta; PPAR-beta; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Thiazoles; Tyrosine | 2010 |
Leptin induces hypertrophy through activating the peroxisome proliferator-activated receptor α pathway in cultured neonatal rat cardiomyocytes.
Topics: Animals; Animals, Newborn; Blotting, Western; Cardiomegaly; Cell Culture Techniques; Cell Enlargement; Cells, Cultured; Dose-Response Relationship, Drug; Electrophoretic Mobility Shift Assay; Enzyme-Linked Immunosorbent Assay; Leptin; Myocytes, Cardiac; Obesity; Oxazoles; PPAR alpha; Protein Binding; Rats; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Tyrosine | 2010 |
Activation of peroxisome-proliferator-activated receptors α and γ mediates remote ischemic preconditioning against myocardial infarction in vivo.
Topics: Anilides; Animals; Ischemic Preconditioning, Myocardial; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Oxazoles; PPAR alpha; PPAR gamma; Prostaglandin D2; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tyrosine | 2011 |
Brown adipose tissue responds to cold and adrenergic stimulation by induction of FGF21.
Topics: Adipocytes; Adipose Tissue, Brown; Adrenergic beta-Agonists; Animals; Cell Line, Transformed; Cold Temperature; Dioxoles; Fibroblast Growth Factors; Male; Mice; Mice, Inbred C57BL; Oxazoles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Receptors, Adrenergic, beta-3; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thermogenesis; Trans-Activators; Transcription Factors; Transcriptional Activation; Tyrosine | 2011 |
Fenofibrate suppresses growth of the human hepatocellular carcinoma cell via PPARα-independent mechanisms.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin A; Cyclin-Dependent Kinase Inhibitor p27; DNA-Directed DNA Polymerase; E2F1 Transcription Factor; Fenofibrate; Flow Cytometry; Humans; Immunoblotting; Liver Neoplasms; Oxazoles; Phosphorylation; PPAR alpha; Proto-Oncogene Proteins c-akt; RNA Interference; RNA, Small Interfering; Signal Transduction; Tumor Suppressor Proteins; Tyrosine | 2011 |
Peroxisome proliferator-activated receptor activity is involved in the osteoblastic differentiation regulated by bone morphogenetic proteins and tumor necrosis factor-α.
Topics: Alkaline Phosphatase; Animals; Antigens, Differentiation; Bone Morphogenetic Proteins; Cell Differentiation; Cell Line, Tumor; Collagen Type I; Core Binding Factor Alpha 1 Subunit; Gene Expression; Intracellular Signaling Peptides and Proteins; Mice; Osteoblasts; Osteocalcin; Oxazoles; PPAR alpha; PPAR gamma; Receptors, Tumor Necrosis Factor; Signal Transduction; Smad Proteins; Tumor Necrosis Factor-alpha; Tyrosine | 2012 |
Chemical cross-linking and high-resolution mass spectrometry to study protein-drug interactions.
Topics: Amino Acid Sequence; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Electrophoresis, Polyacrylamide Gel; Esters; Hydrolysis; Ligands; Molecular Sequence Data; Nanotechnology; Oxazoles; Peptides; Pharmaceutical Preparations; PPAR alpha; Proteins; Spectrometry, Mass, Electrospray Ionization; Statistics as Topic; Succinimides; Tyrosine | 2012 |
13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages.
Topics: Animals; Apolipoprotein A-I; ATP Binding Cassette Transporter 1; ATP Binding Cassette Transporter, Subfamily G, Member 1; ATP-Binding Cassette Transporters; Biomarkers; Cell Line; Cholesterol; Gene Expression; Linoleic Acids; Lipoproteins; Liver X Receptors; Macrophages; Mice; Orphan Nuclear Receptors; Oxazoles; Peroxisome Proliferator-Activated Receptors; Scavenger Receptors, Class B; Transcriptional Activation; Tyrosine | 2011 |
Effects of the anandamide uptake blocker AM404 on food intake depend on feeding status and route of administration.
Topics: Animals; Arachidonic Acids; Eating; Endocannabinoids; Energy Intake; Feeding Behavior; Food Deprivation; Injections, Intraperitoneal; Injections, Intraventricular; Male; Mice; Mice, Knockout; Nutritional Status; Oxazoles; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Satiation; Tyrosine | 2012 |
OxLDL up-regulates Niemann-Pick type C1 expression through ERK1/2/COX-2/PPARα-signaling pathway in macrophages.
Topics: Atherosclerosis; Base Sequence; Carrier Proteins; Cell Line; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Lipoproteins, LDL; Macrophages; MAP Kinase Signaling System; Membrane Glycoproteins; Models, Biological; Niemann-Pick C1 Protein; Oxazoles; PPAR alpha; RNA, Messenger; RNA, Small Interfering; Tyrosine; Up-Regulation | 2012 |
Alteration of neuropathic and visceral pain in female C57BL/6J mice lacking the PPAR-α gene.
Topics: Animals; Female; Hyperalgesia; Mice; Mice, Inbred C57BL; Mice, Knockout; Neuralgia; Oxazoles; PPAR alpha; Sciatic Nerve; Tyrosine; Visceral Pain | 2012 |
Fenofibrate down-regulates renal OCT2-mediated organic cation transport via PPARα-independent pathways.
Topics: Animals; Biological Transport; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cycloheximide; Down-Regulation; Epithelial Cells; Fenofibrate; Hypolipidemic Agents; Kidney Cortex; Male; Membrane Transport Proteins; Mice; Mice, Inbred ICR; Organic Cation Transport Proteins; Organic Cation Transporter 2; Oxazoles; PPAR alpha; Pyrimidines; Rabbits; Swine; Tyrosine | 2012 |
Effects of palmitoylethanolamide on aqueous humor outflow.
Topics: Amides; Animals; Aqueous Humor; Blotting, Western; Camphanes; Dose-Response Relationship, Drug; Endocannabinoids; Enzyme Activation; Ethanolamines; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organ Culture Techniques; Oxazoles; Palmitic Acids; Phosphorylation; Piperidines; PPAR alpha; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Rimonabant; Swine; Trabecular Meshwork; Tyrosine | 2012 |
The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.
Topics: Analgesics; Animals; Benzoxazines; Cannabinoids; Encephalomyelitis, Autoimmune, Experimental; Gene Expression Regulation; HEK293 Cells; Humans; Interferon Inducers; Interferon Regulatory Factor-3; Interferon-beta; Mice; Morpholines; Naphthalenes; Oxazoles; Poly I-C; PPAR alpha; Tyrosine | 2012 |
The role of PPARα in metformin-induced attenuation of mitochondrial dysfunction in acute cardiac ischemia/reperfusion in rats.
Topics: Animals; Electron Transport Complex I; Electron Transport Complex II; Hypoglycemic Agents; L-Lactate Dehydrogenase; Male; Metformin; Mitochondria, Heart; Myocardial Reperfusion Injury; Myocytes, Cardiac; Oxazoles; PPAR alpha; Rats; Rats, Sprague-Dawley; Tyrosine | 2012 |
Pretreatment with proteasome inhibitors protects against oxidative injuries via PPARα-dependent and -independent pathways in ARPE-19 cells.
Topics: Aldehydes; Anilides; Cells, Cultured; Cysteine Proteinase Inhibitors; Electrophoretic Mobility Shift Assay; Humans; Lactones; Leupeptins; Oxazoles; Oxidative Stress; PPAR alpha; Retinal Pigment Epithelium; Tyrosine; Vitamin K 3 | 2012 |
Antiepileptic action of N-palmitoylethanolamine through CB1 and PPAR-α receptor activation in a genetic model of absence epilepsy.
Topics: Amides; Animals; Anticonvulsants; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Antagonists; Dose-Response Relationship, Drug; Electroencephalography; Endocannabinoids; Epilepsy, Absence; Ethanolamines; Glycerides; Injections, Intraventricular; Lipid Metabolism; Male; Oxazoles; Palmitic Acids; Piperidines; Polyunsaturated Alkamides; PPAR alpha; Pyrazoles; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Rimonabant; Tyrosine | 2013 |
PPARα agonist fenofibrate attenuates TNF-α-induced CD40 expression in 3T3-L1 adipocytes via the SIRT1-dependent signaling pathway.
Topics: 3T3-L1 Cells; Adipocytes; AMP-Activated Protein Kinases; Animals; Benzamides; Blotting, Western; CD40 Antigens; Fenofibrate; Mice; Naphthols; NF-kappa B; Niacinamide; Oxazoles; PPAR alpha; Pyrrolidines; RNA, Messenger; Signal Transduction; Sirtuin 1; Thiocarbamates; Tumor Necrosis Factor-alpha; Tyrosine | 2013 |
Monitoring conformational changes in peroxisome proliferator-activated receptor α by a genetically encoded photoamino acid, cross-linking, and mass spectrometry.
Topics: Benzophenones; Binding Sites; Butyrates; Cross-Linking Reagents; Genetic Variation; Ligands; Models, Molecular; Oxazoles; Phenylalanine; Phenylurea Compounds; PPAR alpha; Protein Binding; Protein Conformation; Protein Multimerization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine; Ultraviolet Rays | 2013 |
Fenofibrate suppresses melanogenesis in B16-F10 melanoma cells via activation of the p38 mitogen-activated protein kinase pathway.
Topics: Blotting, Western; Cell Line, Tumor; Cell Survival; Fenofibrate; Humans; Imidazoles; MAP Kinase Signaling System; Melanins; Melanoma, Experimental; Microphthalmia-Associated Transcription Factor; Oxazoles; PPAR alpha; Pyridines; Real-Time Polymerase Chain Reaction; RNA; Tyrosine | 2013 |
Inhibition of PPARα induces cell cycle arrest and apoptosis, and synergizes with glycolysis inhibition in kidney cancer cells.
Topics: Apoptosis; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Line; Cell Line, Tumor; Cell Survival; Cyclin D1; Cyclin-Dependent Kinase 4; Deoxyglucose; G1 Phase; Glucose; Glycolysis; Humans; Immunoblotting; Immunohistochemistry; Kidney Neoplasms; Oxazoles; PPAR alpha; Proto-Oncogene Proteins c-myc; Resting Phase, Cell Cycle; RNA Interference; Tyrosine | 2013 |
The protective effect of fenofibrate against TNF-α-induced CD40 expression through SIRT1-mediated deacetylation of NF-κB in endothelial cells.
Topics: Acetylation; Antioxidants; Benzamides; CD40 Antigens; Cells, Cultured; Fenofibrate; Human Umbilical Vein Endothelial Cells; Humans; Hypolipidemic Agents; Inflammation; Naphthols; Niacinamide; Oxazoles; PPAR alpha; Pyrrolidines; RNA Interference; RNA, Small Interfering; Signal Transduction; Sirtuin 1; Thiocarbamates; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Tyrosine; Up-Regulation | 2014 |
[The effect of PPARalpha signal channel on atorvastatin inhibiting MMP-9 expression in aging myocytes].
Topics: Aging; Animals; Atorvastatin; Cells, Cultured; Heptanoic Acids; Matrix Metalloproteinase 9; Muscle Cells; Oxazoles; PPAR alpha; Pyrroles; Rats; Rats, Wistar; Signal Transduction; Tyrosine | 2013 |
Cultured human periosteal-derived cells have inducible adipogenic activity and can also differentiate into osteoblasts in a perioxisome proliferator-activated receptor-mediated fashion.
Topics: Benzamides; Cell Differentiation; Cells, Cultured; Humans; Osteoblasts; Oxazoles; Periosteum; Peroxisome Proliferator-Activated Receptors; Pioglitazone; PPAR alpha; PPAR gamma; Pyridines; Pyrimidines; Reverse Transcriptase Polymerase Chain Reaction; Thiazolidinediones; Tyrosine | 2014 |
PPARα autocrine regulation of Ca²⁺-regulated exocytosis in guinea pig antral mucous cells: NO and cGMP accumulation.
Topics: Animals; Autocrine Communication; Butyrates; Calcium; Cyclic GMP; Exocytosis; Gastric Mucosa; Goblet Cells; Guinea Pigs; Male; Nitric Oxide; Oxazoles; Phenylurea Compounds; PPAR alpha; Pyloric Antrum; Tyrosine | 2014 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Mice; Morpholines; Naphthalenes; Oxazoles; Pentylenetetrazole; Peroxisome Proliferator-Activated Receptors; Pioglitazone; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Seizures; Thiazolidinediones; Tyrosine | 2015 |
Effects of ERK1/2/PPARα/SCAD signal pathways on cardiomyocyte hypertrophy induced by insulin-like growth factor 1 and phenylephrine.
Topics: Animals; Animals, Newborn; Butyryl-CoA Dehydrogenase; Cardiomegaly; Disease Models, Animal; Fatty Acids; Fenofibrate; Flavonoids; Insulin-Like Growth Factor I; MAP Kinase Signaling System; Myocytes, Cardiac; Oxazoles; Phenylephrine; Phosphorylation; PPAR alpha; Rats; Rats, Sprague-Dawley; Signal Transduction; Tyrosine | 2015 |
Palmitoylethanolamide Regulates Production of Pro-Angiogenic Mediators in a Model of β Amyloid-Induced Astrogliosis In Vitro.
Topics: Adenosine Triphosphate; Amides; Amyloid beta-Peptides; Animals; Astrocytes; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Ethanolamines; Gliosis; Humans; Neuroprotective Agents; Nitric Oxide; Nitric Oxide Synthase Type II; Oxazoles; p38 Mitogen-Activated Protein Kinases; Palmitic Acids; Peptide Fragments; PPAR alpha; Rats; S100 Calcium Binding Protein beta Subunit; Tyrosine; Vascular Endothelial Growth Factor A | 2015 |
PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth.
Topics: Animals; Carcinoma, Renal Cell; Cell Cycle Checkpoints; Cell Line, Tumor; Epithelial Cells; Gene Expression Regulation, Neoplastic; Humans; Kidney Neoplasms; Kidney Tubules; Metabolic Networks and Pathways; Mice; Mice, Nude; Organ Specificity; Oxazoles; Phosphorylation; PPAR alpha; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Signal Transduction; Tyrosine; Xenograft Model Antitumor Assays | 2015 |
Lack of sterol regulatory element binding factor-1c imposes glial Fatty Acid utilization leading to peripheral neuropathy.
Topics: Analysis of Variance; Animals; Blotting, Western; Chromatography, High Pressure Liquid; Fatty Acids; Metabolomics; Mice; Mice, Knockout; Microarray Analysis; Microscopy, Electron, Transmission; Myelin Sheath; Neuroglia; Oxazoles; Peripheral Nervous System Diseases; PPAR alpha; Real-Time Polymerase Chain Reaction; Sterol Regulatory Element Binding Protein 1; Tyrosine | 2015 |
PPARα agonists inhibit inflammatory activation of macrophages through upregulation of β-defensin 1.
Topics: Animals; Anti-Inflammatory Agents; beta-Defensins; Cell Line; Culture Media, Conditioned; Dose-Response Relationship, Drug; Fenofibrate; Gemfibrozil; Inflammation; Inflammation Mediators; Lipopolysaccharides; Macrophage Activation; Macrophages; Mice; Oxazoles; PPAR alpha; RNA Interference; Signal Transduction; Toll-Like Receptor 4; Transfection; Tyrosine; Up-Regulation | 2015 |
Herbal composition Gambigyeongsinhwan (4) from Curcuma longa, Alnus japonica, and Massa Medicata Fermentata inhibits lipid accumulation in 3T3-L1 cells and regulates obesity in Otsuka Long-Evans Tokushima Fatty rats.
Topics: 3T3-L1 Cells; Alnus; Animals; Anti-Obesity Agents; CCAAT-Enhancer-Binding Proteins; Curcuma; Drugs, Chinese Herbal; Fatty Acid-Binding Proteins; Lipid Metabolism; Male; Medicine, Korean Traditional; Mice; Obesity; Oxazoles; Phytotherapy; Plant Extracts; Plant Preparations; PPAR alpha; PPAR gamma; Rats, Inbred OLETF; RNA, Messenger; Triglycerides; Tyrosine; Weight Gain | 2015 |
Peroxisome Proliferator-Activated Receptor-α Inhibition Protects Against Doxorubicin-Induced Cardiotoxicity in Mice.
Topics: Animals; Atrial Function, Left; Benzoxazines; Cannabinoid Receptor Agonists; Cardiotonic Agents; Cardiotoxicity; Cytoprotection; Disease Models, Animal; Doxorubicin; Heart Diseases; Male; Malondialdehyde; Mice, Inbred BALB C; Morpholines; Myocardial Contraction; Myocytes, Cardiac; Naphthalenes; Oxazoles; PPAR alpha; Signal Transduction; Tumor Necrosis Factor-alpha; Tyrosine | 2016 |
BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1.
Topics: Acute Kidney Injury; Animals; Blood Urea Nitrogen; Cell Line; Creatinine; Glucuronidase; Heme Oxygenase-1; Heptanoic Acids; Imidazoles; Leucyl Aminopeptidase; Male; Malondialdehyde; Oxazoles; p38 Mitogen-Activated Protein Kinases; Peroxidase; Phosphorylation; PPAR alpha; Promoter Regions, Genetic; Protoporphyrins; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lipoxin; Reperfusion Injury; RNA, Messenger; Tyrosine | 2016 |
Effects of PPARα/PGC-1α on the energy metabolism remodeling and apoptosis in the doxorubicin induced mice cardiomyocytes in vitro.
Topics: Animals; Antibiotics, Antineoplastic; Apoptosis; Biomarkers; Cell Proliferation; Disease Models, Animal; Doxorubicin; Energy Metabolism; Fatty Acids, Nonesterified; Gene Expression Regulation; Glucose; Humans; Mice; Mitochondria; Myocytes, Cardiac; Oxazoles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Pyrimidines; Reactive Oxygen Species; Tyrosine; Up-Regulation | 2015 |
Fenofibrate inhibits atrial metabolic remodelling in atrial fibrillation through PPAR-α/sirtuin 1/PGC-1α pathway.
Topics: Animals; Atrial Fibrillation; Atrial Remodeling; Carbazoles; Cell Line; Fenofibrate; Heart Atria; Humans; Male; Middle Aged; Oxazoles; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; PPAR alpha; Rabbits; Sirtuin 1; Tyrosine | 2016 |
PPAR-α, a lipid-sensing transcription factor, regulates blood-brain barrier efflux transporter expression.
Topics: Alkanesulfonic Acids; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Brain; Capillaries; Clofibrate; Fasting; Fluorocarbons; Gene Expression Regulation; Linoleic Acid; Male; Mice, Inbred C57BL; Mice, Knockout; Multidrug Resistance-Associated Protein 2; Multidrug Resistance-Associated Proteins; Oxazoles; PPAR alpha; Rats, Sprague-Dawley; Tyrosine | 2017 |
PPARα induced NOS1 phosphorylation via PI3K/Akt in guinea pig antral mucous cells: NO-enhancement in Ca(2+)-regulated exocytosis.
Topics: Acetylcholine; Animals; Butyrates; Calcium; Exocytosis; Gastric Mucosa; Goblet Cells; Guinea Pigs; Male; Nitric Oxide; Nitric Oxide Synthase Type I; Oxazoles; Phenylurea Compounds; Phosphatidylinositol 3-Kinases; Phosphorylation; PPAR alpha; Protein Transport; Proto-Oncogene Proteins c-akt; Tyrosine | 2016 |
Characterization of the Mouse and Human Monoacylglycerol O-Acyltransferase 1 (Mogat1) Promoter in Human Kidney Proximal Tubule and Rat Liver Cells.
Topics: Acyltransferases; Anilides; Animals; Blotting, Northern; Caco-2 Cells; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Computational Biology; HT29 Cells; Humans; Kidney Tubules, Proximal; Liver; Mice; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Pyrimidines; Rats; Real-Time Polymerase Chain Reaction; Rosiglitazone; Sulfones; Thiazoles; Thiazolidinediones; Thiophenes; Tyrosine | 2016 |
Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway.
Topics: Anilides; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cyclin D1; Cyclin-Dependent Kinase 4; Cyclin-Dependent Kinase 6; Enzyme Activation; Epithelial-Mesenchymal Transition; ErbB Receptors; G1 Phase Cell Cycle Checkpoints; Glycogen Synthase Kinase 3 beta; Humans; Neoplasm Invasiveness; Oxazoles; PPAR gamma; Proto-Oncogene Proteins c-akt; Simvastatin; Tyrosine; Urinary Bladder; Urinary Bladder Neoplasms | 2016 |
The effects of herbal composition Gambigyeongsinhwan (4) on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells.
Topics: Alanine Transaminase; Animals; Anti-Inflammatory Agents; Biomarkers; Cytokines; Disease Models, Animal; Fenofibrate; Gene Expression Regulation, Enzymologic; Hep G2 Cells; Hepatitis; Hepatocytes; Humans; Hypolipidemic Agents; Inflammation Mediators; Lipids; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Obesity; Oxazoles; Plant Extracts; PPAR alpha; Rats, Inbred OLETF; RNA, Messenger; Transfection; Tyrosine | 2017 |
In vivo interactions between α7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α: Implication for nicotine dependence.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Anesthetics, Local; Animals; Benzamides; Bridged Bicyclo Compounds; Cocaine; Conditioning, Operant; Disease Models, Animal; Fenofibrate; Hypolipidemic Agents; Male; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Oxazoles; PPAR alpha; Pyrimidines; Self Administration; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2017 |
Effects of PPARα inhibition in head and neck paraganglioma cells.
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase 6; Caspase 7; Caspases; Caspases, Initiator; Cell Cycle; Cell Survival; Fluorescent Antibody Technique; Head and Neck Neoplasms; Humans; Immunohistochemistry; Oxazoles; PPAR alpha; Pyrimidines; Tumor Cells, Cultured; Tyrosine; Wound Healing | 2017 |
The interaction between alpha 7 nicotinic acetylcholine receptor and nuclear peroxisome proliferator-activated receptor-α represents a new antinociceptive signaling pathway in mice.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Amides; Animals; Azabicyclo Compounds; Benzamides; Bridged Bicyclo Compounds; Cannabinoid Receptor Antagonists; Ethanolamines; Furans; Male; Mice; Mice, Inbred ICR; Nicotinic Antagonists; Nociception; Oxazoles; Pain Measurement; Palmitic Acids; PPAR alpha; Receptor Cross-Talk; Signal Transduction; Tyrosine | 2017 |
A Systems Biology Approach to Investigating Sex Differences in Cardiac Hypertrophy.
Topics: Angiotensin II; Animals; Cardiomegaly; Disease Models, Animal; Female; Gene Expression Regulation; Gene Regulatory Networks; Male; Mice, Inbred C57BL; MicroRNAs; Myocardium; Oxazoles; PPAR alpha; Protein Interaction Maps; RNA, Messenger; Sex Characteristics; Sex Factors; Signal Transduction; Systems Biology; Time Factors; Tyrosine | 2017 |
Gemfibrozil has antidepressant effects in mice: Involvement of the hippocampal brain-derived neurotrophic factor system.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Brain-Derived Neurotrophic Factor; Carbazoles; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fenclonine; Fluoxetine; Gemfibrozil; Hippocampus; Immobility Response, Tonic; Indole Alkaloids; Male; Membrane Glycoproteins; Mice; Motor Activity; Oxazoles; Protein-Tyrosine Kinases; RNA, Small Interfering; Serotonin; Signal Transduction; Tyrosine | 2018 |
N-Oleoyl-glycine reduces nicotine reward and withdrawal in mice.
Topics: Animals; Brain Injuries, Traumatic; Cerebral Cortex; Conditioning, Classical; Glycine; Male; Mecamylamine; Mice; Nicotine; Oleic Acids; Oxazoles; PPAR alpha; Reward; Substance Withdrawal Syndrome; Tobacco Use Disorder; Tyrosine | 2019 |
A role for peroxisome proliferator-activated receptor α in anticonvulsant activity of docosahexaenoic acid against seizures induced by pentylenetetrazole.
Topics: Animals; Anticonvulsants; Docosahexaenoic Acids; Injections, Intraventricular; Male; Mice; Oxazoles; Pentylenetetrazole; PPAR alpha; Seizures; Tyrosine | 2018 |
Naturally occurring 3RS, 7R, 11R-phytanic acid suppresses in vitro T-cell production of interferon-gamma.
Topics: A549 Cells; Animals; Cell Differentiation; Female; Gene Expression Regulation; Genes, Reporter; Humans; Immunologic Factors; Interferon-gamma; Luciferases; Lymphocyte Activation; Mice; Mice, Inbred C57BL; NF-kappa B; Oxazoles; Phytanic Acid; Phytohemagglutinins; PPAR alpha; Primary Cell Culture; RNA, Messenger; Signal Transduction; Spleen; T-Box Domain Proteins; T-Lymphocytes; Tumor Necrosis Factor-alpha; Tyrosine | 2018 |
Selective peroxisome proliferator-activated receptor-α modulator K-877 regulates the expression of ATP-binding cassette transporter A1 in pancreatic beta cells.
Topics: Animals; ATP Binding Cassette Transporter 1; Benzoxazoles; Butyrates; Cell Line, Tumor; Diabetes Mellitus, Type 2; Diet, High-Fat; Disease Models, Animal; Dyslipidemias; Glucose; Glucose Intolerance; Humans; Hypolipidemic Agents; Insulin; Insulin-Secreting Cells; Lipid Metabolism; Male; Mice; Mice, Inbred C57BL; Oxazoles; PPAR alpha; Promoter Regions, Genetic; Rats; RNA, Messenger; Tyrosine | 2018 |
Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cells.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dichloroacetic Acid; Drug Screening Assays, Antitumor; Humans; Metformin; Oxazoles; Paraganglioma; Tyrosine | 2018 |
Opposing Effects of PPARα Agonism and Antagonism on Refractive Development and Form Deprivation Myopia in Guinea Pigs.
Topics: Animals; Apolipoprotein A-II; Bezafibrate; Biometry; Blotting, Western; Butyrates; Clofibrate; Collagen Type I; Disease Models, Animal; Electroretinography; Fluorescent Antibody Technique, Indirect; Guinea Pigs; Intraocular Pressure; Malate Dehydrogenase; Myopia; Oxazoles; Phenylurea Compounds; PPAR alpha; Refraction, Ocular; Sensory Deprivation; Tyrosine | 2018 |
Cyanidin Increases the Expression of Mg
Topics: Animals; Anthocyanins; Cation Transport Proteins; Cell Line; Colon; Epithelial Cells; Glucosides; Intestinal Mucosa; Magnesium; Magnesium Deficiency; Mice; Oxazoles; Phytochemicals; PPAR alpha; RNA, Messenger; TRPM Cation Channels; Tyrosine; Up-Regulation | 2019 |
Role of cannabinoid receptor 1 and the peroxisome proliferator-activated receptor α in mediating anti-nociceptive effects of synthetic cannabinoids and a cannabinoid-like compound.
Topics: Amides; Analgesics; Animals; Cannabinoids; Dronabinol; Ethanolamines; Iodoacetic Acid; Male; Motor Activity; Osteoarthritis; Oxazoles; Palmitic Acids; PPAR alpha; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Tyrosine | 2019 |
Phytanic acid activates PPARα to promote beige adipogenic differentiation of preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes, Beige; Adipogenesis; AMP-Activated Protein Kinases; Animals; Cell Differentiation; Gene Knockdown Techniques; Mice; Mitochondria; Oxazoles; Oxygen; Phosphorylation; Phytanic Acid; PPAR alpha; Receptors, Adrenergic, beta-3; Tyrosine | 2019 |
Oleic acid-induced perilipin 5 expression and lipid droplets formation are regulated by the PI3K/PPARα pathway in HepG2 cells.
Topics: Azo Compounds; Chromones; Gene Expression Regulation; Hep G2 Cells; Humans; Imidazoles; Lipid Droplets; Morpholines; Oleic Acid; Oxazoles; Perilipin-5; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; PPAR alpha; Pyridines; Staining and Labeling; Sulfones; Thiophenes; Tyrosine | 2019 |
Pharmacological Blockade of PPAR Isoforms Increases Conditioned Fear Responding in the Presence of Nociceptive Tone.
Topics: Analgesia; Anilides; Animals; Conditioning, Psychological; Extinction, Psychological; Fear; Formaldehyde; Freezing Reaction, Cataleptic; Gene Expression; Male; Nociceptive Pain; Oxazoles; PPAR alpha; PPAR delta; PPAR gamma; PPAR-beta; Rats; Rats, Sprague-Dawley; Sulfones; Thiophenes; Tyrosine | 2020 |
Anti-Inflammatory Effects of Fucoxanthinol in LPS-Induced RAW264.7 Cells through the NAAA-PEA Pathway.
Topics: Amides; Amidohydrolases; Animals; Anti-Inflammatory Agents; beta Carotene; Cytokines; Enzyme Inhibitors; Ethanolamines; Inflammation; Lipopolysaccharides; Mice; Nitric Oxide; Oxazoles; Palmitic Acids; PPAR alpha; RAW 264.7 Cells; Tyrosine | 2020 |
Docosahexaenoic acid and oleic acid induce altered DNA methylation of individual CpG loci in Jurkat T cells.
Topics: CpG Islands; DNA Methylation; Docosahexaenoic Acids; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Humans; Jurkat Cells; Oleic Acid; Oxazoles; Sequence Analysis, DNA; Transcription Factors; Tyrosine; Zinc Fingers | 2020 |
MG53 Protects against Sepsis-Induced Myocardial Dysfunction by Upregulating Peroxisome Proliferator-Activated Receptor-
Topics: Animals; Apoptosis; Humans; Inflammation; Models, Biological; Muscle Proteins; Myocardium; Myocytes, Cardiac; Oxazoles; Oxidative Stress; PPAR alpha; Protective Agents; Rats, Sprague-Dawley; Sepsis; Survival Analysis; Tyrosine; Up-Regulation; Vesicular Transport Proteins | 2020 |
A PPAR-α agonist protects the non-adrenergic, non-cholinergic inhibitory system of guinea pig trachea from the effect of inhaled ammonium persulphate: a pilot study.
Topics: Administration, Inhalation; Adrenergic beta-Agonists; Ammonium Sulfate; Animals; Electric Stimulation; Guinea Pigs; Isoproterenol; Male; Muscle Relaxation; Nerve Fibers; Oxazoles; Pilot Projects; PPAR alpha; Pyrimidines; Random Allocation; Trachea; Tyrosine | 2020 |
Co-option of PPARα in the regulation of lipogenesis and fatty acid oxidation in CLA-induced hepatic steatosis.
Topics: Acetyl-CoA Carboxylase; Acyl-CoA Dehydrogenase; Animals; Cells, Cultured; Disease Models, Animal; Fatty Acids; Gene Expression Regulation, Enzymologic; Hepatocytes; Histones; Insulin Resistance; Linoleic Acids, Conjugated; Lipogenesis; Liver; Male; Mice; Non-alcoholic Fatty Liver Disease; Oxazoles; Oxidation-Reduction; PPAR alpha; Signal Transduction; Transcriptional Activation; Tyrosine | 2021 |
Comparison of PPAR Ligands as Modulators of Resolution of Inflammation, via Their Influence on Cytokines and Oxylipins Release in Astrocytes.
Topics: Anilides; Animals; Anti-Inflammatory Agents; Astrocytes; Cells, Cultured; Extracellular Signal-Regulated MAP Kinases; Fenofibrate; Interleukin-10; Lipopolysaccharides; MAP Kinase Kinase 4; Oxazoles; Oxylipins; p38 Mitogen-Activated Protein Kinases; PPAR gamma; PPAR-beta; Rats; Rats, Wistar; Rosiglitazone; Thiazoles; Tumor Necrosis Factor-alpha; Tyrosine | 2020 |
Effects of dibutyl phthalate on lipid metabolism in liver and hepatocytes based on PPARα/SREBP-1c/FAS/GPAT/AMPK signal pathway.
Topics: Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cell Proliferation; Dibutyl Phthalate; fas Receptor; Gene Expression Regulation; Glycerol-3-Phosphate O-Acyltransferase; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolism; Liver; Male; Oxazoles; PPAR alpha; Rats; Rats, Sprague-Dawley; Ribonucleotides; Sterol Regulatory Element Binding Protein 1; Tyrosine | 2021 |
Silybin alleviates hepatic lipid accumulation in methionine-choline deficient diet-induced nonalcoholic fatty liver disease in mice via peroxisome proliferator-activated receptor α.
Topics: Animals; Choline; Diet; Lipid Metabolism; Liver; Methionine; Mice; Non-alcoholic Fatty Liver Disease; Oxazoles; PPAR alpha; Silybin; Tyrosine | 2021 |