Page last updated: 2024-08-21

oxazoles and doxazolidine

oxazoles has been researched along with doxazolidine in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's7 (70.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Barthel, BL; Burkhart, DJ; Hagadorn, JR; Koch, TH; Post, GC1
Barthel, BL; Chan, DC; Coldren, CD; Koch, GG; Koch, TH; Polinkovsky, M; Rudnicki, DL; Sun, H; Zhang, Z1
Barthel, BL; Burkhart, DJ; Colvin, SM; Kirby, TP; Koch, TH; Rudnicki, DL1
Barthel, B; Koch, TH; Shi, D; Xiao, D; Yan, B; Yang, D1
Charpentier, M; Guo, L; Lu, W; Xiao, D; Yan, B; Yang, D1
Barthel, BL; Koch, GG; Koch, TH; Mooz, EL; Wiener, LE1
Barthel, BL; Ganesh, AN; Koch, TH; Logie, J; McLaughlin, CK; Shoichet, BK; Shoichet, MS1
Balabanova, A; Bargmann, A; Frakes, SA; Grimm, J; Koch, TH; Tamura, R; Yin, H1
Al-Awar, R; Aman, A; Barthel, BL; Cogan, P; Ganesh, AN; Koch, TH; Logie, J; Shoichet, BK; Shoichet, MS1
Li, J; Li, X; Liu, P1

Other Studies

10 other study(ies) available for oxazoles and doxazolidine

ArticleYear
Doxazolidine, a proposed active metabolite of doxorubicin that cross-links DNA.
    Journal of medicinal chemistry, 2005, Dec-01, Volume: 48, Issue:24

    Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cross-Linking Reagents; Crystallography, X-Ray; DNA; Doxorubicin; Drug Screening Assays, Antitumor; Drug Stability; Humans; Hydrolysis; Models, Molecular; Oxazoles; Prodrugs

2005
Preclinical efficacy of a carboxylesterase 2-activated prodrug of doxazolidine.
    Journal of medicinal chemistry, 2009, Dec-10, Volume: 52, Issue:23

    Topics: Animals; Antineoplastic Agents; Blotting, Western; Carbamates; Carboxylesterase; Cell Line, Tumor; Cell Proliferation; Doxorubicin; Drug Evaluation, Preclinical; Female; Gene Expression Regulation, Enzymologic; Humans; Mice; Myocytes, Cardiac; Neoplasms; Oxazoles; Prodrugs; Rats; Regression Analysis

2009
Synthesis and biological characterization of protease-activated prodrugs of doxazolidine.
    Journal of medicinal chemistry, 2012, Jul-26, Volume: 55, Issue:14

    Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Doxorubicin; Drug Stability; Humans; Kinetics; Oxazoles; Peptide Hydrolases; Phosphates; Proteolysis

2012
Carboxylesterase-2 is a highly sensitive target of the antiobesity agent orlistat with profound implications in the activation of anticancer prodrugs.
    Biochemical pharmacology, 2013, Feb-01, Volume: 85, Issue:3

    Topics: Animals; Anti-Obesity Agents; Antineoplastic Agents; Camptothecin; Carboxylic Ester Hydrolases; Cell Line; Cell Survival; Doxorubicin; Drug Interactions; Female; Humans; Irinotecan; Lactones; Liver; Male; Mice; Orlistat; Oxazoles; Prodrugs; Rats; Species Specificity

2013
Regulation of carboxylesterase-2 expression by p53 family proteins and enhanced anti-cancer activities among 5-fluorouracil, irinotecan and doxazolidine prodrug.
    British journal of pharmacology, 2013, Volume: 168, Issue:8

    Topics: Animals; Antineoplastic Agents; Caco-2 Cells; Camptothecin; Carboxylesterase; Carboxylic Ester Hydrolases; Cell Line, Tumor; Doxorubicin; Fluorouracil; Gene Expression Regulation, Neoplastic; Hep G2 Cells; HT29 Cells; Humans; Irinotecan; Mice; Oxazoles; RNA Stability; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays

2013
Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde.
    Journal of medicinal chemistry, 2016, Mar-10, Volume: 59, Issue:5

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Cross-Linking Reagents; DNA, Neoplasm; Dose-Response Relationship, Drug; Doxorubicin; Drug Screening Assays, Antitumor; Esterases; Formaldehyde; Humans; Liver; Molecular Structure; Oxazoles; Prodrugs; Structure-Activity Relationship; Swine; Tumor Cells, Cultured

2016
Leveraging Colloidal Aggregation for Drug-Rich Nanoparticle Formulations.
    Molecular pharmaceutics, 2017, 06-05, Volume: 14, Issue:6

    Topics: Colloids; Doxorubicin; Drug Carriers; Drug Delivery Systems; Micelles; Nanoparticles; Oxazoles; Polymers

2017
Photoactivatable Prodrug of Doxazolidine Targeting Exosomes.
    Journal of medicinal chemistry, 2019, 02-28, Volume: 62, Issue:4

    Topics: Amino Acid Sequence; Antineoplastic Agents; Cell Line, Tumor; Cell Membrane; Cell-Penetrating Peptides; Cross-Linking Reagents; Doxorubicin; Exosomes; Humans; Nitrobenzenes; Oxazoles; Photolysis; Prodrugs; Ultraviolet Rays

2019
Colloidal Drug Aggregate Stability in High Serum Conditions and Pharmacokinetic Consequence.
    ACS chemical biology, 2019, 04-19, Volume: 14, Issue:4

    Topics: Animals; Antineoplastic Agents; Carbamates; Colloids; Doxorubicin; Drug Stability; Excipients; Female; Fulvestrant; Humans; MCF-7 Cells; Mice; Neoplasm Transplantation; Oxazoles; Polysorbates; Prodrugs; Proof of Concept Study; Serum

2019
Synthesis of Acid-Labile Poly(Doxazolidine) as a Polyprodrug with an Ultra-High Drug Content for Self-Delivery of High-Performance Chemotherapeutics.
    Molecular pharmaceutics, 2020, 02-03, Volume: 17, Issue:2

    Topics: Acetates; Antineoplastic Agents; Cell Proliferation; Cell Survival; Doxorubicin; Drug Delivery Systems; Drug Liberation; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Nanoparticles; Oxazoles; Polymers; Prodrugs

2020