Page last updated: 2024-08-21

oxazoles and diazonamide a

oxazoles has been researched along with diazonamide a in 34 studies

Research

Studies (34)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's27 (79.41)29.6817
2010's6 (17.65)24.3611
2020's1 (2.94)2.80

Authors

AuthorsStudies
Vedejs, E; Wang, J1
Barda, DA; Vedejs, E1
Fuerst, DE; Stoltz, BM; Wood, JL1
Methot, JL; Wipf, P1
Vedejs, E; Zajac, MA2
Bella, M; Chen, DY; Huang, X; Ling, T; Nicolaou, KC; Snyder, SA2
Eastman, KJ; Feldman, KS; Lessene, G1
Bheema Rao, P; Chen, DY; Hao, J; Huang, X; Nicolaou, KC; Rassias, G; Reddy, MV; Snyder, SA1
Bai, R; Cruz-Monserrate, Z; Fenical, W; Hamel, E; Howell, SB; Los, G; Mullaney, JT; Newman, DJ; Pettit, GR; Vervoort, HC; Williams, MD1
Cruz-Monserrate, Z; Hamel, E; Harran, PG; Mullaney, JT; Pettit, GR1
Burgett, AW; Harran, PG; Li, Q; Wei, Q1
Bigot, A; Huang, X; Koumbis, AE; Nicolaou, KC; Simonsen, KB; Snyder, SA1
Bella, M; Giannakakou, P; Giuseppone, N; Huang, X; Koumbis, AE; Nicolaou, KC; O'Brate, A; Rao, PB; Reddy, MV; Snyder, SA1
Brenzovich, WE; Chen, DY; Giannakakou, P; Giuseppone, N; Hao, J; Huang, X; Nicolaou, KC; O'Brate, A; Rao, PB; Rassias, G; Reddy, MV; Snyder, SA1
Nicolaou, KC; Snyder, SA1
Davies, JR; Kane, PD; Moody, CJ1
Bagley, MC; Lach, F; Moody, CJ; Palmer, FN; Pepper, AG; Poriel, C; Slawin, AM1
Moody, CJ; Sperry, J1
Atkins, AS; Burgett, AW; Harran, PG; McKnight, SL; Wang, X; Williams, NS1
Burgett, AW; Harran, PG; Shang, L; Wang, G; Wang, X1
Blake, AJ; Booker, JE; Boto, A; Churchill, GH; Green, CP; Ling, M; Meek, G; Pattenden, G; Prabhakaran, J; Sinclair, D1
Davies, JR; Lachia, M; Moody, CJ; Poriel, C; Wilson, C1
Cheung, CM; Goldberg, FW; Lynch, V; Magnus, P; Russell, CJ; Turnbull, R1
Lachia, M; Moody, CJ1
Gerstenberger, BS; Konopelski, JP; Lin, J; Stessman, NY1
Mai, CK; Sammakia, T; Sammons, MF1
Beaud, R; Guillot, R; Kouklovsky, C; Vincent, G1
Joo, B; Kalnins, T; Medne, Z; Mutule, I; Suna, E; Vedejs, E1
Peris, G; Vedejs, E1
Denizot, N; Guillot, R; Kouklovsky, C; Vincent, G1
David, N; Kitson, RR; Moody, CJ; Pasceri, R; Pradal, A1
Bai, R; Cruz-Monserrate, Z; Fenical, W; Hamel, E; Pettit, GR1

Reviews

2 review(s) available for oxazoles and diazonamide a

ArticleYear
Chasing molecules that were never there: misassigned natural products and the role of chemical synthesis in modern structure elucidation.
    Angewandte Chemie (International ed. in English), 2005, Feb-04, Volume: 44, Issue:7

    Topics: Biological Products; Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; History, 20th Century; History, 21st Century; Humans; Magnetic Resonance Spectroscopy; Marine Toxins; Molecular Structure; Oxazoles; Pharmacognosy; Plant Extracts; Spiro Compounds

2005
The synthetic challenge of diazonamide A, a macrocyclic indole bis-oxazole marine natural product.
    Natural product reports, 2008, Volume: 25, Issue:2

    Topics: Biological Products; Heterocyclic Compounds, 4 or More Rings; Marine Biology; Molecular Structure; Oxazoles

2008

Other Studies

32 other study(ies) available for oxazoles and diazonamide a

ArticleYear
A tyrosine-derived benzofuranone related to diazonamide A.
    Organic letters, 2000, Apr-20, Volume: 2, Issue:8

    Topics: Animals; Benzofurans; Chromatography, High Pressure Liquid; Cricetinae; Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Oxazoles; Tyrosine

2000
Progress toward synthesis of diazonamide A. Preparation of a 3-(oxazol-5-yl)-4-trifluoromethyl-sulfonyloxyindole and its use in biaryl coupling reactions.
    Organic letters, 2000, Apr-20, Volume: 2, Issue:8

    Topics: Heterocyclic Compounds, 4 or More Rings; Mesylates; Oxazoles; Thermodynamics

2000
Synthesis of C(3) benzofuran-derived bisaryl quaternary centers: approaches to diazonamide A.
    Organic letters, 2000, Nov-02, Volume: 2, Issue:22

    Topics: Antineoplastic Agents; Heterocyclic Compounds, 4 or More Rings; Indicators and Reagents; Molecular Conformation; Molecular Structure; Oxazoles; Stereoisomerism

2000
Synthetic studies toward diazonamide A. A novel approach for polyoxazole synthesis.
    Organic letters, 2001, May-03, Volume: 3, Issue:9

    Topics: Amides; Animals; Biological Products; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Oxazoles; Polymers; Structure-Activity Relationship; Urochordata

2001
Synthesis of the diazonamide A macrocyclic core via a Dieckmann-type cyclization.
    Organic letters, 2001, Aug-09, Volume: 3, Issue:16

    Topics: Antineoplastic Agents; Cyclization; Heterocyclic Compounds, 4 or More Rings; Indicators and Reagents; Magnetic Resonance Spectroscopy; Marine Toxins; Oxazoles

2001
Total synthesis of diazonamide A.
    Angewandte Chemie (International ed. in English), 2002, Sep-16, Volume: 41, Issue:18

    Topics: Animals; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Oxazoles; Urochordata

2002
Diazonamide synthesis studies: use of Negishi coupling to fashion diazonamide-related biaryls with defined axial chirality.
    Organic letters, 2002, Oct-03, Volume: 4, Issue:20

    Topics: Catalysis; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Oxazoles; Stereoisomerism

2002
The second total synthesis of diazonamide A.
    Angewandte Chemie (International ed. in English), 2003, Apr-17, Volume: 42, Issue:15

    Topics: Biological Factors; Cyclization; Heterocyclic Compounds, 4 or More Rings; Indoles; Iodides; Molecular Structure; Oxazoles; Samarium; Stereoisomerism

2003
Diazonamide A and a synthetic structural analog: disruptive effects on mitosis and cellular microtubules and analysis of their interactions with tubulin.
    Molecular pharmacology, 2003, Volume: 63, Issue:6

    Topics: Animals; Antineoplastic Agents; Cell Division; Depsipeptides; Drug Screening Assays, Antitumor; Guanosine Triphosphate; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrolysis; Microtubules; Mitosis; Oligopeptides; Oxazoles; Tubulin; Tumor Cells, Cultured

2003
Dolastatin 15 binds in the vinca domain of tubulin as demonstrated by Hummel-Dreyer chromatography.
    European journal of biochemistry, 2003, Volume: 270, Issue:18

    Topics: Animals; Binding Sites; Cattle; Chromatography, Gel; Colchicine; Depsipeptides; Heterocyclic Compounds, 4 or More Rings; Kinetics; Maytansine; Oligopeptides; Oxazoles; Protein Binding; Protein Structure, Tertiary; Tritium; Tubulin; Vinblastine; Vincristine

2003
A concise and flexible total synthesis of (-)-diazonamide A.
    Angewandte Chemie (International ed. in English), 2003, Oct-20, Volume: 42, Issue:40

    Topics: Biological Factors; Heterocyclic Compounds, 4 or More Rings; Models, Molecular; Molecular Conformation; Molecular Structure; Oxazoles

2003
A synthesis of the diazonamide heteroaromatic biaryl macrocycle/hemiaminal core.
    Organic letters, 2004, Jan-22, Volume: 6, Issue:2

    Topics: Cyclization; Heterocyclic Compounds, 4 or More Rings; Molecular Structure; Oxazoles; Palladium

2004
Studies toward diazonamide A: initial synthetic forays directed toward the originally proposed structure.
    Journal of the American Chemical Society, 2004, Aug-18, Volume: 126, Issue:32

    Topics: Epidermal Growth Factor; Heterocyclic Compounds, 4 or More Rings; Indoles; Oxazoles; Peptide Fragments

2004
Studies toward diazonamide A: development of a hetero-pinacol macrocyclization cascade for the construction of the bis-macrocyclic framework of the originally proposed structure.
    Journal of the American Chemical Society, 2004, Aug-18, Volume: 126, Issue:32

    Topics: Cyclization; Heterocyclic Compounds, 4 or More Rings; Oxazoles; Structure-Activity Relationship

2004
Chemistry and biology of diazonamide A: first total synthesis and confirmation of the true structure.
    Journal of the American Chemical Society, 2004, Oct-13, Volume: 126, Issue:40

    Topics: Heterocyclic Compounds, 4 or More Rings; Molecular Conformation; Oxazoles

2004
Chemistry and biology of diazonamide A: second total synthesis and biological investigations.
    Journal of the American Chemical Society, 2004, Oct-13, Volume: 126, Issue:40

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Heterocyclic Compounds, 4 or More Rings; Humans; Oxazoles; Structure-Activity Relationship

2004
The diazo route to diazonamide A. Studies on the indole bis-oxazole fragment.
    The Journal of organic chemistry, 2005, Sep-02, Volume: 70, Issue:18

    Topics: Heterocyclic Compounds, 4 or More Rings; Indoles; Oxazoles

2005
The diazo route to diazonamide A: studies on the tyrosine-derived fragment.
    Organic & biomolecular chemistry, 2005, Oct-21, Volume: 3, Issue:20

    Topics: Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Models, Molecular; Molecular Structure; Oxazoles; Stereoisomerism; Tyrosine

2005
Biomimetic approaches to diazonamide A. Direct synthesis of the indole bis-oxazole fragment by oxidation of a TyrValTrpTrp tetrapeptide.
    Chemical communications (Cambridge, England), 2006, Jun-14, Issue:22

    Topics: Biomimetics; Heterocyclic Compounds, 4 or More Rings; Indoles; Molecular Conformation; Oligopeptides; Oxazoles; Oxidation-Reduction; Stereoisomerism

2006
Therapeutic anticancer efficacy of a synthetic diazonamide analog in the absence of overt toxicity.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Feb-13, Volume: 104, Issue:7

    Topics: Animals; Antineoplastic Agents; Body Weight; Drug Evaluation, Preclinical; Heterocyclic Compounds, 4 or More Rings; Mice; Molecular Mimicry; Neoplasms, Experimental; Neutropenia; Ornithine-Oxo-Acid Transaminase; Oxazoles; Transplantation, Heterologous; Treatment Outcome

2007
Diazonamide toxins reveal an unexpected function for ornithine delta-amino transferase in mitotic cell division.
    Proceedings of the National Academy of Sciences of the United States of America, 2007, Feb-13, Volume: 104, Issue:7

    Topics: Animals; Antimitotic Agents; Antineoplastic Agents; Cell Death; Cell Division; Cell Line, Tumor; HeLa Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Mitochondrial Proteins; Mitosis; Oocytes; Ornithine-Oxo-Acid Transaminase; Oxazoles; RNA, Small Interfering; Tubulin Modulators; Xenopus

2007
Approaches to the quaternary stereocentre and to the heterocyclic core in diazonamide A using the Heck reaction and related coupling reactions.
    Organic & biomolecular chemistry, 2006, Nov-21, Volume: 4, Issue:22

    Topics: Crystallography, X-Ray; Cyclization; Heterocyclic Compounds, 4 or More Rings; Models, Molecular; Molecular Structure; Oxazoles; Stereoisomerism

2006
Oxidative rearrangement of indoles: a new approach to the EFHG-tetracyclic core of diazonamide A.
    The Journal of organic chemistry, 2007, Apr-13, Volume: 72, Issue:8

    Topics: Crystallography, X-Ray; Cyclization; Heterocyclic Compounds, 4 or More Rings; Indoles; Models, Molecular; Molecular Structure; Oxazoles; Oxidation-Reduction; Stereoisomerism; Tubulin Modulators

2007
An expedient formal total synthesis of (-)-diazonamide A via a powerful, stereoselective O-aryl to C-aryl migration to form the C10 quaternary center.
    Journal of the American Chemical Society, 2007, Oct-10, Volume: 129, Issue:40

    Topics: Animals; Heterocyclic Compounds, 4 or More Rings; Oxazoles; Stereoisomerism; Tyrosine; Urochordata

2007
Diazonamide support studies: stereoselective formation of the C10 chiral center in both the CDEFG and AEFG fragments.
    Organic letters, 2008, Sep-18, Volume: 10, Issue:18

    Topics: Benzofurans; Heterocyclic Compounds, 4 or More Rings; Indoles; Oxazoles; Oxindoles; Stereoisomerism; Substrate Specificity; Tyrosine

2008
A concise formal synthesis of diazonamide A by the stereoselective construction of the C10 quaternary center.
    Angewandte Chemie (International ed. in English), 2010, Mar-22, Volume: 49, Issue:13

    Topics: Antimitotic Agents; Heterocyclic Compounds, 4 or More Rings; Macrocyclic Compounds; Molecular Structure; Oxazoles; Stereoisomerism

2010
FeCl3-mediated Friedel-Crafts hydroarylation with electrophilic N-acetyl indoles for the synthesis of benzofuroindolines.
    Angewandte Chemie (International ed. in English), 2012, Dec-07, Volume: 51, Issue:50

    Topics: Antineoplastic Agents; Catalysis; Chlorides; Ferric Compounds; Heterocyclic Compounds, 4 or More Rings; Indoles; Oxazoles; Stereoisomerism

2012
Stereoselective synthesis of the diazonamide a macrocyclic core.
    The Journal of organic chemistry, 2015, Mar-20, Volume: 80, Issue:6

    Topics: Crystallography, X-Ray; Heterocyclic Compounds, 4 or More Rings; Macrocyclic Compounds; Models, Molecular; Molecular Structure; Oxazoles; Stereoisomerism

2015
Enantiocontrolled synthesis of a tetracyclic aminal corresponding to the core subunit of diazonamide A.
    The Journal of organic chemistry, 2015, Mar-20, Volume: 80, Issue:6

    Topics: Heterocyclic Compounds, 4 or More Rings; Molecular Conformation; Oxazoles; Stereoisomerism

2015
Connecting Tyrosine and Tryptophan Units of Diazonamide A and Azonazine by a Diastereodivergent Arylative Dearomatization.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2015, Dec-21, Volume: 21, Issue:52

    Topics: Catalysis; Dipeptides; Heterocyclic Compounds, 4 or More Rings; Indoles; Molecular Structure; Onium Compounds; Oxazoles; Pyrroles; Stereoisomerism; Tryptophan; Tyrosine

2015
Formal Total Synthesis of Diazonamide A by Indole Oxidative Rearrangement.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2016, Jul-25, Volume: 22, Issue:31

    Topics: Biological Products; Heterocyclic Compounds, 4 or More Rings; Indoles; Molecular Structure; Oxazoles; Oxidation-Reduction; Oxindoles; Stereoisomerism

2016
Interaction of diazonamide A with tubulin.
    Archives of biochemistry and biophysics, 2020, 02-15, Volume: 680

    Topics: Animals; Antineoplastic Agents; Cattle; Heterocyclic Compounds, 4 or More Rings; Oxazoles; Protein Binding; Protein Multimerization; Tubulin; Tubulin Modulators

2020