Compounds > oxazoles
Page last updated: 2024-08-21

oxazoles and conglobatin

oxazoles has been researched along with conglobatin in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's7 (77.78)24.3611
2020's2 (22.22)2.80

Authors

AuthorsStudies
Huang, W; Wu, QD; Xu, JH; Ye, M; Zhang, LR; Zhang, M; Zheng, W1
Cao, PR; Huang, W; Kong, YL; Wu, QD; Xu, JH; Ye, M; Zhang, M; Zheng, W1
Cao, HH; Chen, B; Chen, H; Du, ZP; Huang, W; Jia, W; Jiang, H; Li, EM; Li, LY; Liao, LD; Xie, JJ; Xie, YM; Xu, LY; Xu, XE; Zeng, FM; Zhang, YL; Zheng, W1
Dias, LC; Leadlay, PF; Murphy, AC; Prediger, P; Samborskyy, M; Zhou, Y1
Cao, P; Chen, L; Huang, W; Kong, Y; Luo, Y; She, B; Xu, J; Ye, M1
Abankwa, D; Aittokallio, T; Guzmán, C; Jaiswal, A; Lacey, E; Lectez, B; Najumudeen, AK; Oetken-Lindholm, C; Posada, IM; Siljamäki, E1
Fu, L; Li, P; Ma, C; Wu, M; Xu, J; Ye, S; Zhang, Z1
Booth, TJ; Chooi, YH; Lacey, E; Lacey, HJ; Piggott, AM; Rutledge, PJ; Vuong, D1
Chen, R; Cowled, MS; Lacey, E; Lacey, H; Piggott, AM; Rutledge, PJ; Vuong, D1

Other Studies

9 other study(ies) available for oxazoles and conglobatin

ArticleYear
FW-04-806 inhibits proliferation and induces apoptosis in human breast cancer cells by binding to N-terminus of Hsp90 and disrupting Hsp90-Cdc37 complex formation.
    Molecular cancer, 2014, Jun-14, Volume: 13

    Topics: Apoptosis; Breast Neoplasms; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Chaperonins; Female; HSP90 Heat-Shock Proteins; Humans; Macrolides; MCF-7 Cells; Multiprotein Complexes; Oxazoles; Protein Binding; Receptor, ErbB-2

2014
Novel Hsp90 inhibitor FW-04-806 displays potent antitumor effects in HER2-positive breast cancer cells as a single agent or in combination with lapatinib.
    Cancer letters, 2015, Jan-28, Volume: 356, Issue:2 Pt B

    Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Blotting, Western; Breast Neoplasms; Cell Proliferation; Drug Resistance, Neoplasm; Drug Synergism; Female; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Immunoenzyme Techniques; Lapatinib; Mice; Mice, Inbred BALB C; Mice, Nude; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Quinazolines; Real-Time Polymerase Chain Reaction; Receptor, ErbB-2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tumor Cells, Cultured; Xenograft Model Antitumor Assays

2015
Macrolide analog F806 suppresses esophageal squamous cell carcinoma (ESCC) by blocking β1 integrin activation.
    Oncotarget, 2015, Jun-30, Volume: 6, Issue:18

    Topics: Animals; Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Adhesion; Cell Line, Tumor; Cell Proliferation; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Humans; Integrin beta1; Male; Mice; Mice, Nude; Oxazoles; Random Allocation; Xenograft Model Antitumor Assays

2015
Iterative Mechanism of Macrodiolide Formation in the Anticancer Compound Conglobatin.
    Chemistry & biology, 2015, Jun-18, Volume: 22, Issue:6

    Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Cloning, Molecular; Escherichia coli; Genes, Bacterial; Magnetic Resonance Spectroscopy; Mass Spectrometry; Multigene Family; Oxazoles; Polyketide Synthases; Streptomyces

2015
[The Hsp90 inhibitor FW-04-806 suppresses Bcr/Abl-mediated growth of leukemia cells by inhibiting proliferation and inducing apoptosis].
    Zhonghua zhong liu za zhi [Chinese journal of oncology], 2015, Volume: 37, Issue:12

    Topics: Apoptosis; Cell Cycle; Cell Proliferation; Fusion Proteins, bcr-abl; HL-60 Cells; HSP90 Heat-Shock Proteins; Humans; K562 Cells; Leukemia; Membrane Potential, Mitochondrial; Oxazoles; RNA, Messenger; Signal Transduction

2015
Cancer stem cell drugs target K-ras signaling in a stemness context.
    Oncogene, 2016, 10-06, Volume: 35, Issue:40

    Topics: Calmodulin; Caveolae; Gene Expression Regulation, Neoplastic; Humans; MCF-7 Cells; Neoplasms; Neoplastic Stem Cells; Oxazoles; Proto-Oncogene Proteins p21(ras); Pyrans; ras Proteins; Sesterterpenes

2016
Reversal effect of FW-04-806, a macrolide dilactone compound, on multidrug resistance mediated by ABCB1 and ABCG2 in vitro and in vivo.
    Cell communication and signaling : CCS, 2019, 09-01, Volume: 17, Issue:1

    Topics: Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily G, Member 2; Cell Proliferation; Cells, Cultured; Dose-Response Relationship, Drug; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; HEK293 Cells; Humans; K562 Cells; KB Cells; Mice; Molecular Docking Simulation; Molecular Structure; Neoplasm Proteins; Neoplasms, Experimental; Oxazoles; Rhodamine 123; Signal Transduction; Structure-Activity Relationship

2019
Conglobatins B-E: cytotoxic analogues of the C
    The Journal of antibiotics, 2020, Volume: 73, Issue:11

    Topics: Cell Line, Tumor; Cytotoxins; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Oxazoles; Streptomyces

2020
Yeppoonic acids A - D: 1,2,4-trisubstituted arene carboxylic acid co-metabolites of conglobatin from an Australian Streptomyces sp.
    The Journal of antibiotics, 2022, Volume: 75, Issue:2

    Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antineoplastic; Australia; Carboxylic Acids; Cell Line, Tumor; Humans; Male; Mice; Multiple Myeloma; Oxazoles; Prostatic Neoplasms; Queensland; Soil Microbiology; Streptomyces

2022