oxazoles has been researched along with calyculin a in 895 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (0.56) | 18.7374 |
| 1990's | 409 (45.70) | 18.2507 |
| 2000's | 359 (40.11) | 29.6817 |
| 2010's | 115 (12.85) | 24.3611 |
| 2020's | 7 (0.78) | 2.80 |
| Authors | Studies |
|---|---|
| Schäfer, C; Wagner, AC; Williams, JA | 1 |
| Badwey, JA; Ding, J | 2 |
| Ariyoshi, H; Kambayashi, J; Kang, J; Kawasaki, T; Mori, T; Murata, K; Sakon, M; Shiba, E; Yukawa, M | 1 |
| Cao, X; Guy, GR; Mahendran, R; Tan, YH | 1 |
| Lerea, KM | 1 |
| Broquet, P; Geoffroy, J; George, P; Louisot, P; Reboul, P | 1 |
| Kuo, JF; Sakurada, K; Zheng, B | 1 |
| Allen, RE; Chartier, L; Fusetani, N; Hartshorne, DJ; Hirano, K; Karaki, H; Taylor, RG | 1 |
| Obara, K; Usuki, T; Yabu, H | 2 |
| Iguchi, A; Ishiguro, T; Miura, H; Nonogaki, K; Sakamoto, N; Tamagawa, T; Uemura, K | 1 |
| Armstrong, SC; Ganote, CE | 1 |
| Brautigan, DL; Eriksson, JE; Fujiki, H; Goldman, RD; Olmsted, J; Vallee, R | 1 |
| Keller, H; Kreienbühl, P; Niggli, V | 1 |
| Deguchi, K; Ito, M; Kobayashi, K; Kuno, T; Morita, K; Nagao, M; Nakano, T; Nishikawa, M; Shima, H; Tanaka, C | 1 |
| Chubb, CH; Fujiki, H; Giometti, C; Huberman, E; Kiguchi, K | 1 |
| Goad, DL; Meurer, EA; Petrou, CP; Tashjian, AH; Voelkel, EF | 1 |
| Barros, F; de la Peña, P; del Camino, D; Delgado, LM | 1 |
| Fusetani, N; Mabuchi, I; Nakazawa, T; Tosuji, H | 1 |
| Chen, ZH; Gopalakrishna, R; Gundimeda, U | 1 |
| Fujiki, H; Furuya, H; Matsunaga, S; Matsushima, R; Nishiwaki, S; Okabe, S; Suganuma, M; Sugimura, T; Yatsunami, J; Yoshizawa, S | 1 |
| Han, YG; Hartshorne, DJ; Hori, M; Karaki, H; Magae, J | 1 |
| Blondfield, DP; Fusetani, N; Ozaki, H; Publicover, NG; Sanders, KM; Uemura, D; Vogalis, F; Ward, SM | 1 |
| Carl, A; Fusetani, N; Kenyon, JL; Sanders, KM; Uemura, D | 1 |
| Fusetani, N; Karaki, H; Obara, K; Ozaki, H; Someya, T; Usuki, T; Yabu, H | 1 |
| Fujiki, H; Nishiwaki, S; Suganuma, M; Sugimura, T; Winyar, B; Yoshizawa, S | 1 |
| Garrison, JC; Mattingly, RR | 1 |
| Higuchi, H; Hiraoka, N; Ito, M; Itoh, H; Konishi, T; Lederis, K; Nakano, T | 1 |
| Allen, RE; Chartier, L; Fusetani, N; Hartshorne, DJ; Karaki, H; Kato, Y; Rankin, LL; Watabe, S | 1 |
| Cohen, P; Holmes, CF; Tsukitani, Y | 1 |
| Fujiki, H; Furuya-Suguri, H; Fusetani, N; Kato, Y; Suganuma, M; Sugimura, T; Yasumoto, S; Yoshizawa, S | 1 |
| Cohen, P | 1 |
| Fujiki, H; Nishiwaki, S; Schmitz, FJ; Suganuma, M; Sugimura, T; Winyar, B; Yoshizawa, S | 1 |
| Karaki, H; Obara, K; Ozaki, H; Someya, T; Usuki, T; Yabu, H; Yoshino, M | 1 |
| Fusetani, N; Hashimoto, K; Kato, Y; Matsunaga, S | 1 |
| Brautigan, DL; Fusetani, N; Hashimoto, K; Ishihara, H; Karaki, H; Kato, Y; Martin, BL; Ozaki, H; Uemura, D; Watabe, S | 1 |
| Fusetani, N; Hashimoto, K; Hori, M; Ishihara, H; Karaki, H; Kato, Y; Ozaki, H; Sato, K; Uemura, D; Watabe, S | 1 |
| Ohara, K; Someya, T; Usuki, T; Yabu, H | 1 |
| Karaki, H; Ohara, K; Ozaki, H; Someya, T; Usuki, T; Yabu, H | 1 |
| Bize, I; Dunham, PB | 2 |
| Bajpai, A; Brahmi, Z | 3 |
| Belandia, B; Cuadrado, MA; Delgado, MD; León, J; Lerga, A; Martín-Perez, J; Ortiz, JM; Richard, C | 1 |
| Ishibashi, S; Okamura, N; Saeki, S; Yamaguchi, M; Yamane, H | 2 |
| Arima, S; Inokoshi, J; Katagiri, M; Matsuzaki, K; Omura, S; Tanaka, H | 1 |
| Ashizawa, K; Magome, A; Tsuzuki, Y | 1 |
| Fontana, A; Groscurth, P; Malipiero, U; Weller, M | 1 |
| Azzi, A; Boscoboinik, D; Latruffe, N | 1 |
| Boddeke, H; Figurov, A; Muller, D | 1 |
| Deery, WJ | 1 |
| Fetz, I; Fölsch, UR; Höcker, M; Kern, HF; Meyer-Alber, A; Schmidt, WE; Waschulewski, IH | 1 |
| Glaum, SR; Miller, RJ | 1 |
| Fetz, I; Fölsch, UR; Höcker, M; Meyer-Alber, A; Schmidt, WE; Waschulewski, IH | 1 |
| Grant, K; Ma, TY; Said, HM | 1 |
| García-Sáinz, JA; González-Espinosa, C | 1 |
| Bruder, JT; Geppert, TD; Owaki, H; Rapp, UR; Whitehurst, CE | 1 |
| Chik, CL; Ho, AK | 1 |
| Fetz, I; Fölsch, UR; Fornefeld, H; Höcker, M; Meyer-Alber, A; Schmidt, WE; Waschulewski, IH | 1 |
| Chang, F; Cohen, IS; Yu, H | 2 |
| Chik, CL; Ho, AK; Karpinski, E; Kovacs, CS; Li, B | 1 |
| Hashikawa, T; Ito, M; Mikawa, S; Nakazawa, K | 1 |
| An, B; Dou, QP; Will, PL | 1 |
| Berndt, N; Kaplowitz, N; Runnegar, M | 1 |
| Berg, T; Berg, TO; Brech, A; Fengsrud, M; Gordon, PB; Holen, I; Roos, N; Seglen, PO; Strømhaug, PE | 1 |
| Jordan, NJ; Watson, ML; Westwick, J | 1 |
| Bøe, R; Døskeland, SO; Gjertsen, BT; Vintermyr, OK | 1 |
| Dou, QP; Lui, VW | 1 |
| Huang, CY; Qin, K; Santini, F; Wang, Y | 1 |
| Bijman, J; de Jonge, HR; Edixhoven, M; French, PJ; Lohmann, SM; Nairn, AC; Scholte, BJ; Vaandrager, AB | 1 |
| Guild, SB; McFerran, BW | 1 |
| Del Castillo, JR; Sepúlveda, FV | 1 |
| Herzig, S; Meier, A; Neumann, J; Pfeiffer, M | 1 |
| Hoyt, CH; Lerea, KM | 1 |
| Ballard, D; Chen, Z; Hagler, J; Maniatis, T; Melandri, F; Palombella, VJ; Scherer, D | 1 |
| Harhaj, E; Maggirwar, SB; Sun, SC | 1 |
| Day, MA; Garcia, JG; Patterson, CE; Verin, AD | 1 |
| Hasegawa, H; Kurihara, K; Matsumoto, R; Minami, N; Nakanishi, N; Onozawa, S; Ueha, T | 1 |
| Barber, SA; McNally, R; Perera, PY; Vogel, SN | 1 |
| Chen, J; Cohn, JA; Mandel, LJ | 1 |
| Carriger, ML; Malphurs, WL; Vickroy, TW | 1 |
| Marantz, Y; Naor, Z; Przedecki, F; Reiss, N | 1 |
| Chong, AS; Curry, MS; Edwards, BS; Graf, LH; Southon, EA | 1 |
| Haneji, T; Kobayashi, S; Murata, T; Shirakawa, S; Takehara, T | 1 |
| Elsner-Menzel, C; Frank, S; Menzel, D; Vugrek, O | 1 |
| Ichida, T; Kanazawa, M; Okumura, K; Takuma, T | 1 |
| Eyster, KM; Johnson, MJ; Miller, CJ; Miller, TL; Persing, JS; Waller, MS | 1 |
| Danenberg, K; Danenberg, PV; Lenz, HJ; Scavetta, R; Schönthal, AH; Wang, SJ | 1 |
| Cressey, LI; Døskeland, SO; Gjertsen, BT; Houge, G; Lanotte, M; Ruchaud, S | 1 |
| Berndt, N; Deleve, LD; Govindarajan, S; Maddatu, T; Runnegar, MT | 1 |
| Combadière, C; Djerdjouri, B; Hakim, J; Pedruzzi, E; Périanin, A | 1 |
| Hase, T; Kambayashi, J; Mori, T; Murata, K; Okuyama, M; Sakon, M | 1 |
| Andexinger, S; Lohse, MJ; Pippig, S | 1 |
| Kambayashi, J; Kawasaki, T; Sakon, M; Senda, T; Shibata, N; Tanaka, K; Yamada, F; Yano, Y | 1 |
| Aggarwal, BB; Singh, S | 1 |
| Bouron, A; Reber, BF | 1 |
| Henderson, LK; Matthews, N; Nemec, M; Southern, C; Thorp, KM; Wilkinson, PC | 1 |
| Ajima, A; Ito, M | 1 |
| Bond, M; Damron, DS; Darvish, A; Moravec, CS; Murphy, L; Sweet, W | 1 |
| Abayasekara, RE; Ford, SL; Jones, PM; Persaud, SJ | 1 |
| Imanaga, I; Inoue, M | 1 |
| Hirsch, J; Schlatter, E | 1 |
| Gibson, JS; Hall, AC | 1 |
| Breittmayer, JP; Frelin, C; Vigne, P | 1 |
| Bartel, S; Bokník, P; Kaspareit, G; Krause, EG; Neumann, J; Pask, HT; Schmitz, W; Scholz, H | 1 |
| Papasozomenos, SC; Su, Y | 1 |
| Brumell, JH; Grinstein, S | 1 |
| Morimoto, K; Nakajima, M; Takeuchi, T | 1 |
| Jochum, C; Mayer, P; Pfeiffer, A; Schatz, H | 1 |
| Okuyama, A; Someya, A; Tanaka, N | 2 |
| Gutiérrez, LM; Quintanar, JL; Reig, JA; Sala, F; Viniegra, S | 1 |
| Assmann, SM; Li, W; Luan, S; Schreiber, SL | 1 |
| Matsuyama, S; Murakami, N; Nei, K; Saito, N; Sakai, N; Tanaka, C | 1 |
| Mumby, MC; Nagao, M; Nakai, K; Nishikawa, M; Ogasawara, H; Omay, SB; Shiku, H; Shima, H; Toyoda, H | 1 |
| Hunchuk, N; Li, XB; Wong, K | 1 |
| Borgese, F; Garcia-Romeu, F; Guizouarn, H; Motais, R; Pellissier, B | 1 |
| Cossins, AR; Ellory, JC; Gibson, JS; Godart, H; Honess, NA; Staines, H | 1 |
| Pshenichkin, SP; Wise, BC | 1 |
| Johnston, JA; Silver, RB; Sloboda, RD | 1 |
| Aguilera, RJ; Casillas, AM; Cheshier, S; Hernandez, S; Thompson, AD | 1 |
| Volz, A | 1 |
| Nicoll, RA; Wyllie, DJ | 1 |
| Kao, LS; Lin, LF; Westhead, EW | 1 |
| Herron, CE; Malenka, RC | 1 |
| Baldo, GJ; Cohen, IS; Gao, J; Mathias, RT | 2 |
| Kobryn, CE; Mandel, LJ | 1 |
| Koch, B; Lutz-Bucher, B | 1 |
| Cressey, LI; Døskeland, SO; Gjertsen, BT; Gliemann, J; Hokland, P; Jensen, PH; Lanotte, M; Madsen, P; Mellgren, G; Vintermyr, OK | 1 |
| Aoki, M; Matsuyama, S; Nishihara, M; Takahashi, M; Yamanouchi, K; Yamanouchi, S | 1 |
| Kleinhaus, AL; Zeman, RJ | 1 |
| Mizuno, M; Packer, L; Suzuki, YJ | 1 |
| Bokník, P; Herzig, S; Neumann, J; Schmitz, W; Scholz, H; Wiechen, K; Zimmermann, N | 1 |
| Alverez, J; Garcia-Sancho, J; Montero, M | 1 |
| Mills, I; Murata, K; Packer, CS; Sumpio, BE | 1 |
| Bai, G; Lee, EY; Long, F; Nagao, M; Shima, H; Zhang, L; Zhang, Z; Zhao, S | 1 |
| Deguchi, K; Kuno, T; Morita, K; Nagao, M; Nishikawa, M; Saito, M; Shima, H; Shirakawa, S; Tawara, I; Toyoda, H | 1 |
| Boynton, AL; Codispoti, BA; Honkanan, RE; Honkanen, RE; Tse, K | 1 |
| Koike, Y; Kume, S; Kurota, K; Ozaki, Y; Qi, R; Satoh, K; Yatomi, Y | 1 |
| Goings, GE; Hanck, DA; Page, E; Upshaw-Earley, J | 1 |
| Athlan, ES; Mushynski, WE; Sacher, MG | 1 |
| Murphy, CT; Westwick, J | 1 |
| Frelin, C; Lopez Farre, A; Vigne, P | 1 |
| Giebisch, G; Hebert, SC; Ho, K; McNicholas, CM; Wang, W | 1 |
| Ashizawa, K; Nishinakama, K; Tomonaga, H; Tsuzuki, Y; Wishart, GJ | 1 |
| Bollen, M; De Smedt, H; Himpens, B | 1 |
| Dunham, PB; Haas, M; Rao, MC; Suvitayavat, W | 1 |
| Chu, FS; Lin, JR | 1 |
| Chambers, TC; Kuo, JF; Raynor, RL | 1 |
| Kawasaki, K; Shinohara, S | 1 |
| Bona, BJ; Moyer, ML; Nordeen, SK | 1 |
| Sakamoto, N; Shuntoh, H; Tanaka, C | 1 |
| Antoku, S; Nakamura, K | 1 |
| Brautigan, DL; MacDonald, JF; Orser, BA; Wang, LY | 1 |
| Finbloom, DS; Luong, H; Winestock, KD | 1 |
| Mariash, CN; Sudo, Y | 1 |
| Berggren, PO; Honkanen, RE; Sjöholm, A | 1 |
| Ishibashi, S; Kuwana, M; Okamura, N; Sakai, M; Sasaki, J; Yamaguchi, M | 1 |
| Gali, RR; Khandelwal, RL; Pugazhenthi, S; Yu, B | 1 |
| Hartshorne, DJ; Hosoya, N; Ishihara, H; Karaki, H; Mitsui, M; Mohri, H; Ozaki, H; Yazama, F | 1 |
| Husøy, T; Mikalsen, SO; Sanner, T | 1 |
| Sheen, J | 1 |
| Larrick, JW; Torti, FM; Wright, SC; Zheng, H; Zhong, J | 1 |
| Afar, DE; Almazan, G; Bell, JC | 1 |
| Iwata, M; Mukai, M; Nakai, Y; Ohoka, Y | 1 |
| Hartshorne, DJ; Hirano, K | 1 |
| Iwata, H; Nakanishi, H; Suganuma, M; Tatematsu, M; Yoshida, K; Yuasa, H | 1 |
| Favre, B; Hemmings, BA; Kiefer, B; Lee, JS; Nagamine, Y | 1 |
| Dunham, PB; Haas, M; Kalmar, F; Palfrey, HC; Rao, MC; Suvitayavat, W | 1 |
| Alvarez, J; García-Sancho, J; Montero, M | 1 |
| Palfrey, HC; Pewitt, EB | 1 |
| Endo, Y; Furuya, S; Nozawa, S; Oba, M; Osumi, K; Suzuki, S | 1 |
| Lavin, MF; Song, Q | 1 |
| Jennings, ML; Starke, LC | 1 |
| Brenner, HR; Britt, JC; Caroni, P; Rotzler, S | 1 |
| Obara, K; Yabu, H | 1 |
| Fukunaga, K; Miyamoto, E; Muller, D; Stoppini, L | 1 |
| Bøe, R; Døskeland, SO; Mellgren, G; Vintermyr, OK | 1 |
| Chan, CK; Downey, GP; Grinstein, S; Takai, A; Zamel, R | 1 |
| Fujitani, K; Kambayashi, J; Kawasaki, T; Mori, T; Murata, K; Sakon, M; Shiba, E; Yano, Y; Yukawa, M | 1 |
| Gordon, PB; Holen, I; Seglen, PO | 1 |
| Elmslie, KS; Jones, SW; Overholt, JL; Werz, MA | 1 |
| Herron, CE; Malenka, RC; Mulkey, RM | 1 |
| Itoh, T; Suzuki, A | 1 |
| Fujitani, K; Kambayashi, J; Kawasaki, T; Mori, T; Murata, K; Sakon, M; Shiba, E; Uemura, Y; Yano, Y | 1 |
| Kuo, JF; Noland, TA; Raynor, RL; Venema, RC | 1 |
| Kennelly, PJ; Oxenrider, KA; Rasche, ME; Thorsteinsson, MV | 1 |
| James, DE; Lawrence, JC; Robinson, LJ; Robinson, R | 1 |
| Hosoi, K; Kurihara, K; Ueha, T | 1 |
| Gundersen, GG; Gurland, G | 1 |
| Klein, JD; O'Neill, WC; Perry, PB | 1 |
| Bengis-Garber, C; Gruener, N | 1 |
| da Cruz e Silva, EF; da Cruz e Silva, OA; Greengard, P; Zaia, CT | 1 |
| Bullock, AJ; Murphy, CT; Westwick, J | 1 |
| Gutierrez, LM; Quintanar, JL; Reig, JA; Rueda, J; Viniegra, S | 1 |
| Chen, G; Gao, XM; Newell, SW; Perchellet, EM; Perchellet, JP | 1 |
| Fujitani, K; Ikeda, M; Kambayashi, J; Kawasaki, T; Monden, M; Oiki, E; Okuyama, M; Sakon, M; Shinoki, N; Yano, Y | 1 |
| Hartshorne, DJ; Kurisaki, T; Taylor, RG | 1 |
| Bravo, R; Claudio, E; Lazo, PS; Ramos, S; Segade, F; Wrobel, K | 1 |
| Azzi, A; Bartoli, GM; Boscoboinik, D; Maroni, P; Tasinato, A | 1 |
| Handschumacher, RE; Li, W | 1 |
| Khan, IA; Ludueña, RF | 1 |
| Dunham, PB; Krarup, T | 1 |
| Wright, SC; Zheng, H; Zhong, J | 1 |
| Hernández, ML; López de Heredia, M; Martínez, MJ; Ochoa, B | 2 |
| Kessel, D; Luo, Y | 1 |
| Good, LF; Kealiher, A; Maggirwar, SB; Sun, SC; Uhlik, M | 1 |
| Cossins, AR; Gibson, JS; Honess, NA | 1 |
| Amano, M; Chihara, K; Feng, J; Fukata, Y; Ito, M; Iwamatsu, A; Kaibuchi, K; Kimura, K; Nakafuku, M; Nakano, T; Okawa, K; Yamamori, B | 1 |
| Dunwiddie, TV; Frazier, CJ; Harris, RA; Kazlauskas, A; MacDonald, JF; Valenzuela, CF; Weiner, JL; Whiting, PJ; Xiong, Z | 1 |
| Cronstein, BN; Landau, S; Montesinos, MC; Naime, D; Revan, S | 1 |
| Brown, MK; Eastman, A; Li, J; Morana, SJ; Reynolds, JE; Wolf, CM | 1 |
| Beresini, MH; Dhawan, P; Kumar, A; Mehta, KD | 1 |
| Chock, PB; Huang, CY; Tekle, E; Zhu, DM | 1 |
| Comolli, J; Hastings, JW; Rehman, J; Taylor, W | 1 |
| Lambert, IH; Mollerup, J | 2 |
| Bieger, D; Martin-Caraballo, M; Triggle, CR | 1 |
| Hartzell, HC; Petit-Jacques, J | 1 |
| Baum, L; Kawabata, S; Koyama, M; Maruyama, K; Saitoh, T; Seger, R; Silver, J; Woodgett, JR | 1 |
| Bragado, MJ; Duan, RD; Hwang, J; Williams, JA | 1 |
| Barber, SA; Detore, G; McNally, R; Vogel, SN | 1 |
| Adragna, NC; Flatman, PW; Lauf, PK | 1 |
| Ambudkar, IS; Sakai, T | 1 |
| Cossins, AR; Weaver, YR | 1 |
| Dam, A; Raman, S; Reenstra, WW; Shorten, S; Yurko-Mauro, K | 1 |
| Nagao, T; Urushidani, T | 1 |
| Hirsch, JR; Loo, DD; Sarkar, HK; Wright, EM | 1 |
| Forbush, B; Lytle, C | 1 |
| Jennings, ML; Namboodiripad, AN | 1 |
| Collier, B; Gauthier, S; Issa, AM | 3 |
| Hedman, H; Lundgren, E | 1 |
| Patzlaff, JS; Paulson, JR; Vallis, AJ | 1 |
| Abe, H; Obinata, T; Okada, K; Takano-Ohmuro, H | 1 |
| Iuorno, J; Weeks, BS | 1 |
| Chen, KC; Huang, HH; Kao, YT; Lin, CG; Lin, HC; Liu, WT; Wang, TM | 1 |
| Barbier, J; Begon, F; Kraimps, JL; Métayé, T; Sarrouilhe, D | 1 |
| Dales, S; Kalicharran, K | 1 |
| Amieva, MR; Furthmayr, H; Hirota, C; Mizuno, Y; Nakamura, F | 1 |
| da Cruz e Silva, EF; Greengard, P; Khatra, B; Smith, GD; Stephens, DT; Trautman, K; Vijayaraghavan, S | 1 |
| da Cruz e Silva, EF; Greengard, P; Smith, GD; Trautman, KC; Vijayaraghavan, S; Wolf, DP | 1 |
| Armstrong, SC; Delacey, MH; Ganote, CE; Hoover, DB | 1 |
| Boudreaux, JM; Newberry, EP; Towler, DA | 1 |
| Ichida, T; Obinata, T; Takuma, T; Tamura, S; Yokoyama, N | 1 |
| Abayasekara, DR; Ford, SL; Jones, PM; Persaud, SJ | 2 |
| Blenis, J; Monfar, M | 1 |
| Munday, MR; Peachell, PT; Peirce, MJ; Warner, JA | 1 |
| Marriott, I; Mason, MJ | 1 |
| Fukunaga, K; Kano, M; Konnerth, A | 1 |
| Dales, S; Kalicharran, K; Mohandas, D; Wilson, G | 1 |
| Gilbert, LI; Song, Q | 1 |
| Dunham, PB; Kelley, SJ | 1 |
| Cesare, P; McNaughton, P | 1 |
| Albrecht, FE; Aoki, Y; Bergman, KR; Jose, PA | 1 |
| Chueh, SH; Ho, MY; Hu, SY; Song, SL | 1 |
| Harris, RA; Huidobro-Toro, JP; Valenzuela, CF | 1 |
| Haneji, T; Kobayashi, S; Morimoto, Y; Ohba, T | 1 |
| Bagu, JR; Craig, MM; Holmes, CF; Sykes, BD | 1 |
| Grocholová, R; Jílek, F; Petr, J; Rozinek, J | 1 |
| Harhaj, EW; Sun, SC | 1 |
| Cheng, TH; Hwang, TC; Price, EM; Wang, F; Yang, IC | 1 |
| Cunningham, A; Lazo, JS; Rice, RL; Wipf, P | 1 |
| Duclos, B; Durocher, Y; Grangeasse, C; Haftek, M; Schmitt, D; Serres, M | 1 |
| Chen, JS; Fong, TH; Hsu, SY; Lim, SS; Wang, SM | 1 |
| Arruda, JA; Cardoso, LR; Qiu, YY; Ruiz, OS | 1 |
| Israël, A; Laurent-Winter, C; Weil, R | 1 |
| Sawai, T | 1 |
| Choi, Y; Greengard, P; Kwon, YG; Lee, SY; Nairn, AC | 1 |
| Diaz, J; Kaji, DM; Parker, JC | 1 |
| Kamath, AM; Kamath, JM; Moy, AB; Ries, D; Shasby, DM; Shasby, SS; Stevens, T | 1 |
| Begg, AC; Coco-Martin, JM | 1 |
| Keller, H; Niggli, V | 1 |
| Berenbrink, M; Cossins, AR; Weaver, YR | 1 |
| Favre, B; Hemmings, BA; Turowski, P | 1 |
| Accili, EA; DiFrancesco, D; Redaelli, G | 1 |
| Honda, S; Ikegaki, N; Nakashita, M; Saito, N; Sakai, N; Sasaki, K | 1 |
| Asakawa, Y; Gotoh, E | 1 |
| Diwan, AH; Honkanen, RE; Schaeffer, RC; Strada, SJ; Thompson, WJ | 1 |
| Lytle, C | 2 |
| Cousin, JM; Haslett, C; Rossi, AG | 1 |
| Chang, MS; Chen, SA; Chiang, CE; Lin, CI; Luk, HN | 1 |
| Amano, K; Hori, M; Karaki, H; Ozaki, H; Sato, K | 1 |
| Lee, VM; Merrick, SE; Trojanowski, JQ | 1 |
| Ang, KL; Antaraki, A; Antoni, FA | 1 |
| Marwitz, J; Opitz, R; Quentin, I; Ritz, V; Steinfelder, HJ; Tergau, F; von Zezschwitz, C; Weichert, J | 1 |
| Blaukat, A; Müller-Esterl, W | 1 |
| Chen, JG; Cheng, G; Randić, M; Sandkühler, J | 1 |
| Pinna, C; Rossini, GP; Viviani, R | 1 |
| Hayakawa, T; Kogi, M; Oshizawa, T; Yamaguchi, T | 1 |
| Amzil, Z; James, KJ; Marcaillou-Le Baut, C; Pouchus, YF; Verbist, JF | 1 |
| Lawrence, JC; Lin, TA | 1 |
| Imanaga, I; Inoue, M; Sakamoto, Y; Yano, A | 1 |
| Ha, KS; Jung, HI; Kang, KW; Park, YM; Shin, I | 1 |
| Kwan, CY; Leung, YM; Loh, TT | 1 |
| Chen, J; Mandel, LJ | 1 |
| Steinfelder, HJ; Tergau, F; von Zezschwitz, C; Vorwerk, H | 1 |
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| Aranson, IS; Ziebert, F | 1 |
| Barquinero, JF; Barrios, L; Caballín, MR; Puig, R; Pujol, M | 1 |
| Di Carlo, D; Dudani, JS; Gossett, DR; Tse, HT | 1 |
| Konstantopoulos, K; Paul, CD; Raman, PS; Stroka, KM | 1 |
| Chen, L; Chen, S; Chen, X; Du, Q; Han, W; Li, Y; Olumi, AF; Qian, X; Ruan, A; Wang, R; Wang, X; Yang, H; Zhang, X | 1 |
| Jerrell, RJ; Parekh, A | 1 |
| Burbiel, JC; Bylund, J; Christenson, K; Dahlgren, C; Forsman, H; Gabl, M; Müller, CE; Önnheim, K; Oprea, TI | 1 |
| Abe, M; Hamamura, Y; Higashiyama, T; Iwano, M; Kanaoka, MM; Kawarazaki, T; Kaya, H; Kimura, S; Kuchitsu, K; Nakajima, R; Senzaki, E; Takayama, S; Takeda, S | 1 |
| Cooper, EC; Hoshi, N; Kang, S; Xu, M | 1 |
| Gray, EE; Guglietta, R; Khakh, BS; O'Dell, TJ | 1 |
| Abid, MD; Chen, J; Feng, Z; Huang, H; Liu, X; Wan, L; Yan, H; Zhou, J | 1 |
| Abe, Y; Blakely, WF; Kasai, K; Miura, T; Nakano, M; Nakata, A; Ossetrova, NI; Tsushima, E; Yoshida, MA | 1 |
| Ghassem-Zadeh, SA; Lee, J; Morin, TR | 1 |
| Bertling, E; Hotulainen, P; Hotulainen, R; Koskinen, M; Tanhuanpää, K | 1 |
| Craig, RW; Kasof, G; Nifoussi, SK; Ornstein, DL; Ratcliffe, NR; Strack, S | 1 |
| Abe, I; Asakawa, Y; Awakawa, T; Egami, Y; Ito, T; Kenmoku, H; Mori, T; Nakashima, Y; Piel, J; Wakimoto, T; Wakimoto, Y | 1 |
| Basilicata, MF; Bertamino, A; Campiglia, P; Ciccarelli, M; De Luca, N; Iaccarino, G; Illario, M; Rusciano, MR; Santulli, G; Sorriento, D; Trimarco, B | 1 |
| Balskus, EP | 1 |
| Filgueira, FP; Giachini, FR; Lima, VV; Lobato, NS; Tostes, RC; Webb, RC | 1 |
| D'Orazi, G; Garufi, A | 1 |
| Carey, GB; Daino, H; Roy, SK | 1 |
| Haga, H; Ishihara, S; Kawabata, K; Mizutani, T; Takemoto, K | 1 |
| Arai, MM; Fukushima, M; Harayama, H; Isono, A; Kojima, A; Mizuno, Y; Noda, T; Sakase, M | 1 |
| Langston, JW; Molitor, TP; Nichols, RJ; Zhao, J | 1 |
| Amado, IF; Amireault, P; Avery, VM; Buffet, PA; Chartrel, N; Duez, J; El Nemer, W; Français, O; Garcia, S; Holleran, JP; Lavazec, C; Le Pioufle, B; Le Van Kim, C; Loganathan, S; Ndour, PA | 1 |
| Ahammad, RU; Amano, M; Hamaguchi, T; Kaibuchi, K; Nakamuta, S; Nishioka, T; Shohag, MH; Yura, Y | 1 |
| Kang, SH; Kim, I; Kim, SY; Lee, HA; Seok, YM; Song, MJ | 1 |
| Demetriades, C; Plescher, M; Teleman, AA | 1 |
| Atmaca, H; Bozkurt, E; Erdogan, AP; Gursoy, P; Karaca, B; Şanlı, UA; Sezgin, C; Surmeli, Z; Uslu, R; Uzunoglu, S | 1 |
| Døskeland, SO; Herfindal, L; Kleppe, R | 1 |
| Haghparast, SM; Miyake, J; Tachibana, K | 1 |
| Foss, KM; Kornbluth, S; Robeson, AC; Zhang, L | 1 |
| Attieh, R; Dbaibo, G; El-Hed, AF; Hage-Sleiman, R; Hamze, AB; Kabbani, S; Kozhaya, L | 1 |
| Abe, I; Egami, Y; Wakimoto, T | 1 |
| Irani, S; Matthews, WL; Mayfield, J; Nie, G; Prescott, NA; Yogesha, SD; Zhang, M; Zhang, Y; Zhang, YJ | 1 |
| Günther, T; Kliewer, A; Lehmann, A; Nagel, F; Schulz, S | 1 |
| Abe, M; Goto, T; Hagiwara, M; Hosoya, T; Ikura, T; Ito, N; Kato-Sumida, T; Kii, I; Koike, Y; Nonaka, Y; Okuno, Y; Shibuya, H; Sonamoto, R; Sumida, Y; Yoshida, S | 1 |
| Breitbart, H; Shabtay, O | 1 |
| Efe, O; Ilori, TO; Klein, JD; Ren, H; Ruiz, JA; Sands, JM; Yang, B | 1 |
| Chen, DQ; Feng, JB; Liu, QJ; Lu, X; Zhao, H; Zhao, XT | 1 |
| B K, S; Bhat, NN; Desai, U; K Chaurasia, R; Nairy, RK; Shirsath, K; Yadav, U; Yerol, N | 1 |
| Almasry, M; Faggio, C; Jemaà, M; Lang, F; Mischitelli, M | 1 |
| Gotoh, T; Hirotani, K; Hiyama, E; Iida, H; Inai, T; Tsukamoto, M | 1 |
| Britt, WJ; Djinović-Carugo, K; Hartl, M; Kastner, MT; Majdic, O; Puchinger, MG; Rieder, FJJ; Schneider, M; Steininger, C | 1 |
| Chen, Y; Cheng, YC; Hsieh, CH; Hueng, DY; Tsai, WC | 1 |
| Chen, K; Chen, L; Gao, Y; Huang, H; Li, S; Liu, F; Wang, W; Xie, M; Xue, S; Zhang, M | 1 |
| Bátori, R; Bécsi, B; Bordán, Z; Erdődi, F; Hegedűs, C; Kónya, Z; Lontay, B; Nagy, D; Verin, A | 1 |
| Chagnon-Lessard, S; Godin, M; Jean-Ruel, H; Pelling, AE | 1 |
| Beke Debreceni, I; Clemetson, KJ; Csernoch, L; Erdődi, F; Hudák, R; Kappelmayer, J; Oláh, T; Vincze, J | 1 |
| Biondi, RM; Brieger, A; Hinrichsen, I; Huhn, M; Passmann, S; Plotz, G; Weßbecher, IM; Zeuzem, S | 1 |
| Chiba, Y; Ikebe, M; Kai, Y; Sakai, H; Sato, K | 1 |
| Chen, F; Gong, CX; Gu, J; Hu, W; Iqbal, K; Liu, F; Miao, S; Wang, W; Wu, F | 1 |
| Fabbrizi, MR; Hallahan, DE; Meyer, B; Misri, S; Raj, S; Sharma, GG; Zobel, CL | 1 |
| Piel, J; Uria, AR; Wakimoto, T | 1 |
| Just, S; Köhler, D; Pott, A; Pylatiuk, C; Rottbauer, W; Shahid, M; Weinmann, K | 1 |
| Hozaki, M; Matsumoto, T; Mizutani, E; Nakamura, M; Sugita, S | 1 |
| Baker, BM; Davidson, CD; Lin, D; Wang, WY | 1 |
| Paul, CD; So, WY; Staunton, JR; Tanner, K | 1 |
| Forer, A; Kite, E | 1 |
| Ainsbury, E; Barnard, S; Lloyd, D; Moquet, J; Sun, M | 1 |
| Du, H; Shi, J; Wang, Y; Wu, B; Zeng, Y; Zhao, J; Zhao, W | 1 |
| Ainsbury, E; Lloyd, D; Moquet, J; Sun, M | 1 |
| Balaban, PM; Maltsev, AV | 1 |
| Belyaev, I; Durdík, M; Marková, E; Míšek, J; Petrovičová, P; Račková, A; Zastko, L | 1 |
| Iida, H; Inai, T; Iwamori, N; Iwamori, T; Kaneko, T; Ogata, H; Takahashi, H; Tsukamoto, M; Yamashita, K | 1 |
14 review(s) available for oxazoles and calyculin a
| Article | Year |
|---|---|
Specific mechanistic aspects of animal tumor promoters: the okadaic acid pathway.
Topics: Animals; Antifungal Agents; Carcinogens; Ethers, Cyclic; Liver Neoplasms; Marine Toxins; Mice; Molecular Structure; Okadaic Acid; Oxazoles; Peptides, Cyclic; Pyrans; Rats; Skin Neoplasms; Spiro Compounds; Stomach Neoplasms; Structure-Activity Relationship | 1992 |
Okadaic acid: a new probe for the study of cellular regulation.
Topics: Animals; Carcinogens; Cell Extracts; Cells; Diarrhea; Ethers, Cyclic; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Shellfish Poisoning | 1990 |
The structure and regulation of protein phosphatases.
Topics: Animals; DNA; Enzyme Activation; Ethers, Cyclic; Fungal Proteins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Processing, Post-Translational; Second Messenger Systems; Structure-Activity Relationship; Subcellular Fractions | 1990 |
[Naturally occurring toxins with specific inhibitory activity against protein serine/threonine phosphatases 1 and 2A].
Topics: Alkenes; Animals; Antifungal Agents; Cantharidin; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Polyenes; Pyrans; Pyrones; Spiro Compounds | 1998 |
[Tumor promotion by inhibitors of protein phosphatase 1 and 2A].
Topics: Animals; Antifungal Agents; Marine Toxins; Microcystins; Neoplasms, Experimental; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 1; Pyrans; Spiro Compounds | 1998 |
Regulation of Na-K-2Cl cotransport by phosphorylation and protein-protein interactions.
Topics: Adenosine Triphosphate; Animals; Cell Membrane; Cell Size; Cells, Cultured; Chlorides; Cytoskeleton; Enzyme Inhibitors; Epithelium; Erythrocytes; Ion Transport; Marine Toxins; Oxazoles; Phosphorylation; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proteins; Sodium-Potassium-Chloride Symporters | 2002 |
G2 chromatid damage and repair kinetics in normal human fibroblast cells exposed to low- or high-LET radiation.
Topics: Animals; Cells, Cultured; CHO Cells; Chromatids; Chromosome Aberrations; Chromosome Breakage; Chromosomes, Human; Cricetinae; Cricetulus; DNA Repair; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Fibroblasts; G2 Phase; Gamma Rays; Humans; Kinetics; Linear Energy Transfer; Lymphocytes; Marine Toxins; Neutrons; Oxazoles; Phosphoprotein Phosphatases | 2004 |
Bioactive natural products from marine invertebrates and associated fungi.
Topics: Alkaloids; Animals; Biodiversity; Biological Products; Biotechnology; Fungal Proteins; Fungi; Marine Biology; Marine Toxins; Models, Chemical; Oxazoles; Porifera; Staurosporine; Urochordata | 2003 |
Chromosome aberrations induced by high-LET radiations.
Topics: Astronauts; Chromosome Aberrations; Chromosomes; Cosmic Radiation; Enzyme Inhibitors; Fibroblasts; Humans; In Situ Hybridization, Fluorescence; Interphase; Linear Energy Transfer; Lymphocytes; Marine Toxins; Mitosis; Oxazoles; Phosphoprotein Phosphatases; Radiation Dosage; Relative Biological Effectiveness; Space Flight; Weightlessness | 2004 |
Carcinogenic aspects of protein phosphatase 1 and 2A inhibitors.
Topics: Animals; Carcinogens; Disease Progression; Enzyme Inhibitors; Humans; Marine Toxins; Mice; Models, Molecular; Neoplasms; Neoplasms, Experimental; Okadaic Acid; Oxazoles; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Skin Neoplasms; Stomach Neoplasms; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 2009 |
Role of protein phosphatases and mitochondria in the neuroprotective effects of estrogens.
Topics: Animals; Calcineurin; Endoplasmic Reticulum; Enzyme Activation; Estrogens; Gene Expression Regulation; Humans; Marine Toxins; Mitochondria; Nerve Degeneration; Neuroprotective Agents; Oxazoles; Oxidation-Reduction; Oxidative Stress; Phosphoprotein Phosphatases; Signal Transduction | 2009 |
Calyculins and related marine natural products as serine-threonine protein phosphatase PP1 and PP2A inhibitors and total syntheses of calyculin A, B, and C.
Topics: Animals; Enzyme Inhibitors; Humans; Marine Toxins; Organophosphates; Oxazoles; Protein Phosphatase 1; Protein Phosphatase 2; Species Specificity; Stereoisomerism | 2010 |
Cell Death Inducing Microbial Protein Phosphatase Inhibitors--Mechanisms of Action.
Topics: Animals; Apoptosis; Carcinogens; Cell Death; Enzyme Inhibitors; Humans; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Reactive Oxygen Species | 2015 |
Calyculin: Nature's way of making the sponge-derived cytotoxin.
Topics: Animals; Antineoplastic Agents; Cytotoxins; Marine Biology; Marine Toxins; Molecular Structure; Multigene Family; Oxazoles; Peptides; Porifera; Protein Phosphatase 1; Protein Phosphatase 2 | 2016 |
881 other study(ies) available for oxazoles and calyculin a
| Article | Year |
|---|---|
Effects of calyculin A on amylase release in streptolysin-O permeabilized acinar cells.
Topics: Amylases; Animals; Bacterial Proteins; Calcium; Carcinogens; Cell Membrane Permeability; Dose-Response Relationship, Drug; Ethers, Cyclic; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Kinetics; Male; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Rats; Rats, Sprague-Dawley; Streptolysins; Tetradecanoylphorbol Acetate | 1992 |
Effects of antagonists of protein phosphatases on superoxide release by neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Autoradiography; Calcium; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Guinea Pigs; Isoquinolines; Magnesium; Marine Toxins; Models, Biological; Neutrophils; Okadaic Acid; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Piperazines; Superoxides; Tetradecanoylphorbol Acetate | 1992 |
The effects of okadaic acid and calyculin A on thrombin induced platelet reaction.
Topics: Adenosine Triphosphate; Blood Platelets; Calcium; Epoprostenol; Ethers, Cyclic; Humans; In Vitro Techniques; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Platelet Aggregation; Platelet Aggregation Inhibitors; Protein Phosphatase 1; Thrombin | 1992 |
Protein phosphatase inhibitors induce the sustained expression of the Egr-1 gene and the hyperphosphorylation of its gene product.
Topics: 3T3 Cells; Animals; Base Sequence; Blood; Blotting, Northern; Blotting, Western; Cells, Cultured; DNA; DNA-Binding Proteins; Early Growth Response Protein 1; Ethers, Cyclic; Gene Expression Regulation; Humans; Immediate-Early Proteins; Kinetics; Marine Toxins; Mice; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Transcription Factors | 1992 |
Inhibitors of protein phosphatase type 1 and 2A attenuate phosphatidylinositol metabolism and Ca(2+)-transients in human platelets. Role of a cdc2-related protein kinase.
Topics: Blood Platelets; Calcium; CDC2 Protein Kinase; Electrophoresis, Gel, Two-Dimensional; Ethers, Cyclic; Humans; In Vitro Techniques; Marine Toxins; Okadaic Acid; Oxazoles; Peptide Mapping; Phosphatidylinositols; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Secretory Rate; Serotonin; Thrombin | 1992 |
Study of O-glycan sialylation in C6 cultured glioma cells: regulation of a beta-galactoside alpha 2,3 sialyltransferase activity by Ca2+/calmodulin antagonists and phosphatase inhibitors.
Topics: Animals; beta-Galactoside alpha-2,3-Sialyltransferase; Calmodulin; Carbohydrate Sequence; Ethers, Cyclic; Glioma; Glycosylation; Homeostasis; Imidazoles; Kinetics; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Sialyltransferases; Sulfonamides; Tumor Cells, Cultured | 1992 |
Comparative effects of protein phosphatase inhibitors (okadaic acid and calyculin A) on human leukemia HL60, HL60/ADR and K562 cells.
Topics: Cell Death; Cell Division; Ethers, Cyclic; Humans; Leukemia; Marine Toxins; Mitosis; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Tumor Cells, Cultured | 1992 |
Changes in the cytoskeleton of 3T3 fibroblasts induced by the phosphatase inhibitor, calyculin-A.
Topics: 3T3 Cells; Actins; Animals; Cell Fractionation; Cell Nucleus; Cytoskeletal Proteins; Cytoskeleton; Intermediate Filament Proteins; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Processing, Post-Translational; Vimentin | 1992 |
Calyculin A modulates voltage-dependent outward current in guinea-pig taenia coli smooth muscle cells.
Topics: Animals; Calcium; Colon; Guinea Pigs; In Vitro Techniques; Ion Channel Gating; Marine Toxins; Membrane Potentials; Muscle, Smooth; Oxazoles; Phosphoprotein Phosphatases; Potassium Channels; Protein Kinases | 1992 |
Calcium and potassium channel regulation by protein phosphorylation in smooth muscle cells of guinea pig taenia coli.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Atropine; Calcium Channels; Carbachol; Colon; Guinea Pigs; In Vitro Techniques; Isoquinolines; Marine Toxins; Membrane Potentials; Models, Biological; Muscle, Smooth; Nifedipine; Oxazoles; Phorbol 12,13-Dibutyrate; Phorbol Esters; Phosphorylation; Piperazines; Potassium Channels; Protein Kinase C | 1992 |
Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on insulin release from rat pancreatic islets.
Topics: Animals; Colforsin; Dose-Response Relationship, Drug; Ethers, Cyclic; Glucose; Insulin; Insulin Secretion; Islets of Langerhans; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Potassium; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate | 1992 |
Effects of the protein phosphatase inhibitors okadaic acid and calyculin A on metabolically inhibited and ischaemic isolated myocytes.
Topics: Adenosine Triphosphate; Animals; Cell Survival; Ethers, Cyclic; Heart; In Vitro Techniques; Marine Toxins; Myocardial Contraction; Myocardial Ischemia; Myocardium; Okadaic Acid; Osmotic Fragility; Oxazoles; Phosphoprotein Phosphatases; Rats | 1992 |
Cytoskeletal integrity in interphase cells requires protein phosphatase activity.
Topics: Animals; Cell Line; Cricetinae; Cytoskeleton; Ethers, Cyclic; Interphase; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Peptide Mapping; Phosphopeptides; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinases; Pyrans; Vimentin | 1992 |
Protein phosphatase inhibitors okadaic acid and calyculin A alter cell shape and F-actin distribution and inhibit stimulus-dependent increases in cytoskeletal actin of human neutrophils.
Topics: Actins; Cytoskeleton; Dimethyl Sulfoxide; Dose-Response Relationship, Drug; Edetic Acid; Ethers, Cyclic; Humans; In Vitro Techniques; Kinetics; Marine Toxins; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Pinocytosis; Tetradecanoylphorbol Acetate | 1992 |
Augmentation of retinoic acid-induced granulocytic differentiation in HL-60 leukemia cells by serine/threonine protein phosphatase inhibitors.
Topics: Cell Adhesion; Cell Differentiation; Chromatography, Agarose; Ethers, Cyclic; Granulocytes; Humans; Leukemia; Macrophages; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Tetradecanoylphorbol Acetate; Tretinoin; Tumor Cells, Cultured | 1992 |
Differentiation induction in human breast tumor cells by okadaic acid and related inhibitors of protein phosphatases 1 and 2A.
Topics: Antibodies, Monoclonal; Autoradiography; Blotting, Northern; Breast Neoplasms; Caseins; Cell Differentiation; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Female; Fluorescent Antibody Technique; Gene Expression; Genes, fos; Genes, jun; Humans; Isoenzymes; Kinetics; Marine Toxins; Microcystins; Okadaic Acid; Oligonucleotide Probes; Oxazoles; Peptides, Cyclic; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Pyrans; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1992 |
Protein phosphatase inhibitors and bone resorption: inhibition by okadaic acid and biphasic actions of calyculin-A.
Topics: Animals; Animals, Newborn; Autoradiography; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Cyclic AMP; Dinoprostone; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Kinetics; Marine Toxins; Mice; Mice, Inbred Strains; Okadaic Acid; Organ Culture Techniques; Oxazoles; Parathyroid Hormone; Peptide Fragments; Phosphates; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorus Radioisotopes; Protein Biosynthesis; Protein Phosphatase 1; RNA; Teriparatide; Tetradecanoylphorbol Acetate | 1992 |
Okadaic acid and calyculin A enhance the effect of thyrotropin-releasing hormone on GH3 rat anterior pituitary cells excitability.
Topics: Action Potentials; Animals; Cells, Cultured; Ethers, Cyclic; Ionophores; Marine Toxins; Microelectrodes; Okadaic Acid; Oscillometry; Oxazoles; Pituitary Gland, Anterior; Rats; Thyrotropin-Releasing Hormone | 1992 |
Calyculin A induces contractile ring-like apparatus formation and condensation of chromosomes in unfertilized sea urchin eggs.
Topics: Actin Cytoskeleton; Actins; Animals; Carcinogens; Cell Division; Chromosomes; Female; Fertilization; Histones; Marine Toxins; Muscles; Myosins; Ovum; Oxazoles; Phosphorylation; Rabbits; Sea Urchins; Species Specificity | 1992 |
Nonphorbol tumor promoters okadaic acid and calyculin-A induce membrane translocation of protein kinase C.
Topics: Animals; Carcinogens; Cell Line; Cell Membrane; Cytosol; Ethers, Cyclic; Immunoblotting; Kidney; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Protein Kinase C; Rats; Tetradecanoylphorbol Acetate | 1992 |
A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle.
Topics: Animals; Antifungal Agents; Aorta; Calcium; Enzyme Inhibitors; Ethers, Cyclic; Guinea Pigs; Kinetics; Macromolecular Substances; Marine Toxins; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Myosins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pyrans; Rabbits; Rats; Spiro Compounds; Verapamil | 1991 |
Inhibition of electrical slow waves and Ca2+ currents of gastric and colonic smooth muscle by phosphatase inhibitors.
Topics: Animals; Calcium Channels; Colon; Dogs; Electrophysiology; Ethers, Cyclic; Female; Gastric Mucosa; In Vitro Techniques; Male; Marine Toxins; Muscle, Smooth; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Stomach | 1991 |
Regulation of Ca(2+)-activated K+ channels by protein kinase A and phosphatase inhibitors.
Topics: Animals; Calcium; Dogs; Ethers, Cyclic; Female; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Potassium Channels; Protein Kinases | 1991 |
Calyculin A increases voltage-dependent inward current in smooth muscle cells isolated from guinea pig taenia coli.
Topics: Animals; Barium; Calcium Channels; Cell Separation; Colon; Guinea Pigs; Marine Toxins; Membrane Potentials; Muscle, Smooth; Oxazoles; Protein Kinase C | 1991 |
Mechanisms of action of okadaic acid class tumor promoters on mouse skin.
Topics: Animals; Carcinogens; DNA; DNA Damage; DNA, Neoplasm; Enzyme Activation; Ethers, Cyclic; Genes, ras; Humans; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; Proteins; Pyrans; Receptors, Drug; Skin; Skin Neoplasms; Structure-Activity Relationship | 1991 |
Okadaic acid inhibits angiotensin II stimulation of Ins(1,4,5)P3 and calcium signalling in rat hepatocytes.
Topics: Angiotensin II; Animals; Calcium; Ethers, Cyclic; Inositol 1,4,5-Trisphosphate; Ionophores; Liver; Marine Toxins; Okadaic Acid; Oxazoles; Rats; Signal Transduction | 1992 |
Contraction of rat thoracic aorta strips by endothelin-1 in the absence of extracellular Ca2+.
Topics: Animals; Aorta, Thoracic; Caffeine; Calcium; Endothelins; In Vitro Techniques; Indicators and Reagents; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth, Vascular; Norepinephrine; Oxazoles; Phorbol 12,13-Dibutyrate; Rats; Rats, Inbred Strains; Tetradecanoylphorbol Acetate; Urotensins; Vasoconstrictor Agents | 1991 |
Calyculin-A increases the level of protein phosphorylation and changes the shape of 3T3 fibroblasts.
Topics: Animals; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Endopeptidases; Fibroblasts; Intermediate Filaments; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests | 1991 |
Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Binding Sites; Ethers, Cyclic; Female; Marine Toxins; Mice; Mice, Inbred Strains; Molecular Weight; Nuclear Proteins; Nucleolin; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; RNA-Binding Proteins; Skin; Skin Neoplasms | 1990 |
A new pathway of tumor promotion by the okadaic acid class compounds.
Topics: Animals; Binding, Competitive; Brain; Carcinogens; Cytosol; DNA, Neoplasm; Ethers, Cyclic; Humans; Marine Toxins; Mice; Molecular Structure; Mutation; Nuclear Proteins; Nucleolin; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Protein Kinases; Proteins; Proto-Oncogene Proteins p21(ras); Pyrans; Receptors, Drug; RNA-Binding Proteins; Skin; Skin Neoplasms; Spiro Compounds; Structure-Activity Relationship | 1990 |
Modification by calyculin A of inward Ca currents in smooth muscle cells isolated from guinea pig taenia coli.
Topics: Animals; Benzofurans; Calcium; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Guinea Pigs; In Vitro Techniques; Intestine, Large; Marine Toxins; Muscle Contraction; Muscle, Smooth; Oxazoles | 1990 |
Calyculins, potent antitumour metabolites from the marine sponge Discodermia calyx: biological activities.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Fluorescent Antibody Technique; Marine Toxins; Neoplasms, Experimental; Ovum; Oxazoles; Porifera; Sea Urchins; Staining and Labeling; Starfish | 1988 |
Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.
Topics: Alkaline Phosphatase; Animals; Cattle; Chickens; Ethers, Cyclic; Female; Humans; Kinetics; Macromolecular Substances; Marine Toxins; Myosins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Placenta; Pregnancy; Vasoconstrictor Agents | 1989 |
Calcium-independent activation of contractile apparatus in smooth muscle by calyculin-A.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Actomyosin; Animals; Aorta, Thoracic; Ca(2+) Mg(2+)-ATPase; Calcium; Calcium-Transporting ATPases; Cecum; Egtazic Acid; Guinea Pigs; In Vitro Techniques; Kinetics; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Oxazoles; Phosphorylation; Porifera; Rats; Rats, Inbred Strains; Verapamil | 1989 |
[Action of cytochalasin B on the contraction of smooth muscle of guinea pig taenia coli].
Topics: Animals; Calcium Channels; Colon; Cytochalasin B; Guinea Pigs; In Vitro Techniques; Marine Toxins; Muscle Contraction; Muscle, Smooth; Oxazoles; Potassium | 1989 |
[Effect of calyculin A on the contraction of colonic smooth muscle of guinea pigs].
Topics: Animals; Calcium; Calcium Channels; Colon; Guinea Pigs; In Vitro Techniques; Marine Toxins; Muscle Contraction; Muscle, Smooth; Oxazoles | 1989 |
H2O2 activates red blood cell K-Cl cotransport via stimulation of a phosphatase.
Topics: Alkaloids; Animals; Carrier Proteins; Catalase; Erythrocytes; Ethylmaleimide; Hydrogen Peroxide; Intracellular Membranes; K Cl- Cotransporters; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Potassium; Sheep; Staurosporine; Symporters | 1995 |
Regulation of human natural killer-cell lytic activity by serine/threonine phosphatases and kinases.
Topics: Cell Line; Cytotoxicity, Immunologic; Enzyme Inhibitors; Ethers, Cyclic; Homeostasis; Humans; Killer Cells, Natural; Kinetics; Lymphoma; Marine Toxins; Okadaic Acid; Oxazoles; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatases; Thymus Neoplasms; Tumor Cells, Cultured | 1995 |
Down-regulation of c-Myc and Max genes is associated to inhibition of protein phosphatase 2A in K562 human leukemia cells.
Topics: Apoptosis; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Basic-Leucine Zipper Transcription Factors; Blotting, Northern; Cell Line; DNA-Binding Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers, Cyclic; Gene Expression Regulation, Neoplastic; Genes, myc; Humans; Kinetics; Leukemia, Erythroblastic, Acute; Marine Toxins; Okadaic Acid; Oxazoles; Protein Biosynthesis; Protein Phosphatase 2; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-myc; RNA, Messenger; Time Factors; Transcription Factors; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
Hyperphosphorylated p47-phox lost the ability to activate NADPH oxidase in guinea pig neutrophils.
Topics: Animals; Cell Membrane; Cytosol; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Kinetics; Marine Toxins; NADH, NADPH Oxidoreductases; NADPH Dehydrogenase; NADPH Oxidases; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Neuronal differentiation of Neuro 2a cells by lactacystin and its partial inhibition by the protein phosphatase inhibitors calyculin A and okadaic acid.
Topics: Acetylcholinesterase; Acetylcysteine; Animals; Antifungal Agents; Biomarkers; Bucladesine; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Ethers, Cyclic; Hydroquinones; Kinetics; Marine Toxins; Neurites; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Pyrans; Spiro Compounds; Time Factors | 1995 |
Stimulation of motility and respiration of intact fowl spermatozoa by calyculin A, a specific inhibitor of protein phosphatase-1 and -2A, via a Ca2+-dependent mechanism.
Topics: Animals; Calcium; Calcium Chloride; Cells, Cultured; Chickens; Dose-Response Relationship, Drug; Egtazic Acid; Intracellular Fluid; Male; Marine Toxins; Oxazoles; Oxygen Consumption; Phosphoprotein Phosphatases; Protein Phosphatase 1; Sperm Motility; Spermatozoa | 1995 |
T cell apoptosis induced by interleukin-2 deprivation or transforming growth factor-beta 2: modulation by the phosphatase inhibitors okadaic acid and calyculin A.
Topics: Animals; Apoptosis; Cell Division; Cell Line; Cell Membrane; DNA Damage; Endoplasmic Reticulum, Rough; Enzyme Inhibitors; Ethers, Cyclic; Gene Expression Regulation; Interleukin-2; Marine Toxins; Mice; Nucleosomes; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; RNA, Messenger; T-Lymphocytes; Transforming Growth Factor beta | 1995 |
Stimulation of protein kinase C activity by compactin in vascular smooth muscle cells.
Topics: Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Hypolipidemic Agents; Lovastatin; Marine Toxins; Mevalonic Acid; Muscle, Smooth, Vascular; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Rats | 1995 |
Enhancement of AMPA-mediated synaptic transmission by the protein phosphatase inhibitor calyculin A in rat hippocampal slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Hippocampus; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Magnesium; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Piperazines; Quinoxalines; Rats; Rats, Inbred Strains; Receptors, AMPA; Synaptic Transmission | 1993 |
Role of phosphorylation in keratin and vimentin filament integrity in cultured thyroid epithelial cells.
Topics: Animals; Blotting, Western; Cells, Cultured; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Cytoplasm; Cytoskeleton; Dogs; Intermediate Filaments; Keratins; Marine Toxins; Microscopy, Fluorescence; Oxazoles; Peptide Mapping; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thyroid Gland; Thyrotropin; Vimentin | 1993 |
Serine/threonine phosphatases play a role in stimulus-secretion coupling in pancreatic acinar cells.
Topics: Amylases; Animals; Culture Techniques; Cyclosporine; Dose-Response Relationship, Drug; Ethers, Cyclic; Male; Marine Toxins; Microscopy, Electron; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Secretory Rate; Signal Transduction; Threonine | 1994 |
Inhibition of phosphoprotein phosphatases blocks metabotropic glutamate receptor effects in the rat nucleus tractus solitarii.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cycloleucine; Ethers, Cyclic; In Vitro Techniques; Marine Toxins; Membrane Potentials; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Receptors, Metabotropic Glutamate; Solitary Nucleus; Tacrolimus | 1994 |
Calyculin A, okadaic acid and W-7 interfere with a distal step in pancreatic acinar signal transduction.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amylases; Animals; Calcium; Cyclic AMP; Ethers, Cyclic; Inositol 1,4,5-Trisphosphate; Male; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Rats; Rats, Wistar; Secretory Rate; Signal Transduction; Sulfonamides; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin; Vasoactive Intestinal Peptide | 1994 |
Regulation of riboflavin intestinal uptake by protein kinase A: studies with Caco-2 cells.
Topics: 1-Methyl-3-isobutylxanthine; Carrier Proteins; Cell Line; Colchicine; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cycloheximide; Dactinomycin; Humans; Intestinal Mucosa; Marine Toxins; Oxazoles; Protein Kinase C; Riboflavin; Tetradecanoylphorbol Acetate | 1994 |
Protein kinases and phosphatases modulate c-fos expression in rat hepatocytes. Effects of angiotensin II and phorbol myristate acetate.
Topics: Alkaloids; Angiotensin II; Animals; Ethers, Cyclic; Female; Gene Expression; Genes, fos; Genistein; Isoflavones; Marine Toxins; Microcystins; Naphthalenes; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Polycyclic Compounds; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Tetradecanoylphorbol Acetate | 1995 |
The MEK kinase activity of the catalytic domain of RAF-1 is regulated independently of Ras binding in T cells.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibodies, Monoclonal; Binding Sites; Cell Line; Enzyme Activation; Epitopes; Ethers, Cyclic; Hemagglutinins; Humans; MAP Kinase Kinase Kinase 1; Marine Toxins; Mice; Molecular Sequence Data; Okadaic Acid; Oligopeptides; Oxazoles; Phosphoprotein Phosphatases; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; ras Proteins; Receptor-CD3 Complex, Antigen, T-Cell; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Phosphatase inhibitors potentiate adrenergic-stimulated cAMP and cGMP production in rat pinealocytes.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Antifungal Agents; Cyclic AMP; Cyclic GMP; Drug Synergism; Ethers, Cyclic; Isoproterenol; Kinetics; Male; Marine Toxins; Norepinephrine; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pineal Gland; Protein Phosphatase 2; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds | 1995 |
Differential inhibitory effects of serine/threonine phosphatase inhibitors and a calmodulin antagonist on phosphoinositol/calcium- and cyclic adenosine monophosphate-mediated pancreatic amylase secretion.
Topics: Amylases; Animals; Calcium; Calmodulin; Cyclic AMP; Cyclosporine; Ethers, Cyclic; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Male; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Rats, Wistar; Signal Transduction; Sulfonamides | 1995 |
Pacemaker current i(f) in adult canine cardiac ventricular myocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Clocks; Dogs; Electrophysiology; Female; Heart Ventricles; In Vitro Techniques; Ion Channels; Isoquinolines; Kinetics; Male; Marine Toxins; Myocardium; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Piperazines; Potassium; Protein Kinase C; Purkinje Cells; Sodium | 1995 |
Inhibition of serine/threonine protein phosphatases enhances agonist-stimulated cAMP accumulation in UMR 106 osteoblast-like cells.
Topics: 1-Methyl-3-isobutylxanthine; Antifungal Agents; Colforsin; Cyclic AMP; Dinoprostone; Ethers, Cyclic; Humans; Kinetics; Marine Toxins; Okadaic Acid; Osteoblasts; Oxazoles; Parathyroid Hormone; Parathyroid Hormone-Related Protein; Protein Serine-Threonine Kinases; Proteins; Pyrans; Spiro Compounds; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Transient and persistent phosphorylation of AMPA-type glutamate receptor subunits in cerebellar Purkinje cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acid Sequence; Animals; Binding Sites; Cyclic GMP; Dendrites; Drug Tolerance; Long-Term Potentiation; Male; Marine Toxins; Molecular Sequence Data; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Purkinje Cells; Rats; Rats, Wistar; Receptors, AMPA; Synapses | 1995 |
Induction of a retinoblastoma phosphatase activity by anticancer drugs accompanies p53-independent G1 arrest and apoptosis.
Topics: Antineoplastic Agents; Apoptosis; Cell Cycle; Cell Line; Cyclin-Dependent Kinases; Cytarabine; DNA Damage; DNA, Neoplasm; Enzyme Induction; Enzyme Inhibitors; G1 Phase; Humans; Leukemia, Monocytic, Acute; Leukemia, Promyelocytic, Acute; Marine Toxins; Oxazoles; Protein Tyrosine Phosphatases; Retinoblastoma Protein; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Zinc | 1995 |
Microcystin uptake and inhibition of protein phosphatases: effects of chemoprotectants and self-inhibition in relation to known hepatic transporters.
Topics: Animals; Biological Transport; Cyclosporine; Enzyme Inhibitors; Liver; Male; Marine Toxins; Mice; Microcystins; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Taurocholic Acid | 1995 |
Inhibition of asialoglycoprotein endocytosis and degradation in rat hepatocytes by protein phosphatase inhibitors.
Topics: Animals; Asialoglycoproteins; Cell Fractionation; Cellobiose; Centrifugation, Density Gradient; Endocytosis; Enzyme Inhibitors; Ethers, Cyclic; Genistein; Iodine Radioisotopes; Isoflavones; Liver; Male; Marine Toxins; Microcystins; Okadaic Acid; Orosomucoid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Rats; Rats, Wistar; Tyramine; Vacuoles | 1995 |
The protein phosphatase inhibitor calyculin A stimulates chemokine production by human synovial cells.
Topics: Cells, Cultured; Chemokine CCL2; Chemokine CCL5; Cytokines; Enzyme Inhibitors; Ethers, Cyclic; Fibroblasts; Gene Expression; Humans; Interleukin-1; Interleukin-6; Interleukin-8; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; RNA, Messenger; Synovial Membrane; Tumor Necrosis Factor-alpha | 1995 |
8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adenocarcinoma; Adenosine Deaminase; Amino Acid Sequence; Apoptosis; Biotransformation; Breast Neoplasms; Chromatin; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; DNA Damage; Ethers, Cyclic; Female; Humans; Marine Toxins; Microvilli; Molecular Sequence Data; Necrosis; Okadaic Acid; Organelles; Oxazoles; Phosphoprotein Phosphatases | 1995 |
Failure to dephosphorylate retinoblastoma protein in drug-resistant cells.
Topics: Antineoplastic Agents; Apoptosis; Chlorides; Cytarabine; Drug Resistance; Etoposide; G1 Phase; HL-60 Cells; Humans; Marine Toxins; Oxazoles; Phosphorylation; Retinoblastoma Protein; Zinc Compounds | 1995 |
A Mg(2+)-dependent, Ca(2+)-inhibitable serine/threonine protein phosphatase from bovine brain.
Topics: Amino Acid Sequence; Animals; Brain; Calcium; Cations; Cattle; Enzyme Inhibitors; Ethers, Cyclic; Magnesium; Marine Toxins; Mice; Molecular Sequence Data; Molecular Weight; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylase a; Phosphorylase Kinase; Protein Conformation; Protein Phosphatase 2; Protein Phosphatase 2C; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 1995 |
Isotype-specific activation of cystic fibrosis transmembrane conductance regulator-chloride channels by cGMP-dependent protein kinase II.
Topics: Adenosine Triphosphate; Animals; Cattle; Cell Line; Cell Membrane; Chloride Channels; Cyclic GMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Intestines; Isoenzymes; Kinetics; Lung; Macromolecular Substances; Marine Toxins; Membrane Potentials; Microvilli; Oxazoles; Peptide Fragments; Phosphopeptides; Phosphorylation; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Rats; Recombinant Proteins; Swine; Transfection | 1995 |
The effects of calyculin A upon calcium-, guanine nucleotides- and phorbol 12-myristate 13-acetate-stimulated ACTH secretion from AtT-20 cells.
Topics: Adrenocorticotropic Hormone; Animals; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Guanine Nucleotides; Guanosine Triphosphate; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Pituitary Neoplasms; Radioimmunoassay; Tetradecanoylphorbol Acetate | 1995 |
Activation of an Na+/K+/2Cl- cotransport system by phosphorylation in crypt cells isolated from guinea pig distal colon.
Topics: Animals; Bumetanide; Calcium; Chlorides; Colon; Ethers, Cyclic; Guinea Pigs; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Ionomycin; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Protein Kinases; Sodium | 1995 |
Stimulation of protein phosphatases as a mechanism of the muscarinic-receptor-mediated inhibition of cardiac L-type Ca2+ channels.
Topics: Acetylcholine; Animals; Calcium Channels; Chick Embryo; Dose-Response Relationship, Drug; Ethers, Cyclic; Female; Isoproterenol; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Receptors, Muscarinic; Time Factors | 1995 |
Aggregation-dependent signaling in human platelets is sensitive to protein serine/threonine phosphatase inhibitors.
Topics: Blood Platelets; Cytoskeletal Proteins; Ethers, Cyclic; Humans; Kinetics; Marine Toxins; Membrane Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet Aggregation; Platelet Membrane Glycoproteins; Signal Transduction; Thrombin | 1995 |
Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.
Topics: Cysteine Endopeptidases; DNA-Binding Proteins; HeLa Cells; Humans; I-kappa B Proteins; Kinetics; Leupeptins; Marine Toxins; Multienzyme Complexes; Mutagenesis, Site-Directed; NF-kappa B; NF-KappaB Inhibitor alpha; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Proteasome Endopeptidase Complex; Protein Biosynthesis; Recombinant Proteins; Ubiquitins | 1995 |
Activation of NF-kappa B by phosphatase inhibitors involves the phosphorylation of I kappa B alpha at phosphatase 2A-sensitive sites.
Topics: Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Drug Synergism; Enzyme Inhibitors; Ethers, Cyclic; Humans; I-kappa B Proteins; Leupeptins; Marine Toxins; Multienzyme Complexes; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Phosphatase 2; Protein Processing, Post-Translational; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1995 |
Regulation of endothelial cell gap formation and barrier function by myosin-associated phosphatase activities.
Topics: Animals; Blotting, Western; Capillary Permeability; Cattle; Cells, Cultured; Endothelium, Vascular; Ethers, Cyclic; Gap Junctions; Marine Toxins; Myosins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Rabbits; Tissue Distribution | 1995 |
Effects of protein kinase inhibitors and protein phosphatase inhibitors on cyclic AMP-dependent down-regulation of vesicular monoamine transport in pheochromocytoma PC12 cells.
Topics: Animals; Biogenic Monoamines; Biological Transport; Bucladesine; Carbazoles; Cyclic AMP; Down-Regulation; Ethers, Cyclic; Glycoproteins; Indole Alkaloids; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Neuropeptides; Norepinephrine; Okadaic Acid; Oxazoles; PC12 Cells; Pheochromocytoma; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Rats; Serotonin; Vesicular Biogenic Amine Transport Proteins | 1995 |
The serine/threonine phosphatase inhibitor, calyculin A, inhibits and dissociates macrophage responses to lipopolysaccharide.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cytokines; Female; Gene Expression Regulation; Genes, Immediate-Early; Lipopolysaccharides; Macrophages, Peritoneal; Marine Toxins; Mice; Mice, Inbred C3H; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Processing, Post-Translational; Signal Transduction | 1995 |
Dephosphorylation of ezrin as an early event in renal microvillar breakdown and anoxic injury.
Topics: Animals; Cytoskeletal Proteins; Cytoskeleton; Female; Hypoxia; In Vitro Techniques; Kidney Tubules, Proximal; Marine Toxins; Microvilli; Octoxynol; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rabbits; Solubility | 1995 |
Regulation of stimulus-dependent hippocampal acetylcholine release by okadaic acid-sensitive phosphoprotein phosphatases.
Topics: Acetylcholine; Animals; Ethers, Cyclic; Hippocampus; Male; Marine Toxins; Models, Biological; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Synaptosomes; Vanadates | 1995 |
Involvement of protein phosphatases in gonadotropin releasing hormone regulated gonadotropin secretion.
Topics: Animals; Cells, Cultured; Enzyme Activation; Ethers, Cyclic; Female; Gonadotropin-Releasing Hormone; Ionomycin; Luteinizing Hormone; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Gland; Protein Kinase C; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate | 1995 |
Evidence for a dithiol-activated signaling pathway in natural killer cell avidity regulation of leukocyte function antigen-1: structural requirements and relationship to phorbol ester- and CD16-triggered pathways.
Topics: Actins; Animals; Cations, Divalent; Cell Adhesion; Cytoskeleton; Dithiothreitol; Ethers, Cyclic; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Killer Cells, Natural; Lymphocyte Function-Associated Antigen-1; Marine Toxins; Membrane Proteins; Mice; Naphthalenes; Neoplasm Proteins; Okadaic Acid; Oxazoles; Oxidation-Reduction; Phosphoprotein Phosphatases; Phosphorylation; Protein Conformation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Receptors, IgG; Signal Transduction; Structure-Activity Relationship; Sulfhydryl Reagents; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
Protein phosphatase inhibitors, okadaic acid and calyculin A, induce alkaline phosphatase activity in osteoblastic cells derived from newborn mouse calvaria.
Topics: Alkaline Phosphatase; Amino Acids; Animals; Animals, Newborn; Clone Cells; Enzyme Induction; Enzyme Stability; Ethers, Cyclic; Marine Toxins; Mice; Okadaic Acid; Osteoblasts; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Phosphorylation; Skull; Temperature | 1995 |
Protein phosphatase 2A, a potential regulator of actin dynamics and actin-based organelle motility in the green alga Acetabularia.
Topics: Acetabularia; Actins; Amino Acid Sequence; Chloroplasts; Cloning, Molecular; Cytoskeleton; DNA, Complementary; Ethers, Cyclic; Gene Expression Regulation, Developmental; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; RNA, Messenger; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 1995 |
Protein phosphatase inhibitor calyculin A induces hyperphosphorylation of cytokeratins and inhibits amylase exocytosis in the rat parotid acini.
Topics: Amylases; Animals; Blotting, Western; Cyclic AMP; Exocytosis; Keratins; Marine Toxins; Oxazoles; Parotid Gland; Phosphoprotein Phosphatases; Phosphorylation; Rats | 1993 |
The endogenous inhibitor of protein kinase-C in the rat ovary is a protein phosphatase.
Topics: Animals; Brain; Cytosol; Ethers, Cyclic; Female; Histones; Marine Toxins; Microcystins; Myelin Basic Protein; Okadaic Acid; Ovary; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase C; Pseudopregnancy; Rats; Rats, Sprague-Dawley | 1993 |
Gene amplification and multidrug resistance induced by the phosphatase-inhibitory tumor promoter, okadaic acid.
Topics: 3T3 Cells; Animals; Carcinogens; Cell Division; Doxorubicin; Drug Resistance, Multiple; Drug Synergism; Ethers, Cyclic; Gene Amplification; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Verapamil | 1995 |
Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line.
Topics: Animals; Apoptosis; Cell Cycle; Cell Membrane; Cell Nucleus; Chromatin; Cyclic AMP; Cytoplasm; DNA Damage; Dose-Response Relationship, Drug; Ethers, Cyclic; Leukemia, Promyelocytic, Acute; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; RNA, Ribosomal, 28S; Signal Transduction; Tumor Cells, Cultured | 1994 |
Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A.
Topics: Animals; Cells, Cultured; Endothelium, Vascular; Liver; Male; Marine Toxins; Microcystins; Oxazoles; Peptides, Cyclic; Perfusion; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley | 1995 |
Contrasting effects of calyculin A and okadaic acid on the respiratory burst of human neutrophils.
Topics: Amino Acid Sequence; Calcimycin; Ethers, Cyclic; Humans; In Vitro Techniques; Marine Toxins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Respiratory Burst; Superoxides; Tetradecanoylphorbol Acetate | 1995 |
Platelet talin is phosphorylated by calyculin A.
Topics: Alkalies; Antibodies, Monoclonal; Blood Platelets; Electrophoresis, Polyacrylamide Gel; Humans; Isotope Labeling; Marine Toxins; Oxazoles; Peptides; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Precipitin Tests; Serine; Talin; Threonine; Tyrosine | 1995 |
Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.
Topics: beta-Adrenergic Receptor Kinases; Cyclic AMP-Dependent Protein Kinases; Humans; Marine Toxins; Monensin; Oxazoles; Phosphorylation; Receptors, Adrenergic, beta-2; Sucrose; Tumor Cells, Cultured | 1995 |
Cytoskeletal reorganization of human platelets induced by the protein phosphatase 1/2 A inhibitors okadaic acid and calyculin A.
Topics: Actins; Adult; Antibodies; Blood Platelets; Cytoskeleton; Ethers, Cyclic; Humans; Marine Toxins; Microscopy, Confocal; Microscopy, Electron; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Phosphatase 1; Tubulin | 1995 |
Protein-tyrosine phosphatase inhibitors block tumor necrosis factor-dependent activation of the nuclear transcription factor NF-kappa B.
Topics: Adenosine Triphosphate; Arsenicals; Base Sequence; Ceramides; Diamide; DNA-Binding Proteins; Dose-Response Relationship, Drug; Ethers, Cyclic; Humans; I-kappa B Proteins; In Vitro Techniques; Interleukin-1; Marine Toxins; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Oligodeoxyribonucleotides; Oxazoles; Protein Tyrosine Phosphatases; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Vanadates | 1995 |
Calyculin-A-induced fast neurite retraction in nerve growth factor-differentiated rat pheochromocytoma (PC12) cells.
Topics: Animals; Calcium; Cell Differentiation; Cytoskeleton; Ethers, Cyclic; Fura-2; Marine Toxins; Nerve Growth Factors; Neurites; Okadaic Acid; Oxazoles; PC12 Cells; Phosphoprotein Phosphatases; Rats | 1995 |
Inhibition of protein kinase C results in a switch from a non-motile to a motile phenotype in diverse human lymphocyte populations.
Topics: Alkaloids; B-Lymphocytes; Blotting, Western; Cell Line; Cell Movement; Cells, Cultured; Enzyme Activation; Humans; Indoles; Lymphocytes; Maleimides; Marine Toxins; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Protein Kinase C; Staurosporine; T-Lymphocytes | 1995 |
A unique role of protein phosphatases in cerebellar long-term depression.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Evoked Potentials; Guinea Pigs; In Vitro Techniques; Marine Toxins; Microcystins; Neuronal Plasticity; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Purkinje Cells | 1995 |
Arachidonic acid-dependent phosphorylation of troponin I and myosin light chain 2 in cardiac myocytes.
Topics: Actin Cytoskeleton; Animals; Arachidonic Acid; Blotting, Western; Calcium; Endothelins; Enzyme Activation; Heart Ventricles; In Vitro Techniques; Marine Toxins; Myocardial Contraction; Myocardium; Myofibrils; Myosins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rabbits; Rats; Tetradecanoylphorbol Acetate; Troponin; Troponin I | 1995 |
Phosphoprotein phosphatase activities in rat luteal cells.
Topics: Animals; Cantharidin; Corpus Luteum; Ethers, Cyclic; Female; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Superovulation | 1995 |
Phosphatase is responsible for run down, and probably G protein-mediated inhibition of inwardly rectifying K+ currents in guinea pig chromaffin cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Alkaline Phosphatase; Aluminum Compounds; Animals; Chromaffin System; Down-Regulation; Electrophysiology; Female; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Guinea Pigs; Isoquinolines; Marine Toxins; Membrane Potentials; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Potassium Channel Blockers; Potassium Channels; Protein Phosphatase 1; Sulfonamides | 1995 |
K+ channels in the basolateral membrane of rat cortical collecting duct are regulated by a cGMP-dependent protein kinase.
Topics: Adenosine Triphosphate; Alkaloids; Animals; Biotransformation; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Female; In Vitro Techniques; Indoles; Kidney Tubules, Collecting; Marine Toxins; Membranes; Nitroprusside; Nystatin; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Potassium Channels; Rats; Rats, Wistar | 1995 |
Stimulation of KCl co-transport in equine erythrocytes by hydrostatic pressure: effects of kinase/phosphatase inhibition.
Topics: Animals; Biological Transport, Active; Cell Size; Erythrocytes; Ethylmaleimide; Horses; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Potassium Chloride; Pressure; Protein Kinase Inhibitors; Rubidium Radioisotopes | 1995 |
Sensitization by calyculin A of brain capillary endothelial cells to endothelin-1.
Topics: Animals; Brain; Calcium; Capillaries; Carrier Proteins; Cells, Cultured; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Marine Toxins; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Receptors, Endothelin; Rubidium Radioisotopes; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Vasoconstrictor Agents | 1995 |
Effects of the phosphatase inhibitor calyculin A on the phosphorylation of C-protein in mammalian ventricular cardiomyocytes.
Topics: Animals; Carrier Proteins; Cells, Cultured; Guinea Pigs; Heart; Heart Ventricles; Marine Toxins; Myocardium; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation | 1995 |
Rapid dephosphorylation of tau in heat-shocked fetal rat cerebral explants: prevention and hyperphosphorylation by inhibitors of protein phosphatases PP1 and PP2A.
Topics: Animals; Axons; Brain; Ethers, Cyclic; Female; Hot Temperature; Immunohistochemistry; In Vitro Techniques; Male; Marine Toxins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Shock; tau Proteins | 1995 |
Serine/threonine kinase activation in human neutrophils: relationship to tyrosine phosphorylation.
Topics: Enzyme Activation; Humans; Marine Toxins; Molecular Weight; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Tyrosine | 1994 |
Calyculin A, a non-phorbol ester type tumor promotor, induced oxidative DNA damage in stimulated human neutrophil-like cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Carcinogens; Catalase; Cell Line; Cell Survival; Deoxyguanosine; Dimethyl Sulfoxide; DNA Damage; Glutathione Peroxidase; Humans; Kinetics; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Reactive Oxygen Species; Superoxides | 1994 |
Okadaic acid indicates a major function for protein phosphatases in stimulus-response coupling of RINm5F rat insulinoma cells.
Topics: Animals; Bucladesine; Carbachol; Colforsin; Cyclic AMP; Ethers, Cyclic; Insulin; Insulinoma; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Tumor Cells, Cultured | 1994 |
Appearance of rereplication and activation of DNA replication by calyculin A in a cell-free extract of activated Xenopus eggs.
Topics: Animals; Cell Extracts; Cell Nucleus; DNA Replication; Egg Proteins; Male; Marine Toxins; Ovum; Oxazoles; Phosphoprotein Phosphatases; S Phase; Spermatozoa; Xenopus | 1995 |
Calyculin A blocks bovine chromaffin cell calcium channels independently of phosphatase inhibition.
Topics: Adrenal Medulla; Animals; Calcium Channel Blockers; Calcium Channels; Carbazoles; Cattle; Cells, Cultured; Indole Alkaloids; Marine Toxins; Membrane Potentials; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C | 1994 |
Evidence for protein phosphatase 1 and 2A regulation of K+ channels in two types of leaf cells.
Topics: Adenosine Triphosphate; Egtazic Acid; Ethers, Cyclic; Fabaceae; Homeostasis; Kinetics; Marine Toxins; Membrane Potentials; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Plant Leaves; Plants, Medicinal; Potassium Channels; Protein Phosphatase 1 | 1994 |
Potassium and calcium channel involvement in induction of long-lasting synaptic enhancement by calyculin A, a protein phosphatase inhibitor, in rat hippocampal CA1 region.
Topics: Animals; Calcium Channels; Evoked Potentials; Glutamic Acid; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Potassium Channels; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Synapses | 1994 |
Translocation of protein phosphatase 1 catalytic subunits during 1,25-dihydroxyvitamin D3-induced monocytic differentiation of HL-60 cells.
Topics: Calcitriol; Catalysis; Cell Differentiation; Humans; Isoenzymes; Leukemia, Promyelocytic, Acute; Macromolecular Substances; Marine Toxins; Monocytes; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; RNA, Messenger; Translocation, Genetic | 1995 |
N-acetylsphingosine (C2-ceramide) inhibited neutrophil superoxide formation and calcium influx.
Topics: Alkaloids; Biological Transport, Active; Blood Proteins; Calcium; Enzyme Activation; Humans; In Vitro Techniques; Kinetics; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Spectrometry, Fluorescence; Sphingosine; Staurosporine; Superoxides | 1995 |
Regulation of Na+/H+ exchange activity by recruitment of new Na+/H+ antiporters: effect of calyculin A.
Topics: Acids; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Ethers, Cyclic; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Sodium-Hydrogen Exchangers; Temperature; Trout | 1995 |
Modulation of K(+)-Cl- cotransport in equine red blood cells.
Topics: Animals; Carboxylic Acids; Carrier Proteins; Chlorides; Dose-Response Relationship, Drug; Erythrocytes; Ethers, Cyclic; Female; Homeostasis; Horses; Hydrogen-Ion Concentration; Indenes; K Cl- Cotransporters; Magnesium; Male; Marine Toxins; Okadaic Acid; Oxazoles; Oxygen; Phosphates; Phosphoprotein Phosphatases; Potassium; Potassium Channels; Rubidium; Symporters | 1994 |
Okadaic acid increases nerve growth factor secretion, mRNA stability, and gene transcription in primary cultures of cortical astrocytes.
Topics: Animals; Animals, Newborn; Astrocytes; Blotting, Northern; Cell Nucleus; Cells, Cultured; Cerebral Cortex; DNA Probes; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Ethers, Cyclic; Gene Expression; Genes, fos; Genes, jun; Kinetics; Marine Toxins; Nerve Growth Factors; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; RNA, Messenger; Tetradecanoylphorbol Acetate; Time Factors; Transcription, Genetic | 1995 |
Phosphoprotein phosphatase 1 (PP1) is a component of the isolated sea urchin mitotic apparatus.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Cycle; Ethers, Cyclic; Female; Marine Toxins; Microtubule-Associated Proteins; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Processing, Post-Translational; Sea Urchins; Spindle Apparatus | 1994 |
RAG-1 and RAG-2 gene expression and V(D)J recombinase activity are enhanced by protein phosphatase 1 and 2A inhibition in lymphocyte cell lines.
Topics: Animals; B-Lymphocytes; Base Sequence; Cell Line; DNA Nucleotidyltransferases; DNA-Binding Proteins; Gene Rearrangement, B-Lymphocyte; Homeodomain Proteins; Marine Toxins; Mice; Molecular Sequence Data; Oxazoles; Phosphoprotein Phosphatases; Polymerase Chain Reaction; Protein Biosynthesis; Protein Phosphatase 1; Proteins; Recombination, Genetic; Transfection; Up-Regulation; VDJ Recombinases | 1995 |
Regulation of CD18 expression in human neutrophils as related to shape changes.
Topics: Amino Acid Sequence; Antigens, CD; CD18 Antigens; Cell Movement; Cell Size; Chemotactic Factors; Ethers, Cyclic; Humans; In Vitro Techniques; Indoles; Marine Toxins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oligopeptides; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Leukocyte-Adhesion; Tetradecanoylphorbol Acetate | 1993 |
A role for protein kinases and phosphatases in the Ca(2+)-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Electrophysiology; Ethers, Cyclic; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Protein Kinases; Receptors, AMPA; Synapses | 1994 |
Agents that promote protein phosphorylation inhibit the activity of the Na+/Ca2+ exchanger and prolong Ca2+ transients in bovine chromaffin cells.
Topics: Animals; Bucladesine; Calcium; Carrier Proteins; Cattle; Chromaffin System; Drug Synergism; Ethers, Cyclic; Fura-2; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Sodium-Calcium Exchanger | 1994 |
Activity-dependent enhancement of synaptic transmission in hippocampal slices treated with the phosphatase inhibitor calyculin A.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Evoked Potentials; Hippocampus; In Vitro Techniques; Kynurenic Acid; Marine Toxins; Neurons, Afferent; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 1994 |
Regulation of the beta-stimulation of the Na(+)-K+ pump current in guinea-pig ventricular myocytes by a cAMP-dependent PKA pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electric Conductivity; Guinea Pigs; Heart Ventricles; Isoproterenol; Isoquinolines; Male; Marine Toxins; Myocardium; Oxazoles; Phosphoprotein Phosphatases; Piperazines; Protein Kinase Inhibitors; Sodium-Potassium-Exchanging ATPase | 1994 |
Decreased protein phosphorylation induced by anoxia in proximal renal tubules.
Topics: Alkaloids; Animals; Benzophenanthridines; Ethers, Cyclic; Hypoxia; In Vitro Techniques; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Marine Toxins; Okadaic Acid; Oxazoles; Phenanthridines; Phosphates; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Proteins; Rabbits; Reference Values | 1994 |
Inhibition of protein phosphatases by okadaic acid and calyculin-A differentially modulates hormonal- and forskolin-stimulated formation of cyclic AMP in AtT-20 corticotrophs: effect of pituitary adenylate activating polypeptide and corticotropin-releasin
Topics: Adenylyl Cyclases; Adrenocorticotropic Hormone; Animals; Cell Line; Cells, Cultured; Colforsin; Corticotropin-Releasing Hormone; Cyclic AMP; Dose-Response Relationship, Drug; Ethers, Cyclic; Marine Toxins; Neuropeptides; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pituitary Adenylate Cyclase-Activating Polypeptide; Pituitary Gland, Anterior; Rats | 1994 |
Cleaved intracellular plasminogen activator inhibitor 2 in human myeloleukaemia cells is a marker of apoptosis.
Topics: Apoptosis; Biomarkers, Tumor; Bone Marrow; Cell Death; Ethers, Cyclic; Humans; Intracellular Fluid; Isomerism; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Promyelocytic, Acute; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Plasminogen Activator Inhibitor 2; Tumor Cells, Cultured | 1994 |
Effect of calyculin-A, phosphatase inhibitor, on 20 alpha-hydroxysteroid dehydrogenase activity in rat luteal cell culture.
Topics: 20-alpha-Hydroxysteroid Dehydrogenase; 20-Hydroxysteroid Dehydrogenases; Animals; Cells, Cultured; Corpus Luteum; Female; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Processing, Post-Translational; Pseudopregnancy; Rats; Rats, Wistar | 1993 |
Protein phosphatase inhibitors prolong Ca(2+)-transients and divalent cation-dependent action potentials in leech Retzius cells.
Topics: Action Potentials; Animals; Calcium; Cations, Divalent; Ethers, Cyclic; Fura-2; Ganglia, Invertebrate; Leeches; Marine Toxins; Membrane Potentials; Nerve Fibers; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Proteins | 1994 |
Signal transduction for nuclear factor-kappa B activation. Proposed location of antioxidant-inhibitable step.
Topics: Antioxidants; Base Sequence; Cell Line; Ethers, Cyclic; Humans; Marine Toxins; Molecular Sequence Data; NF-kappa B; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Reactive Oxygen Species; RNA, Messenger; Signal Transduction | 1994 |
Biochemical and electrophysiological mechanisms of the positive inotropic effect of calyculin A, a protein phosphatase inhibitor.
Topics: Animals; Calcium Channels; Calcium-Binding Proteins; Ethers, Cyclic; Guinea Pigs; In Vitro Techniques; Marine Toxins; Myocardial Contraction; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Stimulation, Chemical | 1994 |
Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors.
Topics: Alkaloids; Calcium; Down-Regulation; Ethers, Cyclic; Humans; Indoles; Leukotriene B4; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Signal Transduction; Staurosporine | 1994 |
Cyclic strain stimulates dephosphorylation of the 20kDa regulatory myosin light chain in vascular smooth muscle cells.
Topics: Animals; Cattle; Cell Adhesion; Cells, Cultured; Marine Toxins; Muscle Contraction; Muscle, Smooth, Vascular; Myosins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Stress, Mechanical | 1994 |
A mutant of protein phosphatase-1 that exhibits altered toxin sensitivity.
Topics: Amino Acid Sequence; Animals; DNA Primers; Ethers, Cyclic; Kinetics; Marine Toxins; Microcystins; Molecular Sequence Data; Mutagenesis, Site-Directed; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Rabbits; Recombinant Fusion Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Structure-Activity Relationship | 1994 |
Calyculin A and okadiac acid inhibit human platelet aggregation by blocking protein phosphatases types 1 and 2A.
Topics: Blood Platelets; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Humans; Immunoblotting; Marine Toxins; Myosins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Aggregation Inhibitors; Serotonin | 1994 |
Characterization of natural toxins with inhibitory activity against serine/threonine protein phosphatases.
Topics: Animals; Antifungal Agents; Cattle; Cyclic AMP-Dependent Protein Kinases; Esterification; Ethers, Cyclic; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Oxidation-Reduction; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylase b; Phosphorylase Kinase; Pyrans; Rabbits; Spiro Compounds | 1994 |
Phosphatase inhibitors suppress Ca2+ influx induced by receptor-mediated intracellular Ca2+ store depletion in human platelets.
Topics: Antifungal Agents; Blood Platelets; Calcium; Ethers, Cyclic; Humans; In Vitro Techniques; Magnesium; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Platelet Aggregation Inhibitors; Pyrans; Spiro Compounds; Terpenes; Thapsigargin; Thrombin | 1994 |
Endocytosis and uptake of lucifer yellow by cultured atrial myocytes and isolated intact atria from adult rats. Regulation and subcellular localization.
Topics: Animals; Caffeine; Cells, Cultured; Coated Pits, Cell-Membrane; Endocytosis; Fluorescent Dyes; Heart Atria; In Vitro Techniques; Isoquinolines; Male; Marine Toxins; Myocardium; Oxazoles; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Tissue Distribution | 1994 |
Increased phosphorylation of the amino-terminal domain of the low molecular weight neurofilament subunit in okadaic acid-treated neurons.
Topics: Animals; Blotting, Western; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Ethers, Cyclic; Ganglia, Spinal; Macromolecular Substances; Marine Toxins; Neurofilament Proteins; Neurons; Okadaic Acid; Oxazoles; Peptide Fragments; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Rats | 1994 |
Target cell-induced inactivation of cytolytic lymphocytes. Role and regulation of CD45 and calyculin A-inhibited phosphatase in response to interleukin-2.
Topics: Adult; Cell Compartmentation; Cytotoxicity, Immunologic; Humans; Immunity, Cellular; In Vitro Techniques; Interleukin-2; Killer Cells, Natural; Kinetics; Leukocyte Common Antigens; Lymphocyte Activation; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; T-Lymphocytes, Cytotoxic | 1994 |
Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets.
Topics: Animals; Azepines; Blood Platelets; Calcium; Cations, Divalent; Indoles; Inositol 1,4,5-Trisphosphate; Ionomycin; Maleimides; Manganese; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Platelet Activating Factor; Protein Kinase C; Rabbits; Signal Transduction; Triazoles | 1994 |
Na(+)-K(+)-Cl- cotransporter of brain capillary endothelial cells. Properties and regulation by endothelins, hyperosmolar solutions, calyculin A, and interleukin-1.
Topics: Amino Acid Sequence; Animals; Biological Transport; Brain; Capillaries; Carrier Proteins; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP-Dependent Protein Kinases; Endothelins; Endothelium, Vascular; Interleukin-1; Marine Toxins; Membrane Proteins; Molecular Sequence Data; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Rats; Signal Transduction; Sodium-Potassium-Chloride Symporters | 1994 |
Regulation of ROMK1 K+ channel activity involves phosphorylation processes.
Topics: Adenosine Triphosphate; Animals; Cloning, Molecular; Cyclic AMP-Dependent Protein Kinases; Ethers, Cyclic; Female; Ion Channel Gating; Kidney; Kinetics; Magnesium; Marine Toxins; Membrane Potentials; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Potassium Channels; Potassium Channels, Inwardly Rectifying; Rats; Time Factors; Vanadates; Xenopus | 1994 |
Presence of protein phosphatase type 1 and its involvement in temperature-dependent flagellar movement of fowl spermatozoa.
Topics: Animals; Blotting, Western; Chickens; Ethers, Cyclic; Hot Temperature; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Sperm Motility; Sperm Tail; Spermatozoa | 1994 |
Modulation of nucleocytosolic [Ca2+] gradient in smooth muscle by protein phosphorylation.
Topics: Adenosine Triphosphate; Animals; Benzoquinones; Calcium; Cell Line; Cell Nucleus; Colforsin; Cricetinae; Cytosol; Diacylglycerol Kinase; Epidermal Growth Factor; Ethers, Cyclic; Homeostasis; Kinetics; Lactams, Macrocyclic; Leiomyosarcoma; Marine Toxins; Mesocricetus; Models, Biological; Muscle, Smooth; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperidines; Protein Kinase C; Protein Kinases; Protein Tyrosine Phosphatases; Quinazolines; Quinazolinones; Quinones; Rifabutin; Tetradecanoylphorbol Acetate; Time Factors; Tumor Cells, Cultured | 1994 |
Characterization of the proteins of the intestinal Na(+)-K(+)-2Cl- cotransporter.
Topics: Affinity Labels; Animals; Benzophenones; Biological Transport; Carrier Proteins; Flounder; Immunoblotting; Intestinal Mucosa; Ions; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Sodium-Potassium-Chloride Symporters; Sulfanilamides | 1994 |
In vitro neutralization of the inhibitory effect of Microcystin-LR to protein phosphatase 2A by antibody against the toxin.
Topics: Animals; Antibodies; Antibody Specificity; Ethers, Cyclic; Marine Toxins; Mice; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rabbits | 1994 |
Multidrug-resistant human KB carcinoma cells are highly resistant to the protein phosphatase inhibitors okadaic acid and calyculin A. Analysis of potential mechanisms involved in toxin resistance.
Topics: Affinity Labels; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Survival; Drug Resistance; Ethers, Cyclic; Humans; KB Cells; Marine Toxins; Membrane Glycoproteins; Neoplasm Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Photochemistry; Verapamil | 1993 |
Desensitization of cholecystokininB receptors in GH3 cells.
Topics: Alkaloids; Calcium; Drug Tolerance; Enzyme Activation; Inositol 1,4,5-Trisphosphate; Marine Toxins; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoric Monoester Hydrolases; Pituitary Neoplasms; Protein Kinase C; Receptors, Cholecystokinin; Sincalide; Staurosporine; Thyrotropin-Releasing Hormone; Tumor Cells, Cultured | 1994 |
The coupling of multiple signal transduction pathways with steroid response mechanisms.
Topics: Dexamethasone; Drug Synergism; Ethers, Cyclic; Gene Expression Regulation; Genes, Reporter; Glucocorticoids; Growth Substances; Humans; Luciferases; Marine Toxins; Okadaic Acid; Oxazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Phosphotransferases; Promoter Regions, Genetic; Protein Kinases; Protein Phosphatase 1; Signal Transduction; Time Factors | 1994 |
Staurosporine, a protein kinase inhibitor, activates K-Cl cotransport in LK sheep erythrocytes.
Topics: Alkaloids; Animals; Carrier Proteins; Erythrocytes; K Cl- Cotransporters; Magnesium; Marine Toxins; Osmolar Concentration; Oxazoles; Oxidation-Reduction; Phosphoprotein Phosphatases; Potassium; Protein Kinase Inhibitors; Sheep; Staurosporine; Symporters; Tetradecanoylphorbol Acetate; Time Factors | 1994 |
Protein phosphatase inhibitors induce the release of serotonin from rat basophilic leukemia cells (RBL-2H3).
Topics: Alkaloids; Animals; Calcium; Ethers, Cyclic; Leukemia, Basophilic, Acute; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Rats; Serotonin; Staurosporine; Tumor Cells, Cultured | 1994 |
Enhancement of X-ray cell killing in cultured mammalian cells by the protein phosphatase inhibitor calyculin A.
Topics: Animals; Carcinogens; Cell Line; Cell Survival; Chromosomes; Cricetinae; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Kinetics; Marine Toxins; Mesocricetus; Oxazoles; Protein Tyrosine Phosphatases; Time Factors; X-Rays | 1994 |
Regulation of NMDA receptors in cultured hippocampal neurons by protein phosphatases 1 and 2A.
Topics: Cells, Cultured; Ethers, Cyclic; Glycine; Hippocampus; Marine Toxins; Membrane Potentials; N-Methylaspartate; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Receptors, N-Methyl-D-Aspartate | 1994 |
Inhibitors of serine/threonine phosphatases enhance phosphorylation of the interferon-gamma receptor while selectively attenuating interferon-gamma-induced gene expression in human peripheral-blood monocytes.
Topics: Base Sequence; Ethers, Cyclic; Gene Expression Regulation; Genes, Immediate-Early; Humans; In Vitro Techniques; Interferon gamma Receptor; Interferon-gamma; Marine Toxins; Molecular Sequence Data; Monocytes; Okadaic Acid; Oligodeoxyribonucleotides; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Receptors, Interferon | 1994 |
Two glucose-signaling pathways in S14 gene transcription in primary hepatocytes: a common role of protein phosphorylation.
Topics: Animals; Cells, Cultured; Ethers, Cyclic; Glucose; Liver; Male; Mammary Tumor Virus, Mouse; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Promoter Regions, Genetic; Protein Phosphatase 1; Protein Phosphatase 2; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Thyroid Hormone; Signal Transduction; Thymidine Kinase; Transcription Factors; Transcription, Genetic; Transfection | 1994 |
Characterization of serine/threonine protein phosphatases in RINm5F insulinoma cells.
Topics: Animals; Ethers, Cyclic; In Vitro Techniques; Insulinoma; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Pancreatic Neoplasms; Peptides, Cyclic; Phosphoprotein Phosphatases; Rabbits; Rats; Tumor Cells, Cultured | 1993 |
Cytosolic protein phosphatase may turn off activated NADPH oxidase in guinea pig neutrophils.
Topics: Animals; Cytosol; Enzyme Activation; Ethers, Cyclic; Female; Guinea Pigs; Kinetics; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Superoxides; Tetradecanoylphorbol Acetate | 1993 |
Inhibition of initiation of DNA replication in Xenopus egg extracts by a phosphatase inhibitor, calyculin A.
Topics: Animals; Cell Nucleus; Cell-Free System; DNA Replication; Male; Marine Toxins; Mitosis; Ovum; Oxazoles; Periodicity; Phosphoprotein Phosphatases; Spermatozoa; Xenopus | 1993 |
Differential effects of calyculin A and okadaic acid on the glucose-induced regulation of glycogen synthase and phosphorylase activities in cultured hepatocytes.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Ethers, Cyclic; Glucose; Glycogen; Glycogen Synthase; Liver; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylases; Rats; Rats, Sprague-Dawley; Up-Regulation | 1993 |
Changes in the cytoskeletal structure of cultured smooth muscle cells induced by calyculin-A.
Topics: Actin Cytoskeleton; Actins; Animals; Calcium; Cell Line; Cytoskeleton; Cytosol; Egtazic Acid; Marine Toxins; Microscopy, Electron, Scanning; Microtubules; Muscle, Smooth, Vascular; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Vinculin | 1993 |
Phosphatase inhibitors, gap junctional intercellular communication and [125I]-EGF binding in hamster fibroblasts.
Topics: Aluminum Compounds; Animals; Cell Communication; Cell Line; Connexin 43; Cricetinae; Cricetulus; Embryo, Mammalian; Epidermal Growth Factor; Ethers, Cyclic; Fibroblasts; Fluorides; Intercellular Junctions; Iodine Radioisotopes; Kinetics; Lung; Marine Toxins; Mesocricetus; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tetradecanoylphorbol Acetate; Vanadates; Vanadium Compounds | 1993 |
Protein phosphatase activity is required for light-inducible gene expression in maize.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chloramphenicol O-Acetyltransferase; Chlorophyll; Cloning, Molecular; Conserved Sequence; DNA Primers; Electroporation; Ethers, Cyclic; Gene Expression Regulation; Kinetics; Light; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Phosphatase 1; Protoplasts; Pyruvate, Orthophosphate Dikinase; Rabbits; Recombinant Fusion Proteins; Ribulose-Bisphosphate Carboxylase; Sequence Homology, Amino Acid; Transcription, Genetic; Transcriptional Activation; Zea mays | 1993 |
Role of protein phosphorylation in TNF-induced apoptosis: phosphatase inhibitors synergize with TNF to activate DNA fragmentation in normal as well as TNF-resistant U937 variants.
Topics: Alkaloids; Apoptosis; Breast Neoplasms; Carbazoles; DNA; Drug Synergism; Ethers, Cyclic; Humans; Indoles; Lymphoma, Large B-Cell, Diffuse; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Prostatic Neoplasms; Protein Kinase Inhibitors; Recombinant Proteins; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Phosphorylation and disruption of intermediate filament proteins in oligodendrocyte precursor cultures treated with calyculin A.
Topics: Amino Acids; Animals; Animals, Newborn; Blotting, Western; Cells, Cultured; Cytoskeleton; Densitometry; Fluorescent Antibody Technique; Intermediate Filament Proteins; Marine Toxins; Nerve Tissue Proteins; Nestin; Oligodendroglia; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Stem Cells; Subcellular Fractions; Vimentin | 1993 |
Okadaic acid inhibits glucocorticoid-induced apoptosis in T cell hybridomas at its late stage.
Topics: Animals; Apoptosis; Binding Sites; Dexamethasone; DNA; Electrophoresis, Agar Gel; Ethers, Cyclic; Hybridomas; Luciferases; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Plasmids; Protein Phosphatase 1; Receptors, Glucocorticoid; T-Lymphocytes; Transfection | 1993 |
Phosphorylation of vimentin in the C-terminal domain after exposure to calyculin-A.
Topics: 3T3 Cells; Animals; Chymotrypsin; Cyclic AMP-Dependent Protein Kinases; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Thrombin; Vimentin | 1993 |
Increase of labeling indices in gastrointestinal mucosae of mice and rats by compounds of the okadaic acid type.
Topics: Administration, Oral; Animals; Antifungal Agents; Bromodeoxyuridine; Carcinogens; Cell Division; Dose-Response Relationship, Drug; Ethers, Cyclic; Intestinal Mucosa; Male; Marine Toxins; Mice; Mice, Inbred ICR; Okadaic Acid; Oxazoles; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Time Factors | 1994 |
Okadaic acid-dependent induction of the urokinase-type plasminogen activator gene associated with stabilization and autoregulation of c-Jun.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Base Sequence; Binding Sites; Blotting, Southern; Blotting, Western; Cell Line; Chloramphenicol O-Acetyltransferase; Colchicine; Cycloheximide; DNA Mutational Analysis; DNA-Binding Proteins; Enzyme Induction; Ethers, Cyclic; Gene Expression Regulation, Enzymologic; Genes, Regulator; Homeostasis; Kinetics; Marine Toxins; Molecular Sequence Data; Nuclear Proteins; Okadaic Acid; Oligodeoxyribonucleotides; Oxazoles; Phosphorylation; Protein Phosphatase 2; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-jun; Time Factors; Transcriptional Activation; Transfection; Urokinase-Type Plasminogen Activator | 1994 |
Characterization of the endogenous Na(+)-K(+)-2Cl- cotransporter in Xenopus oocytes.
Topics: Animals; Bumetanide; Carrier Proteins; Intracellular Membranes; Marine Toxins; Oocytes; Osmolar Concentration; Oxazoles; Sodium-Potassium-Chloride Symporters; Xenopus laevis | 1994 |
Phosphorylation down-regulates the store-operated Ca2+ entry pathway of human neutrophils.
Topics: Calcium; Calcium-Transporting ATPases; Ethers, Cyclic; Humans; In Vitro Techniques; Manganese; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Terpenes; Thapsigargin | 1994 |
The ATP and Mg2+ dependence of Na(+)-K(+)-2Cl- cotransport reflects a requirement for protein phosphorylation: studies using calyculin A.
Topics: Adenosine Triphosphate; Animals; Biological Transport, Active; Carrier Proteins; Chlorides; Cyclic AMP; Ducks; Erythrocytes; Hypertonic Solutions; In Vitro Techniques; Magnesium; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Potassium; Sodium; Sodium-Potassium-Chloride Symporters | 1993 |
Calyculin A, protein phosphatase inhibitor, enhances capacitation of human sperm.
Topics: Acrosome; Chlortetracycline; Ethers, Cyclic; Fluorescence; Humans; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Sperm Capacitation; Spermatozoa | 1993 |
Calyculin A, a potent inhibitor of phosphatases-1 and -2A, prevents apoptosis.
Topics: Apoptosis; Burkitt Lymphoma; DNA Damage; DNA, Neoplasm; Dose-Response Relationship, Drug; Gamma Rays; Humans; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Tumor Cells, Cultured | 1993 |
K-Cl cotransport in rabbit red cells: further evidence for regulation by protein phosphatase type 1.
Topics: Animals; Biological Transport; Carrier Proteins; Dose-Response Relationship, Drug; Erythrocytes; Ethylmaleimide; K Cl- Cotransporters; Marine Toxins; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Rabbits; Symporters; Time Factors | 1993 |
Calcium influx and protein phosphorylation mediate the metabolic stabilization of synaptic acetylcholine receptors in muscle.
Topics: Alkaloids; Animals; Bucladesine; Calcium; Calcium Channels; Cyclic AMP; Dibutyryl Cyclic GMP; Dihydropyridines; Electric Stimulation; Ethers, Cyclic; Kinetics; Male; Marine Toxins; Motor Endplate; Muscle Denervation; Muscles; Okadaic Acid; Organ Culture Techniques; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Potassium Chloride; Protein Kinase Inhibitors; Protein Kinases; Rats; Rats, Sprague-Dawley; Receptors, Cholinergic; Staurosporine; Synapses; Tetrodotoxin; Time Factors | 1993 |
Neutrophils stimulated with a chemotactic peptide or a phorbol ester exhibit different alterations in the activities of a battery of protein kinases.
Topics: Animals; Ethers, Cyclic; Guinea Pigs; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Substrate Specificity; Tetradecanoylphorbol Acetate | 1993 |
Dual effect of phosphatase inhibitors on calcium channels in intestinal smooth muscle cells.
Topics: Animals; Barium; Calcium Channels; Colon; Dose-Response Relationship, Drug; Electric Conductivity; Ethers, Cyclic; Guinea Pigs; Marine Toxins; Muscle, Smooth; Okadaic Acid; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation | 1993 |
Long-term potentiation is associated with an increased activity of Ca2+/calmodulin-dependent protein kinase II.
Topics: Animals; Animals, Newborn; Calcium-Calmodulin-Dependent Protein Kinases; Electric Stimulation; Evoked Potentials; Hippocampus; Kinetics; Male; Marine Toxins; Neurons; Organ Culture Techniques; Oxazoles; Phosphoprotein Phosphatases; Protein Kinases; Pyramidal Tracts; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Valine | 1993 |
Phosphatase inhibition by calyculin A increases i(f) in canine Purkinje fibers and myocytes.
Topics: Animals; Cell Membrane; Dogs; Electric Conductivity; Female; Heart; Kinetics; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Purkinje Fibers | 1993 |
Hepatocyte DNA replication is abolished by inhibitors selecting protein phosphatase 2A rather than phosphatase 1.
Topics: Animals; Cell Cycle; Cell Survival; DNA Replication; Ethers, Cyclic; Liver; Male; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Oxidation-Reduction; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinases; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Wistar | 1993 |
Okadaic acid-induced actin assembly in neutrophils: role of protein phosphatases.
Topics: Actins; Adenosine Triphosphate; Cell Movement; Cytoskeleton; Ethers, Cyclic; GTP-Binding Proteins; Humans; Marine Toxins; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Molecular Weight; Myosin-Light-Chain Kinase; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Protein Kinase C; Protein Kinases; Receptors, Cell Surface | 1993 |
The possible involvement of protein phosphatase 1 in thrombin-induced Ca2+ influx of human platelets.
Topics: Antifungal Agents; Blood Platelets; Calcium; Calcium Channels; Ethers, Cyclic; Humans; Manganese; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Platelet Aggregation; Protein Phosphatase 1; Pyrans; Spiro Compounds; Thrombin | 1993 |
Inhibition of hepatocytic autophagy by okadaic acid and other protein phosphatase inhibitors.
Topics: Animals; Autophagy; Cytoskeleton; Energy Metabolism; Ethers, Cyclic; Liver; Lysosomes; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinases; Proteins; Raffinose; Rats; Rats, Wistar; Vacuoles | 1993 |
Intracellular ATP and GTP are both required to preserve modulation of N-type calcium channel current by norepinephrine.
Topics: Adenosine Triphosphate; Animals; Binding Sites; Calcium Channels; Ethers, Cyclic; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Kinetics; Marine Toxins; Neurons; Norepinephrine; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rana catesbeiana; Sympathetic Nervous System; Vasoconstrictor Agents | 1993 |
An essential role for protein phosphatases in hippocampal long-term depression.
Topics: Animals; Calcium; Calmodulin; Electric Stimulation; Ethers, Cyclic; Hippocampus; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission | 1993 |
Effects of calyculin A on tension and myosin phosphorylation in skinned smooth muscle of the rabbit mesenteric artery.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; In Vitro Techniques; Inosine Triphosphate; Isometric Contraction; Male; Marine Toxins; Mesenteric Arteries; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Myosins; Oxazoles; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Rabbits; Vasoconstrictor Agents | 1993 |
Calyculin A inhibits the exposure of fibrinogen receptor in thrombin-stimulated platelets.
Topics: Adult; Blood Platelets; Dose-Response Relationship, Drug; Ethers, Cyclic; Humans; In Vitro Techniques; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Phosphatase 1; Thrombin | 1993 |
Role of protein kinase C in the phosphorylation of cardiac myosin light chain 2.
Topics: Adenosine Triphosphate; Animals; Calcium; Cattle; Diacetyl; Electrophoresis, Polyacrylamide Gel; Kinetics; Marine Toxins; Myocardium; Myosin-Light-Chain Kinase; Myosins; Oxazoles; Peptide Mapping; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Trypsin | 1993 |
Inhibition of an archaeal protein phosphatase activity by okadaic acid, microcystin-LR, or calyculin A.
Topics: Enzyme Activation; Ethers, Cyclic; Marine Toxins; Methanosarcina; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Species Specificity; Substrate Specificity | 1993 |
Glucose transport in L6 myoblasts overexpressing GLUT1 and GLUT4.
Topics: Animals; Biological Transport; Cell Membrane; Cells, Cultured; Deoxyglucose; Ethers, Cyclic; Glucose; Glucose Transporter Type 1; Glucose Transporter Type 4; Humans; Insulin; Marine Toxins; Monosaccharide Transport Proteins; Muscle Proteins; Muscles; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats | 1993 |
Bradykinin-stimulated transient modulation of epidermal growth factor receptors in A-431 human epidermoid carcinoma cells.
Topics: Alkaloids; Binding, Competitive; Bradykinin; Carcinoma, Squamous Cell; ErbB Receptors; Humans; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Staurosporine; Tumor Cells, Cultured | 1993 |
Protein phosphatase inhibitors induce the selective breakdown of stable microtubules in fibroblasts and epithelial cells.
Topics: 3T3 Cells; Animals; Cell Line; Chlorocebus aethiops; Epithelium; Ethers, Cyclic; Fibroblasts; Kidney; Kinetics; Marine Toxins; Mice; Microtubules; Nocodazole; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Time Factors; Tubulin | 1993 |
Regulation by cell volume of Na(+)-K(+)-2Cl- cotransport in vascular endothelial cells: role of protein phosphorylation.
Topics: Animals; Aorta; Carbazoles; Carrier Proteins; Cattle; Cells, Cultured; Endothelium, Vascular; Ethers, Cyclic; Indole Alkaloids; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Proteins; Sodium-Potassium-Chloride Symporters; Vasoconstrictor Agents | 1993 |
Involvement of protein kinase C and of protein phosphatases 1 and/or 2A in p47 phox phosphorylation in formylmet-Leu-Phe stimulated neutrophils: studies with selective inhibitors RO 31-8220 and calyculin A.
Topics: Calcimycin; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Indoles; Ionophores; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C | 1995 |
Inhibition of protein phosphatase 1 stimulates secretion of Alzheimer amyloid precursor protein.
Topics: Aged; Alzheimer Disease; Amyloid; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Cantharidin; Cell Line; Endopeptidases; Enzyme Inhibitors; Ethers, Cyclic; Humans; Immunoblotting; Marine Toxins; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Prion Proteins; Prions; Protein Phosphatase 1; Protein Precursors | 1995 |
A role for protein phosphorylation in modulating Ca2+ elevation in rabbit platelets treated with thapsigargin.
Topics: Animals; Blood Platelets; Blood Proteins; Calcium; Calcium-Transporting ATPases; Cell Membrane; Cyclooxygenase Inhibitors; Enzyme Activation; Enzyme Inhibitors; Heparin; Inositol 1,4,5-Trisphosphate; Intracellular Fluid; Manganese; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rabbits; Signal Transduction; Terpenes; Tetradecanoylphorbol Acetate; Thapsigargin | 1996 |
The protein phosphatase inhibitor calyculin-A affects catecholamine secretion and granular distribution in cultured adrenomedullary chromaffin cells.
Topics: Adrenal Medulla; Animals; Basal Metabolism; Catecholamines; Cattle; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Chromaffin Granules; Digitonin; Enzyme Inhibitors; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Proteins; Secretory Rate | 1995 |
Ability of okadaic acid and other protein phosphatase inhibitors to mimic the stimulatory effects of 12-O-tetradecanoylphorbol-13-acetate on hydroperoxide production in mouse epidermis in vivo.
Topics: Animals; Carcinogens; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers, Cyclic; Female; Hydrogen Peroxide; Marine Toxins; Mice; Mice, Inbred Strains; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Skin; Stimulation, Chemical; Tetradecanoylphorbol Acetate | 1996 |
Involvement of protein phosphatase-1 in cytoskeletal organization of cultured endothelial cells.
Topics: Actins; Animals; Blotting, Western; Carbazoles; Cell Nucleus; Cells, Cultured; Cytoskeleton; Endothelium, Vascular; Enzyme Inhibitors; Humans; Indole Alkaloids; Marine Toxins; Mice; Microtubules; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Protein Kinase Inhibitors; Protein Phosphatase 1; Umbilical Veins | 1995 |
Effects of the protein phosphatase inhibitors, tautomycin and calyculin-A, on protein phosphorylation and cytoskeleton of human platelets.
Topics: Adult; Antifungal Agents; Blood Platelets; Blotting, Western; Calcium; Cytoskeleton; Cytosol; Enzyme Inhibitors; Humans; Marine Toxins; Microscopy, Electron; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Pyrans; Spiro Compounds | 1995 |
Involvement of several protein kinases in the phosphorylation of p47-phox.
Topics: Amino Acid Sequence; Animals; Enzyme Inhibitors; Guinea Pigs; Kinetics; Marine Toxins; Mice; Molecular Sequence Data; Multienzyme Complexes; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Oxazoles; Peptide Fragments; Phosphopeptides; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Kinases; Tetradecanoylphorbol Acetate | 1996 |
Molecular mechanisms of TNFalpha cytotoxicity: activation of NF-kappaB and nuclear translocation.
Topics: Animals; Base Sequence; Biological Transport; Cell Compartmentation; Cell Nucleus; DNA-Binding Proteins; Enzyme Inhibitors; Fibrosarcoma; I-kappa B Proteins; Marine Toxins; Mice; Molecular Sequence Data; Naphthalenes; NF-kappa B; NF-KappaB Inhibitor alpha; Oxazoles; Phosphoprotein Phosphatases; Protein Binding; Protein Kinase Inhibitors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
d-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties.
Topics: Amino Acid Sequence; Animals; Antioxidants; Aorta; Cell Cycle; Cell Division; Cell Line; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethers, Cyclic; Flow Cytometry; Isomerism; Kinetics; Marine Toxins; Molecular Sequence Data; Muscle, Smooth, Vascular; Naphthalenes; Okadaic Acid; Oligopeptides; Oxazoles; Protein Kinase C; Rats; Substrate Specificity; Tetradecanoylphorbol Acetate; Thymidine; Vitamin E | 1995 |
Regulation of the nuclear factor of activated T cells in stably transfected Jurkat cell clones.
Topics: Alkaline Phosphatase; Bucladesine; Clone Cells; Colforsin; Cyclosporine; Dinoprostone; DNA-Binding Proteins; Enzyme Inhibitors; Ethers, Cyclic; Female; Humans; Immunosuppressive Agents; Kinetics; Lymphocyte Activation; Marine Toxins; NFATC Transcription Factors; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Placenta; Pregnancy; Protein Phosphatase 1; Recombinant Proteins; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription Factors; Transfection; Tumor Cells, Cultured | 1996 |
Phosphorylation of beta III-tubulin.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Antibodies, Monoclonal; Brain; Cattle; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Erythrocytes; Escherichia coli; Glycerol; Humans; Marine Toxins; Microtubule-Associated Proteins; Microtubules; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorylation; Protein Conformation; Protein Phosphatase 2; Tubulin | 1996 |
Reconstitution of calyculin-inhibited K-Cl cotransport in dog erythrocyte ghosts by exogenous PP-1.
Topics: Animals; Carrier Proteins; Chlorides; Dogs; Enzyme Inhibitors; Erythrocyte Membrane; K Cl- Cotransporters; Kinetics; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Potassium; Symporters | 1996 |
Tumor cell resistance to apoptosis due to a defect in the activation of sphingomyelinase and the 24 kDa apoptotic protease (AP24).
Topics: Apoptosis; DNA; Enzyme Activation; Ethers, Cyclic; Humans; Lymphoma, Large B-Cell, Diffuse; Marine Toxins; Okadaic Acid; Oxazoles; Serine Endopeptidases; Sphingomyelin Phosphodiesterase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Ultraviolet Rays | 1996 |
The effect of okadaic acid and calyculin A on cholesterol esterification in rat hepatocytes.
Topics: Animals; Cholesterol Esters; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Female; In Vitro Techniques; Kinetics; Liver; Marine Toxins; Okadaic Acid; Oxazoles; Perfusion; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase | 1995 |
The phosphatase inhibitor calyculin antagonizes the rapid initiation of apoptosis by photodynamic therapy.
Topics: Animals; Apoptosis; Depsipeptides; Drug Interactions; Marine Toxins; Mice; Microscopy, Electron; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Photochemotherapy; Protein Kinase C; Tumor Cells, Cultured | 1996 |
Multiple structural domains within I kappa B alpha are required for its inducible degradation by both cytokines and phosphatase inhibitors.
Topics: Amino Acid Sequence; DNA-Binding Proteins; Enzyme Inhibitors; Epitopes; HeLa Cells; Humans; I-kappa B Proteins; Kinetics; Marine Toxins; Molecular Sequence Data; NF-kappa B; NF-KappaB Inhibitor alpha; Oxazoles; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Recombinant Proteins; Serine; Transfection; Trypsin; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1996 |
The effects of oxygenation upon the Cl-dependent K flux pathway in equine red cells.
Topics: Acids; Animals; Chlorides; Enzyme Inhibitors; Erythrocyte Volume; Erythrocytes; Ethylmaleimide; Female; Horses; Male; Marine Toxins; Oxazoles; Oxygen; Partial Pressure; Phosphoprotein Phosphatases; Potassium | 1996 |
Regulation of myosin phosphatase by Rho and Rho-associated kinase (Rho-kinase)
Topics: 3T3 Cells; Actins; Amino Acid Sequence; Animals; Cattle; GTP Phosphohydrolases; GTP-Binding Proteins; Intracellular Signaling Peptides and Proteins; Isopropyl Thiogalactoside; Marine Toxins; Mice; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein | 1996 |
Platelet-derived growth factor induces a long-term inhibition of N-methyl-D-aspartate receptor function.
Topics: Analysis of Variance; Animals; Cells, Cultured; Enzyme Inhibitors; Evoked Potentials; Female; Hippocampus; Humans; In Vitro Techniques; Kinetics; Male; Marine Toxins; Models, Biological; Neurons; Oocytes; Oxazoles; Patch-Clamp Techniques; Phalloidine; Platelet-Derived Growth Factor; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Time Factors; Xenopus | 1996 |
Adenosine A2 receptor occupancy regulates stimulated neutrophil function via activation of a serine/threonine protein phosphatase.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Analysis of Variance; Carbazoles; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Humans; In Vitro Techniques; Indoles; Kinetics; Marine Toxins; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Purinergic P1 Receptor Agonists; Pyrroles; Superoxides | 1996 |
The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis.
Topics: Acids; Apoptosis; Caenorhabditis elegans Proteins; Cantharidin; Caspase 1; Caspases; Cysteine Endopeptidases; DNA; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; Etoposide; Helminth Proteins; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Phosphatase 1; Protein Phosphatase 2; Retinoblastoma Protein; S Phase; Tumor Cells, Cultured | 1996 |
Alpha-subunit of farnesyltransferase is phosphorylated in vivo: effect of protein phosphatase-1 on enzymatic activity.
Topics: Alkyl and Aryl Transferases; Animals; Antibody Specificity; Cell Line; Cytosol; Enzyme Inhibitors; Farnesyltranstransferase; Immunoblotting; Immunoglobulin G; Kinetics; Macromolecular Substances; Marine Toxins; Oxazoles; PC12 Cells; Phosphates; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Rats; Transferases | 1996 |
Reversible phosphorylation as a controlling factor for sustaining calcium oscillations in HeLa cells: Involvement of calmodulin-dependent kinase II and a calyculin A-inhibitable phosphatase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Amino Acid Sequence; Binding Sites; Calcium; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calcium-Transporting ATPases; Enzyme Inhibitors; Ethers, Cyclic; HeLa Cells; Histamine; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Isoquinolines; Maleimides; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Piperazines; Protein Kinase C; Receptors, Cytoplasmic and Nuclear; Ryanodine; Spectrometry, Fluorescence; Staurosporine; Sulfonamides | 1996 |
Inhibitors of serine/threonine phosphoprotein phosphatases alter circadian properties in Gonyaulax polyedra.
Topics: Animals; Cantharidin; Cells, Cultured; Circadian Rhythm; Dinoflagellida; Enzyme Inhibitors; Ethers, Cyclic; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1 | 1996 |
Phosphorylation is involved in the regulation of the taurine influx via the beta-system in Ehrlich ascites tumor cells.
Topics: Animals; Binding Sites; Biological Transport, Active; Bucladesine; Carcinoma, Ehrlich Tumor; Cell Size; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Enzyme Inhibitors; Female; Marine Toxins; Membrane Potentials; Mice; Models, Biological; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Taurine; Tetradecanoylphorbol Acetate | 1996 |
Photosensitization of oesophageal smooth muscle by 3-NO2-1, 4-dihydropyridines: evidence for two cyclic GMP-dependent effector pathways.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 3',5'-Cyclic-GMP Phosphodiesterases; Aminoquinolines; Animals; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Calcium-Transporting ATPases; Chelating Agents; Egtazic Acid; Esophagus; Guanylate Cyclase; In Vitro Techniques; Indoles; Marine Toxins; Muscle, Smooth; Nicotinic Acids; Nitric Oxide; Oxadiazoles; Oxazoles; Phosphoprotein Phosphatases; Photosensitizing Agents; Purinones; Rats; Rats, Sprague-Dawley; Ryanodine | 1995 |
Effect of arachidonic acid on the L-type calcium current in frog cardiac myocytes.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acid; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; In Vitro Techniques; Indomethacin; Isoproterenol; Lipoxygenase Inhibitors; Marine Toxins; Myocardium; Myristic Acid; Myristic Acids; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rana catesbeiana | 1996 |
Overexpressed tau protein in cultured cells is phosphorylated without formation of PHF: implication of phosphoprotein phosphatase involvement.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Marine Toxins; Microtubule-Associated Proteins; Mitogen-Activated Protein Kinase Kinases; Neurofibrillary Tangles; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Rats; tau Proteins; Transfection | 1995 |
Protein phosphatase inhibitors potentiate Ca2+/calmodulin-dependent protein kinase II activity in rat pancreatic acinar cells.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cholecystokinin; Cyclosporine; Enzyme Activation; Enzyme Inhibitors; Ethers, Cyclic; In Vitro Techniques; Male; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley | 1996 |
Stimulation of the ceramide pathway partially mimics lipopolysaccharide-induced responses in murine peritoneal macrophages.
Topics: Animals; Carrier Proteins; Ceramides; Chemokine CXCL10; Chemokines, CXC; Cytokines; Enzyme Inhibitors; Interferon Regulatory Factors; Interferons; Lipopolysaccharides; Macrophage Activation; Macrophages, Peritoneal; Marine Toxins; Mice; Mice, Inbred C3H; Oxazoles; Phosphoprotein Phosphatases; Repressor Proteins; Second Messenger Systems; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha | 1996 |
Role of protein kinases in regulating sheep erythrocyte K-Cl cotransport.
Topics: Adenosine Triphosphate; Animals; Benzylidene Compounds; Carrier Proteins; Erythrocytes; Ethylmaleimide; Genistein; Isoflavones; K Cl- Cotransporters; Marine Toxins; Nitriles; Oxazoles; Protein Kinases; Sheep; Staurosporine; Symporters; Tyrphostins | 1996 |
Role for protein phosphatase in the regulation of Ca2+ influx in parotid gland acinar cells.
Topics: Animals; Calcium; Carbachol; Enzyme Inhibitors; Male; Manganese; Marine Toxins; Okadaic Acid; Oxazoles; Parotid Gland; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Rats; Rats, Wistar; Stimulation, Chemical; Thapsigargin; Vanadates | 1996 |
Protein tyrosine phosphorylation and the regulation of KCl cotransport in trout erythrocytes.
Topics: Animals; Carrier Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Genistein; Isoflavones; Isoproterenol; K Cl- Cotransporters; Marine Toxins; Oncorhynchus mykiss; Oxazoles; Phosphorylation; Potassium Chloride; Protein-Tyrosine Kinases; Staurosporine; Symporters; Tyrosine; Vanadates | 1996 |
CFTR chloride channel activation by genistein: the role of serine/threonine protein phosphatases.
Topics: 3T3 Cells; Animals; Colforsin; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Synergism; Genistein; Isoflavones; Isoquinolines; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase Inhibitors; Sulfonamides; Transfection | 1996 |
Calyculin A, a phosphoprotein phosphatase inhibitor, stimulates acid secretion in isolated gastric glands.
Topics: 4-Nitrophenylphosphatase; Animals; Cyclic AMP; Gastric Acid; Gastric Mucosa; In Vitro Techniques; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Rabbits; Stimulation, Chemical | 1996 |
Regulation of the mouse retinal taurine transporter (TAUT) by protein kinases in Xenopus oocytes.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Biological Transport; Carrier Proteins; Chlorides; Cyclic AMP-Dependent Protein Kinases; Diglycerides; Electrophysiology; Endocytosis; Enzyme Activation; Exocytosis; Female; Gene Expression Regulation; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Recombinant Proteins; Retina; Sodium; Xenopus laevis | 1996 |
Regulatory phosphorylation of the secretory Na-K-Cl cotransporter: modulation by cytoplasmic Cl.
Topics: Animals; Carrier Proteins; Chlorides; Cyclic AMP; Cytoplasm; Ions; Marine Toxins; Osmolar Concentration; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Potassium; Salt Gland; Sharks; Sodium-Potassium-Chloride Symporters; Time Factors | 1996 |
Permeability characteristics of erythrocyte membrane to okadaic acid and calyculin A.
Topics: Animals; Cell Membrane Permeability; Dose-Response Relationship, Drug; Erythrocyte Membrane; Marine Toxins; Okadaic Acid; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Rabbits; Time Factors | 1996 |
Effects of the phosphatase inhibitors calyculin A and okadaic acid on acetylcholine synthesis and content of rat hippocampal formation.
Topics: Acetylcholine; Animals; Choline; Choline O-Acetyltransferase; Hippocampus; In Vitro Techniques; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley | 1996 |
Regulation of alpha 4 integrin avidity in human B cells: requirement for dephosphorylation events for high avidity VCAM-1 binding.
Topics: B-Lymphocytes; Cell Adhesion; Cell Line; Ethers, Cyclic; Humans; Integrin alpha4beta1; Integrins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Receptors, Lymphocyte Homing; Signal Transduction; Vascular Cell Adhesion Molecule-1 | 1996 |
Evidence that the endogenous histone H1 phosphatase in HeLa mitotic chromosomes is protein phosphatase 1, not protein phosphatase 2A.
Topics: Cell Nucleus; Chromatin; Enzyme Inhibitors; HeLa Cells; Histones; Humans; Kinetin; Marine Toxins; Metaphase; Microcystins; Mitosis; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Purines; Staurosporine | 1996 |
Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood.
Topics: Actin Depolymerizing Factors; Androstadienes; Animals; Calcimycin; Calcium; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Ethers, Cyclic; Humans; Ionophores; Marine Toxins; Microfilament Proteins; N-Formylmethionine Leucyl-Phenylalanine; Nerve Tissue Proteins; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Swine; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Phosphatase inhibitors promote ICAM-1 and LFA-1 mediated homotypic aggregation of Jurkat and U937 cells.
Topics: Cell Aggregation; Cell Line; Enzyme Inhibitors; Ethers, Cyclic; Humans; Intercellular Adhesion Molecule-1; Lymphocyte Function-Associated Antigen-1; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases | 1996 |
Cytotoxic effects of anthrax lethal toxin on macrophage-like cell line J774A.1.
Topics: Animals; Apoptosis; Bacillus anthracis; Bacterial Toxins; Macrophages; Marine Toxins; Mice; Necrosis; Oxazoles; Phosphoprotein Phosphatases | 1996 |
Inhibitions of protein kinases and protein phosphatases have opposite effects on thyrotropin-stimulated cAMP accumulation in human thyroid cells.
Topics: Cells, Cultured; Cholera Toxin; Colforsin; Cyclic AMP; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Thyroid Gland; Thyrotropin; Time Factors | 1996 |
Dephosphorylation of the nucleocapsid protein of inoculum JHMV may be essential for initiating replication.
Topics: Animals; Bucladesine; Capsid; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Kinetics; L Cells; Marine Toxins; Mice; Murine hepatitis virus; Oligodendroglia; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Rats; Transfection; Viral Core Proteins; Virus Replication | 1995 |
Phosphorylation of 558T of moesin detected by site-specific antibodies in RAW264.7 macrophages.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Antigen-Antibody Complex; Blotting, Western; Cell Line; Cytochalasin B; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Macrophages; Marine Toxins; Microfilament Proteins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphothreonine; Proteins; Rabbits; Staurosporine; Threonine | 1996 |
Sperm motility development in the epididymis is associated with decreased glycogen synthase kinase-3 and protein phosphatase 1 activity.
Topics: Amino Acid Sequence; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Drug Stability; Enzyme Inhibitors; Epididymis; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hot Temperature; Male; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Sperm Motility; Spermatozoa | 1996 |
Primate sperm contain protein phosphatase 1, a biochemical mediator of motility.
Topics: Adult; Animals; Enzyme Inhibitors; Humans; Macaca mulatta; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylase a; Protein Phosphatase 1; Protein Phosphatase 2; Sperm Motility; Spermatozoa | 1996 |
Translocation of PKC, protein phosphatase inhibition and preconditioning of rabbit cardiomyocytes.
Topics: Adenosine; Animals; Cells, Cultured; Heart; Isoenzymes; Marine Toxins; Myocardial Ischemia; Myocardium; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1996 |
The rat osteocalcin fibroblast growth factor (FGF)-responsive element: an okadaic acid-sensitive, FGF-selective transcriptional response motif.
Topics: Animals; Cell Line; DNA; Enzyme Inhibitors; Fibroblast Growth Factor 2; Growth Substances; Marine Toxins; Mice; Okadaic Acid; Osteocalcin; Oxazoles; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Rats; Receptors, Fibroblast Growth Factor; Vanadates | 1996 |
Dephosphorylation of cofilin in parotid acinar cells.
Topics: Actin Depolymerizing Factors; Amylases; Animals; Calcimycin; Calcium; Carbachol; Cyclic AMP; Cyclosporine; Enzyme Inhibitors; Exocytosis; Ionophores; Isoproterenol; Marine Toxins; Microfilament Proteins; Nerve Tissue Proteins; Oxazoles; Parotid Gland; Phosphoprotein Phosphatases; Phosphorylation; Rats; Tacrolimus; Tetradecanoylphorbol Acetate | 1996 |
Role of phosphoprotein phosphatases in the corpus luteum: I identification and characterisation of serine/threonine phosphoprotein phosphatases in isolated rat luteal cells.
Topics: Animals; Antifungal Agents; Calcineurin; Calmodulin-Binding Proteins; Cantharidin; Cells, Cultured; Corpus Luteum; Dose-Response Relationship, Drug; Female; Marine Toxins; Microcystins; Molecular Weight; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Pyrans; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiro Compounds | 1996 |
Role of phosphoprotein phosphatases in the corpus luteum: II control of progesterone secretion by isolated rat luteal cells.
Topics: Animals; Bucladesine; Cantharidin; Cells, Cultured; Corpus Luteum; Cyclic AMP; Dose-Response Relationship, Drug; Female; Luteinizing Hormone; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Progesterone; Rats; Rats, Sprague-Dawley | 1996 |
Inhibition of p70/p85 S6 kinase activities in T cells by dexamethasone.
Topics: 1-Methyl-3-isobutylxanthine; Administration, Topical; Animals; Anti-Inflammatory Agents; Colforsin; Dexamethasone; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucocorticoids; Interleukin-2; Marine Toxins; Mice; Oxazoles; Phorbol Esters; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Polyenes; Protein Kinase C; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; RNA, Messenger; Sirolimus; T-Lymphocytes; Tacrolimus; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1996 |
Regulation of human basophil function by phosphatase inhibitors.
Topics: Basophils; Cells, Cultured; Enzyme Inhibitors; Histamine Release; Humans; Immunoglobulin E; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases | 1996 |
Evidence for a phorbol ester-insensitive phosphorylation step in capacitative calcium entry in rat thymic lymphocytes.
Topics: Animals; Biological Transport; Calcium; Enzyme Inhibitors; Ion Transport; Lymphocytes; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Wistar; Tetradecanoylphorbol Acetate; Thapsigargin; Thymus Gland | 1996 |
Ca(2+)-induced rebound potentiation of gamma-aminobutyric acid-mediated currents requires activation of Ca2+/calmodulin-dependent kinase II.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cerebellum; Drug Synergism; Enzyme Activation; Enzyme Inhibitors; gamma-Aminobutyric Acid; Imidazoles; In Vitro Techniques; Kinetics; Marine Toxins; Membrane Potentials; Nerve Fibers; Oxazoles; Purkinje Cells; Rats; Receptors, GABA-A; Signal Transduction; Staurosporine | 1996 |
Regulation of the initiation of coronavirus JHM infection in primary oligodendrocytes and L-2 fibroblasts.
Topics: Animals; Bucladesine; Carrier Proteins; Cell Differentiation; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Endosomes; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; L Cells; Marine Toxins; Mice; Molecular Weight; Murine hepatitis virus; Nucleocapsid; Okadaic Acid; Oligodendroglia; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Inbred WF; RNA, Viral; Telencephalon; Transfection; Virus Replication | 1996 |
Protein phosphatase activity is required for prothoracicotropic hormone-stimulated ecdysteroidogenesis in the prothoracic glands of the tobacco hornworm, Manduca sexta.
Topics: Animals; Ecdysteroids; Ganglia, Invertebrate; Insect Hormones; Manduca; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Ribosomal Protein S6; Ribosomal Proteins; Sirolimus; Steroids | 1996 |
Mechanism of swelling activation of K-Cl cotransport in inside-out vesicles of LK sheep erythrocyte membranes.
Topics: Adenosine Triphosphate; Animals; Body Fluids; Carrier Proteins; Chlorides; Erythrocyte Membrane; Ethylmaleimide; Homeostasis; K Cl- Cotransporters; Kinetics; Magnesium; Marine Toxins; Oxazoles; Phenotype; Phosphorylation; Potassium; Sheep; Staurosporine; Symporters; Time Factors | 1996 |
Regulation of natural killer cell-mediated cytotoxicity by serine/threonine phosphatases: identification of a calyculin A-sensitive serine/threonine kinase.
Topics: CD28 Antigens; Cell Line; Cytotoxicity, Immunologic; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Enzyme Stability; Ionophores; Killer Cells, Natural; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Subcellular Fractions; Tetradecanoylphorbol Acetate; Tyrosine | 1996 |
A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin.
Topics: Animals; Animals, Newborn; Bradykinin; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Ganglia, Spinal; Hot Temperature; Kinetics; Marine Toxins; Membrane Potentials; Neurons; Neurons, Afferent; Nociceptors; Oxazoles; Pain; Protein Kinase C; Protein Tyrosine Phosphatases; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Time Factors | 1996 |
Stimulation of Na(+)-K(+)-2Cl- cotransport in rat medullary thick ascending limb by dopamine.
Topics: Animals; Barium Compounds; Carrier Proteins; Chlorides; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Enzyme Inhibitors; Isomerism; Kidney Medulla; Loop of Henle; Marine Toxins; Oxazoles; Potassium Channel Blockers; Rats; Rats, Inbred WKY; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Thionucleotides | 1996 |
Inhibition of bradykinin-induced calcium increase by phosphatase inhibitors in neuroblastoma x glioma hybrid NG108-15 cells.
Topics: Animals; Bradykinin; Calcium; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glioma; Hybrid Cells; Marine Toxins; Mice; Neuroblastoma; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Signal Transduction; Thapsigargin; Type C Phospholipases | 1997 |
Modulation of GABAA receptor function by G protein-coupled 5-HT2C receptors.
Topics: Animals; Chelating Agents; Chloride Channels; Egtazic Acid; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Marine Toxins; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Receptors, GABA-A; Receptors, Serotonin; RNA, Messenger; Staurosporine; Transcription, Genetic; Xenopus laevis | 1996 |
The protein phosphatase inhibitors okadaic acid and calyculin A induce apoptosis in human osteoblastic cells.
Topics: Animals; Apoptosis; Cell Line; DNA Fragmentation; Enzyme Inhibitors; Humans; Marine Toxins; Mice; Okadaic Acid; Osteoblasts; Oxazoles; Phosphoprotein Phosphatases; Tumor Cells, Cultured | 1997 |
A molecular basis for different interactions of marine toxins with protein phosphatase-1. Molecular models for bound motuporin, microcystins, okadaic acid, and calyculin A.
Topics: Animals; Marine Toxins; Microcystins; Models, Molecular; Monte Carlo Method; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Phosphatase 1; Toxins, Biological | 1997 |
Interphase-like chromatin configuration induced by cycloheximide in maturing pig oocytes: effects of protein phosphatase inhibitors.
Topics: Animals; Chromatin; Cycloheximide; Enzyme Inhibitors; Female; Interphase; Kinetics; Marine Toxins; Microtubules; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Protein Synthesis Inhibitors; Swine; Tubulin | 1996 |
The serine/threonine phosphatase inhibitor calyculin A induces rapid degradation of IkappaBbeta. Requirement of both the N- and C-terminal sequences.
Topics: Animals; Cell Nucleus; DNA; DNA-Binding Proteins; Drug Synergism; Enzyme Inhibitors; Humans; I-kappa B Proteins; Jurkat Cells; Marine Toxins; Mice; NF-kappa B; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 1997 |
Modulation of CFTR chloride channels by calyculin A and genistein.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Cell Line; Chloride Channels; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Drug Synergism; Enzyme Inhibitors; Genistein; Hydrolysis; Insecta; Ion Channel Gating; Isoflavones; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Protein-Tyrosine Kinases | 1997 |
Combinatorial synthesis and biological evaluation of library of small-molecule Ser/Thr-protein phosphatase inhibitors.
Topics: Breast Neoplasms; Cell Cycle; Cell Division; Drug Design; Enzyme Inhibitors; Humans; Magnetic Resonance Spectroscopy; Marine Toxins; Mass Spectrometry; Oxazoles; Phosphoprotein Phosphatases; Serine; Threonine; Tumor Cells, Cultured | 1997 |
Hyperphosphorylation of beta-catenin on serine-threonine residues and loss of cell-cell contacts induced by calyculin A and okadaic acid in human epidermal cells.
Topics: Apoptosis; beta Catenin; Calcium; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Epidermal Cells; Epidermis; Humans; Intercellular Junctions; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphotyrosine; Protein Kinase Inhibitors; Protein Kinases; Protein Phosphatase 1; Trans-Activators | 1997 |
Characterization of a novel filament system in goldfish xanthophores.
Topics: Actin Cytoskeleton; Actins; Animals; Antibodies, Monoclonal; Chromatophores; Cytoskeletal Proteins; Cytoskeleton; Fluorescent Antibody Technique, Indirect; Goldfish; Immunoblotting; Intermediate Filaments; Marine Toxins; Microscopy, Immunoelectron; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation | 1997 |
Regulation of the renal Na-HCO3 cotransporter: VII. Mechanism of the cholinergic stimulation.
Topics: Animals; Bicarbonates; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Carrier Proteins; Chelating Agents; Cholinergic Agents; Egtazic Acid; Enzyme Inhibitors; Estrenes; Ion Transport; Kidney Tubules, Proximal; Marine Toxins; Naphthalenes; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Pyrrolidinones; Rabbits; Sodium; Sodium-Bicarbonate Symporters; Sulfonamides; Type C Phospholipases | 1997 |
Regulation of IkappaBbeta degradation. Similarities to and differences from IkappaBalpha.
Topics: Animals; Cell Line; DNA-Binding Proteins; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; I-kappa B Proteins; Lipopolysaccharides; Lysine; Marine Toxins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Serine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1997 |
Effect of protein phosphatase inhibitors on cleavage furrow formation in newt eggs: inhibition of normal furrow formation and concomitant induction of furrow-like dents.
Topics: Animals; Antifungal Agents; Cleavage Stage, Ovum; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pyrans; Salamandridae; Spiro Compounds | 1997 |
Cell cycle-dependent phosphorylation of mammalian protein phosphatase 1 by cdc2 kinase.
Topics: 3T3 Cells; Animals; Antibodies; CDC2 Protein Kinase; Cell Cycle; Cell Line; Enzyme Inhibitors; Fluorescent Antibody Technique, Indirect; Kinetin; Mammals; Marine Toxins; Mice; Mitosis; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Purines; Recombinant Proteins; Threonine; Transfection | 1997 |
Urea inhibits Na-K-2Cl cotransport in medullary thick ascending limb cells.
Topics: Animals; Binding Sites; Bumetanide; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Kidney Medulla; Loop of Henle; Marine Toxins; Mice; Okadaic Acid; Osmolar Concentration; Oxazoles; Potassium; Sodium-Potassium-Chloride Symporters; Urea | 1997 |
Thrombin inhibits myosin light chain dephosphorylation in endothelial cells.
Topics: Calcium; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Humans; Marine Toxins; Myosin Light Chains; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Thrombin | 1997 |
Detection of radiation-induced chromosome aberrations using fluorescence in situ hybridization in drug-induced premature chromosome condensations of tumour cell lines with different radiosensitivities.
Topics: Animals; Cell Cycle; Chromosome Aberrations; Chromosomes; Enzyme Inhibitors; Humans; In Situ Hybridization, Fluorescence; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tumor Cells, Cultured | 1997 |
Low concentrations of the phosphatase inhibitor okadaic acid stop tumor cell locomotion.
Topics: Actins; Animals; Carcinoma 256, Walker; Cell Movement; Cell Size; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Immunoblotting; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Staining and Labeling; Tumor Cells, Cultured; Vimentin | 1997 |
Defining the volume dependence of multiple K flux pathways of trout red blood cells.
Topics: Adrenergic beta-Agonists; Ammonium Chloride; Animals; Enzyme Inhibitors; Erythrocytes; Isoproterenol; Marine Toxins; Oncorhynchus mykiss; Osmosis; Oxazoles; Phosphoprotein Phosphatases; Potassium | 1997 |
Differential inhibition and posttranslational modification of protein phosphatase 1 and 2A in MCF7 cells treated with calyculin-A, okadaic acid, and tautomycin.
Topics: Antifungal Agents; Blotting, Western; Cell Membrane Permeability; Cell-Free System; Down-Regulation; Enzyme Inhibitors; Humans; Intermediate Filaments; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Binding; Protein Phosphatase 1; Protein Processing, Post-Translational; Pyrans; Solubility; Spiro Compounds; Tumor Cells, Cultured | 1997 |
Differential control of the hyperpolarization-activated current (i(f)) by cAMP gating and phosphatase inhibition in rabbit sino-atrial node myocytes.
Topics: Acetylcholine; Adrenergic beta-Agonists; Animals; Biological Clocks; Cyclic AMP; Electrophysiology; Enzyme Inhibitors; In Vitro Techniques; Ion Channel Gating; Isoproterenol; Marine Toxins; Membrane Potentials; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Rabbits; Sinoatrial Node | 1997 |
Modulation of serotonin transporter activity by a protein kinase C activator and an inhibitor of type 1 and 2A serine/threonine phosphatases.
Topics: Adrenergic Uptake Inhibitors; Animals; Carcinogens; Carrier Proteins; Choriocarcinoma; COS Cells; Humans; Imipramine; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Rats; Serotonin; Serotonin Plasma Membrane Transport Proteins; Tetradecanoylphorbol Acetate; Time Factors; Transfection; Tritium; Tumor Cells, Cultured | 1997 |
A method for detecting sister chromatid exchanges using prematurely condensed chromosomes and immunogold-silver staining.
Topics: Bromodeoxyuridine; Chromosomes, Human; Humans; Immunohistochemistry; Marine Toxins; Mitomycin; Mutagens; Oxazoles; Sister Chromatid Exchange; Staining and Labeling | 1997 |
Inhibition of serine-threonine protein phosphatases decreases barrier function of rat pulmonary microvascular endothelial cells.
Topics: Animals; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Intercellular Junctions; Lung; Marine Toxins; Microcirculation; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats | 1997 |
Activation of the avian erythrocyte Na-K-Cl cotransport protein by cell shrinkage, cAMP, fluoride, and calyculin-A involves phosphorylation at common sites.
Topics: Animals; Carrier Proteins; Cell Size; Cyclic AMP; Ducks; Erythrocytes; Female; Kinetics; Marine Toxins; Oxazoles; Peptide Mapping; Phosphopeptides; Phosphorus Radioisotopes; Phosphorylation; Sodium-Potassium-Chloride Symporters | 1997 |
Effect of the protein phosphatase inhibitors, okadaic acid and calyculin A, on dexamethasone-mediated inhibition of neutrophil apoptosis.
Topics: Apoptosis; Cells, Cultured; Dexamethasone; Enzyme Inhibitors; Humans; Kinetics; Marine Toxins; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 1997 |
Genistein directly induces cardiac CFTR chloride current by a tyrosine kinase-independent and protein kinase A-independent pathway in guinea pig ventricular myocytes.
Topics: Adrenergic beta-Agonists; Animals; Cells, Cultured; Chloride Channels; Chlorides; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Female; Genistein; Guinea Pigs; Heart Ventricles; Isoflavones; Isoproterenol; Isoquinolines; Male; Marine Toxins; Myocardium; Oxazoles; Patch-Clamp Techniques; Protein-Tyrosine Kinases; Sulfonamides | 1997 |
Palytoxin-induced increase in endothelial Ca2+ concentration in the rabbit aortic valve.
Topics: Acrylamides; Adenosine Triphosphate; Animals; Aortic Valve; Calcium; Cnidarian Venoms; Colforsin; Endothelium, Vascular; In Vitro Techniques; Lanthanum; Marine Toxins; Microscopy, Confocal; Ouabain; Oxazoles; Potassium; Rabbits; Sodium; Thapsigargin; Vasoconstrictor Agents | 1997 |
Selective destruction of stable microtubules and axons by inhibitors of protein serine/threonine phosphatases in cultured human neurons.
Topics: Axons; Enzyme Inhibitors; Humans; Marine Toxins; Microtubules; Neurons; Okadaic Acid; Oxazoles; Serine; Threonine; Tumor Cells, Cultured | 1997 |
Involvement of calyculin A inhibitable protein phosphatases in the cyclic AMP signal transduction pathway of mouse corticotroph tumour (AtT20) cells.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Adenylate Cyclase Toxin; Adrenocorticotropic Hormone; Animals; Cholera Toxin; Colforsin; Cyclic AMP; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Pertussis Toxin; Phosphoprotein Phosphatases; Pituitary Neoplasms; Signal Transduction; Tumor Cells, Cultured; Virulence Factors, Bordetella | 1997 |
Inhibitors of ser/thr phosphatases 1 and 2A induce apoptosis in pituitary GH3 cells.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; DNA Fragmentation; Enzyme Inhibitors; In Vitro Techniques; L-Lactate Dehydrogenase; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pituitary Gland; Plasmids; Rats; Transfection | 1997 |
Inhibition of B2 receptor internalization delays its dephosphorylation.
Topics: Autoradiography; Bradykinin; Bradykinin Receptor Antagonists; Cantharidin; Cell Line; Concanavalin A; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fibroblasts; Humans; Irritants; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Radioligand Assay; Receptor, Bradykinin B2; Receptors, Bradykinin; Skin; Sucrose | 1997 |
Low-frequency stimulation of afferent Adelta-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat.
Topics: 2-Amino-5-phosphonovalerate; Animals; Calcium; Chelating Agents; Egtazic Acid; Electric Stimulation; Electrophysiology; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Long-Term Potentiation; Male; Marine Toxins; Nerve Fibers; Neurons, Afferent; Oxazoles; Pain; Phosphoric Monoester Hydrolases; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Substantia Gelatinosa; Synaptic Transmission | 1997 |
Inhibitors of phosphoprotein phosphatases 1 and 2A cause activation of a 53 kDa protein kinase accompanying the apoptotic response of breast cancer cells.
Topics: Calcium-Calmodulin-Dependent Protein Kinases; Cycloheximide; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Myelin Basic Protein; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Phosphatase 1; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Tumor Cells, Cultured | 1997 |
Effects of calyculin A and FK506 on the O2- generation of rat peritoneal macrophages.
Topics: Animals; Macrophages, Peritoneal; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Superoxides; Tacrolimus | 1996 |
Specificity of the test based on modification of cell morphology for detection of lipophilic inhibitors of protein phosphatases.
Topics: Animals; Cell Line; Chromatography, High Pressure Liquid; Enzyme Inhibitors; Lipids; Liver; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Sensitivity and Specificity; Solubility | 1997 |
Control of PHAS-I phosphorylation in 3T3-L1 adipocytes: effects of inhibiting protein phosphatases and the p70S6K signalling pathway.
Topics: 3T3 Cells; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Carrier Proteins; Cell Cycle Proteins; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Eukaryotic Initiation Factors; Fibroblasts; Immune Sera; Immunoblotting; Insulin; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Peptide Initiation Factors; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Polyenes; Rabbits; Repressor Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Wortmannin | 1997 |
Cyanide suppression of inwardly rectifying K+ channels in guinea pig chromaffin cells involves dephosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Adrenal Medulla; Animals; Cells, Cultured; Chromaffin Cells; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guinea Pigs; Kinetics; Marine Toxins; Membrane Potentials; Oxazoles; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Potassium Channels; Potassium Channels, Inwardly Rectifying; Ribonucleotides; Sodium Cyanide; Uridine Triphosphate | 1997 |
Colchicine activates actin polymerization by microtubule depolymerization.
Topics: 3T3 Cells; Actins; Animals; Biopolymers; Cell Line; Colchicine; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mice; Microtubules; Okadaic Acid; Oxazoles; Phospholipase D; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rats; Serine; Threonine; Type C Phospholipases | 1997 |
Spontaneous Mn2+ entry is specifically inhibited by calyculin A in human leukemic HL-60 cells.
Topics: Calcium; Colforsin; Depression, Chemical; Dimethyl Sulfoxide; Enzyme Inhibitors; HL-60 Cells; Humans; Manganese; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tetradecanoylphorbol Acetate | 1997 |
Unopposed phosphatase action initiates ezrin dysfunction: a potential mechanism for anoxic injury.
Topics: Alkaloids; Animals; Benzophenanthridines; Cytoskeletal Proteins; Enzyme Inhibitors; Female; Hypoxia; Kidney Tubules, Proximal; Marine Toxins; Oxazoles; Phenanthridines; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphotransferases; Protein Kinase C; Rabbits; Reference Values | 1997 |
Apoptosis induction by inhibitors of Ser/Thr phosphatases 1 and 2A is associated with transglutaminase activation in two different human epithelial tumour lines.
Topics: Apoptosis; Cell Membrane; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Activation; Epithelium; HeLa Cells; Humans; L-Lactate Dehydrogenase; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Time Factors; Transglutaminases; Tumor Cells, Cultured | 1997 |
The binding mode of calyculin A to protein phosphatase-1. A novel spiroketal vector model.
Topics: Binding Sites; Computer Simulation; Databases, Factual; Dopamine and cAMP-Regulated Phosphoprotein 32; Marine Toxins; Models, Molecular; Nerve Tissue Proteins; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Protein Phosphatase 1; Software; Stereoisomerism | 1997 |
Phosphatase activity regulates superoxide anion generation and intracellular signaling in human neutrophils.
Topics: Adult; Humans; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxazoles; Phosphatidic Acids; Phospholipase D; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Staurosporine; Superoxides; Tetradecanoylphorbol Acetate | 1997 |
The effects of sodium butyrate on transcription are mediated through activation of a protein phosphatase.
Topics: Butyrates; Butyric Acid; Enzyme Activation; Enzyme Inhibitors; Genes, myc; Histones; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Processing, Post-Translational; RNA, Messenger; Transcription, Genetic; Tumor Cells, Cultured | 1997 |
Effects of long-term treatment with desipramine on microtubule proteins in rat cerebral cortex.
Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents, Tricyclic; Cerebral Cortex; Desipramine; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Male; Marine Toxins; Microtubule-Associated Proteins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Rats; Rats, Wistar; Serine | 1997 |
Oxidant stress-induced transendothelial migration of monocytes is linked to phosphorylation of PECAM-1.
Topics: Adenine; Antibodies, Monoclonal; Antioxidants; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Enzyme Inhibitors; HL-60 Cells; Humans; Indoles; Kainic Acid; Kinetics; Maleimides; Marine Toxins; Monocytes; Oxazoles; Oxidative Stress; Peroxides; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Probucol; Reactive Oxygen Species; Signal Transduction; tert-Butylhydroperoxide; Thiobarbituric Acid Reactive Substances; Umbilical Veins; Vitamin E | 1997 |
Troponin I phosphorylation in spontaneously hypertensive rat heart: effect of beta-adrenergic stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; 8-Bromo Cyclic Adenosine Monophosphate; Adrenergic beta-Agonists; Animals; Calcium; Calcium-Binding Proteins; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electric Stimulation; Enzyme Inhibitors; Heart; Heart Ventricles; Hypertension; Isoproterenol; Marine Toxins; Myocardial Contraction; Myocardium; Myosin Light Chains; Norepinephrine; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prazosin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Troponin I | 1997 |
The possible role of protein phosphatase 2A in the sodium sensitivity of the receptor binding of opiate antagonists naloxone and naltrindole.
Topics: Animals; Corpus Striatum; Enzyme Activation; Enzyme Inhibitors; Male; Marine Toxins; Naloxone; Naltrexone; Narcotic Antagonists; Oxazoles; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylase a; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, Opioid; Sensitivity and Specificity; Sodium Chloride; Substrate Specificity; Tritium | 1997 |
Cofilin undergoes rapid dephosphorylation in stimulated neutrophils and translocates to ruffled membranes enriched in products of the NADPH oxidase complex. Evidence for a novel cycle of phosphorylation and dephosphorylation.
Topics: Actin Depolymerizing Factors; Actins; Amino Acid Sequence; Animals; Calcimycin; Cell Membrane; Diglycerides; Diterpenes; Guinea Pigs; Humans; Hydrogen Peroxide; Immunoblotting; Marine Toxins; Microfilament Proteins; Molecular Sequence Data; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Oxides; Phosphorylation; Staurosporine; Terpenes; Tetradecanoylphorbol Acetate | 1997 |
Impairment of cation transport in A549 cells and rat alveolar epithelial cells by hypoxia.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Amiloride; Animals; Carrier Proteins; Cations, Monovalent; Cell Hypoxia; Cell Membrane; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Humans; Kinetics; Lung Neoplasms; Marine Toxins; Oxazoles; Potassium; Pulmonary Alveoli; Rats; Sodium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Tumor Cells, Cultured | 1997 |
Modulation of rod photoreceptor cyclic nucleotide-gated channels by tyrosine phosphorylation.
Topics: Adenosine Triphosphate; Animals; Cyclic GMP; Enzyme Inhibitors; Eye Proteins; Hydroquinones; Ion Channel Gating; Marine Toxins; Microcystins; Okadaic Acid; Oocytes; Oxazoles; Patch-Clamp Techniques; Peptides, Cyclic; Phenols; Phosphorylation; Protein Processing, Post-Translational; Protein Tyrosine Phosphatases; Rod Cell Outer Segment; Staurosporine; Vanadates; Xenopus laevis | 1997 |
Regulation of cellular phosphorylation of hyaluronan binding protein and its role in the formation of second messenger.
Topics: Animals; Cell Line; Cell Line, Transformed; Cell Membrane; Enzyme Inhibitors; Hyaluronan Receptors; Hyaluronic Acid; Immunoblotting; Inositol 1,4,5-Trisphosphate; Isoenzymes; Kinetics; Marine Toxins; Oxazoles; Phospholipase C gamma; Phosphorylation; Polyomavirus; Protein Kinase Inhibitors; Protein Kinases; Rats; Second Messenger Systems; Skin; Staurosporine; Tetradecanoylphorbol Acetate; Type C Phospholipases | 1997 |
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
Topics: Animals; Binding Sites; Enzyme Inhibitors; Humans; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Intracellular Signaling Peptides and Proteins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rats; Receptor, Insulin; Sphingomyelin Phosphodiesterase; Tumor Necrosis Factor-alpha; Tyrosine | 1997 |
Phosphoserine/threonine phosphatases in the rat adrenal cortex: a role in the control of steroidogenesis?
Topics: Adrenal Cortex; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Aldosterone; Animals; Antifungal Agents; Bucladesine; Cells, Cultured; Colforsin; Corticosterone; Enzyme Inhibitors; Immunoblotting; Male; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoric Monoester Hydrolases; Phosphothreonine; Pyrans; Rats; Rats, Sprague-Dawley; Signal Transduction; Spiro Compounds; Stimulation, Chemical | 1997 |
A model for binding of structurally diverse natural product inhibitors of protein phosphatases PP1 and PP2A.
Topics: Antifungal Agents; Crystallography, X-Ray; Enzyme Inhibitors; Marine Toxins; Microcystins; Models, Molecular; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Binding; Protein Conformation; Pyrans; Signal Transduction; Spiro Compounds; Stereoisomerism; Structure-Activity Relationship; Toxins, Biological | 1997 |
Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase.
Topics: Animals; Cell Line; COUP Transcription Factor II; COUP Transcription Factors; DNA; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression Regulation; Hedgehog Proteins; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Promoter Regions, Genetic; Proteins; Receptors, Steroid; Signal Transduction; Trans-Activators; Transcription Factors | 1997 |
A novel assay for evaluating glycogenolysis in rat adipocytes and the inability of insulin to antagonize glycogenolysis in this cell type.
Topics: 1-Methyl-3-isobutylxanthine; Adipocytes; Adrenocorticotropic Hormone; Animals; Catecholamines; Cholera Toxin; Cyclic AMP; Enzyme Inhibitors; Glucose; Glycogen; Insulin; Isoproterenol; Lipolysis; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Rats, Wistar; Vanadates | 1997 |
Inhibition of the iron-induced ZmFer1 maize ferritin gene expression by antioxidants and serine/threonine phosphatase inhibitors.
Topics: Abscisic Acid; Antioxidants; Enzyme Inhibitors; Ferritins; Gene Expression Regulation, Plant; Iron; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Transcription, Genetic; Zea mays | 1997 |
Effect of recombinant interleukin-6 and thrombopoietin on isolated guinea pig bone marrow megakaryocyte protein phosphorylation and proplatelet formation.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Blood Platelets; Blood Proteins; Bone Marrow Cells; Cell Division; Cells, Cultured; Enzyme Inhibitors; Genistein; Guinea Pigs; Interleukin-1; Interleukin-3; Interleukin-6; Kinetics; Male; Marine Toxins; Megakaryocytes; Okadaic Acid; Oxazoles; Phosphates; Phosphorylation; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Recombinant Proteins; Thrombopoietin; Thymidine | 1997 |
Protein phosphatase 1 and 2A inhibitors activate acyl-CoA:cholesterol acyltransferase and cholesterol ester formation in isolated rat hepatocytes.
Topics: Animals; Anticholesteremic Agents; Cantharidin; Cells, Cultured; Cholesterol Esters; Enzyme Activation; Enzyme Inhibitors; Female; Liver; Lovastatin; Marine Toxins; Microsomes, Liver; Okadaic Acid; Oleic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; Sterol O-Acyltransferase; Time Factors | 1997 |
The inhibitory effect of beta-stimulation on the Na/K pump current in guinea pig ventricular myocytes is mediated by a cAMP-dependent PKA pathway.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Male; Marine Toxins; Membrane Potentials; Myocardium; Oxazoles; Patch-Clamp Techniques; Phosphorylation; Sodium-Potassium-Exchanging ATPase | 1998 |
C-type natriuretic peptide inhibits rat mesangial cell proliferation by a phosphorylation-dependent mechanism.
Topics: Angiotensin II; Animals; Atrial Natriuretic Factor; Cell Count; Cell Division; Cells, Cultured; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Enzyme Inhibitors; Glomerular Mesangium; Interleukin-1; Interleukin-6; Marine Toxins; Natriuretic Peptide, C-Type; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Proteins; Rats; Thymidine | 1998 |
Okadaic acid-induced decrease in the magnitude and efficacy of the Ca2+ signal in pancreatic beta cells and inhibition of insulin secretion.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Calcium Channels; Cytoplasm; Energy Metabolism; Enzyme Inhibitors; Ethers, Cyclic; Exocytosis; Female; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 1998 |
GTP-binding protein gamma12 subunit phosphorylation by protein kinase C--identification of the phosphorylation site and factors involved in cultured cells and rat tissues in vivo.
Topics: 3T3 Cells; Animals; Antibodies; Binding Sites; GTP-Binding Proteins; Lysophospholipids; Marine Toxins; Mice; Oxazoles; Peptide Fragments; Pertussis Toxin; Phosphorylation; Platelet-Derived Growth Factor; Protein Kinase C; Rats; Rats, Wistar; Serine; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1998 |
Protein phosphatase inhibitors calyculin A and fostriecin protect rabbit cardiomyocytes in late ischemia.
Topics: Adenosine Triphosphate; Alkenes; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ischemic Preconditioning, Myocardial; Marine Toxins; Mitogen-Activated Protein Kinases; Myocardial Ischemia; Myocardium; Naphthalenes; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Kinase C; Pyrones; Rabbits | 1998 |
Modulation of Sp1 phosphorylation by human immunodeficiency virus type 1 Tat.
Topics: Androstadienes; Binding Sites; Cell Nucleus; DNA-Activated Protein Kinase; DNA-Binding Proteins; Enzyme Inhibitors; Gene Expression; Gene Products, tat; HeLa Cells; HIV Long Terminal Repeat; HIV-1; Humans; Jurkat Cells; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; Serine; Sp1 Transcription Factor; tat Gene Products, Human Immunodeficiency Virus; Transcription, Genetic; Wortmannin | 1998 |
Mastoparan induces an increase in cytosolic calcium ion concentration and subsequent activation of protein kinases in tobacco suspension culture cells.
Topics: Aequorin; Apoproteins; Calcium; Calcium Channel Blockers; Cells, Cultured; Cytosol; Enzyme Activation; Enzyme Inhibitors; Gallic Acid; Hydrogen Peroxide; Intercellular Signaling Peptides and Proteins; Marine Toxins; Neomycin; Nicotiana; Oxazoles; Oxidation-Reduction; Peptides; Phosphoprotein Phosphatases; Plants, Genetically Modified; Plants, Toxic; Protein Kinase Inhibitors; Protein Kinases; Recombinant Proteins; Signal Transduction; Staurosporine; Wasp Venoms | 1998 |
Transient exposure of rhesus macaque oocytes to calyculin-A and okadaic acid stimulates germinal vesicle breakdown permitting subsequent development and fertilization.
Topics: Animals; Cytoplasm; Enzyme Inhibitors; Female; Fertilization in Vitro; Immunohistochemistry; Macaca mulatta; Male; Marine Toxins; Meiosis; Okadaic Acid; Oocytes; Ovarian Follicle; Oxazoles; Phosphoprotein Phosphatases | 1998 |
The mutant plasmacytoma cell line S107 allows the identification of distinct pathways leading to NF-kappaB activation.
Topics: Animals; DNA; DNA-Binding Proteins; Endoplasmic Reticulum; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; I-kappa B Proteins; MAP Kinase Kinase Kinase 1; Marine Toxins; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Plasmacytoma; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Pyrrolidines; Signal Transduction; Thiocarbamates; Transcription Factor RelB; Transcription Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1998 |
Adherent neutrophils activate endothelial myosin light chain kinase: role in transendothelial migration.
Topics: Alkaloids; Animals; Azepines; Capillary Permeability; Carbazoles; Cattle; Cell Adhesion; Cell Movement; Cells, Cultured; Chemotactic Factors; Cyclic AMP-Dependent Protein Kinases; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Indoles; Inflammation; Leukotriene B4; Marine Toxins; Muscle, Smooth, Vascular; Myosin-Light-Chain Kinase; Naphthalenes; Neutrophils; Oxazoles; Phosphorylation; Pulmonary Artery | 1998 |
A volume-sensitive protein kinase regulates the Na-K-2Cl cotransporter in duck red blood cells.
Topics: Animals; Carrier Proteins; Ducks; Enzyme Inhibitors; Erythrocytes; Ethylmaleimide; Female; Kinetics; Marine Toxins; Oxazoles; Phosphorylation; Protein Kinases; Sodium-Potassium-Chloride Symporters; Staurosporine | 1998 |
Inhibition of p130cas tyrosine phosphorylation by calyculin A.
Topics: Cell Aggregation; Crk-Associated Substrate Protein; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Kinases; Protein Tyrosine Phosphatases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-crk; Protozoan Proteins; Retinoblastoma-Like Protein p130; src-Family Kinases; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1998 |
Differential regulation of single CFTR channels by PP2C, PP2A, and other phosphatases.
Topics: Animals; Animals, Newborn; Cell Line; CHO Cells; Cricetinae; Cystic Fibrosis Transmembrane Conductance Regulator; Electrophysiology; Enzyme Inhibitors; Humans; Ion Channels; Kidney; Magnesium; Marine Toxins; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Protein Phosphatase 2; Protein Phosphatase 2C; Saccharomyces cerevisiae Proteins | 1998 |
Mutual relation between the cell-cycle progression and prespore differentiation in Dictyostelium development.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Dictyostelium; Enzyme Inhibitors; Marine Toxins; Microtubules; Nocodazole; Oxazoles; Spores | 1998 |
A protein phosphatase is involved in the inhibition of histone deacetylation by sodium butyrate.
Topics: Acetyltransferases; Butyrates; Butyric Acid; Histone Acetyltransferases; Histone Deacetylases; Histones; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Saccharomyces cerevisiae Proteins | 1998 |
Regulation of renin secretion through reversible phosphorylation of myosin by myosin light chain kinase and protein phosphatase type 1.
Topics: Animals; Azepines; Calcium; Enzyme Inhibitors; Female; Male; Marine Toxins; Myosin-Light-Chain Kinase; Myosins; Naphthalenes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Rats; Rats, Sprague-Dawley; Renin | 1998 |
Calyculin A modulates the kinetic constants for the Na+-coupled taurine transport in Ehrlich ascites tumour cells.
Topics: Animals; Biological Transport; Carbon Radioisotopes; Carcinogens; Carcinoma, Ehrlich Tumor; Carrier Proteins; Cell Size; Female; Kinetics; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Mice; Oxazoles; Phosphoprotein Phosphatases; Sodium; Taurine; Tumor Cells, Cultured | 1998 |
Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.
Topics: 3T3 Cells; Adenosine Triphosphate; Animals; Casein Kinases; Cells, Cultured; Enzyme Inhibitors; Escherichia coli; HeLa Cells; Homeostasis; Humans; Isoenzymes; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Rats | 1998 |
Modulation of the growth of Plasmodium falciparum in vitro by protein serine/threonine phosphatase inhibitors.
Topics: Animals; Cell Division; Culture Media; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Plasmodium falciparum; Protein Phosphatase 1; Protein Phosphatase 2; Time Factors | 1998 |
Modulation of glutamate sensitivities by inhibitors of a protein kinase and a protein phosphatase in cultured rat Purkinje cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutamic Acid; Iontophoresis; Marine Toxins; Nerve Tissue Proteins; Oxazoles; Protein Tyrosine Phosphatases; Purkinje Cells; Rats; Receptors, AMPA; Sulfonamides | 1998 |
Inhibition of a K+ conductance by the phosphatase inhibitor calyculin A in rat distal colon.
Topics: Animals; Colon; Cyclic AMP; Electric Conductivity; Enzyme Inhibitors; Female; Genistein; In Vitro Techniques; Intestinal Mucosa; Ion Transport; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Potassium Channel Blockers; Potassium Channels; Protein-Tyrosine Kinases; Rats; Rats, Wistar | 1998 |
Differential oxygen sensitivity of the K+-Cl- cotransporter in normal and sickle human red blood cells.
Topics: Anemia, Sickle Cell; Bumetanide; Carboxylic Acids; Carrier Proteins; Chlorides; Egtazic Acid; Enzyme Inhibitors; Erythrocytes; Hemoglobin A; Hemoglobin, Sickle; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Indenes; Magnesium; Marine Toxins; Ouabain; Oxazoles; Oxygen; Potassium; Reference Values; Sodium-Potassium-Chloride Symporters; Urea | 1998 |
Na+-K+-2Cl- cotransport in Ehrlich cells: regulation by protein phosphatases and kinases.
Topics: Animals; Azepines; Bradykinin; Carbazoles; Carcinoma, Ehrlich Tumor; Carrier Proteins; Chlorides; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Homeostasis; Hypertonic Solutions; Indoles; Isoquinolines; Kinetics; Marine Toxins; Mice; Myosin-Light-Chain Kinase; Naphthalenes; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Potassium; Protein Kinases; Pyrroles; Sodium-Potassium-Chloride Symporters; Sulfonamides; Tumor Cells, Cultured | 1998 |
Sensitive detection of apoptogenic toxins in suspension cultures of rat and salmon hepatocytes.
Topics: Animals; Apoptosis; Cell Aggregation; Cells, Cultured; Eukaryota; Liver; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Pyrans; Rats | 1998 |
Taurine might be acting as a trophic factor in the retina by modulating phosphorylation of cellular proteins.
Topics: Animals; Antineoplastic Agents, Hormonal; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Eye Proteins; Goldfish; Growth Substances; Indoles; Lactams; Marine Toxins; Okadaic Acid; Optic Nerve; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Retina; Sulfonamides; Tamoxifen; Taurine; Tetradecanoylphorbol Acetate | 1998 |
Endotoxin-induced migration of monocytes and PECAM-1 phosphorylation are abrogated by PAF receptor antagonists.
Topics: Azepines; Cell Differentiation; Cells, Cultured; Chemotaxis, Leukocyte; Endothelium, Vascular; Endotoxins; Escherichia coli; Gene Expression Regulation; HL-60 Cells; Humans; Indoles; Lipopolysaccharide Receptors; Lipopolysaccharides; Maleimides; Marine Toxins; Monocytes; Oxazoles; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Pyridinium Compounds; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Transcription, Genetic; Triazoles; Umbilical Veins | 1998 |
Alterations in the balance of protein kinase/phosphatase activities parallel reduced synaptic strength during aging.
Topics: Aging; Animals; Brain Chemistry; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Hippocampus; Male; Marine Toxins; Microcystins; Organ Culture Techniques; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinases; Protein Phosphatase 1; Rats; Rats, Inbred F344; Synapses | 1998 |
Cystic fibrosis transmembrane conductance regulator activation by cAMP-independent mechanisms.
Topics: 1-Methyl-3-isobutylxanthine; 3T3 Cells; Animals; Benzimidazoles; Chlorophenols; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Cystic Fibrosis Transmembrane Conductance Regulator; Enzyme Inhibitors; Genistein; Humans; Kinetics; Marine Toxins; Mice; Oxazoles; Phosphopeptides; Phosphorylation; Recombinant Proteins; Sequence Deletion; Transfection; Xanthines | 1998 |
Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses.
Topics: Animals; Calcium; Cattle; Cells, Cultured; Endothelium, Vascular; Enzyme Inhibitors; Ionomycin; Kinetics; Marine Toxins; Myosin Light Chains; Myosin-Light-Chain Kinase; Nitriles; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pulmonary Artery; Pyrethrins; Thrombin | 1998 |
Cytokine induction of NO synthase II in human DLD-1 cells: roles of the JAK-STAT, AP-1 and NF-kappaB-signaling pathways.
Topics: Cytokines; DNA; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Interferon-gamma; Interferon-Stimulated Gene Factor 3; Interleukin-1; Janus Kinase 2; Marine Toxins; NF-kappa B; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Promoter Regions, Genetic; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Transcription Factors; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Tyrphostins | 1998 |
Enhancement of glycine receptor function by ethanol: role of phosphorylation.
Topics: Animals; Cloning, Molecular; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Female; Glycine; Glycine Agents; Halothane; Humans; Indoles; Maleimides; Marine Toxins; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Propofol; Protein Kinase C; Receptors, Glycine; Staurosporine; Strychnine; Xenopus laevis | 1998 |
Protein phosphatase 2A is involved in hyphal growth of Neurospora crassa.
Topics: Antisense Elements (Genetics); Blotting, Northern; Blotting, Southern; Cantharidin; Catalytic Domain; Cell Division; Cycloheximide; Enzyme Inhibitors; Isocitrate Lyase; Marine Toxins; Mutagenesis, Insertional; Neurospora crassa; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Protein Phosphatase 2; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Temperature | 1998 |
A simple method for simultaneous interphase-metaphase chromosome analysis in biodosimetry.
Topics: Cell Cycle; Chromosome Aberrations; Chromosomes; Humans; Interphase; Lymphocytes; Marine Toxins; Metaphase; Microscopy, Fluorescence; Mitosis; Oxazoles; Radiometry; X-Rays | 1998 |
Relationship between biochemical and functional effects of protein phosphatase 1 inhibitors in rabbit cardiac skinned fibers.
Topics: Animals; Antifungal Agents; Caffeine; Calcium; Calcium-Binding Proteins; Contractile Proteins; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Macromolecular Substances; Marine Toxins; Muscle Fibers, Skeletal; Myocardial Contraction; Oxazoles; Papillary Muscles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Pyrans; Rabbits; Spiro Compounds; Structure-Activity Relationship | 1998 |
Inhibitory effect of calyculin A, a Ser/Thr protein phosphatase type I inhibitor, on renin secretion.
Topics: Animals; Enzyme Inhibitors; Female; Kidney Cortex; Male; Marine Toxins; Oxazoles; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Renin | 1998 |
Okadaic acid-induced lens epithelial cell apoptosis requires inhibition of phosphatase-1 and is associated with induction of gene expression including p53 and bax.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Cell Survival; Cycloheximide; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Genes, p53; Lens, Crystalline; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Rabbits | 1998 |
Effects of okadaic acid, calyculin A, and PDBu on state of phosphorylation of rat renal Na+-K+-ATPase.
Topics: Animals; Dopamine and cAMP-Regulated Phosphoprotein 32; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Kidney; Male; Marine Toxins; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 1998 |
Characterization of protein serine/threonine phosphatase activities in human lung mast cells and basophils.
Topics: Basophils; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; In Vitro Techniques; Lung; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 1998 |
Beta 1 integrin-dependent binding of Jurkat cells to fibronectin is regulated by a serine-threonine phosphatase.
Topics: CD3 Complex; Fibronectins; Humans; Integrin beta1; Jurkat Cells; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Signal Transduction | 1998 |
A dopamine/D1 receptor/protein kinase A/dopamine- and cAMP-regulated phosphoprotein (Mr 32 kDa)/protein phosphatase-1 pathway regulates dephosphorylation of the NMDA receptor.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Activation; Enzyme Inhibitors; In Vitro Techniques; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Nucleus Accumbens; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D1; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 1998 |
Expression and characterization of PP7, a novel plant protein Ser/Thr phosphatase distantly related to RdgC/PPEF and PP5.
Topics: Arabidopsis; Arabidopsis Proteins; Calcium-Binding Proteins; Carboxylic Acids; Caseins; Catalytic Domain; Cations, Divalent; Drosophila Proteins; Escherichia coli; Fumonisins; Glycoproteins; Heparin; Hydrogen-Ion Concentration; Inclusion Bodies; Marine Toxins; Myelin Basic Protein; Nitrophenols; Okadaic Acid; Organophosphorus Compounds; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Polylysine; Pregnancy Proteins; Recombinant Fusion Proteins; Substrate Specificity | 1998 |
Temperature-dependent flagellar motility of demembranated, cytosol-free fowl spermatozoa.
Topics: Animals; Calcium; Cell Membrane; Cell Separation; Chelating Agents; Chickens; Cytosol; Detergents; Egtazic Acid; Enzyme Inhibitors; Male; Marine Toxins; Myosin Light Chains; Octoxynol; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Povidone; Protein Kinases; Silicon Dioxide; Sperm Motility; Sperm Tail; Spermatozoa; Temperature | 1998 |
Increased contractility of rat uterine smooth muscle at the end of pregnancy.
Topics: Actins; Animals; Calcium; Enzyme Inhibitors; Female; Marine Toxins; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Oxazoles; Oxytocin; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Pregnancy; Pregnancy, Animal; Protein Kinases; Rats; Rats, Wistar; Type C Phospholipases; Uterus | 1998 |
Regulation of the L-type Ca2+ channel current in rat pinealocytes: role of basal phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic beta-Agonists; Alkaloids; Animals; Antifungal Agents; Calcium Channels; Calcium Channels, L-Type; Carbazoles; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Indoles; Isoproterenol; Isoquinolines; Male; Marine Toxins; Membrane Potentials; Nerve Tissue Proteins; Norepinephrine; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Phosphorylation; Pineal Gland; Protein Kinase C; Pyrans; Rats; Rats, Sprague-Dawley; Spiro Compounds; Sulfonamides; Sympathomimetics | 1999 |
Effects of calyculin A and okadaic acid on acetylcholine release and subcellular distribution in rat hippocampal formation.
Topics: Acetylcholine; Animals; Brain Chemistry; Choline; Enzyme Inhibitors; Hippocampus; Male; Marine Toxins; Neurotransmitter Agents; Okadaic Acid; Organ Culture Techniques; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Subcellular Fractions; Synaptic Vesicles; Tritium | 1999 |
Transcriptional interferences between normal or mutant androgen receptors and the activator protein 1--dissection of the androgen receptor functional domains.
Topics: Aldehyde Reductase; Androgens; Animals; Breast Neoplasms, Male; COS Cells; DNA; Enzyme Inhibitors; Genes, Reporter; Genetic Engineering; Humans; Luciferases; Male; Marine Toxins; Mice; Mutation; Okadaic Acid; Oxazoles; Proteins; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Receptors, Androgen; Staurosporine; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Transcription, Genetic; Transfection | 1999 |
Phosphorylation sites in the integrin beta3 cytoplasmic domain in intact platelets.
Topics: Blood Platelets; Cell Adhesion; Cytoplasm; Humans; Marine Toxins; Oxazoles; Phosphorylation; Platelet Glycoprotein GPIIb-IIIa Complex; Signal Transduction; Threonine | 1999 |
Calyculin A modulates activation of the NADPH-oxidase in Me2SO-differentiated HL-60 cells.
Topics: Arachidonic Acid; Calcium-Calmodulin-Dependent Protein Kinases; Cell Differentiation; Dimethyl Sulfoxide; Enzyme Inhibitors; HL-60 Cells; Humans; Marine Toxins; N-Formylmethionine Leucyl-Phenylalanine; NADPH Oxidases; Neutrophils; Oxazoles; Oxygen; Phosphoprotein Phosphatases; Phosphoproteins; Signal Transduction; Tetradecanoylphorbol Acetate; Time Factors | 1998 |
N-Acetylsphingosine stimulates phosphatidylglycerolphosphate synthase activity in H9c2 cardiac cells.
Topics: Animals; Cardiolipins; Cell Line; Cell Membrane Permeability; Ceramides; Cyclic AMP-Dependent Protein Kinases; DNA; Enzyme Activation; Enzyme Inhibitors; Ligases; Marine Toxins; Mitochondria, Heart; Myocardium; Nucleotides; Okadaic Acid; Oxazoles; Phosphatidylglycerols; Phospholipases A; Phospholipases A2; Phosphoprotein Phosphatases; Rats; Sphingosine; Tumor Necrosis Factor-alpha | 1999 |
Rapid dephosphorylation of p107 following UV irradiation.
Topics: 3T3 Cells; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; DNA-Binding Proteins; E2F Transcription Factors; Enzyme Activation; Enzyme Inhibitors; G1 Phase; Humans; Marine Toxins; Mice; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Retinoblastoma-Binding Protein 1; Retinoblastoma-Like Protein p107; Substrate Specificity; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53; Ultraviolet Rays | 1999 |
The role of protein kinase C in laminin-mediated neurite outgrowth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Membrane; Cell Size; Cell Survival; Cytoplasm; Enzyme Activation; Indoles; Insulin; Lactams; Laminin; Marine Toxins; Neurites; Oxazoles; PC12 Cells; Phosphoprotein Phosphatases; Protein Kinase C; Rats; Signal Transduction; Stereoisomerism; Time Factors | 1999 |
Involvement of calyculin A-sensitive phosphatase(s) in the differentiation of Trypanosoma cruzi trypomastigotes to amastigotes.
Topics: Animals; Antigens, Protozoan; Cell Differentiation; Marine Toxins; Membrane Proteins; Neuraminidase; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Processing, Post-Translational; Trypanosoma cruzi | 1999 |
Molecular characterization of catalytic-subunit cDNA sequences encoding protein phosphatases 1 and 2A and study of their roles in the gibberellin-dependent Osamy-c expression in rice.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Southern; Catalytic Domain; DNA, Complementary; DNA, Plant; Enzyme Inhibitors; Germination; Gibberellins; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oryza; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Rabbits; Sequence Alignment; Signal Transduction | 1999 |
Cobalt chloride-induced signaling in endothelium leading to the augmented adherence of sickle red blood cells and transendothelial migration of monocyte-like HL-60 cells is blocked by PAF-receptor antagonist.
Topics: Adult; Anemia, Sickle Cell; Base Sequence; Calcium-Calmodulin-Dependent Protein Kinases; Cell Adhesion; Cell Movement; Cells, Cultured; Cobalt; E-Selectin; Endothelium, Vascular; Enzyme Inhibitors; Erythrocytes, Abnormal; Flavonoids; HL-60 Cells; Humans; Hypoxia; Indoles; Intercellular Adhesion Molecule-1; Maleimides; Marine Toxins; Mitogen-Activated Protein Kinase 1; Molecular Sequence Data; NF-kappa B; Oxazoles; Phospholipid Ethers; Phosphoprotein Phosphatases; Phosphorylation; Platelet Endothelial Cell Adhesion Molecule-1; Platelet Membrane Glycoproteins; Protein Processing, Post-Translational; Receptors, Cell Surface; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Transcription Factor AP-1; Umbilical Veins; Vascular Cell Adhesion Molecule-1 | 1999 |
Phosphorylation state of hsp27 and p38 MAPK during preconditioning and protein phosphatase inhibitor protection of rabbit cardiomyocytes.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Cytoskeleton; Cytosol; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Intracellular Signaling Peptides and Proteins; Ischemic Preconditioning, Myocardial; Marine Toxins; Mitogen-Activated Protein Kinases; Myocardium; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Rabbits; Time Factors | 1999 |
Protein phosphatase 2A interacts with the 70-kDa S6 kinase and is activated by inhibition of FKBP12-rapamycinassociated protein.
Topics: Carrier Proteins; Enzyme Inhibitors; Glutathione Transferase; Humans; Immunophilins; Jurkat Cells; Kinetics; Marine Toxins; Models, Biological; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Phosphatase 2; Recombinant Fusion Proteins; Ribosomal Protein S6 Kinases; Sirolimus; Tacrolimus Binding Proteins; TOR Serine-Threonine Kinases; Transfection | 1999 |
The Rho-related protein Rnd1 inhibits Ca2+ sensitization of rat smooth muscle.
Topics: Animals; Blotting, Western; Calcium Signaling; Carbachol; Cell Membrane; Enzyme Inhibitors; Gonadal Steroid Hormones; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; In Vitro Techniques; Isometric Contraction; Marine Toxins; Muscarinic Agonists; Muscle, Smooth; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Recombinant Proteins; rho GTP-Binding Proteins | 1999 |
The solution structures of calyculin A and dephosphonocalyculin A by NMR.
Topics: Animals; Magnetic Resonance Spectroscopy; Marine Toxins; Models, Chemical; Oxazoles; Porifera; Solutions | 1999 |
Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neurons.
Topics: Animals; Calcineurin; Calcineurin Inhibitors; Cyclosporine; Dopamine and cAMP-Regulated Phosphoprotein 32; Drug Combinations; Drug Synergism; Enzyme Inhibitors; In Vitro Techniques; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Neostriatum; Nerve Tissue Proteins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2 | 1999 |
TNF-alpha and IL-1alpha induce heme oxygenase-1 via protein kinase C, Ca2+, and phospholipase A2 in endothelial cells.
Topics: Acetylcysteine; Blotting, Northern; Calcimycin; Calcium; Carcinogens; Cells, Cultured; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Free Radical Scavengers; Gene Expression Regulation, Enzymologic; Heme Oxygenase (Decyclizing); Heme Oxygenase-1; Humans; Interleukin-1; Ionophores; Marine Toxins; Membrane Proteins; Okadaic Acid; Oxazoles; Phospholipases A; Phospholipases A2; Protein Kinase C; Reactive Oxygen Species; RNA, Messenger; Second Messenger Systems; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Umbilical Veins | 1999 |
Regulation of Na+-K+-2Cl- cotransport in turkey red cells: the role of oxygen tension and protein phosphorylation.
Topics: Adrenergic beta-Agonists; Animals; Carrier Proteins; Dithiothreitol; Drug Interactions; Enzyme Inhibitors; Erythrocytes; Ethylmaleimide; Isoproterenol; Marine Toxins; Oxazoles; Oxygen; Partial Pressure; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Sodium-Potassium-Chloride Symporters; Staurosporine; Turkeys | 1999 |
Relaxation of contracted rabbit tracheal and human bronchial smooth muscle by Y-27632 through inhibition of Ca2+ sensitization.
Topics: 1-Methyl-3-isobutylxanthine; Amides; Animals; Bronchi; Calcium; Carbachol; Cholinergic Agents; Detergents; Dose-Response Relationship, Drug; Endothelin-1; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Marine Toxins; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Octoxynol; Oxazoles; Phosphodiesterase Inhibitors; Protein Serine-Threonine Kinases; Pyridines; Rabbits; rho-Associated Kinases; Signal Transduction; Trachea; Type C Phospholipases | 1999 |
Regulation of Na+-K+-2Cl- cotransport by protein phosphorylation in ferret erythrocytes.
Topics: Animals; Blood Proteins; Carrier Proteins; Chlorides; Enzyme Inhibitors; Erythrocytes; Ferrets; Homeostasis; Kinetics; Magnesium; Marine Toxins; Models, Biological; Oxazoles; Phosphorylation; Potassium; Pyrazoles; Pyrimidines; Rubidium; Sodium; Sodium-Potassium-Chloride Symporters; Staurosporine | 1999 |
Association between G2-phase block and repair of radiation-induced chromosome fragments in human lymphocytes.
Topics: Adult; Chromosome Aberrations; Chromosomes; G2 Phase; Humans; Lymphocytes; Male; Marine Toxins; Oxazoles | 1999 |
Augmentation of methylprednisolone-induced differentiation of myeloid leukemia cells by serine/threonine protein phosphatase inhibitors.
Topics: Cell Death; Cell Differentiation; Enzyme Inhibitors; HL-60 Cells; Humans; Leukemia, Myeloid; Marine Toxins; Methylprednisolone; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 1999 |
Role of tyrosine phosphorylation of flagellar proteins in hamster sperm hyperactivation.
Topics: Animals; Bucladesine; Cricetinae; Culture Media; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Kinetics; Male; Marine Toxins; Mesocricetus; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein-Tyrosine Kinases; Proteins; Sperm Capacitation; Sperm Tail; Spermatozoa | 1999 |
Hyperactivation of hamster sperm motility by temperature-dependent tyrosine phosphorylation of an 80-kDa protein.
Topics: Animals; Cell Membrane; Cricetinae; Male; Marine Toxins; Molecular Weight; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Sperm Motility; Sperm Tail; Temperature | 1999 |
Differential regulation of tumor necrosing factor-alpha (TNF-alpha) and interleukin-10 (IL-10) secretion by protein kinase and phosphatase inhibitors in human alveolar macrophages.
Topics: Cells, Cultured; Enzyme Inhibitors; Gene Expression Regulation; Humans; Inflammation; Interleukin-10; Lipopolysaccharides; Macrophages, Alveolar; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Protein Kinase Inhibitors; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha | 1999 |
Participation of cytosolic protein phosphatase in regulation of NADPH oxidase in polymorphonuclear leukocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cytosol; Female; Guinea Pigs; Marine Toxins; NADPH Oxidases; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rabbits; Superoxides; Tetradecanoylphorbol Acetate | 1999 |
Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Animals; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Enzyme Inhibitors; Insulin; Marine Toxins; Okadaic Acid; Oxazoles; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; Rats | 1999 |
G(i) protein-mediated functional compartmentalization of cardiac beta(2)-adrenergic signaling.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Animals; Calcium Channels; Calcium Channels, L-Type; Calcium-Binding Proteins; Cell Size; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Ethanolamines; GTP-Binding Protein alpha Subunits, Gi-Go; Heart; Heart Ventricles; Marine Toxins; Myocardial Contraction; Myocardium; Oxazoles; Pertussis Toxin; Phosphorylation; Propanolamines; Rats; Receptors, Adrenergic, beta-2; Signal Transduction; Thionucleotides; Vasoconstrictor Agents; Virulence Factors, Bordetella | 1999 |
Osmotic stress inhibits p70/85 S6 kinase through activation of a protein phosphatase.
Topics: Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Cycle Proteins; Cell Line; Chlorocebus aethiops; Enzyme Activation; Humans; Marine Toxins; Mutation; Osmotic Pressure; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Ribosomal Protein S6 Kinases; Sirolimus; Ultraviolet Rays | 1999 |
Inorganic phosphate regulates CryIVA protoxin expression in Bacillus thuringiensis israelensis.
Topics: Bacillus thuringiensis; Bacillus thuringiensis Toxins; Bacterial Proteins; Bacterial Toxins; Endotoxins; Enzyme Activation; Gene Expression Regulation, Bacterial; Hemolysin Proteins; Insecticides; Marine Toxins; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Protein Precursors; Protein Serine-Threonine Kinases; Sodium Fluoride | 1999 |
Enzyme activity and protein of multiple forms of choline acetyltransferase: effects of calyculin A and okadaic acid.
Topics: Animals; Choline O-Acetyltransferase; Enzyme Inhibitors; Hippocampus; Isoenzymes; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Subcellular Fractions | 1999 |
Protein phosphatase 2C inactivates F-actin binding of human platelet moesin.
Topics: Actins; Animals; Blood Platelets; Cattle; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Microfilament Proteins; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 2; Protein Phosphatase 2C; Saccharomyces cerevisiae Proteins | 1999 |
Store-operated Ca2+ entry: evidence for a secretion-like coupling model.
Topics: Actins; Animals; Calcium; Calcium Channels; Calcium Signaling; Cell Line, Transformed; Cell Membrane; Cells, Cultured; Cytochalasin D; Cytoskeleton; Endoplasmic Reticulum; Inositol 1,4,5-Trisphosphate; Ion Channel Gating; Ion Transport; Marine Toxins; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats | 1999 |
Inhibition of protein phosphatase 2A induces serine/threonine phosphorylation, subcellular redistribution, and functional inhibition of STAT3.
Topics: Calcineurin Inhibitors; CD4-Positive T-Lymphocytes; Cell Nucleus; Cyclosporine; Cytoplasm; DNA-Binding Proteins; Enzyme Inhibitors; Humans; Marine Toxins; Microscopy, Confocal; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Serine; Signal Transduction; STAT3 Transcription Factor; Staurosporine; Threonine; Trans-Activators; Tumor Cells, Cultured | 1999 |
The protein phosphatase inhibitors, okadaic acid and calyculin A, induce apoptosis in human submandibular gland ductal cell line HSG cells.
Topics: Apoptosis; Cells, Cultured; Cycloheximide; Dactinomycin; DNA Fragmentation; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Synthesis Inhibitors; Salivary Ducts; Submandibular Gland | 1999 |
Proteasome inhibitors lactacystin and MG132 inhibit the dephosphorylation of HSF1 after heat shock and suppress thermal induction of heat shock gene expression.
Topics: Acetylcysteine; Animals; Cell Line; Cysteine Proteinase Inhibitors; DNA; DNA-Binding Proteins; Down-Regulation; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Proteins; Hot Temperature; HSP70 Heat-Shock Proteins; JNK Mitogen-Activated Protein Kinases; Leupeptins; Marine Toxins; Mice; Mitogen-Activated Protein Kinases; Oxazoles; Phosphorylation; Transcription Factors | 1999 |
Distinct roles for PP1 and PP2A in phosphorylation of the retinoblastoma protein. PP2a regulates the activities of G(1) cyclin-dependent kinases.
Topics: 3T3 Cells; Animals; Antifungal Agents; Cyclin G; Cyclin G1; Cyclin-Dependent Kinases; Cyclins; Enzyme Inhibitors; Isoenzymes; Marine Toxins; Mice; Mice, Inbred BALB C; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Pyrans; Retinoblastoma Protein; Spiro Compounds | 1999 |
Hepatic toxicity and persistence of ser/thr protein phosphatase inhibition by microcystin in the little skate Raja erinacea.
Topics: Animals; Cell Adhesion; Cell Size; Cells, Cultured; Cholic Acids; Coloring Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Hemorrhage; Kidney; Liver; Male; Marine Toxins; Microcystins; Necrosis; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Salt Gland; Sharks; Skates, Fish | 1999 |
Mode-specific inhibition of sodium-calcium exchange during protein phosphatase blockade.
Topics: Animals; Barium; Cattle; CHO Cells; Cricetinae; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Sodium-Calcium Exchanger; Spectrometry, Fluorescence; Transfection | 1999 |
Serine/threonine protein phosphatases and regulation of K-Cl cotransport in human erythrocytes.
Topics: Anemia, Sickle Cell; Biological Transport; Carrier Proteins; Cell Size; Cytosol; Dehydration; Enzyme Inhibitors; Erythrocytes; Humans; Ionophores; K Cl- Cotransporters; Marine Toxins; Membrane Proteins; Nystatin; Okadaic Acid; Osmolar Concentration; Oxazoles; Phosphoprotein Phosphatases; Serine; Symporters; Threonine; Water-Electrolyte Balance | 1999 |
Polycations induce calcium signaling in glomerular podocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Benzoquinones; Calcium Signaling; Cells, Cultured; DEAE-Dextran; Heparin; Kidney Glomerulus; Lactams, Macrocyclic; Marine Toxins; Mice; Muramidase; Oxazoles; Protamines; Quinones; Rifabutin; Staurosporine; Thapsigargin | 1999 |
Balance between activities of Rho kinase and type 1 protein phosphatase modulates turnover of phosphorylation and dynamics of desmin/vimentin filaments.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Cycle; Cell Line; Desmin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Immunoblotting; Intracellular Signaling Peptides and Proteins; Marine Toxins; Mice; Microscopy, Confocal; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Recombinant Proteins; rho-Associated Kinases; Time Factors; Vimentin | 1999 |
Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors.
Topics: 3T3 Cells; Animals; Antifungal Agents; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases; Cell Line; Cell Line, Transformed; Enzyme Inhibitors; Gene Expression; Humans; Intracellular Fluid; Marine Toxins; Mice; Microcystins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Pyrans; Rats; Rats, Wistar; Spiro Compounds; Tumor Cells, Cultured | 1999 |
Modulation of human neutrophil responses to CD32 cross-linking by serine/threonine phosphatase inhibitors: cross-talk between serine/threonine and tyrosine phosphorylation.
Topics: Adult; Calcium; Calcium Signaling; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Neutrophil Activation; Neutrophils; Oncogene Protein v-cbl; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Receptors, IgG; Retroviridae Proteins, Oncogenic; Serine; Superoxides; Threonine; Tyrosine | 2000 |
Down-regulation by extracellular ATP of rat hepatocyte organic anion transport is mediated by serine phosphorylation of oatp1.
Topics: Adenosine Triphosphate; Animals; Anion Transport Proteins; Biological Transport; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Kinetics; Liver; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphopeptides; Phosphorylation; Phosphoserine; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; Sulfobromophthalein | 2000 |
Fas-mediated apoptosis in T cells involves the dephosphorylation of the retinoblastoma protein by type 1 protein phosphatases.
Topics: Apoptosis; Cell Membrane; DNA Fragmentation; Enzyme Inhibitors; fas Receptor; Humans; Jurkat Cells; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteins; Retinoblastoma Protein; T-Lymphocytes | 1999 |
Synthesis and biological evaluation of a targeted library of protein phosphatase inhibitors.
Topics: Databases as Topic; Drug Design; Enzyme Inhibitors; Ethers, Cyclic; Humans; Indicators and Reagents; Kinetics; Marine Toxins; Microcystins; Models, Molecular; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Structure-Activity Relationship | 2000 |
Serine/threonine phosphorylation in cellular signaling for alveolar macrophage phagocytic response to endotoxin.
Topics: Animals; Cells, Cultured; JNK Mitogen-Activated Protein Kinases; Lipopolysaccharides; Macrophages, Alveolar; Male; Marine Toxins; Mitogen-Activated Protein Kinases; Okadaic Acid; Oxazoles; Phagocytosis; Phosphorylation; Phosphoserine; Phosphothreonine; Rats; Rats, Sprague-Dawley; Signal Transduction | 2000 |
Induction of apoptosis in human oral squamous carcinoma cell lines by protein phosphatase inhibitors.
Topics: Apoptosis; Carcinoma, Squamous Cell; Enzyme Inhibitors; Humans; Marine Toxins; Mouth Neoplasms; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tumor Cells, Cultured | 1999 |
Activation of p38 mitogen-activated protein kinase and mitochondrial Ca(2+)-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A.
Topics: Acetylcysteine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Carrier Proteins; Egtazic Acid; Endoplasmic Reticulum Chaperone BiP; Enzyme Inhibitors; Heat-Shock Proteins; Imidazoles; Marine Toxins; Mitochondria; Mitogen-Activated Protein Kinases; Molecular Chaperones; Okadaic Acid; Oxazoles; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Proline; Promoter Regions, Genetic; Pyridines; Rats; RNA, Messenger; Ruthenium Red; Thiocarbamates; Transcriptional Activation; Tumor Cells, Cultured | 2000 |
Mechanisms of cGMP-dependent mesangial-cell relaxation: a role for myosin light-chain phosphatase activation.
Topics: Angiotensin II; Animals; Azepines; Calcium; Calcium Signaling; Cell Size; Cells, Cultured; Dibutyryl Cyclic GMP; Dose-Response Relationship, Drug; Enzyme Activation; Glomerular Mesangium; Marine Toxins; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Inhibition of protein phosphatase-1 by clavosines A and B. Novel members of the calyculin family of toxins.
Topics: Animals; Cattle; Enzyme Inhibitors; Escherichia coli; Humans; Hydrogen Bonding; Marine Toxins; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Myocardium; Organophosphates; Oxazoles; Phosphoprotein Phosphatases; Protein Binding; Protein Phosphatase 1; Recombinant Proteins; Tyrosine | 2000 |
K-Cl cotransport in vascular smooth muscle and erythrocytes: possible implication in vasodilation.
Topics: Alkaloids; Animals; Aorta; Biological Transport; Carbazoles; Carrier Proteins; Cells, Cultured; Chlorides; Coronary Vessels; Enzyme Inhibitors; Erythrocytes; Ethylmaleimide; Genistein; Hydralazine; Indoles; Isometric Contraction; Isosorbide Dinitrate; K Cl- Cotransporters; Marine Toxins; Muscle, Smooth, Vascular; Nitric Oxide; Nitroprusside; Oxazoles; Potassium; Propylene Glycols; Rats; Rubidium; Sheep; Swine; Symporters; Vasoconstriction; Vasodilation; Vasodilator Agents | 2000 |
Cholinergic-induced Ca2+ elevation in rat lacrimal gland acini is negatively modulated by PKCdelta and PKCepsilon.
Topics: Animals; Calcium; Carbachol; Cholinergic Agonists; Enzyme Activation; Enzyme Inhibitors; Fura-2; Isoenzymes; Lacrimal Apparatus; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; Protein Kinase C-epsilon; Rats; Rats, Wistar; Staurosporine; Tetradecanoylphorbol Acetate; Thapsigargin | 2000 |
Identification of novel serine/threonine protein phosphatases in Trypanosoma cruzi: a potential role in control of cytokinesis and morphology.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Northern; Blotting, Southern; Escherichia coli; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; RNA, Messenger; Trypanosoma cruzi | 2000 |
Hamster pancreatic beta cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors.
Topics: Animals; Apoptosis; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cantharidin; Cell Division; Cell Line; Cricetinae; Drug Resistance, Multiple; Enzyme Inhibitors; Gene Expression; Islets of Langerhans; Marine Toxins; Okadaic Acid; Oxazoles; Phenotype; Phosphoprotein Phosphatases; Signal Transduction | 2000 |
Protein phosphatase-protein kinase interplay modulates alpha 1b-adrenoceptor phosphorylation: effects of okadaic acid.
Topics: Animals; Antifungal Agents; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Kinetics; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Pyrans; Pyrethrins; Rats; Receptors, Adrenergic, alpha-1; Spiro Compounds; Staurosporine; Tetradecanoylphorbol Acetate | 2000 |
Transient translocation and activation of protein phosphatase 2A during mast cell secretion.
Topics: Animals; Antigens; beta-N-Acetylhexosaminidases; Calcimycin; Cell Line; Dinitrophenols; Enzyme Activation; Immunoglobulin E; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Rats; Serum Albumin, Bovine; Signal Transduction; Tetradecanoylphorbol Acetate | 2000 |
Requirement of the inositol trisphosphate receptor for activation of store-operated Ca2+ channels.
Topics: Actins; Boron Compounds; Calcium; Calcium Channels; Calcium Signaling; Carbachol; Cell Line; Cell Membrane; Diglycerides; Endoplasmic Reticulum; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate Receptors; Ionomycin; Macrocyclic Compounds; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Receptors, Cytoplasmic and Nuclear; Strontium; Thapsigargin; Transfection; TRPC Cation Channels; Type C Phospholipases | 2000 |
The possible role of protein-carboxyl methylation in the regulation of flagellar movement of fowl spermatozoa.
Topics: Adenosine; Adenosine Triphosphate; Animals; Calcium Chloride; Chickens; Enzyme Inhibitors; Homocysteine; Luminescent Measurements; Male; Marine Toxins; Methylation; Oxazoles; Proteins; Semen; Sperm Motility; Sperm Tail; Tubercidin | 2000 |
A role for the actin cytoskeleton in the initiation and maintenance of store-mediated calcium entry in human platelets. Evidence for conformational coupling.
Topics: Actins; Biological Transport; Blood Platelets; Brefeldin A; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cell Membrane; Cytochalasin D; Cytoskeleton; Depsipeptides; Endoplasmic Reticulum; Humans; Inositol 1,4,5-Trisphosphate; Marine Toxins; Models, Biological; Oxazoles; Peptides, Cyclic; Thiazoles; Thiazolidines | 2000 |
Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4/HER4.
Topics: 3T3 Cells; ADAM Proteins; ADAM17 Protein; Animals; Clone Cells; Cloning, Molecular; Colforsin; Disintegrins; Drosophila Proteins; ErbB Receptors; Kinetics; Marine Toxins; Metalloendopeptidases; Mice; Mice, Inbred C57BL; Mice, Knockout; Okadaic Acid; Oxazoles; Protein Isoforms; Receptor, ErbB-4; Recombinant Proteins; Substrate Specificity; Tetradecanoylphorbol Acetate; Thapsigargin; Transfection; Tumor Necrosis Factor-alpha; Vanadates | 2000 |
Cyclic AMP-induced expression of steroidogenic acute regulatory protein is dependent upon phosphoprotein phosphatase activities.
Topics: Adrenal Cortex; Animals; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Hydroxycholesterols; Isoenzymes; Kinetics; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoproteins; Pregnenolone; Progesterone; Protein Tyrosine Phosphatases; Steroids | 2000 |
Farnesyltransferase inhibitor induces rapid growth arrest and blocks p70s6k activation by multiple stimuli.
Topics: Alkyl and Aryl Transferases; Animals; Cell Division; Cell Line; Enzyme Activation; Enzyme Inhibitors; Farnesyltranstransferase; Keratinocytes; Marine Toxins; Methionine; Mice; Oxazoles; Phosphorylation; Ribosomal Protein S6 Kinases; Sirolimus; Tetradecanoylphorbol Acetate | 2000 |
Myeloid cell leukemia 1 is phosphorylated through two distinct pathways, one associated with extracellular signal-regulated kinase activation and the other with G2/M accumulation or protein phosphatase 1/2A inhibition.
Topics: Burkitt Lymphoma; Cell Cycle; Cell Survival; Enzyme Activation; Enzyme Inhibitors; G2 Phase; Humans; Marine Toxins; Microtubules; Mitogen-Activated Protein Kinases; Mitosis; Myeloid Cell Leukemia Sequence 1 Protein; Neoplasm Proteins; Nocodazole; Okadaic Acid; Oxazoles; Paclitaxel; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-bcl-2; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Vinblastine | 2000 |
Effect of okadaic acid and calyculin-A, two protein phosphatase inhibitors, on thyrotropin-stimulated triiodothyronine secretion in cultured sheep thyroid cells.
Topics: Animals; Cells, Cultured; Colforsin; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Sheep; Thyroid Gland; Thyrotropin; Triiodothyronine | 1999 |
Ca2+ signalling in rat vascular smooth muscle cells: a role for protein kinase C at physiological vasoconstrictor concentrations of vasopressin.
Topics: Action Potentials; Animals; Calcium; Calcium Signaling; Carcinogens; Cells, Cultured; Marine Toxins; Muscle, Smooth, Vascular; Oxazoles; Potassium; Protein Kinase C; Protein Serine-Threonine Kinases; Rats; Tetradecanoylphorbol Acetate; Vasoconstrictor Agents; Vasopressins | 2000 |
Involvement of histone phosphorylation in thymocyte apoptosis by protein phosphatase inhibitors.
Topics: Animals; Apoptosis; Cells, Cultured; Enzyme Inhibitors; Histones; Marine Toxins; Okadaic Acid; Oxazoles; Phosphates; Phosphorylation; Protein Tyrosine Phosphatases; Rats; Rats, Sprague-Dawley; T-Lymphocytes; Thymus Gland | 1999 |
Effect of Ca(2+)-independent mechanisms on the hypoxic relaxation of guinea-pig tracheal rings.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Calcium; Enzyme Inhibitors; Guinea Pigs; Hypoxia; Male; Marine Toxins; Muscle Relaxation; Muscle, Smooth; Okadaic Acid; Oxazoles; Oxygen; Thapsigargin; Trachea | 2000 |
Assessment of the marine toxins by monitoring the integrity of human intestinal Caco-2 cell monolayers.
Topics: Actins; Caco-2 Cells; Cytoskeleton; Electric Impedance; Humans; Intestinal Mucosa; Marine Toxins; Oxazoles; Protein Synthesis Inhibitors; Tight Junctions | 2000 |
Synergetic activation of p38 mitogen-activated protein kinase and caspase-3-like proteases for execution of calyculin A-induced apoptosis but not N-methyl-d-aspartate-induced necrosis in mouse cortical neurons.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase 3; Caspases; Cells, Cultured; Cerebral Cortex; Cysteine Proteinase Inhibitors; Drug Synergism; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fetus; Imidazoles; Marine Toxins; Mice; Mitogen-Activated Protein Kinases; N-Methylaspartate; Necrosis; Neurons; Neurotoxins; Oxazoles; p38 Mitogen-Activated Protein Kinases; Receptors, N-Methyl-D-Aspartate; tau Proteins | 2000 |
A peptide of the alpha 3(IV) chain of type IV collagen modulates stimulated neutrophil function via activation of cAMP-dependent protein kinase and Ser/Thr protein phosphatase.
Topics: Adenosine; Amino Acid Sequence; Autoantigens; Calcium; Carbazoles; Chelating Agents; Collagen; Collagen Type IV; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine Antagonists; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; Indoles; Marine Toxins; Molecular Sequence Data; Neutrophils; Okadaic Acid; Oxazoles; Peptide Fragments; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Pyrroles; Pyrrolidinones; Respiratory Burst; Signal Transduction; Thapsigargin; Trifluoperazine | 2000 |
Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing.
Topics: Androstadienes; Animals; Cell Line; Cell Nucleus; Chelating Agents; Cobalt; Cytosol; Deferoxamine; DNA-Binding Proteins; Dose-Response Relationship, Drug; Electron Transport Complex III; Electron Transport Complex IV; Enzyme Inhibitors; Genes, Reporter; Humans; Hydrogen Peroxide; Hypoxia; Hypoxia-Inducible Factor 1; Hypoxia-Inducible Factor 1, alpha Subunit; Immunoblotting; Marine Toxins; Mitochondria; Mitochondria, Liver; Models, Biological; Nuclear Proteins; Oxazoles; Oxidation-Reduction; Oxygen; Paracoccus denitrificans; Rats; Reactive Oxygen Species; Time Factors; Transcription Factors; Transfection; Tumor Cells, Cultured; Wortmannin | 2000 |
Chiral action at a distance: remote substituent effects on the optical activity of calyculins A and B.
Topics: Biological Factors; Carcinogens; Enzyme Inhibitors; Marine Toxins; Models, Molecular; Molecular Conformation; Optical Rotation; Organophosphates; Oxazoles; Phosphoprotein Phosphatases; Stereoisomerism; Thermodynamics; Vasoconstrictor Agents | 2000 |
Cyclic AMP blocks bacterial lipopolysaccharide-induced myosin light chain phosphorylation in endothelial cells through inhibition of Rho/Rho kinase signaling.
Topics: 1-Methyl-3-isobutylxanthine; Cells, Cultured; Cyclic AMP; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Marine Toxins; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction; Transcription, Genetic; Umbilical Veins | 2000 |
Oxygen uptake, acidification of medium and nitrate uptake induced by blue light in nitrate-starved Chlorella cells.
Topics: Biological Transport; Chlorella; Color; Glycine; Light; Marine Toxins; Nitrates; Okadaic Acid; Oxazoles; Oxygen; Phosphoprotein Phosphatases | 2000 |
Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia.
Topics: Animals; Antibodies, Monoclonal; Basal Ganglia; Cattle; Cocaine; Corpus Striatum; Cyclosporine; Dopamine and cAMP-Regulated Phosphoprotein 32; Dopamine Uptake Inhibitors; Enzyme Inhibitors; Illicit Drugs; Marine Toxins; Methamphetamine; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Rats | 2000 |
Protein phosphatase inhibitors alter cellular microtubules and reduce carbachol-dependent protein secretion in lacrimal acini.
Topics: Animals; Carbachol; Cholinergic Agonists; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Eye Proteins; Female; Lacrimal Apparatus; Marine Toxins; Microscopy, Confocal; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rabbits | 2000 |
Differential translocation or phosphorylation of alpha B crystallin cannot be detected in ischemically preconditioned rabbit cardiomyocytes.
Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Crystallins; Cytoskeleton; Cytosol; Enzyme Inhibitors; Flavonoids; Heart Ventricles; Hydrogen-Ion Concentration; Imidazoles; Immunoblotting; Ischemic Preconditioning, Myocardial; Isoelectric Focusing; Lens, Crystalline; Marine Toxins; Mitogen-Activated Protein Kinases; Myocardium; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Protein Isoforms; Pyridines; Rabbits; Time Factors | 2000 |
Inhibition and stimulation of growth of Entamoeba histolytica in culture: association with PKC activity and protein phosphorylation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Culture Media; Down-Regulation; Entamoeba histolytica; Enzyme Inhibitors; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Threonine | 2000 |
The F-actin cytoskeleton modulates slow secretory components rather than readily releasable vesicle pools in bovine chromaffin cells.
Topics: Actins; Adrenal Glands; Animals; Bridged Bicyclo Compounds, Heterocyclic; Carcinogens; Cattle; Cell Membrane; Chromaffin Cells; Cytoplasmic Granules; Cytoskeleton; Electrophysiology; Enzyme Inhibitors; Exocytosis; Marine Toxins; Membrane Potentials; Microscopy, Electron; Oxazoles; Phosphorylation; Tetradecanoylphorbol Acetate; Thiazoles; Thiazolidines | 2000 |
Inhibition of antigen and calcium ionophore induced secretion from RBL-2H3 cells by phosphatase inhibitors.
Topics: Animals; Antigens; Calcimycin; Calcium; Calcium Signaling; Cell Adhesion; Cell Membrane; Cell Size; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ionophores; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Signal Transduction; Vimentin | 1998 |
Phosphoprotein phosphatases regulate steroidogenesis by influencing StAR gene transcription.
Topics: Adrenal Cortex; Animals; Cell Line; Colforsin; Dose-Response Relationship, Drug; Gene Expression Regulation; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Pregnenolone; Protein Phosphatase 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Steroids; Transcription, Genetic | 2000 |
Rapid dephosphorylation of H1 histones after apoptosis induction.
Topics: Apoptosis; Deoxyribonucleases; DNA Fragmentation; DNA, Neoplasm; Enzyme Activation; Histones; HL-60 Cells; Humans; Marine Toxins; Nucleosomes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Staurosporine; Tetradecanoylphorbol Acetate; Topotecan | 2000 |
Calyculin A-induced vimentin phosphorylation sequesters 14-3-3 and displaces other 14-3-3 partners in vivo.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Animals; COS Cells; Enzyme Inhibitors; Marine Toxins; Molecular Sequence Data; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Signal Transduction; Tyrosine 3-Monooxygenase; Vimentin | 2000 |
Effect of calyculin A on the surface structure of unfertilized sea urchin eggs.
Topics: Acrosome Reaction; Animals; Cytochalasin B; Enzyme Inhibitors; Fertilization; In Vitro Techniques; Marine Toxins; Microscopy, Electron; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Microvilli; Okadaic Acid; Ovum; Oxazoles; Phosphoprotein Phosphatases; Sea Urchins; Sperm-Ovum Interactions | 2000 |
Glucocorticoids abate p70(S6k) and eIF4E function in L6 skeletal myoblasts.
Topics: Cell Line; Dexamethasone; Enzyme Inhibitors; Eukaryotic Initiation Factor-4E; Glucocorticoids; Marine Toxins; Muscle, Skeletal; Okadaic Acid; Oxazoles; Peptide Initiation Factors; Phosphorylation; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins | 2000 |
Threonine phosphorylation of the beta 3 integrin cytoplasmic tail, at a site recognized by PDK1 and Akt/PKB in vitro, regulates Shc binding.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Sequence; Antigens, CD; Binding Sites; Blood Platelets; Blotting, Western; CDC2 Protein Kinase; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Humans; Integrin beta3; Intramolecular Transferases; Kinetics; Marine Toxins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxazoles; Peptides; Phosphorylation; Phosphotyrosine; Platelet Aggregation; Platelet Membrane Glycoproteins; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins pp60(c-src); Signal Transduction; src Homology Domains; Threonine; Time Factors | 2000 |
Modulation of hypothalamic NMDA receptor function by cyclic AMP-dependent protein kinase and phosphatases.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Hypothalamus; Isoquinolines; Kinetics; Marine Toxins; N-Methylaspartate; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; RNA, Messenger; Sulfonamides; Xenopus laevis | 2000 |
Protein kinase C and phosphatase inhibitors block the ability of angiotensin I-converting enzyme inhibitors to resensitize the receptor to bradykinin without altering the primary effects of bradykinin.
Topics: Angiotensin-Converting Enzyme Inhibitors; Animals; Arachidonic Acid; Bradykinin; Bradykinin Receptor Antagonists; Calcium; Cells, Cultured; CHO Cells; Cricetinae; Drug Interactions; Enalaprilat; Endothelium, Vascular; Enzyme Inhibitors; Humans; Marine Toxins; Naphthalenes; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Pulmonary Artery; Receptor, Bradykinin B2; Receptors, Bradykinin; Transfection | 2000 |
Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4.
Topics: Animals; Barium Compounds; Biological Transport; Bumetanide; Carrier Proteins; Chlorides; Ethylmaleimide; Furosemide; Humans; K Cl- Cotransporters; Kinetics; Marine Toxins; Mice; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Potassium; Protein Isoforms; Protein Phosphatase 1; Pyrethrins; Recombinant Proteins; Rubidium; Sharks; Symporters; Xenopus laevis | 2000 |
Suramin inhibits initiation of defense signaling by systemin, chitosan, and a beta-glucan elicitor in suspension-cultured Lycopersicon peruvianum cells.
Topics: Chitin; Chitosan; Erythrosine; Glucans; Marine Toxins; Oxazoles; Peptides; Phosphorylation; Plant Cells; Plants; Protease Inhibitors; Protein Binding; Signal Transduction; Suramin; Tyrosine | 2000 |
Phosphatase inhibitors and premature chromosome condensation in human peripheral lymphocytes at different cell-cycle phases.
Topics: Calcimycin; Cell Cycle; Chromosomes, Human; Enzyme Inhibitors; Humans; Ionophores; Lymphocytes; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Tetradecanoylphorbol Acetate | 1999 |
ATP induces dephosphorylation of myosin light chain in endothelial cells.
Topics: Adenosine Triphosphate; Animals; Azepines; Calcium; Cells, Cultured; Chelating Agents; Cytosol; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Macrocyclic Compounds; Marine Toxins; Myosin Light Chains; Naphthalenes; Osmolar Concentration; Oxazoles; Phosphorylation; Swine | 2000 |
The relationship between hypotonically-induced taurine and K fluxes in trout red blood cells.
Topics: Animals; Biological Transport; Cell Size; Chlorides; Enzyme Inhibitors; Erythrocytes; Ethylmaleimide; Hypotonic Solutions; Marine Toxins; Oncorhynchus mykiss; Osmolar Concentration; Oxazoles; Potassium; Sodium; Staurosporine; Taurine | 2000 |
beta2-adaptin is constitutively de-phosphorylated by serine/threonine protein phosphatase PP2A and phosphorylated by a staurosporine-sensitive kinase.
Topics: Adaptor Protein Complex beta Subunits; Antifungal Agents; Cell Membrane; Cells, Cultured; Endocytosis; Enzyme Inhibitors; Humans; Jurkat Cells; Marine Toxins; Membrane Proteins; Microscopy, Confocal; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinases; Protein Phosphatase 2; Pyrans; Spiro Compounds; Staurosporine | 2000 |
Myosin light chain kinase transference induces myosin light chain activation and endothelial hyperpermeability.
Topics: Actins; Animals; Azepines; beta Catenin; Biological Transport; Cattle; Cell Membrane Permeability; Cells, Cultured; Chickens; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Inhibitors; Marine Toxins; Myosin Light Chains; Myosin-Light-Chain Kinase; Oxazoles; Phosphorylation; Polyamines; Serum Albumin; Trans-Activators; Up-Regulation | 2000 |
STIM1: a novel phosphoprotein located at the cell surface.
Topics: Amino Acid Sequence; Antibodies; Biotinylation; Cell Line; Cell Membrane; Fluorescent Antibody Technique; Glycosylation; Humans; Immunoblotting; Marine Toxins; Membrane Proteins; Neoplasm Proteins; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Precipitin Tests; Protein Processing, Post-Translational; Stromal Interaction Molecule 1; Tumor Cells, Cultured | 2000 |
Centrosome-directed translocation of Weibel-Palade bodies is rapidly induced by thrombin, calyculin A, or cytochalasin B in human aortic endothelial cells.
Topics: Adult; Aorta; Cells, Cultured; Centrosome; Cytochalasin B; Demecolcine; Endothelium, Vascular; Exocytosis; Female; Fluorescent Antibody Technique; Humans; Marine Toxins; Microscopy, Electron; Microtubules; Middle Aged; Oxazoles; Protein Transport; Thrombin; Vimentin; Weibel-Palade Bodies | 2000 |
Stimulation of hepatocyte growth factor production in human fibroblasts by the protein phosphatase inhibitor okadaic acid.
Topics: Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Fibroblasts; Hepatocyte Growth Factor; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 2000 |
Cocaine and antidepressant-sensitive biogenic amine transporters exist in regulated complexes with protein phosphatase 2A.
Topics: Animals; Antidepressive Agents; Biogenic Amines; Biological Transport; Carrier Proteins; Cell Line; Cocaine; Dopamine Plasma Membrane Transport Proteins; Humans; Macromolecular Substances; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Nerve Tissue Proteins; Norepinephrine Plasma Membrane Transport Proteins; Okadaic Acid; Oxazoles; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Kinase C; Protein Phosphatase 1; Protein Phosphatase 2; Protein Transport; Serotonin; Serotonin Plasma Membrane Transport Proteins; Symporters; Transfection | 2000 |
Reciprocal regulation of glycogen phosphorylase and glycogen synthase by insulin involving phosphatidylinositol-3 kinase and protein phosphatase-1 in HepG2 cells.
Topics: Androstadienes; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Enzyme Inhibitors; Flavonoids; Glucose; Glycogen; Glycogen Synthase; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Hepatocytes; Humans; Insulin; Marine Toxins; Mitogen-Activated Protein Kinases; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sirolimus; Wortmannin | 2000 |
Multiple signaling pathways in gene expression during sugar starvation. Pharmacological analysis of din gene expression in suspension-cultured cells of Arabidopsis.
Topics: Arabidopsis; Blotting, Northern; Carbohydrates; Cells, Cultured; Cycloheximide; Cytochrome c Group; Darkness; Enzyme Inhibitors; Gene Expression Regulation, Plant; Genes, Plant; Light-Harvesting Protein Complexes; Marine Toxins; Okadaic Acid; Oxazoles; Oxidoreductases; Phosphoprotein Phosphatases; Phosphorylation; Photosynthetic Reaction Center Complex Proteins; Plant Proteins; Protein Kinase Inhibitors; Protein Synthesis Inhibitors; Signal Transduction | 2000 |
Role of protein phosphatase-2A and -1 in the regulation of GSK-3, cdk5 and cdc2 and the phosphorylation of tau in rat forebrain.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinases; CDC2 Protein Kinase; Cyclin-Dependent Kinase 5; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Protein Phosphatase 2; Rats; Rats, Wistar; tau Proteins | 2000 |
3-phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Arabidopsis Proteins; CHO Cells; Cricetinae; Enzyme Inhibitors; Insulin; Kinetics; Marine Toxins; Mutation; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Plant Proteins; Potassium Channels; Protein Serine-Threonine Kinases; Transduction, Genetic | 2001 |
p38MAPK inhibition enhances basal and norepinephrine-stimulated p42/44MAPK phosphorylation in rat pinealocytes.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Gene Expression; Hydroquinones; Imidazoles; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinases; Norepinephrine; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Pineal Gland; Pyridines; Rats; Rats, Sprague-Dawley | 2000 |
A study of the binding requirements of calyculin A and dephosphonocalyculin A with PP1, development of a molecular recognition model for the binding interactions of the okadaic acid class of compounds with PP1.
Topics: Crystallography, X-Ray; Dopamine and cAMP-Regulated Phosphoprotein 32; Enzyme Inhibitors; Hydrogen Bonding; Marine Toxins; Microcystins; Models, Molecular; Mutagenesis, Site-Directed; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphoproteins; Protein Binding | 2001 |
Comparison of F ratios generated from interphase and metaphase chromosome damage induced by high doses of low- and high-LET radiation.
Topics: Chromosome Aberrations; Chromosomes, Human; Dose-Response Relationship, Radiation; G2 Phase; Humans; In Situ Hybridization, Fluorescence; Linear Energy Transfer; Lymphocytes; Male; Marine Toxins; Metaphase; Oxazoles | 2001 |
Signalling pathways regulating the dephosphorylation of Ser729 in the hydrophobic domain of protein kinase Cepsilon upon cell passage.
Topics: 3T3 Cells; Alkaloids; Animals; Anti-Bacterial Agents; Benzophenanthridines; Blotting, Western; Calcineurin; Cell Adhesion; Cell Line; Culture Media; Cyclosporine; Down-Regulation; Enzyme Inhibitors; Flavonoids; Indoles; Isoenzymes; MAP Kinase Signaling System; Marine Toxins; Methionine; Mice; Models, Biological; Okadaic Acid; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Precipitin Tests; Protein Binding; Protein Kinase C; Protein Kinase C-epsilon; Protein Structure, Tertiary; Serine; Signal Transduction; Sirolimus; Tacrolimus; Transfection | 2001 |
Concentration-dependent effects of protein phosphatase (PP) inhibitors implicate PP1 and PP2A in different stages of memory formation.
Topics: Animals; Avoidance Learning; Chickens; Enzyme Inhibitors; Marine Toxins; Memory; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Synapses; Time Factors | 2001 |
Calyculin A inhibits expression of CD8alpha but not CD4 in human peripheral blood T cells.
Topics: Blotting, Western; CD4 Antigens; CD8 Antigens; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation; Humans; Leukocytes, Mononuclear; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; T-Lymphocytes; Time Factors; Transcription, Genetic | 2000 |
Sarcolemmal blebs and osmotic fragility as correlates of irreversible ischemic injury in preconditioned isolated rabbit cardiomyocytes.
Topics: Animals; Cell Membrane Permeability; Cell Survival; Cells, Cultured; Enzyme Inhibitors; Heart; Hypotonic Solutions; Ischemic Preconditioning; Marine Toxins; Microscopy, Electron; Myocardial Ischemia; Myocardium; Osmotic Fragility; Oxazoles; Phosphoprotein Phosphatases; Rabbits; Sarcolemma; Time Factors; Trypan Blue | 2001 |
Protein phosphatase 2A isotypes regulate cell surface expression of the T cell receptor.
Topics: Amino Acid Sequence; Antifungal Agents; CD3 Complex; Down-Regulation; Endocytosis; Enzyme Inhibitors; Exocytosis; Humans; Isoenzymes; Jurkat Cells; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Pyrans; Receptors, Antigen, T-Cell; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Transferrin; Spiro Compounds | 2001 |
Serotonin activates S6 kinase in a rapamycin-sensitive manner in Aplysia synaptosomes.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Anti-Bacterial Agents; Aplysia; Binding Sites; Cell Line; Enzyme Inhibitors; Long-Term Potentiation; Marine Toxins; Molecular Sequence Data; Neuronal Plasticity; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Serine-Threonine Kinases; Ribosomal Protein S6; Ribosomal Protein S6 Kinases; Ribosomal Proteins; Serotonin; Sirolimus; Spodoptera; Synapses; Synaptosomes; Threonine | 2001 |
Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells.
Topics: Androstadienes; Blotting, Western; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol Phosphates; Phosphatidylinositols; Phosphoric Monoester Hydrolases; Phosphorylation; Precipitin Tests; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; Serine; Sphingosine; Threonine; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Proteins; Wortmannin | 2001 |
Inhibition of PP-2A upregulates CaMKII in rat forebrain and induces hyperphosphorylation of tau at Ser 262/356.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Enzyme Inhibitors; Female; Ionophores; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Prosencephalon; Rats; Rats, Wistar; Serine; tau Proteins; Threonine; Time Factors; Up-Regulation | 2001 |
Changes in the activities of protein phosphatase type 1 and type 2A in sea urchin embryos during early development.
Topics: Aniline Compounds; Animals; Blastocyst; Egg Proteins; Embryo, Nonmammalian; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Morula; Okadaic Acid; Oocytes; Organophosphorus Compounds; Oxazoles; Phosphoprotein Phosphatases; Sea Urchins; Zygote | 2000 |
Enteropathogenic Escherichia coli dephosphorylates and dissociates occludin from intestinal epithelial tight junctions.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Escherichia coli; Fluorescent Antibody Technique; Gene Deletion; Gentamicins; Humans; Immunoblotting; Intestinal Mucosa; Marine Toxins; Membrane Proteins; Occludin; Oxazoles; Phosphorylation; Tight Junctions; Time Factors; Transformation, Bacterial; Tumor Cells, Cultured; Virulence | 2000 |
Dose--response of initial G2-chromatid breaks induced in normal human fibroblasts by heavy ions.
Topics: Azure Stains; Carbon; Cells, Cultured; Chromatids; DNA Damage; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Fibroblasts; G2 Phase; Gamma Rays; Humans; Ions; Iron; Marine Toxins; Oxazoles; Silicon | 2001 |
High- and low-LET induced chromosome damage in human lymphocytes: a time-course of aberrations in metaphase and interphase.
Topics: Bisbenzimidazole; Cells, Cultured; DNA Damage; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Fluorescent Dyes; Gamma Rays; Humans; In Situ Hybridization, Fluorescence; Interphase; Iron; Lymphocytes; Male; Marine Toxins; Metaphase; Neon; Oxazoles; Time Factors | 2001 |
Down-regulation of Na-K-Cl cotransport by protein kinase C is mediated by protein phosphatase 1 in pigmented ciliary epithelial cells.
Topics: Carcinogens; Cells, Cultured; Chloride Channels; Ciliary Body; Down-Regulation; Enzyme Inhibitors; Humans; Indoles; Maleimides; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pigment Epithelium of Eye; Potassium Channels; Protein Kinase C; Protein Phosphatase 1; Rubidium Radioisotopes; Sodium Channels; Staurosporine; Tetradecanoylphorbol Acetate | 2001 |
Calyculin-A, an inhibitor for protein phosphatases, induces cortical contraction in unfertilized sea urchin eggs.
Topics: Actins; Animals; Cell Division; Cell Size; Cytochalasin B; Diacetyl; Enzyme Inhibitors; Marine Toxins; Microscopy, Immunoelectron; Myosins; Ovum; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorus Radioisotopes; Phosphorylation; Sea Urchins; Stress, Mechanical | 2001 |
An examination of the secretion-like coupling model for the activation of the Ca2+ release-activated Ca2+ current I(CRAC) in RBL-1 cells.
Topics: Animals; Basophils; Boron Compounds; Caffeine; Calcium; Calcium Channels; Calcium Signaling; Cell Line; Cell Size; Cytochalasin D; Cytoskeleton; Depsipeptides; Enzyme Inhibitors; Heparin; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Lithium; Marine Toxins; Microscopy, Fluorescence; Nocodazole; Oxazoles; Patch-Clamp Techniques; Peptides, Cyclic; Rats; Receptors, Cytoplasmic and Nuclear; Thapsigargin; Time Factors | 2001 |
Evidence that Fas-induced apoptosis leads to S phase arrest.
Topics: Apoptosis; CDC2-CDC28 Kinases; Cell Cycle; Cell Division; Cyclin-Dependent Kinase 2; Cyclin-Dependent Kinases; DNA Fragmentation; Enzyme Inhibitors; fas Receptor; Humans; Jurkat Cells; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Poly(ADP-ribose) Polymerases; Protein Serine-Threonine Kinases; Purines; Roscovitine; S Phase | 2001 |
Gamma-aminobutyric acid type A receptors modulate cAMP-mediated long-term potentiation and long-term depression at monosynaptic CA3-CA1 synapses.
Topics: Animals; Anisomycin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; Long-Term Potentiation; Marine Toxins; Organ Culture Techniques; Oxazoles; Phosphoprotein Phosphatases; Picrotoxin; Protein Biosynthesis; Rats; Receptors, GABA-A; Synapses; Synaptic Transmission; Thionucleotides | 2001 |
Abscisic acid-induced actin reorganization in guard cells of dayflower is mediated by cytosolic calcium levels and by protein kinase and protein phosphatase activities.
Topics: Abscisic Acid; Actins; Calcium; Calcium Chloride; Cytosol; Enzyme Inhibitors; Kinetics; Magnoliopsida; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Plant Growth Regulators; Protein Kinases; Staurosporine | 2001 |
Signal transduction in eclosion hormone-induced secretion of ecdysis-triggering hormone.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cyclic GMP; Egtazic Acid; Insect Hormones; Manduca; Marine Toxins; Oxazoles; Signal Transduction; Staurosporine; Thapsigargin | 2001 |
Lovastatin blocks basic fibroblast growth factor-induced mitogen-activated protein kinase signaling in coronary smooth muscle cells via phosphatase inhibition.
Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fibroblast Growth Factor 2; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; MAP Kinase Signaling System; Marine Toxins; Mevalonic Acid; Muscle, Smooth; Myocardium; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Polyisoprenyl Phosphates; Protein Isoforms; Protein Kinase C; Protein Prenylation; ras Proteins; Time Factors | 2001 |
Involvement of K(+)-Cl(-)-cotransport in the apoptosis induced by N-ethylmaleimide in HepG2 human hepatoblastoma cells.
Topics: Apoptosis; Carcinoma, Hepatocellular; Carrier Proteins; Chlorides; Ethylmaleimide; Flow Cytometry; Genistein; Humans; Ion Transport; K Cl- Cotransporters; Marine Toxins; Oxazoles; Potassium; Symporters; Tumor Cells, Cultured | 2001 |
Phosphorylation of the activation loop of gamma p21-activated kinase (gamma-Pak) and related kinases (MSTs) in normal and stressed neutrophils.
Topics: Androstadienes; Animals; Antibody Specificity; Antigen-Antibody Reactions; Enzyme Activation; Guinea Pigs; Immune Sera; Kinetics; Marine Toxins; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Osmolar Concentration; Oxazoles; Oxidative Stress; p21-Activated Kinases; Peptide Fragments; Phosphopeptides; Phosphorylation; Protein Serine-Threonine Kinases; Rabbits; Tetradecanoylphorbol Acetate; Wortmannin | 2001 |
Rigidity of circulating lymphocytes is primarily conferred by vimentin intermediate filaments.
Topics: Animals; Blood Circulation; Cell Membrane; Cell Movement; Cell Nucleus; Cell Polarity; Cell Separation; Cell Size; Cells, Cultured; Humans; Intermediate Filaments; Interphase; Marine Toxins; Mice; Mice, Inbred Strains; Mice, Knockout; Oxazoles; Stress, Mechanical; T-Lymphocytes; Vimentin | 2001 |
Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3T3 Cells; Animals; Bombesin; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Crk-Associated Substrate Protein; Cytochalasin D; Cytoskeletal Proteins; Cytoskeleton; Dose-Response Relationship, Drug; Enzyme Inhibitors; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Immunoblotting; Indoles; Maleimides; Marine Toxins; Mice; Microscopy, Fluorescence; Myosin-Light-Chain Phosphatase; Nucleic Acid Synthesis Inhibitors; Oxazoles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Kinase C; Protein-Tyrosine Kinases; Proteins; Retinoblastoma-Like Protein p130; Thiazoles; Thiazolidines; Time Factors | 2001 |
K(+) transport in red blood cells from human umbilical cord.
Topics: Acetates; Biological Transport; Bumetanide; Carrier Proteins; Chlorides; Erythrocyte Membrane; Erythrocytes; Ethylmaleimide; Female; Fetal Blood; Fetal Hemoglobin; Fetus; Humans; Indenes; Infant, Newborn; K Cl- Cotransporters; Kinetics; Labor, Obstetric; Marine Toxins; Ouabain; Oxazoles; Oxygen; Potassium; Pregnancy; Sodium-Potassium-Exchanging ATPase; Staurosporine; Symporters; Urea | 2001 |
Allocyclic X chromosome visualized by drug-induced premature chromosome condensation.
Topics: Chromosome Painting; Dosage Compensation, Genetic; Female; Humans; Lymphocytes; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Staining and Labeling; X Chromosome | 1999 |
Serine/threonine phosphatase inhibitors decrease adrenergic arylalkylamine n-acetyltransferase induction in the rat pineal gland.
Topics: Animals; Arylamine N-Acetyltransferase; Cyclic AMP Response Element Modulator; DNA-Binding Proteins; Enzyme Induction; Fos-Related Antigen-2; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pineal Gland; Rats; Rats, Sprague-Dawley; Repressor Proteins; RNA, Messenger; Transcription Factors | 2001 |
Role of cyclic adenosine 3',5'-monophosphate and serum albumin in head-to-head agglutination of boar spermatozoa.
Topics: 1-Methyl-3-isobutylxanthine; Animals; beta-Cyclodextrins; Bucladesine; Cells, Cultured; Culture Media; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclodextrins; Enzyme Inhibitors; Glycoproteins; Isoquinolines; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Serum Albumin; Signal Transduction; Sperm Agglutination; Sperm Capacitation; Sperm Motility; Spermatozoa; Sulfonamides; Swine; Thionucleotides | 2000 |
Stabilization of cortical actin induces internalization of transient receptor potential 3 (Trp3)-associated caveolar Ca2+ signaling complex and loss of Ca2+ influx without disruption of Trp3-inositol trisphosphate receptor association.
Topics: Actins; Calcium; Calcium Channels; Calcium Signaling; Calcium-Transporting ATPases; Caveolae; Caveolin 1; Caveolins; Cells, Cultured; Cytoskeleton; Humans; Inositol 1,4,5-Trisphosphate Receptors; Marine Toxins; Oxazoles; Potassium Iodide; Receptors, Cytoplasmic and Nuclear; Sarcoplasmic Reticulum Calcium-Transporting ATPases; TRPC Cation Channels; Type C Phospholipases | 2001 |
Phosphorylation of histones triggers DNA fragmentation in thymocyte undergoing apoptosis induced by protein phosphatase inhibitors.
Topics: Animals; Apoptosis; Cell Nucleus; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxyribonucleases; DNA Fragmentation; Enzyme Inhibitors; Histones; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Thymus Gland | 2001 |
PP1 inhibitors depolarize Hermissenda photoreceptors and reduce K+ currents.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cantharidin; Chromosomal Proteins, Non-Histone; Conditioning, Psychological; Cyclosporine; DNA-Binding Proteins; Enzyme Inhibitors; Histone Chaperones; Marine Toxins; Membrane Potentials; Mollusca; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Photoreceptor Cells, Invertebrate; Potassium; Potassium Channels; Protein Kinase C; Proteins; Transcription Factors | 2001 |
Culture methods for turtle lymphocytes.
Topics: Animals; Apoptosis; Cell Culture Techniques; Cell Division; Cells, Cultured; Chromosomes; Culture Media; Interleukin-2; Lipopolysaccharides; Lymphocytes; Marine Toxins; Mitosis; Oxazoles; Phytohemagglutinins; Time Factors; Turtles | 2000 |
G2-chromosome aberrations induced by high-LET radiations.
Topics: Cell Line; Cells, Cultured; Chromatids; Chromosome Aberrations; Chromosomes; DNA Damage; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Fibroblasts; G2 Phase; Gamma Rays; Heavy Ions; Humans; Linear Energy Transfer; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Relative Biological Effectiveness | 2001 |
Activation of phosphodiesterase 5 and inhibition of guanylate cyclase by cGMP-dependent protein kinase in smooth muscle.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Alkaloids; Allosteric Site; Animals; Blotting, Western; Carbazoles; Cattle; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 5; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Guanylate Cyclase; Indoles; Intestine, Small; Marine Toxins; Models, Biological; Muscle, Smooth; Nitroprusside; Oxazoles; Phosphoric Diester Hydrolases; Phosphorylation; Precipitin Tests; Protein Structure, Tertiary; Rabbits; Radioimmunoassay | 2001 |
Role of reactive oxygen species generated by NADPH oxidase in the mechanism of activation of K(+)-Cl(-)-cotransport by N-ethylmaleimide in HepG2 human hepatoma cells.
Topics: Carcinoma, Hepatocellular; Chlorides; Enzyme Inhibitors; Ethylmaleimide; Genistein; Humans; K Cl- Cotransporters; Liver Neoplasms; Marine Toxins; NADPH Oxidases; Oxazoles; Potassium; Reactive Oxygen Species; Symporters; Tumor Cells, Cultured | 2001 |
Regulation of immunoglobulin E-mediated secretion by protein phosphatases in human basophils and mast cells of skin and lung.
Topics: Alkenes; Antifungal Agents; Basophils; Enzyme Inhibitors; Histamine Release; Humans; Immunoglobulin E; Lung; Marine Toxins; Mast Cells; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Polyenes; Pyrans; Pyrones; Skin; Spiro Compounds | 2001 |
Centrosome cohesion is regulated by a balance of kinase and phosphatase activities.
Topics: Antineoplastic Agents; Aurora Kinases; Cell Cycle; Cell Cycle Proteins; Centrosome; Cyclin-Dependent Kinases; Cyclins; Cytochalasin D; Cytoskeleton; Enzyme Inhibitors; Humans; Marine Toxins; Microtubules; NIMA-Related Kinases; Nocodazole; Nucleic Acid Synthesis Inhibitors; Okadaic Acid; Oxazoles; Paclitaxel; Phosphoprotein Phosphatases; Phosphorylation; Polo-Like Kinase 1; Protein Kinases; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Transfection; Tumor Cells, Cultured; Xenopus Proteins | 2001 |
Amino acid-induced translation of TOP mRNAs is fully dependent on phosphatidylinositol 3-kinase-mediated signaling, is partially inhibited by rapamycin, and is independent of S6K1 and rpS6 phosphorylation.
Topics: Alleles; Amino Acid Motifs; Amino Acids; Antifungal Agents; Base Sequence; Blotting, Western; Cell Line; Cells, Cultured; Enzyme Inhibitors; Genes, Dominant; Humans; Marine Toxins; Models, Biological; Molecular Sequence Data; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Polyribosomes; Precipitin Tests; Protein Biosynthesis; Pyrimidines; Ribosomal Protein S6; Ribosomal Proteins; RNA; RNA, Messenger; Signal Transduction; Sirolimus; Time Factors; Transfection | 2001 |
Vasopressin rapidly increases phosphorylation of UT-A1 urea transporter in rat IMCDs through PKA.
Topics: Animals; Carrier Proteins; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Kidney Concentrating Ability; Kidney Medulla; Kidney Tubules, Collecting; Male; Marine Toxins; Membrane Glycoproteins; Membrane Transport Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Urea; Urea Transporters; Vasoconstrictor Agents; Vasopressins | 2002 |
Dynamics of ankyrin-containing complexes in chicken embryonic erythroid cells: role of phosphorylation.
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Ankyrins; Cell Nucleus; Chick Embryo; Enzyme Inhibitors; Erythroid Precursor Cells; Marine Toxins; Okadaic Acid; Oxazoles; Peptide Mapping; Phosphoprotein Phosphatases; Phosphorylation; Solubility; Spectrin | 2001 |
Modification of store-operated channel coupling and inositol trisphosphate receptor function by 2-aminoethoxydiphenyl borate in DT40 lymphocytes.
Topics: Animals; B-Lymphocytes; Blotting, Western; Boron Compounds; Calcium; Cell Line; Chickens; CHO Cells; Cricetinae; Cytoskeleton; Enzyme Inhibitors; Inositol 1,4,5-Trisphosphate; Marine Toxins; Muscle, Smooth; Oxazoles; Protein Binding; Protein Structure, Tertiary; Time Factors; Type C Phospholipases | 2002 |
Effects of PP1/PP2A inhibitor calyculin A on the E-C coupling cascade in murine ventricular myocytes.
Topics: Animals; Calcium; Calcium Signaling; Enzyme Inhibitors; Heart Ventricles; In Vitro Techniques; Isoproterenol; Kinetics; Male; Marine Toxins; Membrane Potentials; Mice; Myocardial Contraction; Myocardium; Oxazoles; Phosphoprotein Phosphatases; Phosphorylase a; Potassium Channels | 2002 |
Modulation of microglial superoxide production by alpha-tocopherol in vitro: attenuation of p67(phox) translocation by a protein phosphatase-dependent pathway.
Topics: alpha-Tocopherol; Animals; Antioxidants; Cell Membrane; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Marine Toxins; Mice; Microglia; NADH, NADPH Oxidoreductases; NADPH Oxidases; Nerve Tissue Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein Transport; Rats; Respiratory Burst; Staurosporine; Superoxides; Swine | 2001 |
Potentiation of cyclic AMP and cyclic GMP accumulation by p38 mitogen-activated protein kinase (p38MAPK) inhibitors in rat pinealocytes.
Topics: Anacardic Acids; Animals; Cyclic AMP; Cyclic GMP; Enzyme Inhibitors; Interleukin-1; Ionomycin; Isoproterenol; Male; Marine Toxins; Mitogen-Activated Protein Kinases; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoric Diester Hydrolases; Pineal Gland; Rats; Rats, Sprague-Dawley; Salicylates; Tetradecanoylphorbol Acetate | 2001 |
Kinetics of chromatid break repair in G2-human fibroblasts exposed to low- and high-LET radiations.
Topics: Cell Line; Chromatids; Chromosome Aberrations; Chromosome Breakage; Dose-Response Relationship, Radiation; Fibroblasts; G2 Phase; Gamma Rays; Heavy Ions; Humans; Kinetics; Linear Energy Transfer; Marine Toxins; Oxazoles; Relative Biological Effectiveness | 2001 |
Ser-474 is the major target of insulin-mediated phosphorylation of protein kinase B beta in primary rat adipocytes.
Topics: Adipocytes; Animals; Cells, Cultured; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Insulin; Intracellular Membranes; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley | 2002 |
De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1.
Topics: Adenocarcinoma; Alternative Splicing; Base Sequence; bcl-X Protein; Carboxylic Acids; Caspase 9; Caspases; Ceramides; DNA Primers; Enzyme Inhibitors; Fumonisins; Humans; Lung Neoplasms; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Sphingolipids; Tumor Cells, Cultured | 2002 |
Calyculin A sensitive protein phosphatase is required for Bacillus anthracis lethal toxin induced cytotoxicity.
Topics: Animals; Antifungal Agents; Antigens, Bacterial; Bacillus anthracis; Bacterial Toxins; Blotting, Western; Cells, Cultured; Cyclosporine; Enzyme Inhibitors; Genistein; MAP Kinase Kinase Kinase 1; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyrans; Signal Transduction; Sphingosine; Spiro Compounds | 2002 |
Mechanisms involved in the relaxation of bovine aortic endothelial cells.
Topics: Animals; Aorta; Atrial Natriuretic Factor; Calcium; Cattle; Cell Survival; Cells, Cultured; Cyclic GMP-Dependent Protein Kinases; Dibutyryl Cyclic GMP; Drug Antagonism; Endothelium, Vascular; Enzyme Inhibitors; Hydrogen Peroxide; Marine Toxins; Myosin Light Chains; Natriuretic Peptide, C-Type; Nitroprusside; Oxazoles; Phosphorylation; Vasodilation | 2001 |
Effect of protein phosphatase inhibitors on the development of mouse embryos: protein phosphorylation is involved in the E-cadherin distribution in mouse two-cell embryos.
Topics: Animals; Cadherins; Embryo, Mammalian; Embryonic and Fetal Development; Enzyme Inhibitors; Female; Marine Toxins; Mice; Mice, Inbred ICR; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pregnancy; RNA, Messenger | 2002 |
Calcium influx factor from cytochrome P-450 metabolism and secretion-like coupling mechanisms for capacitative calcium entry in corneal endothelial cells.
Topics: 8,11,14-Eicosatrienoic Acid; Adenosine Triphosphate; Animals; beta-Naphthoflavone; Boron Compounds; Brefeldin A; Calcium; Cattle; Cornea; Cytochalasin D; Cytochrome P-450 Enzyme System; Cytoskeleton; Endothelium, Corneal; Enzyme Inhibitors; Marine Toxins; Models, Biological; Oxazoles; Protein Conformation; Strontium; Time Factors | 2002 |
Interdependence of steroidogenesis and shape changes in Y1 adrenocortical cells: studies with inhibitors of phosphoprotein phosphatases.
Topics: Adrenal Cortex; Animals; Cell Size; Colforsin; Cyclic AMP-Dependent Protein Kinases; Cytoskeletal Proteins; Dipeptides; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mice; Oxazoles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Pregnenolone; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Tumor Cells, Cultured; Vanadates | 2002 |
Phosphorylation of the salivary Na(+)-K(+)-2Cl(-) cotransporter.
Topics: Adenosine Triphosphate; Animals; Carbazoles; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Indole Alkaloids; Indoles; Isoproterenol; Isoquinolines; Maleimides; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Parotid Gland; Peptides, Cyclic; Phenols; Phosphorus Radioisotopes; Phosphorylation; Rats; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Staurosporine; Sulfonamides; Sympathomimetics; Vanadates | 2002 |
Glucose release from GLUT2-null hepatocytes: characterization of a major and a minor pathway.
Topics: Animals; Antiporters; Calcium; Carbon Radioisotopes; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Cell Membrane; Cholesterol; Culture Media; Cytochalasin B; Depsipeptides; Endoplasmic Reticulum; Energy Metabolism; Glucose; Glucose Transporter Type 2; Glucose-6-Phosphate; Hepatocytes; Kinetics; Marine Toxins; Mice; Mice, Knockout; Monosaccharide Transport Proteins; Nocodazole; Oxazoles; Peptides, Cyclic; Phloretin; Phosphotransferases; Progesterone; Uncoupling Agents | 2002 |
Bcl-X(L) and calyculin A prevent translocation of Bax to mitochondria during apoptosis.
Topics: Amino Acid Chloromethyl Ketones; Anisomycin; Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Biological Transport; Carrier Proteins; Caspase 8; Caspase 9; Caspases; Cysteine Proteinase Inhibitors; Cytochrome c Group; Cytosol; HL-60 Cells; Humans; Marine Toxins; Mitochondria; Oxazoles; Protein Synthesis Inhibitors; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2 | 2002 |
Overexpression of calreticulin modulates protein kinase B/Akt signaling to promote apoptosis during cardiac differentiation of cardiomyoblast H9c2 cells.
Topics: Androstadienes; Animals; Apoptosis; Blotting, Northern; Calcium; Calcium-Binding Proteins; Calreticulin; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; DNA, Complementary; Down-Regulation; Endoplasmic Reticulum; Enzyme Inhibitors; Genetic Vectors; Immunoblotting; In Situ Nick-End Labeling; Ionophores; Marine Toxins; Microscopy, Fluorescence; Myocardium; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Ribonucleoproteins; Signal Transduction; Time Factors; Transfection; Up-Regulation; Wortmannin | 2002 |
The outwardly rectifying chloride channel in rat peritoneal mast cells is regulated by serine/threonine kinases and phosphatases.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Chloride Channels; Chlorides; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Male; Marine Toxins; Mast Cells; Membrane Potentials; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Peritoneal Cavity; Phosphoric Monoester Hydrolases; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Thionucleotides | 2002 |
Insight into binding of calyculin A to protein phosphatase 1: isolation of hemicalyculin a and chemical transformation of calyculin A.
Topics: Animals; Cell Survival; Chromatography, High Pressure Liquid; Crystallography, X-Ray; Enzyme Inhibitors; Inhibitory Concentration 50; Leukemia P388; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Porifera; Protein Phosphatase 1; Spectrometry, Mass, Fast Atom Bombardment; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Mechanically stimulated TCH3 gene expression in Arabidopsis involves protein phosphorylation and EIN6 downstream of calcium.
Topics: Arabidopsis; Arabidopsis Proteins; Calcium; Calcium-Binding Proteins; Dimethyl Sulfoxide; Gene Expression Regulation, Plant; Marine Toxins; Mutation; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Protein Kinase Inhibitors; Receptors, Cell Surface; Signal Transduction; Staurosporine; Stress, Mechanical | 2002 |
Differential regulation of a novel variant of the alpha(6) integrin, alpha(6p).
Topics: Actins; Antigens, CD; Antigens, Surface; Cells, Cultured; Cytochalasin D; Cytoskeleton; Glycoside Hydrolases; Humans; Integrin alpha6; Integrin beta1; Integrins; Marine Toxins; Okadaic Acid; Oxazoles; Protein Processing, Post-Translational; Tumor Cells, Cultured | 2002 |
Phosphorylation and functional regulation of ClC-2 chloride channels expressed in Xenopus oocytes by M cyclin-dependent protein kinase.
Topics: Animals; Chloride Channels; CLC-2 Chloride Channels; Cyclin-Dependent Kinases; Enzyme Inhibitors; Female; Kinetics; Kinetin; Marine Toxins; Mitosis; Okadaic Acid; Oocytes; Oxazoles; Phosphorylation; Purines; Recombinant Proteins; Xenopus | 2002 |
Calyculin A-induced endothelial cell shape changes are independent of [Ca(2+)](i) elevation and may involve actin polymerization.
Topics: Actins; Calcium; Cations, Divalent; Cell Line; Cell Size; Colchicine; Cytochalasin B; Electrophysiology; Endothelium, Vascular; Enzyme Inhibitors; Marine Toxins; Oxazoles; Polymers; Protein Kinase C; Time Factors | 2002 |
Crystal structure of the complex between calyculin A and the catalytic subunit of protein phosphatase 1.
Topics: Catalytic Domain; Enzyme Inhibitors; Macromolecular Substances; Marine Toxins; Models, Molecular; Molecular Structure; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Structure, Tertiary | 2002 |
Possible interrelationship between changes in F-actin and myosin II, protein phosphorylation, and cell volume regulation in Ehrlich ascites tumor cells.
Topics: Actins; Amides; Animals; Antibodies; Azepines; Carcinoma, Ehrlich Tumor; Cell Size; Enzyme Activation; Isotonic Solutions; Marine Toxins; Mice; Myosin Type II; Naphthalenes; Osmosis; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Isoforms; Protein Serine-Threonine Kinases; Pyridines; Signal Transduction; Sodium-Hydrogen Exchangers; Tumor Cells, Cultured | 2002 |
Reciprocal regulation of calcium dependent and calcium independent cyclic AMP hydrolysis by protein phosphorylation.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Calcium; Cell Fractionation; Cell Line; Corticotropin-Releasing Hormone; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclic Nucleotide Phosphodiesterases, Type 3; Cyclic Nucleotide Phosphodiesterases, Type 4; Enzyme Activation; Enzyme Inhibitors; Humans; Hydrolysis; Isoenzymes; Kidney; Marine Toxins; Mice; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Pituitary Gland, Anterior; Precipitin Tests; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Second Messenger Systems; Thionucleotides | 2002 |
A novel cAMP-stimulated pathway in protein phosphatase 2A activation.
Topics: Animals; Cell Line; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Activators; Enzyme Inhibitors; Escherichia coli; Immunohistochemistry; Marine Toxins; Oxazoles; Peptide Elongation Factor 2; Phosphoprotein Phosphatases; Protein Phosphatase 2; Rats; Retinoblastoma Protein | 2002 |
PP1/PP2A phosphatases inhibitors okadaic acid and calyculin A block ERK5 activation by growth factors and oxidative stress.
Topics: Animals; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; HeLa Cells; Humans; Hydrogen Peroxide; Marine Toxins; Mitogen-Activated Protein Kinase 7; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Okadaic Acid; Oxazoles; Oxidative Stress; PC12 Cells; Phosphoprotein Phosphatases; Protein Kinase C; Rats | 2002 |
Spatiotemporal regulation of moesin phosphorylation and rear release by Rho and serine/threonine phosphatase during neutrophil migration.
Topics: Acute-Phase Proteins; ADP Ribose Transferases; Blood Proteins; Botulinum Toxins; Cell Movement; Chemotaxis; Cytoskeletal Proteins; Enzyme Inhibitors; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Marine Toxins; Membrane Proteins; Microfilament Proteins; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation | 2002 |
Control of p70 ribosomal protein S6 kinase and acetyl-CoA carboxylase by AMP-activated protein kinase and protein phosphatases in isolated hepatocytes.
Topics: Acetyl-CoA Carboxylase; Aminoimidazole Carboxamide; AMP-Activated Protein Kinases; Animals; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Glutamine; Hepatocytes; Male; Marine Toxins; Multienzyme Complexes; Okadaic Acid; Oligomycins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Ribonucleotides; Ribosomal Protein S6 Kinases; Serine; Sirolimus | 2002 |
Premature chromosome condensation and cell separation studies in biopsies from head and neck tumors for radiosensitivity prediction.
Topics: Adenocarcinoma; Carcinoma, Squamous Cell; Cell Cycle; Cell Division; Cell Separation; Chromosome Aberrations; Fibroblasts; Flow Cytometry; Head and Neck Neoplasms; Humans; Marine Toxins; Oxazoles; Radiation Tolerance; Tumor Cells, Cultured | 2002 |
Kinesin-like proteins are involved in postmitotic nuclear migration of the unicellular green alga Micrasterias denticulata.
Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Adenylyl Imidodiphosphate; Blotting, Western; Cell Movement; Cell Nucleus; Chlorophyta; Enzyme Inhibitors; Immunoblotting; Immunohistochemistry; Kinesins; Marine Toxins; Microscopy, Immunoelectron; Microtubules; Mitosis; Oxazoles; Sulfuric Acid Esters; Vanadates | 2002 |
Mechanisms of activation of NHE by cell shrinkage and by calyculin A in Ehrlich ascites tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Size; Culture Media; Hydrogen-Ion Concentration; Hypertonic Solutions; Marine Toxins; Mechanotransduction, Cellular; Osmolar Concentration; Osmotic Pressure; Oxazoles; Protein Isoforms; Protein Kinase C; Sensitivity and Specificity; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Tumor Cells, Cultured | 2002 |
Effects of the phosphatase inhibitors, okadaic acid, ATPgammaS, and calyculin A on the dividing sand dollar egg.
Topics: Actins; Adenosine Triphosphate; Animals; Cell Division; Chromosomes; Cleavage Stage, Ovum; Enzyme Inhibitors; Marine Toxins; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Sea Urchins | 2002 |
Phosphorylation is required for PMA- and cell-cycle-induced degradation of protein kinase Cdelta.
Topics: 3T3 Cells; Animals; Cell Cycle; Down-Regulation; Isoenzymes; Marine Toxins; Mice; Oxazoles; Phosphorylation; Protein Kinase C; Protein Kinase C-delta; S Phase; Tetradecanoylphorbol Acetate; Threonine; Ubiquitin | 2002 |
Characterization of early, chitin-induced gene expression in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Carbazoles; Chitin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Regulation, Plant; Indole Alkaloids; Lectins; Marine Toxins; Mitogen-Activated Protein Kinase Kinases; Okadaic Acid; Oligosaccharides; Oxazoles; Phosphorylation; Plant Proteins; RNA, Messenger; Signal Transduction; Staurosporine; Transcriptional Activation; Zinc Fingers | 2002 |
A mass spectrometry-based proteomic approach for identification of serine/threonine-phosphorylated proteins by enrichment with phospho-specific antibodies: identification of a novel protein, Frigg, as a protein kinase A substrate.
Topics: Amino Acid Sequence; Antibodies; Blotting, Western; Cell Line; Contractile Proteins; Enzyme Inhibitors; Filamins; Humans; Marine Toxins; Microfilament Proteins; Molecular Sequence Data; Oxazoles; Peptide Fragments; Phosphoproteins; Phosphorylation; Phosphoserine; Phosphothreonine; Precipitin Tests; Proteomics; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2002 |
Roles of the cytoskeleton and of protein phosphorylation events in the osmotic stress response in eel intestinal epithelium.
Topics: Actins; Alkaloids; Anguilla; Animals; Azepines; Benzophenanthridines; Bridged Bicyclo Compounds, Heterocyclic; Bumetanide; Cell Size; Colchicine; Cytochalasins; Cytoskeleton; Enzyme Inhibitors; Hypertonic Solutions; Hypotonic Solutions; Intestinal Mucosa; Ion Transport; Isoquinolines; Marine Toxins; Microtubules; Naphthalenes; Osmotic Pressure; Oxazoles; Phenanthridines; Phosphorylation; Protein Serine-Threonine Kinases; Sulfonamides; Thiazoles; Thiazolidines | 2002 |
Phosphatase inhibition leads to activation of IkappaB kinase in murine macrophages.
Topics: Animals; Blotting, Western; Cells, Cultured; DNA; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; I-kappa B Kinase; Luciferases; Macrophages; Marine Toxins; Mice; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Transport; Signal Transduction; Time Factors; Transfection; Tumor Necrosis Factor-alpha | 2002 |
Phosphatase inhibitors increase the open probability of ENaC in A6 cells.
Topics: Animals; Cell Line; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Epithelial Sodium Channels; Ion Channel Gating; Isomerism; Kidney; Marine Toxins; Microcystins; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Protein Phosphatase 2; Sodium Channels | 2002 |
Protein phosphorylation activates the guard cell Ca2+ channel and is a prerequisite for gating by abscisic acid.
Topics: Abscisic Acid; Adenosine Triphosphate; Algorithms; Calcium; Calcium Channels; Cell Membrane; Enzyme Inhibitors; Evoked Potentials; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plant Epidermis; Plant Proteins; Signal Transduction; Vicia | 2002 |
Phorbol ester stimulates a protein kinase C-mediated agatoxin-TK-sensitive calcium permeability pathway in human red blood cells.
Topics: Adult; Agatoxins; Alkaloids; Benzophenanthridines; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels, N-Type; Calcium Signaling; Cell Size; Diglycerides; Dimethyl Sulfoxide; Enzyme Inhibitors; Erythrocytes; Humans; Ion Transport; Ionophores; Marine Toxins; Okadaic Acid; Osmotic Fragility; Oxazoles; Phenanthridines; Phosphoprotein Phosphatases; Protein Kinase C; Spider Venoms; Staurosporine; Tetradecanoylphorbol Acetate | 2002 |
DNA repair in mononuclear cells: role of serine/threonine phosphatases.
Topics: Calcineurin; Calcineurin Inhibitors; Cyclosporine; DNA Repair; Enzyme Inhibitors; Humans; Immunosuppressive Agents; In Vitro Techniques; Kidney Transplantation; Leukocytes, Mononuclear; Marine Toxins; Neoplasms; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Signal Transduction; Tacrolimus; Ultraviolet Rays | 2002 |
Calyculin A and outward K+ channel currents in rat tail artery smooth muscle cells.
Topics: Animals; Electrophysiology; Male; Marine Toxins; Muscle, Smooth, Vascular; Oxazoles; Patch-Clamp Techniques; Potassium Channels; Rats; Rats, Sprague-Dawley; Vasoconstrictor Agents | 2002 |
Reversible protein phosphorylation regulates the dynamic organization of the pollen tube cytoskeleton: effects of calyculin A and okadaic acid.
Topics: Actin Cytoskeleton; Bridged Bicyclo Compounds, Heterocyclic; Cell Differentiation; Cell Polarity; Cytoskeleton; Enzyme Inhibitors; Fertilization; Flowers; Gene Expression Regulation, Plant; Lilium; Marine Toxins; Microtubules; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Thiazoles; Thiazolidines | 2002 |
Protein phosphatase 2A (PP2A) regulates interleukin-4-mediated STAT6 signaling.
Topics: Base Sequence; CD4-Positive T-Lymphocytes; Cell Line; Enzyme Inhibitors; Humans; Interleukin-4; Jurkat Cells; Marine Toxins; Molecular Sequence Data; Oligodeoxyribonucleotides; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Promoter Regions, Genetic; Protein Phosphatase 2; Recombinant Proteins; Signal Transduction; STAT6 Transcription Factor; Staurosporine; Trans-Activators; Transfection | 2003 |
Products of phosphoinositide specific phospholipase C can trigger dephosphorylation of cofilin in chemoattractant stimulated neutrophils.
Topics: Actin Depolymerizing Factors; Animals; Calcimycin; Calmodulin; Carcinogens; Chemotactic Factors; Enzyme Inhibitors; Guinea Pigs; Immunoblotting; Ionophores; Marine Toxins; Microfilament Proteins; Neutrophils; Oxazoles; Phosphoinositide Phospholipase C; Phosphoric Diester Hydrolases; Phosphorylation; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate | 2003 |
Genetic and pharmacological demonstration of a role for cyclic AMP-dependent protein kinase-mediated suppression of protein phosphatases in gating the expression of late LTP.
Topics: Animals; Colforsin; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Female; Hippocampus; Long-Term Potentiation; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Protein Phosphatase 2; Synaptic Transmission | 2002 |
Endothelial contraction and monolayer hyperpermeability are regulated by Src kinase.
Topics: Animals; Benzoquinones; Capillary Permeability; Cattle; Cell Size; Cells, Cultured; Cytoskeletal Proteins; Endothelium, Vascular; Enzyme Inhibitors; Focal Adhesion Protein-Tyrosine Kinases; Lactams, Macrocyclic; Marine Toxins; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Oxazoles; Paxillin; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein-Tyrosine Kinases; Quinones; Rifabutin; src-Family Kinases | 2003 |
Parathyroid hormone receptor recycling: role of receptor dephosphorylation and beta-arrestin.
Topics: Animals; Arrestins; beta-Arrestin 2; beta-Arrestins; Cell Line; Cell Membrane; Down-Regulation; Embryo, Mammalian; Endocytosis; Enzyme Inhibitors; Fluorescent Antibody Technique, Direct; Gene Expression; Green Fluorescent Proteins; Humans; Kidney; Kinetics; Luminescent Proteins; Marine Toxins; Microscopy, Confocal; Mutagenesis, Site-Directed; Okadaic Acid; Opossums; Oxazoles; Parathyroid Hormone; Phosphoprotein Phosphatases; Phosphorylation; Rats; Receptors, Parathyroid Hormone; Recombinant Fusion Proteins; Transfection | 2002 |
Thymocyte apoptosis induced by phosphorylation of histones is associated with the change in chromatin structure to allow easy accessibility of DNase.
Topics: Animals; Apoptosis; Caspase Inhibitors; Chromatin; Circular Dichroism; Cysteine Proteinase Inhibitors; Deoxyribonucleases; Histones; Marine Toxins; Oxazoles; Phosphorylation; Rats; Thymus Gland | 2002 |
Bradykinin receptor modulation in cellular models of aging and Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Blotting, Western; Cell Line; Electrophoresis, Polyacrylamide Gel; Fibroblasts; Humans; Lung; Male; Marine Toxins; Oxazoles; Phorbol Esters; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase C; Receptor, Bradykinin B2; Receptors, Bradykinin; Skin | 2002 |
Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites.
Topics: Animals; Cattle; Cell Line; COS Cells; Enzyme Activation; Enzyme Inhibitors; Marine Toxins; Mutagenesis, Site-Directed; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Okadaic Acid; Oxazoles; Phosphates; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Protein Phosphatase 2; Serine; Signal Transduction; Threonine; Transfection | 2002 |
Cellular regulation of sodium-calcium exchange.
Topics: Animals; Axons; Calcium; Calcium Channels; CHO Cells; Cricetinae; Cytosol; Decapodiformes; Depsipeptides; Heart; Marine Toxins; Mitochondria; Mutagenesis, Site-Directed; Myocardial Contraction; Oxazoles; Peptides, Cyclic; Recombinant Proteins; Sodium; Sodium Channels; Sodium-Calcium Exchanger; Sphingosine; Transfection | 2002 |
GEA3162 stimulates Ca2+ entry in neutrophils.
Topics: Adenylyl Cyclase Inhibitors; Animals; Barium; Boron Compounds; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Cell Membrane Permeability; Dose-Response Relationship, Drug; Enzyme Inhibitors; Genistein; Imines; Indoles; Manganese; Marine Toxins; Neutrophils; Nitric Oxide Donors; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; S-Nitrosothiols; Strontium; Triazoles | 2003 |
Protein serine/threonine phosphatase 2A activity is inhibited by cAMP in MA-10 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Cantharidin; Cell Line; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Leydig Cells; Male; Marine Toxins; Methionine; Mice; Oxazoles; Phosphoprotein Phosphatases; Protein Biosynthesis; Protein Phosphatase 2 | 2002 |
Growth arrest and DNA damage-inducible protein GADD34 targets protein phosphatase 1 alpha to the endoplasmic reticulum and promotes dephosphorylation of the alpha subunit of eukaryotic translation initiation factor 2.
Topics: Amino Acid Sequence; Animals; Antigens, Differentiation; Binding Sites; Cell Cycle Proteins; Cell Division; Cells, Cultured; DNA Damage; Endoplasmic Reticulum; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Humans; Marine Toxins; Molecular Sequence Data; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Subunits; Proteins; Recombinant Proteins; Serine; Thapsigargin; Tunicamycin | 2003 |
Interleukin-1beta inhibits ATP-induced protein kinase B activation in renal mesangial cells by two different mechanisms: the involvement of nitric oxide and ceramide.
Topics: Adenosine Triphosphate; Animals; Blotting, Western; Cells, Cultured; Ceramides; Dose-Response Relationship, Drug; Enzyme Activation; Enzyme Induction; Enzyme Inhibitors; Glomerular Mesangium; Interleukin-1; Marine Toxins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Okadaic Acid; Oxazoles; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats | 2003 |
Protein phosphatases mediate depotentiation induced by high-intensity theta-burst stimulation.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Animals; Calcineurin; Calcineurin Inhibitors; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enzyme Inhibitors; Hippocampus; Male; Marine Toxins; Membrane Potentials; Okadaic Acid; Organ Culture Techniques; Oxazoles; Phosphodiesterase Inhibitors; Phosphoprotein Phosphatases; Rats; Rats, Sprague-Dawley; Theta Rhythm; Xanthines | 2003 |
Calyculin A-induced actin phosphorylation and depolymerization in renal epithelial cells.
Topics: Actin Cytoskeleton; Adenosine Triphosphate; Animals; Cell Line; Enzyme Inhibitors; Epithelial Cells; Kidney Tubules, Proximal; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Polymers; Protein Serine-Threonine Kinases; Serine; Staurosporine | 2003 |
Ischemia-induced dephosphorylation of cardiomyocyte connexin-43 is reduced by okadaic acid and calyculin A but not fostriecin.
Topics: Alkenes; Animals; Blotting, Western; Cells, Cultured; Connexin 43; Gap Junctions; Gene Expression; Ischemia; Marine Toxins; Myocytes, Cardiac; Okadaic Acid; Oxazoles; Phosphorylation; Polyenes; Pyrones; Rats; Rats, Sprague-Dawley | 2003 |
Oxidative stress induces protein phosphatase 2A-dependent dephosphorylation of the pocket proteins pRb, p107, and p130.
Topics: Antigens, Polyomavirus Transforming; Cells, Cultured; Cyclin-Dependent Kinases; Cyclins; DNA; Enzyme Inhibitors; Gene Expression; Humans; Hydrogen Peroxide; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Oxidative Stress; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 2; Proteins; Retinoblastoma Protein; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; S Phase; Transfection; Umbilical Veins | 2003 |
Functional significance of cannabinoid-mediated, depolarization-induced suppression of inhibition (DSI) in the hippocampus.
Topics: Action Potentials; Animals; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Colforsin; Electric Stimulation; Enzyme Activators; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hippocampus; Interneurons; Lidocaine; Male; Marine Toxins; Morpholines; Naphthalenes; Neural Inhibition; omega-Conotoxin GVIA; Oxazoles; Patch-Clamp Techniques; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, GABA-A; Sodium Channel Blockers | 2003 |
Effects of serine/threonine protein phosphatase inhibitors on morphine-induced antinociception in the tail flick test in mice.
Topics: Analgesics, Opioid; Animals; Binding, Competitive; Cantharidin; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Injections, Intraventricular; Marine Toxins; Mice; Morphine; Naloxone; Nociceptors; Okadaic Acid; Oxazoles; Pain; Pain Measurement; Phosphoprotein Phosphatases; Prosencephalon; Synaptosomes; Tritium | 2003 |
[The relationship between ATM gene silence inducing apoptosis susceptibility and abnormal CDK activity].
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Blotting, Western; CDC2 Protein Kinase; cdc25 Phosphatases; Cell Cycle Proteins; Cyclin-Dependent Kinases; Cycloheximide; DNA-Binding Proteins; Enzyme Inhibitors; Gene Silencing; Humans; Marine Toxins; Nuclear Proteins; Oxazoles; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Protein Synthesis Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Tumor Suppressor Proteins; U937 Cells | 2003 |
[Effects of actin cytoskeleton rearrangements on channel activation by calcium entry into A431 cells].
Topics: Actins; Calcium; Calcium Channel Agonists; Calcium Channels; Calcium Signaling; Carcinoma, Squamous Cell; Cell Line; Cell Membrane; Cytochalasin D; Cytoskeleton; Electric Conductivity; Extracellular Space; Humans; Inositol 1,4,5-Trisphosphate; Ion Channel Gating; Marine Toxins; Oxazoles; Patch-Clamp Techniques; Thapsigargin; Tumor Cells, Cultured | 2003 |
Inhibition of protein phosphatase 2A- and protein phosphatase 1-induced tau hyperphosphorylation and impairment of spatial memory retention in rats.
Topics: Animals; Antibodies; Avoidance Learning; Behavior, Animal; Blotting, Western; Enzyme Inhibitors; Hippocampus; Immunohistochemistry; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Spatial Behavior; Swimming; tau Proteins; Time Factors | 2003 |
Molecular cloning of NHE1 from winter flounder RBCs: activation by osmotic shrinkage, cAMP, and calyculin A.
Topics: Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Base Sequence; Cell Membrane; Cell Size; Chlorides; Cloning, Molecular; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Flounder; Humans; Isoproterenol; Marine Toxins; Molecular Sequence Data; Osmolar Concentration; Oxazoles; Phylogeny; Potassium; Sodium; Sodium-Hydrogen Exchangers | 2003 |
PASK (proline-alanine-rich STE20-related kinase), a regulatory kinase of the Na-K-Cl cotransporter (NKCC1).
Topics: Animals; Blotting, Western; Cell Line; DNA, Complementary; Dose-Response Relationship, Drug; Genes, Dominant; Genetic Vectors; Humans; Marine Toxins; Oxazoles; Oxidative Stress; Phosphorylation; Precipitin Tests; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Rats; Rubidium; Sharks; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Threonine; Time Factors | 2003 |
Activation of Mst1 causes dilated cardiomyopathy by stimulating apoptosis without compensatory ventricular myocyte hypertrophy.
Topics: Alkaloids; Animals; Apoptosis; Benzophenanthridines; Cardiomegaly; Cardiomyopathy, Dilated; Caspase 3; Caspases; Cells, Cultured; Enzyme Activation; Enzyme Inhibitors; Genes, Dominant; Heart Ventricles; Marine Toxins; Mice; Mice, Transgenic; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Organ Specificity; Oxazoles; Phenanthridines; Protein Serine-Threonine Kinases; Rats; Rats, Wistar; Transduction, Genetic | 2003 |
Activation of Na+/H+ exchange by protein phosphatase inhibitors in red blood cells of the frog Rana ridibunda.
Topics: Animals; Biological Transport, Active; Cantharidin; Erythrocytes; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Rana ridibunda; Sodium; Sodium Fluoride; Sodium Radioisotopes | 2003 |
Activation of deoxycytidine kinase by gamma-irradiation and inactivation by hyperosmotic shock in human lymphocytes.
Topics: Comet Assay; Deoxycytidine Kinase; Deoxyribonucleosides; DNA Repair; Enzyme Activation; Gamma Rays; Humans; In Vitro Techniques; Lymphocytes; Marine Toxins; Osmolar Concentration; Oxazoles; Radiation | 2003 |
CRHSP-24 phosphorylation is regulated by multiple signaling pathways in pancreatic acinar cells.
Topics: Alkenes; Animals; Binding Sites; Calcineurin Inhibitors; Calcium; Cholecystokinin; Cyclic AMP; Cyclosporine; DNA-Binding Proteins; Enzyme Inhibitors; Marine Toxins; Okadaic Acid; Oxazoles; Pancreas; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Polyenes; Pyrones; Rats; Rats, Sprague-Dawley; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factors | 2003 |
Possible involvement of energy metabolism in the change of cytoplasm organization induced by a protein phosphatase inhibitor, calyculin A, in root hair cells of Limnobium stoloniferum.
Topics: Actins; Bridged Bicyclo Compounds, Heterocyclic; Carbazoles; Cytoplasm; Enzyme Inhibitors; Hydrocharitaceae; Indole Alkaloids; Marine Toxins; Myosins; Oxazoles; Phosphoprotein Phosphatases; Plant Roots; Sodium Nitrite; Thiazoles; Thiazolidines | 2003 |
Calyculin-A inhibits nitrergic relaxations of the mouse anococcygeus.
Topics: Anal Canal; Animals; Male; Marine Toxins; Mice; Muscle Relaxation; Nitrergic Neurons; Oxazoles; Sacrococcygeal Region | 2003 |
Phosphatidic acid induces actin polymerization by activating protein kinases in soybean cells.
Topics: Actin Cytoskeleton; Actins; Cells, Cultured; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Glycine max; Marine Toxins; Naphthalenes; Oxazoles; Phosphatidic Acids; Plant Proteins; Polymers; Protein Kinase Inhibitors; Protein Kinases; Repressor Proteins; Staurosporine | 2003 |
Protein kinase C inhibits the transplasma membrane influx of Ca2+ triggered by 4-aminopyridine in Jurkat T lymphocytes.
Topics: 4-Aminopyridine; Calcium; Cell Membrane; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Fura-2; Humans; Jurkat Cells; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Potassium Channel Blockers; Protein Kinase C | 2003 |
Involvement of intracellular calcium and protein phosphatases in long-term depression of A-fiber-mediated primary afferent neurotransmission.
Topics: Animals; Animals, Newborn; Bicuculline; Calcium; Chelating Agents; Dose-Response Relationship, Radiation; Drug Combinations; Drug Interactions; Egtazic Acid; Electric Impedance; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Extracellular Space; Female; GABA Antagonists; Glycine Agents; In Vitro Techniques; Long-Term Synaptic Depression; Male; Marine Toxins; Nerve Fibers, Myelinated; Neurons, Afferent; Oxazoles; Phosphoprotein Phosphatases; Potassium Acetate; Rats; Rats, Sprague-Dawley; Strychnine; Substantia Gelatinosa; Synaptic Transmission; Time Factors | 2003 |
Protein phosphatases decrease sarcoplasmic reticulum calcium content by stimulating calcium release in cardiac myocytes.
Topics: Animals; Calcium; Calcium Signaling; Enzyme Inhibitors; Ionophores; Male; Marine Toxins; Myocytes, Cardiac; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Rats; Rats, Sprague-Dawley; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum | 2003 |
Hyperphosphorylation of a mitochondrial protein, prohibitin, is induced by calyculin A in a rice lesion-mimic mutant cdr1.
Topics: Amino Acid Sequence; Base Sequence; Cell Death; Conserved Sequence; Genes, Plant; Marine Toxins; Mitochondria; Mitochondrial Proteins; Molecular Sequence Data; Mutation; Oryza; Oxazoles; Phosphorylation; Prohibitins; Proteins; Repressor Proteins; Sequence Alignment | 2003 |
The influence of calyculin A on lymphocytes in vitro.
Topics: Chromosome Banding; Chromosomes; Humans; Karyotyping; Lymphocytes; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases | 2003 |
Dephosphorylation of histone gamma-H2AX during repair of DNA double-strand breaks in mammalian cells and its inhibition by calyculin A.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Bleomycin; Cell Nucleus; Cells, Cultured; Chromatin; Cricetinae; DNA Damage; DNA Repair; DNA-Binding Proteins; Electrophoresis, Gel, Pulsed-Field; Fibroblasts; Green Fluorescent Proteins; Histones; Humans; Immunoblotting; Kinetics; Luminescent Proteins; Marine Toxins; Methyl Methanesulfonate; Microscopy, Fluorescence; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plasmids; Protein Phosphatase 1; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Serine; Time Factors; Tumor Cells, Cultured; Ubiquitin-Protein Ligases | 2003 |
Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
Topics: 14-3-3 Proteins; 3T3 Cells; Animals; Apoptosis; bcl-Associated Death Protein; bcl-X Protein; Binding Sites; Binding, Competitive; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Humans; Marine Toxins; Mice; Mutation; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Protein Phosphatase 2; Proto-Oncogene Proteins c-bcl-2; Tyrosine 3-Monooxygenase | 2003 |
C-type natriuretic peptide induces human colonic myofibroblast relaxation.
Topics: Calcium; Colon; Cyclic GMP; Cytosol; Enzyme Inhibitors; Epithelial Cells; Fibroblasts; Humans; Marine Toxins; Muscle Relaxation; Muscle, Smooth; Myosin Light Chains; Myosin-Light-Chain Kinase; Natriuretic Peptide, C-Type; Oxazoles; Phosphorylation; Signal Transduction | 2004 |
Intracellular transport of calcium from plasma membrane to mitochondria in adrenal H295R cells: implication for steroidogenesis.
Topics: Actins; Adrenal Glands; Angiotensin II; Biological Transport; Calcium; Calcium Channels; Cell Line; Cell Membrane; Cytosol; Electrophysiology; Humans; Intracellular Membranes; Marine Toxins; Mitochondria; Oxazoles; Potassium; Potassium Chloride; Steroids; Tissue Distribution | 2003 |
Calyculin A causes the activation of histone H1 kinase and condensation of chromosomes in unfertilized sea urchin eggs independently of the maturation-promoting factor.
Topics: 4-Butyrolactone; Animals; Carcinogens; CDC2 Protein Kinase; Chromosomes; Cyclin B; DNA; Enzyme Activation; Enzyme Inhibitors; Female; Male; Marine Toxins; Maturation-Promoting Factor; Oocytes; Ovum; Oxazoles; Porifera; Protein Kinase Inhibitors; Protein Kinases; Sea Urchins; Spermatozoa; Starfish; Thymidine | 2003 |
Truly incomplete and complex exchanges in prematurely condensed chromosomes of human fibroblasts exposed in vitro to energetic heavy ions.
Topics: Cell Cycle; Cell Line; Chromosome Aberrations; Chromosomes, Human; Dose-Response Relationship, Radiation; Fibroblasts; Gamma Rays; Gene Frequency; Heavy Ions; Humans; In Situ Hybridization, Fluorescence; Iron; Linear Energy Transfer; Marine Toxins; Oxazoles; Silicon | 2003 |
Force and myosin light chain phosphorylation in dog airway smooth muscle activated in different ways.
Topics: Acetylcholine; Amides; Androstadienes; Animals; Dogs; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; In Vitro Techniques; Isometric Contraction; Marine Toxins; Muscle, Smooth; Myosin Light Chains; Oxazoles; Phosphorylation; Potassium Chloride; Pyridines; Tetany; Trachea; Wortmannin | 2003 |
Type-2A protein phosphatase activity is required to maintain death receptor responsiveness.
Topics: 3T3 Cells; Animals; Apoptosis; Apoptosis Regulatory Proteins; Cell Line; Enzyme Inhibitors; fas Receptor; HeLa Cells; Humans; MAP Kinase Kinase 1; MAP Kinase Signaling System; Marine Toxins; Membrane Glycoproteins; Mice; Mitogen-Activated Protein Kinase Kinases; Oxazoles; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; TNF-Related Apoptosis-Inducing Ligand; Transfection; Tumor Necrosis Factor-alpha; U937 Cells | 2003 |
Actin-based centripetal flow: phosphatase inhibition by calyculin-A alters flow pattern, actin organization, and actomyosin distribution.
Topics: Actins; Actomyosin; Animals; Biological Transport; Cells, Cultured; Cytoskeletal Proteins; Cytoskeleton; Enzyme Inhibitors; Humans; Marine Toxins; Molecular Motor Proteins; Oxazoles; Phosphoprotein Phosphatases; Sea Urchins | 2003 |
A new cytogenetic approach for the evaluation of mutagenic potential of chemicals that induce cell cycle arrest in the G2 phase.
Topics: Bromodeoxyuridine; Carcinogens; Chromosome Aberrations; Chromosomes; G2 Phase; Humans; Lymphocytes; Marine Toxins; Metaphase; Mitosis; Mutagenesis; Oxazoles; Phosphoprotein Phosphatases; Sister Chromatid Exchange | 2003 |
Alpha1-AR-mediated activation of NKCC in rat cardiomyocytes involves ERK-dependent phosphorylation of the cotransporter.
Topics: Animals; Biotransformation; Bumetanide; Cell Separation; Diuretics; Enzyme Inhibitors; Immunoblotting; In Vitro Techniques; Male; Marine Toxins; Mitogen-Activated Protein Kinases; Myocytes, Cardiac; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Rubidium Radioisotopes; Sodium; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1 | 2004 |
Identification of two distinct pathways of protein kinase Calpha down-regulation in intestinal epithelial cells.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Bryostatins; Calpain; Cell Line, Tumor; Cell Membrane; Cells, Cultured; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Epithelial Cells; Intestinal Mucosa; Lactones; Macrolides; Marine Toxins; Microscopy, Fluorescence; Models, Biological; Multienzyme Complexes; Okadaic Acid; Oxazoles; Phosphorylation; Precipitin Tests; Proteasome Endopeptidase Complex; Protein Kinase C; Protein Kinase C-alpha; Rats; Signal Transduction; Subcellular Fractions; Tetradecanoylphorbol Acetate; Time Factors; Ubiquitin | 2004 |
Photolysis of postsynaptic caged Ca2+ can potentiate and depress mossy fiber synaptic responses in rat hippocampal CA3 pyramidal neurons.
Topics: Analysis of Variance; Animals; Animals, Newborn; Anticonvulsants; Benzothiazoles; Calcium; Coumarins; Cyclopropanes; Cyclosporine; Electric Stimulation; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Marine Toxins; Mossy Fibers, Hippocampal; Oxazoles; Patch-Clamp Techniques; Photolysis; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses; Synaptic Transmission | 2004 |
Seasonality of the red blood cell stress response in rainbow trout (Oncorhynchus mykiss).
Topics: Adrenergic beta-Agonists; Analysis of Variance; Animals; Biological Transport, Active; Bucladesine; Colforsin; DNA Primers; Erythrocytes; Gonadal Steroid Hormones; Lactic Acid; Marine Toxins; Oncorhynchus mykiss; Oxazoles; Protein Binding; Receptors, Adrenergic, beta; RNA, Messenger; Seasons; Sodium-Hydrogen Exchangers; Temperature | 2004 |
Regulating the expression of protein phosphatase type 5.
Topics: Animals; Base Sequence; Binding Sites; Conserved Sequence; DNA Primers; Gene Expression Regulation, Enzymologic; Isoenzymes; Mammals; Marine Toxins; Microcystins; Nuclear Proteins; Okadaic Acid; Oligonucleotides, Antisense; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Recombinant Proteins; RNA, Antisense; RNA, Messenger; Transfection | 2003 |
Cytoskeletal reorganization internalizes multiple transient receptor potential channels and blocks calcium entry into human neutrophils.
Topics: Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cation Transport Proteins; Cytoskeleton; Endocytosis; Gene Expression Regulation; Humans; Immunoblotting; Inositol 1,4,5-Trisphosphate Receptors; Ion Channels; Marine Toxins; Neutrophil Activation; Neutrophils; Oxazoles; Protein Isoforms; Receptors, Cytoplasmic and Nuclear; Receptors, G-Protein-Coupled; TRPC Cation Channels; TRPM Cation Channels | 2004 |
Identification of phosphoproteins and their phosphorylation sites in the WEHI-231 B lymphoma cell line.
Topics: Animals; Cell Line; Chromatography, Affinity; Chromatography, Liquid; Enzyme Inhibitors; Lymphoma, B-Cell; Marine Toxins; Mice; Oxazoles; Peptide Fragments; Phosphoproteins; Phosphoric Monoester Hydrolases; Phosphorylation; Phosphoserine; Phosphothreonine; Proteomics; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Protein phosphatase 1 and an opposing protein kinase regulate steady-state L-type Ca2+ current in mouse cardiac myocytes.
Topics: Animals; Biophysical Phenomena; Biophysics; Buffers; Calcium Channels, L-Type; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Electric Conductivity; Enzyme Inhibitors; Homeostasis; Isoenzymes; Male; Marine Toxins; Mice; Mice, Inbred Strains; Myocytes, Cardiac; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Protein Phosphatase 1; Staurosporine; Thionucleotides | 2004 |
14-3-3-affinity purification of over 200 human phosphoproteins reveals new links to regulation of cellular metabolism, proliferation and trafficking.
Topics: 14-3-3 Proteins; Binding, Competitive; Blotting, Western; Cell Division; Chromatography, Affinity; Enzymes; HeLa Cells; Humans; Marine Toxins; Metabolism; Microtubule-Associated Proteins; Oxazoles; Peptide Mapping; Phosphopeptides; Phosphoproteins; Protein Transport; Tyrosine 3-Monooxygenase | 2004 |
Specific in vivo phosphorylation sites determine the assembly dynamics of vimentin intermediate filaments.
Topics: Amino Acid Sequence; Animals; Cell Line; Cricetinae; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Intermediate Filaments; Marine Toxins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxazoles; Peptide Mapping; Phosphorylation; Protein Kinase C; Protein Structure, Tertiary; Serine; Vimentin | 2004 |
Possible involvement of optimally phosphorylated L-plastin in activation of superoxide-generating NADPH oxidase.
Topics: Amino Acid Sequence; Carbazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Indoles; Marine Toxins; Membrane Glycoproteins; Microfilament Proteins; Molecular Sequence Data; Myosin-Light-Chain Kinase; NADPH Oxidases; Neutrophils; Oxazoles; Phosphoproteins; Phosphorylation; Superoxides | 2003 |
Phosphorylation and 14-3-3 binding of Arabidopsis 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.
Topics: 14-3-3 Proteins; AMP-Activated Protein Kinase Kinases; Arabidopsis; Arabidopsis Proteins; Calcium-Binding Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Darkness; Deoxyglucose; Glutathione Transferase; Indole Alkaloids; Light; Marine Toxins; Nitrate Reductase; Nitrate Reductases; Oxazoles; Phosphofructokinase-2; Phosphoprotein Phosphatases; Phosphorylation; Plant Leaves; Plant Proteins; Protease Inhibitors; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Tyrosine 3-Monooxygenase | 2004 |
Involvement of histone H3 (Ser10) phosphorylation in chromosome condensation without Cdc2 kinase and mitogen-activated protein kinase activation in pig oocytes.
Topics: Animals; CDC2 Protein Kinase; Chromosomes; Enzyme Activation; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Histones; Marine Toxins; Models, Biological; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Serine; Sus scrofa | 2004 |
Posttranslational regulation of Drosophila PERIOD protein by protein phosphatase 2A.
Topics: Animals; Blotting, Western; Catalytic Domain; Cell Line; Cell Nucleus; Circadian Rhythm; Dose-Response Relationship, Drug; Drosophila; Drosophila Proteins; Gene Expression Regulation; Immunohistochemistry; Insecta; Marine Toxins; Models, Biological; Models, Genetic; Mutation; Neurons; Nuclear Proteins; Oxazoles; Period Circadian Proteins; Phosphoprotein Phosphatases; Phosphorylation; Precipitin Tests; Protein Phosphatase 2; Protein Processing, Post-Translational; Ribonucleases; RNA; RNA Interference; RNA, Messenger; Transfection | 2004 |
Melatonin protects SH-SY5Y neuroblastoma cells from calyculin A-induced neurofilament impairment and neurotoxicity.
Topics: Cell Survival; Enzyme Inhibitors; Humans; Marine Toxins; Melatonin; Neuroblastoma; Neurofilament Proteins; Neuroprotective Agents; Neurotoxicity Syndromes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Tumor Cells, Cultured | 2004 |
Inositol hexakisphosphate and sulfonylureas regulate beta-cell protein phosphatases.
Topics: Animals; Cell Line, Tumor; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Insulin; Insulin Secretion; Marine Toxins; Muscles; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phytic Acid; Protein Phosphatase 1; Rabbits; Rats; Signal Transduction; Sulfonylurea Compounds | 2004 |
Involvement of the change in chromatin structure in thymocyte apoptosis induced by phosphorylation of histones.
Topics: Apoptosis; Chromatin; DNA Fragmentation; Enzyme Inhibitors; Histones; Humans; Marine Toxins; Models, Biological; Oxazoles; Phosphorylation; T-Lymphocytes | 2003 |
Induction of SULTR1;1 sulfate transporter in Arabidopsis roots involves protein phosphorylation/dephosphorylation circuit for transcriptional regulation.
Topics: Anion Transport Proteins; Arabidopsis; Arabidopsis Proteins; Carrier Proteins; Cycloheximide; Dactinomycin; Gene Expression Regulation, Plant; Green Fluorescent Proteins; Luminescent Proteins; Marine Toxins; Membrane Transport Proteins; Okadaic Acid; Oxazoles; Phosphorylation; Plant Roots; Plants, Genetically Modified; Promoter Regions, Genetic; Recombinant Fusion Proteins; RNA, Messenger; Sulfate Transporters; Sulfur | 2004 |
Enhanced resistance to blast fungus and bacterial blight in transgenic rice constitutively expressing OsSBP, a rice homologue of mammalian selenium-binding proteins.
Topics: Animals; Bacterial Physiological Phenomena; Carrier Proteins; Cell Line; Fungi; Gene Expression; Gene Expression Regulation, Plant; Genetic Vectors; Hydrogen Peroxide; Mammals; Marine Toxins; Oryza; Oxazoles; Phytoalexins; Plant Diseases; Plant Extracts; Plant Leaves; Plant Proteins; Plants, Genetically Modified; Selenium-Binding Proteins; Sesquiterpenes; Terpenes | 2004 |
Simultaneous stretching and contraction of stress fibers in vivo.
Topics: Actinin; Animals; Fibroblasts; Green Fluorescent Proteins; Lysophospholipids; Marine Toxins; Mice; Myosin Light Chains; Myosin Type II; Oxazoles; Phosphorylation; Photobleaching; Stress Fibers; Swiss 3T3 Cells | 2004 |
Regulation of translation elongation and phosphorylation of eEF2 in rat pancreatic acini.
Topics: Animals; Bombesin; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cholecystokinin; Cyclic AMP; Dose-Response Relationship, Drug; Elongation Factor 2 Kinase; Enzyme Inhibitors; Flavonoids; Imidazoles; Marine Toxins; Oxazoles; Pancreas; Peptide Elongation Factor 2; Peptides; Phosphorylation; Protein Biosynthesis; Pyridines; Rats; Signal Transduction; Sirolimus; Time Factors | 2004 |
Phosphorylation of the histone deacetylase 7 modulates its stability and association with 14-3-3 proteins.
Topics: 14-3-3 Proteins; Cell Line; Cell Nucleus; Cysteine Proteinase Inhibitors; Cytoplasm; Enzyme Inhibitors; Histone Deacetylases; Humans; Leupeptins; Marine Toxins; Models, Biological; Mutation; Oxazoles; Peptide Hydrolases; Phosphorylation; Plasmids; Proteasome Endopeptidase Complex; Protein Binding; Protein Biosynthesis; Time Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tyrosine 3-Monooxygenase; Up-Regulation | 2004 |
Simultaneous mapping of filamentous actin flow and turnover in migrating cells by quantitative fluorescent speckle microscopy.
Topics: Actins; Animals; Biopolymers; Cell Movement; Cells, Cultured; Cytoplasmic Structures; Cytoskeleton; Cytotoxins; Depsipeptides; Epithelial Cells; Lung; Marine Toxins; Microscopy, Fluorescence; Oxazoles; Peptides, Cyclic; Perfusion; Pseudopodia; Reproducibility of Results; Salamandridae; Time Factors | 2004 |
Bone morphogenetic proteins and neurotrophins provide complementary protection of septal cholinergic function during phosphatase inhibitor-induced stress.
Topics: Acetylcholinesterase; Animals; bcl-X Protein; Bone Morphogenetic Proteins; Caspase 3; Caspases; Cell Death; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Drug Combinations; Embryo, Mammalian; Enzyme Inhibitors; Fluoresceins; Glial Fibrillary Acidic Protein; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Immunohistochemistry; Marine Toxins; Nerve Growth Factors; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-bcl-2; Rats; Septal Nuclei; Stress, Physiological; tau Proteins; Time Factors; Transfection | 2004 |
Phosphatase inhibition reveals a calcium entry pathway dependent on protein kinase A in thyroid FRTL-5 cells: comparison with store-operated calcium entry.
Topics: Actins; Animals; Calcium; Cyclic AMP-Dependent Protein Kinases; Marine Toxins; Oxazoles; Rats; Thapsigargin; Thyroid Gland | 2004 |
Investigation into the relationship between calyculin A-mediated potentiation of NADPH oxidase activity and inhibition of store-operated uptake of calcium by human neutrophils.
Topics: Adult; Biological Transport; Calcium; Fura-2; Humans; In Vitro Techniques; Manganese; Marine Toxins; Membrane Potentials; NADPH Oxidases; Neutrophils; Oxazoles; Oxygen Consumption; Spectrometry, Fluorescence; Superoxides | 2004 |
Inhibitors of protein phosphatases 1 and 2A differentially prevent intrinsic and extrinsic apoptosis pathways.
Topics: Apoptosis; Burkitt Lymphoma; Cell Line, Tumor; Enzyme Inhibitors; Humans; Jurkat Cells; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Pyrans; Signal Transduction; Spiro Compounds; U937 Cells | 2004 |
Premature chromosome condensation in human resting peripheral blood lymphocytes for chromosome aberration analysis using specific whole-chromosome DNA hybridization probes.
Topics: Chromosome Aberrations; Chromosome Painting; DNA Probes; Humans; Lymphocytes; Marine Toxins; Microscopy, Fluorescence; Okadaic Acid; Oxazoles | 2005 |
Protein phosphorylation in Nicotiana tabacum cells in response to perception of lipopolysaccharides from Burkholderia cepacia.
Topics: Burkholderia cepacia; Cells, Cultured; Lipopolysaccharides; Marine Toxins; Nicotiana; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plant Proteins; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Receptors, Cell Surface; Respiratory Burst; Signal Transduction; Staurosporine | 2004 |
PTEN expression elicited by EGR-1 transcription factor in calyculin A-induced apoptotic cells.
Topics: Apoptosis; Base Sequence; Cell Line, Tumor; DNA Primers; DNA-Binding Proteins; Down-Regulation; Early Growth Response Protein 1; Humans; Immediate-Early Proteins; Marine Toxins; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; PTEN Phosphohydrolase; Transcription Factors; Tumor Suppressor Proteins | 2005 |
Mismatch repair protein Msh2 contributes to UVB-induced cell cycle arrest in epidermal and cultured mouse keratinocytes.
Topics: Animals; Base Pair Mismatch; Bromodeoxyuridine; Cell Cycle; DNA Repair; DNA-Binding Proteins; Flow Cytometry; Keratinocytes; Marine Toxins; Mice; Mice, Mutant Strains; MutS Homolog 2 Protein; Oxazoles; Proto-Oncogene Proteins; Ultraviolet Rays | 2005 |
Calyculin-A disrupts subplasmalemmal junction and recurring Ca2+ waves in vascular smooth muscle.
Topics: Action Potentials; Animals; Calcium; Calcium Signaling; Calcium-Transporting ATPases; Cell Membrane; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Marine Toxins; Microscopy, Electron, Transmission; Muscle Contraction; Muscle, Smooth, Vascular; Organ Culture Techniques; Oxazoles; Phenylephrine; Rabbits; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Vasoconstrictor Agents; Vena Cava, Inferior | 2005 |
Mitochondrial organization and motility probed by two-photon microscopy in cultured mouse brainstem neurons.
Topics: Animals; Biological Transport; Cells, Cultured; Cyclic AMP; Dendrites; Enzyme Inhibitors; Marine Toxins; Mice; Microscopy, Fluorescence; Microtubules; Mitochondria; Neurons; Nocodazole; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Respiratory Center | 2005 |
Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.
Topics: Acyl Coenzyme A; Arachidonic Acid; Catalytic Domain; Crystallography, X-Ray; Enzyme Activation; Enzyme Inhibitors; HSP90 Heat-Shock Proteins; Humans; Marine Toxins; Microcystins; Models, Molecular; Nuclear Proteins; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Conformation; Repetitive Sequences, Nucleic Acid; Signal Transduction | 2005 |
Activation of ferret erythrocyte Na+-K+-2Cl- cotransport by deoxygenation.
Topics: Animals; Arsenites; Erythrocytes; Ferrets; In Vitro Techniques; Magnesium; Marine Toxins; Oxazoles; Oxygen; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Rubidium; Signal Transduction; Sodium Compounds; Sodium-Potassium-Chloride Symporters | 2005 |
The effect of anionic amphiphiles on the recruitment of Rac in neutrophils.
Topics: Androstadienes; Animals; Anions; Arachidonic Acid; Cell Membrane; Cell-Free System; Chromones; Cytosol; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Guanosine Triphosphate; Guinea Pigs; Macromolecular Substances; Marine Toxins; Morpholines; NADPH Oxidases; Neutrophils; Oxazoles; Oxygen; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Sodium Dodecyl Sulfate; Superoxides; Surface-Active Agents; Time Factors; Wortmannin | 2004 |
Role of protein phosphatase 2A in mGluR5-regulated MEK/ERK phosphorylation in neurons.
Topics: Animals; Blotting, Western; Brain; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Glycine; Immunoprecipitation; MAP Kinase Kinase 1; Marine Toxins; Microscopy, Confocal; Microscopy, Fluorescence; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Neurons; Okadaic Acid; Oxazoles; Peptides; Phenylacetates; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Rats; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Resorcinols; Serine; Signal Transduction; Threonine; Time Factors; Up-Regulation | 2005 |
Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys.
Topics: Amides; Animals; Aqueous Humor; Atropine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Macaca fascicularis; Macaca mulatta; Male; Marine Toxins; Oxazoles; Phosphoric Monoester Hydrolases; Pyridines; Rheology; Trabecular Meshwork | 2005 |
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress.
Topics: Animals; Antigens, Differentiation; Apoptosis; Cell Cycle Proteins; Cell Line; Cinnamates; Cytoprotection; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Genes, Reporter; Herpesvirus 1, Human; Keratitis, Herpetic; Male; Marine Toxins; Mice; Oxazoles; PC12 Cells; Phosphoprotein Phosphatases; Phosphorylation; Protein Folding; Protein Kinases; Protein Phosphatase 1; Proteins; Rats; Thiourea; Tunicamycin; Viral Proteins; Virus Replication | 2005 |
Effect of melatonin on calyculin A-induced tau hyperphosphorylation.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3; Malondialdehyde; Marine Toxins; Melatonin; Oxazoles; Oxidative Stress; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; tau Proteins | 2005 |
The usefulness of calyculin a for cytogenetic prenatal diagnosis.
Topics: Amniotic Fluid; Cell Division; Cells, Cultured; Centromere; Chromosome Banding; Chromosome Breakage; Chromosomes, Human; Cytogenetic Analysis; G2 Phase; Humans; Karyotyping; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Prenatal Diagnosis | 2005 |
Casein kinase I in the mammalian circadian clock.
Topics: Alkaline Phosphatase; Animals; Biological Clocks; Casein Kinase 1 epsilon; Cell Cycle Proteins; Cell Line; Humans; Marine Toxins; Mice; Nuclear Proteins; Oxazoles; Period Circadian Proteins; Transcription Factors; Transfection; Xenopus laevis | 2005 |
Magnolol induces the distributional changes of p160 and adipose differentiation-related protein in adrenal cells.
Topics: Adrenal Glands; Animals; Biphenyl Compounds; Blotting, Western; Butadienes; Cells, Cultured; Cytoplasmic Granules; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Female; Flavonoids; Fluorescent Antibody Technique; Histone Acetyltransferases; Lignans; Lipid Metabolism; Marine Toxins; Membrane Proteins; Microscopy, Fluorescence; Nitriles; Nuclear Receptor Coactivator 1; Oxazoles; Perilipin-2; Phosphoprotein Phosphatases; Phosphorylation; Protein Transport; Pyrans; Rats; Rats, Wistar; Spiro Compounds; Time Factors; Transcription Factors | 2005 |
Chromosomal aberrations induced by high-energy iron ions with shielding.
Topics: Aluminum; Cell Cycle; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Humans; Iron; Lead; Linear Energy Transfer; Lymphocytes; Marine Toxins; Oxazoles; Particle Accelerators; Phosphoprotein Phosphatases; Polymethyl Methacrylate; Radiation Protection; Space Flight | 2004 |
The role of calcium desensitization in vascular hyporeactivity and its regulation after hemorrhagic shock in the rat.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; Blood Vessels; Calcium; Carbazoles; Cyclic GMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Indoles; Insulin; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Oxazoles; Perfusion; Protein Kinase Inhibitors; Rats; Rats, Wistar; Shock, Hemorrhagic; Staurosporine; Tetradecanoylphorbol Acetate | 2005 |
Peroxynitrite-induced relaxation in isolated rat aortic rings and mechanisms of action.
Topics: Animals; Aorta; Calcium Chloride; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; In Vitro Techniques; Male; Marine Toxins; Methylene Blue; Oxadiazoles; Oxazoles; Peroxynitrous Acid; Phenylephrine; Piperazines; Potassium; Purines; Quinoxalines; Rats; Rats, Wistar; Sildenafil Citrate; Sulfones; Tetraethylammonium; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2005 |
Regulation of Na-K-2Cl cotransport in cultured bovine corneal endothelial cells.
Topics: Animals; Cattle; Cells, Cultured; Cornea; Cytoskeletal Proteins; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ions; Marine Toxins; Oxazoles; Phosphorylation; Sodium-Potassium-Chloride Symporters | 2005 |
Phospho-pivot modeling predicts specific interactions of protein phosphatase-1 with a phospho-inhibitor protein CPI-17.
Topics: Animals; Binding Sites; Computer Simulation; Marine Toxins; Models, Molecular; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Protein Phosphatase 1; Rabbits; Thermodynamics | 2005 |
Simple biodosimetry method for use in cases of high-dose radiation exposure that scores the chromosome number of Giemsa-stained drug-induced prematurely condensed chromosomes (PCC).
Topics: Adult; Azure Stains; Cell Cycle Proteins; Chromosome Aberrations; Chromosomes; Coloring Agents; Female; Gamma Rays; Humans; Karyotyping; Lymphocytes; Male; Marine Toxins; Middle Aged; Mitogens; Oxazoles; Phytohemagglutinins; Radiation Injuries; Radiometry | 2005 |
PDGF activates K-Cl cotransport through phosphoinositide 3-kinase and protein phosphatase-1 in primary cultures of vascular smooth muscle cells.
Topics: Androstadienes; Animals; Becaplermin; Cells, Cultured; Chlorides; Chromones; Cyclosporine; Flavonoids; K Cl- Cotransporters; Marine Toxins; Mitogen-Activated Protein Kinase Kinases; Morpholines; Muscle, Smooth, Vascular; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Platelet-Derived Growth Factor; Potassium; Protein Phosphatase 1; Proto-Oncogene Proteins c-sis; Rats; Rats, Sprague-Dawley; Symporters; Vanadates; Wortmannin | 2005 |
p38 MAPK regulates phosphorylation of Bad via PP2A-dependent suppression of the MEK1/2-ERK1/2 survival pathway in TNF-alpha induced endothelial apoptosis.
Topics: Alkenes; Apoptosis; bcl-Associated Death Protein; Cell Line; Cell Survival; Cells, Cultured; Down-Regulation; Endothelial Cells; Humans; Imidazoles; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Polyenes; Protein Phosphatase 2; Pyridines; Pyrones; Signal Transduction; Tumor Necrosis Factor-alpha | 2006 |
Regulation of erythrocyte Na-K-2Cl cotransport by threonine phosphorylation.
Topics: Animals; Erythrocytes; Ferrets; Genistein; Magnesium; Marine Toxins; Microcystins; Molecular Weight; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Phosphorylation; Phosphothreonine; Protein Phosphatase 1; Pyrazoles; Pyrimidines; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Staurosporine; Threonine | 2005 |
Akt regulates the subcellular localization of the Rab27a-binding protein JFC1 by phosphorylation.
Topics: Cell Line, Tumor; Chromones; Enzyme Inhibitors; HeLa Cells; Humans; Immunoprecipitation; Interleukin-6; Marine Toxins; Membrane Proteins; Morpholines; Mutagenesis, Site-Directed; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; rab GTP-Binding Proteins; rab27 GTP-Binding Proteins; Recombinant Fusion Proteins; Secretory Vesicles; Transfection; Vesicular Transport Proteins | 2005 |
Regulation of potassium transport in human lens epithelial cells.
Topics: Bumetanide; Cell Line; Diuretics; Enzyme Inhibitors; Epithelial Cells; Ethylmaleimide; Furosemide; Genistein; Humans; Ion Transport; K Cl- Cotransporters; Lens, Crystalline; Marine Toxins; Ouabain; Oxazoles; Phosphoprotein Phosphatases; Potassium; Protein Kinase C; Protein Phosphatase 1; Protein-Tyrosine Kinases; Rubidium; Sodium-Potassium-Chloride Symporters; Sodium-Potassium-Exchanging ATPase; Staurosporine; Symporters | 2006 |
IKKbeta phosphorylates p65 at S468 in transactivaton domain 2.
Topics: Active Transport, Cell Nucleus; Animals; Binding Sites; Blotting, Western; Cell Line; Cell Line, Tumor; Cells, Cultured; DNA Mutational Analysis; Fibroblasts; Genes, Dominant; Genes, Reporter; HeLa Cells; Humans; I-kappa B Kinase; Immunoprecipitation; Inflammation; Interleukin-1; Leukocytes, Mononuclear; Marine Toxins; Mice; Mice, Transgenic; Microscopy, Fluorescence; Mutagenesis, Site-Directed; Mutation; Oxazoles; Phosphorylation; Plasmids; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Transcription Factor RelA; Transcriptional Activation; Transfection; Tumor Necrosis Factor-alpha | 2005 |
Role of protein phosphatases in estrogen-mediated neuroprotection.
Topics: Animals; Calcineurin; Cell Survival; Cells; Cells, Cultured; Enzyme Inhibitors; Estradiol; Estrogens; Glutamic Acid; Marine Toxins; Neurons; Neuroprotective Agents; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Time Factors | 2005 |
Calcium and protein phosphatase 1/2A attenuate N-methyl-D-aspartate receptor activity in the anoxic turtle cortex.
Topics: Animals; Calcium; Calmodulin; Cerebral Cortex; Egtazic Acid; Female; Hypoxia; Imidazoles; Marine Toxins; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoprotein Phosphatases; Protein Phosphatase 1; Pyrethrins; Receptors, N-Methyl-D-Aspartate; Turtles | 2005 |
The involvement of Rho-associated kinases in agonist-dependent contractions of human maternal and placental arteries at term gestation.
Topics: Amides; Arteries; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Female; Humans; Intracellular Signaling Peptides and Proteins; Marine Toxins; Muscle Relaxants, Central; Muscle, Smooth, Vascular; Myometrium; Omentum; Oxazoles; Phosphoprotein Phosphatases; Placenta; Pregnancy; Pregnancy Trimester, Third; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Vasoconstriction | 2005 |
Histone acetylation-independent effect of histone deacetylase inhibitors on Akt through the reshuffling of protein phosphatase 1 complexes.
Topics: Apoptosis; Cell Cycle; Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Down-Regulation; Enzyme Inhibitors; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositols; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Isoforms; Protein Phosphatase 1; Protein Phosphatase 2; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Pyrans; RNA, Small Interfering; Serine; Signal Transduction; Spiro Compounds; Subcellular Fractions; Threonine; Time Factors | 2005 |
Induction and repair of DNA double-strand breaks in human cells: dephosphorylation of histone H2AX and its inhibition by calyculin A.
Topics: DNA Damage; DNA Repair; Electrophoresis, Gel, Pulsed-Field; Histones; Humans; Marine Toxins; Oxazoles; Phosphorylation | 2005 |
Inhibition of neuronal nitric-oxide synthase by phosphorylation at Threonine1296 in NG108-15 neuronal cells.
Topics: Animals; Enzyme Inhibitors; Marine Toxins; Mutation; NADP; Neurons; Nitric Oxide; Nitric Oxide Synthase Type I; Okadaic Acid; Oxazoles; Phosphorylation; Rats; Threonine | 2005 |
Inhibition by calyculin A and okadaic acid of the Ca(2+) release-activated Ca(2+) entry pathway in rat basophilic leukemia cells: evidence for regulation by type 1/2A serine/threonine phosphatase activity.
Topics: Animals; Boron Compounds; Calcium; Calcium Signaling; Cations, Divalent; Cells, Cultured; Enzyme Inhibitors; Ion Transport; Leukemia, Basophilic, Acute; Manganese; Marine Toxins; Membrane Potentials; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Phosphatase 1; Rats; Thapsigargin | 2005 |
Premature condensation induces breaks at the interface of early and late replicating chromosome bands bearing common fragile sites.
Topics: Aphidicolin; Bromodeoxyuridine; Chromosome Banding; Chromosome Breakage; Chromosome Fragile Sites; Chromosomes, Artificial, Bacterial; Chromosomes, Human; DNA Replication; Humans; In Situ Hybridization, Fluorescence; Interphase; Marine Toxins; Oxazoles | 2005 |
Hsp27 enhances recovery of splicing as well as rephosphorylation of SRp38 after heat shock.
Topics: alpha-Crystallin B Chain; Cell Cycle Proteins; Heat-Shock Proteins; HeLa Cells; HSP27 Heat-Shock Proteins; HSP70 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Marine Toxins; Molecular Chaperones; Neoplasm Proteins; Oxazoles; Phosphorylation; Protein Processing, Post-Translational; Repressor Proteins; RNA Splicing; RNA-Binding Proteins; Serine-Arginine Splicing Factors | 2006 |
Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1.
Topics: Actin Cytoskeleton; Actins; Adaptor Proteins, Signal Transducing; Antineoplastic Agents; Cell Adhesion; Cell Line; Colchicine; Cytochalasin D; Enzyme Inhibitors; Humans; Intermediate Filaments; Marine Toxins; Microtubules; Nocodazole; Nucleic Acid Synthesis Inhibitors; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Isoforms; Protein Phosphatase 2; Pyrans; Serine; Signal Transduction; Spiro Compounds; Threonine; Tubulin Modulators | 2006 |
Checkpoint abrogation in G2 compromises repair of chromosomal breaks in ataxia telangiectasia cells.
Topics: Ataxia Telangiectasia; Caffeine; Central Nervous System Stimulants; Chromatin Assembly and Disassembly; Chromosome Breakage; Chromosomes, Human; DNA; DNA Repair; G2 Phase; Humans; Lymphocytes; Marine Toxins; Mitotic Index; Oxazoles; Radiation Tolerance; Tumor Cells, Cultured | 2005 |
Effects of calpain and Rho-kinase inhibitors on the acrosome reaction and motility of fowl spermatozoa in vitro.
Topics: Acrosome Reaction; Acrylates; Adenosine Triphosphate; Amides; Animals; Calcium; Calpain; Cells, Cultured; Chickens; Intracellular Signaling Peptides and Proteins; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sperm Motility; Spermatozoa | 2006 |
Disturbance of endomembrane trafficking by brefeldin A and calyculin A reorganizes the actin cytoskeleton of Lilium longiflorum pollen tubes.
Topics: Actin Cytoskeleton; Actins; Brefeldin A; Bridged Bicyclo Compounds, Heterocyclic; Cell Membrane; Cytochalasin B; Flowers; Lilium; Marine Toxins; Models, Biological; Oxazoles; Phosphatidate Phosphatase; Phosphorylation; Protein Transport; Thiazoles; Thiazolidines | 2005 |
Involvement of reduced sensitivity to Ca in beta-adrenergic action on airway smooth muscle.
Topics: Adrenergic beta-Agonists; Amides; Animals; Asthma; Bucladesine; Calcium; Calcium Channel Blockers; Colforsin; Cyclic AMP Receptor Protein; Cyclic AMP-Dependent Protein Kinases; Depression, Chemical; Fura-2; Guinea Pigs; Imidazoles; In Vitro Techniques; Indoles; Intracellular Signaling Peptides and Proteins; Isoproterenol; Male; Maleimides; Marine Toxins; Methacholine Chloride; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Oxazoles; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Trachea | 2006 |
Novel blockade of protein kinase A-mediated phosphorylation of AMPA receptors.
Topics: 2-Amino-5-phosphonovalerate; Adrenergic beta-Antagonists; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzothiadiazines; Calcineurin Inhibitors; Calcium; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Cyclosporine; Egtazic Acid; Excitatory Amino Acid Antagonists; Glutamic Acid; GTP-Binding Protein alpha Subunits, Gs; Hippocampus; Isoproterenol; Long-Term Potentiation; Male; Marine Toxins; Mice; Mice, Inbred C57BL; N-Methylaspartate; Oxazoles; Phenols; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Piperidines; Protein Phosphatase 1; Protein Phosphatase 2; Protein Processing, Post-Translational; Receptors, Adrenergic, beta-1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction | 2006 |
Hyperphosphorylation of the rotavirus NSP5 protein is independent of serine 67, [corrected] NSP2, or [corrected] the intrinsic insolubility of NSP5 is regulated by cellular phosphatases.
Topics: Amino Acid Substitution; Animals; Artificial Gene Fusion; Cell Fractionation; Cell Line; Chlorocebus aethiops; Enzyme Inhibitors; Genes, Reporter; Green Fluorescent Proteins; Macaca mulatta; Marine Toxins; Mutagenesis, Site-Directed; Mutation; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Structure, Tertiary; RNA-Binding Proteins; Rotavirus; Solubility; Viral Nonstructural Proteins | 2006 |
Caveolae and sarcoplasmic reticular coupling in smooth muscle cells of pressurised arteries: the relevance for Ca2+ oscillations and tone.
Topics: Animals; Anticholesteremic Agents; beta-Cyclodextrins; Calcium; Caveolae; In Vitro Techniques; Marine Toxins; Mesenteric Arteries; Microscopy, Electron; Muscle Contraction; Myocytes, Smooth Muscle; Myography; Oxazoles; Phosphoric Monoester Hydrolases; Rats; Sarcoplasmic Reticulum | 2006 |
Ser-2030, but not Ser-2808, is the major phosphorylation site in cardiac ryanodine receptors responding to protein kinase A activation upon beta-adrenergic stimulation in normal and failing hearts.
Topics: Adrenergic beta-Agonists; Animals; Arrhythmias, Cardiac; Benzylamines; Blotting, Western; Calcium Signaling; Carrier Proteins; Cell Line; Cyclic AMP-Dependent Protein Kinases; Heart Failure; Humans; Ion Channel Gating; Ion Transport; Isoproterenol; Kidney; Marine Toxins; Mice; Myocytes, Cardiac; Oxazoles; Peptide Fragments; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Rabbits; Rats; Recombinant Fusion Proteins; Ryanodine Receptor Calcium Release Channel; Sodium-Calcium Exchanger; Staurosporine; Structure-Activity Relationship; Sulfonamides; Transfection | 2006 |
Protein serine/threonine phosphatase-1 dephosphorylates p53 at Ser-15 and Ser-37 to modulate its transcriptional and apoptotic activities.
Topics: Amino Acid Substitution; Animals; Apoptosis; bcl-2-Associated X Protein; Cell Line; Epithelial Cells; Genes, bcl-2; Genes, p53; Genes, Reporter; Humans; Immunoprecipitation; Lens, Crystalline; Marine Toxins; Mice; Mice, Knockout; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Protein Binding; Protein Interaction Mapping; Protein Phosphatase 1; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-bcl-2; Recombinant Fusion Proteins; RNA Interference; RNA, Small Interfering; Transcription, Genetic; Tumor Suppressor Protein p53 | 2006 |
Sequential phosphorylation of Ser-10 on histone H3 and ser-139 on histone H2AX and ATM activation during premature chromosome condensation: relationship to cell-cycle phase and apoptosis.
Topics: Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Cycle; Cell Cycle Proteins; Chromatin Assembly and Disassembly; DNA Damage; DNA Replication; DNA-Binding Proteins; Enzyme Inhibitors; Flow Cytometry; Histones; HL-60 Cells; Humans; Immunohistochemistry; Marine Toxins; Microscopy, Fluorescence; Oxazoles; Phosphorylation; Point Mutation; Protein Serine-Threonine Kinases; Serine; Tumor Suppressor Proteins | 2006 |
Effect of intracellular magnesium and oxygen tension on K+-Cl- cotransport in normal and sickle human red cells.
Topics: Anemia, Sickle Cell; Antisickling Agents; Dimethyl Adipimidate; Enzyme Inhibitors; Erythrocytes; Erythrocytes, Abnormal; Ethylmaleimide; Humans; K Cl- Cotransporters; Magnesium; Manometry; Marine Toxins; Oxazoles; Oxygen; Symporters | 2006 |
Calyculin and okadaic acid promote perilipin phosphorylation and increase lipolysis in primary rat adipocytes.
Topics: Adipocytes; Animals; Carrier Proteins; Cells, Cultured; Enzyme Inhibitors; Kinetics; Lipolysis; Marine Toxins; Okadaic Acid; Oxazoles; Perilipin-1; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Rats; Sterol Esterase | 2006 |
Protein phosphatase 1, a Plasmodium falciparum essential enzyme, is exported to the host cell and implicated in the release of infectious merozoites.
Topics: Amino Acid Sequence; Animals; Carrier Proteins; Cell Membrane; Erythrocytes; Golgi Apparatus; In Vitro Techniques; Marine Toxins; Membrane Proteins; Molecular Sequence Data; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Plasmodium falciparum; Protein Phosphatase 1; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protozoan Proteins | 2006 |
Propofol inhibits phosphorylation of N-methyl-D-aspartate receptor NR1 subunits in neurons.
Topics: Animals; Calcium; Marine Toxins; Neurons; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Propofol; Protein Phosphatase 2; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Serine; Tyrosine | 2006 |
Possibility of a non-amino acid pathway in the biosynthesis of marine-derived oxazoles.
Topics: Amino Acids; Bacteria; Eukaryota; Marine Toxins; Molecular Structure; Oxazoles | 2006 |
Regulation of acrosome reaction of fowl spermatozoa: evidence for the involvement of protein kinase C and protein phosphatase-type 1 and/or -type 2A.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acrosome Reaction; Adenosine Triphosphate; Animals; Blotting, Western; Calcium; Cells, Cultured; Chickens; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C; Signal Transduction; Sperm Motility; Spermatozoa; Stimulation, Chemical; Sulfonamides; Vitelline Membrane | 2006 |
Galpha13 mediates activation of the cytosolic phospholipase A2alpha through fine regulation of ERK phosphorylation.
Topics: Animals; Arachidonic Acid; Butadienes; CHO Cells; Cricetinae; Cricetulus; Cytosol; Enzyme Activation; Enzyme Inhibitors; Group IV Phospholipases A2; GTP-Binding Protein alpha Subunits, G12-G13; Imidazoles; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Mutation; Nitriles; Oxazoles; Phospholipases A; Phosphoric Monoester Hydrolases; Phosphorylation; Pyridines; Pyrrolidines; rhoA GTP-Binding Protein; Transfection | 2006 |
Regulatory mechanisms of ROI generation are affected by rice spl mutations.
Topics: Cell Death; Cells, Cultured; Enzyme Inhibitors; Hydrogen Peroxide; Hypersensitivity; Marine Toxins; Mutation; Oryza; Oxazoles; Ozone; Phosphoprotein Phosphatases; Reactive Oxygen Species; Signal Transduction; Wounds and Injuries | 2006 |
Activation of sodium transport in rat erythrocytes by inhibition of protein phosphatases 1 and 2A.
Topics: Amiloride; Animals; Cantharidin; Enzyme Inhibitors; Erythrocytes; Ion Transport; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Rats; Rats, Wistar; Sodium Fluoride; Sodium-Hydrogen Exchangers; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 1 | 2006 |
Linalyl acetate as a major ingredient of lavender essential oil relaxes the rabbit vascular smooth muscle through dephosphorylation of myosin light chain.
Topics: Animals; Azepines; Carotid Arteries; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Lavandula; Male; Marine Toxins; Models, Biological; Monoterpenes; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oils, Volatile; Oxazoles; Phenylephrine; Phosphorylation; Plant Oils; Rabbits; Vasoconstriction; Vasoconstrictor Agents; Vasodilation | 2006 |
The alpha4 regulatory subunit exerts opposing allosteric effects on protein phosphatases PP6 and PP2A.
Topics: Adaptor Proteins, Signal Transducing; Allosteric Site; Amino Acid Sequence; Animals; Cantharidin; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Intercellular Signaling Peptides and Proteins; Marine Toxins; Mice; Microcystins; Molecular Chaperones; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Sequence Homology, Amino Acid | 2006 |
Role of protein phosphatase 2A in calcium-dependent chloride secretion by human colonic epithelial cells.
Topics: Calcium; Carbachol; Cells, Cultured; Chlorides; Colon; Epidermal Growth Factor; Gastrointestinal Agents; Humans; Intestinal Mucosa; Marine Toxins; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 2 | 2007 |
Hypertonic stress increases phosphatidylinositol 4,5-bisphosphate levels by activating PIP5KIbeta.
Topics: Actins; Adenoviridae; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; HeLa Cells; Hemagglutinins; Humans; In Vitro Techniques; Isoenzymes; Marine Toxins; Osmotic Pressure; Oxazoles; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); RNA Interference; Urea | 2006 |
Serotonin increases phosphorylation of synaptic 4EBP through TOR, but eukaryotic initiation factor 4E levels do not limit somatic cap-dependent translation in aplysia neurons.
Topics: Amino Acid Sequence; Animals; Aplysia; Drug Antagonism; Eukaryotic Initiation Factor-4E; Marine Toxins; Molecular Sequence Data; Neurites; Neurons; Oxazoles; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Biosynthesis; Protein Serine-Threonine Kinases; Sequence Homology, Amino Acid; Serotonin; Synapses; Synaptosomes; Time Factors | 2006 |
Both Ca2+ -dependent and -independent pathways are involved in rat hepatic stellate cell contraction and intrahepatic hyperresponsiveness to methoxamine.
Topics: Actomyosin; Amides; Animals; Calcimycin; Calcium; Cell Shape; Cells, Cultured; Diacetyl; Enzyme Inhibitors; Liver; Male; Marine Toxins; Methoxamine; Myocytes, Cardiac; Myocytes, Smooth Muscle; Myosin-Light-Chain Kinase; Oxazoles; Protein Kinase Inhibitors; Pyridines; Rats; Rats, Wistar; Signal Transduction; Staurosporine; Sulfonamides; Vasoconstrictor Agents | 2007 |
Threonine phosphorylation of integrin beta3 in calyculin A-treated platelets is selectively sensitive to 5'-iodotubercidin.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Amino Acid Motifs; Amino Acid Sequence; AMP-Activated Protein Kinase Kinases; Blood Platelets; Conserved Sequence; Enzyme Activation; Humans; Integrin beta3; Marine Toxins; Mitogen-Activated Protein Kinases; Molecular Sequence Data; Oxazoles; Phosphorylation; Phosphothreonine; Platelet Aggregation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Substrate Specificity; Thrombin; Tubercidin | 2007 |
The effect of O2 tension on pH homeostasis in equine articular chondrocytes.
Topics: Adenosine Triphosphate; Animals; Cartilage, Articular; Cell Hypoxia; Chondrocytes; Enzyme Inhibitors; Homeostasis; Horses; Hydrogen-Ion Concentration; Marine Toxins; Oxazoles; Oxygen; Phosphoprotein Phosphatases; Phosphorylation; Reactive Oxygen Species; Sodium-Hydrogen Exchangers; Sodium-Potassium-Exchanging ATPase | 2006 |
Na+ entry via TRPC6 causes Ca2+ entry via NCX reversal in ATP stimulated smooth muscle cells.
Topics: Adenosine Triphosphate; Animals; Calcium; Cells, Cultured; Marine Toxins; Myocytes, Smooth Muscle; Oxazoles; Rats; Sodium; Sodium-Calcium Exchanger; TRPC Cation Channels | 2007 |
Dynamics of protein kinase C-mediated phosphorylation of the complement C5a receptor on serine 334.
Topics: Antibodies, Phospho-Specific; Arrestins; beta-Arrestins; Cell Differentiation; Complement C5a; Dose-Response Relationship, Drug; Humans; Immunologic Factors; Marine Toxins; Membrane Proteins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Kinase C; Protein Kinase C beta; Protein Processing, Post-Translational; Receptor, Anaphylatoxin C5a; Receptors, Complement; Receptors, G-Protein-Coupled; Serine; U937 Cells | 2007 |
WNK4 kinase is a negative regulator of K+-Cl- cotransporters.
Topics: Animals; Blotting, Western; Cyclosporine; Female; K Cl- Cotransporters; Marine Toxins; Mutation, Missense; Oocytes; Oxazoles; Protein Serine-Threonine Kinases; Pseudohypoaldosteronism; Symporters; Xenopus laevis; Xenopus Proteins | 2007 |
Proper chromatin condensation and maintenance of histone H3 phosphorylation during mouse oocyte meiosis requires protein phosphatase activity.
Topics: Animals; Chromatin; Chromosomes, Mammalian; Female; HeLa Cells; Histones; Humans; Marine Toxins; Meiosis; Mice; Mice, Inbred Strains; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protamine Kinase; Protein Phosphatase 1; Protein Phosphatase 2 | 2007 |
Small-molecule inhibitors of ser/thr protein phosphatases: specificity, use and common forms of abuse.
Topics: Cantharidin; Enzyme Inhibitors; Furans; Indole Alkaloids; Lactones; Lipids; Marine Toxins; Microcystins; Okadaic Acid; Organophosphates; Organophosphorus Compounds; Oxazoles; Peptides, Cyclic; Phosphoprotein Phosphatases; Pyrans; Pyrones; Spiro Compounds | 2007 |
Shrinkage insensitivity of NKCC1 in myosin II-depleted cytoplasts from Ehrlich ascites tumor cells.
Topics: Actins; Animals; Bumetanide; Carcinoma, Ehrlich Tumor; Cell Membrane; Cell Size; Cell-Free System; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases; Female; Hypertonic Solutions; Isoquinolines; Marine Toxins; Mice; Myosin Type II; Myosin-Light-Chain Kinase; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Rubidium Radioisotopes; Sodium Potassium Chloride Symporter Inhibitors; Sodium-Potassium-Chloride Symporters; Solute Carrier Family 12, Member 2; Staurosporine; Sulfonamides | 2007 |
Hybrid lethality in interspecific F1 hybrid Nicotiana gossei x N. tabacum involves a MAP-kinases signalling cascade.
Topics: Butadienes; Cell Line; Cell Survival; Enzyme Inhibitors; Hybridization, Genetic; Hydrogen Peroxide; Immunoblotting; Immunoprecipitation; MAP Kinase Signaling System; Marine Toxins; Mitogen-Activated Protein Kinases; Nicotiana; Nitriles; Okadaic Acid; Oxazoles; Phosphorylation; Plant Proteins; Plants, Genetically Modified; Seedlings; Temperature | 2007 |
Signalling pathways involved in the control of sperm cell volume.
Topics: Animals; Cell Size; Cells, Cultured; Chloride Channels; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Indoles; Ion Channels; Male; Maleimides; Marine Toxins; Okadaic Acid; Osmosis; Oxazoles; Papaverine; Phosphoprotein Phosphatases; Protein Kinase C; Signal Transduction; Spermatozoa; Staurosporine; Swine | 2007 |
Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; ADP Ribose Transferases; Botulinum Toxins; Cell Differentiation; Cell Line, Tumor; Humans; Intracellular Signaling Peptides and Proteins; Marine Toxins; Neuroblastoma; Oxazoles; Phosphorylation; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; rho GTP-Binding Proteins; rho-Associated Kinases; Signal Transduction | 2007 |
Apoptosis of human neutrophils induced by protein phosphatase 1/2A inhibition is caspase-independent and serine protease-dependent.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Apoptosis Inducing Factor; Caspase 3; Cells, Cultured; Cyclosporine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Humans; Marine Toxins; Myeloblastin; Neutrophils; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Protein Kinase C-alpha; Protein Kinase Inhibitors; Protein Phosphatase 1; Serine Endopeptidases; Serine Proteinase Inhibitors; Sulfones; Time Factors | 2007 |
Multisite phosphorylation of adipocyte and hepatocyte phosphodiesterase 3B.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Adipocytes; Amino Acid Sequence; Animals; Cells, Cultured; Cyclic AMP; Cyclic Nucleotide Phosphodiesterases, Type 3; Enzyme Activation; Gene Expression; Hepatocytes; Insulin; Lipolysis; Liver Neoplasms, Experimental; Male; Marine Toxins; Mice; Molecular Sequence Data; Oxazoles; Phosphorylation; Protein Transport; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Subcellular Fractions | 2007 |
Protein phosphatase-1 modulates the function of Pax-6, a transcription factor controlling brain and eye development.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Brain; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Eye; Eye Proteins; Homeodomain Proteins; Humans; Lens, Crystalline; Marine Toxins; Mice; Molecular Sequence Data; Oxazoles; Paired Box Transcription Factors; PAX6 Transcription Factor; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Protein Phosphatase 1; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sequence Homology, Amino Acid; Transcription, Genetic | 2007 |
Symmetrical localization of extrachromosomally replicating viral genomes on sister chromatids.
Topics: Cell Line, Tumor; Cell Nucleus; Chromatids; Chromosomal Proteins, Non-Histone; Diketopiperazines; DNA Replication; Enzyme Inhibitors; Epstein-Barr Virus Nuclear Antigens; G2 Phase; Gene Dosage; Genome, Viral; Green Fluorescent Proteins; Herpesvirus 4, Human; Humans; Hydroxyurea; In Situ Hybridization, Fluorescence; Marine Toxins; Mitosis; Models, Genetic; Oxazoles; Piperazines; Plasmids; Topoisomerase II Inhibitors | 2007 |
Extracellular ATP induces assembly and activation of the myosin light chain phosphatase complex in endothelial cells.
Topics: Adenosine Triphosphate; Amides; Blotting, Western; Cells, Cultured; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Immunoprecipitation; Intracellular Signaling Peptides and Proteins; Marine Toxins; Myosin-Light-Chain Phosphatase; Nucleotidases; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Serine-Threonine Kinases; Proteins; Purinergic P1 Receptor Antagonists; Pyridines; rho-Associated Kinases; Theophylline; Thrombin; Transfection | 2007 |
Obtaining metaphase spreads from single blastomeres for PGD of chromosomal rearrangements.
Topics: Animals; Blastomeres; Caffeine; Chromosome Aberrations; Culture Media; Cytoplasm; Demecolcine; Embryo Culture Techniques; Humans; Marine Toxins; Metaphase; Mice; Oxazoles; Paclitaxel; Preimplantation Diagnosis; Zygote | 2007 |
Biodosimetry estimate for high-LET irradiation.
Topics: Chromosome Aberrations; Humans; Interphase; Linear Energy Transfer; Lymphocytes; Marine Toxins; Metaphase; Oxazoles; Radiation Dosage; Radiation Injuries; Reference Values | 2007 |
Inhibition of protein phosphatases induces transport deficits and axonopathy.
Topics: Animals; Axonal Transport; Axons; Brain; Cell Differentiation; Cell Line, Tumor; Enzyme Inhibitors; Image Cytometry; Marine Toxins; Memory Disorders; Mice; Nerve Degeneration; Neurites; Neurofilament Proteins; Oxazoles; Phosphoprotein Phosphatases | 2007 |
Calyculin A stimulates the expression of TNF-alpha mRNA via phosphorylation of Akt in mouse osteoblastic MC3T3-E1 cells.
Topics: 3T3 Cells; Animals; Enzyme Inhibitors; Marine Toxins; Mice; Mitogen-Activated Protein Kinases; NF-kappa B; Oxazoles; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha | 2007 |
NMDA receptor-mediated extracellular adenosine accumulation is blocked by phosphatase 1/2A inhibitors.
Topics: Adenosine; Animals; Enzyme Inhibitors; Indoles; Maleimides; Marine Toxins; Naphthalenes; Neuronal Plasticity; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Kinase C; Rats; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission | 2007 |
The benzene metabolite hydroquinone enhances G2-chromosomal radiosensitivity by inducing a less-efficient G2-M-checkpoint in irradiated lymphocytes.
Topics: Benzene; Carcinogens; Cell Division; Cells, Cultured; Chromosome Aberrations; G2 Phase; Humans; Hydroquinones; Karyotyping; Lymphocytes; Marine Toxins; Oxazoles; Radiation Tolerance | 2007 |
Functional analysis of the PP2A subfamily of protein phosphatases in regulating Drosophila S6 kinase.
Topics: Animals; Cells, Cultured; Drosophila melanogaster; Drosophila Proteins; Enzyme Inhibitors; Marine Toxins; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Isoforms; Protein Kinases; Protein Phosphatase 2; Protein Subunits; Ribosomal Protein S6 Kinases; RNA Interference; TOR Serine-Threonine Kinases | 2007 |
Calyculin A induces apoptosis and stimulates phosphorylation of p65NF-kappaB in human osteoblastic osteosarcoma MG63 cells.
Topics: Apoptosis; Binding Sites; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Enzyme Inhibitors; Humans; Marine Toxins; Mutation; Osteoblasts; Osteosarcoma; Oxazoles; Phosphorylation; Serine; Transcription Factor RelA; Transcription, Genetic | 2007 |
A comparison of G2 phase radiation-induced chromatid break kinetics using calyculin-PCC with those obtained using colcemid block.
Topics: Animals; Antimetabolites; Biological Assay; Carcinogens; Cell Line; Chromatids; Chromosome Breakage; Cricetinae; Demecolcine; DNA Breaks, Double-Stranded; G2 Phase; Gamma Rays; Kinetics; Marine Toxins; Oxazoles; Vidarabine | 2007 |
Mechanisms of Rho kinase regulation of vascular reactivity following hemorrhagic shock in rats.
Topics: Angiotensin II; Animals; Azepines; Calcium; Cell Hypoxia; In Vitro Techniques; Marine Toxins; Mesenteric Artery, Superior; Myocytes, Smooth Muscle; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oxazoles; Rats; Rats, Wistar; rho-Associated Kinases; Shock, Hemorrhagic; Vasoconstriction | 2008 |
Actin-myosin network reorganization breaks symmetry at the cell rear to spontaneously initiate polarized cell motility.
Topics: Actins; Animals; Cell Movement; Cell Nucleus; Cell Polarity; Cell Shape; Epithelial Cells; Fishes; Intracellular Signaling Peptides and Proteins; Marine Toxins; Models, Biological; Myosins; Oxazoles; Protein Serine-Threonine Kinases; rho-Associated Kinases; Xenopus | 2007 |
Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets.
Topics: Amino Acid Sequence; Animals; Cell Membrane; Chlorocebus aethiops; COS Cells; Dimerization; Humans; Marine Toxins; Mice; Molecular Sequence Data; NIH 3T3 Cells; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Receptors, Adrenergic, beta-2; Sequence Homology, Amino Acid; Sodium-Hydrogen Exchangers | 2007 |
Cyclic AMP-independent CGRP8-37-sensitive receptors mediate adrenomedullin-induced decrease of CaCl2-contraction in pregnant rat mesenteric artery.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Adrenomedullin; Animals; Calcitonin Gene-Related Peptide; Calcium Chloride; Calcium Signaling; Calcium-Transporting ATPases; Cells, Cultured; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Marine Toxins; Membrane Potentials; Mesenteric Arteries; Muscle, Smooth, Vascular; Myosin-Light-Chain Phosphatase; Oxazoles; Peptide Fragments; Phosphorylation; Potassium; Pregnancy; Protein Phosphatase 1; Rats; Receptors, Adrenomedullin; Receptors, G-Protein-Coupled; Sodium Fluoride; Thapsigargin; Time Factors; Vasoconstriction; Vasoconstrictor Agents | 2008 |
Applying a targeted label-free approach using LC-MS AMT tags to evaluate changes in protein phosphorylation following phosphatase inhibition.
Topics: Amino Acid Sequence; Chromatography, Ion Exchange; Chromatography, Liquid; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; HeLa Cells; Humans; Marine Toxins; Mass Spectrometry; Models, Biological; Molecular Sequence Data; Oxazoles; Peptides; Phosphopeptides; Phosphorylation; Proteomics | 2007 |
Quantifying myosin light chain phosphorylation in single adherent cells with automated fluorescence microscopy.
Topics: Actin Cytoskeleton; Amides; Animals; Automation; Cell Adhesion; Cell Communication; Cell Line; Cell Movement; Cell Shape; Dose-Response Relationship, Drug; Extracellular Matrix; Marine Toxins; Mice; Microscopy, Fluorescence; Myosin Light Chains; NIH 3T3 Cells; Oxazoles; Permeability; Phosphorylation; Pyridines; Rats; Tissue Fixation | 2007 |
Dehydroevodiamine attenuates calyculin A-induced tau hyperphosphorylation in rat brain slices.
Topics: Alkaloids; Animals; In Vitro Techniques; Male; Marine Toxins; Oxazoles; Phosphorylation; Prosencephalon; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; tau Proteins; Tyrosine | 2007 |
Stringent time-dependent transregulation of calcium calmodulin kinase II (CaMKII) is implicated in anti-apoptotic control.
Topics: Animals; Apoptosis; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line; Cell Shape; Dogs; Enzyme Inhibitors; Intracellular Membranes; Kinetics; Male; Marine Toxins; Mice; Mutant Proteins; Oxazoles; Phosphorylation; Rats; Rats, Wistar; Sulfonamides; Time Factors | 2008 |
Calyculin A retraction of mature megakaryocytes proplatelets from embryonic stem cells.
Topics: Animals; Blood Platelets; Cell Culture Techniques; Cell Differentiation; Cell Line; Embryonic Stem Cells; Marine Toxins; Megakaryocytes; Mice; Oxazoles | 2008 |
Emetine regulates the alternative splicing of Bcl-x through a protein phosphatase 1-dependent mechanism.
Topics: Alternative Splicing; bcl-X Protein; Breast Neoplasms; Cell Line, Tumor; Cycloheximide; Down-Regulation; Emetine; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Lung Neoplasms; Male; Marine Toxins; Okadaic Acid; Oxazoles; Prostatic Neoplasms; Protein Phosphatase 1; Protein Phosphatase 2; Up-Regulation; Uterine Cervical Neoplasms | 2007 |
Synergistic activation of the Arabidopsis NADPH oxidase AtrbohD by Ca2+ and phosphorylation.
Topics: Amino Acid Motifs; Arabidopsis; Arabidopsis Proteins; Calcium; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydrophobic and Hydrophilic Interactions; Ionomycin; Ionophores; Marine Toxins; Multienzyme Complexes; NADH, NADPH Oxidoreductases; Oxazoles; Phosphorylation; Protein Structure, Tertiary; Reactive Oxygen Species | 2008 |
[Dose-effect relationship between premature chromosome and irradiation dose].
Topics: Cell Line; Chromosome Aberrations; Chromosome Banding; Chromosomes; Dose-Response Relationship, Radiation; Female; Gamma Rays; Humans; Lymphocytes; Male; Marine Toxins; Oxazoles; Young Adult | 2007 |
Effects of protein phosphatase inhibitor calyculin a on the postacrosomal protein serine/threonine phosphorylation state and acrosome reaction in boar spermatozoa incubated with a cAMP analog.
Topics: Acrosome; Acrosome Reaction; Animals; Chlortetracycline; Cyclic AMP; Dichlororibofuranosylbenzimidazole; Enzyme Inhibitors; Male; Marine Toxins; Oxazoles; Phosphorylation; Protein Phosphatase 1; Protein Synthesis Inhibitors; Serine; Sus scrofa; Thionucleotides; Threonine | 2008 |
Local positive feedback regulation determines cell shape in root hair cells.
Topics: Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Calcium; Cation Transport Proteins; Cell Line; Cell Shape; EF Hand Motifs; Endocytosis; Feedback, Physiological; Humans; Marine Toxins; Mutant Proteins; NADPH Oxidases; Oxazoles; Phosphorylation; Plant Roots; Protein Structure, Tertiary; Reactive Oxygen Species; Recombinant Fusion Proteins | 2008 |
An improved assay for radiation-induced chromatid breaks using a colcemid block and calyculin-induced PCC combination.
Topics: Antineoplastic Agents; Breast Neoplasms; Carcinogens; Cells, Cultured; Chromatids; Chromatin Assembly and Disassembly; Chromosome Breakage; Chromosomes, Human; Demecolcine; Humans; Marine Toxins; Mutagenicity Tests; Oxazoles; Radiation Injuries | 2008 |
Effects of protein phosphatase inhibitors on the phosphorylation of spinal cord N-methyl-D-aspartate receptors following electroacupuncture stimulation in rats.
Topics: Animals; Behavior, Animal; Dose-Response Relationship, Drug; Electroacupuncture; Enzyme Inhibitors; Hyperalgesia; Male; Marine Toxins; Oxazoles; Pain Measurement; Pain Threshold; Phosphorylation; Proto-Oncogene Proteins c-fos; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, N-Methyl-D-Aspartate; Spinal Cord | 2008 |
Nuclear Dbf2-related protein kinases (NDRs) in isolated cardiac myocytes and the myocardium: activation by cellular stresses and by phosphoprotein serine-/threonine-phosphatase inhibitors.
Topics: Animals; Cells, Cultured; Cloning, Molecular; Enzyme Activation; Enzyme Inhibitors; Female; Marine Toxins; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Osmotic Pressure; Oxazoles; Oxidative Stress; Phosphoprotein Phosphatases; Protein Serine-Threonine Kinases; Rats; Threonine | 2008 |
Calyculin-A improves chromosome condensation for cytogenetic analysis of blastomeres from bovine and murine eight-cell stage embryos.
Topics: Animals; Blastomeres; Cattle; Chromosomes, Mammalian; Cytogenetic Analysis; Enzyme Inhibitors; Marine Toxins; Mice; Oxazoles | 2008 |
Myosin phosphatase interacts with and dephosphorylates the retinoblastoma protein in THP-1 leukemic cells: its inhibition is involved in the attenuation of daunorubicin-induced cell death by calyculin-A.
Topics: Caspase 3; Cell Death; Cell Line; Cell Survival; Daunorubicin; Humans; Immunoprecipitation; Leukemia; Marine Toxins; Myosin-Light-Chain Phosphatase; Oxazoles; Phosphorylation; Protein Binding; Protein Phosphatase 1; Protein Processing, Post-Translational; Protein Subunits; Protein Transport; Retinoblastoma Protein; Subcellular Fractions; Surface Plasmon Resonance | 2008 |
Cellular serine/threonine phosphatase activity during human cytomegalovirus infection.
Topics: Animals; Cells, Cultured; Cytomegalovirus Infections; eIF-2 Kinase; Enzyme Inhibitors; Eukaryotic Initiation Factor-2; Humans; Marine Toxins; Mice; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Biosynthesis | 2008 |
G2-phase chromatid break kinetics in irradiated DNA repair mutant hamster cell lines using calyculin-induced PCC and colcemid-block.
Topics: Animals; Cell Line; Chromosome Breakage; Cricetinae; Demecolcine; DNA Repair; G2 Phase; Gamma Rays; Kinetics; Marine Toxins; Mutation; Oxazoles | 2008 |
Mitotic delay in lymphocytes from BRCA1 heterozygotes unable to reduce the radiation-induced chromosomal damage.
Topics: Animals; BRCA1 Protein; Cell Cycle; Cell Division; Chromosomes; Demecolcine; DNA Damage; Female; G2 Phase; Heterozygote; Lymphocytes; Marine Toxins; Mice; Mitosis; Models, Biological; Oxazoles | 2008 |
Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism.
Topics: AMP-Activated Protein Kinases; Cell Line, Tumor; Cell Proliferation; Chromones; Curcumin; DNA, Neoplasm; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Activation; Humans; Marine Toxins; Models, Biological; Morpholines; Multienzyme Complexes; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Protein Biosynthesis; Protein Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyruvate Dehydrogenase Acetyl-Transferring Kinase; Signal Transduction; Time Factors; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 1 Protein; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2008 |
Activation of Na+/H+ and K+/H+ exchange by calyculin A in Amphiuma tridactylum red blood cells: implications for the control of volume-induced ion flux activity.
Topics: Amiloride; Animals; Cell Size; Dose-Response Relationship, Drug; Enzyme Inhibitors; Erythrocytes; Marine Toxins; Osmotic Pressure; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Potassium; Potassium-Hydrogen Antiporters; Protein Kinases; Ruthenium; Sodium; Sodium-Hydrogen Exchangers; Time Factors; Urodela | 2008 |
Calculating reaction rate constants and estimating the efficacy of selective enzyme inhibitors.
Topics: Cardiac Myosins; Enzyme Inhibitors; Kinetics; Marine Toxins; Myocytes, Cardiac; Myosin Light Chains; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Time | 2008 |
Maximal stimulation-induced in situ myosin light chain kinase activity is upregulated in fetal compared with adult ovine carotid arteries.
Topics: Age Factors; Aging; Animals; Azepines; Calmodulin; Carotid Artery, Common; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fetus; Marine Toxins; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Naphthalenes; Oxazoles; Phosphorylation; Sheep; Time Factors; Up-Regulation; Vasoconstriction | 2008 |
Quantitative phosphoproteome analysis of a mouse liver cell line reveals specificity of phosphatase inhibitors.
Topics: Animals; Cell Line, Tumor; Chromatography, Liquid; Computational Biology; Hepatocytes; Insulin; Liver; Marine Toxins; Mice; Nitriles; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Tyrosine Phosphatases; Proteome; Pyrethrins; Substrate Specificity; Tandem Mass Spectrometry; Transcription Factors; Vanadates | 2008 |
Ovarian stimulation with FSH reduces phosphorylation of gonadotrope progesterone receptor and LH secretion in the rat.
Topics: Animals; Depression, Chemical; Estradiol; Female; Follicle Stimulating Hormone, Human; Gonadotrophs; Gonadotropin-Releasing Hormone; Immunohistochemistry; Luteinizing Hormone; Marine Toxins; Organ Culture Techniques; Ovary; Oxazoles; Phosphorylation; Proestrus; Progesterone; Rats; Rats, Wistar; Receptors, Progesterone | 2009 |
Inhibition of serine/threonine phosphatase enhances arachidonic acid-induced [Ca2+]i via protein kinase A.
Topics: A Kinase Anchor Proteins; Animals; Arachidonic Acid; Calcium Channel Blockers; Calcium Signaling; Calcium-Transporting ATPases; Cholinergic Agonists; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Marine Toxins; Mice; Oxazoles; Parotid Gland; Peptide Fragments; Protein Kinase Inhibitors; Protein Phosphatase 1; Protein Phosphatase 2; Ryanodine Receptor Calcium Release Channel; Time Factors | 2009 |
The actin cytoskeleton differentially regulates NG115-401L cell ryanodine receptor and inositol 1,4,5-trisphosphate receptor induced calcium signaling pathways.
Topics: Actins; Animals; Calcium Signaling; Cell Line, Tumor; Cerebral Cortex; Cytochalasin D; Cytoskeleton; Inositol 1,4,5-Trisphosphate Receptors; Marine Toxins; Oxazoles; Ryanodine Receptor Calcium Release Channel | 2009 |
Inhibition of TNF-alpha-induced cyclooxygenase-2 expression by Mycobacterium bovis BCG in human alveolar epithelial A549 cells.
Topics: BCG Vaccine; Cell Line, Tumor; Cyclooxygenase 2; Down-Regulation; Epithelial Cells; Gene Expression Regulation; Humans; I-kappa B Proteins; Marine Toxins; Mycobacterium bovis; NF-kappa B; Oxazoles; p38 Mitogen-Activated Protein Kinases; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins c-raf; Pulmonary Alveoli; Tumor Necrosis Factor-alpha | 2009 |
Cell traction forces direct fibronectin matrix assembly.
Topics: Algorithms; Animals; Cell Adhesion; Extracellular Matrix; Fibronectins; Fluorescent Antibody Technique; Heterocyclic Compounds, 4 or More Rings; Image Processing, Computer-Assisted; Marine Toxins; Mice; Myosin Type II; NIH 3T3 Cells; Oxazoles | 2009 |
PI3K/Akt mediates expression of TNF-alpha mRNA and activation of NF-kappaB in calyculin A-treated primary osteoblasts.
Topics: Animals; Animals, Newborn; Blotting, Western; Cell Nucleus; Cells, Cultured; Chromones; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Glyceraldehyde-3-Phosphate Dehydrogenases; Marine Toxins; Morpholines; NF-kappa B; Osteoblasts; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoprotein Phosphatases; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Signal Transduction; Time Factors; Tumor Necrosis Factor-alpha | 2008 |
Phosphoregulation of K(+)-Cl(-) cotransporter 4 during changes in intracellular Cl(-) and cell volume.
Topics: Animals; Cell Size; Chlorides; Female; In Vitro Techniques; Intracellular Fluid; Marine Toxins; Mice; Mutagenesis, Site-Directed; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Recombinant Proteins; Signal Transduction; Symporters; Tetradecanoylphorbol Acetate; Transfection; Xenopus laevis | 2009 |
Transient inhibition of Calyculin A induced premature chromosome condensation by hyperthermia.
Topics: Carcinoma, Squamous Cell; CDC2 Protein Kinase; Cell Line, Tumor; Chromatin Assembly and Disassembly; Chromosome Aberrations; Cyclin B; Cyclin B1; Cyclin-Dependent Kinases; Female; Fever; Histones; Humans; Hyperthermia, Induced; Lung Neoplasms; Marine Toxins; Oxazoles; Phosphorylation; Uterine Cervical Neoplasms | 2009 |
Calyculin-A induces cleavage in a random plane in unfertilized sea urchin eggs.
Topics: Animals; Cell Division; Enzyme Inhibitors; Female; Marine Toxins; Ovum; Oxazoles; Sea Urchins | 2009 |
Calyculin A-sensitive protein phosphatases are involved in maintenance of progressive movement in mouse spermatozoa in vitro by suppression of autophosphorylation of protein kinase A.
Topics: Animals; Cyclic AMP-Dependent Protein Kinases; Dichlororibofuranosylbenzimidazole; Drug Resistance; Enzyme Inhibitors; Male; Marine Toxins; Mice; Mice, Inbred ICR; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Sperm Motility; Spermatozoa; Thionucleotides | 2009 |
Myosin light chain phosphatase activation is involved in the hydrogen sulfide-induced relaxation in mouse gastric fundus.
Topics: Adenine; Amides; Animals; Enzyme Activation; Gastric Fundus; Glyburide; Hydrogen Sulfide; In Vitro Techniques; Male; Marine Toxins; Mice; Muscle Relaxation; Myosin-Light-Chain Phosphatase; NG-Nitroarginine Methyl Ester; omega-Conotoxins; Oxazoles; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Tetrodotoxin | 2009 |
Signaling pathways of kaempferol-3-neohesperidoside in glycogen synthesis in rat soleus muscle.
Topics: Adjuvants, Immunologic; Androstadienes; Animals; Enzyme Inhibitors; Flavonoids; Glycogen; Glycogen Synthase Kinase 3; Hypoglycemic Agents; Insulin; Insulin Antagonists; Kaempferols; Lithium Chloride; Male; Marine Toxins; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Phosphatase 1; Rats; Rats, Wistar; Signal Transduction; Wortmannin | 2009 |
Protein phosphatase inhibitor-1 augments a protein kinase A-dependent increase in the Ca2+ loading of the sarcoplasmic reticulum without changing its Ca2+ release.
Topics: Adrenergic beta-Agonists; Animals; Calcium; Calcium Signaling; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Homeostasis; Isoproterenol; Male; Marine Toxins; Models, Animal; Myocytes, Cardiac; Oxazoles; Patch-Clamp Techniques; Proteins; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum; Signal Transduction | 2009 |
Optical signatures of molecular dissymmetry: combining theory with experiments to address stereochemical puzzles.
Topics: Circular Dichroism; Ethers, Cyclic; Marine Toxins; Models, Chemical; Optical Rotatory Dispersion; Organophosphates; Oxazoles; Spectrum Analysis, Raman; Stereoisomerism | 2009 |
Drug-induced premature chromosome condensation (PCC) protocols: cytogenetic approaches in mitotic chromosome and interphase chromatin.
Topics: Animals; Cell Adhesion; Chromatin; Cytogenetics; Humans; Interphase; Marine Toxins; Mitosis; Oxazoles | 2009 |
ROS activate KCl cotransport in nonadherent Ehrlich ascites cells but K+ and Cl- channels in adherent Ehrlich Lettré and NIH3T3 cells.
Topics: Animals; Carboxylic Acids; Carcinoma, Ehrlich Tumor; Cell Adhesion; Cell Line, Tumor; Cell Size; Chloride Channels; Enzyme Inhibitors; Female; Fibroblasts; Hydrogen Peroxide; Hypotonic Solutions; Indenes; Ion Transport; K Cl- Cotransporters; Marine Toxins; Mice; NIH 3T3 Cells; Nitrates; Osmotic Pressure; Oxazoles; Oxidative Stress; Phosphoprotein Phosphatases; Phosphorylation; Potassium Channels; Reactive Oxygen Species; Symporters; Time Factors | 2009 |
Reversible phosphorylation as a molecular switch to regulate plasma membrane targeting of acylated SH4 domain proteins.
Topics: Animals; Antigens, Protozoan; Cell Membrane; CHO Cells; Cricetinae; Cricetulus; Endosomes; Enzyme Inhibitors; Glutamic Acid; Golgi Apparatus; Leishmania; Marine Toxins; Mutation; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Structure, Tertiary; Protein Transport; Proto-Oncogene Proteins c-yes; Protozoan Proteins; Recombinant Fusion Proteins; RNA Interference; Threonine | 2009 |
Phosphatase inhibition and cell survival after DNA damage induced by radiation.
Topics: Cell Line, Tumor; DNA Damage; DNA, Neoplasm; Humans; Marine Toxins; Nuclear Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Phosphorylation; Proto-Oncogene Proteins c-akt; Radiation Tolerance; RNA, Small Interfering; Signal Transduction; Transfection | 2009 |
Transient dephosphorylation of p53 serine 376 as an early response to ionizing radiation.
Topics: Amino Acid Sequence; Autoantibodies; Blotting, Western; Cell Line, Tumor; Cell Nucleus; Cesium Radioisotopes; Cycloheximide; Cytoplasm; Dose-Response Relationship, Radiation; Enzyme Inhibitors; Gamma Rays; Humans; Marine Toxins; Microscopy, Fluorescence; Oxazoles; Phosphorylation; Protein Synthesis Inhibitors; Time Factors; Tumor Suppressor Protein p53 | 2009 |
Calcium-dependent and calcium-independent inhibition of contraction by cGMP/cGKI in intestinal smooth muscle.
Topics: Amides; Animals; Calcium Signaling; Carbachol; Cholinergic Agonists; Colon; Cyclic GMP; Cyclic GMP-Dependent Protein Kinases; Enzyme Inhibitors; In Vitro Techniques; Jejunum; Marine Toxins; Membrane Proteins; Mice; Mice, Knockout; Muscle Relaxation; Muscle, Smooth; Mutation; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Pyridines; rho-Associated Kinases; Time Factors | 2009 |
Functional study of the effect of phosphatase inhibitors on KCNQ4 channels expressed in Xenopus oocytes.
Topics: Action Potentials; Animals; Cyclosporine; Humans; Indoles; KCNQ Potassium Channels; Maleimides; Marine Toxins; Okadaic Acid; Oocytes; Oxazoles; Phosphoprotein Phosphatases; Phosphoric Monoester Hydrolases; Potassium Channel Blockers; Protein Kinase C; Pyridines; Xenopus laevis | 2009 |
Complex phosphatase regulation of Ca2+-activated Cl- currents in pulmonary arterial smooth muscle cells.
Topics: Animals; Calcium; Cantharidin; Chlorine; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Intracellular Signaling Peptides and Proteins; Lung; Marine Toxins; Myocytes, Smooth Muscle; Okadaic Acid; Oxazoles; Patch-Clamp Techniques; Phosphoric Monoester Hydrolases; Pulmonary Artery; Rabbits | 2009 |
Calyculin A-induced neurite retraction is critically dependent on actomyosin activation but not on polymerization state of microtubules.
Topics: Actomyosin; Animals; Cells, Cultured; Enzyme Inhibitors; Hippocampus; Marine Toxins; Microtubules; Neurites; Oxazoles; Phosphoprotein Phosphatases; Rats | 2009 |
Thr435 phosphorylation regulates RelA (p65) NF-kappaB subunit transactivation.
Topics: Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Chemokine CXCL2; Gene Expression Regulation; Histone Deacetylase 1; Humans; Immunoprecipitation; Marine Toxins; Mice; Mice, Knockout; Mutation; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Threonine; Transcription Factor RelA; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2010 |
NHE3 function and phosphorylation are regulated by a calyculin A-sensitive phosphatase.
Topics: Animals; Blotting, Western; Chlorocebus aethiops; COS Cells; Electrophoretic Mobility Shift Assay; Enzyme Inhibitors; Humans; Kidney Tubules, Proximal; Kinetics; Male; Marine Toxins; Microvilli; Mutation; Nuclear Proteins; Okadaic Acid; Opossums; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers; Transfection | 2010 |
Synthesis of natural products containing spiroketals via intramolecular hydrogen abstraction.
Topics: Anthelmintics; Anti-Bacterial Agents; Antineoplastic Agents; Benzofurans; Biological Products; Bridged-Ring Compounds; Ciguatoxins; Cyclization; Ethers; Ethers, Cyclic; Furans; Hydrogen; Ivermectin; Marine Toxins; Molecular Structure; Oxazoles; Oxidation-Reduction; Phenazines; Phosphoprotein Phosphatases; Pyrans; Spiro Compounds | 2010 |
Inhibition of Ser/Thr phosphatases induces capacitation-associated signaling in the presence of Src kinase inhibitors.
Topics: Aniline Compounds; Animals; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Female; Indoles; Male; Marine Toxins; Mice; Mice, Inbred Strains; Mice, Mutant Strains; Nitriles; Okadaic Acid; Oxazoles; Phosphorylation; Protein Serine-Threonine Kinases; Quinolines; Signal Transduction; Sperm Capacitation; Sperm-Ovum Interactions; Spermatozoa; src-Family Kinases; Sulfonamides; Tyrosine | 2010 |
Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice.
Topics: Animals; Calcium Channels, L-Type; Cytosol; Electrophysiology; Enzyme Activators; Enzyme Inhibitors; Indicators and Reagents; Marine Toxins; Mice; Mice, Knockout; Microdialysis; Muscle, Smooth; Myocytes, Smooth Muscle; Oxazoles; Patch-Clamp Techniques; Phorbol 12,13-Dibutyrate; Phosphoric Monoester Hydrolases; Protein Kinase C; Sodium-Calcium Exchanger | 2010 |
Regulation of postsynaptic gephyrin cluster size by protein phosphatase 1.
Topics: Animals; Carrier Proteins; Cells, Cultured; Cytoskeleton; Enzyme Inhibitors; Hippocampus; Humans; Marine Toxins; Membrane Proteins; Neurons; Okadaic Acid; Oxazoles; Protein Phosphatase 1; Rats; Receptors, GABA; Recombinant Fusion Proteins; Synapses | 2010 |
The cytoplasmic domains of TNFalpha-converting enzyme (TACE/ADAM17) and L-selectin are regulated differently by p38 MAPK and PKC to promote ectodomain shedding.
Topics: ADAM Proteins; ADAM17 Protein; Animals; Cantharidin; Cell Line; Cells, Cultured; Cytoskeletal Proteins; Enzyme Inhibitors; Enzyme-Linked Immunosorbent Assay; Flow Cytometry; Humans; Immunoblotting; Immunoprecipitation; L-Selectin; Marine Toxins; Membrane Proteins; Mice; Microfilament Proteins; Oxazoles; p38 Mitogen-Activated Protein Kinases; Protein Kinase C; Protein Structure, Tertiary; Tetradecanoylphorbol Acetate; U937 Cells | 2010 |
Protein kinase C inhibits autophagy and phosphorylates LC3.
Topics: Autophagy; Cell Line; Enzyme Activation; Enzyme Inhibitors; Humans; Marine Toxins; Microtubule-Associated Proteins; Oxazoles; Phagosomes; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate | 2010 |
Temperature-dependent regulation of sperm motility of Ijima's copper pheasants (Syrmaticus soemmerringii ijimae), one of 'near threatened' species.
Topics: Animals; Calcium Chloride; Chickens; Cyclic AMP; Endangered Species; Galliformes; Male; Marine Toxins; Oxazoles; Semen; Sperm Motility; Temperature | 2010 |
Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.
Topics: Alzheimer Disease; Animals; Antioxidants; Behavior, Animal; Disease Models, Animal; Male; Malondialdehyde; Marine Toxins; Melatonin; Memory Disorders; Oxazoles; Oxidative Stress; Phosphorylation; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; tau Proteins | 2011 |
Protein phosphatase inhibitor calyculin-A modulates activation markers in TRAP-stimulated human platelets.
Topics: Blood Platelets; Down-Regulation; Enzyme Inhibitors; Humans; Marine Toxins; Oxazoles; P-Selectin; Peptide Fragments; Platelet Activation; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Phosphatase 1; Protein Phosphatase 2; Receptors, IgG | 2010 |
Mechanism of activation of PKB/Akt by the protein phosphatase inhibitor Calyculin A.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Chromones; Embryonic Stem Cells; Enzyme Inhibitors; Imidazoles; Insulin Receptor Substrate Proteins; Insulin-Like Growth Factor I; Marine Toxins; Mice; Mitogen-Activated Protein Kinase 11; Morpholines; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Pyridines | 2010 |
Negative feedback regulation of microbe-associated molecular pattern-induced cytosolic Ca2+ transients by protein phosphorylation.
Topics: Aequorin; Apoproteins; Calcium; Cell Line; Host-Pathogen Interactions; Immunity, Innate; Marine Toxins; Mitogen-Activated Protein Kinases; Oligosaccharides; Oryza; Oxazoles; Phosphorylation; Plants, Genetically Modified; Reactive Oxygen Species; Recombinant Proteins | 2011 |
Structure-functional analyses of CRHSP-24 plasticity and dynamics in oxidative stress response.
Topics: Amino Acid Substitution; DNA-Binding Proteins; Enzyme Inhibitors; HeLa Cells; Humans; Marine Toxins; Mutation, Missense; Oxazoles; Oxidative Stress; Phosphoprotein Phosphatases; Phosphoproteins; Protein Phosphatase 2; Protein Structure, Secondary; Structure-Activity Relationship; Transcription Factors | 2011 |
Melatonin reduces the impairment of axonal transport and axonopathy induced by calyculin A.
Topics: Animals; Axonal Transport; Axons; Blotting, Western; Cell Line; Cell Survival; Malondialdehyde; Marine Toxins; Melatonin; Mice; Oxazoles; Superoxide Dismutase | 2011 |
Berberine attenuates calyculin A-induced cytotoxicity and Tau hyperphosphorylation in HEK293 cells.
Topics: Analysis of Variance; Berberine; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Flow Cytometry; HEK293 Cells; Humans; In Situ Nick-End Labeling; Malondialdehyde; Marine Toxins; Oxazoles; Phosphorylation; Protein Phosphatase 2; Sincalide; Superoxide Dismutase; tau Proteins | 2011 |
Protein phosphatase 1-dependent dephosphorylation of Akt is the prime signaling event in sphingosine-induced apoptosis in Jurkat cells.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Blotting, Western; Caspase 3; Cell Survival; Enzyme Activation; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Immunoprecipitation; Jurkat Cells; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Phosphatase 1; Proto-Oncogene Proteins c-akt; Pyrans; Serine; Signal Transduction; Sphingosine; Spiro Compounds | 2011 |
Enhanced contractility and myosin phosphorylation induced by Ca(2+)-independent MLCK activity in hypertensive rats.
Topics: Analysis of Variance; Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Death-Associated Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Inhibitors; Hypertension; Male; Marine Toxins; Mesenteric Arteries; Muscle Proteins; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Up-Regulation; Vasoconstriction; Vasoconstrictor Agents | 2011 |
Actomyosin-generated tension controls the molecular kinetics of focal adhesions.
Topics: Actomyosin; Cell Line, Tumor; Cytoskeletal Proteins; Fluorescence Recovery After Photobleaching; Focal Adhesions; Glycoproteins; Heterocyclic Compounds, 4 or More Rings; Humans; Marine Toxins; Oxazoles; Paxillin; Vinculin; Zyxin | 2011 |
Muscarinic-activated potassium current mediates the negative chronotropic effect of pilocarpine on the rabbit sinoatrial node.
Topics: Acetylcholine; Action Potentials; Animals; Bee Venoms; Cesium; Enzyme Inhibitors; Ion Channel Gating; Marine Toxins; Muscarinic Agonists; Myocytes, Cardiac; Oxazoles; Patch-Clamp Techniques; Pilocarpine; Potassium; Potassium Channel Blockers; Potassium Channels; Rabbits; Sinoatrial Node | 2011 |
Adrenergic regulation of the distribution of transducer of regulated cAMP-response element-binding protein (TORC2) in rat pinealocytes.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic beta-Antagonists; Animals; Circadian Rhythm; Cyclic AMP Response Element-Binding Protein; Enzyme Inhibitors; Male; Marine Toxins; Norepinephrine; Okadaic Acid; Oxazoles; Phosphorylation; Pineal Gland; Prazosin; Propranolol; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Signal Transduction; Trans-Activators; Transcription Factors | 2011 |
The NADPH oxidase cytosolic component p67phox is constitutively phosphorylated in human neutrophils: Regulation by a protein tyrosine kinase, MEK1/2 and phosphatases 1/2A.
Topics: Cells, Cultured; Gene Expression Regulation, Enzymologic; Humans; MAP Kinase Kinase 1; MAP Kinase Kinase 2; Marine Toxins; Mitogen-Activated Protein Kinase Kinases; NADPH Oxidases; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2 | 2011 |
Rapid dephosphorylation of G protein-coupled receptors by protein phosphatase 1β is required for termination of β-arrestin-dependent signaling.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Arrestins; beta-Arrestins; Biocatalysis; Cell Membrane; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; HEK293 Cells; Humans; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Phosphatase 1; Rats; Receptors, Somatostatin; Serine; Signal Transduction; Time Factors | 2011 |
Prematurely condensed chromosome rings after neutron irradiation of human lymphocytes.
Topics: Cell Cycle; Chromosome Aberrations; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Lymphocyte Count; Lymphocytes; Marine Toxins; Neutrons; Oxazoles; Poisson Distribution; Radiation Dosage; Radiometry; Ring Chromosomes | 2011 |
Clofibrate relaxes the longitudinal smooth muscle of the mouse distal colon through calcium-mediated desensitisation of contractile machinery.
Topics: Anilides; Animals; Anticholesteremic Agents; Benzamides; Calcium; Clofibrate; Colon; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Drug Evaluation, Preclinical; Guanylate Cyclase; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Myosin-Light-Chain Phosphatase; Nitric Oxide Synthase; Oxazoles; Potassium Channel Blockers; PPAR alpha; Pyridines; Pyrimidines; Receptors, Cytoplasmic and Nuclear; Sodium Channel Blockers; Soluble Guanylyl Cyclase | 2011 |
Protein phosphorylation is a prerequisite for the Ca2+-dependent activation of Arabidopsis NADPH oxidases and may function as a trigger for the positive feedback regulation of Ca2+ and reactive oxygen species.
Topics: Arabidopsis; Arabidopsis Proteins; Calcium; Calcium Ionophores; Enzyme Inhibitors; Feedback, Physiological; HEK293 Cells; Humans; Ionomycin; Marine Toxins; NADPH Oxidases; Oxazoles; Phosphorylation; Reactive Oxygen Species; Signal Transduction | 2012 |
Optimization of calyculin A-induced premature chromosome condensation assay for chromosome aberration studies.
Topics: Biological Assay; Cell Cycle; Cells, Cultured; Chromosome Aberrations; Chromosomes, Human; Gamma Rays; Humans; Leukocytes, Mononuclear; Marine Toxins; Mitogens; Oxazoles; Radiation Injuries | 2011 |
PP2A phosphatase suppresses function of the mesenchymal invasion regulator NEDD9.
Topics: Adaptor Proteins, Signal Transducing; Cell Line; Cell Movement; Cysteine Proteinase Inhibitors; Humans; Leupeptins; Marine Toxins; Mesoderm; Oxazoles; Phosphoproteins; Protein Isoforms; Protein Phosphatase 2; Recombinant Fusion Proteins; RNA Interference | 2012 |
The Discodermia calyx toxin calyculin a enhances cyclin D1 phosphorylation and degradation, and arrests cell cycle progression in human breast cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Culture Techniques; Cell Cycle Checkpoints; Cyclin D1; Dose-Response Relationship, Drug; Female; Humans; Marine Toxins; MCF-7 Cells; Oxazoles; Phosphorylation; Porifera; Protein Array Analysis; Proteolysis | 2011 |
Sphingosine regulates the NLRP3-inflammasome and IL-1β release from macrophages.
Topics: Animals; Blotting, Western; Carrier Proteins; Enzyme Inhibitors; Flow Cytometry; Inflammasomes; Interleukin-1beta; Macrophages, Peritoneal; Marine Toxins; Mice; Mice, Inbred C57BL; Mice, Knockout; NLR Family, Pyrin Domain-Containing 3 Protein; Okadaic Acid; Oxazoles; Peritonitis; Phosphoprotein Phosphatases; Random Allocation; Sphingosine | 2012 |
Phos-tag SDS-PAGE systems for phosphorylation profiling of proteins with a wide range of molecular masses under neutral pH conditions.
Topics: Affinity Labels; Ataxia Telangiectasia Mutated Proteins; Buffers; Cell Cycle Proteins; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; HeLa Cells; Humans; Hydrochloric Acid; Hydrogen-Ion Concentration; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Molecular Weight; Oxazoles; Phosphoproteins; Phosphorylation; Protein Serine-Threonine Kinases; Tumor Suppressor Proteins; Vimentin; Zinc | 2012 |
Calyculin A reveals serine/threonine phosphatase protein phosphatase 1 as a regulatory nodal point in canonical signal transducer and activator of transcription 3 signaling of human microvascular endothelial cells.
Topics: Carcinogens; Cell Line; CREB-Binding Protein; Endothelium; Humans; Interleukin-6; Leukemia Inhibitory Factor; Marine Toxins; Microvessels; Oxazoles; Phosphorylation; Protein Multimerization; Protein Phosphatase 1; Protein Phosphatase 2; Signal Transduction; STAT3 Transcription Factor; Transcription, Genetic | 2012 |
Phosphorylation of AIB1 at mitosis is regulated by CDK1/CYCLIN B.
Topics: Animals; CDC2 Protein Kinase; Cell Line, Tumor; Chlorocebus aethiops; Chromatin; COS Cells; Cyclin A; Cyclin B; E2F1 Transcription Factor; Flow Cytometry; HeLa Cells; Humans; Marine Toxins; Mitosis; Models, Biological; Nuclear Receptor Coactivator 3; Okadaic Acid; Oxazoles; Phosphorylation; Protein Processing, Post-Translational | 2011 |
γ-Aminobutyric acid type A (GABAA) receptor activation modulates tau phosphorylation.
Topics: Alzheimer Disease; Animals; Cell Line, Tumor; Cyclin-Dependent Kinase 5; Cytoskeleton; Enzyme Inhibitors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Humans; Marine Toxins; Mice; Naphthoquinones; Nerve Degeneration; Neuroblastoma; NIMA-Interacting Peptidylprolyl Isomerase; Oxazoles; Peptidylprolyl Isomerase; Phosphorylation; Protein Kinase Inhibitors; Protein Phosphatase 2; Purines; Rats; Receptors, GABA-A; Roscovitine; tau Proteins; Tauopathies | 2012 |
Protease activation and the signal transduction pathway regulating motility in sperm from the water strider Aquarius remigis.
Topics: Animals; Calcium; Egtazic Acid; Heteroptera; Male; MAP Kinase Signaling System; Marine Toxins; Oxazoles; Phosphorylation; Protein Kinase Inhibitors; Protein Kinases; Receptor, PAR-2; Signal Transduction; Sperm Motility; Spermatozoa; Staurosporine; Thapsigargin; Trypsin | 2012 |
Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions.
Topics: Adherens Junctions; Amides; Cell Communication; Cells, Cultured; Cytoskeleton; Endothelium, Vascular; Humans; Marine Toxins; Mechanotransduction, Cellular; Muscle Relaxants, Central; Oxazoles; Pulmonary Artery; Pyridines; Shear Strength; Vasoconstrictor Agents | 2012 |
Auxin activates the plasma membrane H+-ATPase by phosphorylation during hypocotyl elongation in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Membrane; Enzyme Activation; F-Box Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hypocotyl; Indoleacetic Acids; Leupeptins; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Proteasome Endopeptidase Complex; Proton-Translocating ATPases; Receptors, Cell Surface; Signal Transduction; Threonine; Time Factors; Transcription, Genetic | 2012 |
Characterization of the plasma membrane H+-ATPase in the liverwort Marchantia polymorpha.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Arabidopsis; Cell Membrane; Expressed Sequence Tags; Genes, Plant; Glycosides; Isoenzymes; Light; Mannose; Marchantia; Marine Toxins; Molecular Sequence Data; Osmotic Pressure; Oxazoles; Phosphorylation; Photosynthesis; Phylogeny; Plant Proteins; Protein Binding; Proton-Translocating ATPases; Sucrose; Threonine | 2012 |
Reactive oxygen species production and activation mechanism of the rice NADPH oxidase OsRbohB.
Topics: Calcium; HEK293 Cells; Humans; Ionomycin; Marine Toxins; NADPH Oxidases; Oryza; Oxazoles; Phosphorylation; Reactive Oxygen Species; Transfection | 2012 |
Deletion of Dicer in smooth muscle affects voiding pattern and reduces detrusor contractility and neuroeffector transmission.
Topics: Adenosine Triphosphate; Animals; Calcium Channels, L-Type; Calcium-Binding Proteins; Calponins; DEAD-box RNA Helicases; Desmin; Electric Stimulation; Gene Expression; Male; Marine Toxins; Mice; Microfilament Proteins; MicroRNAs; Muscle Contraction; Muscle, Smooth; Neuroeffector Junction; Oxazoles; Real-Time Polymerase Chain Reaction; Ribonuclease III; Synaptic Transmission; Tissue Culture Techniques; Urinary Bladder; Urination | 2012 |
[The involvement of actin cytoskeleton in glutoxim and molixan effect on intracellular Ca(2+)-concentration in macrophages].
Topics: Actin Cytoskeleton; Animals; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Calcium Signaling; Cytochalasin D; Cytoprotection; Drug Combinations; Immunologic Factors; Inosine; Macrophages, Peritoneal; Marine Toxins; Microscopy, Fluorescence; Oligopeptides; Oxazoles; Phalloidine; Rats; Rats, Wistar; Rhodamines; Thiazolidines | 2012 |
[The effect of glutoxim on Na+ transport in frog skin: the role of cytoskeleton].
Topics: Actin Cytoskeleton; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cytochalasin D; Disulfides; Ion Transport; Male; Marine Toxins; Microtubules; Nocodazole; Oligopeptides; Oxazoles; Patch-Clamp Techniques; Rana temporaria; Skin; Sodium; Thiazolidines | 2012 |
Calyculin A causes sensitization to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis by ROS-mediated down-regulation of cellular FLICE-inhibiting protein (c-FLIP) and by enhancing death receptor 4 mRNA stabilization.
Topics: Apoptosis; CASP8 and FADD-Like Apoptosis Regulating Protein; Cell Line, Tumor; Down-Regulation; Drug Screening Assays, Antitumor; Humans; Marine Toxins; Models, Biological; Oxazoles; Protein Phosphatase 1; Reactive Oxygen Species; Receptors, TNF-Related Apoptosis-Inducing Ligand; RNA Stability; Signal Transduction; TNF-Related Apoptosis-Inducing Ligand; Up-Regulation | 2012 |
Autophosphorylation of the C2 domain inhibits translocation of the novel protein kinase C (nPKC) Apl II.
Topics: Animals; Aplysia; Marine Toxins; Mutagenesis; Oxazoles; Phosphatidic Acids; Phosphorylation; Protein Kinase C; Protein Kinase Inhibitors; Protein Processing, Post-Translational; Protein Structure, Tertiary; Sensory Receptor Cells; Sf9 Cells | 2012 |
Relationship between cyclic AMP-dependent protein tyrosine phosphorylation and extracellular calcium during hyperactivation of boar spermatozoa.
Topics: Analysis of Variance; Animals; Calcium; Calcium Chloride; Calmodulin; Cyclic AMP; Dichlororibofuranosylbenzimidazole; Extracellular Space; Flagella; Male; Marine Toxins; Oxazoles; Phosphorylation; Protein-Tyrosine Kinases; Spermatozoa; Sus scrofa; Thionucleotides; Tyrosine | 2012 |
Cytoskeleton reorganization as an alternative mechanism of store-operated calcium entry control in neuroendocrine-differentiated cells.
Topics: Actins; Androgens; Apoptosis; Calcium; Calcium Channels; Cell Differentiation; Cell Line, Tumor; Cytochalasin D; Cytoskeleton; DNA Primers; Electrophysiology; Humans; Male; Marine Toxins; Membrane Proteins; Neoplasm Proteins; Neuroendocrine Cells; ORAI1 Protein; Oxazoles; Phenotype; Prostatic Neoplasms; Stromal Interaction Molecule 1; TRPC Cation Channels | 2012 |
Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases.
Topics: Apoptosis; Blotting, Western; Calcium; Calcium Channel Blockers; Cell Division; Cell Line; Cell Proliferation; Cyclin D1; Dose-Response Relationship, Drug; Epithelial Cells; Female; Fibroblasts; Fluorescent Antibody Technique; Humans; Marine Toxins; MCF-7 Cells; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation | 2012 |
Characterization of Al-responsive citrate excretion and citrate-transporting MATEs in Eucalyptus camaldulensis.
Topics: Aluminum; Amino Acid Sequence; Citric Acid; Cloning, Molecular; Cyclosporine; Eucalyptus; Marine Toxins; Molecular Sequence Data; Organic Cation Transport Proteins; Oxazoles; Plant Proteins; Plant Roots; Polymerase Chain Reaction; Protein Kinase Inhibitors | 2013 |
Regulation of fowl sperm motility: evidence for the indirect, but not direct, involvement of dynein-ATPase activity on the reversible temperature-dependent immobilization.
Topics: Animals; Calcium; Cell Membrane; Chickens; Dyneins; Enzyme Inhibitors; Male; Marine Toxins; Membrane Fluidity; Oxazoles; Protein Phosphatase 1; Protein Phosphatase 2; Sperm Motility; Spermatozoa; Temperature | 2013 |
AMPK activity is regulated by calcium-mediated protein phosphatase 2A activity.
Topics: AMP-Activated Protein Kinases; Animals; Caffeine; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Marine Toxins; Oxazoles; Protein Kinase Inhibitors; Protein Phosphatase 2; RNA, Small Interfering; Structure-Activity Relationship; Swine | 2013 |
The effect of calyculin A on the dephosphorylation of the histone γ-H2AX after formation of X-ray-induced DNA double-strand breaks in human blood lymphocytes.
Topics: Biological Assay; Cells, Cultured; DNA; DNA Damage; Histones; Humans; Lymphocytes; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Radiation Dosage; X-Rays | 2013 |
Phosphorylation of threonine 333 regulates trafficking of the human sst5 somatostatin receptor.
Topics: Amino Acid Sequence; Antibody Specificity; Biocatalysis; Endocytosis; G-Protein-Coupled Receptor Kinase 2; HEK293 Cells; Humans; Marine Toxins; Molecular Sequence Data; Oxazoles; Phosphorylation; Phosphothreonine; Protein Phosphatase 1; Protein Transport; Receptors, Somatostatin | 2013 |
Reactivation of desensitized formyl peptide receptors by platelet activating factor: a novel receptor cross talk mechanism regulating neutrophil superoxide anion production.
Topics: Actins; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cells, Cultured; Cyclosporine; Cytochalasin B; Cytoskeleton; Gelsolin; Humans; Marine Toxins; NADPH Oxidases; Neutrophils; Oligopeptides; Oxazoles; Peptide Fragments; Platelet Activating Factor; Receptors, Formyl Peptide; Superoxides; Thiazolidines; Triazoles | 2013 |
Oxidative stress induces inactivation of protein phosphatase 2A, promoting proinflammatory NF-κB in aged rat kidney.
Topics: Aging; Animals; HEK293 Cells; Humans; Kidney; Male; Marine Toxins; Mice; Mice, Inbred C57BL; NF-kappa B; Oxazoles; Oxidative Stress; Protein Phosphatase 2; Protein-Tyrosine Kinases; Rats; Rats, Inbred F344 | 2013 |
Differential effects of phosphatase inhibitors on the calcium homeostasis and migration of HaCaT keratinocytes.
Topics: Calcium Signaling; Cell Line; Cell Movement; Cells, Cultured; Enzyme Inhibitors; Homeostasis; Humans; Keratinocytes; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases | 2013 |
Dual role of cyclic GMP in cardiac cell survival.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Carbazoles; Cell Adhesion Molecules; Cell Line; Cell Survival; Cyclic GMP; Fluorescence; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Insulin; Marine Toxins; Microfilament Proteins; Myocytes, Cardiac; Oxazoles; Phosphoproteins; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins c-akt; Rats | 2013 |
Effects of adhesion dynamics and substrate compliance on the shape and motility of crawling cells.
Topics: Actins; Cell Adhesion; Cell Movement; Cell Shape; Cells, Cultured; Elastic Modulus; Heterocyclic Compounds, 4 or More Rings; Humans; Keratinocytes; Marine Toxins; Models, Biological; Myosins; Oligopeptides; Oxazoles; Surface Properties | 2013 |
Suitability of scoring PCC rings and fragments for dose assessment after high-dose exposures to ionizing radiation.
Topics: Cells, Cultured; Chromosome Aberrations; Chromosomes; Dose-Response Relationship, Radiation; Humans; Lymphocytes; Marine Toxins; Metaphase; Mitosis; Oxazoles; Radiation Dosage; Radiation, Ionizing; Ring Chromosomes | 2013 |
Pinched-flow hydrodynamic stretching of single-cells.
Topics: Biomechanical Phenomena; Cell Size; HeLa Cells; Humans; Hydrodynamics; Jurkat Cells; Marine Toxins; MCF-7 Cells; Microfluidic Analytical Techniques; Oxazoles; Single-Cell Analysis; Tetradecanoylphorbol Acetate | 2013 |
Probing cell traction forces in confined microenvironments.
Topics: Animals; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Dimethylpolysiloxanes; Heterocyclic Compounds, 4 or More Rings; Humans; Marine Toxins; Mice; Microfluidic Analytical Techniques; Myosins; NIH 3T3 Cells; Oxazoles | 2013 |
Inhibition of PP2A activity confers a TRAIL-sensitive phenotype during malignant transformation.
Topics: Antigens, Polyomavirus Transforming; Apoptosis; Cell Line; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epithelial Cells; Gene Expression Regulation; Humans; Male; Marine Toxins; Okadaic Acid; Oxazoles; Phenotype; Protein Phosphatase 2; RNA, Small Interfering; Telomerase; TNF-Related Apoptosis-Inducing Ligand | 2014 |
Cellular traction stresses mediate extracellular matrix degradation by invadopodia.
Topics: Acrylic Resins; Actomyosin; Cell Line, Tumor; Extracellular Matrix; Fibronectins; Humans; Marine Toxins; Microscopy; Oxazoles; Pseudopodia; Stress, Mechanical | 2014 |
A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide.
Topics: Actin Cytoskeleton; Adenosine Triphosphate; Antineoplastic Agents; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cyclosporine; Enzyme Inhibitors; Humans; Marine Toxins; NADPH Oxidases; Neutrophil Activation; Neutrophils; Oxazoles; Phosphoprotein Phosphatases; Purinergic P2Y Receptor Antagonists; Receptors, Formyl Peptide; Receptors, Purinergic P2Y2; Signal Transduction; Superoxides; Suramin; Thiazolidines | 2014 |
Ca2+-activated reactive oxygen species production by Arabidopsis RbohH and RbohJ is essential for proper pollen tube tip growth.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Calcium; Ionomycin; Marine Toxins; Molecular Sequence Data; Mutation; NADPH Oxidases; Oxazoles; Pollen Tube; Reactive Oxygen Species; Sequence Homology, Amino Acid | 2014 |
Channel-anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin.
Topics: Animals; Calmodulin; Casein Kinase II; CHO Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Humans; KCNQ2 Potassium Channel; Marine Toxins; Mutation; Neurons; Oxazoles; Protein Phosphatase 1; Protein Structure, Tertiary; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion | 2014 |
Inhibitory interactions between phosphorylation sites in the C terminus of α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid-type glutamate receptor GluA1 subunits.
Topics: Animals; Binding Sites; Blotting, Western; Calcium; Calcium Channels; Cyclic AMP-Dependent Protein Kinases; HEK293 Cells; Hippocampus; Humans; Male; Marine Toxins; Membrane Potentials; Mice; Mice, Inbred C57BL; Neurons; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C; Protein Phosphatase 1; Protein Phosphatase 2; Protein Subunits; Receptors, AMPA; Serine; Threonine | 2014 |
Berberine attenuates axonal transport impairment and axonopathy induced by Calyculin A in N2a cells.
Topics: Alzheimer Disease; Animals; Axonal Transport; Axons; Berberine; Cell Line, Tumor; Cell Shape; Malondialdehyde; Marine Toxins; Mice; Neurons; Oxazoles; Oxidative Stress; Phosphorylase b; Phosphorylation; Superoxide Dismutase; tau Proteins | 2014 |
A novel parameter, cell-cycle progression index, for radiation dose absorbed estimation in the premature chromosome condensation assay.
Topics: Biological Assay; Carcinogens; Cell Cycle; Cells, Cultured; Chromosomes, Human; Dose-Response Relationship, Radiation; Female; Humans; Lymphocytes; Male; Marine Toxins; Oxazoles; Radiation Injuries; X-Rays | 2014 |
Traction force microscopy in rapidly moving cells reveals separate roles for ROCK and MLCK in the mechanics of retraction.
Topics: Animals; Biomechanical Phenomena; Calcimycin; Cell Adhesion; Cell Movement; Cell Polarity; Cells, Cultured; Epithelial Cells; Fish Proteins; Marine Toxins; Microscopy, Atomic Force; Models, Biological; Myosin Type II; Myosin-Light-Chain Kinase; Oxazoles; Poecilia; rho-Associated Kinases; Stress, Mechanical; Traction | 2014 |
Myosin IIb controls actin dynamics underlying the dendritic spine maturation.
Topics: Actin Cytoskeleton; Actins; Animals; Cells, Cultured; Dendritic Spines; Embryo, Mammalian; Enzyme Inhibitors; Green Fluorescent Proteins; Heterocyclic Compounds, 4 or More Rings; Hippocampus; Luminescent Proteins; Marine Toxins; Microtubule-Associated Proteins; Models, Biological; Neurons; Nonmuscle Myosin Type IIB; Oxazoles; Rats; Rats, Wistar; Red Fluorescent Protein; RNA, Small Interfering; Time Factors | 2014 |
Inhibition of protein phosphatase 2A (PP2A) prevents Mcl-1 protein dephosphorylation at the Thr-163/Ser-159 phosphodegron, dramatically reducing expression in Mcl-1-amplified lymphoma cells.
Topics: Binding Sites; Burkitt Lymphoma; Cell Line, Tumor; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression; Gene Knockdown Techniques; Humans; MAP Kinase Signaling System; Marine Toxins; Myeloid Cell Leukemia Sequence 1 Protein; Okadaic Acid; Oxazoles; Phosphorylation; Protein Phosphatase 2; Proteolysis; Serine; Tetradecanoylphorbol Acetate; Threonine | 2014 |
Calyculin biogenesis from a pyrophosphate protoxin produced by a sponge symbiont.
Topics: Animals; Antineoplastic Agents; Diphosphates; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Leukemia; Marine Toxins; Metagenome; Mice; Molecular Sequence Data; Multigene Family; Organophosphates; Oxazoles; Phosphorylation; Phosphotransferases; Phylogeny; Polyketide Synthases; Porifera; RNA, Ribosomal, 16S; Symbiosis | 2014 |
CaMKII protects MKP-1 from proteasome degradation in endothelial cells.
Topics: Animals; Aorta; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Proliferation; Cells, Cultured; DNA; Dual Specificity Phosphatase 1; Endothelial Cells; Enzyme Inhibitors; Insulin; Leupeptins; MAP Kinase Signaling System; Marine Toxins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxazoles; Phosphorothioate Oligonucleotides; Phosphorylation; Proteasome Endopeptidase Complex; Protein Binding; Proto-Oncogene Proteins c-raf; Rats | 2014 |
Natural products: Sponge symbionts play defense.
Topics: Animals; Diphosphates; Humans; Marine Toxins; Oxazoles; Porifera | 2014 |
Vascular O-GlcNAcylation augments reactivity to constrictor stimuli by prolonging phosphorylated levels of the myosin light chain.
Topics: Acetylglucosamine; Acylation; Aminoimidazole Carboxamide; Animals; Aorta, Thoracic; Azepines; beta-N-Acetylhexosaminidases; Blotting, Western; Enzyme Inhibitors; Hypoglycemic Agents; Male; Marine Toxins; Muscle, Smooth, Vascular; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oxazoles; Oximes; Phenylcarbamates; Phenylephrine; Phosphorylation; Protein Processing, Post-Translational; Rats, Wistar; Ribonucleotides; Vasoconstriction; Vasoconstrictor Agents | 2014 |
High glucose dephosphorylates serine 46 and inhibits p53 apoptotic activity.
Topics: Apoptosis; Cell Line, Tumor; Cell Nucleus; Cisplatin; Doxorubicin; Drug Interactions; Glucose; HCT116 Cells; Humans; Marine Toxins; Neoplasms; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Serine; Transcriptional Activation; Transfection; Tumor Suppressor Protein p53 | 2014 |
The natural tumorcide Manumycin-A targets protein phosphatase 1α and reduces hydrogen peroxide to induce lymphoma apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; Humans; Hydrogen Peroxide; Jurkat Cells; K562 Cells; Lymphoma; MAP Kinase Kinase Kinases; Marine Toxins; Membrane Potential, Mitochondrial; Mice; Oxazoles; Phosphorylation; Polyenes; Polyunsaturated Alkamides; Protein Phosphatase 1; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Vanadates | 2015 |
Compressive stress induces dephosphorylation of the myosin regulatory light chain via RhoA phosphorylation by the adenylyl cyclase/protein kinase A signaling pathway.
Topics: Actin Cytoskeleton; Adenylyl Cyclases; Animals; Cell Line; Compressive Strength; Cyclic AMP-Dependent Protein Kinases; Marine Toxins; Mice; Myosin Light Chains; Myosin-Light-Chain Kinase; Myosin-Light-Chain Phosphatase; Oxazoles; Phosphorylation; rho-Associated Kinases; rhoA GTP-Binding Protein; RNA Interference; RNA, Small Interfering; Signal Transduction | 2015 |
Distinct segment-specific functions of calyculin A-sensitive protein phosphatases in the regulation of cAMP-triggered events in ejaculated bull spermatozoa.
Topics: Acrosome Reaction; Animals; Blotting, Western; Cattle; Cell Movement; Cyclic AMP; Electrophoresis, Polyacrylamide Gel; Embryo Culture Techniques; Flagella; Fluorescent Antibody Technique, Indirect; In Vitro Techniques; Male; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Spermatozoa | 2015 |
LRRK2 dephosphorylation increases its ubiquitination.
Topics: 14-3-3 Proteins; Amino Acid Substitution; Animals; Enzyme Inhibitors; HEK293 Cells; Humans; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; Marine Toxins; Mice; Mutation, Missense; Oxazoles; Phosphorylation; Protein Serine-Threonine Kinases; Ubiquitination | 2015 |
Splenic retention of Plasmodium falciparum gametocytes to block the transmission of malaria.
Topics: Animals; Antimalarials; Automation; Enzyme Inhibitors; Erythrocyte Count; Erythrocytes; Filtration; Flow Cytometry; Image Processing, Computer-Assisted; Macrophages; Malaria, Falciparum; Marine Toxins; Mice; Microfluidic Analytical Techniques; Microspheres; Models, Biological; Oxazoles; Parasite Egg Count; Plasmodium falciparum; Spleen | 2015 |
Phosphoproteomic Analysis Using the WW and FHA Domains as Biological Filters.
Topics: 14-3-3 Proteins; Amino Acid Sequence; Cell Extracts; Chromatography, Affinity; Colforsin; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation; HeLa Cells; Humans; Marine Toxins; Molecular Sequence Annotation; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphoproteins; Phosphorylation; Protein Structure, Tertiary; Proteomics; Signal Transduction | 2015 |
Histone Deacetylase 3 and 4 Complex Stimulates the Transcriptional Activity of the Mineralocorticoid Receptor.
Topics: Acetylation; Cyclic AMP-Dependent Protein Kinases; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Marine Toxins; Oxazoles; Phosphoprotein Phosphatases; Promoter Regions, Genetic; Receptors, Mineralocorticoid; Repressor Proteins; RNA, Small Interfering; Transcription, Genetic | 2015 |
TSC2 mediates hyperosmotic stress-induced inactivation of mTORC1.
Topics: Animals; Cell Line; Humans; Lysosomes; Marine Toxins; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Monomeric GTP-Binding Proteins; Multiprotein Complexes; Osmotic Pressure; Oxazoles; Phosphoprotein Phosphatases; Proto-Oncogene Proteins c-akt; Ribosomal Protein S6 Kinases; Signal Transduction; Stress, Physiological; TOR Serine-Threonine Kinases; Tuberous Sclerosis Complex 2 Protein; Tumor Suppressor Proteins | 2015 |
Combination of zoledronic acid and serine/threonine phosphatase inhibitors induces synergistic cytotoxicity and apoptosis in human breast cancer cells via inhibition of PI3K/Akt pathway.
Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Diphosphonates; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Inhibitors; Female; Humans; Imidazoles; Marine Toxins; MCF-7 Cells; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Proto-Oncogene Proteins c-akt; Signal Transduction; Zoledronic Acid | 2016 |
Inhibition of cell adhesion by phosphorylated Ezrin/Radixin/Moesin.
Topics: Cell Adhesion; Cell Line; Cell Membrane; Cell Shape; Cytoskeletal Proteins; Cytoskeleton; Humans; Marine Toxins; Membrane Proteins; Microfilament Proteins; Oxazoles; Phosphorylation | 2015 |
Mitotic phosphatase activity is required for MCC maintenance during the spindle checkpoint.
Topics: Anaphase; Anaphase-Promoting Complex-Cyclosome; CDC2 Protein Kinase; Cdc20 Proteins; Chromosomes; Cyclin A; Cyclin B; Cyclin-Dependent Kinases; Enzyme Inhibitors; Gene Expression Regulation; HeLa Cells; Humans; Isoenzymes; M Phase Cell Cycle Checkpoints; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Proteolysis; Securin; Signal Transduction; Spindle Apparatus | 2016 |
Ceramide inhibits PKCθ by regulating its phosphorylation and translocation to lipid rafts in Jurkat cells.
Topics: Cell Proliferation; Ceramides; fas Receptor; Humans; Jurkat Cells; Lymphocyte Activation; Marine Toxins; Membrane Microdomains; Okadaic Acid; Oxazoles; Phosphorylation; Protein Kinase C-theta; Protein Transport; Signal Transduction; Sphingomyelin Phosphodiesterase; T-Lymphocytes; Tetradecanoylphorbol Acetate | 2016 |
Structure of Saccharomyces cerevisiae Rtr1 reveals an active site for an atypical phosphatase.
Topics: Amino Acid Sequence; Binding Sites; Biocatalysis; Carrier Proteins; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Hymecromone; Kinetics; Marine Toxins; Metals; Models, Molecular; Mutation; Oxazoles; Phosphoprotein Phosphatases; Protein Domains; Protein Structure, Secondary; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Sulfates; Transcription Factors | 2016 |
Identification of Phosphorylation Sites Regulating sst3 Somatostatin Receptor Trafficking.
Topics: Amino Acid Sequence; Biocatalysis; Down-Regulation; G-Protein-Coupled Receptor Kinase 2; G-Protein-Coupled Receptor Kinase 3; HEK293 Cells; Humans; Marine Toxins; Membrane Potentials; Mutant Proteins; Oxazoles; Phosphoprotein Phosphatases; Phosphorylation; Protein Transport; Receptors, Somatostatin | 2016 |
Selective inhibition of the kinase DYRK1A by targeting its folding process.
Topics: Amino Acid Sequence; Animals; Biological Assay; Biomarkers; Cantharidin; Dyrk Kinases; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; HEK293 Cells; Humans; Marine Toxins; Molecular Sequence Data; Okadaic Acid; Oxazoles; Phosphorylation; Plasmids; Protein Folding; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Recombinant Proteins; Sequence Alignment; Thiazoles; Transfection; Xenopus laevis | 2016 |
CaMKII prevents spontaneous acrosomal exocytosis in sperm through induction of actin polymerization.
Topics: Acrosome; Acrosome Reaction; Actin Cytoskeleton; Actins; Animals; Calcimycin; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cattle; Enzyme Activation; Exocytosis; Gelsolin; Hydrogen Peroxide; Male; Marine Toxins; Oxazoles; Peptide Fragments; Phospholipase D; Polymerization; Sperm Capacitation; Spermatozoa | 2016 |
Phosphatase inhibition increases AQP2 accumulation in the rat IMCD apical plasma membrane.
Topics: Animals; Aquaporin 2; Cell Membrane; Enzyme Inhibitors; Kidney Medulla; Marine Toxins; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Rats; Rats, Sprague-Dawley; Tacrolimus | 2016 |
Dose response of multiple parameters for calyculin A-induced premature chromosome condensation in human peripheral blood lymphocytes exposed to high doses of cobalt-60 gamma-rays.
Topics: Adult; Carcinogens; Cells, Cultured; Chromosomes; Cobalt Radioisotopes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Lymphocytes; Male; Marine Toxins; Micronuclei, Chromosome-Defective; Oxazoles | 2016 |
Standardization of CalyculinA induced PCC assay and its advantages over Okadaic acid PCC assay in Biodosimetry applications.
Topics: Carcinogens; Chromosome Aberrations; Dose-Response Relationship, Drug; Humans; Lymphocytes; Marine Toxins; Okadaic Acid; Oxazoles; Radiometry | 2016 |
Stimulation of Suicidal Erythrocyte Death by Phosphatase Inhibitor Calyculin A.
Topics: Calcium; Cytosol; Enzyme Inhibitors; Eryptosis; Humans; Marine Toxins; Oxazoles; Phosphatidylserines; Phosphoric Monoester Hydrolases; Scattering, Radiation | 2016 |
Translocation of Tektin 3 to the equatorial segment of heads in bull spermatozoa exposed to dibutyryl cAMP and calyculin A.
Topics: Acrosome; Acrosome Reaction; Animals; Bucladesine; Cattle; Male; Marine Toxins; Microtubule Proteins; Oxazoles; Protein Transport | 2017 |
Human cytomegalovirus phosphoproteins are hypophosphorylated and intrinsically disordered.
Topics: Cytomegalovirus; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Phosphoproteins; Phosphorylation; Protein Processing, Post-Translational; Viral Matrix Proteins | 2017 |
Cordycepin inhibits migration of human glioblastoma cells by affecting lysosomal degradation and protein phosphatase activation.
Topics: Ammonium Chloride; Animals; Antineoplastic Agents; Apoptosis; Brain Neoplasms; Cell Line, Tumor; Cell Movement; Deoxyadenosines; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lysosomes; Marine Toxins; Mice, Nude; Neoplasm Proteins; Okadaic Acid; Oxazoles; Phosphoprotein Phosphatases; Proteolysis; Tumor Burden; Xenograft Model Antitumor Assays | 2017 |
Liguzinediol Enhances the Inotropic Effect of Rat Hearts via Inhibition of Protein Phosphatase (PP1 and PP2A) Activities.
Topics: Animals; Calcium Channel Agonists; Cardiotonic Agents; Enzyme Inhibitors; Heart; Male; Marine Toxins; Organ Culture Techniques; Oxazoles; Protein Phosphatase 1; Protein Phosphatase 2; Pyrazines; Rats; Rats, Sprague-Dawley; Sarcoplasmic Reticulum Calcium-Transporting ATPases | 2017 |
Interplay of myosin phosphatase and protein phosphatase-2A in the regulation of endothelial nitric-oxide synthase phosphorylation and nitric oxide production.
Topics: Animals; Catechin; Cattle; Cell Line; Electric Impedance; Enzyme Activation; Gene Silencing; Human Umbilical Vein Endothelial Cells; Humans; Marine Toxins; Models, Biological; Myosin-Light-Chain Phosphatase; Nitric Oxide; Nitric Oxide Synthase Type III; Oxazoles; Phosphorylation; Phosphothreonine; Protein Kinase C; Protein Phosphatase 2; Pulmonary Artery; Rabbits; RNA, Small Interfering; Tetradecanoylphorbol Acetate | 2017 |
Cellular orientation is guided by strain gradients.
Topics: Anisotropy; Bioengineering; Biomechanical Phenomena; Cell Polarity; Cellular Microenvironment; Equipment Design; Fibroblasts; Focal Adhesions; Heterocyclic Compounds, 4 or More Rings; Humans; Marine Toxins; Mechanotransduction, Cellular; Myosin Type II; Oxazoles; Stress, Mechanical | 2017 |
The Phosphatase Inhibitor Calyculin-A Impairs Clot Retraction, Platelet Activation, and Thrombin Generation.
Topics: Blood Platelets; Enzyme Inhibitors; Female; Fibrinolysis; Flow Cytometry; Humans; Male; Marine Toxins; Oxazoles; Platelet Activation | 2017 |
Phosphorylation-dependent signaling controls degradation of DNA mismatch repair protein PMS2.
Topics: Blotting, Western; Enzyme Inhibitors; HEK293 Cells; Humans; Marine Toxins; Mismatch Repair Endonuclease PMS2; Mutation; MutL Protein Homolog 1; MutL Proteins; Niacinamide; Oxazoles; Phenylurea Compounds; Phosphorylation; Proteolysis; Serine; Signal Transduction; Sorafenib; Threonine | 2017 |
Rac1 modulates G-protein-coupled receptor-induced bronchial smooth muscle contraction.
Topics: Animals; Bronchi; Carbachol; Endothelin-1; Male; Marine Toxins; Muscle Contraction; Muscle, Smooth; Myosin Light Chains; Oxazoles; Phorbol 12,13-Dibutyrate; Phosphorylation; Potassium; Protein Phosphatase 1; rac1 GTP-Binding Protein; Rats; Rats, Wistar; Receptors, G-Protein-Coupled | 2018 |
Protein Phosphatase 1 dephosphorylates TDP-43 and suppresses its function in tau exon 10 inclusion.
Topics: Alternative Splicing; DNA-Binding Proteins; Exons; HEK293 Cells; HeLa Cells; Humans; Marine Toxins; Okadaic Acid; Oxazoles; Phosphorylation; Protein Phosphatase 1; Protein Phosphatase 2; Serine; tau Proteins; Up-Regulation | 2018 |
Transient PP2A inhibition alleviates normal tissue stem cell susceptibility to cell death during radiotherapy.
Topics: Animals; Apoptosis; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Cells, Cultured; DNA Repair; Enzyme Inhibitors; Hematopoietic Stem Cells; Humans; Male; Marine Toxins; Mice; Mice, Inbred C57BL; Mouse Embryonic Stem Cells; Neural Stem Cells; Oxazoles; Protein Phosphatase 2; Proto-Oncogene Proteins c-akt; Radiation Tolerance; Signal Transduction; Stem Cells; Time Factors; Tissue Culture Techniques | 2018 |
Biosynthetic Insights of Calyculin- and Misakinolide-Type Compounds in "Candidatus Entotheonella sp."
Topics: Animals; Biochemistry; Biological Products; Biosynthetic Pathways; Computational Biology; Macrolides; Marine Toxins; Metagenome; Metagenomics; Multigene Family; Oxazoles; Peptide Biosynthesis, Nucleic Acid-Independent; Polyketides; Porifera; Symbiosis | 2018 |
Therapeutic Chemical Screen Identifies Phosphatase Inhibitors to Reconstitute PKB Phosphorylation and Cardiac Contractility in ILK-Deficient Zebrafish.
Topics: Animals; Apoptosis; Cardiomyopathies; Disease Models, Animal; Enzyme Inhibitors; Humans; Marine Toxins; Myocardial Contraction; Okadaic Acid; Oxazoles; Phosphoric Monoester Hydrolases; Phosphorylation; Protein Serine-Threonine Kinases; Signal Transduction; Zebrafish; Zebrafish Proteins | 2018 |
Photoelasticity-based evaluation of cellular contractile force for phenotypic discrimination of vascular smooth muscle cells.
Topics: Actin Cytoskeleton; Amides; Animals; Cells, Cultured; Elasticity; Fluorescence; Marine Toxins; Microscopy, Fluorescence; Muscle Contraction; Muscle, Smooth, Vascular; Oxazoles; Phenotype; Pyridines; Swine | 2019 |
Actomyosin contractility-dependent matrix stretch and recoil induces rapid cell migration.
Topics: Acrylic Resins; Actomyosin; Amides; Animals; Biocompatible Materials; Cell Line, Tumor; Cell Movement; Dextrans; Elastic Modulus; Extracellular Matrix; Fibroblasts; Heterocyclic Compounds, 4 or More Rings; Humans; Intravital Microscopy; Marine Toxins; Materials Testing; Methacrylates; Mice; Microscopy, Confocal; NIH 3T3 Cells; Oxazoles; Pyridines; Time-Lapse Imaging | 2019 |
High-frequency microrheology in 3D reveals mismatch between cytoskeletal and extracellular matrix mechanics.
Topics: Actomyosin; Amides; Cell Culture Techniques; Cell Movement; Cytoskeleton; Extracellular Matrix; Heterocyclic Compounds, 4 or More Rings; Humans; Hydrogels; Laminin; Marine Toxins; MCF-7 Cells; Mechanotransduction, Cellular; Oxazoles; Pyridines; Rheology; Viscosity | 2019 |
The role of phosphorylation in the elasticity of the tethers that connect telomeres of separating anaphase chromosomes.
Topics: Anaphase; Animals; Chromosomes; Diptera; Elasticity; Enzyme Inhibitors; Marine Toxins; Oxazoles; Phosphorylation; Telomere | 2020 |
A Simplified Calyculin A-Induced Premature Chromosome Condensation (PCC) Protocol for the Biodosimetric Analysis of High-Dose Exposure to Gamma Radiation.
Topics: Adult; Chromosome Aberrations; Dose-Response Relationship, Radiation; Gamma Rays; Humans; Male; Marine Toxins; Middle Aged; Oxazoles; Radiometry | 2020 |
Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD.
Topics: Animals; Animals, Newborn; Carcinogens; Cells, Cultured; Cerebral Cortex; Intracellular Signaling Peptides and Proteins; Marine Toxins; Neurons; Neuroprotective Agents; Oxazoles; Oxidative Stress; Phosphorylation; Protein Phosphatase 2; Rats; tau Proteins | 2021 |
A faster and easier biodosimetry method based on calyculin A-induced premature chromosome condensation (PCC) by scoring excess objects.
Topics: Calibration; Chromosomes, Human; Dose-Response Relationship, Radiation; Environmental Exposure; Humans; Marine Toxins; Mass Casualty Incidents; Models, Biological; Oxazoles; Pilot Projects; Radiation Dosage; Radioactive Hazard Release; Radiometry; Triage | 2020 |
PP1/PP2A phosphatase inhibition-induced metaplasticity in protein synthesis blocker-treated hippocampal slices: LTP and LTD, or There and Back again.
Topics: Animals; Anisomycin; CA1 Region, Hippocampal; Cycloheximide; Electric Stimulation; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Long-Term Potentiation; Long-Term Synaptic Depression; Male; Marine Toxins; Neuronal Plasticity; Nitric Oxide; Okadaic Acid; Oxazoles; Protein Phosphatase 1; Protein Phosphatase 2; Protein Synthesis Inhibitors; Rats; Rats, Wistar | 2021 |
Evaluation of Calyculin A Effect on γH2AX/53BP1 Focus Formation and Apoptosis in Human Umbilical Cord Blood Lymphocytes.
Topics: Apoptosis; DNA Damage; DNA Repair; Dose-Response Relationship, Radiation; Fetal Blood; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lymphocytes; Marine Toxins; Microscopy, Fluorescence; Oxazoles; Phosphorylation; Tumor Suppressor p53-Binding Protein 1 | 2021 |
Effects of Calyculin a on the Motility and Protein Phosphorylation in Frozen-Thawed Bull Spermatozoa.
Topics: Animals; Cattle; Cryopreservation; Cyclic AMP; Male; Marine Toxins; Oxazoles; Phosphorylation; Sperm Motility; Spermatozoa | 2021 |