oxazoles has been researched along with acivicin in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 78 (92.86) | 18.7374 |
| 1990's | 5 (5.95) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (1.19) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lau, SS; Monks, TJ | 1 |
| Cao, LQ; Chance, WT; Fischer, JE | 1 |
| Christopherson, RI; Lyons, SD; Sant, ME | 1 |
| Bhaduri, A; Mukherjee, T; Roy, K | 1 |
| Bailey, H; Earhart, RH; McGovren, JP; Williams, MG | 1 |
| Ardalan, B; Chandrasekaran, B; Hrishikeshavan, HJ | 1 |
| Prajda, N | 1 |
| Ikegami, T; Natsumeda, Y; Weber, G | 1 |
| Ardalan, B; Deas, M; Jayaram, HN; Johnson, RK | 1 |
| Einspahr, FJ; McGovren, JP; Piercey, MF; Schreur, PJ; Tang, AH; VonVoigtlander, PF; Williams, MG | 1 |
| Futami, H; Irino, S; Shiotani, T; Yamaji, Y; Yamauchi, N | 1 |
| Chitneni, SR; Moore, JO; Nichols, KE; Weinberg, JB | 1 |
| Davis, TE; Earhart, RH; Faraggi, D; Khandekar, JD; Schinella, RA | 1 |
| Capraro, MA; Hughey, RP | 1 |
| Burk, RF; Hill, KE; Von Hoff, DD | 1 |
| Sastrasinh, M; Sastrasinh, S | 2 |
| Curthoys, NP; Scott, RD | 1 |
| Harris, C; Juchau, MR; Stark, KL | 1 |
| Davis, ME | 1 |
| Aoki, T; Oya, H | 2 |
| Ryan, TM; Zoutendam, PH | 1 |
| Eisenhauer, E; Maksymiuk, A; Maroun, JA; Pater, J; Stewart, DJ; Young, V | 1 |
| Cao, L; Chance, WT; Fischer, JE; Foley-Nelson, T; Nelson, JL | 1 |
| Cao, L; Chance, WT; Fischer, JE | 1 |
| Capizzi, RL; Craig, JB; Powell, BL; Richards, F | 1 |
| Carbone, PP; Davis, TE; Earle, JD; Elson, PJ; Glover, DJ; Hahn, RG; Kvols, LK; Trump, DL; Vogl, SE | 1 |
| Cao, L; Chance, WT; Fischer, JE; Kim, MW; Nelson, JL | 1 |
| Emrani, J; Hashimoto, Y; Ikegami, T; Natsumeda, Y; Prajda, N; Reardon, MA; Szondy, S; Weber, G | 1 |
| Huber, KR; Roberts, J; Rosenfeld, H | 1 |
| Eisenhauer, EA; Fields, AL; Maroun, JA; Walde, PL | 1 |
| Birch, R; Greco, A; Johnson, R; Kramer, BS; Prestridge, K | 1 |
| Chang, YC; Falkson, G; Knuiman, MW; Pandya, KJ; Skeel, RT; Willson, JK; Wolter, JM | 1 |
| Booth, BW; Budman, D; Ellison, RR; Khojasteh, A; Korzun, AH; Weiss, RB; Wood, W | 1 |
| Borden, EC; Falkson, G; Simson, IW; Vorobiof, DA | 1 |
| Huber, KR; Mayer, EP; Mitchell, DF; Roberts, J | 1 |
| Blessing, JA; Buchsbaum, HJ; DiSaia, PJ; McGuire, WP | 1 |
| Martin, DG; Mizsak, SA; Nielsen, JW | 1 |
| Adolphson, CC; Ajani, JA; Barlogie, B; Bedikian, AY; Bodey, GP; Korinek, J; Stroehlein, JR | 1 |
| Christopherson, RI; Kemp, AJ; Lyons, SD | 1 |
| Achleitner, E; Lui, MS; Weber, G | 1 |
| Gerok, W; Häussinger, D; Holstege, A; Pausch, J; Rasenack, J | 1 |
| Ardalan, B; Belt, RJ; Benjamin, RS; McGovren, JP; Ohnuma, T; Pratt, EA; Taylor, SA | 1 |
| Earhart, RH; Neil, GL | 1 |
| Aoki, T; Eble, JN; Glover, JL; Sebolt, JS; Weber, G | 1 |
| Kostyniak, PJ; Mulder, KM | 1 |
| McGovren, JP; Roach, BL; Robins, RH; Williams, MG | 1 |
| Allen, L; Meck, R; Yunis, A | 1 |
| Ellis, WW; Meck, RA; Reed, DJ | 1 |
| Allen, LM; Thornthwaite, JT | 1 |
| Allen, LM; Corrigan, MV; Meinking, T | 1 |
| Gardell, SJ; Tate, SS | 1 |
| Kozak, EM; Tate, SS | 1 |
| Curthoys, NP; Shapiro, RA | 1 |
| Dass, PD; Welbourne, TC | 1 |
| Curthoys, NP; Reed, DJ; Schasteen, CS | 1 |
| Aoki, T; Burt, ME; Denton, JE; Faderan, MA; Lui, MS; Prajda, N; Reardon, MA; Sebolt, J; Weber, G; Zhen, YS | 1 |
| Bhalla, K; Deitch, A; Grant, S; Nayak, R | 1 |
| Elliott, WL; Faderan, MA; Liepnieks, JJ; Lui, MS; Natsumeda, Y; Weber, G | 1 |
| Carl, PL; Chakravarty, PK; Katzenellenbogen, JA; Weber, MJ | 1 |
| Alonso, MT; Leyland-Jones, B; O'Dwyer, PJ | 1 |
| Cripps, C; Eisenhauer, E; Fields, AL; Maroun, JA; Pater, JL; Stewart, DJ | 1 |
| Belt, RJ; Haas, CD; Hoogstraten, B; Joseph, U; Taylor, S | 1 |
| Bittner, G; Fischer, PH; Pamukcu, R; Willson, JK | 1 |
| Ardalan, B; Jayaram, HN; Johnson, RK | 1 |
| Lui, MS; Weber, G; Zhen, YS | 1 |
| Keppler, DO; Leube, K | 1 |
| Bodey, G; Fleishman, G; Murphy, WK; Yap, HY | 1 |
| Bower, SG; Tso, JY; Zalkin, H | 1 |
| Bruno, S; McGovren, JP; Neil, GL; Penta, J; Poster, DS | 1 |
| Aoki, T; Denton, JE; Lui, MS; Sebolt, J; Weber, G | 1 |
| Aoki, T; Sebolt, J; Weber, G | 1 |
| Elfring, GL; McGovren, JP; Poplack, DG; Smith, RB; Soares, N; Stewart, JC; Von Hoff, DD; Wood, JH | 1 |
| Kufe, DW; McGovren, JP; Schade, D; Weiss, GR | 1 |
| Cooney, DA; Jayaram, HN; Kensler, TW | 1 |
| Kizaki, H; Lui, MS; Weber, G | 1 |
| Chan, PJ; McGovren, JP; Neil, GL; Stewart, JC | 1 |
| Roberts, J; Rosenfeld, H | 1 |
| Kufe, DW; Loh, E | 1 |
| Biles, C; Martin, DG; Mizsak, SA | 1 |
| Allen, LM; Clubb, KJ; Meck, RA; Yunis, AA | 1 |
| Cooney, DA; Kensler, TW; Reck, LJ | 1 |
| Böttcher, T; Orth, R; Sieber, SA | 1 |
2 review(s) available for oxazoles and acivicin
| Article | Year |
|---|---|
Acivicin in 1985.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Humans; Isoxazoles; Kinetics; Male; Nervous System; Oxazoles | 1985 |
Acivicin. An antitumor antibiotic.
Topics: Animals; Antibiotics, Antineoplastic; Glycine; Humans; Isoxazoles; Neoplasms; Neoplasms, Experimental; Oxazoles | 1981 |
5 trial(s) available for oxazoles and acivicin
| Article | Year |
|---|---|
Phase II trial of continuous drug infusions in advanced ovarian carcinoma: acivicin versus vinblastine.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Infusions, Intravenous; Isoxazoles; Middle Aged; Ovarian Neoplasms; Oxazoles | 1989 |
Phase II evaluation of acivicin in lung cancer: a Southeastern Cancer Study Group Trial.
Topics: Antibiotics, Antineoplastic; Carcinoma, Bronchogenic; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Oxazoles | 1986 |
Phase II clinical trial of acivicin in advanced breast cancer: an Eastern Cooperative Oncology Group Study.
Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles | 1986 |
Phase II trial of acivicin in advanced breast carcinoma: a Cancer and Leukemia Group B Study.
Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Brain Diseases; Breast Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles | 1986 |
Pharmacokinetic and biochemical studies on acivicin in phase I clinical trials.
Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Clinical Trials as Topic; Drug Evaluation; Female; Humans; Isoxazoles; Kinetics; Liver Diseases; Male; Oxazoles | 1985 |
77 other study(ies) available for oxazoles and acivicin
| Article | Year |
|---|---|
The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of gamma-glutamyl transpeptidase inhibition.
Topics: Animals; Catheterization; gamma-Glutamyltransferase; Glutathione; Hydroquinones; Isoxazoles; Kidney; Male; Oxazoles; Rats; Rats, Inbred Strains | 1990 |
Prolonged survival by tumor-bearing rats treated with acivicin and total parenteral nutrition.
Topics: Animals; Antimetabolites, Antineoplastic; Combined Modality Therapy; Isoxazoles; Male; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Survival Rate | 1990 |
Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia.
Topics: Animals; Azaserine; Azo Compounds; Carbon-Nitrogen Ligases; Cell Line; Chromatography, High Pressure Liquid; Diazooxonorleucine; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Isoxazoles; Leukemia L1210; Ligases; Mice; Nucleotides; Oxazoles; Spectrophotometry, Ultraviolet | 1990 |
Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis.
Topics: Animals; Antiprotozoal Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cells, Cultured; Enzyme Activation; Isoxazoles; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Oxazoles | 1990 |
Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture.
Topics: Amino Acids; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cats; Central Nervous System; Electrolytes; Female; Glucose; Humans; Infusions, Intravenous; Isoxazoles; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Mice, Nude; Oxazoles; Parenteral Nutrition Solutions; Reference Values; Solutions; Transplantation, Heterologous | 1990 |
Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.
Topics: Animals; Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Oxazoles; Phosphoribosyl Pyrophosphate; Phosphotransferases | 1985 |
Enzyme targets of antiglutamine agents in cancer chemotherapy.
Topics: Animals; Anthranilate Synthase; Antibiotics, Antineoplastic; Azaserine; Drug Synergism; Glutamine; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nitrogenous Group Transferases; Oxazoles; Phosphoribosyl Pyrophosphate; Rats; Ribonucleotides; Transferases | 1985 |
Recovery of the activities of IMP dehydrogenase and GMP synthase after treatment with tiazofurin and acivicin in hepatoma cells in vitro.
Topics: Animals; Carbon-Nitrogen Ligases; Cycloheximide; Drug Interactions; IMP Dehydrogenase; Isoxazoles; Ketone Oxidoreductases; Ligases; Liver Neoplasms, Experimental; Oxazoles; Ribavirin; Ribonucleosides; Time Factors; Tumor Cells, Cultured | 1989 |
Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Drug Resistance; Genetic Variation; Glutamine; Isoxazoles; Kinetics; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Oxazoles; Phosphoribosyl Pyrophosphate | 1985 |
Animal behavioral and neurochemical effects of the CNS toxic amino acid antitumor agent, acivicin.
Topics: Action Potentials; Amino Acids; Animals; Antibiotics, Antineoplastic; Avoidance Learning; Behavior, Animal; Brain Chemistry; Cats; Discrimination, Psychological; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Macaca mulatta; Male; Mice; Neurons; Oxazoles; Rats; Rats, Inbred F344 | 1989 |
Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells.
Topics: Antimetabolites; Cell Line; Cisplatin; Drug Combinations; Growth Inhibitors; Humans; Isoxazoles; Lung Neoplasms; Oxazoles; Thymidine Kinase; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured | 1989 |
Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin.
Topics: Antibiotics, Antineoplastic; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Isoxazoles; Kinetics; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Leukocytes; Oxazoles; Reference Values; Tumor Cells, Cultured | 1989 |
Use of acivicin in the determination of rate constants for turnover of rat renal gamma-glutamyltranspeptidase.
Topics: Animals; gamma-Glutamyltransferase; Goats; Immunoglobulin G; Isoxazoles; Kidney; Kinetics; Mathematics; Oxazoles; Rats; Rats, Inbred Strains | 1985 |
Effect of inhibition of gamma-glutamyltranspeptidase by AT-125 (acivicin) on glutathione and cysteine levels in rat brain and plasma.
Topics: Animals; Antibiotics, Antineoplastic; Brain; Cysteine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains | 1985 |
Effect of acivicin on glutamine transport by rat renal brush border membrane vesicles.
Topics: Amino Acids; Animals; Biological Transport; gamma-Glutamyltransferase; Glucose; Glutamine; In Vitro Techniques; Isoxazoles; Kidney Cortex; Microvilli; Oxazoles; Rats | 1986 |
Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism.
Topics: Animals; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Kidney Tubules; Male; Methionine Sulfoximine; Oxazoles; Rats | 1987 |
Embryotoxicity elicited by inhibition of gamma-glutamyltransferase by Acivicin and transferase antibodies in cultured rat embryos.
Topics: Animals; Embryo, Mammalian; gamma-Glutamyltransferase; Immunoglobulin G; Isoxazoles; Organ Culture Techniques; Oxazoles; Proteins; Rats; Rats, Inbred Strains | 1987 |
Effects of AT-125 on the nephrotoxicity of hexachloro-1,3-butadiene in rats.
Topics: Animals; Butadienes; gamma-Glutamyltransferase; Glycosuria; Isoxazoles; Kidney Diseases; Kidney Function Tests; Male; Oxazoles; Rats; Rats, Inbred Strains; Urine | 1988 |
Acivicin inhibits Crithidia fasciculata growth in a serum-free medium and inactivates carbamoyl-phosphate synthetase II in vivo.
Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Count; Cells, Cultured; Crithidia; Culture Media; Cytidine; Guanosine; Isoxazoles; Oxazoles | 1988 |
Quantitative determination of acivicin in bulk drug and pharmaceutical formulations by ion-pair high-performance liquid chromatography.
Topics: Antineoplastic Agents; Benzyl Alcohol; Benzyl Alcohols; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Isoxazoles; Oxazoles; Perchlorates; Powders; Solutions | 1986 |
Phase II study of acivicin in non-small cell lung cancer: a National Cancer Institute of Canada Study.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Carcinoma, Non-Small-Cell Lung; Cognition Disorders; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Male; Middle Aged; Oxazoles | 1986 |
Acivicin reduces tumor growth during total parenteral nutrition (TPN).
Topics: Animals; Antimetabolites; Body Weight; Glutamine; Isoxazoles; Male; Neoplasm Transplantation; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Soft Tissue Neoplasms | 1987 |
Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition.
Topics: Animals; Antimetabolites; Body Weight; Eating; Energy Intake; Insulin; Isoxazoles; Male; Muscle Proteins; Muscles; Organ Size; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1988 |
Phase I-II trial of acivicin in adult acute leukemia.
Topics: Aged; Antibiotics, Antineoplastic; Drug Evaluation; Humans; Isoxazoles; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Middle Aged; Oxazoles | 1988 |
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
Topics: Adult; Aged; Alanine; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Administration Schedule; Drug Evaluation; Female; Humans; Isoxazoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Oxazoles; Thiadiazoles; Vinblastine | 1988 |
The effects of acivicin on glutamine transport by renal basolateral membrane vesicles.
Topics: Alanine; Animals; Biological Transport; Cell Membrane; Glutamine; Isoxazoles; Kidney; Oxazoles; Rats | 1988 |
Reduction of tumor growth following treatment with a glutamine antimetabolite.
Topics: Amino Acids; Animals; Antibiotics, Antineoplastic; Antimetabolites; Body Weight; Energy Intake; Glutamine; Isoxazoles; Male; Methylcholanthrene; Oxazoles; Rats; Rats, Inbred F344; Sarcoma, Experimental | 1988 |
Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin.
Topics: Animals; Aspartate Carbamoyltransferase; Bone Marrow; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Deoxycytidine Kinase; Isoxazoles; Ligases; Orotidine-5'-Phosphate Decarboxylase; Oxazoles; Rats; Ribavirin; Ribonucleoside Diphosphate Reductase; Ribonucleosides; Thymidine Monophosphate; Thymidylate Synthase | 1988 |
Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and acivicin in sensitive and resistant tumor cell lines.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Azo Compounds; Biological Transport; Colonic Neoplasms; Diazooxonorleucine; Drug Resistance; Glutamine; Humans; Isoxazoles; Kinetics; Leukemia P388; Lung Neoplasms; Mice; Neoplasms, Experimental; Oxazoles; Tumor Cells, Cultured | 1988 |
Phase II study of acivicin as a 72-hr continuous infusion in patients with untreated colorectal cancer. A National Cancer Institute of Canada Clinical Trials Group Study.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Colonic Neoplasms; Drug Evaluation; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Oxazoles; Rectal Neoplasms | 1987 |
Phase II trial of acivicin in malignant mesothelioma.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Isoxazoles; Male; Mesothelioma; Middle Aged; Oxazoles; Peritoneal Neoplasms; Pleural Neoplasms | 1987 |
Inactivation of Crithidia fasciculata carbamoyl phosphate synthetase II by the antitumor drug acivicin.
Topics: Ammonia; Animals; Antineoplastic Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Crithidia; Enzyme Activation; Enzyme Inhibitors; Isoxazoles; Ligases; Oxazoles; Stimulation, Chemical | 1987 |
Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines.
Topics: Antimetabolites; Azo Compounds; Cell Cycle; Cell Line; Colonic Neoplasms; Diazooxonorleucine; Drug Evaluation, Preclinical; Glutaminase; Glutamine; Humans; Isoxazoles; Lung Neoplasms; Neoplasms, Experimental; Oxazoles | 1987 |
Phase II trial of acivicin in patients with advanced epithelial ovarian carcinoma. A Gynecologic Oncology Group Study.
Topics: Adult; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Nervous System Diseases; Ovarian Neoplasms; Oxazoles | 1986 |
Acivicin (AT 125, U 42126): isolation and structure of an alkali-induced contaminant.
Topics: Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Drug Contamination; Hydrogen-Ion Concentration; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles | 1986 |
Phase II trial of acivicin in patients with advanced colorectal carcinoma.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Leukopenia; Male; Middle Aged; Nausea; Neoplasm Metastasis; Oxazoles; Rectal Neoplasms; Vomiting | 1986 |
Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells.
Topics: Animals; Bicarbonates; Carbon Radioisotopes; Cytidine Triphosphate; Guanosine Triphosphate; Isoxazoles; Kinetics; Leukemia L1210; Mice; Naphthoquinones; Oxazoles; Pyrimidines; Uracil Nucleotides | 1986 |
Inactivation by acivicin of rat brain CTP and GMP synthetases and depression of CTP and GTP concentrations.
Topics: Animals; Antibiotics, Antineoplastic; Brain; Carbon-Nitrogen Ligases; Cell Line; Cytidine Triphosphate; Guanosine Triphosphate; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Oxazoles; Rats; Rats, Inbred ACI | 1985 |
The glutamine analog acivicin as antipyrimidine. Studies on the interrelationship between pyrimidine and urea synthesis in liver.
Topics: Animals; Antibiotics, Antineoplastic; Carbamyl Phosphate; Cytosol; Female; Isoxazoles; Liver; Mitochondria, Liver; Orotic Acid; Oxazoles; Pyrimidines; Rats; Rats, Inbred Strains; Urea | 1985 |
Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma.
Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Colon; Colonic Neoplasms; Glutamine; Humans; Isoxazoles; Kinetics; Ligases; Oxazoles | 1985 |
Effect of L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid on urinary excretion of methylmercury in the mouse.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Feces; Glutathione; Isoxazoles; Methylmercury Compounds; Mice; Mice, Inbred CBA; Oxazoles | 1985 |
Quantitation of antitumor agent acivicin in plasma by gas chromatography/mass spectrometry.
Topics: Antibiotics, Antineoplastic; Gas Chromatography-Mass Spectrometry; Humans; Isoxazoles; Oxazoles | 1985 |
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
Topics: Antibiotics, Antineoplastic; Cells, Cultured; gamma-Glutamyltransferase; Glycine; Half-Life; Humans; Isoxazoles; Oxazoles; Pancreatic Neoplasms; Time Factors | 1980 |
The inhibition of gamma-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(alpha S, 5S)-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
Topics: Animals; Cells, Cultured; gamma-Glutamyltransferase; Glutathione; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Rats | 1980 |
The effect of the glutamine analog, AT-125, on the cell cycle of MCF-7 and BT-20 human breast carcinoma cells using DNA flow cytometry.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line; Cytological Techniques; DNA, Neoplasm; gamma-Glutamyltransferase; Glycine; Humans; Isoxazoles; Oxazoles | 1980 |
Interaction of AT-125, (alpha S,5S)-amino-3-chloro-4,5-dihydroisoxazoleacetic acid, with bovine kidney gamma-glutamyl transpeptidase.
Topics: Anilides; Animals; Cattle; gamma-Glutamyltransferase; Glutamates; Glutamine; Glycine; In Vitro Techniques; Isoxazoles; Kidney; Kinetics; Oxazoles | 1981 |
Affinity labeling of gamma-glutamyl transpeptidase by glutamine antagonists. Effects of the gamma-glutamyl transferase and proteinase activities.
Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; gamma-Glutamyltransferase; Glycine; Isoxazoles; Kidney; Macromolecular Substances; Oxazoles; Rats; Structure-Activity Relationship | 1980 |
Interaction of the antitumor drug, L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) with renal brush border membranes. Specific labeling of gamma-glutamyl transpeptidase.
Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; gamma-Glutamyltransferase; Glycine; Isoxazoles; Kidney; Male; Microvilli; Molecular Weight; Oxazoles; Rats | 1980 |
Differential effect of AT-125 on rat renal glutaminase activities.
Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Phosphates; Rats | 1981 |
Effect of AT-125 on in situ renal gamma-glutamyltransferase activity.
Topics: Animals; Antimetabolites; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Isoxazoles; Kidney; Male; Oxazoles; Rats | 1982 |
The binding mechanism of glutathione and the anti-tumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125;NSC-163501) to gamma-glutamyltransferase.
Topics: Animals; Antineoplastic Agents; Arginine; Binding Sites; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Oxazoles; Phenylglyoxal; Protein Binding; Rats | 1983 |
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Dactinomycin; Deoxyribonucleotides; Glutamine; Humans; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Rats; Rats, Inbred Strains; Ribonucleotides; Sarcoma, Experimental | 1982 |
Synergistic interaction between acivicin (AT-125) and 6-thioguanine in the murine leukemia L1210. Biochemical and cytokinetic considerations.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Guanine Nucleotides; Isoxazoles; Leukemia L1210; Mice; Oxazoles; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thioguanine | 1984 |
Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin.
Topics: Animals; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Drug; IMP Dehydrogenase; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nucleotides; Oxazoles; Pentosephosphates; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Rats; Ribavirin; Ribonucleosides | 1984 |
Plasmin-activated prodrugs for cancer chemotherapy. 1. Synthesis and biological activity of peptidylacivicin and peptidylphenylenediamine mustard.
Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Female; Fibrinolysin; Isoxazoles; Melanoma; Mice; Nitrogen Mustard Compounds; Oligopeptides; Ovarian Neoplasms; Oxazoles; Plasminogen Activators | 1983 |
Acivicin: a new glutamine antagonist in clinical trials.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Drug Evaluation; Female; Glutamine; Half-Life; Humans; Isoxazoles; Kinetics; Leukemia, Experimental; Liver Neoplasms, Experimental; Macaca mulatta; Male; Mice; Neoplasms; Oxazoles; Purines; Pyrimidines; Sarcoma, Experimental | 1984 |
Phase II study of acivicin in colorectal carcinoma: a National Cancer Institute of Canada study.
Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System Diseases; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Hematologic Diseases; Humans; Infusions, Parenteral; Isoxazoles; Male; Middle Aged; Oxazoles; Rectal Neoplasms | 1984 |
Phase I evaluation of AT-125 single dose every three weeks.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System; Drug Administration Schedule; Drug Evaluation; Glutamine; Humans; Isoxazoles; Middle Aged; Neoplasms; Oxazoles | 1984 |
Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole.
Topics: Antibiotics, Antineoplastic; Cell Cycle; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Humans; Isoxazoles; Kinetics; Oxazoles; Ribonucleosides; Ribonucleotides | 1984 |
Collateral sensitivity to N-(phosphonacetyl)-L-aspartic acid in a line of P388 leukemia cells selected for resistance to L-(alpha S, 5S)-alpha-amino-3- chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
Topics: Adenine Phosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Ammonia); Drug Resistance; Hypoxanthine Phosphoribosyltransferase; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred Strains; Organophosphorus Compounds; Oxazoles; Phosphonoacetic Acid; Purines; Pyrimidines | 1983 |
Effects of acivicin and dipyridamole on hepatoma 3924A cells.
Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Deoxycytidine; Dipyridamole; Isoxazoles; Kinetics; Liver Neoplasms, Experimental; Oxazoles; Rats; Ribonucleosides | 1983 |
Combined action of acivicin and D-galactosamine on pyrimidine nucleotide metabolism in hepatoma cells.
Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Interactions; Female; Galactosamine; In Vitro Techniques; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Pyrimidine Nucleotides; Rats; Rats, Inbred Strains | 1983 |
Phase II trial of acivicin in advanced metastatic breast cancer.
Topics: Adult; Breast Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles | 1983 |
Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
Topics: Anthranilate Synthase; Binding, Competitive; Glutamate Synthase; Glutamine; Glycine; Isoxazoles; Kinetics; Nitrogenous Group Transferases; Oxazoles; Serratia marcescens; Transferases | 1980 |
Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma.
Topics: Amidophosphoribosyltransferase; Animals; Antimetabolites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Nucleotides; Oxazoles; Pentosyltransferases; Phenotype; Rats; Rats, Inbred ACI | 1982 |
In vivo inactivation by acivicin of carbamoyl-phosphate synthetase II in rat hepatoma.
Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); In Vitro Techniques; Isoxazoles; Kinetics; Ligases; Liver; Liver Neoplasms, Experimental; Magnesium; Male; Oxazoles; Rats; Rats, Inbred ACI | 1982 |
Plasma and cerebrospinal fluid pharmacokinetics of acivicin in Ommaya reservoir-bearing rhesus monkeys.
Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Half-Life; Isoxazoles; Kinetics; Macaca mulatta; Male; Methods; Models, Biological; Oxazoles | 1982 |
Phase I and pharmacological study of acivicin by 24-hour continuous infusion.
Topics: Antimetabolites; Digestive System; Drug Evaluation; Humans; Infusions, Parenteral; Isoxazoles; Kinetics; Neoplasms; Nervous System; Oxazoles | 1982 |
Effects of acivicin and PALA, singly and in combination, on de novo pyrimidine biosynthesis.
Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line; Isoxazoles; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nucleic Acids; Organophosphorus Compounds; Orotic Acid; Oxazoles; Phosphonoacetic Acid; Pyrimidines | 1982 |
Biochemical pharmacology of acivicin in rat hepatoma cells.
Topics: Animals; Carbon-Nitrogen Ligases; Cell Line; Cell Survival; Cytidine; Deoxycytidine; Deoxyribonucleotides; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Guanosine; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Oxazoles; Rats; Ribonucleotides | 1982 |
Sex- and age-related mouse toxicity and disposition of the amino acid antitumor agent, acivicin.
Topics: Age Factors; Animals; Antineoplastic Agents; Female; Glycine; Half-Life; Isoxazoles; Kinetics; Male; Metabolic Clearance Rate; Mice; Oxazoles; Sex Factors; Testosterone; Tissue Distribution | 1981 |
Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
Topics: Amidohydrolases; Animals; Asparagine; Azo Compounds; Cell Line; Diazooxonorleucine; DNA; Glutamine; Glycine; Isoxazoles; Kinetics; Leukemia L1210; Mice; Oxazoles; Temperature | 1981 |
Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid.
Topics: Animals; Aspartic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxycytosine Nucleotides; Deoxyribonucleosides; Drug Synergism; Glycine; Isoxazoles; Leukemia L1210; Mice; Organophosphorus Compounds; Orotic Acid; Oxazoles; Phosphonoacetic Acid; Pyrimidines; Ribonucleosides | 1981 |
Derivatization and purification of acivicin (AT-125, U-42,126).
Topics: Antibiotics, Antineoplastic; Antimetabolites; Glycine; Isoxazoles; Oxazoles | 1981 |
Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, Acivicin (NSC 163501).
Topics: Cell Count; Cell Division; Cell Line; Cell Survival; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Humans; Interphase; Isoxazoles; Kinetics; Male; Oxazoles; Pancreatic Neoplasms; Time Factors | 1981 |
Therapeutic effects of acivicin and N-(phosphonacetyl)-L-aspartic acid in a biochemically designed trial against a N-(phosphonacetyl)-L-aspartic acid-resistant variant of the Lewis lung carcinoma.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carcinoma; Drug Therapy, Combination; Glycine; Isoxazoles; Ligases; Lung Neoplasms; Neoplasms, Experimental; Organophosphorus Compounds; Oxazoles; Phosphonoacetic Acid; Pyrimidines; Rats | 1981 |
The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds.
Topics: Aldehyde Dehydrogenase; Bacterial Proteins; Isomerism; Isoxazoles; Oxazoles; Staphylococcus aureus | 2010 |