Page last updated: 2024-08-21

oxazoles and acivicin

oxazoles has been researched along with acivicin in 84 studies

Research

Studies (84)

TimeframeStudies, this research(%)All Research%
pre-199078 (92.86)18.7374
1990's5 (5.95)18.2507
2000's0 (0.00)29.6817
2010's1 (1.19)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lau, SS; Monks, TJ1
Cao, LQ; Chance, WT; Fischer, JE1
Christopherson, RI; Lyons, SD; Sant, ME1
Bhaduri, A; Mukherjee, T; Roy, K1
Bailey, H; Earhart, RH; McGovren, JP; Williams, MG1
Ardalan, B; Chandrasekaran, B; Hrishikeshavan, HJ1
Prajda, N1
Ikegami, T; Natsumeda, Y; Weber, G1
Ardalan, B; Deas, M; Jayaram, HN; Johnson, RK1
Einspahr, FJ; McGovren, JP; Piercey, MF; Schreur, PJ; Tang, AH; VonVoigtlander, PF; Williams, MG1
Futami, H; Irino, S; Shiotani, T; Yamaji, Y; Yamauchi, N1
Chitneni, SR; Moore, JO; Nichols, KE; Weinberg, JB1
Davis, TE; Earhart, RH; Faraggi, D; Khandekar, JD; Schinella, RA1
Capraro, MA; Hughey, RP1
Burk, RF; Hill, KE; Von Hoff, DD1
Sastrasinh, M; Sastrasinh, S2
Curthoys, NP; Scott, RD1
Harris, C; Juchau, MR; Stark, KL1
Davis, ME1
Aoki, T; Oya, H2
Ryan, TM; Zoutendam, PH1
Eisenhauer, E; Maksymiuk, A; Maroun, JA; Pater, J; Stewart, DJ; Young, V1
Cao, L; Chance, WT; Fischer, JE; Foley-Nelson, T; Nelson, JL1
Cao, L; Chance, WT; Fischer, JE1
Capizzi, RL; Craig, JB; Powell, BL; Richards, F1
Carbone, PP; Davis, TE; Earle, JD; Elson, PJ; Glover, DJ; Hahn, RG; Kvols, LK; Trump, DL; Vogl, SE1
Cao, L; Chance, WT; Fischer, JE; Kim, MW; Nelson, JL1
Emrani, J; Hashimoto, Y; Ikegami, T; Natsumeda, Y; Prajda, N; Reardon, MA; Szondy, S; Weber, G1
Huber, KR; Roberts, J; Rosenfeld, H1
Eisenhauer, EA; Fields, AL; Maroun, JA; Walde, PL1
Birch, R; Greco, A; Johnson, R; Kramer, BS; Prestridge, K1
Chang, YC; Falkson, G; Knuiman, MW; Pandya, KJ; Skeel, RT; Willson, JK; Wolter, JM1
Booth, BW; Budman, D; Ellison, RR; Khojasteh, A; Korzun, AH; Weiss, RB; Wood, W1
Borden, EC; Falkson, G; Simson, IW; Vorobiof, DA1
Huber, KR; Mayer, EP; Mitchell, DF; Roberts, J1
Blessing, JA; Buchsbaum, HJ; DiSaia, PJ; McGuire, WP1
Martin, DG; Mizsak, SA; Nielsen, JW1
Adolphson, CC; Ajani, JA; Barlogie, B; Bedikian, AY; Bodey, GP; Korinek, J; Stroehlein, JR1
Christopherson, RI; Kemp, AJ; Lyons, SD1
Achleitner, E; Lui, MS; Weber, G1
Gerok, W; Häussinger, D; Holstege, A; Pausch, J; Rasenack, J1
Ardalan, B; Belt, RJ; Benjamin, RS; McGovren, JP; Ohnuma, T; Pratt, EA; Taylor, SA1
Earhart, RH; Neil, GL1
Aoki, T; Eble, JN; Glover, JL; Sebolt, JS; Weber, G1
Kostyniak, PJ; Mulder, KM1
McGovren, JP; Roach, BL; Robins, RH; Williams, MG1
Allen, L; Meck, R; Yunis, A1
Ellis, WW; Meck, RA; Reed, DJ1
Allen, LM; Thornthwaite, JT1
Allen, LM; Corrigan, MV; Meinking, T1
Gardell, SJ; Tate, SS1
Kozak, EM; Tate, SS1
Curthoys, NP; Shapiro, RA1
Dass, PD; Welbourne, TC1
Curthoys, NP; Reed, DJ; Schasteen, CS1
Aoki, T; Burt, ME; Denton, JE; Faderan, MA; Lui, MS; Prajda, N; Reardon, MA; Sebolt, J; Weber, G; Zhen, YS1
Bhalla, K; Deitch, A; Grant, S; Nayak, R1
Elliott, WL; Faderan, MA; Liepnieks, JJ; Lui, MS; Natsumeda, Y; Weber, G1
Carl, PL; Chakravarty, PK; Katzenellenbogen, JA; Weber, MJ1
Alonso, MT; Leyland-Jones, B; O'Dwyer, PJ1
Cripps, C; Eisenhauer, E; Fields, AL; Maroun, JA; Pater, JL; Stewart, DJ1
Belt, RJ; Haas, CD; Hoogstraten, B; Joseph, U; Taylor, S1
Bittner, G; Fischer, PH; Pamukcu, R; Willson, JK1
Ardalan, B; Jayaram, HN; Johnson, RK1
Lui, MS; Weber, G; Zhen, YS1
Keppler, DO; Leube, K1
Bodey, G; Fleishman, G; Murphy, WK; Yap, HY1
Bower, SG; Tso, JY; Zalkin, H1
Bruno, S; McGovren, JP; Neil, GL; Penta, J; Poster, DS1
Aoki, T; Denton, JE; Lui, MS; Sebolt, J; Weber, G1
Aoki, T; Sebolt, J; Weber, G1
Elfring, GL; McGovren, JP; Poplack, DG; Smith, RB; Soares, N; Stewart, JC; Von Hoff, DD; Wood, JH1
Kufe, DW; McGovren, JP; Schade, D; Weiss, GR1
Cooney, DA; Jayaram, HN; Kensler, TW1
Kizaki, H; Lui, MS; Weber, G1
Chan, PJ; McGovren, JP; Neil, GL; Stewart, JC1
Roberts, J; Rosenfeld, H1
Kufe, DW; Loh, E1
Biles, C; Martin, DG; Mizsak, SA1
Allen, LM; Clubb, KJ; Meck, RA; Yunis, AA1
Cooney, DA; Kensler, TW; Reck, LJ1
Böttcher, T; Orth, R; Sieber, SA1

Reviews

2 review(s) available for oxazoles and acivicin

ArticleYear
Acivicin in 1985.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Drug Evaluation; Female; Humans; Isoxazoles; Kinetics; Male; Nervous System; Oxazoles

1985
Acivicin. An antitumor antibiotic.
    Cancer clinical trials, 1981,Fall, Volume: 4, Issue:3

    Topics: Animals; Antibiotics, Antineoplastic; Glycine; Humans; Isoxazoles; Neoplasms; Neoplasms, Experimental; Oxazoles

1981

Trials

5 trial(s) available for oxazoles and acivicin

ArticleYear
Phase II trial of continuous drug infusions in advanced ovarian carcinoma: acivicin versus vinblastine.
    Investigational new drugs, 1989, Volume: 7, Issue:2-3

    Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Infusions, Intravenous; Isoxazoles; Middle Aged; Ovarian Neoplasms; Oxazoles

1989
Phase II evaluation of acivicin in lung cancer: a Southeastern Cancer Study Group Trial.
    Cancer treatment reports, 1986, Volume: 70, Issue:8

    Topics: Antibiotics, Antineoplastic; Carcinoma, Bronchogenic; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Oxazoles

1986
Phase II clinical trial of acivicin in advanced breast cancer: an Eastern Cooperative Oncology Group Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:10

    Topics: Antibiotics, Antineoplastic; Breast Neoplasms; Central Nervous System Diseases; Clinical Trials as Topic; Drug Evaluation; Female; Gastrointestinal Diseases; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1986
Phase II trial of acivicin in advanced breast carcinoma: a Cancer and Leukemia Group B Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:10

    Topics: Adenocarcinoma; Aged; Antibiotics, Antineoplastic; Brain Diseases; Breast Neoplasms; Clinical Trials as Topic; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1986
Pharmacokinetic and biochemical studies on acivicin in phase I clinical trials.
    Cancer research, 1985, Volume: 45, Issue:9

    Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Clinical Trials as Topic; Drug Evaluation; Female; Humans; Isoxazoles; Kinetics; Liver Diseases; Male; Oxazoles

1985

Other Studies

77 other study(ies) available for oxazoles and acivicin

ArticleYear
The in vivo disposition of 2-bromo-[14C]hydroquinone and the effect of gamma-glutamyl transpeptidase inhibition.
    Toxicology and applied pharmacology, 1990, Mar-15, Volume: 103, Issue:1

    Topics: Animals; Catheterization; gamma-Glutamyltransferase; Glutathione; Hydroquinones; Isoxazoles; Kidney; Male; Oxazoles; Rats; Rats, Inbred Strains

1990
Prolonged survival by tumor-bearing rats treated with acivicin and total parenteral nutrition.
    Journal of the National Cancer Institute, 1990, Mar-07, Volume: 82, Issue:5

    Topics: Animals; Antimetabolites, Antineoplastic; Combined Modality Therapy; Isoxazoles; Male; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Survival Rate

1990
Cytotoxic mechanisms of glutamine antagonists in mouse L1210 leukemia.
    The Journal of biological chemistry, 1990, Jul-05, Volume: 265, Issue:19

    Topics: Animals; Azaserine; Azo Compounds; Carbon-Nitrogen Ligases; Cell Line; Chromatography, High Pressure Liquid; Diazooxonorleucine; Glutamine; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Isoxazoles; Leukemia L1210; Ligases; Mice; Nucleotides; Oxazoles; Spectrophotometry, Ultraviolet

1990
Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis.
    Biochemical and biophysical research communications, 1990, Jul-31, Volume: 170, Issue:2

    Topics: Animals; Antiprotozoal Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cells, Cultured; Enzyme Activation; Isoxazoles; Leishmaniasis, Visceral; Mice; Mice, Inbred BALB C; Oxazoles

1990
Prevention of central nervous system toxicity of the antitumor antibiotic acivicin by concomitant infusion of an amino acid mixture.
    Cancer research, 1990, Sep-01, Volume: 50, Issue:17

    Topics: Amino Acids; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cats; Central Nervous System; Electrolytes; Female; Glucose; Humans; Infusions, Intravenous; Isoxazoles; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Mice, Nude; Oxazoles; Parenteral Nutrition Solutions; Reference Values; Solutions; Transplantation, Heterologous

1990
Biochemical mechanisms for the scheduled synergism of (alpha S, 5S)-2 amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid and 5-fluorouracil in P388 leukemia.
    Cancer chemotherapy and pharmacology, 1985, Volume: 15, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Fluorouracil; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Oxazoles; Phosphoribosyl Pyrophosphate; Phosphotransferases

1985
Enzyme targets of antiglutamine agents in cancer chemotherapy.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Anthranilate Synthase; Antibiotics, Antineoplastic; Azaserine; Drug Synergism; Glutamine; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nitrogenous Group Transferases; Oxazoles; Phosphoribosyl Pyrophosphate; Rats; Ribonucleotides; Transferases

1985
Recovery of the activities of IMP dehydrogenase and GMP synthase after treatment with tiazofurin and acivicin in hepatoma cells in vitro.
    Advances in experimental medicine and biology, 1989, Volume: 253B

    Topics: Animals; Carbon-Nitrogen Ligases; Cycloheximide; Drug Interactions; IMP Dehydrogenase; Isoxazoles; Ketone Oxidoreductases; Ligases; Liver Neoplasms, Experimental; Oxazoles; Ribavirin; Ribonucleosides; Time Factors; Tumor Cells, Cultured

1989
Mechanism of resistance of a variant of P388 leukemia to L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
    Cancer research, 1985, Volume: 45, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Biological Transport; Drug Resistance; Genetic Variation; Glutamine; Isoxazoles; Kinetics; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Oxazoles; Phosphoribosyl Pyrophosphate

1985
Animal behavioral and neurochemical effects of the CNS toxic amino acid antitumor agent, acivicin.
    Research communications in chemical pathology and pharmacology, 1989, Volume: 63, Issue:2

    Topics: Action Potentials; Amino Acids; Animals; Antibiotics, Antineoplastic; Avoidance Learning; Behavior, Animal; Brain Chemistry; Cats; Discrimination, Psychological; Female; gamma-Aminobutyric Acid; Iontophoresis; Isoxazoles; Macaca mulatta; Male; Mice; Neurons; Oxazoles; Rats; Rats, Inbred F344

1989
Effects of the combination of acivicin and cis-diamminedichloroplatinum(II) on thymidylate synthesis of A549 lung cancer cells.
    Biochemical and biophysical research communications, 1989, May-30, Volume: 161, Issue:1

    Topics: Antimetabolites; Cell Line; Cisplatin; Drug Combinations; Growth Inhibitors; Humans; Isoxazoles; Lung Neoplasms; Oxazoles; Thymidine Kinase; Thymidine Monophosphate; Thymidylate Synthase; Thymine Nucleotides; Tumor Cells, Cultured

1989
Monocytoid differentiation of freshly isolated human myeloid leukemia cells and HL-60 cells induced by the glutamine antagonist acivicin.
    Blood, 1989, Volume: 74, Issue:5

    Topics: Antibiotics, Antineoplastic; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Dose-Response Relationship, Drug; Humans; Isoxazoles; Kinetics; Leukemia, Myeloid; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Leukocytes; Oxazoles; Reference Values; Tumor Cells, Cultured

1989
Use of acivicin in the determination of rate constants for turnover of rat renal gamma-glutamyltranspeptidase.
    The Journal of biological chemistry, 1985, Mar-25, Volume: 260, Issue:6

    Topics: Animals; gamma-Glutamyltransferase; Goats; Immunoglobulin G; Isoxazoles; Kidney; Kinetics; Mathematics; Oxazoles; Rats; Rats, Inbred Strains

1985
Effect of inhibition of gamma-glutamyltranspeptidase by AT-125 (acivicin) on glutathione and cysteine levels in rat brain and plasma.
    Investigational new drugs, 1985, Volume: 3, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Brain; Cysteine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Male; Oxazoles; Rats; Rats, Inbred Strains

1985
Effect of acivicin on glutamine transport by rat renal brush border membrane vesicles.
    The Journal of laboratory and clinical medicine, 1986, Volume: 108, Issue:4

    Topics: Amino Acids; Animals; Biological Transport; gamma-Glutamyltransferase; Glucose; Glutamine; In Vitro Techniques; Isoxazoles; Kidney Cortex; Microvilli; Oxazoles; Rats

1986
Renal clearance of glutathione measured in rats pretreated with inhibitors of glutathione metabolism.
    The American journal of physiology, 1987, Volume: 252, Issue:5 Pt 2

    Topics: Animals; Buthionine Sulfoximine; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Kidney Tubules; Male; Methionine Sulfoximine; Oxazoles; Rats

1987
Embryotoxicity elicited by inhibition of gamma-glutamyltransferase by Acivicin and transferase antibodies in cultured rat embryos.
    Toxicology and applied pharmacology, 1987, Jun-15, Volume: 89, Issue:1

    Topics: Animals; Embryo, Mammalian; gamma-Glutamyltransferase; Immunoglobulin G; Isoxazoles; Organ Culture Techniques; Oxazoles; Proteins; Rats; Rats, Inbred Strains

1987
Effects of AT-125 on the nephrotoxicity of hexachloro-1,3-butadiene in rats.
    Toxicology and applied pharmacology, 1988, Volume: 95, Issue:1

    Topics: Animals; Butadienes; gamma-Glutamyltransferase; Glycosuria; Isoxazoles; Kidney Diseases; Kidney Function Tests; Male; Oxazoles; Rats; Rats, Inbred Strains; Urine

1988
Acivicin inhibits Crithidia fasciculata growth in a serum-free medium and inactivates carbamoyl-phosphate synthetase II in vivo.
    Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology, 1988, Volume: 90, Issue:2

    Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Count; Cells, Cultured; Crithidia; Culture Media; Cytidine; Guanosine; Isoxazoles; Oxazoles

1988
Quantitative determination of acivicin in bulk drug and pharmaceutical formulations by ion-pair high-performance liquid chromatography.
    Journal of chromatography, 1986, Apr-23, Volume: 357, Issue:1

    Topics: Antineoplastic Agents; Benzyl Alcohol; Benzyl Alcohols; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Isoxazoles; Oxazoles; Perchlorates; Powders; Solutions

1986
Phase II study of acivicin in non-small cell lung cancer: a National Cancer Institute of Canada Study.
    Cancer treatment reports, 1986, Volume: 70, Issue:11

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Carcinoma, Non-Small-Cell Lung; Cognition Disorders; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Lung Neoplasms; Male; Middle Aged; Oxazoles

1986
Acivicin reduces tumor growth during total parenteral nutrition (TPN).
    Surgery, 1987, Volume: 102, Issue:2

    Topics: Animals; Antimetabolites; Body Weight; Glutamine; Isoxazoles; Male; Neoplasm Transplantation; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental; Soft Tissue Neoplasms

1987
Insulin and acivicin improve host nutrition and prevent tumor growth during total parenteral nutrition.
    Annals of surgery, 1988, Volume: 208, Issue:4

    Topics: Animals; Antimetabolites; Body Weight; Eating; Energy Intake; Insulin; Isoxazoles; Male; Muscle Proteins; Muscles; Organ Size; Oxazoles; Parenteral Nutrition, Total; Rats; Rats, Inbred F344; Sarcoma, Experimental

1988
Phase I-II trial of acivicin in adult acute leukemia.
    Investigational new drugs, 1988, Volume: 6, Issue:1

    Topics: Aged; Antibiotics, Antineoplastic; Drug Evaluation; Humans; Isoxazoles; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Middle Aged; Oxazoles

1988
Phase II trials of 5-day vinblastine infusion (NSC 49842), L-alanosine (NSC 153353), acivicin (NSC 163501), and aminothiadiazole (NSC 4728) in patients with recurrent or metastatic renal cell carcinoma.
    Investigational new drugs, 1988, Volume: 6, Issue:2

    Topics: Adult; Aged; Alanine; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Administration Schedule; Drug Evaluation; Female; Humans; Isoxazoles; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Oxazoles; Thiadiazoles; Vinblastine

1988
The effects of acivicin on glutamine transport by renal basolateral membrane vesicles.
    Contributions to nephrology, 1988, Volume: 63

    Topics: Alanine; Animals; Biological Transport; Cell Membrane; Glutamine; Isoxazoles; Kidney; Oxazoles; Rats

1988
Reduction of tumor growth following treatment with a glutamine antimetabolite.
    Life sciences, 1988, Volume: 42, Issue:1

    Topics: Amino Acids; Animals; Antibiotics, Antineoplastic; Antimetabolites; Body Weight; Energy Intake; Glutamine; Isoxazoles; Male; Methylcholanthrene; Oxazoles; Rats; Rats, Inbred F344; Sarcoma, Experimental

1988
Enzymic programs of rat bone marrow and the impact of acivicin and tiazofurin.
    Biochemical pharmacology, 1988, Mar-01, Volume: 37, Issue:5

    Topics: Animals; Aspartate Carbamoyltransferase; Bone Marrow; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Deoxycytidine Kinase; Isoxazoles; Ligases; Orotidine-5'-Phosphate Decarboxylase; Oxazoles; Rats; Ribavirin; Ribonucleoside Diphosphate Reductase; Ribonucleosides; Thymidine Monophosphate; Thymidylate Synthase

1988
Uptake of glutamine antimetabolites 6-diazo-5-oxo-L-norleucine (DON) and acivicin in sensitive and resistant tumor cell lines.
    International journal of cancer, 1988, May-15, Volume: 41, Issue:5

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Azo Compounds; Biological Transport; Colonic Neoplasms; Diazooxonorleucine; Drug Resistance; Glutamine; Humans; Isoxazoles; Kinetics; Leukemia P388; Lung Neoplasms; Mice; Neoplasms, Experimental; Oxazoles; Tumor Cells, Cultured

1988
Phase II study of acivicin as a 72-hr continuous infusion in patients with untreated colorectal cancer. A National Cancer Institute of Canada Clinical Trials Group Study.
    Investigational new drugs, 1987, Volume: 5, Issue:4

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Canada; Colonic Neoplasms; Drug Evaluation; Female; Humans; Infusions, Intravenous; Isoxazoles; Male; Middle Aged; Oxazoles; Rectal Neoplasms

1987
Phase II trial of acivicin in malignant mesothelioma.
    Cancer treatment reports, 1987, Volume: 71, Issue:5

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Drug Evaluation; Female; Humans; Isoxazoles; Male; Mesothelioma; Middle Aged; Oxazoles; Peritoneal Neoplasms; Pleural Neoplasms

1987
Inactivation of Crithidia fasciculata carbamoyl phosphate synthetase II by the antitumor drug acivicin.
    Molecular and biochemical parasitology, 1987, Volume: 23, Issue:2

    Topics: Ammonia; Animals; Antineoplastic Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Crithidia; Enzyme Activation; Enzyme Inhibitors; Isoxazoles; Ligases; Oxazoles; Stimulation, Chemical

1987
Cell cycle phase perturbations by 6-diazo-5-oxo-L-norleucine and acivicin in normal and neoplastic human cell lines.
    British journal of cancer, 1987, Volume: 55, Issue:6

    Topics: Antimetabolites; Azo Compounds; Cell Cycle; Cell Line; Colonic Neoplasms; Diazooxonorleucine; Drug Evaluation, Preclinical; Glutaminase; Glutamine; Humans; Isoxazoles; Lung Neoplasms; Neoplasms, Experimental; Oxazoles

1987
Phase II trial of acivicin in patients with advanced epithelial ovarian carcinoma. A Gynecologic Oncology Group Study.
    Investigational new drugs, 1986, Volume: 4, Issue:1

    Topics: Adult; Antibiotics, Antineoplastic; Carcinoma, Squamous Cell; Dose-Response Relationship, Drug; Drug Evaluation; Female; Hematologic Diseases; Humans; Isoxazoles; Middle Aged; Nervous System Diseases; Ovarian Neoplasms; Oxazoles

1986
Acivicin (AT 125, U 42126): isolation and structure of an alkali-induced contaminant.
    The Journal of antibiotics, 1986, Volume: 39, Issue:4

    Topics: Antibiotics, Antineoplastic; Chemical Phenomena; Chemistry; Drug Contamination; Hydrogen-Ion Concentration; Isoxazoles; Magnetic Resonance Spectroscopy; Oxazoles

1986
Phase II trial of acivicin in patients with advanced colorectal carcinoma.
    American journal of clinical oncology, 1986, Volume: 9, Issue:3

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Colonic Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Leukopenia; Male; Middle Aged; Nausea; Neoplasm Metastasis; Oxazoles; Rectal Neoplasms; Vomiting

1986
Effects of acivicin and dichloroallyl lawsone upon pyrimidine biosynthesis in mouse L1210 leukemia cells.
    The Journal of biological chemistry, 1986, Nov-15, Volume: 261, Issue:32

    Topics: Animals; Bicarbonates; Carbon Radioisotopes; Cytidine Triphosphate; Guanosine Triphosphate; Isoxazoles; Kinetics; Leukemia L1210; Mice; Naphthoquinones; Oxazoles; Pyrimidines; Uracil Nucleotides

1986
Inactivation by acivicin of rat brain CTP and GMP synthetases and depression of CTP and GTP concentrations.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Antibiotics, Antineoplastic; Brain; Carbon-Nitrogen Ligases; Cell Line; Cytidine Triphosphate; Guanosine Triphosphate; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Oxazoles; Rats; Rats, Inbred ACI

1985
The glutamine analog acivicin as antipyrimidine. Studies on the interrelationship between pyrimidine and urea synthesis in liver.
    Advances in enzyme regulation, 1985, Volume: 24

    Topics: Animals; Antibiotics, Antineoplastic; Carbamyl Phosphate; Cytosol; Female; Isoxazoles; Liver; Mitochondria, Liver; Orotic Acid; Oxazoles; Pyrimidines; Rats; Rats, Inbred Strains; Urea

1985
Inactivation by acivicin of carbamoyl-phosphate synthetase II of human colon carcinoma.
    Biochemical pharmacology, 1985, Jan-01, Volume: 34, Issue:1

    Topics: Antibiotics, Antineoplastic; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Colon; Colonic Neoplasms; Glutamine; Humans; Isoxazoles; Kinetics; Ligases; Oxazoles

1985
Effect of L-(alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid on urinary excretion of methylmercury in the mouse.
    The Journal of pharmacology and experimental therapeutics, 1985, Volume: 234, Issue:1

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Feces; Glutathione; Isoxazoles; Methylmercury Compounds; Mice; Mice, Inbred CBA; Oxazoles

1985
Quantitation of antitumor agent acivicin in plasma by gas chromatography/mass spectrometry.
    Analytical chemistry, 1985, Volume: 57, Issue:11

    Topics: Antibiotics, Antineoplastic; Gas Chromatography-Mass Spectrometry; Humans; Isoxazoles; Oxazoles

1985
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
    Research communications in chemical pathology and pharmacology, 1980, Volume: 27, Issue:1

    Topics: Antibiotics, Antineoplastic; Cells, Cultured; gamma-Glutamyltransferase; Glycine; Half-Life; Humans; Isoxazoles; Oxazoles; Pancreatic Neoplasms; Time Factors

1980
The inhibition of gamma-glutamyl transpeptidase and glutathione metabolism of isolated rat kidney cells by L-(alpha S, 5S)-alpha-amino-3-chloro-4, 5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501).
    Biochemical and biophysical research communications, 1980, Jun-30, Volume: 94, Issue:4

    Topics: Animals; Cells, Cultured; gamma-Glutamyltransferase; Glutathione; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Rats

1980
The effect of the glutamine analog, AT-125, on the cell cycle of MCF-7 and BT-20 human breast carcinoma cells using DNA flow cytometry.
    Research communications in chemical pathology and pharmacology, 1980, Volume: 29, Issue:2

    Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Line; Cytological Techniques; DNA, Neoplasm; gamma-Glutamyltransferase; Glycine; Humans; Isoxazoles; Oxazoles

1980
Interaction of AT-125, (alpha S,5S)-amino-3-chloro-4,5-dihydroisoxazoleacetic acid, with bovine kidney gamma-glutamyl transpeptidase.
    Chemico-biological interactions, 1981, Volume: 33, Issue:2-3

    Topics: Anilides; Animals; Cattle; gamma-Glutamyltransferase; Glutamates; Glutamine; Glycine; In Vitro Techniques; Isoxazoles; Kidney; Kinetics; Oxazoles

1981
Affinity labeling of gamma-glutamyl transpeptidase by glutamine antagonists. Effects of the gamma-glutamyl transferase and proteinase activities.
    FEBS letters, 1980, Dec-29, Volume: 122, Issue:2

    Topics: Affinity Labels; Animals; Chemical Phenomena; Chemistry; gamma-Glutamyltransferase; Glycine; Isoxazoles; Kidney; Macromolecular Substances; Oxazoles; Rats; Structure-Activity Relationship

1980
Interaction of the antitumor drug, L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125) with renal brush border membranes. Specific labeling of gamma-glutamyl transpeptidase.
    FEBS letters, 1980, Dec-29, Volume: 122, Issue:2

    Topics: Animals; Antineoplastic Agents; Chemical Phenomena; Chemistry; gamma-Glutamyltransferase; Glycine; Isoxazoles; Kidney; Male; Microvilli; Molecular Weight; Oxazoles; Rats

1980
Differential effect of AT-125 on rat renal glutaminase activities.
    FEBS letters, 1981, Oct-12, Volume: 133, Issue:1

    Topics: Ammonia; Animals; gamma-Glutamyltransferase; Glutaminase; Glutamine; Glycine; Isoxazoles; Kidney; Kinetics; Male; Oxazoles; Phosphates; Rats

1981
Effect of AT-125 on in situ renal gamma-glutamyltransferase activity.
    FEBS letters, 1982, Jul-19, Volume: 144, Issue:1

    Topics: Animals; Antimetabolites; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Isoxazoles; Kidney; Male; Oxazoles; Rats

1982
The binding mechanism of glutathione and the anti-tumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125;NSC-163501) to gamma-glutamyltransferase.
    Biochemical and biophysical research communications, 1983, Apr-29, Volume: 112, Issue:2

    Topics: Animals; Antineoplastic Agents; Arginine; Binding Sites; gamma-Glutamyltransferase; Glutathione; Isoxazoles; Kidney; Oxazoles; Phenylglyoxal; Protein Binding; Rats

1983
Multi-enzyme-targeted chemotherapy by acivicin and actinomycin.
    Advances in enzyme regulation, 1982, Volume: 20

    Topics: Animals; Antimetabolites, Antineoplastic; Cells, Cultured; Dactinomycin; Deoxyribonucleotides; Glutamine; Humans; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Rats; Rats, Inbred Strains; Ribonucleotides; Sarcoma, Experimental

1982
Synergistic interaction between acivicin (AT-125) and 6-thioguanine in the murine leukemia L1210. Biochemical and cytokinetic considerations.
    Biochemical pharmacology, 1984, Jan-15, Volume: 33, Issue:2

    Topics: Animals; Antimetabolites, Antineoplastic; Cell Cycle; Cell Survival; DNA, Neoplasm; Drug Synergism; Flow Cytometry; Guanine Nucleotides; Isoxazoles; Leukemia L1210; Mice; Oxazoles; Phosphoribosyl Pyrophosphate; RNA, Neoplasm; Thioguanine

1984
Control of enzymic programs and nucleotide pattern in cancer cells by acivicin and tiazofurin.
    Advances in enzyme regulation, 1984, Volume: 22

    Topics: Animals; Antineoplastic Agents; Cell Line; Dose-Response Relationship, Drug; IMP Dehydrogenase; Isoxazoles; Liver; Liver Neoplasms, Experimental; Nucleotides; Oxazoles; Pentosephosphates; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Rats; Ribavirin; Ribonucleosides

1984
Plasmin-activated prodrugs for cancer chemotherapy. 1. Synthesis and biological activity of peptidylacivicin and peptidylphenylenediamine mustard.
    Journal of medicinal chemistry, 1983, Volume: 26, Issue:5

    Topics: Animals; Antineoplastic Agents; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Female; Fibrinolysin; Isoxazoles; Melanoma; Mice; Nitrogen Mustard Compounds; Oligopeptides; Ovarian Neoplasms; Oxazoles; Plasminogen Activators

1983
Acivicin: a new glutamine antagonist in clinical trials.
    Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1984, Volume: 2, Issue:9

    Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites; Dose-Response Relationship, Drug; Drug Evaluation; Female; Glutamine; Half-Life; Humans; Isoxazoles; Kinetics; Leukemia, Experimental; Liver Neoplasms, Experimental; Macaca mulatta; Male; Mice; Neoplasms; Oxazoles; Purines; Pyrimidines; Sarcoma, Experimental

1984
Phase II study of acivicin in colorectal carcinoma: a National Cancer Institute of Canada study.
    Cancer treatment reports, 1984, Volume: 68, Issue:9

    Topics: Adenocarcinoma; Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System Diseases; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Hematologic Diseases; Humans; Infusions, Parenteral; Isoxazoles; Male; Middle Aged; Oxazoles; Rectal Neoplasms

1984
Phase I evaluation of AT-125 single dose every three weeks.
    Investigational new drugs, 1984, Volume: 2, Issue:3

    Topics: Adult; Aged; Antibiotics, Antineoplastic; Central Nervous System; Drug Administration Schedule; Drug Evaluation; Glutamine; Humans; Isoxazoles; Middle Aged; Neoplasms; Oxazoles

1984
Enhancement of the sensitivity of human colon cancer cells to growth inhibition by acivicin achieved through inhibition of nucleic acid precursor salvage by dipyridamole.
    Cancer research, 1984, Volume: 44, Issue:8

    Topics: Antibiotics, Antineoplastic; Cell Cycle; Cell Line; Cell Survival; Colonic Neoplasms; Dipyridamole; Humans; Isoxazoles; Kinetics; Oxazoles; Ribonucleosides; Ribonucleotides

1984
Collateral sensitivity to N-(phosphonacetyl)-L-aspartic acid in a line of P388 leukemia cells selected for resistance to L-(alpha S, 5S)-alpha-amino-3- chloro-4,5-dihydro-5-isoxazoleacetic acid (acivicin).
    Cancer research, 1983, Volume: 43, Issue:4

    Topics: Adenine Phosphoribosyltransferase; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Ammonia); Drug Resistance; Hypoxanthine Phosphoribosyltransferase; Isoxazoles; Leukemia P388; Leukemia, Experimental; Mice; Mice, Inbred Strains; Organophosphorus Compounds; Oxazoles; Phosphonoacetic Acid; Purines; Pyrimidines

1983
Effects of acivicin and dipyridamole on hepatoma 3924A cells.
    Cancer research, 1983, Volume: 43, Issue:4

    Topics: Animals; Antimetabolites, Antineoplastic; Biological Transport; Deoxycytidine; Dipyridamole; Isoxazoles; Kinetics; Liver Neoplasms, Experimental; Oxazoles; Rats; Ribonucleosides

1983
Combined action of acivicin and D-galactosamine on pyrimidine nucleotide metabolism in hepatoma cells.
    Biochemical pharmacology, 1983, Jun-15, Volume: 32, Issue:12

    Topics: Animals; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Drug Interactions; Female; Galactosamine; In Vitro Techniques; Isoxazoles; Liver Neoplasms, Experimental; Oxazoles; Pyrimidine Nucleotides; Rats; Rats, Inbred Strains

1983
Phase II trial of acivicin in advanced metastatic breast cancer.
    Cancer treatment reports, 1983, Volume: 67, Issue:9

    Topics: Adult; Breast Neoplasms; Drug Evaluation; Female; Humans; Isoxazoles; Middle Aged; Neoplasm Metastasis; Oxazoles

1983
Mechanism of inactivation of glutamine amidotransferases by the antitumor drug L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125).
    The Journal of biological chemistry, 1980, Jul-25, Volume: 255, Issue:14

    Topics: Anthranilate Synthase; Binding, Competitive; Glutamate Synthase; Glutamine; Glycine; Isoxazoles; Kinetics; Nitrogenous Group Transferases; Oxazoles; Serratia marcescens; Transferases

1980
Rapid in vivo inactivation by acivicin of CTP synthetase, carbamoyl-phosphate synthetase II, and amidophosphoribosyltransferase in hepatoma.
    Life sciences, 1982, Mar-29, Volume: 30, Issue:13

    Topics: Amidophosphoribosyltransferase; Animals; Antimetabolites; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbon-Nitrogen Ligases; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Male; Nucleotides; Oxazoles; Pentosyltransferases; Phenotype; Rats; Rats, Inbred ACI

1982
In vivo inactivation by acivicin of carbamoyl-phosphate synthetase II in rat hepatoma.
    Biochemical pharmacology, 1982, Mar-15, Volume: 31, Issue:6

    Topics: Adenosine Triphosphate; Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); In Vitro Techniques; Isoxazoles; Kinetics; Ligases; Liver; Liver Neoplasms, Experimental; Magnesium; Male; Oxazoles; Rats; Rats, Inbred ACI

1982
Plasma and cerebrospinal fluid pharmacokinetics of acivicin in Ommaya reservoir-bearing rhesus monkeys.
    Cancer treatment reports, 1982, Volume: 66, Issue:6

    Topics: Animals; Antibiotics, Antineoplastic; Blood-Brain Barrier; Half-Life; Isoxazoles; Kinetics; Macaca mulatta; Male; Methods; Models, Biological; Oxazoles

1982
Phase I and pharmacological study of acivicin by 24-hour continuous infusion.
    Cancer research, 1982, Volume: 42, Issue:9

    Topics: Antimetabolites; Digestive System; Drug Evaluation; Humans; Infusions, Parenteral; Isoxazoles; Kinetics; Neoplasms; Nervous System; Oxazoles

1982
Effects of acivicin and PALA, singly and in combination, on de novo pyrimidine biosynthesis.
    Advances in enzyme regulation, 1982, Volume: 20

    Topics: Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Cell Line; Isoxazoles; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Nucleic Acids; Organophosphorus Compounds; Orotic Acid; Oxazoles; Phosphonoacetic Acid; Pyrimidines

1982
Biochemical pharmacology of acivicin in rat hepatoma cells.
    Biochemical pharmacology, 1982, Nov-01, Volume: 31, Issue:21

    Topics: Animals; Carbon-Nitrogen Ligases; Cell Line; Cell Survival; Cytidine; Deoxycytidine; Deoxyribonucleotides; Dose-Response Relationship, Drug; Drug Synergism; Glycine; Guanosine; Isoxazoles; Ligases; Liver; Liver Neoplasms, Experimental; Oxazoles; Rats; Ribonucleotides

1982
Sex- and age-related mouse toxicity and disposition of the amino acid antitumor agent, acivicin.
    The Journal of pharmacology and experimental therapeutics, 1981, Volume: 216, Issue:3

    Topics: Age Factors; Animals; Antineoplastic Agents; Female; Glycine; Half-Life; Isoxazoles; Kinetics; Male; Metabolic Clearance Rate; Mice; Oxazoles; Sex Factors; Testosterone; Tissue Distribution

1981
Enhancement of antitumor activity of glutamine antagonists 6-diazo-5-oxo-L-norleucine and acivicin in cell culture by glutaminase-asparaginase.
    Cancer research, 1981, Volume: 41, Issue:4

    Topics: Amidohydrolases; Animals; Asparagine; Azo Compounds; Cell Line; Diazooxonorleucine; DNA; Glutamine; Glycine; Isoxazoles; Kinetics; Leukemia L1210; Mice; Oxazoles; Temperature

1981
Synergistic effects with inhibitors of de novo pyrimidine synthesis, acivicin, and N-(phosphonacetyl)-L-aspartic acid.
    Cancer research, 1981, Volume: 41, Issue:9 Pt 1

    Topics: Animals; Aspartic Acid; Cells, Cultured; Chromatography, High Pressure Liquid; Deoxycytosine Nucleotides; Deoxyribonucleosides; Drug Synergism; Glycine; Isoxazoles; Leukemia L1210; Mice; Organophosphorus Compounds; Orotic Acid; Oxazoles; Phosphonoacetic Acid; Pyrimidines; Ribonucleosides

1981
Derivatization and purification of acivicin (AT-125, U-42,126).
    The Journal of antibiotics, 1981, Volume: 34, Issue:4

    Topics: Antibiotics, Antineoplastic; Antimetabolites; Glycine; Isoxazoles; Oxazoles

1981
Inhibition of cell cycle progression of human pancreatic carcinoma cells in vitro by L-(alpha S, 5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid, Acivicin (NSC 163501).
    Cancer research, 1981, Volume: 41, Issue:11 Pt 1

    Topics: Cell Count; Cell Division; Cell Line; Cell Survival; Colony-Forming Units Assay; DNA; Dose-Response Relationship, Drug; Humans; Interphase; Isoxazoles; Kinetics; Male; Oxazoles; Pancreatic Neoplasms; Time Factors

1981
Therapeutic effects of acivicin and N-(phosphonacetyl)-L-aspartic acid in a biochemically designed trial against a N-(phosphonacetyl)-L-aspartic acid-resistant variant of the Lewis lung carcinoma.
    Cancer research, 1981, Volume: 41, Issue:3

    Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carcinoma; Drug Therapy, Combination; Glycine; Isoxazoles; Ligases; Lung Neoplasms; Neoplasms, Experimental; Organophosphorus Compounds; Oxazoles; Phosphonoacetic Acid; Pyrimidines; Rats

1981
The biological targets of acivicin inspired 3-chloro- and 3-bromodihydroisoxazole scaffolds.
    Chemical communications (Cambridge, England), 2010, Nov-28, Volume: 46, Issue:44

    Topics: Aldehyde Dehydrogenase; Bacterial Proteins; Isomerism; Isoxazoles; Oxazoles; Staphylococcus aureus

2010