ovalbumin and traxanox

ovalbumin has been researched along with traxanox* in 1 studies

Other Studies

1 other study(ies) available for ovalbumin and traxanox

Article	Year
Anti-allergic activities of a new benzopyranopyridine derivative Y-12,141 in rats. International archives of allergy and applied immunology, 1979, Volume: 59, Issue:1 Passive cutaneous anaphylaxis (PCA) mediated in rats by IgE-like antibodies against egg albumin or the benzylpenicilloyl determinant was inhibited in a dose-dependent manner by intravenous treatment with Y-12,141; the ED50 was 0.09--0.2 mg/kg. The inhibitory effect of Y-12,141 ON PCA was about 5 times as potent as that of disodium cromoglycate (DSCG). Oral treatment with Y-12,141 resulted in the inhibition of PCA, showing an ED50 of 2.5 mg/kg. This action of Y-12,141 on PCA was considered to be due to the inhibition of the release of allergic mediatros from mast cells in a manner similar to DSCG. The results suggest that Y-12,141 may have an anti-allergic activity. Topics: Animals; Azoles; Chromones; Cromolyn Sodium; Dose-Response Relationship, Immunologic; Female; Histamine Antagonists; Histamine Release; Hypersensitivity; Immunoglobulin E; Male; Mice; Mice, Inbred ICR; Ovalbumin; Passive Cutaneous Anaphylaxis; Penicillin G; Rats; Tetrazoles	1979

Article

Year

Anti-allergic activities of a new benzopyranopyridine derivative Y-12,141 in rats.

International archives of allergy and applied immunology, 1979, Volume: 59, Issue:1

Passive cutaneous anaphylaxis (PCA) mediated in rats by IgE-like antibodies against egg albumin or the benzylpenicilloyl determinant was inhibited in a dose-dependent manner by intravenous treatment with Y-12,141; the ED50 was 0.09--0.2 mg/kg. The inhibitory effect of Y-12,141 ON PCA was about 5 times as potent as that of disodium cromoglycate (DSCG). Oral treatment with Y-12,141 resulted in the inhibition of PCA, showing an ED50 of 2.5 mg/kg. This action of Y-12,141 on PCA was considered to be due to the inhibition of the release of allergic mediatros from mast cells in a manner similar to DSCG. The results suggest that Y-12,141 may have an anti-allergic activity.

Topics: Animals; Azoles; Chromones; Cromolyn Sodium; Dose-Response Relationship, Immunologic; Female; Histamine Antagonists; Histamine Release; Hypersensitivity; Immunoglobulin E; Male; Mice; Mice, Inbred ICR; Ovalbumin; Passive Cutaneous Anaphylaxis; Penicillin G; Rats; Tetrazoles

1979