ovalbumin and ovatodiolide

ovalbumin has been researched along with ovatodiolide* in 1 studies

Other Studies

1 other study(ies) available for ovalbumin and ovatodiolide

Article	Year
Ovatodiolide inhibits the maturation of allergen-induced bone marrow-derived dendritic cells and induction of Th2 cell differentiation. International immunopharmacology, 2013, Volume: 17, Issue:3 Ovatodiolide was a unique macrocyclic diterpenoid isolated from the traditional Chinese medicinal herb Anisomeles indica. The present study attempted to examine the ovatodiolide effects on dendritic cell (DC) maturation and immuno-stimulatory activities. The effects of ovatodiolide on DC surface molecule expression, cytokine production, and capacity to induce T-cell differentiation were examined in ovalbumin (OVA)/thymic stromal lymphopoietin (TSLP)-stimulated DCs. Ovatodiolide attenuated the expression of DC surface molecules CD80, CD86, histocompatibility complex (MHC) class II, and Th2 subset of CD4(+) T cells co-stimulatory molecule-OX40 ligand production. Additionally, ovatodiolide suppressed the CD4(+) T cells proliferation, and production of inflammatory cytokines interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-α. This study may be useful to develop ovatodiolide as a therapeutic adjuvant. Topics: Allergens; Animals; Antigens, Surface; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cytokines; Dendritic Cells; Diterpenes; Membrane Glycoproteins; Mice; Mice, Transgenic; Ovalbumin; OX40 Ligand; Th2 Cells; Thymic Stromal Lymphopoietin; Tumor Necrosis Factors	2013

Article

Year

Ovatodiolide inhibits the maturation of allergen-induced bone marrow-derived dendritic cells and induction of Th2 cell differentiation.

International immunopharmacology, 2013, Volume: 17, Issue:3

Ovatodiolide was a unique macrocyclic diterpenoid isolated from the traditional Chinese medicinal herb Anisomeles indica. The present study attempted to examine the ovatodiolide effects on dendritic cell (DC) maturation and immuno-stimulatory activities. The effects of ovatodiolide on DC surface molecule expression, cytokine production, and capacity to induce T-cell differentiation were examined in ovalbumin (OVA)/thymic stromal lymphopoietin (TSLP)-stimulated DCs. Ovatodiolide attenuated the expression of DC surface molecules CD80, CD86, histocompatibility complex (MHC) class II, and Th2 subset of CD4(+) T cells co-stimulatory molecule-OX40 ligand production. Additionally, ovatodiolide suppressed the CD4(+) T cells proliferation, and production of inflammatory cytokines interleukin (IL)-4, IL-5, and tumor necrosis factor (TNF)-α. This study may be useful to develop ovatodiolide as a therapeutic adjuvant.

Topics: Allergens; Animals; Antigens, Surface; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cytokines; Dendritic Cells; Diterpenes; Membrane Glycoproteins; Mice; Mice, Transgenic; Ovalbumin; OX40 Ligand; Th2 Cells; Thymic Stromal Lymphopoietin; Tumor Necrosis Factors

2013