ovalbumin and interleukin-1beta-(163-171)

Glycomacropeptide (GMP) is a bioactive peptide derived from milk κ-casein with immune-modulatory and anti-inflammatory properties. Food allergy (FA) is an adverse immune reaction with a broad spectrum of manifestations. Allergen intake induces persistent intestinal inflammation and tissue damage. In this study, the anti-allergic activity of GMP was evaluated using a rat ovalbumin (OVA)-induced FA model with gastrointestinal manifestation. Rats were orally GMP treated from 3 days prior and during FA development. The severity of food anaphylaxis and diarrheal episodes, antibody production and histamine level were measured. Histopathological changes, inflammation and predominant cytokine profile at intestine were analyzed. Oral GMP intake decreased clinical signs and diarrhea severity induced by allergen, with a significant reduction in intestinal edema and expression level of

Topics: Allergens; Anaphylaxis; Animals; Anti-Allergic Agents; Caseins; Cytokines; Disease Models, Animal; Down-Regulation; Food Hypersensitivity; GATA3 Transcription Factor; Interleukin-13; Interleukin-1beta; Interleukin-5; Intestines; Male; Mast Cells; Ovalbumin; Peptide Fragments; Rats; Rats, Wistar