ovalbumin and gamma-cyclodextrin

It is urgently needed to develop novel adjuvants for improving the safety and efficacy of vaccines. Metal-organic frameworks (MOFs), with high surface area, play an important role in drug delivery. With perfect biocompatibility and green preparation process, the γ-cyclodextrin metal-organic framework (γ-CD-MOF) fabricated with cyclodextrin and potassium suitable for antigen delivery. In this study, we modified γ-CD-MOF with span-85 to fabricate the SP-γ-CD-MOF as animal vaccine adjuvants. The ovalbumin (OVA) as the model antigen was encapsulated into particles to investigate the immune response. SP-γ-CD-MOF displayed excellent biocompatibility

Topics: Adjuvants, Vaccine; Animals; Animals, Outbred Strains; Bone Marrow Cells; Cell Survival; Chemistry, Pharmaceutical; Cytokines; Female; gamma-Cyclodextrins; Hemolysis; Immunoglobulin G; Metal-Organic Frameworks; Mice; Ovalbumin; Random Allocation; RAW 264.7 Cells; Spleen