ovalbumin and cupric-sulfide

The immunotherapy played a vital role in the treatment of metastatic tumor. To further enhance the effect of the immunotherapy, the combination of photothermal effect can not only eradicate the tumor cells by hyperthermia, but also improved the antigen release in vivo to achieve enhanced immune responses. In this study, a core-shell structured nanocomplex was developed by loading of ovalbumin (OVA) and copper sulfide nanoparticles (CuS-NPs) into the poly(lactide-co-glycolide acid) nanoparticles (PLGA-NPs). The CuS-NPs exhibited favorable photothermal effect, which significantly kill the 4T1 tumor cells in vitro. The photothermal effect of the CuS-NPs accelerated the OVA release, which led to higher levels of IL-6, IL-12 and TNF-α, and activation of CD8

Topics: Animals; Cell Line, Tumor; Copper; Dose-Response Relationship, Drug; Female; Immunotherapy; Light; Metal Nanoparticles; Mice; Mice, Inbred BALB C; Neoplasms; Ovalbumin; Photothermal Therapy; Polylactic Acid-Polyglycolic Acid Copolymer; RAW 264.7 Cells; Xenograft Model Antitumor Assays