ovalbumin and 7-ethoxycoumarin

ovalbumin has been researched along with 7-ethoxycoumarin* in 1 studies

Other Studies

1 other study(ies) available for ovalbumin and 7-ethoxycoumarin

ArticleYear
[Biotransformation processes in fertile hen's eggs. 1. Metabolic transformation of 7-ethoxycoumarin].
    Die Pharmazie, 1995, Volume: 50, Issue:3

    An alternative method for the investigation of biotransformations employing fertile chicken eggs has been developed. In these studies, solutions of 7-ethoxycoumarin were injected into the white of eggs from a standardized breed after brooding time of at least 8 days. After further incubation, the allantois was analyzed for metabolites of 7-ethoxycoumarin. The dealkylated metabolite of 7-ethoxycoumarin, namely 7-hydroxycoumarin, could be assayed in the allantois liquid by means of a new HPLC method. Furthermore, conjugates of 7-hydroxycoumarin, namely the glucuronid and the sulfate, can be detected indirectly in the allantois after conjugate cleavage. The inducability of the cytochrome P-450-dependent O-dealkylation has been studied with phenobarbital and 3-methylcholanthrene. An increase in the conversion of 7-ethoxycoumarin to 7-hydroxycoumarin was observed after addition of 3-methylcholanthrene. The detected metabolites demonstrate the usefulness of the developed model for studying biotransformation processes.

    Topics: Animals; Biotransformation; Chick Embryo; Chromatography, High Pressure Liquid; Coumarins; Cytochrome P-450 Enzyme System; Enzyme Induction; Glucuronates; Methylcholanthrene; Ovalbumin; Phenobarbital; Sulfates

1995