ovalbumin and 4-nitro-3-cresol

Dysfunction of immune regulation plays a crucial role in the pathogenesis of many immune disorders in the body. The underlying mechanism is still not completely understood. Environmental pollution contributes to immune de-regulation. 3-methyl-4-nitrophenol (MNP) is one of the major environmental pollutants. This study aims to investigate the role of MNP in compromising immune regulatory functions in the intestine. A food allergy (FA) mouse model was established using ovalbumin (OVA) as the specific antigen. The activities of regulatory T cells in the mouse intestine were evaluated by flow cytometry and enzyme-linked immunosorbent assay. We found that MNP reduced the CD4

Topics: Animals; Environmental Pollutants; Forkhead Transcription Factors; Interleukin-6; Intestines; Mice; Nitrophenols; Ovalbumin; Receptors, Estrogen; T-Lymphocytes, Regulatory; Th17 Cells; Transforming Growth Factor beta