ovalbumin and 4-cymene

Ceylon cinnamon has been shown to possess anti-inflammatory properties in many diseases including allergic inflammation.. The aim of this study was to analyse in more detail the effects of cinnamon extract (CE) and its major compounds p-cymene and trans-cinnamaldehyde (CA) on allergen-specific immune responses in vitro and in vivo.. Addition of CE, p-cymene or CA, but not ethanol significantly inhibited DC maturation and subsequent allergen-specific T cell proliferation as well as Th1 and Th2 cytokine production. Sulphidoleukotriene release and CD63 expression by basophils were also significantly diminished after addition of CE. In vivo, treatment of OVA-sensitized mice with CE led to a significant shift from OVA-specific IgE towards IgG2a production and to a strong inhibition of OVA-specific proliferation. Moreover, airway inflammation as well as anaphylaxis after intranasal or systemic allergen challenge was significantly reduced in CE-treated mice. Furthermore, topical application of CE prevented calcipotriol-induced atopic dermatitis-like inflammation in these mice.. Taken together, our data indicate that the anti-inflammatory effect of cinnamon might be exploited for treatment of allergic inflammation, which needs to be further investigated.

Topics: Acrolein; Animals; Basophils; Betula; CD4-Positive T-Lymphocytes; Cell Proliferation; Cinnamomum zeylanicum; Coculture Techniques; Cymenes; Cytokines; Dendritic Cells; Dermatitis, Atopic; Disease Models, Animal; Humans; Hypersensitivity, Immediate; Mice; Mice, Inbred BALB C; Ovalbumin; Plant Extracts; Plethysmography, Whole Body; Poaceae; Pollen; Respiratory Hypersensitivity; Rhinitis, Allergic, Seasonal