ouabain has been researched along with rostafuroxin in 22 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (18.18) | 18.2507 |
| 2000's | 10 (45.45) | 29.6817 |
| 2010's | 7 (31.82) | 24.3611 |
| 2020's | 1 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Bianchi, G; Cerri, A; Fedrizzi, G; Ferrari, P; Gobbini, M; Melloni, P; Quadri, L; Sputore, S; Torri, M | 1 |
| Dan, Y; Goto, A; Nagoshi, H; Omata, M; Yamada, K | 1 |
| Bianchi, G; Conti, F; Corsico, N; Duzzi, L; Ferrandi, M; Ferrari, P; Florio, M; Melloni, P; Padoani, G; Torielli, L; Vesci, L | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Melloni, P; Minotti, E; Padoani, G; Torielli, L; Tripodi, G | 1 |
| Schoner, W | 1 |
| Barassi, P; Bianchi, G; Ferrandi, M; Ferrari, P; Minotti, E; Molinari, I | 1 |
| Bianchi, G; Staessen, JA | 1 |
| Acceto, R; Bacchieri, A; Bianchi, G; Brand, E; Burnier, M; Celis, H; Citterio, L; de Leeuw, PW; Ferrari, P; Filipovský, J; Fournier, A; Kawecka-Jaszcz, K; Kuznetsova, T; Manunta, P; Nikitin, Y; O'Brien, ET; Redón, J; Staessen, JA; Thijs, L; Valentini, G | 1 |
| Barassi, P; Bianchi, G; Ferrandi, M; Ferrari, P; Minotti, E; Molinari, I; Torielli, L; Tripodi, G | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Valentini, G | 1 |
| Ferrandi, M; Ferrari, P; Manunta, P; Messaggio, E | 1 |
| Iwamoto, T; Kita, S | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Manunta, P; Valentini, G | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Molinari, I | 1 |
| Ferrari, P | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Molinari, I; Padoani, G; Rastaldi, MP; Salardi, S; Torielli, L | 1 |
| Argiolas, G; Bianchi, G; Carpini, SD; Citterio, L; Cusi, D; Ferrandi, M; Ferrari, P; Glorioso, N; Lanzani, C; Macciardi, F; Manunta, P; Messaggio, E; Salvi, E; Staessen, JA; Tripodi, G; Valentini, G | 1 |
| Bacchieri, A; Barton, J; Bianchi, G; Citterio, L; de Leeuw, PW; Dłużniewski, M; Espositi, ED; Ferrari, P; Glorioso, N; Januszewicz, A; Kawecka-Jaszcz, K; Lanzani, C; Manunta, P; Milyagin, V; Nikitin, Y; Souček, M; Staessen, JA; Stolarz-Skrzypek, K; Thijs, L; Timio, M; Tykarski, A; Valentini, G | 1 |
| Rossoni, LV; Wenceslau, CF | 1 |
| Bianchi, G; Ferrandi, M; Ferrari, P; Manunta, P; Molinari, I; Rastaldi, MP | 1 |
| Benigni, F; Bettiga, A; Buono, R; Colciago, G; Ferrandi, M; Ikehata, M; Manunta, P; Messaggio, E; Molinari, I; Montorsi, F; Rastaldi, MP; Salonia, A; Villa, L | 1 |
| Hoai Nguyen, BC; Jeong, JH; Kim, DJ; Kim, HC; Lichtstein, D; Nabeshima, T; Nah, SY; Nguyen, BT; Sharma, N; Shin, EJ; Tran, NKC | 1 |
8 review(s) available for ouabain and rostafuroxin
| Article | Year |
|---|---|
Endogenous cardiotonic steroids.
Topics: Androstanols; Animals; Antihypertensive Agents; Bufanolides; Cardenolides; Cardiac Glycosides; Cardiotonic Agents; Enzyme Inhibitors; Heart; Humans; Hypertension; Molecular Structure; Ouabain; Sodium-Potassium-Exchanging ATPase | 2001 |
Adducin and hypertension.
Topics: Alleles; Androstanols; Animals; Blood Pressure; Calmodulin-Binding Proteins; Forecasting; Heterozygote; Humans; Hypertension, Renal; Kidney Tubules; Mutation; Natriuresis; Ouabain; Polymorphism, Genetic; Protein Subunits; Rats; Sodium-Potassium-Exchanging ATPase | 2005 |
Ouabain antagonists as antihypertensive agents.
Topics: Androstanols; Animals; Antihypertensive Agents; Humans; Hypertension; Ouabain; Rats; Rats, Inbred SHR; Sodium-Potassium-Exchanging ATPase | 2005 |
Rostafuroxin: an ouabain antagonist that corrects renal and vascular Na+-K+- ATPase alterations in ouabain and adducin-dependent hypertension.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Vessels; Calmodulin-Binding Proteins; Humans; Hypertension; Kidney; Ouabain; Sodium-Potassium-Exchanging ATPase; Treatment Outcome | 2006 |
A new antihypertensive agent that antagonizes the prohypertensive effect of endogenous ouabain and adducin.
Topics: Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Humans; Hypertension; Ouabain; Risk Factors; Sodium Chloride; Sodium-Potassium-Exchanging ATPase | 2006 |
Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase.
Topics: Androstanols; Aniline Compounds; Animals; Blood Pressure; Calcium; Cardiac Glycosides; Cardiovascular System; Cell Membrane; Humans; Hypertension; Kidney; Muscle, Smooth, Vascular; Ouabain; Phenyl Ethers; Protein Binding; Sodium; Sodium-Calcium Exchanger; Sodium-Potassium-Exchanging ATPase; Sodium, Dietary; Vasoconstriction | 2006 |
Ouabain-dependent signaling in caveolae as a novel therapeutic target for hypertension.
Topics: Androstanols; Animals; Antihypertensive Agents; Calmodulin-Binding Proteins; Caveolae; Humans; Hypertension; Ouabain; Rats; Signal Transduction | 2006 |
Rostafuroxin: an ouabain-inhibitor counteracting specific forms of hypertension.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Clinical Trials, Phase II as Topic; Disease Models, Animal; ErbB Receptors; Humans; Hypertension; Kidney; Mutation; Ouabain; Polymorphism, Genetic; Signal Transduction; Sodium; Sodium-Potassium-Exchanging ATPase; src-Family Kinases | 2010 |
3 trial(s) available for ouabain and rostafuroxin
| Article | Year |
|---|---|
OASIS-HT: design of a pharmacogenomic dose-finding study.
Topics: Administration, Oral; Adult; Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Hypertension; Male; Middle Aged; Molecular Conformation; Ouabain; Risk Factors; Time Factors; Treatment Outcome | 2005 |
Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 2: clinical studies.
Topics: Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Female; Genetic Loci; Humans; Hydrochlorothiazide; Hypertension; Intramolecular Transferases; Kidney; Losartan; Male; Middle Aged; Mutant Proteins; Ouabain; Placebos; Polymorphism, Single Nucleotide; Systole; Time Factors; Transfection | 2010 |
Main results of the ouabain and adducin for Specific Intervention on Sodium in Hypertension Trial (OASIS-HT): a randomized placebo-controlled phase-2 dose-finding study of rostafuroxin.
Topics: Adult; Aldosterone; Androstanols; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Cross-Over Studies; Double-Blind Method; Europe; Female; Humans; Hypertension; Male; Middle Aged; Mutation; Ouabain; Renin; Sodium; Sodium-Potassium-Exchanging ATPase; Time Factors; Treatment Outcome | 2011 |
11 other study(ies) available for ouabain and rostafuroxin
| Article | Year |
|---|---|
17 beta-(3-furyl)-5 beta-androstane-3 beta, 14 beta, 17 alpha-triol (PST 2238). A very potent antihypertensive agent with a novel mechanism of action.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Kinetics; Molecular Structure; Ouabain; Rats; Rats, Mutant Strains; Sodium-Potassium-Exchanging ATPase | 1997 |
Role of ouabain-like compound in the regulation of transmembrane sodium and potassium gradients in rats.
Topics: Androstanols; Animals; Autoimmunity; Cell Membrane; Immunization; Male; Ouabain; Potassium; Rats; Rats, Wistar; Saline Solution, Hypertonic; Sodium; Sodium-Potassium-Exchanging ATPase | 1997 |
PST2238: a new antihypertensive compound that antagonizes the long-term pressor effect of ouabain.
Topics: Androstanols; Animals; Antihypertensive Agents; Cardiotonic Agents; Cells, Cultured; Male; Ouabain; Rats; Rats, Sprague-Dawley; Rats, Wistar; Sodium-Potassium-Exchanging ATPase | 1998 |
PST 2238: A new antihypertensive compound that modulates Na,K-ATPase in genetic hypertension.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Cells, Cultured; Down-Regulation; Enzyme Inhibitors; Heart Rate; Hypertension; Kidney Medulla; Male; Mutation; Ouabain; Rats; Rats, Inbred SHR; Rats, Inbred Strains; RNA, Messenger; Sodium-Potassium-Exchanging ATPase; Transfection | 1999 |
Organ hypertrophic signaling within caveolae membrane subdomains triggered by ouabain and antagonized by PST 2238.
Topics: Amlodipine; Androstanols; Animals; Blood Pressure; Caveolae; Enzyme Activation; Enzyme Inhibitors; Heart Ventricles; Hypertrophy; Immunosorbent Techniques; Kidney; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Organ Size; Ouabain; Phosphorylation; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Potassium-Exchanging ATPase; src-Family Kinases; Tyrosine | 2004 |
Targeting Ouabain- and Adducin-dependent mechanisms of hypertension and cardiovascular remodeling as a novel pharmacological approach.
Topics: Androstanols; Animals; Antihypertensive Agents; Calmodulin-Binding Proteins; Cardiovascular System; Humans; Hypertension; Models, Cardiovascular; Ouabain; Sodium-Potassium-Exchanging ATPase | 2007 |
Adducin- and ouabain-related gene variants predict the antihypertensive activity of rostafuroxin, part 1: experimental studies.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Calmodulin-Binding Proteins; Cell Line; Cell-Free System; Enzyme Activation; Fluorescent Antibody Technique; Humans; Kidney; Male; Mutant Proteins; Ouabain; Protein Binding; Protein Transport; Rats; Rats, Sprague-Dawley; Signal Transduction; Sodium-Potassium-Exchanging ATPase; src Homology Domains; src-Family Kinases; Transfection | 2010 |
Rostafuroxin ameliorates endothelial dysfunction and oxidative stress in resistance arteries from deoxycorticosterone acetate-salt hypertensive rats: the role of Na+K+-ATPase/ cSRC pathway.
Topics: Androstanols; Animals; Antihypertensive Agents; Blood Pressure; Cyclooxygenase 2; Desoxycorticosterone Acetate; Endothelium, Vascular; Humans; Hypertension; Male; Mesenteric Arteries; NADPH Oxidases; Ouabain; Oxidative Stress; Rats; Rats, Wistar; Signal Transduction; Sodium Chloride, Dietary; Sodium-Potassium-Exchanging ATPase; src-Family Kinases; Vascular Resistance; Vasodilation | 2014 |
Rostafuroxin protects from podocyte injury and proteinuria induced by adducin genetic variants and ouabain.
Topics: Androstanols; Animals; Antihypertensive Agents; Calmodulin-Binding Proteins; Disease Models, Animal; Female; Genetic Variation; Hypertension; Kidney; Male; Mice; Mice, Knockout; Ouabain; Podocytes; Proteinuria; Rats; Rats, Sprague-Dawley; Sodium-Potassium-Exchanging ATPase | 2014 |
Ouabain Contributes to Kidney Damage in a Rat Model of Renal Ischemia-Reperfusion Injury.
Topics: Androstanols; Animals; Kidney; Kidney Diseases; Nephrectomy; Ouabain; Rats; Rats, Sprague-Dawley; Reperfusion Injury | 2016 |
Ouabain inhibitor rostafuroxin attenuates dextromethorphan-induced manic potential.
Topics: Androstanols; Animals; Bipolar Disorder; Dextromethorphan; Disease Models, Animal; Locomotion; Male; Mice; Ouabain; Signal Transduction | 2021 |