ouabain and methotrexate

ouabain has been researched along with methotrexate in 32 studies

Research

Studies (32)

Timeframe	Studies, this research(%)	All Research%
pre-1990	16 (50.00)	18.7374
1990's	5 (15.63)	18.2507
2000's	5 (15.63)	29.6817
2010's	6 (18.75)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Andrews, PR; Craik, DJ; Martin, JL	1
Hagenbuch, B; Meier, PJ; Noé, B; Stieger, B	1
Hashimoto, Y; Ibaramoto, K; Inui, KI; Masuda, S; Saito, H; Takeuchi, A	1
Cha, SH; Endou, H; Kanai, Y; Kojima, R; Kusuhara, H; Sekine, T; Sugiyama, Y; Tsuda, M; Utsunomiya-Tate, N	1
Cha, SH; Endou, H; Fukushima , JI; Goya, T; Kanai, Y; Kobayashi, Y; Sekine, T	1
Cattori, V; Hagenbuch, B; Landmann, L; Meier, PJ; Meijer, DK; Stieger, B; van Montfoort, JE; Winterhalter, KH	1
Folkers, G; Hagenbuch, B; Klenk, U; Meier, PJ; Pizzagalli, F; Stieger, B	1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J	1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J	1
Campillo, NE; Guerra, A; Páez, JA	1
Benet, LZ; Brouwer, KL; Chu, X; Dahlin, A; Evers, R; Fischer, V; Giacomini, KM; Hillgren, KM; Hoffmaster, KA; Huang, SM; Ishikawa, T; Keppler, D; Kim, RB; Lee, CA; Niemi, M; Polli, JW; Sugiyama, Y; Swaan, PW; Tweedie, DJ; Ware, JA; Wright, SH; Yee, SW; Zamek-Gliszczynski, MJ; Zhang, L	1
Ghosh, I; Manoharlal, R; Prakash, O; Prasad, R; Puri, N; Sharma, M	1
Annand, R; Gozalbes, R; Jacewicz, M; Pineda-Lucena, A; Tsaioun, K	1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Siminovitch, L; Spandidos, DA	1
Nakamura, N; Okada, S	1
Koch, MJ; Nahrwold, DL; Rose, RC	1
Siminovitch, L	1
Briggs, WT; Horne, DW; Wagner, C	1
Arlett, CF; Cole, J	1
Hart, IR; Kalebic, T; McMillan, TJ; Stark, GR	1
Giulotto, E; Knights, C; Stark, GR	1
Schaefer, H; Schalla, W; Zesch, A	1
Cravioto, J; Escobedo, M	1
Bertino, JR; Nahas, A; Nixon, PF	1
Bishop, CF; Melnykovych, G	1
Henderson, ES; Owens, ES; Rall, DP; Rubin, RC	1
Gewirtz, DA; Goldman, ID; Randolph, JK; White, JC	1
Chen, TS; Huang, KC; Wenczak, BA	1
Lewis, WH; Parfett, CL; Wright, JA	1
Miller, DS; Pritchard, JB	1

Reviews

4 review(s) available for ouabain and methotrexate

Article	Year
Membrane transporters in drug development. Nature reviews. Drug discovery, 2010, Volume: 9, Issue:3 Topics: Animals; Computer Simulation; Decision Trees; Drug Approval; Drug Discovery; Drug Evaluation, Preclinical; Drug Interactions; Humans; Membrane Transport Proteins; Mice; Mice, Knockout; Prescription Drugs	2010
On the nature of hereditable variation in cultured somatic cells. Cell, 1976, Volume: 7, Issue:1 Topics: Amanitins; Azaguanine; Bromodeoxyuridine; Cell Line; Cells, Cultured; Chromosomes; Colchicine; Cycloheximide; Diploidy; Drug Resistance; Genes; Genes, Lethal; Genes, Recessive; Genetic Variation; Hybrid Cells; Hydroxyurea; Immunoglobulins; Lectins; Methotrexate; Mutation; Ouabain; Phenotype; Polyploidy; Temperature	1976
Somatic cell genetics: a review of drug resistance, lectin resistance and gene transfer in mammalian cells in culture. Canadian journal of genetics and cytology. Journal canadien de genetique et de cytologie, 1980, Volume: 22, Issue:4 Topics: Amanitins; Animals; Cell Line; Chromosomes; Cloning, Molecular; Colchicine; DNA, Recombinant; Drug Resistance; Genes; Humans; Hybrid Cells; Hydroxyurea; Lectins; Methotrexate; Mutation; Ouabain; Purines; Pyrimidines; Transformation, Genetic	1980
Dual pathways for organic anion secretion in renal proximal tubule. The Journal of experimental zoology, 1997, Dec-01, Volume: 279, Issue:5 Topics: Animals; Biological Transport; Fishes; Fluoresceins; Ion Pumps; Kidney Tubules, Proximal; Methotrexate; Organic Chemicals; Ouabain	1997

Other Studies

28 other study(ies) available for ouabain and methotrexate

Article	Year
Functional group contributions to drug-receptor interactions. Journal of medicinal chemistry, 1984, Volume: 27, Issue:12 Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship	1984
Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proceedings of the National Academy of Sciences of the United States of America, 1997, Sep-16, Volume: 94, Issue:19 Topics: Amino Acid Sequence; Animals; Anion Transport Proteins; Biological Transport; Brain; Cardiac Glycosides; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Humans; Male; Molecular Sequence Data; Rats; Rats, Sprague-Dawley; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis	1997
Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Molecular pharmacology, 1999, Volume: 55, Issue:4 Topics: Amino Acid Sequence; Animals; Base Sequence; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Kidney; Male; Membrane Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Oocytes; Organic Anion Transporters; Rats; Rats, Wistar; RNA, Messenger; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Tissue Distribution; Transfection; Xenopus laevis	1999
Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. The Journal of biological chemistry, 1999, May-07, Volume: 274, Issue:19 Topics: Amino Acid Sequence; Animals; Brain; Carrier Proteins; Cloning, Molecular; DNA, Complementary; Estrone; Molecular Sequence Data; Ochratoxins; Organic Anion Transporters, Sodium-Independent; p-Aminohippuric Acid; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Homology, Amino Acid; Xenopus laevis	1999
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Molecular pharmacology, 2001, Volume: 59, Issue:5 Topics: Amino Acid Sequence; Animals; Carrier Proteins; Chromosome Mapping; Chromosomes, Human, Pair 11; Cloning, Molecular; Gene Library; Humans; Kidney Tubules, Proximal; Molecular Sequence Data; Oocytes; Organic Anion Transporters, Sodium-Independent; Sequence Homology, Amino Acid; Tissue Distribution; Transfection; Xenopus laevis	2001
Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Archiv : European journal of physiology, 2001, Volume: 443, Issue:2 Topics: Animals; Biological Transport; Female; Liver; Oocytes; Organic Anion Transporters, Sodium-Independent; Rats; Solute Carrier Organic Anion Transporter Family Member 1B3; Subcellular Fractions; Substrate Specificity; Tissue Distribution; Xenopus laevis	2001
Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Molecular endocrinology (Baltimore, Md.), 2002, Volume: 16, Issue:10 Topics: Amino Acid Sequence; Animals; Brain; CHO Cells; Chromosomes, Human, Pair 12; Cloning, Molecular; Cricetinae; Diiodothyronines; Estradiol; Estrone; Female; Humans; Leydig Cells; Male; Membrane Proteins; Molecular Sequence Data; Oocytes; Organ Specificity; Organic Anion Transporters; Sequence Homology, Amino Acid; Sulfobromophthalein; Testis; Thyroxine; Triiodothyronine; Xenopus	2002
Chemical genetics reveals a complex functional ground state of neural stem cells. Nature chemical biology, 2007, Volume: 3, Issue:5 Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells	2007
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology, 2009, Volume: 5, Issue:10 Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection	2009
Neural computational prediction of oral drug absorption based on CODES 2D descriptors. European journal of medicinal chemistry, 2010, Volume: 45, Issue:3 Topics: Administration, Oral; Humans; Models, Chemical; Neural Networks, Computer; Permeability; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical	2010
Analysis of physico-chemical properties of substrates of ABC and MFS multidrug transporters of pathogenic Candida albicans. European journal of medicinal chemistry, 2010, Volume: 45, Issue:11 Topics: Candida albicans; Membrane Transport Proteins; Saccharomyces cerevisiae; Structure-Activity Relationship; Substrate Specificity	2010
QSAR-based permeability model for drug-like compounds. Bioorganic & medicinal chemistry, 2011, Apr-15, Volume: 19, Issue:8 Topics: Caco-2 Cells; Cell Membrane Permeability; Drug Discovery; Humans; Pharmaceutical Preparations; Pharmacokinetics; Quantitative Structure-Activity Relationship	2011
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions. Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10 Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Transfer of codominant markers by isolated metaphase chromosomes in Chinese hamster ovary cells. Proceedings of the National Academy of Sciences of the United States of America, 1977, Volume: 74, Issue:8 Topics: Cell Cycle; Cell Line; Chromosomes; Drug Resistance; Genes, Dominant; Metaphase; Methotrexate; Mutation; Ouabain; Tetrahydrofolate Dehydrogenase	1977
Cell-cycle dependency of BUdR-induced mutation for six genetic markers in cultured mammalian cells. Mutation research, 1979, Volume: 60, Issue:1 Topics: Animals; Asparagine; Bromodeoxyuridine; Cell Cycle; Cytarabine; DNA; Drug Resistance; Genes; L Cells; Methotrexate; Mice; Mutation; Ouabain; Thioguanine; Thymidine	1979
Folic acid transport by mammalian small intestine. The American journal of physiology, 1978, Volume: 235, Issue:6 Topics: Animals; Biological Transport, Active; Cell Membrane; Cricetinae; Folic Acid; Intestine, Small; Male; Methotrexate; Microvilli; Ouabain; Rats; Sodium	1978
A functional, active transport system for methotrexate in freshly isolated hepatocytes. Biochemical and biophysical research communications, 1976, Jan-12, Volume: 68, Issue:1 Topics: Animals; Arsenic; Biological Transport, Active; Dinitrophenols; Folic Acid; In Vitro Techniques; Iodoacetamide; Kinetics; Leucovorin; Liver; Male; Methotrexate; Ouabain; Perfusion; Rats	1976
Ethyl methanesulphonate mutagenesis with L5178Y mouse lymphoma cells: a comparison of ouabain, thioguanine and excess thymidine resistance. Mutation research, 1976, Volume: 34, Issue:3 Topics: Animals; Cell Survival; Clone Cells; Cytarabine; Dose-Response Relationship, Drug; Drug Resistance; Ethyl Methanesulfonate; Genetic Variation; Methotrexate; Mice; Mice, Inbred DBA; Mutation; Ouabain; Thioguanine; Thymidine	1976
High frequency of double drug resistance in the B16 melanoma cell line. European journal of cancer (Oxford, England : 1990), 1990, Volume: 26, Issue:5 Topics: Amides; Animals; Antineoplastic Agents; Aspartic Acid; Cell Line; Colony-Forming Units Assay; Drug Resistance; Drug Synergism; Gene Amplification; Melanoma; Methotrexate; Mice; Ouabain; Phosphonoacetic Acid; Pyrazoles; Ribonucleosides; Ribose	1990
Hamster cells with increased rates of DNA amplification, a new phenotype. Cell, 1987, Mar-13, Volume: 48, Issue:5 Topics: Amides; Animals; Antimetabolites, Antineoplastic; Aspartic Acid; Cell Line; Coformycin; Cricetinae; DNA; Drug Resistance; Gene Amplification; Genes; Kidney; Methotrexate; Mutation; Ouabain; Phenotype; Phosphonoacetic Acid; Pyrazoles; Ribonucleosides; Ribose; Tetrahydrofolate Dehydrogenase	1987
The estimation of enzyme activity in living epidermal cells. The British journal of dermatology, 1974, Volume: 91, Issue:5 Topics: Animals; Aspartate Aminotransferases; Chemistry Techniques, Analytical; Cytoplasm; Epithelial Cells; Epithelium; Forearm; Glycolysis; Guinea Pigs; Humans; In Vitro Techniques; Isocitrate Dehydrogenase; L-Lactate Dehydrogenase; Liver; Malate Dehydrogenase; Malates; Methotrexate; Mitochondria; NAD; NADP; Ouabain; Oxygen; Prednisolone; Psoriasis; Pyruvate Kinase; Skin; Spectrophotometry	1974
Studies on the malabsorption syndromes. Inhibition of (Na+-K+) ATPase of small intestine microvilli by pyrrolidone carboxylic acid. Clinica chimica acta; international journal of clinical chemistry, 1973, Dec-12, Volume: 49, Issue:2 Topics: Adenosine Triphosphatases; Amino Acids; Animals; Duodenum; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Kinetics; Malabsorption Syndromes; Male; Methotrexate; Organ Specificity; Ouabain; Potassium; Pyrrolidinones; Pyrrolidonecarboxylic Acid; Rats; Sodium; Structure-Activity Relationship	1973
Uptake and metabolism of N 5 -formyltetrahydrofolate by L1210 leukemia cells. Cancer research, 1972, Volume: 32, Issue:7 Topics: Animals; Carbon Isotopes; Chloromercuribenzoates; Chromatography, Gel; Coenzymes; Depression, Chemical; Fluorides; Folic Acid; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetates; Leukemia L1210; Methotrexate; Mice; Ouabain; Tetrahydrofolates; Tritium	1972
Specific binding of cortisol in subcellular fractions of HeLa cells: temperature dependence and effects of inhibitors. Endocrinology, 1971, Volume: 88, Issue:2 Topics: 17-Hydroxycorticosteroids; Arsenicals; Azides; Binding Sites; Cell Nucleus; Chloramphenicol; Cyanides; Cycloheximide; Cytoplasm; Dactinomycin; Depression, Chemical; Dinitrophenols; Female; Fluorouracil; HeLa Cells; Hexoses; Humans; Hydrocortisone; In Vitro Techniques; Iodoacetates; Methotrexate; Microsomes; Mitochondria; Ouabain; Prednisolone; Puromycin; Temperature; Tritium	1971
Uptake of methotrexate-3H by rabbit kidney slices. Cancer research, 1967, Volume: 27, Issue:3 Topics: Acetazolamide; Animals; Antimetabolites; Biological Transport, Active; Dinitrophenols; Fluorides; In Vitro Techniques; Iodoacetates; Kidney; Mercury; Methazolamide; Methotrexate; Ouabain; Rabbits; Tritium	1967
Transport, binding, and polyglutamation of methotrexate in freshly isolated rat hepatocytes. Cancer research, 1980, Volume: 40, Issue:3 Topics: 4-Chloromercuribenzenesulfonate; Animals; Azides; Biological Transport, Active; Cells, Cultured; Folic Acid; Liver; Male; Methotrexate; Ouabain; Polyglutamic Acid; Rats; Temperature	1980
Transport of methotrexate in cortical slices of monkey kidney: effect of organic anions and vincristine. The Journal of pharmacology and experimental therapeutics, 1983, Volume: 226, Issue:3 Topics: 2,4-Dinitrophenol; Aminohippuric Acids; Animals; Aspirin; Biological Transport; Dinitrophenols; Female; Folic Acid; Kidney Cortex; Kinetics; Leucovorin; Macaca fascicularis; Macaca mulatta; Male; Methotrexate; Ouabain; p-Aminohippuric Acid; Vincristine	1983