ouabagenin has been researched along with butenolide* in 1 studies
1 other study(ies) available for ouabagenin and butenolide
Article | Year |
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Total synthesis of ouabagenin and ouabain.
A full account of the total synthesis of ouabagenin and ouabain is described. A highly stereocontrolled anionic cycloaddition for the rapid construction of the basic steroid skeleton is a pivotal conversion for the whole strategy. A careful study was needed to establish the order and the sequence of functional group manipulations. Specific conformational features of the ouabain skeleton allowed us to overcome a few stereochemical problems. Degradation studies on ouabain provided an ultimate proof for a key intermediate, which is used as a relay. Late stage butenolide formation and glycosidation yielded ouabain. Topics: 4-Butyrolactone; Crystallography, X-Ray; Cyclization; Ouabain; Oxidation-Reduction; Stereoisomerism | 2009 |