ouabagenin and butenolide

ouabagenin has been researched along with butenolide* in 1 studies

Other Studies

1 other study(ies) available for ouabagenin and butenolide

Article	Year
Total synthesis of ouabagenin and ouabain. Chemistry, an Asian journal, 2009, May-04, Volume: 4, Issue:5 A full account of the total synthesis of ouabagenin and ouabain is described. A highly stereocontrolled anionic cycloaddition for the rapid construction of the basic steroid skeleton is a pivotal conversion for the whole strategy. A careful study was needed to establish the order and the sequence of functional group manipulations. Specific conformational features of the ouabain skeleton allowed us to overcome a few stereochemical problems. Degradation studies on ouabain provided an ultimate proof for a key intermediate, which is used as a relay. Late stage butenolide formation and glycosidation yielded ouabain. Topics: 4-Butyrolactone; Crystallography, X-Ray; Cyclization; Ouabain; Oxidation-Reduction; Stereoisomerism	2009

Article

Year

Total synthesis of ouabagenin and ouabain.

Chemistry, an Asian journal, 2009, May-04, Volume: 4, Issue:5

A full account of the total synthesis of ouabagenin and ouabain is described. A highly stereocontrolled anionic cycloaddition for the rapid construction of the basic steroid skeleton is a pivotal conversion for the whole strategy. A careful study was needed to establish the order and the sequence of functional group manipulations. Specific conformational features of the ouabain skeleton allowed us to overcome a few stereochemical problems. Degradation studies on ouabain provided an ultimate proof for a key intermediate, which is used as a relay. Late stage butenolide formation and glycosidation yielded ouabain.

Topics: 4-Butyrolactone; Crystallography, X-Ray; Cyclization; Ouabain; Oxidation-Reduction; Stereoisomerism

2009