otamixaban and premafloxacin

otamixaban has been researched along with premafloxacin* in 1 studies

Other Studies

1 other study(ies) available for otamixaban and premafloxacin

Article	Year
Asymmetric synthesis of intermediates for otamixaban and premafloxacin by the chiral ligand-controlled asymmetric conjugate addition of a lithium amide. The Journal of organic chemistry, 2006, Jun-09, Volume: 71, Issue:12 A chiral ligand-controlled conjugate addition reaction of lithium benzyl(trimethylsilyl)amide with tert-butyl enoates gave the corresponding lithium enolates that were then treated with electrophiles, giving anti-alkylation products with high ee up to 98%. The benzyl group on the amino nitrogen was removed by the oxidation of secondary amines to imines and subsequent transoximation to give 3-aminoalkanoates in good yields. The products are the possible key intermediates of otamixaban and premafloxacin. Topics: Amides; Cyclic N-Oxides; Fluoroquinolones; Ligands; Lithium; Pyridines; Pyrroles; Quinolones; Stereoisomerism	2006

Article

Year

Asymmetric synthesis of intermediates for otamixaban and premafloxacin by the chiral ligand-controlled asymmetric conjugate addition of a lithium amide.

The Journal of organic chemistry, 2006, Jun-09, Volume: 71, Issue:12

A chiral ligand-controlled conjugate addition reaction of lithium benzyl(trimethylsilyl)amide with tert-butyl enoates gave the corresponding lithium enolates that were then treated with electrophiles, giving anti-alkylation products with high ee up to 98%. The benzyl group on the amino nitrogen was removed by the oxidation of secondary amines to imines and subsequent transoximation to give 3-aminoalkanoates in good yields. The products are the possible key intermediates of otamixaban and premafloxacin.

Topics: Amides; Cyclic N-Oxides; Fluoroquinolones; Ligands; Lithium; Pyridines; Pyrroles; Quinolones; Stereoisomerism

2006