osteum and cholest-8(14)-en-3-ol-15-one

osteum has been researched along with cholest-8(14)-en-3-ol-15-one* in 1 studies

Other Studies

1 other study(ies) available for osteum and cholest-8(14)-en-3-ol-15-one

Article	Year
Inhibitors of sterol synthesis. Exogenous oleate reduces the inhibitory effect of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on the growth of CHO-K1 cells. Biochemical and biophysical research communications, 1988, Oct-31, Volume: 156, Issue:2 5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a hypocholesterolemic agent and a potent inhibitor of sterol biosynthesis, inhibited the growth of CHO-K1 cells incubated in medium containing fetal calf serum. The concentration of the oxysterol required to inhibit growth by 50% was 13 microM. Sodium oleate (82 microM) reduced the inhibitory effects of the sterol, and increased the concentration of the 15-ketosterol required to cause a 50% inhibition of growth to 25 microM. The ACAT inhibitor N'-(2,4-difluoro-phenyl)-N-[4-(2,2-dimethylpropy)-phenyl]-methyl)- N- heptylurea (5 microM) abolished the effect of sodium oleate, and reduced the concentration of the 15-ketosterol required to inhibit growth by 50% to 5 microM. Topics: Animals; Anticholesteremic Agents; Cell Division; Cell Line; Cholestenes; Cholestenones; Cricetinae; Female; Oleic Acid; Oleic Acids; Ovary; Protein Biosynthesis; Sterol O-Acyltransferase; Sterols	1988

Article

Year

Inhibitors of sterol synthesis. Exogenous oleate reduces the inhibitory effect of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one on the growth of CHO-K1 cells.

Biochemical and biophysical research communications, 1988, Oct-31, Volume: 156, Issue:2

5 alpha-Cholest-8(14)-en-3 beta-ol-15-one, a hypocholesterolemic agent and a potent inhibitor of sterol biosynthesis, inhibited the growth of CHO-K1 cells incubated in medium containing fetal calf serum. The concentration of the oxysterol required to inhibit growth by 50% was 13 microM. Sodium oleate (82 microM) reduced the inhibitory effects of the sterol, and increased the concentration of the 15-ketosterol required to cause a 50% inhibition of growth to 25 microM. The ACAT inhibitor N'-(2,4-difluoro-phenyl)-N-[4-(2,2-dimethylpropy)-phenyl]-methyl)- N- heptylurea (5 microM) abolished the effect of sodium oleate, and reduced the concentration of the 15-ketosterol required to inhibit growth by 50% to 5 microM.

Topics: Animals; Anticholesteremic Agents; Cell Division; Cell Line; Cholestenes; Cholestenones; Cricetinae; Female; Oleic Acid; Oleic Acids; Ovary; Protein Biosynthesis; Sterol O-Acyltransferase; Sterols

1988