Page last updated: 2024-08-24

oseltamivir and vx-787

oseltamivir has been researched along with vx-787 in 8 studies

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (50.00)24.3611
2020's4 (50.00)2.80

Authors

AuthorsStudies
Bandarage, UK; Bennani, YL; Bennett, HB; Bethiel, RS; Boyd, MJ; Bral, C; Byrn, RA; Charifson, PS; Clark, MP; Court, JJ; Davies, I; Deng, H; Dorsch, WA; Duffy, JP; Farmer, LJ; Gao, H; Germann, U; Gu, W; Jackson, K; Jacobs, DH; Jacobs, M; Jiang, M; Jones, SM; Kennedy, JM; Ledeboer, MW; Ledford, B; Leeman, JR; Liang, J; Maltais, F; McNeil, C; Memmott, C; Murcko, M; Nezami, A; Nti-Addae, K; Perola, E; Rijnbrand, R; Salituro, FG; Taylor, WP; Tsai, A; Wang, T; Wannamaker, MW; Zhang, Y1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Barnard, DL; Jones, SM; Smee, DF1
Deleu, S; Hillewaert, V; Hoetelmans, RMW; Kakuda, TN; Leopold, L; Lwin, A; Spittaels, K; Vercauteren, JJ1
Anderson, D; Finberg, RW; Fleischhackl, R; Kauffman, RS; Kosoglou, T; Lanno, R; Leopold, L; van Duijnhoven, W; Vingerhoets, J1
Martin-Loeches, I; O'Sullivan, S; Rodriguez, A; Torres, A1
Anderson, D; Deleu, S; Hallouin-Bernard, MC; Ison, MG; Kosoglou, T; Leopold, L; Nilsson, AC; O'Neil, B; Rossenu, S; Torres, A; Van Dromme, I; van Duijnhoven, W; Vingerhoets, J; Wilburn, JM1
Anderson, D; De Meyer, S; Leopold, L; Van Dromme, I; van Duijnhoven, W; Vingerhoets, J1

Reviews

1 review(s) available for oseltamivir and vx-787

ArticleYear
Influenza management with new therapies.
    Current opinion in pulmonary medicine, 2020, Volume: 26, Issue:3

    Topics: Adrenal Cortex Hormones; Amides; Antiviral Agents; Critical Care; Critical Illness; Dibenzothiepins; Enzyme Inhibitors; Humans; Influenza, Human; Morpholines; Neuraminidase; Oseltamivir; Pyrazines; Pyridines; Pyridones; Pyrimidines; Pyrroles; Respiration, Artificial; Triazines; Zanamivir

2020

Trials

4 trial(s) available for oseltamivir and vx-787

ArticleYear
Single- and multiple-dose pharmacokinetics and safety of pimodivir, a novel, non-nucleoside polymerase basic protein 2 subunit inhibitor of the influenza A virus polymerase complex, and interaction with oseltamivir: a Phase 1 open-label study in healthy v
    British journal of clinical pharmacology, 2018, Volume: 84, Issue:11

    Topics: Adolescent; Adult; Antiviral Agents; Area Under Curve; Cross-Over Studies; Diarrhea; Double-Blind Method; Drug Interactions; Female; Humans; Male; Middle Aged; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Time Factors; Young Adult

2018
Phase 2b Study of Pimodivir (JNJ-63623872) as Monotherapy or in Combination With Oseltamivir for Treatment of Acute Uncomplicated Seasonal Influenza A: TOPAZ Trial.
    The Journal of infectious diseases, 2019, 03-15, Volume: 219, Issue:7

    Topics: Acute Disease; Adult; Antiviral Agents; Diarrhea; Double-Blind Method; Drug Resistance, Viral; Drug Therapy, Combination; Early Termination of Clinical Trials; Female; Humans; Influenza A virus; Influenza, Human; Male; Middle Aged; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Time Factors; Viral Load; Viral Proteins; Virus Shedding

2019
A Phase 2 Study of Pimodivir (JNJ-63623872) in Combination With Oseltamivir in Elderly and Nonelderly Adults Hospitalized With Influenza A Infection: OPAL Study.
    The Journal of infectious diseases, 2022, 08-12, Volume: 226, Issue:1

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antiviral Agents; Humans; Influenza, Human; Middle Aged; Oseltamivir; Pyridines; Pyrroles; Treatment Outcome; Young Adult

2022
Genotypic and phenotypic characterization of influenza A viral variants in study participants treated with pimodivir in the phase 2b TOPAZ study.
    Antiviral therapy, 2023, Volume: 28, Issue:3

    Topics: Adult; Antiviral Agents; Genotype; Humans; Influenza A virus; Influenza, Human; Oseltamivir

2023

Other Studies

3 other study(ies) available for oseltamivir and vx-787

ArticleYear
Discovery of a novel, first-in-class, orally bioavailable azaindole inhibitor (VX-787) of influenza PB2.
    Journal of medicinal chemistry, 2014, Aug-14, Volume: 57, Issue:15

    Topics: Administration, Oral; Animals; Antiviral Agents; Aza Compounds; Biological Availability; Dogs; Drug Resistance, Viral; Indoles; Influenza A virus; Madin Darby Canine Kidney Cells; Male; Mice, Inbred BALB C; Models, Molecular; Molecular Structure; Orthomyxoviridae Infections; Rats; RNA-Dependent RNA Polymerase; Species Specificity; Stereoisomerism; Structure-Activity Relationship; Viral Proteins; Virus Replication

2014
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice.
    Antiviral research, 2016, Volume: 136

    Topics: Animals; Antiviral Agents; Drug Discovery; Drug Therapy, Combination; Indoles; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Lung; Mice; Orthomyxoviridae Infections; Oseltamivir; Pyridines; Pyrimidines; Pyrroles; Viral Load; Virus Replication

2016