Page last updated: 2024-09-04

orotidylic acid and uridine monophosphate

orotidylic acid has been researched along with uridine monophosphate in 53 studies

Compound Research Comparison

Studies (orotidylic acid)	Trials (orotidylic acid)	Recent Studies (post-2010) (orotidylic acid)	Studies (uridine monophosphate)	Trials (uridine monophosphate)	Recent Studies (post-2010) (uridine monophosphate)
54	0	10	1,439	97	691

Research

Studies (53)

Timeframe	Studies, this research(%)	All Research%
pre-1990	11 (20.75)	18.7374
1990's	5 (9.43)	18.2507
2000's	26 (49.06)	29.6817
2010's	10 (18.87)	24.3611
2020's	1 (1.89)	2.80

Authors

Authors	Studies
Rawls, JM	1
Behrens, ND; Hupe, DJ	1
Traut, TW	1
West, TP	1
McClard, RW; Shokat, KM	1
Ashton, RW; Sloan, DL	1
Cha, S; El Kouni, MH	1
Rathod, PK; Reyes, P	1
Grubmeyer, C; Ozturk, DH; Sacchettini, JC; Scapin, G	1
Dorfman, RH; Grubmeyer, C; Ozturk, DH; Sacchettini, JC; Scapin, G	1
Blanchard, JS; Grubmeyer, C; Tao, W	1
Houk, KN; Lee, JK	1
Grubmeyer, C; Jensen, KF; Lundegaard, C; Wang, GP	1
Harris, P; Jensen, KF; Larsen, S; Navarro Poulsen, JC	1
Cleland, WW; Rishavy, MA	1
Miller, BG; Short, SA; Snider, MJ; Wolfenden, R	1
Porter, DJ; Short, SA	1
Florián, J; Strajbl, M; Villà, J; Warshel, A	1
Butterfoss, GL; Miller, BG; Short, SA; Wolfenden, R	1
Chodera, JD; Chong, LT; Kollman, PA; Lee, TS	1
Harris, P; Jensen, KF; Larsen, S; Poulsen, JC	1
Bruice, TC; Hur, S	1
Blomberg, MR; Lundberg, M; Siegbahn, PE	1
DelFraino, BJ; Simpson, BA; Smiley, JA	1
Gao, J	1
Bedell, VM; Dacres, JE; Kass, SR; Lis, L; Wang, LS; Wang, XB; Yang, X	1
HANDSCHUMACHER, RE; PASTERNAK, CA	1
HANDSCHUMACHER, RE	1
AUSTRIAN, R; BECKWITH, JR; JACOB, F; PARDEE, AB; TAYLOR, AL	1
Callahan, BP; Wolfenden, R	1
Carloni, P; Cascella, M; Raugei, S	1
Holets, EA; MacKinnon, AL; McClard, RW; Witte, JF	1
Callahan, BP; Miller, BG	1
Amyes, TL; Chan, K; Gerlt, JA; Richard, JP; Toth, K; Wood, BM	2
Ma, C; Wang, X; Xu, P	1
Houk, KN; Kuo, IF; Laino, T; Mundy, CJ; Stanton, CL	1
Horii, T; Inoue, T; Kai, Y; Krungkrai, J; Krungkrai, SR; Kusakari, Y; Matsumura, H; Tokuoka, K	1
Amyes, TL; Barnett, SA; Gerlt, JA; Richard, JP; Wood, BM	1
Boone, A; Hu, H; Yang, W	1
Lee, JK; Phillips, LM; Smiley, JA; Smiley, VL; Vemulapalli, B; Wepukhulu, WO	1
Diederichsen, U; Heinrich, D; Rudolph, MG	1
Kanchanaphum, P; Krungkrai, J	1
Amyes, TL; Goryanova, B; Richard, JP; Spong, K	1
Barr, EW; Cheng, H; Girvin, ME; Grubmeyer, C; Hansen, MR; Harris, R	1
Bao, L; Harris, SD; Hu, C; Jin, C; Li, S; Liu, H; Sun, X; Zhu, J	1
Amyes, TL; Gerlt, JA; Goldman, LM; Goryanova, B; Richard, JP	1
Barr, EW; Grubmeyer, C; Hansen, MR; Jensen, KF; Willemoës, M; Winther, JR	1
Jalili, S; Jamshidi, S; Rafii-Tabar, H	1
Amyes, TL; Gerlt, JA; Goldman, LM; Goryanova, B; Ming, S; Richard, JP	1
Deshpande, PA; Subrahmanyeswara Rao, NN	1
Brandt, GS; Kirkman, LMD; Novak, WRP; West, KHJ	1
Richard, JP	1

Reviews

2 review(s) available for orotidylic acid and uridine monophosphate

Article	Year
Catalysis by enzyme conformational change as illustrated by orotidine 5'-monophosphate decarboxylase. Current opinion in structural biology, 2003, Volume: 13, Issue:2 Topics: Binding Sites; Catalysis; Computer Simulation; Energy Transfer; Enzyme Activation; Enzyme Stability; Models, Chemical; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Protein Binding; Protein Conformation; Substrate Specificity; Uridine Monophosphate	2003
OMP decarboxylase--An enigma persists. Bioorganic chemistry, 2007, Volume: 35, Issue:6 Topics: Catalysis; Orotidine-5'-Phosphate Decarboxylase; Uridine Monophosphate; Yeasts	2007

Article

Year

Catalysis by enzyme conformational change as illustrated by orotidine 5'-monophosphate decarboxylase.

Current opinion in structural biology, 2003, Volume: 13, Issue:2

Topics: Binding Sites; Catalysis; Computer Simulation; Energy Transfer; Enzyme Activation; Enzyme Stability; Models, Chemical; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Protein Binding; Protein Conformation; Substrate Specificity; Uridine Monophosphate

2003

OMP decarboxylase--An enigma persists.

Bioorganic chemistry, 2007, Volume: 35, Issue:6

Topics: Catalysis; Orotidine-5'-Phosphate Decarboxylase; Uridine Monophosphate; Yeasts

2007

Other Studies

51 other study(ies) available for orotidylic acid and uridine monophosphate

Article	Year
Enzymatic synthesis of [6-14C]orotidine 5'-monophosphate and its use in the assay of orotate phosphoribosyltransferase and orotidylate decarboxylase. Analytical biochemistry, 1978, Volume: 86, Issue:1 Topics: Carboxy-Lyases; Drosophila; Microchemistry; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pentosyltransferases; Ribonucleotides; Uridine Monophosphate	1978
A method for assaying orotate phosphoribosyltransferase and measuring phosphoribosylpyrophosphate. Analytical biochemistry, 1987, Feb-15, Volume: 161, Issue:1 Topics: Animals; Cattle; Cells, Cultured; Cellulose; Methods; Orotate Phosphoribosyltransferase; Orotic Acid; Pentosephosphates; Pentosyltransferases; Phosphoribosyl Pyrophosphate; Polyethyleneimine; Uridine Monophosphate	1987
Uridine-5'-phosphate synthase: evidence for substrate cycling involving this bifunctional protein. Archives of biochemistry and biophysics, 1989, Volume: 268, Issue:1 Topics: Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Kinetics; Mice; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pentosyltransferases; Uridine Monophosphate	1989
Effect of pyrophosphate and orotidine monophosphate on cytosine deaminase regulatory properties. Experientia, 1985, Dec-15, Volume: 41, Issue:12 Topics: Allosteric Regulation; Bacterial Proteins; Binding, Competitive; Cytosine Deaminase; Diphosphates; Kinetics; Nucleoside Deaminases; Salmonella typhimurium; Uracil Nucleotides; Uridine Monophosphate	1985
Does the bifunctional uridylate synthase channel orotidine 5'-phosphate? Kinetics of orotate phosphoribosyltransferase and orotidylate decarboxylase activities fit a noninteracting sites model. Biochemistry, 1987, Jun-16, Volume: 26, Issue:12 Topics: Carboxy-Lyases; Kinetics; Models, Theoretical; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Pentosyltransferases; Time Factors; Uracil Nucleotides; Uridine Monophosphate	1987
Enzymatic coupled assay procedures that employ high-performance liquid chromatography: the synthesis of orotidylate from ribose. Journal of chromatography, 1984, Dec-28, Volume: 317 Topics: Bacterial Proteins; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Pentosephosphates; Phosphoribosyl Pyrophosphate; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Ribose; Ribose-Phosphate Pyrophosphokinase; Salmonella typhimurium; Uracil Nucleotides; Uridine Monophosphate	1984
Isolation and partial characterization of a 5'-nucleotidase specific for orotidine-5'-monophosphate. Proceedings of the National Academy of Sciences of the United States of America, 1982, Volume: 79, Issue:4 Topics: 5'-Nucleotidase; Animals; Concanavalin A; Dithionitrobenzoic Acid; Kinetics; Magnesium; Male; Mice; Microsomes; Nucleotidases; Orotate Phosphoribosyltransferase; Pentosyltransferases; Rats; Sodium Fluoride; Substrate Specificity; Tissue Distribution; Uracil Nucleotides; Uridine Monophosphate	1982
Orotidylate-metabolizing enzymes of the human malarial parasite, Plasmodium falciparum, differ from host cell enzymes. The Journal of biological chemistry, 1983, Mar-10, Volume: 258, Issue:5 Topics: Animals; Carboxy-Lyases; Erythrocytes; Humans; Kinetics; Malaria; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Pentosyltransferases; Plasmodium falciparum; Uracil Nucleotides; Uridine Monophosphate	1983
The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and alpha-D-5-phosphoribosyl-1-pyrophosphate. Biochemistry, 1995, Aug-29, Volume: 34, Issue:34 Topics: Binding Sites; Computer Graphics; Crystallization; Crystallography, X-Ray; Models, Molecular; Molecular Structure; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Protein Conformation; Protein Structure, Tertiary; Salmonella typhimurium; Uridine Monophosphate	1995
Locations and functional roles of conserved lysine residues in Salmonella typhimurium orotate phosphoribosyltransferase. Biochemistry, 1995, Aug-29, Volume: 34, Issue:34 Topics: Base Sequence; Binding Sites; Computer Graphics; Diphosphates; Enzyme Inhibitors; Enzyme Stability; Kinetics; Lysine; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Orotate Phosphoribosyltransferase; Phosphoribosyl Pyrophosphate; Protein Binding; Protein Structure, Tertiary; Salmonella typhimurium; Substrate Specificity; Uridine Monophosphate	1995
Transition state structure of Salmonella typhimurium orotate phosphoribosyltransferase. Biochemistry, 1996, Jan-09, Volume: 35, Issue:1 Topics: Carbon Radioisotopes; Diphosphates; Hydrogen Bonding; Isotope Labeling; Kinetics; Models, Molecular; Molecular Conformation; Orotate Phosphoribosyltransferase; Protein Structure, Secondary; Salmonella typhimurium; Tritium; Uridine Monophosphate	1996
A proficient enzyme revisited: the predicted mechanism for orotidine monophosphate decarboxylase. Science (New York, N.Y.), 1997, May-09, Volume: 276, Issue:5314 Topics: Barbiturates; Binding Sites; Catalysis; Decarboxylation; Enzyme Inhibitors; Hydrogen-Ion Concentration; Kinetics; Orotidine-5'-Phosphate Decarboxylase; Protons; Thermodynamics; Uridine Monophosphate	1997
Kinetic mechanism of OMP synthase: a slow physical step following group transfer limits catalytic rate. Biochemistry, 1999, Jan-05, Volume: 38, Issue:1 Topics: Binding Sites; Catalysis; Kinetics; Ligands; Orotate Phosphoribosyltransferase; Phosphoribosyl Pyrophosphate; Phosphorus Radioisotopes; Salmonella typhimurium; Uridine Monophosphate; Viscosity	1999
Structural basis for the catalytic mechanism of a proficient enzyme: orotidine 5'-monophosphate decarboxylase. Biochemistry, 2000, Apr-18, Volume: 39, Issue:15 Topics: Amino Acid Sequence; Binding Sites; Catalysis; Conserved Sequence; Crystallography, X-Ray; Dimerization; Escherichia coli; Hydrogen Bonding; Models, Chemical; Models, Molecular; Molecular Sequence Data; Orotidine-5'-Phosphate Decarboxylase; Protein Structure, Secondary; Sequence Alignment; Structure-Activity Relationship; Uridine Monophosphate	2000
Determination of the mechanism of orotidine 5'-monophosphate decarboxylase by isotope effects. Biochemistry, 2000, Apr-25, Volume: 39, Issue:16 Topics: Ammonia; Catalysis; Chromatography, High Pressure Liquid; Ethylene Glycol; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Kinetics; Magnetic Resonance Spectroscopy; Nitrogen; Nitrogen Isotopes; Orotidine-5'-Phosphate Decarboxylase; Picolinic Acids; Protons; Static Electricity; Uridine Monophosphate	2000
Contribution of enzyme-phosphoribosyl contacts to catalysis by orotidine 5'-phosphate decarboxylase. Biochemistry, 2000, Jul-18, Volume: 39, Issue:28 Topics: Binding, Competitive; Catalysis; Decarboxylation; Escherichia coli; Mutagenesis, Site-Directed; Orotidine-5'-Phosphate Decarboxylase; Protein Conformation; Saccharomyces cerevisiae; Substrate Specificity; Uridine Monophosphate	2000
Yeast orotidine-5'-phosphate decarboxylase: steady-state and pre-steady-state analysis of the kinetic mechanism of substrate decarboxylation. Biochemistry, 2000, Sep-26, Volume: 39, Issue:38 Topics: Binding Sites; Catalysis; Decarboxylation; Dimerization; Hydrogen-Ion Concentration; Kinetics; Ligands; Orotidine-5'-Phosphate Decarboxylase; Protons; Saccharomyces cerevisiae; Sodium Chloride; Spectrometry, Fluorescence; Substrate Specificity; Uridine Monophosphate	2000
Remarkable rate enhancement of orotidine 5'-monophosphate decarboxylase is due to transition-state stabilization rather than to ground-state destabilization. Biochemistry, 2000, Dec-05, Volume: 39, Issue:48 Topics: Catalysis; Catalytic Domain; Computer Simulation; Energy Metabolism; Kinetics; Models, Chemical; Orotidine-5'-Phosphate Decarboxylase; Thermodynamics; Uridine Monophosphate	2000
Role of enzyme-ribofuranosyl contacts in the ground state and transition state for orotidine 5'-phosphate decarboxylase: a role for substrate destabilization? Biochemistry, 2001, May-29, Volume: 40, Issue:21 Topics: Alanine; Aspartic Acid; Catalysis; Enzyme Stability; Kinetics; Orotidine-5'-Phosphate Decarboxylase; Ribosemonophosphates; Saccharomyces cerevisiae; Substrate Specificity; Threonine; Uridine Monophosphate	2001
An alternative explanation for the catalytic proficiency of orotidine 5'-phosphate decarboxylase. Journal of the American Chemical Society, 2001, Dec-26, Volume: 123, Issue:51 Topics: Catalysis; Computer Simulation; Kinetics; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Protein Conformation; Protons; Thermodynamics; Uridine Monophosphate	2001
Substrate binding induces domain movements in orotidine 5'-monophosphate decarboxylase. Journal of molecular biology, 2002, May-10, Volume: 318, Issue:4 Topics: Binding Sites; Crystallography, X-Ray; Escherichia coli; Methanobacterium; Models, Chemical; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Protein Structure, Secondary; Protein Structure, Tertiary; Saccharomyces cerevisiae; Substrate Specificity; Uridine Monophosphate	2002
Molecular dynamic study of orotidine-5'-monophosphate decarboxylase in ground state and in intermediate state: a role of the 203-218 loop dynamics. Proceedings of the National Academy of Sciences of the United States of America, 2002, Jul-23, Volume: 99, Issue:15 Topics: Binding Sites; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Oxygen; Peptide Fragments; Protein Conformation; Saccharomyces cerevisiae; Static Electricity; Uridine Monophosphate	2002
Density functional models of the mechanism for decarboxylation in orotidine decarboxylase. Journal of molecular modeling, 2002, Volume: 8, Issue:4 Topics: Carboxy-Lyases; Decarboxylation; Kinetics; Models, Molecular; Molecular Conformation; Orotidine-5'-Phosphate Decarboxylase; Uridine Monophosphate; X-Ray Diffraction	2002
Hydrogen isotope tracing in the reaction of orotidine-5'-monophosphate decarboxylase. Archives of biochemistry and biophysics, 2003, Apr-15, Volume: 412, Issue:2 Topics: Catalysis; Deuterium; Hydrogen; Models, Chemical; Nuclear Magnetic Resonance, Biomolecular; Orotidine-5'-Phosphate Decarboxylase; Saccharomyces cerevisiae; Uridine Monophosphate	2003
Photodetachment of zwitterions: probing intramolecular Coulomb repulsion and attraction in the gas phase using mono-decarboxylated pyridinium dicarboxylates. Implications on the mechanism of orotidine 5'-monophosphate decarboxylase. Journal of the American Chemical Society, 2003, Jun-04, Volume: 125, Issue:22 Topics: Computer Simulation; Dicarboxylic Acids; Ions; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Photochemistry; Pyridinium Compounds; Spectrum Analysis; Static Electricity; Thermodynamics; Uridine Monophosphate	2003
Inhibition of orotidylic acid decarboxylase, a primary site of carcinostasis by 6-azauracil. Biochimica et biophysica acta, 1958, Volume: 30, Issue:2 Topics: Antineoplastic Agents; Carboxy-Lyases; Lyases; Uracil; Uridine Monophosphate	1958
Orotidylic acid decarboxylase: inhibition studies with azauridine 5'-phosphate. The Journal of biological chemistry, 1960, Volume: 235 Topics: Azauridine; Carboxy-Lyases; Lyases; Nucleosides; Nucleotides; Phosphates; Research; Uridine Monophosphate	1960
THE CHROMOSOMAL LOCATION OF THE STRUCTURAL GENE FOR OROTIDYLIC ACID PYROPHOSPHORYLASE IN ESCHERICHIA COLI. Journal of molecular biology, 1964, Volume: 8 Topics: Chromosomes; Escherichia coli; Genes; Mannitol; Mutation; Pyrimidines; Research; Transferases; Uridine Monophosphate	1964
OMP decarboxylase: an experimental test of electrostatic destabilization of the enzyme-substrate complex. Journal of the American Chemical Society, 2004, Nov-17, Volume: 126, Issue:45 Topics: Enzyme Stability; Hydrogen-Ion Concentration; Kinetics; Ligands; Nuclear Magnetic Resonance, Biomolecular; Orotidine-5'-Phosphate Decarboxylase; Static Electricity; Uridine Monophosphate	2004
A proficient enzyme: insights on the mechanism of orotidine monophosphate decarboxylase from computer simulations. Journal of the American Chemical Society, 2004, Dec-08, Volume: 126, Issue:48 Topics: Computer Simulation; Enzyme Stability; Escherichia coli; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Protein Conformation; Quantum Theory; Saccharomyces cerevisiae; Thermodynamics; Uridine Monophosphate	2004
Half-of-sites binding of orotidine 5'-phosphate and alpha-D-5-phosphorylribose 1-diphosphate to orotate phosphoribosyltransferase from Saccharomyces cerevisiae supports a novel variant of the Theorell-Chance mechanism with alternating site catalysis. Biochemistry, 2006, Apr-25, Volume: 45, Issue:16 Topics: Binding Sites; Calorimetry; Catalysis; Chromatography, Gel; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Structure; Orotate Phosphoribosyltransferase; Phosphoribosyl Pyrophosphate; Saccharomyces cerevisiae; Substrate Specificity; Titrimetry; Uridine Monophosphate	2006
Product deuterium isotope effect for orotidine 5'-monophosphate decarboxylase: evidence for the existence of a short-lived carbanion intermediate. Journal of the American Chemical Society, 2007, Oct-31, Volume: 129, Issue:43 Topics: Carbon; Deuterium; Magnetic Resonance Spectroscopy; Molecular Structure; Orotidine-5'-Phosphate Decarboxylase; Uridine Monophosphate	2007
Orotate phosphoribosyltransferase from Corynebacterium ammoniagenes lacking a conserved lysine. Journal of bacteriology, 2007, Volume: 189, Issue:24 Topics: Bacterial Proteins; Cations, Divalent; Chromatography, Gel; Cloning, Molecular; Coenzymes; Conserved Sequence; Corynebacterium; Dimerization; Diphosphates; Enzyme Stability; Escherichia coli; Gene Expression; Hydrogen-Ion Concentration; Kinetics; Lysine; Molecular Sequence Data; Molecular Weight; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Recombinant Proteins; Sequence Analysis, DNA; Uridine Monophosphate	2007
QM/MM metadynamics study of the direct decarboxylation mechanism for orotidine-5'-monophosphate decarboxylase using two different QM regions: acceleration too small to explain rate of enzyme catalysis. The journal of physical chemistry. B, 2007, Nov-01, Volume: 111, Issue:43 Topics: Catalysis; Computer Simulation; Crystallography, X-Ray; Decarboxylation; Kinetics; Models, Molecular; Molecular Structure; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Quantum Theory; Software; Thermodynamics; Uridine Monophosphate	2007
Structural basis for the decarboxylation of orotidine 5'-monophosphate (OMP) by Plasmodium falciparum OMP decarboxylase. Journal of biochemistry, 2008, Volume: 143, Issue:1 Topics: Amino Acid Sequence; Animals; Apoenzymes; Binding Sites; Crystallography, X-Ray; Decarboxylation; Lysine; Models, Molecular; Molecular Sequence Data; Orotidine-5'-Phosphate Decarboxylase; Plasmodium falciparum; Protein Binding; Protein Structure, Tertiary; Protozoan Proteins; Sequence Homology, Amino Acid; Uridine Monophosphate	2008
Dissecting the total transition state stabilization provided by amino acid side chains at orotidine 5'-monophosphate decarboxylase: a two-part substrate approach. Biochemistry, 2008, Jul-29, Volume: 47, Issue:30 Topics: Amino Acids; Binding Sites; Crystallography, X-Ray; Hydrogen Bonding; Kinetics; Models, Biological; Molecular Structure; Orotidine-5'-Phosphate Decarboxylase; Substrate Specificity; Uridine Monophosphate	2008
Mechanism of OMP decarboxylation in orotidine 5'-monophosphate decarboxylase. Journal of the American Chemical Society, 2008, Nov-05, Volume: 130, Issue:44 Topics: Algorithms; Catalysis; Catalytic Domain; Computer Simulation; Crystallography, X-Ray; Decarboxylation; Kinetics; Methanobacterium; Models, Chemical; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Quantum Theory; Static Electricity; Thermodynamics; Uridine Monophosphate	2008
A substantial oxygen isotope effect at O2 in the OMP decarboxylase reaction: mechanistic implications. Organic & biomolecular chemistry, 2008, Dec-21, Volume: 6, Issue:24 Topics: Escherichia coli; Kinetics; Orotidine-5'-Phosphate Decarboxylase; Oxygen Isotopes; Uridine Monophosphate	2008
Lys314 is a nucleophile in non-classical reactions of orotidine-5'-monophosphate decarboxylase. Chemistry (Weinheim an der Bergstrasse, Germany), 2009, Jul-06, Volume: 15, Issue:27 Topics: Animals; Catalysis; Humans; Hydrolysis; Lysine; Methanobacterium; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Plasmodium falciparum; Stereoisomerism; Uridine Monophosphate	2009
Kinetic benefits and thermal stability of orotate phosphoribosyltransferase and orotidine 5'-monophosphate decarboxylase enzyme complex in human malaria parasite Plasmodium falciparum. Biochemical and biophysical research communications, 2009, Dec-11, Volume: 390, Issue:2 Topics: Animals; Enzyme Stability; Hot Temperature; Humans; Kinetics; Malaria, Falciparum; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotidine-5'-Phosphate Decarboxylase; Plasmodium falciparum; Uridine Monophosphate	2009
Product deuterium isotope effects for orotidine 5'-monophosphate decarboxylase: effect of changing substrate and enzyme structure on the partitioning of the vinyl carbanion reaction intermediate. Journal of the American Chemical Society, 2010, May-26, Volume: 132, Issue:20 Topics: Biocatalysis; Deuterium; Escherichia coli; Methanobacteriaceae; Mutation; Nuclear Magnetic Resonance, Biomolecular; Orotidine-5'-Phosphate Decarboxylase; Ribonucleotides; Saccharomyces cerevisiae; Uridine Monophosphate	2010
Catalysis by orotidine 5'-monophosphate decarboxylase: effect of 5-fluoro and 4'-substituents on the decarboxylation of two-part substrates. Biochemistry, 2013, Jan-22, Volume: 52, Issue:3 Topics: Biocatalysis; Buffers; Decarboxylation; Enzyme Activation; Enzyme Stability; Kinetics; Mutant Proteins; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Osmolar Concentration; Phosphites; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity; Uridine; Uridine Monophosphate	2013
Backbone ¹H, ¹³C, ¹⁵N NMR assignments of yeast OMP synthase in unliganded form and in complex with orotidine 5'-monophosphate. Biomolecular NMR assignments, 2014, Volume: 8, Issue:1 Topics: Amino Acid Sequence; Biocatalysis; Carbon Isotopes; Hydrogen; Ligands; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Orotate Phosphoribosyltransferase; Protein Structure, Secondary; Saccharomyces cerevisiae; Uridine Monophosphate	2014
PyrG is required for maintaining stable cellular uracil level and normal sporulation pattern under excess uracil stress in Aspergillus nidulans. Science China. Life sciences, 2013, Volume: 56, Issue:5 Topics: Aspergillus nidulans; Chromatography, High Pressure Liquid; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Microscopy, Electron, Scanning; Mutation; Orotidine-5'-Phosphate Decarboxylase; Spores, Fungal; Uracil; Uridine Monophosphate	2013
Role of a guanidinium cation-phosphodianion pair in stabilizing the vinyl carbanion intermediate of orotidine 5'-phosphate decarboxylase-catalyzed reactions. Biochemistry, 2013, Oct-22, Volume: 52, Issue:42 Topics: Crystallography, X-Ray; Decarboxylation; Deuterium; Guanidine; Kinetics; Magnetic Resonance Spectroscopy; Models, Chemical; Mutation; Orotidine-5'-Phosphate Decarboxylase; Protein Conformation; Ribonucleotides; Saccharomyces cerevisiae; Substrate Specificity; Uridine Monophosphate; Uridine Triphosphate	2013
Catalytic site interactions in yeast OMP synthase. Archives of biochemistry and biophysics, 2014, Jan-15, Volume: 542 Topics: Catalytic Domain; Escherichia coli; Kinetics; Models, Molecular; Mutation; Orotate Phosphoribosyltransferase; Phosphoribosyl Pyrophosphate; Protein Multimerization; Protein Structure, Quaternary; Saccharomyces cerevisiae; Uridine Monophosphate	2014
Study of orotidine 5'-monophosphate decarboxylase in complex with the top three OMP, BMP, and PMP ligands by molecular dynamics simulation. Journal of biomolecular structure & dynamics, 2015, Volume: 33, Issue:2 Topics: Barbiturates; Catalytic Domain; Hydrogen Bonding; Molecular Dynamics Simulation; Organophosphonates; Orotidine-5'-Phosphate Decarboxylase; Protein Binding; Protein Structure, Secondary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Uridine Monophosphate; Water	2015
Rate and Equilibrium Constants for an Enzyme Conformational Change during Catalysis by Orotidine 5'-Monophosphate Decarboxylase. Biochemistry, 2015, Jul-28, Volume: 54, Issue:29 Topics: Amino Acid Substitution; Biocatalysis; Catalytic Domain; Kinetics; Orotidine-5'-Phosphate Decarboxylase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity; Uridine Monophosphate	2015
QM/MM reveals the sequence of substrate binding during OPRT action. Computational biology and chemistry, 2018, Volume: 74 Topics: Binding Sites; Magnesium; Molecular Structure; Orotate Phosphoribosyltransferase; Phosphoribosyl Pyrophosphate; Quantum Theory; Saccharomyces cerevisiae; Substrate Specificity; Uridine Monophosphate	2018
Re-refinement of Plasmodium falciparum orotidine 5'-monophosphate decarboxylase provides a clearer picture of an important malarial drug target. Acta crystallographica. Section F, Structural biology communications, 2018, Oct-01, Volume: 74, Issue:Pt 10 Topics: Antimalarials; Binding Sites; Ligands; Models, Molecular; Orotidine-5'-Phosphate Decarboxylase; Plasmodium falciparum; Protein Binding; Protein Conformation, alpha-Helical; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Protozoan Proteins; Substrate Specificity; Uridine Monophosphate	2018
The Role of the Substrate Phosphodianion in Catalysis by Orotidine 5'-Monophosphate Decarboxylase. Biochemistry, 2023, 03-07, Volume: 62, Issue:5 Topics: Carboxy-Lyases; Catalysis; Orotidine-5'-Phosphate Decarboxylase; Uridine Monophosphate	2023