orotic acid and uracil
orotic acid has been researched along with uracil in 232 studies
Research
Studies (232)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 178 (76.72) | 18.7374 |
| 1990's | 20 (8.62) | 18.2507 |
| 2000's | 21 (9.05) | 29.6817 |
| 2010's | 13 (5.60) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Crandall, DE; Tremblay, GC | 1 |
| de Bree, PK; Grift, J; Stoop, JW; van Gennip, AH; Wadman, SK; Zegers, BJ | 1 |
| Donohoe, J; Kolos, G; Lykke, A; Williams, JF | 1 |
| Neuhard, J; Schwartz, M | 1 |
| Bhargava, PM; Bornecque, CA; Szafarz, D; Zajdela, F | 1 |
| Clark, C; Failor, R; Sevilla, MD | 1 |
| Tamemasa, O; Tezuka, M | 1 |
| Ferris, JP; Joshi, PC | 1 |
| Christopherson, RI; Finch, LR | 1 |
| O'Donovan, GA; Womack, JE | 1 |
| Ahmed, AA; McCarthy, RD; Porter, GA | 1 |
| Castle, T; Kreamer, W; Liu, DS; Richardson, A | 1 |
| Fujisawa, M; Takeda, T; Tamemasa, O; Tezuka, M | 1 |
| Al-Baldowi, NF; Brown, EG | 1 |
| Seifert, J; Vácha, J | 1 |
| Koch, MR; Lea, MA; Morris, HP | 1 |
| Anderson, J; Nievel, JG; Robinson, N | 1 |
| Anderson, J; Nievel, JG; Skrbic, TR | 1 |
| Foltermann, KF; Kelln, RA; Kinahan, JJ; O'Donovan, GA | 1 |
| Bakanova, NV; Leutskií, KM | 1 |
| Bhargava, PM; Kumar, GK | 1 |
| Guganig, ME; Reyes, P | 1 |
| Bennett, JE; Edman, JC; Kwon-Chung, KJ; Varma, A | 1 |
| Jensen, KF; Pedersen, S; Vogel, U | 1 |
| Katoh, T; Kidouchi, K; Kobayashi, M; Nakamura, C; Ohba, S; Wada, Y | 1 |
| Katoh, T; Kibe, T; Kidouchi, K; Kobayashi, M; Ohba, S; Wada, Y | 1 |
| Fujimura, H | 1 |
| Kondo, S; Oshima, T; Yamagishi, A | 1 |
| Engelbrecht, C; Yngner, T | 1 |
| Aronsen, KF; Christensson, PI; Lewan, L; Ljungberg, J; Stenram, U; Teder, H | 1 |
| Kondo, T; Murali Krishna, C; Riesz, P | 1 |
| Cowling, RA; Lee, MH; Pettigrew, DW; Sander, EG | 1 |
| Basappa, SC; Murthy, VS; Vishwanath, P | 1 |
| Mill, GC | 1 |
| Bochner, BR; Turnbough, CL | 1 |
| Boctor, A; Grossman, A | 1 |
| Christophe, J; Vandermeers-Piret, MC | 1 |
| Christophe, J; Crokaert, R; Vandermeers-Piret, MC | 1 |
| Zolotnikova, GP | 1 |
| Kummer, D | 1 |
| Chilcote, DD; Mrochek, JE | 1 |
| Gut, J; Santilli, V; Skoda, J; Sorm, F | 1 |
| McMillan, M; Nicolau, C; Norman, RO | 1 |
| Karasek, MA; Pillarisetty, RJ | 1 |
| Dennis, PP; Herman, RK | 2 |
| Doremus, HM; Jaffe, JJ | 1 |
| Plagemann, PG | 1 |
| Cox, GB; Gibson, F; Newton, NA | 1 |
| Neta, P | 2 |
| Guganig, M; Reyes, P | 1 |
| Chudinova, IA; Davidova, SY; Gorozhanskaya, EG; Krechetova, GD; Shapot, VS; Vornovitskaya, GI; Zhubanova, AA | 1 |
| Benson, B; Lorenz, P | 1 |
| Greenstock, CL; Neta, P | 1 |
| Bagnara, AS; Finch, LR | 1 |
| Hüttermann, J; Müller, A | 1 |
| Lindsay, RH; Yu, MW | 1 |
| Chung, SC; Rédei, GP | 1 |
| Bullock, J; Khalil, FL; Lea, MA; Morris, HP | 1 |
| Mandel, HG; Riis, M | 1 |
| Jund, R; Lacroute, F | 1 |
| Cihák, A; Sorm, F | 1 |
| Johns, HE; Whillans, DW | 1 |
| Lascelles, J | 1 |
| Exinger, F; Korch, CT; Lacroute, F | 1 |
| Mizoguchi, M; Okui, K | 1 |
| Itzhaki, S | 1 |
| Ashworth, TS; Brown, EG; Roberts, FM | 1 |
| Belousova, AK; Meĭren, DV | 1 |
| Fanburg, BL; Matsushita, S | 2 |
| Gurpide, E; Tseng, JK | 1 |
| Kamel, MY; Ragaa, RH | 1 |
| Booden, T; Hull, RW | 1 |
| Dewey, VC; Kidder, GW | 1 |
| Tsvetkov, D | 1 |
| Arakawa, T; Wada, Y | 1 |
| Behki, RM; Lesley, SM | 1 |
| Apel, D; Methfessel, J; Schmidt, R; Schultka, R | 1 |
| Heidelberger, C | 1 |
| Wada, Y | 1 |
| Lascelles, J; McIllmurray, MB | 1 |
| Jones, ME | 1 |
| Camakaris, J; Cotton, RG; Danks, DM | 1 |
| Nicolau, C; Singh, BB | 1 |
| Latimer, RG; Mandel, HG; Riis, M | 1 |
| Handschumacher, RE; Markoff, LJ | 1 |
| Barr, CF; Polet, H | 1 |
| Holloway, BW; Isaac, JH | 1 |
| Kaltwasser, H; Krämer, J | 1 |
| Mandel, HG; Szapáry, D; Triester, SR | 1 |
| Decker, K; Domschke, W; Keppler, D; Rudigier, J | 1 |
| Hollander, VP; Mashburn, LT; Stevens, J; Stevens, YW | 1 |
| Calabresi, P; McDonald, CJ | 1 |
| Hough, AJ; Stone, JE | 1 |
| Krooth, RS | 1 |
| Kornacka, L; Malec, J; Wojnarowska, M | 1 |
| Charlier, M; Helene, C | 1 |
| Belser, WL; Hayward, WS | 1 |
| Buchowicz, J; Grzelczak, Z | 1 |
| Becroft, DM; Phillips, LI; Simmonds, A | 1 |
| Aonuma, S; Hama, T; Okumura, H; Tamaki, N | 1 |
| Heath, RL | 1 |
| Kodaira, K; Naora, H | 1 |
| Rochovansky, O | 1 |
| Golaszewski, T; Rytel, M; Szarkowski, JW | 1 |
| Ito, K; Uchino, H | 1 |
| Hori, M; Kunimoto, T; Sawa, T; Umezawa, H; Wakashiro, T | 1 |
| Shaposhinkov, VN; Shvachkin, IuP; Vitol, MIa | 1 |
| Greenstock, CL; Johns, HE | 1 |
| Matolcsy, G; Pozsár, BI | 1 |
| Kosmachevskaia, EA | 1 |
| Lindsay, RH; Romine, CJ; Wong, MY | 1 |
| Drews, J | 1 |
| Johns, HE | 1 |
| Agosin, M; Litvak, S; Poblete, P; Tarragó-Litvak, L | 1 |
| Dyr, J; Skoda, J; Skodová, H; Solínová, H | 1 |
| Busch, H; Muramatsu, M | 1 |
| Hager, SE; Jones, ME | 1 |
| La Torre, JL; Tandler, CJ | 1 |
| Adams, DH | 1 |
| Ishihara, H; Wang, SY | 1 |
| Ito, K; Tatibana, M | 1 |
| Keil, S; Methfessel, J; Schmidt, R | 1 |
| Sandberg, AA; Weinfeld, H | 1 |
| Arion, VJ; Georgiev, GP; Mantieva, VL | 1 |
| Reifer, I; Wasilewska, LD | 1 |
| Brown, IH; Greenstock, CL; Hunt, JW; Johns, HE | 1 |
| Manchester, KL | 1 |
| Calabresi, P; Conn, HO; Creasey, WA | 1 |
| Cain, DF | 1 |
| Craig, JC; Gruenke, L; Jakobs, C; Nyhan, WL; Sweetman, L; Wadman, SK | 1 |
| Galliers, EM; Hansen, JN; Vasantha, N | 1 |
| Cederbaum, SD; Naylor, EW | 1 |
| Bilich, GL; Nazarova, LV; Sungurova, EV | 1 |
| Leshchinskiĭ, LA; Zabel'ian, OM | 1 |
| Malinovsky, NN; Vinnitsky, LI; Zhidkov, IL | 1 |
| McIvor, RS; Plagemann, PG; Wohlhueter, RM | 1 |
| De Abreu, RA; Gabreëls, FJ; Gerrits, GP; Monnens, LA; Niezen-Koning, KE; Trijbels, JM; van Raaij-Selten, B | 1 |
| Bhatia, MB; Grubmeyer, C | 1 |
| Allshire, RC; Cranston, G; Nimmo, ER | 1 |
| Akileswaran, L; Alic, M; Clark, EK; Gold, MH; Hornick, JL | 1 |
| Kidouchi, K; Ohba, S; Sumi, S; Wada, Y | 1 |
| Jones, ME; Traut, TW | 1 |
| Hariguchi, F; Hayashi, T; Kobayashi, N; Matsuno, T; Okada, Y; Okamoto, T | 2 |
| Clifford, AJ; Ho, YK | 1 |
| Duley, JA; Nethersell, AB | 1 |
| Angelot, JM; Asch, DK; Cannon, RC; Marshall, EM; Smiley, JA | 1 |
| Hisatomi, T; Kuroyanagi, S; Tsuboi, M | 1 |
| Celli, M; Crifò, C; D'Eufemia, P; Finocchiaro, R; Giardini, O; Salerno, C | 1 |
| Kim, BG; Kwon, ST; Magae, Y; Yoo, YB | 1 |
| Martusewitsch, E; Schleper, C; Sensen, CW | 1 |
| Kidouchi, K; Kitou, O; Kubota, M; Matsuda, I; Matsuura, T; Mikami, H; Ohura, T; Sumi, S; Togari, H; Wada, Y | 1 |
| Asai, M; Imaeda, H; Kidouchi, K; Sumi, S; Togari, H; Wada, Y | 1 |
| Fletcher, JM; Harbord, MG; Harrison, RJ; Poplawski, NK; Wiltshire, EJ | 1 |
| Ban, K; Fujimoto, S; Hamajima, N; Ito, T; Kidouchi, K; Sumi, S; Togari, H; Ueta, A; Wada, Y | 1 |
| Barshop, BA; Climent, C; Nyhan, WL; Rubio, V | 1 |
| HOLMES, WL; PRUSOFF, WH; WELCH, AD | 1 |
| PRUSOFF, WH | 1 |
| BROOKE, MS; MAGASANIK, B; USHIBA, D | 1 |
| HOLMES, WL; WELCH, AD | 1 |
| HOLMES, WL | 1 |
| CHAUDHURI, NK; DANNEBERG, P; DUSCHINSKY, R; GRIESBACH, L; HEIDELBERGER, C; MOOREN, D; PLEVEN, E; SCHEINER, J; SCHNITZER, RJ | 1 |
| CRAWFORD, I; KORNBERG, A; SIMMS, ES | 1 |
| PARDEE, AB; YATES, RA | 1 |
| PLAUT, W; RUSTAD, RC | 1 |
| HABERMANN, V | 1 |
| MALOOF, F; SOODAK, M | 1 |
| ANDRUS, SB; FILLIOS, LC; NAITO, C; ROACH, AM | 1 |
| GAJDOS, A; GAJDOS-TOEROEK, M | 2 |
| AOKI, A; IBUKI, F; MATSUSHITA, S | 1 |
| BRESNICK, E | 1 |
| AUSCHER, C; DELBARRE, F | 1 |
| BROWN, GM; GOLDSTEIN, GA | 1 |
| Lombardi, B; Sidransky, H; Verney, E | 1 |
| AMSTEY, M; BROWN, O; MCCARTY, KS; WOODSON, B | 1 |
| TARR, HL | 1 |
| MANDEL, HG; TOMCHICK, R | 1 |
| NOVELLI, GD; TAYLOR, WH | 1 |
| COHEN, PP; LINDSAY, RH; NAKAGAWA, H | 2 |
| AKAMATSU, N; COHEN, PP; LINDSAY, RH | 1 |
| ROSS, CW | 1 |
| EVSTIGNEEVA, RP; MIRONOV, AF; MISHINA, NM; PONOMAREV, IV; PREOBRAZHENSKII, NA; SAVENKOVA, KI | 1 |
| BIGGS, H; DOUMAS, B | 1 |
| Andrews, AW; Baugh, CL; Surgalla, MJ | 1 |
| HATFIELD, D; WYNGAARDEN, JB | 1 |
| MANDEL, P; MICHAELIDIS, P | 1 |
| BHARGAVA, PM; JACOB, ST | 2 |
| KORNACKA, L; MALEC, J; WOJNAROWSKA, M; ZAKRZEWSKI, K | 1 |
| ADAMS, HR; BUSCH, H | 1 |
| HANDSCHUMACHER, RE | 1 |
| MCDANIEL, EG; SPAETH, A; WINDMUELLER, HG | 1 |
| COHEN, PP; LINDSAY, RH | 1 |
| LEPAGE, GA; SATO, K | 1 |
| JAFFE, JJ; MOMPARLER, RL | 1 |
| COHEN, PP; KIM, S | 1 |
| KULHANEK, M; SVATEK, E; TADRA, M | 1 |
| LEONARDI, A; PALMA, V | 1 |
| West, TP | 1 |
| Matsumoto, I; Sawamura, M; Suzuki, T; Washizu, M; Washizu, T; Zhang, C | 1 |
| Loukanina, N; Stasolla, C; Thorpe, TA; Yeung, EC | 1 |
| Ban, K; Imaeda, M; Ito, T; Ohkubo, Y; Sumi, S; Togari, H; Ueta, A | 1 |
| Ashihara, H; Loukanina, N; Stasolla, C; Thorpe, TA; Yeung, EC | 1 |
| Conde, RD; Nercessian, D | 1 |
| Mansfield, TA; Mourad, GS; Prabhakar, JT; Schultes, NP; Snook, BM | 1 |
| Alhazzazi, T; Capone, RF; Fenno, JC; Ning, Y; Pakulis, N | 1 |
| Hirai, H; Kimura, T; Oita, S; Sugiura, T; Yamagishi, K | 1 |
| Cregg, JM; Tolstorukov, I | 1 |
| Georgianna, DR; He, ZM; Obrian, GR; Payne, GA; Price, MS | 1 |
| Armstrong, J; Bone, N; Carr, AM; Garcia, V; Watson, AT | 1 |
| Acar, M; Mettetal, JT; van Oudenaarden, A | 1 |
| Bartkowiak, G | 1 |
| Lewis, CA; Wolfenden, R | 1 |
| Matsuda, Y; Nakajima, K; Sakaguchi, T | 1 |
| Robertson, DS | 1 |
| Han, J; Liu, H; Liu, X; Xiang, H; Zhou, J | 1 |
| Ashihara, H; Elhiti, M; Stasolla, C | 1 |
| Chen, M; Thelen, JJ | 1 |
| Murakami, A; Suzuki, H; Yoshida, K | 1 |
| Fairlamb, AH; Ong, HB; Patterson, S; Sienkiewicz, N; Wyllie, S | 1 |
| Auray-Blais, C; Lavoie, P; Maranda, B | 1 |
| Cheng, Z; Guo, Q; Jin, S; Jin, Y; Li, J; Lin, J; Liu, C; Liu, X; Pan, X; Qian, L; Shi, J; Wei, Y; Wu, W; Xia, B; Zhu, F | 1 |
| Ishiwada, N; Kamei, K; Kawamoto, S; Ohkusu, M; Shimizu, K; Takahashi-Nakaguchi, A; Toh-E, A; Watanabe, A | 1 |
| Alissandratos, A; Easton, CJ; Loan, TD | 1 |
| Bruni, GO; Lee, SC; Wang, P; Zhong, K | 1 |
Reviews
8 review(s) available for orotic acid and uracil
| Article | Year |
|---|---|
Notes on some peculiarities of enzymic processes in malignant tumours and tissues of the host.
Topics: Adenine; Animals; Carbon Isotopes; Carcinoma, Hepatocellular; Catalase; Cholesterol; DNA, Neoplasm; Humans; Isoenzymes; L-Lactate Dehydrogenase; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Liver; Liver Neoplasms; Lymphocytes; Neoplasms; Neoplasms, Experimental; Orotic Acid; Pyrimidine Nucleotides; Rats; RNA, Neoplasm; Uracil | 1972 |
Photochemistry and the triplet state of nucleic acids.
Topics: Acetone; Acetophenones; Adenosine Monophosphate; Benzophenones; Cysteine; Cytosine; DNA; Energy Transfer; Freezing; Lasers; Luminescent Measurements; Orotic Acid; Photolysis; Radiation Effects; Radiation-Sensitizing Agents; RNA; Solutions; Temperature; Thymine; Ultraviolet Rays; Uracil; Water | 1973 |
[Inborn errors of purine and pyrimidine metabolism].
Topics: Gout; Humans; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Transferases; Uracil; Xanthines | 1967 |
Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges--G. H. A. Clowes Memorial Lecture.
Topics: Animals; Antineoplastic Agents; Arginase; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Deoxyribonucleases; DNA; Fluorouracil; Humans; Liver Neoplasms; Methylcholanthrene; Mice; Mutation; Neoplasms; Neoplasms, Experimental; Nucleosides; Oncogenic Viruses; Orotic Acid; Phenanthrenes; Protein Binding; Pyrimidinones; Rats; Skin Neoplasms; Thymine; Uracil | 1970 |
[Treatment of congenital purine-pyrimidine metabolism anomalies].
Topics: Athetosis; Chorea; Compulsive Behavior; Gout; Humans; Intellectual Disability; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Pyrimidines; Self Mutilation; Transferases; Uracil; Uric Acid | 1971 |
Regulation of pyrimidine and arginine biosynthesis in mammals.
Topics: Amidohydrolases; Animals; Arginine; Aspartic Acid; Bacillus; Basidiomycota; Carbamates; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Centrifugation, Density Gradient; Enzyme Induction; Enzyme Repression; Escherichia coli; Feedback; Humans; Ligases; Lyases; Mice; Neurospora; Nucleotides; Ornithine Carbamoyltransferase; Orotic Acid; Oxidoreductases; Pentosyltransferases; Phosphotransferases; Pseudomonas; Pyrimidines; Saccharomyces; Transferases; Uracil; Urea | 1970 |
Short-lived free radicals in aqueous solutions of biomolecules.
Topics: Amino Acids; Bromouracil; Caffeine; Chemistry, Organic; Cytosine; Disulfides; Electrons; Free Radicals; Hydrogen Peroxide; Nucleic Acids; Nucleosides; Nucleotides; Organic Chemistry Phenomena; Orotic Acid; Peptides; Proteins; Purines; Pyrimidines; Sulfhydryl Compounds; Thymine; Uracil | 1971 |
Uracil metabolism--UMP synthesis from orotic acid or uridine and conversion of uracil to beta-alanine: enzymes and cDNAs.
Topics: Allosteric Regulation; Amino Acid Sequence; Animals; beta-Alanine; Biological Evolution; DNA, Complementary; Humans; Molecular Sequence Data; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Peptide Synthases; Uracil; Uridine; Uridine Kinase; Uridine Monophosphate | 1996 |
Trials
2 trial(s) available for orotic acid and uracil
| Article | Year |
|---|---|
[Comparative evaluation of the effectiveness of 2 drug combinations (strophanthin and potassium orotate, strophanthin and methyluracil) in circulatory insufficiency].
Topics: Adult; Aged; Cardiovascular Diseases; Chronic Disease; Clinical Trials as Topic; Drug Evaluation; Drug Therapy, Combination; Female; Hemodynamics; Humans; Male; Middle Aged; Natriuresis; Orotic Acid; Potassium; Strophanthins; Uracil | 1980 |
Investigation for the characteristic anticoccidial activity of diclazuril in battery trials.
Topics: Animals; Chickens; Coccidiosis; Coccidiostats; Drug Interactions; Drug Resistance; Eimeria; Nitriles; Nucleic Acid Precursors; Orotic Acid; Poultry Diseases; Triazines; Uracil; Uridine; Uridine Diphosphate Glucose; Uridine Diphosphate N-Acetylglucosamine | 1996 |
Other Studies
222 other study(ies) available for orotic acid and uracil
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Pyrimidine biosynthesis and its regulation in embryos of the sea urchin, Arbacia punctulata.
Topics: Animals; Aspartate Carbamoyltransferase; Aspartic Acid; Azauridine; Bicarbonates; Carbamates; Carbamoyl-Phosphate Synthase (Ammonia); Dihydroorotase; Dihydroorotate Oxidase; Embryo, Nonmammalian; Female; Kinetics; Male; Orotate Phosphoribosyltransferase; Orotic Acid; Pyrimidines; Sea Urchins; Species Specificity; Uracil | 1976 |
Urinary excretion of orotic acid, orotidine and other pyrimidines in a patient with purine nucleoside phosphorylase deficiency.
Topics: Allopurinol; Child; Child, Preschool; Chromatography, High Pressure Liquid; Deoxycytidine; Humans; Infant; Ornithine Carbamoyltransferase Deficiency Disease; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pentosyltransferases; Purine-Nucleoside Phosphorylase; Purine-Pyrimidine Metabolism, Inborn Errors; Respiratory Tract Infections; Uracil; Uridine | 1979 |
Studies using orotic acid for improving the controlled development of myocardial hypertrophy.
Topics: Animals; Cardiomegaly; Energy Metabolism; Glycogen; Leucine; Male; Myocardial Contraction; Myocardium; Orotic Acid; Protein Biosynthesis; Rats; Uracil; Uridine | 1976 |
Control of expression of the pyr genes in Salmonella typhimurium: effects of variations in uridine and cytidine nucleotide pools.
Topics: Amidohydrolases; Arginine; Aspartate Carbamoyltransferase; Carboxy-Lyases; Cell-Free System; Chromosome Mapping; Cysteine; Cytidine; Cytosine Nucleotides; Enzyme Repression; Genes; Genetic Linkage; Mutation; Orotic Acid; Oxidoreductases; Pentosyltransferases; Phosphotransferases; Pyrimidine Nucleotides; Salmonella typhimurium; Transduction, Genetic; Uracil; Uracil Nucleotides | 1975 |
Uptake in vitro of nucleic acid precursors and nucleic acids by Zajdela ascitic hepatoma cells.
Topics: Adenine; Animals; Biological Transport, Active; Carcinoma, Hepatocellular; Cell Line; DNA; DNA, Bacterial; Liver; Liver Neoplasms; Orotic Acid; Rats; Ribonucleosides; RNA; RNA, Bacterial; Uracil; Uridine | 1975 |
ESR study of the anion radicals of 5-nitropyrimidines: conversion to iminoxy radicals.
Topics: Barbiturates; Cyclic N-Oxides; Electron Spin Resonance Spectroscopy; Free Radicals; Nitro Compounds; Orotic Acid; Pyrimidines; Uracil | 1976 |
Incorporation characteristics of uracil, uridine, and orotic acid into ribonucleic acid of neoplastic cells.
Topics: Adult; Aged; Animals; Carcinoma, Ehrlich Tumor; Carcinoma, Hepatocellular; Female; Humans; Liver; Liver Neoplasms; Male; Mice; Middle Aged; Orotic Acid; RNA, Neoplasm; Sarcoma, Experimental; Stomach Neoplasms; Uracil; Uridine; Uridine Kinase; Uridine Phosphorylase | 1977 |
Chemical evolution from hydrogen cyanide: photochemical decarboxylation of orotic acid and orotate derivatives.
Topics: Decarboxylation; Hydrogen Cyanide; Orotic Acid; Photochemistry; Ribonucleotides; Uracil; Uridine; Uridine Monophosphate | 1978 |
Response of the pyrimidine pathway of Escherichia coli K 12 to exogenous adenine and uracil.
Topics: Adenine; Aspartate Carbamoyltransferase; Aspartic Acid; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); Carbamyl Phosphate; Escherichia coli; Kinetics; Orotate Phosphoribosyltransferase; Orotic Acid; Pyrimidines; Uracil | 1978 |
Orotic acid excretion in some wild-type strains of Escherichia coli K-12.
Topics: Escherichia coli; Genes; Mutation; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Uracil | 1978 |
Effect of milk constituents on hepatic cholesterol-genesis.
Topics: Acetates; Animals; Cattle; Cholesterol; Humans; Liver; Male; Mevalonic Acid; Milk; Orotic Acid; Rats; Uracil | 1979 |
Characterization of RNA synthesis by isolated hepatocytes in suspension.
Topics: Animals; Cell Nucleus; Dactinomycin; Female; In Vitro Techniques; Kinetics; Liver; Orotic Acid; Poly A; Rats; RNA; Transcription, Genetic; Uracil; Uridine | 1979 |
Elevation of the salvage synthesis of ribonucleic acid in the rat liver during the induction of hepatoma with 3'-methyl-4-(dimethylamino)azobenzene.
Topics: Animals; Cells, Cultured; Culture Techniques; Liver; Liver Neoplasms, Experimental; Male; Methyldimethylaminoazobenzene; Orotic Acid; Pentosyltransferases; Rats; RNA; Uracil; Uridine Kinase; Uridine Phosphorylase | 1978 |
Biosynthesis of the pyrimidinyl amino acid lathyrine by Lathyrus tingitanus L.
Topics: Amino Acids, Diamino; Homoarginine; Orotic Acid; Plants; Pyrimidines; Uracil | 1977 |
Biosynthesis of cytidine nucleotides and level of cytochrome P-450 in rat liver after administration of carbon tetrachloride.
Topics: Animals; Carbon Disulfide; Carbon Tetrachloride Poisoning; Cobalt; Cytochrome P-450 Enzyme System; Cytosine Nucleotides; Liver; Male; Orotic Acid; Rats; Uracil | 1977 |
Decreased uptake of orotate in kidney tumors.
Topics: Animals; Kidney Cortex; Kidney Medulla; Kidney Neoplasms; Male; Neoplasms, Experimental; Orotic Acid; Rats; RNA, Neoplasm; Uracil | 1976 |
Changes in nucleotide metabolism of the liver and fate of [14C]orotate among various pyrimidines at the outset and during induction of drug-metabolizing enzymes and hepatomegaly.
Topics: Animals; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; DNA Replication; Enzyme Induction; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Protein Biosynthesis; Rats; Ribonucleotides; Transcription, Genetic; Uracil | 1976 |
Studies on the relationship between induction of drug-metabolizing enzymes, liver enlargement and ascorbic acid excretion in rodents.
Topics: Animals; Ascorbic Acid; Azauridine; Butylated Hydroxytoluene; Coumarins; Dactinomycin; Enzyme Induction; Female; Glucuronates; Hepatomegaly; Liver; Orotic Acid; Phenobarbital; Proadifen; Rats; Transcription, Genetic; Uracil; Uracil Nucleotides | 1976 |
Pyrimidine biosynthetic enzymes of Salmonella typhimurium, repressed specifically by growth in the presence of cytidine.
Topics: Adenine Nucleotides; Amidohydrolases; Arginine; Aspartate Carbamoyltransferase; Carboxy-Lyases; Cell-Free System; Cytidine; Cytosine Nucleotides; Enzyme Repression; Guanine Nucleotides; Ornithine Carbamoyltransferase; Orotic Acid; Oxidoreductases; Pentosyltransferases; Pyrimidines; Salmonella typhimurium; Uracil; Uracil Nucleotides | 1975 |
[The effect of orotic acid and vitamin A on 2C-14-orotic acid incorporation into the acid-soluble fraction and nucleic acids of white rat tissues].
Topics: Adenine; Animals; Brain; Brain Chemistry; Carbon Radioisotopes; DNA; Guanine; Kidney; Liver; Male; Orotic Acid; Rats; RNA; Spleen; Testis; Uracil; Vitamin A | 1975 |
Comparison of some permeability properties of rat liver slices, liver cells in suspension, and in vivo-produced aggregates of dispersed liver cells.
Topics: Animals; Biological Transport, Active; Cell Aggregation; DNA, Bacterial; Female; In Vitro Techniques; Liver; Male; Nucleic Acids; Orotic Acid; Permeability; Rats; Ribonucleases; RNA, Bacterial; Uracil; Uridine | 1975 |
Studies on a pyrimidine phosphoribosyltransferase from murine leukemia P1534J. Partial purification, substrate specificity, and evidence for its existence as a bifunctional complex with orotidine 5-phosphate decarboxylase.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; Carboxylic Acids; Cells, Cultured; Centrifugation, Density Gradient; Chromatography, DEAE-Cellulose; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Fluorouracil; Hot Temperature; Kinetics; Leukemia, Experimental; Mice; Orotic Acid; Pentosyltransferases; Peptide Hydrolases; Phosphoribosyl Pyrophosphate; Pyrimidines; Uracil; Uracil Nucleotides; Uridine Phosphorylase | 1975 |
Selection of ura5 and ura3 mutants from the two varieties of Cryptococcus neoformans on 5-fluoroorotic acid medium.
Topics: Animals; Blotting, Southern; Cryptococcus neoformans; Culture Media; Deoxyribonuclease EcoRI; Deoxyribonucleases, Type II Site-Specific; DNA, Fungal; Humans; Mutation; Nucleic Acid Hybridization; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Restriction Mapping; Transformation, Genetic; Uracil; Uridine | 1992 |
An unusual correlation between ppGpp pool size and rate of ribosome synthesis during partial pyrimidine starvation of Escherichia coli.
Topics: Escherichia coli; Guanosine Tetraphosphate; Orotic Acid; Pyrimidines; Ribosomal Proteins; Ribosomes; RNA, Bacterial; RNA, Ribosomal; Uracil; Uridine Triphosphate | 1991 |
Reference values of orotic acid, uracil and pseudouridine in urine.
Topics: Adolescent; Adult; Amino Acid Metabolism, Inborn Errors; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Infant; Infant, Newborn; Male; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Pseudouridine; Reference Values; Uracil | 1991 |
Automated determination of orotic acid, uracil and pseudouridine in urine by high-performance liquid chromatography with column switching.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, High Pressure Liquid; Female; Humans; Infant; Metabolism, Inborn Errors; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Pseudouridine; Spectrophotometry, Ultraviolet; Uracil | 1991 |
Transformation of the yeast Saccharomyces kluyveri by Saccharomyces cerevisiae-based plasmids.
Topics: Ampicillin; Ampicillin Resistance; Centromere; Electrophoresis, Agar Gel; Ethyl Methanesulfonate; Mutation; Orotic Acid; Plasmids; Saccharomyces; Saccharomyces cerevisiae; Transformation, Genetic; Uracil | 1991 |
Positive selection for uracil auxotrophs of the sulfur-dependent thermophilic archaebacterium Sulfolobus acidocaldarius by use of 5-fluoroorotic acid.
Topics: Culture Media; Genotype; Mutation; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Species Specificity; Sulfolobus acidocaldarius; Uracil | 1991 |
Metabolism of uridine and determination of liver ribonucleic acid synthesis in developing and adult mice.
Topics: Aging; Alanine; Animals; beta-Alanine; Liver; Male; Mice; Orotic Acid; RNA; Tritium; Uracil; Uridine; Uridine Monophosphate; Uridine Triphosphate | 1985 |
Hepatic artery administration of degradable starch microspheres. I. Effect on energy charge and incorporation of precursors into rat liver nucleic acids.
Topics: Animals; Carbon Radioisotopes; DNA; Hepatic Artery; Injections, Intra-Arterial; Kinetics; Liver; Male; Microspheres; Orotic Acid; Rats; Rats, Inbred Strains; RNA; Starch; Thymidine; Tritium; Uracil | 1985 |
Sonolysis, radiolysis, and hydrogen peroxide photolysis of pyrimidine derivatives in aqueous solutions: a spin-trapping study.
Topics: Benzenesulfonates; Electron Spin Resonance Spectroscopy; Free Radicals; Hydrogen Peroxide; Nitroso Compounds; Orotic Acid; Photolysis; Pyrimidines; Radiation Effects; Solutions; Spin Labels; Thymine; Ultrasonics; Uracil; Water | 1988 |
Bovine liver dihydropyrimidine amidohydrolase: pH dependencies of inactivation by chelators and steady-state kinetic properties.
Topics: Amidohydrolases; Animals; Binding, Competitive; Cattle; Chelating Agents; Hydrogen-Ion Concentration; Kinetics; Liver; Orotic Acid; Oxyquinoline; Phenanthrolines; Picolinic Acids; Uracil | 1986 |
Mechanism of counteraction of aflatoxin toxicity by thymine and folic acid in Bacillus megaterium.
Topics: Aflatoxin B1; Aflatoxins; Aminopterin; Aspartic Acid; Bacillus megaterium; DNA, Bacterial; Drug Synergism; Folic Acid; Orotic Acid; Thymine; Uracil; Uridine Monophosphate | 1986 |
Urinary purines, pyrimidines and nucleosides in uridine-treated orotic aciduria.
Topics: Adolescent; Adult; Child; Chromatography, Ion Exchange; Humans; Male; Nucleosides; Orotic Acid; Purines; Pyrimidines; Uracil; Uridine | 1988 |
Toxicity of the pyrimidine biosynthetic pathway intermediate carbamyl aspartate in Salmonella typhimurium.
Topics: Aspartic Acid; Genotype; Kinetics; Orotic Acid; Pyrimidines; Salmonella typhimurium; Species Specificity; Uracil | 1985 |
[Molecular origin of the effects of light on nucleic acid metabolism].
Topics: Animals; Bacteria; Bacteriophages; Cytosine; DNA; Humans; Methylene Blue; Mice; Nucleic Acid Renaturation; Nucleic Acids; Orotic Acid; Photochemistry; Protein Conformation; Pyrimidines; Quaternary Ammonium Compounds; Radiation Effects; RNA; Skin Neoplasms; Thioxanthenes; Thymine; Ultraviolet Rays; Uracil; Viruses | 1974 |
Differential sensitivity of rat liver and rat hepatoma cells to alpha-amanitin.
Topics: Adrenalectomy; Animals; Basidiomycota; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Nucleus; Dactinomycin; DNA-Directed RNA Polymerases; Enzyme Induction; Hydrocortisone; Liver; Liver Neoplasms; Mycotoxins; Nucleotides; Oligopeptides; Orotic Acid; Peptides, Cyclic; Rats; Tritium; Tyrosine Transaminase; Uracil; Uridine | 1973 |
[Effects of lysine deficiency on the rat liver].
Topics: Animals; Carbon Isotopes; Deficiency Diseases; In Vitro Techniques; Leucine; Liver; Lysine; Orotic Acid; Protein Biosynthesis; Rats; RNA; Thymidine; Uracil | 1964 |
[Catabolism of uracil in Torulopsis utilis].
Topics: Barbiturates; Chromatography; In Vitro Techniques; Mitosporic Fungi; Orotic Acid; Propionates; Uracil; Urea | 1964 |
[The effect of stimulants of non-specific proteosynthesis on the antibody synthesizing activity of explants of the liver and spleen of immunized and irradiated rabbits].
Topics: Adenosine Triphosphate; Animals; Antibody Formation; Choline; gamma-Globulins; Glucose; Immunization; Liver; Orotic Acid; Rabbits; Radiation Effects; Spleen; Uracil; Vaccination; Vibrio Infections | 1969 |
[Effects of cytostatics and x-rays on nucleic acid metabolism of solid, malignant tumors in vitro].
Topics: Adenine; Animals; Antineoplastic Agents; Carbon Isotopes; Dactinomycin; Depression, Chemical; DNA, Neoplasm; Estriol; Fluorouracil; Formates; Glycine; Hypoxanthines; In Vitro Techniques; Leucine; Mercaptopurine; Methotrexate; Methylprednisolone; Neoplasm Proteins; Neoplasms, Experimental; Nucleosides; Orotic Acid; Radiation Effects; RNA, Neoplasm; Testosterone; Thymidine; Triaziquone; Uracil; Uridine | 1970 |
Use of automatic digital data acquisition and on-line computer analysis in high-resolution liquid chromatography.
Topics: Autoanalysis; Chromatography; Computers; Cyclic N-Oxides; Hippurates; Hypoxanthines; Mathematics; Methods; Niacinamide; Nicotinic Acids; Orotic Acid; Pyrimidines; Ribonucleosides; Spectrophotometry; Theophylline; Ultraviolet Rays; Uracil; Uric Acid; Xanthines | 1971 |
Dihydro-5-azaorotic acid, the first specific inhibitor of dihydro-orotate dehydrogenase.
Topics: Acids; Animals; Carbon Isotopes; Carboxy-Lyases; Diphosphates; Glucosyltransferases; In Vitro Techniques; Liver; Mice; NAD; Nucleosides; Nucleotides; Orotic Acid; Oxidoreductases; Succinates; Triazines; Uracil; Urea | 1968 |
An ESR study of short-lived radicals derived from pyrimidines in aqueous solution.
Topics: Chemical Phenomena; Chemistry; Computers; Cytosine; Electron Spin Resonance Spectroscopy; Free Radicals; Orotic Acid; Pyrimidines; Solutions; Thymine; Time Factors; Uracil; Water | 1969 |
Pyrimidine biosynthesis de novo in skin.
Topics: Animals; Animals, Newborn; Aspartic Acid; Bicarbonates; Carbamates; Carbon Isotopes; Chromatography, Ion Exchange; Chromatography, Paper; Chromatography, Thin Layer; Cytosine Nucleotides; Depression, Chemical; Hydrogen-Ion Concentration; In Vitro Techniques; Methods; Orotic Acid; Perchlorates; RNA; Skin; Solubility; Uracil; Uracil Nucleotides | 1970 |
Control of deoxyribonucleic acid and ribonucleic acid synthesis in pyrimidine-limited Escherichia coli.
Topics: Autoradiography; Chromatography; Chromosomes, Bacterial; DNA Replication; DNA, Bacterial; Electrophoresis; Escherichia coli; Orotic Acid; Pyrimidines; Ribosomes; RNA, Bacterial; RNA, Transfer; Silicon Dioxide; Spectrophotometry; Thymine; Tritium; Uracil | 1970 |
Metabolic patterns of Dirofilaria immitis microfilariae in vitro.
Topics: Adenine; Amino Acids; Animals; Benzenesulfonates; Carbon Dioxide; Carbon Isotopes; Diethylcarbamazine; Dithiazanine; DNA; Filarioidea; Formates; Glucose; Glycine; Glycogen; In Vitro Techniques; Lipid Metabolism; Orotic Acid; Proteins; RNA; Uracil; Uridine | 1970 |
Nucleotide pools of Novikoff rat hepatoma cells growing in suspension culture. I. Kinetics of incorporation of nucleosides into nucleotide pools and pool sizes during growth cycle.
Topics: Animals; Aspartic Acid; Biological Transport; Carbon Isotopes; Carcinoma, Hepatocellular; Cell Line; Chromatography, Paper; Culture Media; Culture Techniques; Diffusion; DNA; Electrophoresis; Hypoxanthines; Kinetics; Liver Neoplasms; Neoplasms, Experimental; Nucleosides; Nucleotides; Orotic Acid; Rats; RNA; Thymidine; Time Factors; Tritium; Uracil; Uridine | 1971 |
The function of menaquinone (vitamin K 2 ) in Escherichia coli K-12.
Topics: Aerobiosis; Anaerobiosis; Cell Membrane; Chromosome Mapping; Escherichia coli; Fluorometry; Fumarates; Genetics, Microbial; Glucose; Kinetics; Lactates; Mutation; NAD; Orotic Acid; Oxidoreductases; Oxygen Consumption; Transduction, Genetic; Ubiquinone; Uracil; Vitamin K | 1971 |
Electron spin resonance study of radicals produced in irradiated aqueous solutions of uracil and related pyrimidines.
Topics: Barbiturates; Chemical Phenomena; Chemistry; Electron Spin Resonance Spectroscopy; Electrons; Formates; Free Radicals; Hydrogen-Ion Concentration; Nitrous Oxide; Orotic Acid; Pyrimidines; Radiation Effects; Solutions; Spectrum Analysis; Thymine; Uracil; Water | 1972 |
A new and highly sensitive radiotracer assay for orotate phosphoribosyltransferase.
Topics: Animals; Carbon Isotopes; Cell Line; Chromatography, Thin Layer; Enzyme Activation; Fluorouracil; Hydrogen-Ion Concentration; Kinetics; Leukemia, Experimental; Magnesium; Methods; Mice; Microchemistry; Orotic Acid; Pentosephosphates; Pentosyltransferases; Phosphoric Acids; Ribose; Uracil | 1972 |
Free radicals in irradiated nitro-substituted pyrimidines.
Topics: Barbiturates; Electron Spin Resonance Spectroscopy; Free Radicals; Nitro Compounds; Orotic Acid; Pyrimidines; Radiation Effects; Temperature; Uracil | 1973 |
Electron spin resonance and pulse radiolysis studies of irradiated aqueous solutions of 5-nitrouracils. Oxidative denitration by OH radicals.
Topics: Barbiturates; Electron Spin Resonance Spectroscopy; Free Radicals; Nitro Compounds; Orotic Acid; Radiation Effects; Radiation-Sensitizing Agents; Uracil | 1973 |
Correspondence: On the ESR spectra of radicals produced by the reaction of OH with uracils.
Topics: Electron Spin Resonance Spectroscopy; Free Radicals; Hydroxides; Orotic Acid; Radiochemistry; Uracil | 1973 |
The effects of bases and nucleosides on the intracellular contents of nucleotides and 5-phosphoribosyl 1-pyrophosphate in Escherichia coli.
Topics: Adenine; Adenine Nucleotides; Adenosine; Carbon Radioisotopes; Cytosine Nucleotides; Escherichia coli; Guanine; Guanine Nucleotides; Guanosine; Hypoxanthines; Inosine; Inosine Nucleotides; Kinetics; Organophosphorus Compounds; Orotic Acid; Pentosephosphates; Phosphoric Acids; Ribonucleosides; Ribonucleotides; Time Factors; Uracil; Uracil Nucleotides; Uridine | 1974 |
Structure and formation of free radicals in irradiated single crystals of nucleic acid constituents.
Topics: Adenine; Barbiturates; Bromodeoxyuridine; Crystallization; Electron Spin Resonance Spectroscopy; Free Radicals; Guanine; Idoxuridine; Molecular Conformation; Orotic Acid; Purines; Pyrimidines; Radiation Effects; Structure-Activity Relationship; Thymine; Uracil | 1973 |
Inhibitory effects of 2-thiouracil and 2-thiouracil metabolites on enzymes involved in pyrimidine nucleotide biosynthesis.
Topics: Animals; Carbon Radioisotopes; Carboxy-Lyases; In Vitro Techniques; Kinetics; Mice; Nucleotidyltransferases; Orotic Acid; Pentosyltransferases; Phosphotransferases; Proteins; Pyrimidines; Rats; Thiouracil; Thymidine; Thymine; Uracil; Uracil Nucleotides; Uridine | 1974 |
An anomaly of the genetic regulation of the de novo pyrimidine pathway in the plant Arabidopsis.
Topics: Acid Phosphatase; Alleles; Carbon Radioisotopes; Carboxy-Lyases; Chromatography, Thin Layer; Genes, Recessive; Genes, Regulator; Genotype; Homozygote; Humans; Kinetics; Mesylates; Mutation; Orotic Acid; Pentosyltransferases; Plants; Pyrimidine Nucleotides; Pyrimidines; Radiation Effects; RNA; Species Specificity; Time Factors; Uracil | 1974 |
Incorporation of precursors and inhibitors of nucleic acid synthesis into hepatomas and liver of the rat.
Topics: Amino Acids; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell Line; Fluorouracil; Injections, Intraperitoneal; Injections, Subcutaneous; Liver; Liver Neoplasms; Liver Regeneration; Male; Neoplasm Transplantation; Neoplasms, Experimental; Orotic Acid; Phosphates; Rats; RNA, Neoplasm; Schistosomicides; Thioxanthenes; Thymidine; Time Factors; Transplantation, Homologous; Tritium; Uracil; Uridine | 1974 |
Interference of barbiturates with pyrimidine incorporation. II. Structural specificity of the inhibition of orotate uptake in Bacillus cereus.
Topics: Amobarbital; Bacillus cereus; Barbiturates; Bemegride; Biological Transport; Carbon Isotopes; Carboxylic Acids; Central Nervous System Stimulants; Chemical Phenomena; Chemistry; Chemistry, Physical; Chlorine; Chlorpromazine; Glutethimide; Hexobarbital; Hydantoins; Hydrocarbons, Halogenated; Hydrogen-Ion Concentration; Orotic Acid; Pentobarbital; Phenobarbital; Phenytoin; Primidone; Solubility; Succinimides; Thiopental; Thymine; Trimethadione; Tromethamine; Uracil; Urea | 1970 |
Regulation of orotidylic acid pyrophosphorylase in Saccharomyces cerevisiae.
Topics: Amidohydrolases; Amino Acids; Aspartic Acid; Carbamates; Carboxy-Lyases; Cell-Free System; Culture Media; Enzyme Induction; Enzyme Repression; Fluorouracil; Genes; Genetic Complementation Test; Genetics, Microbial; Mutation; Orotic Acid; Oxidoreductases; Pentosyltransferases; Pyrimidines; Saccharomyces; Saccharomyces cerevisiae; Spectrophotometry; Transferases; Uracil; Uracil Nucleotides | 1972 |
Metabolic transformations of 5-azauracil and 5-azaorotic acid in mouse liver and Escherichia coli. Effect on the synthesis of pyrimidines.
Topics: Aza Compounds; Biotransformation; Carbon Isotopes; Carboxy-Lyases; Cell-Free System; Escherichia coli; Liver; Orotic Acid; Pentosyltransferases; Pyrimidines; RNA; Triazines; Uracil; Uridine | 1972 |
Anaerobic growth requirements of staphylococci and the enzymes of pyrimidine synthesis.
Topics: Acetates; Aerobiosis; Anaerobiosis; Cell-Free System; Escherichia coli; Fumarates; Hemin; L-Lactate Dehydrogenase; Mutation; Nitrate Reductases; Orotic Acid; Oxidoreductases; Pyrimidines; Pyruvates; Staphylococcus; Uracil | 1974 |
A regulatory interaction between pyrimidine and purine biosyntheses via ureidosuccinic acid.
Topics: Adenine; Aspartic Acid; Carbamates; Cytosine; Drug Resistance, Microbial; Mutation; Orotic Acid; Phenotype; Purines; Pyrimidines; Saccharomyces cerevisiae; Uracil | 1974 |
[Pyrimidine derivatives. VI. Studies on the syntheses of orotic acid, uracil and pyrimido(5,4-d)pyrimidine derivatives].
Topics: Mass Spectrometry; Orotic Acid; Pyrimidines; Spectrophotometry, Infrared; Uracil | 1972 |
Regulation of uracil utilization for RNA synthesis in Ehrlich ascites tumour cells by glucose metabolism.
Topics: Animals; Biological Transport; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Dose-Response Relationship, Drug; Glucose; Mice; Orotic Acid; Osmolar Concentration; RNA, Neoplasm; Stimulation, Chemical; Thymidine; Uracil | 1972 |
Biosynthesis of willardiine and isowillardiine in germinating pea seeds and seedlings.
Topics: Alanine; Carbon Isotopes; Chromatography, Ion Exchange; Light; Orotic Acid; Pyrimidinones; Seeds; Structure-Activity Relationship; Thiouracil; Uracil | 1972 |
[Mechanism of action of ftorafur, a new antineoplastic agent].
Topics: Animals; Anti-Infective Agents; Antineoplastic Agents; Carbon Radioisotopes; Carcinoma, Ehrlich Tumor; Deoxyuridine; DNA, Neoplasm; Fluorouracil; Formates; Hot Temperature; In Vitro Techniques; Leukemia, Experimental; Mice; Neoplasm Transplantation; Orotic Acid; Pentosyltransferases; RNA, Neoplasm; Sarcoma 37; Spectrum Analysis; Uracil; Uridine | 1972 |
The effect of calcium on labeling of nucleic acids with radioactive precursors in heart tissue slices.
Topics: Animals; Calcium; Chromatography, Thin Layer; Culture Media; Culture Techniques; Cytidine; Dactinomycin; DNA; Male; Myocardium; Orotic Acid; Perfusion; Pyrimidine Nucleotides; Rats; RNA; Stimulation, Chemical; Thymidine; Time Factors; Tritium; Uracil; Uracil Nucleotides; Uridine | 1973 |
Compartmentalization of uridine and uridine 5'-monophosphate in rat liver slices.
Topics: Animals; Carbon Isotopes; Cell Membrane; Cytoplasm; Female; Kinetics; Liver; Mathematics; Models, Biological; Models, Chemical; Orotic Acid; Perfusion; Rats; Tritium; Uracil; Uracil Nucleotides; Uridine | 1973 |
Constitutive synthesis of urease in Aerobacter aerogenese PRL-R3. The effect of different nitrogenous compounds on its inhibition and formation.
Topics: Allantoin; Alloxan; Ammonium Sulfate; Barbiturates; Cell Membrane Permeability; Enterobacter; Enzyme Induction; Enzyme Repression; Orotic Acid; Uracil; Urea; Urease; Xanthines | 1973 |
Nucleic acid precursor synthesis by Plasmodium lophurae parasitizing chicken erythrocytes.
Topics: Adenine; Animals; Autoradiography; Carbon Radioisotopes; Chickens; Culture Media; DNA; Erythrocytes; Formates; Glycine; Malaria, Avian; Male; Orotic Acid; Plasmodium; Purine Nucleotides; Pyrimidine Nucleotides; RNA; Spectrophotometry; Thymidine; Tritium; Uracil; Uridine | 1973 |
The sites of action of allopurinol in Crithidia fasciculata.
Topics: Adenine; Allopurinol; Animals; Carbon Radioisotopes; Cell-Free System; Chemical Phenomena; Chemistry; Chromatography, Paper; Colorimetry; Cytosine; Dose-Response Relationship, Drug; Eukaryota; Folic Acid; Guanine; Hypoxanthines; Orotic Acid; Pentosyltransferases; Pterins; Spectrophotometry; Uracil; Xanthines | 1973 |
[Effect of high-frequency vibrations on RNA synthesis in parenchymatous organs].
Topics: Animals; Carbon Radioisotopes; Kidney; Liver; Orotic Acid; Rats; RNA; Uracil; Vibration | 1973 |
Mode of action of myxin on Escherichia coli.
Topics: Anti-Bacterial Agents; Bacterial Proteins; Carbon Isotopes; DNA, Bacterial; Escherichia coli; Glucose; Leucine; Orotic Acid; RNA, Bacterial; Thymine; Uracil | 1967 |
[Morphological and biochemical studies of the effect of barbituric acid, ureidosuccinic acid, orotic acid, uracil and thymine on the diabetogenic effect of alloxan].
Topics: Adrenal Glands; Alloxan; Amino Alcohols; Animals; Barbiturates; Blood Glucose; Diabetes Mellitus, Experimental; Female; Histological Techniques; Injections, Intraperitoneal; Kidney; Liver; Orotic Acid; Pancreas; Rats; Succinates; Thymine; Thyroid Gland; Uracil; Uric Acid | 1968 |
Pyrimidine pools and macromolecular composition of pyrimidine-limited Escherichia coli.
Topics: Bacterial Proteins; Carbon Isotopes; Centrifugation; Chromatography, Thin Layer; Culture Media; Cytosine Nucleotides; DNA, Bacterial; Escherichia coli; Orotic Acid; Pyrimidines; RNA, Bacterial; Transferases; Trichloroacetic Acid; Uracil; Uracil Nucleotides | 1970 |
Anaerobiosis and the activity of enzymes of pyrimidine biosynthesis in Staphylococcus aureus.
Topics: Air; Carboxy-Lyases; Cell-Free System; Cytochromes; Escherichia coli; Imines; Orotic Acid; Oxidoreductases; Oxygen; Pyrimidines; Quinones; Staphylococcus; Transferases; Uracil | 1970 |
A screening test for urinary purines and pyrimidines and related compounds using auxotrophic mutants of Escherichia coli K12.
Topics: Adenine; Alanine; Aspartic Acid; Biological Assay; Carbamates; Child; Chromatography, Paper; Cytosine; Escherichia coli; Glycosides; Humans; Imidazoles; Inosine; Mutation; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Purines; Purinones; Pyrimidines; Ribose; Thymine; Uracil; Uric Acid | 1970 |
The actions of thioguanine in Bacillus cereus.
Topics: Bacillus cereus; DNA, Bacterial; Flagella; Glycine; Guanine; In Vitro Techniques; Lysine; Mercaptopurine; Orotic Acid; Penicillinase; Phosphates; RNA, Bacterial; Thioguanine; Uracil | 1965 |
Enzymatic formation of uracil and azauriail nucleotides in Streptococcus faecalis.
Topics: Carbon Isotopes; Carboxy-Lyases; Enterococcus faecalis; Glucosyltransferases; Orotic Acid; Pyrophosphatases; Uracil; Uracil Nucleotides | 1966 |
DNA, RNA , and protein synthesis in erythrocytic forms of Plasmodium knowlesi.
Topics: Adenine; Animals; Antimalarials; Carbon Isotopes; Culture Media; DNA; Erythrocytes; Glycine; Haplorhini; Isoleucine; Methionine; Orotic Acid; Phenylalanine; Plasmodium; Protein Biosynthesis; RNA; Sulfur Isotopes; Thymidine; Tritium; Tryptophan; Uracil; Uridine | 1968 |
Control of pyrimidine biosynthesis in Pseudomonas aeruginosa.
Topics: Amidohydrolases; Carboxy-Lyases; Chromosome Mapping; Chromosomes, Bacterial; Enzyme Repression; Genetics, Microbial; Molecular Biology; Mutation; Orotic Acid; Oxidoreductases; Pseudomonas aeruginosa; Pyrimidines; Transduction, Genetic; Transferases; Uracil | 1968 |
[Utilization of pyrimidine derivatives by Hydrogenomonas facilis. II. Degradation of thymine and uracil by wild type and mutants].
Topics: Aminohydrolases; Bacterial Proteins; Cell-Free System; Culture Media; Cytosine; Fructose; Genetics, Microbial; Hydro-Lyases; Mutation; Nitrogen; Orotic Acid; Oxidoreductases; Penicillins; Pseudomonas; Thymine; Uracil | 1969 |
Interference of barbiturates with pyrimidine incorporation. 3. Studies on the mechanism of the amobarbital-orotate relationship.
Topics: Adenine; Alcohols; Amobarbital; Animals; Arsenic; Azides; Bacillus cereus; Bacillus megaterium; Bacillus subtilis; Biological Transport; Carbon Isotopes; Cell Membrane; Chlorpromazine; Chromatography, Paper; Cyanides; Dinitrophenols; Drug Synergism; Inulin; Kinetics; Mice; Nucleic Acids; Orotic Acid; Oxygen Consumption; Pentobarbital; Potassium; Potassium Isotopes; Pyrimidines; Radioisotopes; Rubidium; Species Specificity; Sucrose; Temperature; Uracil | 1970 |
Cell damage by trapping of biosynthetic intermediates. The role of uracil nucleotides in experimental hepatitis.
Topics: Alanine Transaminase; Animals; Bilirubin; Chemical and Drug Induced Liver Injury; Female; Hepatitis; Hexosamines; Liver; Orotic Acid; Oxidoreductases; Rats; Uracil; Uracil Nucleotides; Uridine | 1971 |
Glucocorticoid inhibition of precursor incorporation into nuclear RNA of P1798 lymphosarcoma.
Topics: Animals; Carbon Isotopes; Cell Biology; Cell Nucleus; Centrifugation, Density Gradient; Chromatography; Depression, Chemical; Fluorine; Hydrogen-Ion Concentration; In Vitro Techniques; Lymphoma, Non-Hodgkin; Mice; Mitochondria; Nucleosides; Nucleotides; Orotic Acid; Prednisolone; Pyrimidines; RNA, Neoplasm; RNA, Ribosomal; Solubility; Time Factors; Tritium; Uracil; Uridine | 1971 |
Azaribine for mycosis fungoides.
Topics: Acetates; Administration, Oral; Adult; Aged; Antimetabolites; Aspartic Acid; Blood Cell Count; Central Nervous System; Chemical Phenomena; Chemistry; Female; Hematocrit; Humans; Kidney; Liver; Male; Middle Aged; Mycosis Fungoides; Orotic Acid; Purpura; Triazines; Uracil | 1971 |
Simple systems for the investigation of the effects of drugs upon uridine nucleotide metabolism.
Topics: Animals; Barbiturates; Brain; Ethylmaleimide; Hydrogen-Ion Concentration; Kinetics; Male; Methods; Nucleoside Diphosphate Sugars; Orotic Acid; Rats; Sulfhydryl Reagents; Uracil; Uracil Nucleotides | 1971 |
Molecular models for pharmacological tolerance and addiction.
Topics: Adipose Tissue; Animals; Barbiturates; Carboxy-Lyases; Cell Line; Drug Tolerance; Enzyme Activation; Genetics, Medical; Heart; Heterozygote; Homozygote; Humans; Kidney; Leukocyte Count; Leukopenia; Liver; Male; Models, Biological; Muscles; Mutation; Myocardium; Nucleotides; Orotic Acid; Rats; Spleen; Substance-Related Disorders; Uracil; Uracil Nucleotides | 1971 |
Nuclear RNA of normal and leukaemic human leucocytes.
Topics: Carbon Isotopes; Cell Nucleolus; Cell Nucleus; Chemistry Techniques, Analytical; Chromatin; Chromatography, Paper; DNA; Glycine; Humans; Leukemia, Lymphoid; Leukemia, Myeloid; Leukocytes; Nucleotides; Orotic Acid; Phosphates; Phosphorus Isotopes; RNA; Uracil | 1971 |
Photosensitized splitting of pyrimidine dimers by indole derivatives.
Topics: 5-Hydroxytryptophan; Carbon Isotopes; Chromatography, Paper; Electron Transport; Fluorescence; Freezing; Orotic Acid; Photochemistry; Radiation Effects; Spectrophotometry; Thymine; Tryptophan; Ultraviolet Rays; Uracil | 1971 |
Regulation of pyrimidine biosynthesis in Serratia marcescens.
Topics: Amidohydrolases; Carboxy-Lyases; Chromosome Mapping; Chromosomes; Glucosyltransferases; In Vitro Techniques; Mutation; Orotic Acid; Oxidoreductases; Pyrimidines; Serratia marcescens; Uracil | 1965 |
Pyrimidine and purine bases and nucleosides in wheat plants.
Topics: Adenine; Carbon Isotopes; Chromatography; Cytosine; Nucleosides; Orotic Acid; Purines; Pyrimidines; Radioisotope Dilution Technique; Triticum; Uracil; Uridine | 1967 |
Hereditary orotic aciduria: long-term therapy with uridine and a trial of uracil.
Topics: Alanine; Anemia, Macrocytic; Child; Child, Preschool; Humans; Infant; Intellectual Disability; Male; Orotic Acid; Purine-Pyrimidine Metabolism, Inborn Errors; Uracil; Uridine | 1969 |
Orotate as a beta-alanine donor for anserine and carnosine biosynthesis, and effects of actinomycin D and azauracil on their pathway.
Topics: Alanine; Amino Acids; Animals; Autoanalysis; Autoradiography; Body Weight; Carbon Isotopes; Chromatography, Paper; Dactinomycin; Depression, Chemical; Dipeptides; Injections, Intramuscular; Injections, Intraperitoneal; Injections, Intravenous; Liver; Male; Muscle Proteins; Muscles; Orotic Acid; Rats; RNA; Skeleton; Stimulation, Chemical; Temperature; Time Factors; Triazines; Uracil | 1969 |
Biosynthesis de novo of purines and pyrimidines in Mesocestoides (Cestoda). I.
Topics: Adenine; Carbon Isotopes; Cestoda; Chromatography, Thin Layer; Glycine; Isoleucine; Nucleic Acids; Orotic Acid; Purines; Pyrimidines; Uracil | 1970 |
Interaction of informational macromolecules with ribosomes. II. Binding of tissue-specific RNA's by ribosomes.
Topics: Animals; Binding Sites; Carbon Isotopes; Cell Nucleus; Centrifugation, Density Gradient; Chemical Phenomena; Chemistry; Coliphages; Kidney; Liver; Organ Specificity; Orotic Acid; Phosphorus Isotopes; Rats; Ribosomes; RNA; Spleen; Tritium; Uracil | 1970 |
Pyrimidine biosynthesis in the chick.
Topics: Amidohydrolases; Animals; Aspartic Acid; Carbon Isotopes; Carbonates; Carboxy-Lyases; Chickens; Cytosine; Liver; Orotic Acid; Pyrimidines; Transferases; Uracil | 1970 |
Pyrimidine nucleotide synthesis in the normal and hypertrophying rat heart. Relative importance of the de novo and "salvage" pathways.
Topics: Animals; Cardiomyopathies; In Vitro Techniques; Male; Myocardium; Nucleotides; Orotic Acid; Phosphotransferases; Pyrimidines; Rats; RNA; Time Factors; Transferases; Tritium; Uracil; Uracil Nucleotides; Uridine | 1970 |
Biosynthesis of ribonucleic acid in mitochondria of rye (Secale cereale) leaves in vitro.
Topics: Carbon Isotopes; Edible Grain; Leucine; Mitochondria; Orotic Acid; Plant Cells; Plants; Protein Biosynthesis; RNA; Ultracentrifugation; Uracil | 1970 |
Control of pyrimidine biosynthesis in human lymphocytes. Induction of glutamine-utilizing carbamyl phosphate synthetase and operation of orotic acid pathway during blastogenesis.
Topics: Adult; Anhydrides; Carbamates; Carbon Dioxide; Carbon Isotopes; Cell Differentiation; Cell Line; Chemical Precipitation; Chromatography, Ion Exchange; Chromatography, Paper; Citrulline; Culture Techniques; Dactinomycin; Electrophoresis; Enzyme Induction; Glutamates; Glutamine; Humans; Hydrolysis; Lectins; Lymphocytes; Orotic Acid; Paper; Phosphoric Acids; Phosphotransferases; Puromycin; Pyrimidines; Quaternary Ammonium Compounds; Sulfates; Uracil; Uracil Nucleotides | 1971 |
Biosynthesis of the formycin family.
Topics: Adenine; Adenine Nucleotides; Anti-Bacterial Agents; Aspartic Acid; Carbon Isotopes; Formates; Glutamates; Glycine; Nocardia; Orotic Acid; Ribose; RNA, Bacterial; Serine; Uracil | 1971 |
[New route of catabolism of orotic acid in microorganisms].
Topics: Barbiturates; Carbon Isotopes; Mycobacterium; Orotic Acid; Polarography; Uracil; Urea | 1967 |
Photosensitized dimerization of pyrimidines.
Topics: Acetone; Acetophenones; Benzophenones; Carbon Isotopes; Chemical Phenomena; Chemistry, Physical; Cytosine; Orotic Acid; Pyrimidines; Radiation Effects; Thermodynamics; Thymine; Ultraviolet Rays; Uracil | 1968 |
Regulatory effect of N6-benzyladenine and pseudothymine (6-methyluracyl) on the synthesis of nucleic acids.
Topics: Adenine; Carbon Isotopes; Orotic Acid; Plants; Purines; Pyrimidines; RNA; Thymine; Uracil | 1968 |
[Peculiarities of the action of certain pyrimidine derivatives on early stages of chick embryogenesis].
Topics: Animals; Chick Embryo; Orotic Acid; Pyrimidines; Triazines; Uracil | 1968 |
Effects of 2-tiouracil and related compounds on pyrimidine metabolism.
Topics: Animals; Carbon Isotopes; Kinetics; Liver; Male; Nucleotides; Orotic Acid; Pyrimidines; Rats; RNA; Thiouracil; Thiourea; Transferases; Uracil; Uridine | 1968 |
3 nuclear RNA fractions and their relationship to polysomal mRNA.
Topics: Adenine; Animals; Cell Nucleus; Cytosine; Guanine; Hybridization, Genetic; Liver; Liver Extracts; Orotic Acid; Phosphorus Isotopes; Rats; Ribosomes; RNA; RNA, Messenger; Tritium; Uracil | 1968 |
Dosimetry in photochemistry.
Topics: Chemical Phenomena; Chemistry; Kinetics; Methods; Orotic Acid; Radiation Effects; Radiometry; Ultraviolet Rays; Uracil | 1968 |
Evidence for the DDT-induced synthesis of messenger ribonucleic acid in Triatoma infestans.
Topics: Animals; Carbon Isotopes; Cell-Free System; Centrifugation, Density Gradient; Chromatography, Ion Exchange; DDT; Hot Temperature; Insecta; Metabolism; Nucleic Acid Denaturation; Orotic Acid; Phenylalanine; Protein Biosynthesis; Ribonucleases; RNA, Messenger; Templates, Genetic; Uracil; Uracil Nucleotides | 1968 |
The capacity of orotic acid production in pyrimidine-deficient mutants of Brevibacterium ammoniagenes.
Topics: Brevibacterium; Chromatography, Paper; Corynebacterium; Culture Media; Glucose; Mutation; Nucleosides; Nucleotides; Orotic Acid; Uracil | 1969 |
Studies on the nuclear and nucleolar ribonucleic acid of regenerating rat liver.
Topics: Adenine; Animals; Cell Nucleolus; Cell Nucleus; Chemistry Techniques, Analytical; Cytosine; Guanine; Hepatectomy; In Vitro Techniques; Liver; Liver Regeneration; Orotic Acid; Phosphates; Rats; RNA; Ultracentrifugation; Uracil | 1965 |
Initial steps in pyrimidine synthesis in Ehrlich ascites carcinoma in vitro. 1. Factors affecting the incorporation of 14C-bicarbonate into carbon 2 of the uracil ring of the acid-soluble nucleotides of intact cells.
Topics: Ammonia; Animals; Azaserine; Bicarbonates; Carbamates; Carcinoma, Ehrlich Tumor; Glucose; Glutamine; In Vitro Techniques; Orotic Acid; Phosphates; Serine; Uracil; Uracil Nucleotides | 1965 |
Differential incorporation of 5'-tritiated pyrimidines into nucleolar RNA of developing root-tip cells.
Topics: Adenine Nucleotides; Autoradiography; Cell Nucleolus; Cell Nucleus; Chromatography; Cytoplasm; Cytosine; Guanine Nucleotides; In Vitro Techniques; Orotic Acid; Plants; RNA; Tritium; Uracil | 1966 |
The relationship between cellular nucleic acids in the developing rat cerebral cortex.
Topics: Adenine; Animals; Animals, Newborn; Brain Chemistry; Cell Nucleus; Cerebral Cortex; Cytosine; DNA; Guanine; In Vitro Techniques; Microsomes; Orotic Acid; Rats; Ribosomes; RNA; Subcellular Fractions; Uracil | 1966 |
Photochemistry of 5-bromouracil in aqueous solution.
Topics: Allantoin; Ammonia; Barbiturates; Chemical Phenomena; Chemistry; Orotic Acid; Oxalates; Radiation Effects; Solutions; Ultraviolet Rays; Uracil; Urea | 1966 |
Operation of orotic acid pathway as the major source of pyrimidines in the hematopoietic mouse spleen.
Topics: Anemia, Hemolytic; Animals; Carbon Dioxide; Chromatography, Paper; Hematopoiesis; Hyperplasia; In Vitro Techniques; Liver; Mice; Orotic Acid; Phenylhydrazines; Spleen; Uracil; Uracil Nucleotides | 1966 |
[On the effect of pyrimidines and their precursors on the diabetogenic activity of alloxan].
Topics: Alloxan; Animals; Aspartic Acid; Barbiturates; Blood Glucose; Cytosine; Diabetes Mellitus, Experimental; Female; Liver Glycogen; Nucleic Acids; Orotic Acid; Pyrimidines; Rats; Thymine; Uracil; Uric Acid | 1966 |
Increased conversion of uridine-5'-phosphate and uridine-5'-triphosphate to cytosine nucleotides by a liver fraction from colchicine-treated rats.
Topics: Adenine Nucleotides; Adenosine Triphosphate; Animals; Carbon Isotopes; Colchicine; Cytosine Nucleotides; Dialysis; In Vitro Techniques; Liver; Male; Nucleosides; Orotic Acid; Phosphates; Proteins; Rats; RNA; Uracil; Uracil Nucleotides; Uridine | 1967 |
Metabolically stable and metabolically labile DNA-like RNA.
Topics: Adenine; Animals; Carbon Isotopes; Carcinoma, Ehrlich Tumor; Cell Nucleus; Cytosine; DNA; DNA, Neoplasm; Guanine; In Vitro Techniques; Liver; Mice; Orotic Acid; RNA; RNA, Neoplasm; Ultracentrifugation; Uracil | 1967 |
Comparison of anabolism of 14C-labelled orotic acid, uracil and uridine in excised pea plants.
Topics: Carbon Isotopes; Chromatography; Nucleotides; Orotic Acid; Plants, Edible; Uracil; Uridine | 1967 |
Photodimerization of pyrimidine nucleic acid derivatives in aqueous solution and the effect of oxygen.
Topics: Carbon Isotopes; Chemical Phenomena; Chemistry; Light; Nucleic Acids; Nucleotides; Orotic Acid; Oxygen; Polymers; Pyrimidines; Solutions; Thymidine; Thymine; Uracil; Uridine | 1967 |
Re-evaluation of the effect of insulin on nucleic acid synthesis in muscle.
Topics: Adenine; Animals; Carbon Isotopes; Diaphragm; Insulin; Muscles; Orotic Acid; Rats; RNA; Uracil | 1967 |
Effect of 6-azauridine on plasma cell tumors of mice: correlation of antitumor effect with inhibition of orotic acid metabolism.
Topics: Animals; Antineoplastic Agents; Carboxy-Lyases; Drug Synergism; Electrophoresis; Enzymes; In Vitro Techniques; Ketones; Mice; Models, Theoretical; Neoplasm Transplantation; Neoplasms, Experimental; Orotic Acid; Plasma Cells; Triazines; Uracil; Urethane | 1967 |
Biosynthesis of RNA in slices of guinea pig cerebral cortex.
Topics: Adenine; Animals; Carbon Isotopes; Cerebral Cortex; Chromatography, Thin Layer; Dactinomycin; Electrophoresis; Guinea Pigs; In Vitro Techniques; Orotic Acid; Paper; Phosphorus Isotopes; RNA; Tritium; Uracil; Uracil Nucleotides; Uridine | 1967 |
Stable isotope dilution analysis of orotic acid and uracil in amniotic fluid.
Topics: Amniotic Fluid; Argininosuccinate Synthase; Chromatography, Liquid; Female; Gas Chromatography-Mass Spectrometry; Humans; Indicator Dilution Techniques; Nitrogen Isotopes; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Pregnancy; Prenatal Diagnosis; Uracil | 1984 |
Effect of purine and pyrimidine limitations on RNA synthesis in Bacillus subtilis.
Topics: Bacillus subtilis; Guanosine; Guanosine Triphosphate; Kinetics; Orotic Acid; Purines; Pyrimidines; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; Transcription, Genetic; Uracil; Uridine Triphosphate | 1984 |
Urinary pyrimidine excretion in arginase deficiency.
Topics: Adolescent; Ammonia; Arginine; Child; Child, Preschool; Chromatography, High Pressure Liquid; Humans; Hyperargininemia; Orotic Acid; Pseudouridine; Pyrimidines; Reference Values; Uracil; Uridine | 1981 |
The enzymatic status of circulating lymphocytes as an index of the regenerative process in the lungs under stimulation with pyrimidine and purine derivatives. A clinical experimental study.
Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Glycerolphosphate Dehydrogenase; Humans; Hypertrophy; Inflammation; Inosine Diphosphate; L-Lactate Dehydrogenase; Lung; Lymphocyte Activation; Lymphocytes; Male; Neutrophils; Orotic Acid; Purines; Pyrimidines; Rats; Regeneration; Succinate Dehydrogenase; Uracil | 1982 |
Assessment of hepatic tissue blood flow with 133Xe clearance technique.
Topics: Animals; Dogs; Liver; Liver Diseases; Male; Microcirculation; Orotic Acid; Rats; Uracil; Xenon Radioisotopes | 1981 |
Facilitated transport of uracil and 5-fluorouracil, and permeation of orotic acid into cultured mammalian cells.
Topics: Animals; Biological Transport; Cell Membrane Permeability; Cells, Cultured; Cricetinae; Cricetulus; Female; Fluorouracil; HeLa Cells; Humans; Leukemia P388; Liver Neoplasms, Experimental; Mice; Orotic Acid; Ovary; Pyrimidines; Rats; Uracil | 1980 |
Argininosuccinic aciduria: clinical and biochemical findings in three children with the late onset form, with special emphasis on cerebrospinal fluid findings of amino acids and pyrimidines.
Topics: Argininosuccinate Lyase; Argininosuccinic Acid; Brain; Brain Chemistry; Child, Preschool; Cytidine; Developmental Disabilities; Female; Humans; Infant; Male; Metabolic Diseases; Orotic Acid; Pyrimidines; Uracil | 1993 |
The role of divalent magnesium in activating the reaction catalyzed by orotate phosphoribosyltransferase.
Topics: Cations, Divalent; Enzyme Activation; Magnesium; Manganese; Orotate Phosphoribosyltransferase; Orotic Acid; Phosphoribosyl Pyrophosphate; Salmonella typhimurium; Substrate Specificity; Uracil | 1993 |
Telomere-associated chromosome breakage in fission yeast results in variegated expression of adjacent genes.
Topics: Adenine; Cell Division; Chromosome Aberrations; DNA, Recombinant; Electrophoresis, Gel, Pulsed-Field; Extrachromosomal Inheritance; Gene Expression Regulation, Fungal; Gene Rearrangement; Genes, Fungal; Leucine; Orotic Acid; RNA, Fungal; Schizosaccharomyces; Uracil | 1994 |
Isolation and transformation of uracil auxotrophs of the lignin-degrading basidiomycete Phanerochaete chrysosporium.
Topics: Ascomycota; Basidiomycota; Drug Resistance, Microbial; Genes, Fungal; Lignin; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Recombination, Genetic; Transformation, Genetic; Uracil | 1993 |
Automated screening system for purine and pyrimidine metabolism disorders using high-performance liquid chromatography.
Topics: Adenine; Adenosine; Autoanalysis; Chromatography, High Pressure Liquid; Humans; Orotic Acid; Pseudouridine; Purine-Pyrimidine Metabolism, Inborn Errors; Uracil; Xanthine; Xanthines | 1995 |
Antagonistic effect of nucleic acid precursors on the anticoccidial activity of 6-azauracil.
Topics: Adenine; Adenosine; Animals; Chickens; Coccidiosis; Coccidiostats; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Eimeria; Food, Fortified; Male; Nucleic Acid Precursors; Orotic Acid; Poultry Diseases; Uracil; Uridine | 1996 |
Development and survival of Drosophila melanogaster fed a diet containing pyrimidine analogs.
Topics: Animals; Bromouracil; Cytosine; Diet; Drosophila melanogaster; Female; Larva; Male; Orotic Acid; Pupa; Pyrimidines; Thymine; Uracil; Uridine Monophosphate | 1997 |
Delayed hypersensitivity to 5-fluorouracil associated with reduced dihydropyrimidine dehydrogenase (DPD) activity.
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Creatinine; Dihydrouracil Dehydrogenase (NADP); Drug Hypersensitivity; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hypersensitivity, Delayed; Leukocytes; Lymphocytes; Male; Orotic Acid; Oxidoreductases; Pseudouridine; Uracil | 1998 |
Radioactivity-based and spectrophotometric assays for isoorotate decarboxylase: identification of the thymidine salvage pathway in lower eukaryotes.
Topics: Ammonium Sulfate; Carbon Dioxide; Carbon Radioisotopes; Carboxy-Lyases; Enzyme Inhibitors; Kinetics; Neurospora crassa; Orotic Acid; Sensitivity and Specificity; Spectrophotometry; Thymidine; Uracil | 1999 |
Identification of the orotidine-5'-phosphate decarboxylase gene and development of a transformation system in the yeast Saccharomyces exiguus Yp74L-3.
Topics: Genes, Fungal; Genetic Vectors; Mutation; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Plasmids; Saccharomyces; Transformation, Genetic; Uracil | 1998 |
Determination of urinary orotic acid and uracil by capillary zone electrophoresis.
Topics: Amino Acid Metabolism, Inborn Errors; Ammonia; Borates; Buffers; Citrulline; Dietary Proteins; Electrophoresis, Capillary; Humans; Hydrogen-Ion Concentration; Infant; Male; Ornithine; Orotic Acid; Syndrome; Uracil | 1999 |
Isolation and transformation of uracil auxotrophs of the edible basidiomycete Pleurotus ostreatus.
Topics: Aspartate Carbamoyltransferase; Blotting, Southern; Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing); DNA, Fungal; Drug Resistance, Microbial; Fungal Proteins; Genetic Vectors; Multienzyme Complexes; Mutation; Orotic Acid; Plasmids; Pleurotus; Saccharomyces cerevisiae Proteins; Transformation, Genetic; Trichoderma; Ultraviolet Rays; Uracil | 1999 |
High spontaneous mutation rate in the hyperthermophilic archaeon Sulfolobus solfataricus is mediated by transposable elements.
Topics: Amino Acid Sequence; Base Sequence; DNA Transposable Elements; DNA, Archaeal; Genome, Archaeal; Molecular Sequence Data; Mutagenesis, Insertional; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Sequence Homology, Amino Acid; Sulfolobus; Uracil | 2000 |
Detection of ornithine transcarbamylase deficiency heterozygotes by measuring of urinary uracil.
Topics: Female; Genetic Carrier Screening; Humans; Models, Biological; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Reference Values; Uracil | 2000 |
Urinary pyrimidine analysis in healthy newborns, infants, children, adults and patients with congenital metabolic diseases.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, Liquid; Humans; Infant; Infant, Newborn; Metabolism, Inborn Errors; Orotic Acid; Pyrimidines; Uracil | 2000 |
Ornithine carbamoyltransferase deficiency presenting with chorea in a female.
Topics: Alanine; Chorea; Female; Glutamine; Humans; Infant; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Uracil | 2000 |
Intra-day variations in urinary pyrimidines in ornithine carbamoyltransferase deficiency and healthy individuals.
Topics: Adult; Child; Child, Preschool; Circadian Rhythm; Female; Humans; Infant; Male; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Pyrimidines; Uracil | 2001 |
Pitfalls in the detection of heterozygosity by allopurinol in a variant form of ornithine carbamoyltransferase deficiency.
Topics: Allopurinol; Child; False Negative Reactions; Female; Genetic Carrier Screening; Humans; Mutation; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Uracil | 2001 |
Non-utilization of radioactive iodinated uracil, uridine, and orotic acid by animal tissues in vivo.
Topics: Neoplasms; Orotic Acid; Uracil; Uridine | 1953 |
Microbiological activities of iodoorotic acid and iodouridine.
Topics: Lactobacillus; Orotic Acid; Streptococcus; Uracil | 1954 |
Some factors affecting the excretion of orotic acid by mutants of Aerobacter aerogenes.
Topics: Biological Transport; Enterobacter aerogenes; Orotic Acid; Uracil | 1954 |
Biological studies of analogs of orotic acid: 6-uracilsulfonic acid, 6-uracilsulfonamide, and 6-uracil methyl sulfone.
Topics: Bacteria; Dimethyl Sulfoxide; Organic Chemicals; Orotic Acid; Sulfones; Uracil | 1956 |
Studies on the mode of action of analogues of orotic acid; 6-uracilsulfonic acid, 6-uracilsulfonamide, and 6-uracil methyl sulfone.
Topics: Dimethyl Sulfoxide; Organic Chemicals; Orotic Acid; Phosphorylases; Sulfones; Uracil | 1956 |
Fluorinated pyrimidines, a new class of tumour-inhibitory compounds.
Topics: Halogenation; Neoplasms; Orotic Acid; Pyrimidines; Uracil | 1957 |
Conversion of uracil and orotate to uridine 5'-phosphate by enzymes in lactobacilli.
Topics: Lactobacillus; Nucleotides; Orotic Acid; Phosphates; Uracil; Uracil Nucleotides; Uridine | 1957 |
Control by uracil of formation of enzymes required for orotate synthesis.
Topics: Escherichia coli; Nucleotides; Orotic Acid; Uracil | 1957 |
The incorporation of [14C] uracil and [14C] orotic acid into RNA in the cytoplasm of Amoeba proteus.
Topics: Amoeba; Animals; Cytoplasm; Invertebrates; Orotic Acid; Proteus; RNA; Uracil | 1959 |
Elimination by the urine of orotic acid and orotidine in man after application of 6-azauracil.
Topics: Biological Transport; Body Fluids; Humans; Male; Nucleosides; Nucleotides; Orotic Acid; Uracil; Uridine | 1960 |
The relationship of uracil, orotic acid and thiouracil in mammalian thyroid tissue.
Topics: Animals; Orotic Acid; Thiouracil; Thyroid Gland; Uracil | 1961 |
Further studies on experimental atherosclerosis and dietary pyrimidines: orotic acid, thiouracil, and uracil in male and female rats.
Topics: Animals; Atherosclerosis; Diet; Female; Male; Orotic Acid; Pyrimidines; Rats; Thiouracil; Uracil | 1960 |
INHIBITORY ACTION OF ADENINE, ADENINENUCLEOSIDES AND NUCLEOTIDES ON THE BIOSYNTHESIS OF PORPHYRINS BY RHODOPSEUDOMONASSPHEROIDES.
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Antimetabolites; Chlorophyll; Levulinic Acids; Metabolism; Nucleosides; Nucleotides; Orotic Acid; Pharmacology; Porphyrins; Research; Rhodopseudomonas; Thymine; Uracil | 1963 |
CHEMICAL REACTIVITY OF THE NUCLEIC ACID BASES. I. ANTIOXIDATIVE ABILITY OF THE NUCLEIC ACIDS AND THEIR RELATED SUBSTANCES ON THE OXIDATION OF UNSATURATED FATTY ACIDS.
Topics: Adenine; Antioxidants; Catechols; Citrates; Copper; Diphosphates; Fats, Unsaturated; Fatty Acids, Unsaturated; Linoleic Acid; Lipid Metabolism; Nucleic Acids; Nucleosides; Orotic Acid; Oxidation-Reduction; Research; RNA; Uracil; Uric Acid; Vitamin E; Xanthines | 1963 |
STUDIES ON THE FORMATION OF OROTIC ACID BY RAT LIVER PREPARATIONS.
Topics: Amidohydrolases; Barbiturates; Diet; Digestion; Liver; Liver Extracts; Metabolism; Orotic Acid; Oxidoreductases; Rats; Research; Uracil | 1963 |
[TREATMENT OF GOUT WITH URACIL-6-CARBOXYLIC ACID AND ITS DERIVATIVES].
Topics: Blood; Body Fluids; Carboxylic Acids; Gout; Humans; Orotic Acid; Pharmacology; Toxicology; Uracil; Uric Acid; Uricosuric Agents; Urine | 1963 |
[INHIBITORY ACTION OF NUCLEOSIDES AND ADENINE NUCLEOTIDES ON THE BIOSYNTHESIS OF PORPHYRINS BY RHODOPSEUDOMONAS SPHEROUIDES].
Topics: Adenine; Adenine Nucleotides; Adenosine Triphosphate; Antimetabolites; Glycine; Ketoglutaric Acids; Levulinic Acids; Nucleosides; Orotic Acid; Pharmacology; Porphyrins; Research; Rhodopseudomonas; Succinates; Thymidine; Thymine; Uracil | 1963 |
THE BIOSYNTHESIS OF THIAMINE. V. STUDIES CONCERNING PRECURSORS OF THE PYRIMIDINE MOIETY.
Topics: Acetates; Aspartic Acid; Carbon Isotopes; Chromatography; Escherichia coli; Formates; Glycine; Ion Exchange Resins; Metabolism; Methionine; Orotic Acid; Pyrimidines; Research; Serine; Sulfonic Acids; Thiamine; Uracil | 1963 |
FACTORS INFLUENCING THE INDUCTION OF FATTY LIVER BY OROTIC ACID.
Topics: Albumins; Caseins; Cytosine; Diet; Fatty Liver; Glycine max; Guanine; Nucleosides; Orotic Acid; Rats; Research; Starvation; Toxicology; Uracil; Xanthines | 1963 |
ARGININE AS A PRECURSOR OF PYRIMIDINES IN STRAIN L-929 FIBROBLASTS INFECTED WITH PLEUROPNEUMONIA-LIKE ORGANISMS.
Topics: Arginase; Arginine; Aspartic Acid; Carbamates; Carbon Isotopes; Connective Tissue; Fibroblasts; Glutamine; Ligases; Metabolism; Mycoplasma; Ornithine; Ornithine Carbamoyltransferase; Orotic Acid; Phosphates; Phosphotransferases; Proline; Proteins; Pyrimidines; Research; Thymidine; Tissue Culture Techniques; Uracil; Urea; Ureohydrolases | 1964 |
FORMATION OF RIBOMONONUCLEOTIDES FROM PURINE AND PYRIMIDINE BASES AND 5'-PHOSPHORIBOSYLPYROPHOSPHATE BY A SALMON MILT EXTRACT.
Topics: Adenine; Adenine Nucleotides; Animals; Carbon Isotopes; Chromatography; Cytosine; Cytosine Nucleotides; Diphosphates; Fishes; Guanine; Guanine Nucleotides; Metabolism; Nucleotides; Orotic Acid; Phosphoribosyl Pyrophosphate; Purines; Pyrimidines; Research; Salmon; Thymine; Tissue Extracts; Tritium; Uracil; Uracil Nucleotides; Xanthines | 1964 |
BIOCHEMICAL EFFECTS OF ETHIDIUM BROMIDE IN MICRO-ORGANISMS.
Topics: Antiprotozoal Agents; Bacillus cereus; DNA; DNA, Bacterial; Escherichia coli; Ethidium; Nucleotides; Orotic Acid; Pharmacology; Research; RNA; RNA, Bacterial; Uracil | 1964 |
ENZYMES OF THE PYRIMIDINE PATHWAY IN ESCHERICHIA COLI. I. SYNTHESIS BY CELLS AND SPHEROPLASTS.
Topics: Amino Acids; Chloramphenicol; Edetic Acid; Escherichia coli; Nucleotides; Ornithine; Ornithine Carbamoyltransferase; Orotic Acid; Oxidoreductases; Pharmacology; Pyrimidines; Research; Spheroplasts; Sucrose; Transferases; Uracil | 1964 |
PATHWAY OF PYRIMIDINE BIOSYNTHESIS IN PREMETAMORPHIC TADPOLES.
Topics: Alanine; Animals; Anura; Aspartic Acid; Carbamates; Carbon Isotopes; Carboxy-Lyases; Glucose; Larva; Liver; Metabolism; Metamorphosis, Biological; Orotic Acid; Phosphates; Pyrimidines; Research; RNA; Succinates; Uracil | 1964 |
URACIL METABOLISM IN TADPOLES DURING THYROXINE-INDUCED METAMORPHOSIS.
Topics: Adenine; Animals; Anura; Carbamates; Cytosine; Glucosyltransferases; Larva; Ligases; Liver; Metabolism; Metamorphosis, Biological; Nucleosides; Orotic Acid; Pharmacology; Phosphates; Ranidae; Research; Thyroxine; Uracil | 1964 |
INFLUENCE OF 6-AZAURACIL ON PYRIMIDINE METABOLISM OF COCKLEBUR LEAF DISCS.
Topics: Carbon Dioxide; Metabolism; Nucleosides; Nucleotides; Orotic Acid; Plants; Pyrimidines; RNA; Uracil; Uracil Nucleotides; Xanthium | 1964 |
[QUANTITATIVE DETERMINATION OF 6-AZAURIDINE, 6-AZAURACIL AND THE AMMONIUM SALT OF OROTIC ACID].
Topics: Ammonium Compounds; Antineoplastic Agents; Azauridine; Chemistry, Pharmaceutical; Nucleosides; Orotic Acid; Pharmacy; Research; Uracil | 1964 |
PYRIMIDINE INCORPORATION INTO NUCLEIC ACIDS OF CORYNEBACTERIA SPP.
Topics: Corynebacterium; DNA; DNA, Bacterial; Nucleic Acids; Orotic Acid; Proteins; Pyrimidines; Research; RNA; RNA, Bacterial; Thymine; Uracil | 1964 |
EFFECTS OF BICARBONATE ON GROWTH OF PASTEURELLA PESTIS. 3. REPLACEMENT OF BICARBONATE BY PYRIMIDINES.
Topics: Arginine; Bicarbonates; Carbamates; Carbon Dioxide; Citrulline; Culture Media; Cytosine; Metabolism; Orotic Acid; Pharmacology; Phosphates; Pyrimidines; Research; Uracil; Yersinia pestis | 1964 |
3-RIBOSYLPURINES. I. SYNTHESIS OF (3-RIBOSYLURIC ACID) 5'-PHOSPHATE AND (3-RIBOSYLXANTHINE) 5'-PHOSPHATE BY A PYRIMIDINE RIBONUCLEOTIDE PYROPHOSPHORYLASE OF BEEF ERYTHROCYTES.
Topics: Animals; Carbon Isotopes; Cattle; Chemical Phenomena; Chemistry; Chromatography; Erythrocytes; Glucosyltransferases; Metabolism; Nucleotides; Orotic Acid; Phosphates; Pterins; Purines; Pyrimidines; Research; Ribonucleosides; Ribonucleotides; Ribose; Spectrophotometry; Uracil; Uric Acid; Xanthines | 1964 |
[STUDY OF THE PASSAGE OF CERTAIN PRECURSORS OF NUCLEIC ACIDS FROM THE CEREBROSPINAL FLUID INTO THE CENTRAL NERVOUS SYSTEM].
Topics: Adenine; Blood; Blood-Brain Barrier; Carbon Isotopes; Guanine; Nucleic Acids; Nucleosides; Nucleotides; Orotic Acid; Physiology; Radiometry; Rats; Research; Uracil; Uridine | 1964 |
COMPARISON OF THE URACIL CATABOLIC ACTIVITY OF LIVER CELL SUSPENSIONS AND SLICES.
Topics: Carbon Dioxide; Carbon Isotopes; Carcinoma, Hepatocellular; Hepatocytes; Liver; Liver Neoplasms; Metabolism; Orotic Acid; Perfusion; Rats; Research; RNA; Suspensions; Uracil | 1964 |
EFFECT OF PURINES AND SOME OF THEIR ANALOGUES ON PROTEIN AND RNA SYNTHESIS IN ISOLATED NUCLEI.
Topics: Antibody Formation; Antimetabolites; Antineoplastic Agents; Carbon Isotopes; Cell Nucleus; Cytosine; Guanine; Leucine; Leukocytes; Lysine; Mercaptopurine; Metabolism; Orotic Acid; Pharmacology; Proteins; Purines; Research; RNA; Thioguanine; Uracil; Uric Acid; Xanthines | 1964 |
EFFECTS OF THIOACETAMIDE ON NUCLEAR AND NUCLEOLAR RNA OF THE RAT LIVER.
Topics: Adenine; Amides; Anesthetics, Local; Carbon Isotopes; Cell Nucleolus; Cell Nucleus; Cytosine; Guanine; Liver; Metabolism; Orotic Acid; Rats; Research; RNA; Sulfhydryl Compounds; Thioacetamide; Uracil | 1965 |
OXONATE AND OTHER RELATED ANTIMETABOLITES OF THE SYNTHESIS DE NOVO OF PYRIMIDINE NUCLEOTIDES.
Topics: Antimetabolites; Autoradiography; Leukemia; Leukemia, Experimental; Liver; Liver Extracts; Metabolism; Nucleotides; Orotic Acid; Pharmacology; Phosphotransferases; Pyrimidine Nucleotides; Pyrimidines; Rats; Research; Uracil | 1964 |
OROTIC ACID-INDUCED FATTY LIVER. METABOLIC STUDIES IN CONVENTIONAL AND GERM-FREE RATS.
Topics: Diet; Fatty Liver; Feces; Germ-Free Life; Intestinal Absorption; Intestines; Metabolism; Nucleosides; Orotic Acid; Rats; Research; Toxicology; Uracil; Uracil Nucleotides; Uridine; Urine | 1965 |
THIOURACIL-PYRIMIDINE RELATIONSHIPS IN THYROID AND OTHER TISSUES.
Topics: Animals; Carbon Dioxide; Carbon Isotopes; Cattle; Liver; Metabolism; Organ Size; Orotic Acid; Pharmacology; Pyrimidines; Rats; Research; RNA; Thiouracil; Thymine; Thymus Gland; Thyroid Gland; Uracil; Uracil Nucleotides | 1965 |
NUCLEIC ACID SYNTHESIS IN NORMAL AND GOITROUS RAT THYROID.
Topics: Antithyroid Agents; Carbon Isotopes; Chromatography; Cytosine Nucleotides; DNA; Glucosyltransferases; Goiter; Metabolism; Orotic Acid; Pharmacology; Phosphotransferases; Rats; Research; RNA; Spectrophotometry; Thiouracil; Thyroid Gland; Uracil; Uracil Nucleotides | 1965 |
METABOLIC EFFECTS OF AN ANTIBIOTIC, NSC-51954, ON SUSCEPTIBLE AND RESISTANT TUMOR CELLS.
Topics: Adenine; Animals; Anti-Bacterial Agents; Carbon Isotopes; Carcinoma, Ehrlich Tumor; DNA; DNA, Neoplasm; Guanine; Guanine Nucleotides; Leukemia; Leukemia, Experimental; Mice; Neoplasm Proteins; Neoplasms; Orotic Acid; Pharmacology; Phosphotransferases; Proteins; Radiometry; Research; RNA; RNA, Neoplasm; Sarcoma 180; Toxicology; Uracil | 1965 |
EFFECT OF AZASERINE ON THE INCORPORATION OF 14-C-LABELED PURINES AND PYRIMIDINES INTO ACID-SOLUBLE AND NUCLEIC ACID FRACTIONS OF TRYPANOSOMA EQUIPERDUM.
Topics: Adenine; Amino Acids; Azaserine; Cytosine; Cytosine Nucleotides; DNA; Glutamine; Guanine; Hypoxanthines; Leucine; Metabolism; Nucleic Acids; Orotic Acid; Pharmacology; Purines; Pyrimidines; Research; RNA; Thymine; Trypanosoma; Tryptophan; Tyrosine; Uracil; Uracil Nucleotides | 1965 |
TRANSCARBAMYLASE ACTIVITY IN FETAL LIVER AND IN LIVER OF PARTIALLY HEPATECTOMIZED PARABIOTIC RATS.
Topics: Cell Division; Enzyme Precursors; Erythrocyte Count; Fetus; Guinea Pigs; Hepatectomy; Ligases; Liver; Liver Diseases; Liver Regeneration; Nucleosides; Ornithine; Ornithine Carbamoyltransferase; Orotic Acid; Parabiosis; Pyrimidines; Rats; Research; Transferases; Uracil; Urea; Uridine | 1965 |
MICROBIOLOGICAL DECARBOXYLATION OF OROTIC ACID TO URACIL.
Topics: Carboxy-Lyases; Decarboxylation; Escherichia coli; Hydrogen-Ion Concentration; Metabolism; Orotic Acid; Polarography; Research; Spectrophotometry; Uracil | 1965 |
METABOLISM OF TISSUE CELLS IN SUSPENSION. SYNTHESIS OF RIBONUCLEIC ACID BY LEIVER CELLS IN SUSPENSION.
Topics: Adenine; Liver; Metabolism; Orotic Acid; Phosphates; Rats; Research; RNA; Uracil | 1965 |
[Activity of fluorinated pyrimidines on the growth of human tumor cells cultured in vitro].
Topics: Biological Phenomena; Halogenation; In Vitro Techniques; Neoplasms; Nucleosides; Nucleotides; Orotic Acid; Physiological Phenomena; Pyrimidines; Uracil | 1959 |
Regulation of pyrimidine nucleotide formation in Pseudomonas reptilivora.
Topics: Adenosine Triphosphate; Aspartate Carbamoyltransferase; Aspartic Acid; Dihydroorotase; Dihydroorotate Dehydrogenase; Diphosphates; Enzyme Inhibitors; Gene Expression Regulation; Gene Expression Regulation, Bacterial; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Oxidoreductases Acting on CH-CH Group Donors; Pseudomonas; Pyrimidine Nucleotides; Uracil; Uridine Monophosphate | 2004 |
A suspected case of ornithine transcarbamylase deficiency in a cat.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Bile Acids and Salts; Cat Diseases; Cats; Female; Gas Chromatography-Mass Spectrometry; Hyperammonemia; Ornithine Carbamoyltransferase; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Portasystemic Shunt, Surgical; Portography; Postprandial Period; Uracil; Urine | 2004 |
Alterations in pyrimidine nucleotide metabolism as an early signal during the execution of programmed cell death in tobacco BY-2 cells.
Topics: Apoptosis; Dactinomycin; Hydrogen Peroxide; Nicotiana; Nitric Oxide; Orotic Acid; Phosphotransferases (Alcohol Group Acceptor); Pyrimidine Nucleotides; Signal Transduction; Thymidine; Time Factors; Transferases; Uracil; Uridine | 2004 |
Urinary uracil in female patients with ornithine transcarbamylase deficiency.
Topics: Child, Preschool; Female; Heterozygote; Humans; Hyperammonemia; Infant; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Uracil | 2005 |
Comparative studies on pyrimidine metabolism in excised cotyledons of Pinus radiata during shoot formation in vitro.
Topics: Benzyl Compounds; Cotyledon; In Vitro Techniques; Kinetin; Orotate Phosphoribosyltransferase; Orotic Acid; Pentosyltransferases; Pinus; Plant Shoots; Purines; Pyrimidine Nucleotides; Pyrimidines; Uracil; Uridine; Uridine Kinase | 2007 |
Control of ribosome turnover during growth of the haloalkaliphilic archaeon Natronococcus occultus.
Topics: Carbon Radioisotopes; Culture Media; Gene Expression Regulation, Archaeal; Hydrogen-Ion Concentration; Natronococcus; Orotic Acid; Ribosomes; RNA, Ribosomal; Sodium Chloride; Time Factors; Tritium; Uracil | 2006 |
A fluoroorotic acid-resistant mutant of Arabidopsis defective in the uptake of uracil.
Topics: Arabidopsis; Arabidopsis Proteins; Biological Transport; Chromosome Mapping; Chromosomes, Plant; Escherichia coli; Escherichia coli Proteins; Genetic Complementation Test; Membrane Transport Proteins; Mutation; Orotic Acid; Uracil | 2006 |
Characterization of Treponema denticola pyrF encoding orotidine-5'-monophosphate decarboxylase.
Topics: Bacterial Proteins; Culture Media; Drug Resistance, Bacterial; Genetic Complementation Test; Mutation; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pyrimidines; Treponema denticola; Uracil | 2007 |
Transformation by complementation of a uracil auxotroph of the hyper lignin-degrading basidiomycete Phanerochaete sordida YK-624.
Topics: Gene Expression Regulation, Fungal; Genetic Complementation Test; Glyceraldehyde-3-Phosphate Dehydrogenases; Green Fluorescent Proteins; Industrial Microbiology; Lignin; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Phanerochaete; Transformation, Genetic; Uracil | 2007 |
Classical genetics.
Topics: Autotrophic Processes; Crosses, Genetic; Genes, Essential; Genetic Complementation Test; Mutagenesis; Mutation; Nitrosoguanidines; Orotic Acid; Pichia; Uracil | 2007 |
Improved protocols for functional analysis in the pathogenic fungus Aspergillus flavus.
Topics: Antifungal Agents; Aspergillus flavus; Blotting, Southern; Drug Resistance, Fungal; Genes, Fungal; Genetic Complementation Test; Mutagenesis; Mutagenesis, Insertional; Orotic Acid; Phleomycins; Polymerase Chain Reaction; Protoplasts; Spores, Fungal; Transformation, Genetic; Uracil | 2007 |
Gene tagging and gene replacement using recombinase-mediated cassette exchange in Schizosaccharomyces pombe.
Topics: Amino Acid Sequence; Base Sequence; Cell Cycle Proteins; DNA-Binding Proteins; Gene Targeting; Genes, Fungal; Green Fluorescent Proteins; Integrases; Molecular Sequence Data; Orotic Acid; Polymerase Chain Reaction; Recombination, Genetic; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transglutaminases; Uracil | 2008 |
Stochastic switching as a survival strategy in fluctuating environments.
Topics: Adaptation, Biological; Bacterial Proteins; Cell Survival; Environment; Fluorouracil; Fungal Proteins; Galactokinase; Galactose; Luminescent Proteins; Models, Biological; Orotic Acid; Phenotype; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stochastic Processes; Time Factors; Uracil | 2008 |
Differentiation of 2-alkylthioorotic acids, methyl and ethyl 2-alkylthioorotates and hydrazides of 2-alkylthioorotic acids by using electron ionization mass spectra.
Topics: Esters; Humans; Hydrazines; Isomerism; Orotic Acid; Spectrometry, Mass, Electrospray Ionization; Sulfur Compounds; Uracil; Urea; Vitamins | 2008 |
Orotic acid decarboxylation in water and nonpolar solvents: a potential role for desolvation in the action of OMP decarboxylase.
Topics: Acetic Acid; Decarboxylation; Hydrogen-Ion Concentration; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Solubility; Solvents; Temperature; Uracil; Water | 2009 |
Identification of the UMP synthase gene by establishment of uracil auxotrophic mutants and the phenotypic complementation system in the marine diatom Phaeodactylum tricornutum.
Topics: Amino Acid Sequence; Biosynthetic Pathways; Diatoms; Genetic Complementation Test; Humans; Molecular Sequence Data; Multienzyme Complexes; Mutagenesis; Mutation; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Phenotype; Phylogeny; Protein Structure, Tertiary; RNA Interference; Sequence Alignment; Uracil | 2011 |
The function of oxalic acid in the human metabolism.
Topics: Humans; Intracellular Space; Orotic Acid; Oxalic Acid; Uracil | 2011 |
Development of pyrF-based gene knockout systems for genome-wide manipulation of the archaea Haloferax mediterranei and Haloarcula hispanica.
Topics: Alkyl and Aryl Transferases; Amino Acid Sequence; Archaeal Proteins; Culture Media; Gene Knockout Techniques; Genetic Vectors; Geranylgeranyl-Diphosphate Geranylgeranyltransferase; Haloarcula; Haloferax mediterranei; Molecular Sequence Data; Orotic Acid; Plasmids; Recombination, Genetic; Sequence Deletion; Uracil | 2011 |
Distinct fluctuations in nucleotide metabolism accompany the enhanced in vitro embryogenic capacity of Brassica cells over-expressing SHOOTMERISTEMLESS.
Topics: Adenine Phosphoribosyltransferase; Adenosine Kinase; Biological Transport; Brassica napus; Carbon Isotopes; Down-Regulation; Gene Expression; Germination; Meristem; Orotic Acid; Plant Proteins; Pollen; Purine Nucleotides; Pyrimidine Nucleosides; Time Factors; Uracil; Uridine | 2011 |
Plastid uridine salvage activity is required for photoassimilate allocation and partitioning in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Biomass; Cellulose; Fluorouracil; Isoenzymes; Light; Lignin; Mutagenesis, Insertional; Orotic Acid; Pentosyltransferases; Phenotype; Plant Leaves; Plants, Genetically Modified; Plastids; Recombinant Fusion Proteins; Seeds; Starch; Uracil; Uridine; Uridine Kinase | 2011 |
Counterselection system for Geobacillus kaustophilus HTA426 through disruption of pyrF and pyrR.
Topics: Bacterial Proteins; Drug Resistance, Bacterial; Gene Knockout Techniques; Genetics, Microbial; Geobacillus; Molecular Biology; Orotic Acid; Recombination, Genetic; Selection, Genetic; Uracil | 2012 |
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.
Topics: Amides; Animals; Biological Transport; Cell Line; Deoxyuridine; Fluorouracil; Gene Knockout Techniques; Mice; Multienzyme Complexes; Orotate Phosphoribosyltransferase; Orotic Acid; Orotidine-5'-Phosphate Decarboxylase; Pyrazoles; Pyrimidines; Ribonucleosides; Ribose; Transfection; Trypanocidal Agents; Trypanosoma brucei brucei; Uracil; Uridine; Uridine Monophosphate; Virulence | 2013 |
High-throughput tandem mass spectrometry multiplex analysis for newborn urinary screening of creatine synthesis and transport disorders, Triple H syndrome and OTC deficiency.
Topics: Biomarkers; Creatine; Creatinine; Filtration; Glycine; Humans; Hyperammonemia; Infant, Newborn; Ornithine; Ornithine Carbamoyltransferase Deficiency Disease; Orotic Acid; Paper; Reference Values; Reproducibility of Results; Tandem Mass Spectrometry; Uracil; Urea Cycle Disorders, Inborn; Urinalysis | 2014 |
Identification of a small molecule that simultaneously suppresses virulence and antibiotic resistance of Pseudomonas aeruginosa.
Topics: Animals; Anti-Bacterial Agents; Biofilms; Disease Models, Animal; Drug Discovery; Drug Resistance, Bacterial; Gene Expression Regulation, Bacterial; Genes, Bacterial; Mice; Microbial Sensitivity Tests; Mutation; Orotic Acid; Phenotype; Pseudomonas aeruginosa; Pseudomonas Infections; Pyocyanine; Type III Secretion Systems; Uracil; Virulence; Virulence Factors | 2016 |
Putative orotate transporter of Cryptococcus neoformans, Oat1, is a member of the NCS1/PRT transporter super family and its loss causes attenuation of virulence.
Topics: Biological Transport; Cryptococcus neoformans; Gene Expression Regulation, Fungal; Membrane Transport Proteins; Mutation; Nitrogen; Orotic Acid; Uracil | 2017 |
Recombinant cell-lysate-catalysed synthesis of uridine-5'-triphosphate from nucleobase and ribose, and without addition of ATP.
Topics: Adenosine Triphosphate; Catalysis; Escherichia coli; Hydrolysis; Orotic Acid; Recombination, Genetic; Ribose; Uracil; Uridine Triphosphate | 2019 |
CRISPR-Cas9 induces point mutation in the mucormycosis fungus Rhizopus delemar.
Topics: CRISPR-Associated Protein 9; CRISPR-Cas Systems; Genes, Fungal; Genetic Vectors; Orotate Phosphoribosyltransferase; Orotic Acid; Point Mutation; Rhizopus; Uracil | 2019 |