orobol and psi-tectorigenin

orobol has been researched along with psi-tectorigenin* in 1 studies

Other Studies

1 other study(ies) available for orobol and psi-tectorigenin

ArticleYear
Isoflavonoids, genistein, psi-tectorigenin, and orobol, increase cytoplasmic free calcium in isolated rat hepatocytes.
    Biochemical and biophysical research communications, 1992, Jan-31, Volume: 182, Issue:2

    Isoflavonoid compounds, genistein, psi-tectorigenin and orobol have been implicated as inhibitors of tyrosine-specific protein kinase and phosphatidylinositol turnover. These compounds have been frequently used as a pharmacological tool to assess signal transduction pathways in various cell systems. In the course of analyzing signaling pathways in rat hepatocytes, we obtained an unexpected finding that these compounds transiently increase cytoplasmic free calcium. Since the Ca2+ mobilizing effect was observed in 1 microM calcium containing buffer, the source of the Ca2+ may be intracellular stores. Thus, when interpreting data obtained using these compounds, caution is needed.

    Topics: Aequorin; Animals; Calcimycin; Calcium; Cells, Cultured; Cytosol; Enzyme Inhibitors; Flavonoids; Genistein; Isoflavones; Kinetics; Liver; Male; Protein-Tyrosine Kinases; Rats; Rats, Inbred Strains

1992