ornithine has been researched along with mitoguazone in 94 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 94 (100.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Alexandre, H | 1 |
Linebaugh, BE; Mulder, JA; Rillema, JA | 1 |
Scamans, E; Tyms, AS; Williamson, JD | 1 |
Emanuelsson, H; Heby, O | 1 |
Brawley, JV; Ferro, AJ | 1 |
Hölttä, E; Hovi, T; Jänne, J | 1 |
Morris, DR; Seyfried, CE | 1 |
Alhonen-Hongisto, L; Jänne, J; Kallio, A; Pösö, H | 1 |
Brinkley, BR; Nishioka, K; Rao, PN; Sunkara, PS | 1 |
Andersson, G; Gray, JW; Heby, O | 1 |
Paul, D; Rupniak, HT | 1 |
Knutson, JC; Morris, DR | 1 |
Hölttä, E; Jänne, J; Pohjanpelto, P | 1 |
Abdel-Monem, MM; Newton, NE | 1 |
Jorstad, CM; Morris, DR; Seyfried, CE | 1 |
Adachi, K; Inoue, H; Kato, Y; Takeda, Y; Takigawa, M | 1 |
Keir, HM; Wallace, HM | 1 |
Dunzendorfer, U; Knöner, M | 1 |
Endoh, F; Fujimoto, S; Igarashi, K; Kawata, S; Miyazaki, M; Ohta, M; Shimura, T; Shrestha, RD; Sugasawa, H; Takahashi, O | 3 |
Endoh, F; Fujimoto, S; Igarashi, K; Miyazaki, M; Ohta, M; Okui, K; Shrestha, RD; Togawa, Y | 1 |
Levin, VA | 1 |
Hidaka, H; Kawakami, K; Ohmura, T; Onoue, K; Yamamoto, Y | 1 |
Członkowska, M; Guszkiewicz, A; Zwierzchowski, L | 1 |
Ask, A; Heby, O; Oredsson, SM; Persson, L | 1 |
Kingsnorth, AN | 1 |
Romijn, JC; Splinter, TA | 1 |
Seidenfeld, J; Williams-Ashman, HG | 1 |
Ajani, JA; Grossie, VB; Nishioka, K; Ota, DM; Stephens, LC | 1 |
Alhonen-Hongisto, L; Levin, VA; Marton, LJ | 1 |
Jänne, J; Käpyaho, K; Sinervirta, R | 1 |
Kramer, DL; Paul, B; Porter, CW | 1 |
Fujimoto, S; Igarashi, K; Miyazaki, M; Okui, K; Shrestha, RD | 1 |
Franzen, MA; Mitchell, JL; Qasba, P; Stofko, RE | 1 |
Manni, A; Pontari, M; Wright, C | 1 |
Pegg, AE; Shirahata, A | 1 |
Lawson, DE; Steeves, RM | 1 |
Deen, DF; Feuerstein, BG; Marton, LJ | 1 |
Lawson, DM; Ofenstein, JP; Rillema, JA | 1 |
Jenkins, JJ; Klein, J; McCullough, JL; Peckham, P; Weinstein, GD | 1 |
Dunzendorfer, U | 1 |
Landahl, HD; Levin, VA | 1 |
Heby, O; Linden, M; Oredsson, SM | 1 |
Jänne, J; Käpyaho, K; Kousa, M; Lauharanta, J; Linnamaa, K; Mustakallio, K | 1 |
Jänne, J; Käpyaho, K; Kariniemi, AL; Virtanen, I | 1 |
Burchenal, JH; Warrell, RP | 1 |
Tyms, AS; Williamson, JD | 1 |
Gordon, AM; Keir, HM; Pearson, CK; Wallace, HM | 1 |
Alhonen-Hongisto, L; Jänne, J; Kallio, A; Seppänen, P | 1 |
Balis, ME; Dunzendorfer, U; Kleinert, E; Relyea, NM; Whitmore, WF | 1 |
Alhonen-Hongisto, L; Jänne, J; Seppänen, P | 4 |
Friend, DS; Marton, LJ; Oredsson, SM | 1 |
Chang, CC; Prakash, NJ; Sjoerdsma, A; Sunkara, PS | 1 |
Laitinen, SI; Pajunen, AE | 1 |
Jänne, J; Käpyaho, K | 1 |
Dunzendorfer, U; Kleinert, E; Whitmore, WF | 1 |
Jänne, J; Käpyaho, K; Lauharanta, J | 2 |
Hietala, OA; Laitinen, PH; Lapinjoki, SP; Pajunen, AE; Pulkka, AE | 1 |
Jänne, J; Kallio, A | 1 |
Burchenal, JH; Coonley, CJ; Warrell, RP | 1 |
Jenkins, JJ; McCullough, JL; Rosenblum, MG; Weinstein, GD | 1 |
Endoh, F; Fujimoto, S; Igarashi, K; Miyazaki, M; Ohyama, Y; Okui, K; Shimura, T; Shrestha, RD; Sugasawa, H; Takahashi, O | 1 |
Kramer, DL; Porter, CW; Wiseman, A; Zychlinski, L | 1 |
Herr, HW; Kleinert, EL; Relyea, NM; Whitmore, WF | 1 |
Covey, DF; Fair, WR; Heston, WD; Kadmon, D | 1 |
Balis, ME; Dunzendorfer, U; Fogh, J; Releyea, N; Whitmore, WF | 1 |
Jänne, J; Kallio, A; Nikula, P | 1 |
Herr, HW; Kleinert, EL | 1 |
Jänne, J; Kallio, A; Käpyaho, K | 1 |
Alhonen-Hongisto, L; Elo, H; Fagerström, R; Jänne, J; Laine, R | 1 |
Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF | 1 |
Alhonen-Hongisto, L; Elo, H; Fagerström, R; Jänne, J; Lumme, P; Seppänen, P | 1 |
Marton, LJ; Oredsson, SM | 1 |
Igarashi, K; Morris, DR | 1 |
Borcich, JK; Byrd, D; Campbell, J; Davis, RL; Levin, VA | 1 |
Gutin, PH; Wilson, CB | 1 |
Campione, AL; Van Winkle, LJ | 2 |
Deen, DF; Marton, LJ; Seidenfeld, J | 1 |
Fozard, JR; Grove, J; Prakash, NJ | 1 |
Alhonen-Hongisto, L; Jänne, J; Seppänen, P; Siimes, M | 2 |
Erwin, BG; Florini, JR; Pegg, AE; Richman, RA; Stoscheck, CM | 1 |
Jänne, J; Käpyaho, K; Linnamaa, K | 1 |
Seppänen, P | 1 |
Fuller, DJ; Gerner, EW | 1 |
Fujimoto, S; Hirose, S; Igarashi, K; Okui, K; Shrestha, RD; Terao, K | 1 |
Bellett, AJ; Cheetham, BF | 1 |
Grove, J; Koch-Weser, J; Mamont, PS; Prakash, NJ; Schechter, PJ; Sjoerdsma, A | 1 |
5 review(s) available for ornithine and mitoguazone
Article | Year |
---|---|
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Eflornithine; Ependymoma; Fluorouracil; Glioblastoma; Humans; Hydroxyurea; Lomustine; Medulloblastoma; Methotrexate; Mitoguazone; Mitolactol; Neoplasm Recurrence, Local; Ornithine; Prednisone; Risk; Thioguanine; Vincristine | 1985 |
The chemotherapeutic potential of polyamine antimetabolites.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Body Weight; Cell Division; Cell Line; Child; Drug Interactions; Eflornithine; Female; Humans; Mice; Mitoguazone; Neoplasms; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats | 1986 |
Aspects of the biochemical pharmacology of methyl glyoxal bis(guanylhydrazone).
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Carnitine; Cell Division; DNA Replication; Eflornithine; Energy Metabolism; Humans; Kinetics; Leukemia; Male; Mitochondria; Mitoguazone; Nucleic Acids; Ornithine; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Polyamines; Protein Biosynthesis; Putrescine; Virus Replication | 1986 |
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Eruptions; Drug Therapy, Combination; Eflornithine; Esophageal Neoplasms; Guanidines; Head and Neck Neoplasms; Humans; Kidney Neoplasms; Leukemia; Leukemia L1210; Lung Neoplasms; Mice; Mitoguazone; Muscular Diseases; Nausea; Neoplasms; Ornithine; Polyamines; Stilbamidines; Structure-Activity Relationship | 1983 |
Use of polyamine antimetabolites in experimental tumours and in human leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Therapy, Combination; Eflornithine; Humans; Leukemia; Mitoguazone; Neoplasms, Experimental; Ornithine; Polyamines | 1981 |
1 trial(s) available for ornithine and mitoguazone
Article | Year |
---|---|
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Eruptions; Drug Therapy, Combination; Eflornithine; Esophageal Neoplasms; Guanidines; Head and Neck Neoplasms; Humans; Kidney Neoplasms; Leukemia; Leukemia L1210; Lung Neoplasms; Mice; Mitoguazone; Muscular Diseases; Nausea; Neoplasms; Ornithine; Polyamines; Stilbamidines; Structure-Activity Relationship | 1983 |
89 other study(ies) available for ornithine and mitoguazone
Article | Year |
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[Effect of inhibitors of polyamine biosynthesis on primary differentiation of mouse egg].
Topics: Animals; Cell Differentiation; Cells, Cultured; Female; Fertilization; Guanidines; Mice; Mitoguazone; Ornithine; Ovum; Putrescine | 1978 |
Regulation of casein synthesis by polyamines in mammary gland explants of mice.
Topics: Animals; Arginine; Caseins; Cyclic AMP; Cyclic GMP; Female; Hydrocortisone; In Vitro Techniques; Insulin; Mammary Glands, Animal; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase; Phospholipases; Polyamines; Prolactin; Prostaglandins F; Protein Biosynthesis; Putrescine; Spermidine; Spermine; Transcription, Genetic | 1977 |
Polyamine metabolism in MRC5 cells infected with different herpesviruses.
Topics: Adenosylmethionine Decarboxylase; Carboxy-Lyases; Cell Line; Cell Transformation, Viral; Cytomegalovirus; Fibroblasts; Herpesviridae; Humans; Mitoguazone; Ornithine; Ornithine Decarboxylase; Polyamines; Spermidine; Spermine; Virus Replication | 1979 |
Inhibition of putrescine synthesis blocks development of the polychete Ophryotrocha labronica at gastrulation.
Topics: Animals; Embryo, Nonmammalian; Female; Mitoguazone; Ornithine; Polychaeta; Putrescine; Spermine; Time Factors; Zygote | 1978 |
Polyamine biosynthesis during germination of yeast ascospores.
Topics: Mitoguazone; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Saccharomyces cerevisiae; Spores, Fungal | 1979 |
Suppression of the formation of polyamines and macromolecules by DL-alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in phytohaemagglutinin-activated human lymphocytes.
Topics: Blood Proteins; DNA; Dose-Response Relationship, Drug; Guanidines; Lymphocyte Activation; Lymphocytes; Macromolecular Substances; Mitoguazone; Ornithine; Phytohemagglutinins; Polyamines; RNA | 1979 |
Relationship between inhibition of polyamine biosynthesis and DNA replication in activated lymphocytes.
Topics: Animals; Cattle; Cell Division; DNA Replication; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Mitoguazone; Ornithine; Polyamines; Thymine Nucleotides | 1979 |
Effect of inhibitors on ornithine and adenosylmethionine decarboxylases on the synthesis of deoxyribonucleic acid in Ehrlich ascites cells in vivo.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Diamines; DNA, Neoplasm; Female; Guanidines; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine; Time Factors | 1979 |
Role of polyamines in cytokinesis of mammalian cells.
Topics: Cell Division; Cell Line; Cytoskeleton; Mitoguazone; Ornithine; Putrescine; Spermidine; Spermine | 1979 |
Interference with S and G2 phase progression by polyamine synthesis inhibitors.
Topics: Cell Cycle; Cell Line; DNA; Guanidines; Interphase; Mitoguazone; Ornithine | 1978 |
Lack of a correlation between polyamine synthesis and DNA synthesis by cultured rat liver cells and fibroblasts.
Topics: Blood; Cell Cycle; Cells, Cultured; DNA; Interphase; Kinetics; Mitoguazone; Ornithine; Polyamines | 1978 |
Cellular polyamine depletion reduces DNA synthesis in isolated lymphocyte nuclei.
Topics: Animals; Cattle; Cell Nucleus; DNA; DNA Replication; Guanidines; Kinetics; Lymphocytes; Mitoguazone; Ornithine; Putrescine; Spermidine; Spermine | 1978 |
Dissociation of the early antiproliferative action of methylglyoxal bis(guanylhydrazone) from polyamine depletion. A comparison of the effects of DL-alpha-difluromethyl ormithine and methylglyoxal bis(guanylhydrazone) on the growth of human fibroblasts.
Topics: Cell Division; Cells, Cultured; DNA; Fibroblasts; Guanidines; Humans; Mitoguazone; Ornithine; Polyamines; Thymidine Kinase | 1979 |
Inhibitors of polyamine biosynthesis. 4. Effects of alpha-methyl-(+/-)-ornithine and methylglyoxal bis(guanylhydrazone) on growth and polyamine content of L1210 leukemic cells of mice.
Topics: Animals; Cell Division; Cells, Cultured; DNA, Neoplasm; Guanidines; Leukemia L1210; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine | 1977 |
Inhibition of the synthesis of polyamines and DNA in activated lymphocytes by a combination of alpha-methylornithine and methylglyoxal bis(guanylhydrazone).
Topics: Animals; Cattle; Cell Division; Concanavalin A; DNA; DNA Replication; Drug Interactions; Guanidines; In Vitro Techniques; Lymphocyte Activation; Lymphocytes; Mitoguazone; Ornithine; Polyamines; Protein Biosynthesis; Putrescine; RNA; Spermidine; Spermine | 1977 |
Effect of DL-alpha-hydrazino-delta-aminovaleric acid, an inhibitor of ornithine decarboxylase, on polyamine metabolism in isoproterenol-stimulated mouse parotid glands.
Topics: Adenosylmethionine Decarboxylase; Animals; Binding, Competitive; Carboxy-Lyases; DNA; Hydrazines; In Vitro Techniques; Isoproterenol; Male; Mice; Mitoguazone; Mitosis; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Parotid Gland; Polyamines; Putrescine; RNA; Spermidine; Spermine; Stimulation, Chemical; Valine | 1975 |
Factors affecting polyamine excretion from mammalian cells in culture. Inhibitors of polyamine biosynthesis.
Topics: Acetylation; Animals; Canavanine; Cell Line; Cricetinae; DNA; Kidney; Mitoguazone; Ornithine; Polyamines; Proteins; Pyruvaldehyde; RNA | 1986 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Carcinoma; Eflornithine; Estrogens; Humans; Male; Mitoguazone; Neoplasm Metastasis; Ornithine; Ornithine Decarboxylase Inhibitors; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatitis; Putrescine; Rats; Spermidine; Spermine | 1985 |
[Anticancer treatment with a combination of antimetabolites of polyamine and pyrimidine].
Topics: Animals; DNA Replication; Drug Therapy, Combination; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Nude; Mitoguazone; Ornithine; Polyamines; Spermine; Stomach Neoplasms | 1985 |
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoma; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Ornithine; Stomach Neoplasms | 1986 |
Induction and regulation of human interleukin 2 gene expression: significance of protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Bucladesine; Cyclic AMP; Cyclic GMP; Dibutyryl Cyclic GMP; Dinoprostone; Enzyme Activation; Gene Expression Regulation; Humans; Interleukin-2; Isoquinolines; Lymphocytes; Mitoguazone; Ornithine; Phytohemagglutinins; Piperazines; Prostaglandins E; Protein Kinase C; RNA, Messenger; Tetradecanoylphorbol Acetate; Thymidine | 1986 |
[Studies on hyperthermia by the use of a thermosensitizing drug].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; DNA Replication; Eflornithine; Humans; Hyperthermia, Induced; Mice; Mice, Inbred BALB C; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Ornithine; Stomach Neoplasms | 1986 |
Effect of polyamine limitation on DNA synthesis and development of mouse preimplantation embryos in vitro.
Topics: Animals; Blastocyst; Culture Media; DNA; Eflornithine; Embryonic Development; Female; In Vitro Techniques; Mice; Mitoguazone; Ornithine; Polyamines; Pregnancy; Spermine | 1986 |
Synergistic antileukemic effect of two polyamine synthesis inhibitors. Host survival and cell-cycle kinetic analysis.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Cycle; Drug Synergism; Eflornithine; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1986 |
Phase I study of alpha-difluoromethylornithine and methyl-GAG.
Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Antineoplastic Combined Chemotherapy Protocols; Deafness; Drug Evaluation; Eflornithine; Humans; Leukopenia; Middle Aged; Mitoguazone; Neoplasms; Ornithine; Thrombocytopenia | 1986 |
Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Eflornithine; Erythrocytes; Intestinal Mucosa; Male; Mitoguazone; Neoplasms, Experimental; Ornithine; Platelet Count; Polyamines; Rats; Rats, Inbred F344 | 1986 |
Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone).
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Eflornithine; Guanidines; Kinetics; Mitochondria; Mitoguazone; Ornithine; Putrescine; Pyruvates; Pyruvic Acid; Rats; Spermidine; Temperature; Time Factors | 1985 |
Effects of inhibitors of polyamine biosynthesis on the growth and melanogenesis of murine melanoma cells.
Topics: Animals; Cell Division; Cells, Cultured; Eflornithine; Guanidines; Melanins; Melanoma; Mice; Mitoguazone; Monophenol Monooxygenase; Ornithine; Polyamines | 1985 |
Effect of pretreatment with alpha-difluoromethylornithine on the selectivity of methylglyoxal bis(guanylhydrazone) for tumor tissue in L1210 leukemic mice.
Topics: Animals; Carbon Radioisotopes; Drug Therapy, Combination; Eflornithine; Female; Guanidines; Leukemia L1210; Mice; Mice, Inbred DBA; Mitoguazone; Ornithine | 1985 |
Antitumor effects of two polyamine antimetabolites combined with mitomycin C on human stomach cancer cells xenotransplanted into nude mice.
Topics: Adenocarcinoma, Papillary; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; DNA; Eflornithine; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Mitomycin; Mitomycins; Ornithine; Polyamines; Stomach Neoplasms | 1985 |
Ornithine decarboxylase modification and polyamine-stimulated enzyme inactivation in HTC cells.
Topics: Animals; Cell Line; Chromatography, Gel; Chromatography, Ion Exchange; Cycloheximide; Eflornithine; Isoenzymes; Mitoguazone; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Spermidine | 1985 |
Polyamines and estrogen control of growth of the NMU-induced rat mammary tumor.
Topics: Animals; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Estradiol; Estrogens; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Mitoguazone; Nitrosourea Compounds; Ornithine; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred Strains; Tamoxifen | 1985 |
Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cycloheximide; Eflornithine; Half-Life; Immunosorbent Techniques; Kinetics; Liver; Male; Mitoguazone; Molecular Weight; Ornithine; Prostate; Putrescine; Rabbits; Radioimmunoassay; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1985 |
Effect of 1,25-dihydroxyvitamin D on S-adenosylmethionine decarboxylase in chick intestine.
Topics: Adenosylmethionine Decarboxylase; Animals; Calcitriol; Calcium; Carboxy-Lyases; Chickens; Dactinomycin; Dose-Response Relationship, Drug; Duodenum; Eflornithine; Enzyme Induction; Intestinal Absorption; Intestinal Mucosa; Kinetics; Mitoguazone; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Spermine; Steroids | 1985 |
Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Cycle; Cell Survival; Cyclohexylamines; Eflornithine; Mitoguazone; Ornithine; Polyamines; Putrescine; Rats; Spermidine Synthase; Transferases | 1985 |
Prolactin stimulation of Nb 2 node lymphoma cell division is inhibited by polyamine biosynthesis inhibitors.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line; Drug Interactions; Eflornithine; Lymphoma; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prolactin; Rats | 1985 |
Regulation of epidermal proliferation in mouse epidermis by combination of difluoromethyl ornithine (DFMO) and methylglyoxal bis(guanylhydrazone) (MGBG).
Topics: Animals; DNA; Drug Combinations; Eflornithine; Epidermis; Growth; Mice; Mitoguazone; Ornithine; Polyamines; Skin | 1985 |
[Polyamines, polyamine antimetabolites and urogenital tumors. State of research and clinical results].
Topics: Adenosylmethionine Decarboxylase; Antimetabolites, Antineoplastic; Carboxy-Lyases; Drug Combinations; Eflornithine; Enzyme Induction; Enzyme Inhibitors; Humans; Kidney Neoplasms; Male; Mitoguazone; Ornithine; Polyamines; Prostatic Neoplasms; Urogenital Neoplasms | 1985 |
Pharmacokinetic approaches to drug distribution in the cerebrospinal fluid based on ventricular administration in beagle dogs.
Topics: Animals; Brain Chemistry; Dogs; Eflornithine; Half-Life; Injections, Intraventricular; Inulin; Kinetics; Male; Mitoguazone; Models, Biological; Nimustine; Nitrosourea Compounds; Ornithine; Pharmaceutical Preparations | 1985 |
Increased rate of tumor cell death caused by polyamine synthesis inhibitors.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; Cell Survival; Eflornithine; Guanidines; Male; Mice; Mice, Inbred Strains; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1984 |
Methylglyoxal BIS (guanylhydrazone) and alpha-difluoromethylornithine-induced polyamine deprivation in psoriatic lesions.
Topics: Carboxy-Lyases; Dose-Response Relationship, Drug; Eflornithine; Guanidines; Humans; Injections, Intradermal; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Psoriasis; Putrescine; Skin; Spermidine; Spermine | 1982 |
Effect of polyamine antimetabolites on cultured human keratinocytes from normal and uninvolved psoriatic skin.
Topics: Antimetabolites; Cell Division; Cells, Cultured; DNA; Eflornithine; Guanidines; Humans; Keratins; Mitoguazone; Ornithine; Protein Biosynthesis; Psoriasis; Putrescine; Skin; Spermidine; Spermine | 1984 |
Inhibitors of polyamine biosynthesis block human cytomegalovirus replication.
Topics: Antiviral Agents; Cells, Cultured; Cytomegalovirus; Eflornithine; Guanidines; Humans; Mitoguazone; Ornithine; Polyamines; Spermidine; Spermine; Virus Replication | 1982 |
Activation of ADP-ribosyltransferase in polyamine-depleted mammalian cells.
Topics: Adenosine Diphosphate Ribose; Animals; Cells, Cultured; Centrifugation, Density Gradient; Chromatography; Cricetinae; DNA; Enzyme Activation; Fibroblasts; Kidney; Mitoguazone; Nucleotidyltransferases; Ornithine; Poly(ADP-ribose) Polymerases; Spermidine; Spermine | 1984 |
Modulation of the tissue disposition of methylglyoxal bis(guanylhydrazone) in mice by polyamine depletion and by polyamine administration.
Topics: Animals; Bone Marrow; Carboxy-Lyases; Eflornithine; Guanidines; Intestine, Small; Liver; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Tissue Distribution | 1983 |
Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostate cancer.
Topics: Animals; Body Weight; Drug Therapy, Combination; Eflornithine; Guanidines; Male; Mitoguazone; Neoplasm Transplantation; Neoplasms, Experimental; Ornithine; Polyamines; Prostatic Neoplasms; Rats; Vidarabine | 1983 |
Combined use of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in normal and leukemia-bearing mice.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Drug Therapy, Combination; Eflornithine; Female; Guanidines; Leukemia L1210; Mice; Mice, Inbred DBA; Mitoguazone; Ornithine; Spleen; Time Factors; Tissue Distribution | 1983 |
Changes in mitochondrial structure and function in 9l rat brain tumor cells treated in vitro with alpha-difluoromethylornithine, a polyamine biosynthesis inhibitor.
Topics: Animals; Brain; Cells, Cultured; Eflornithine; Microscopy, Electron; Mitochondria; Mitoguazone; Ornithine; Polyamines; Pyruvates; Pyruvic Acid; Rats | 1983 |
Cytotoxicity of methylglyoxal bis(guanylhydrazone) in combination with alpha-difluoromethylornithine against HeLa cells and mouse L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Synergism; Drug Therapy, Combination; Eflornithine; Female; Guanidines; HeLa Cells; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Mitoguazone; Neoplasm Transplantation; Ornithine; Polyamines | 1983 |
Inhibition of polyamine synthesis blocks urinary secretion of beta-glucuronidase from mouse kidney.
Topics: Animals; Eflornithine; Enzyme Induction; Glucuronidase; Kidney; Male; Mice; Mitoguazone; Ornithine; Polyamines; Testosterone | 1983 |
Stimulation of melanotic expression in murine melanoma cells exposed to polyamine antimetabolites.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Drug Synergism; Eflornithine; Guanidines; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Mitoguazone; Monophenol Monooxygenase; Ornithine; Polyamines | 1983 |
Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis.
Topics: Adenocarcinoma; Animals; Eflornithine; Guanidines; Kidney; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mitoguazone; Neoplasms, Experimental; Ornithine; Polyamines | 1983 |
Inhibition of DNA and protein synthesis in UV-irradiated mouse skin by 2-difluoromethylornithine, methylglyoxal bis(guanylhydrazone), and their combination.
Topics: Animals; DNA Replication; Drug Interactions; Eflornithine; Female; Guanidines; Mice; Mitoguazone; Ornithine; Protein Biosynthesis; Putrescine; Skin; Spermidine; Ultraviolet Rays | 1983 |
Metabolic consequences of inhibition of cerebral adenosylmethionine decarboxylase by methylglyoxal bis(Guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Animals; Brain; Carboxy-Lyases; Eflornithine; Guanidines; Injections, Intraventricular; Male; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase; Polyamines | 1983 |
Role of diamine oxidase during the treatment of tumour-bearing mice with combinations of polyamine anti-metabolites.
Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Drug Therapy, Combination; Eflornithine; Female; Guanidines; Leukemia L1210; Mice; Mice, Inbred DBA; Mitoguazone; Ornithine; Polyamines | 1983 |
Sequential inhibition of polyamine synthesis. A phase I trial of DFMO (alpha-difluoromethylornithine) and methyl-GAG [methylglyoxal-bis(guanylhydrazone)].
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Drug Therapy, Combination; Eflornithine; Guanidines; Humans; Middle Aged; Mitoguazone; Neoplasms; Ornithine; Polyamines | 1983 |
Percutaneous penetration of methylglyoxal bis(guanylhydrazone): effects on hairless mouse epidermis in vivo.
Topics: Administration, Topical; Animals; DNA; Eflornithine; Guanidines; In Vitro Techniques; Mice; Mice, Hairless; Mitoguazone; Ornithine; Polyamines; Psoriasis; Skin; Skin Absorption | 1983 |
[Combined antitumor therapy with polyamine biosynthesis inhibitors and mitomycin C].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Eflornithine; Humans; Mice; Mice, Nude; Mitoguazone; Mitomycin; Mitomycins; Neoplasm Transplantation; Ornithine; Stomach Neoplasms | 1983 |
Biochemical and ultrastructural characterization of human cell variants resistant to the antiproliferative effects of methylglyoxal bis(guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Cell Cycle; Cell Line; Drug Resistance; Eflornithine; Genetic Variation; Guanidines; Humans; Kinetics; Lung; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Oxygen Consumption; Pyruvates; Pyruvic Acid | 1983 |
Potentiation of methylglyoxal-bis-guanylhydrazone by alpha-difluoromethylornithine in rat prostate cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line; Drug Synergism; Eflornithine; Guanidines; Humans; Male; Mitoguazone; Neoplasm Transplantation; Ornithine; Prostatic Neoplasms; Rats; Rats, Inbred Strains | 1984 |
Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Eflornithine; Guanidines; Male; Mitoguazone; Ornithine; Polyamines; Prostatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains; Spermidine | 1984 |
Some effects of inhibitors of polyamine synthesis on experimental prostatic cancer.
Topics: Adenine; Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Guanidines; Male; Mice; Mice, Nude; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prostatic Neoplasms; Rats; Vidarabine | 1984 |
Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites.
Topics: Animals; Cadaverine; Carcinoma, Ehrlich Tumor; Diamines; Eflornithine; Guanidines; Mice; Mitoguazone; Ornithine; Putrescine | 1984 |
[Combined therapy with polyamine biosynthesis inhibitors and mitomycin C].
Topics: Animals; DNA Replication; DNA, Neoplasm; Drug Therapy, Combination; Eflornithine; Guanidines; Humans; Mice; Mice, Nude; Mitoguazone; Mitomycin; Mitomycins; Neoplasm Transplantation; Ornithine; Stomach Neoplasms | 1984 |
Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor.
Topics: Adenocarcinoma; Animals; Body Weight; Cell Division; Drug Therapy, Combination; Eflornithine; Guanidines; Male; Mitoguazone; Ornithine; Polyamines; Prostatic Neoplasms; Rats; Rats, Inbred Strains | 1984 |
Differential effects of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the testosterone-induced growth of ventral prostate and seminal vesicles of castrated rats.
Topics: Animals; Castration; Eflornithine; Guanidines; Male; Mitoguazone; Ornithine; Polyamines; Prostate; Rats; Rats, Inbred Strains; Seminal Vesicles; Testosterone | 1984 |
Different efflux rates may determine the cellular accumulation of various bis(guanylhydrazones).
Topics: Animals; Cells, Cultured; Eflornithine; Guanidines; Leukemia L1210; Mice; Mitoguazone; Ornithine; Spermidine; Time Factors | 1984 |
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Division; Drug Synergism; Eflornithine; Guanidines; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Mitoguazone; Neoplasm Metastasis; Ornithine; Tissue Distribution | 1984 |
Glyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in tumour cells.
Topics: Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; DNA, Neoplasm; Eflornithine; Female; Guanidines; Leukemia L1210; Mice; Mitoguazone; Neoplasm Proteins; Ornithine; Polyamines | 1984 |
Potential uses of polyamine biosynthesis inhibitors in tumor therapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; DNA Repair; Drug Therapy, Combination; Eflornithine; Humans; Mitoguazone; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Sister Chromatid Exchange | 1984 |
Physiological effects in bovine lymphocytes of inhibiting polyamine synthesis with ethylglyoxal bis(guanylhydrazone).
Topics: Animals; Aphidicolin; Cattle; Cycloheximide; Diterpenes; DNA Replication; Eflornithine; Guanidines; Kinetics; Lymphocytes; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Proteins; Spermidine | 1984 |
CNS toxicity and CSF pharmacokinetics of intraventricular DFMO and MGBG in beagle dogs.
Topics: Animals; Antimetabolites, Antineoplastic; Cerebral Ventricles; Dogs; Eflornithine; Guanidines; Injections, Intraventricular; Male; Metabolic Clearance Rate; Mitoguazone; Ornithine | 1984 |
New therapeutic approaches for brain tumors.
Topics: Brachytherapy; Brain Neoplasms; Bromodeoxyuridine; Eflornithine; Humans; Hyperthermia, Induced; Iodine Radioisotopes; Mitoguazone; Ornithine; Polyamines | 1984 |
Periimplantation-like growth and development of mouse blastocysts in medium containing horse serum.
Topics: Animals; Blastocyst; Blood; Cattle; Culture Media; Embryo Implantation; Female; Fetal Blood; Horses; Mice; Mice, Inbred ICR; Mitoguazone; Ornithine; Polyamines; Spermidine; Spermine | 1984 |
Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation.
Topics: Animals; Brain Neoplasms; Cell Line; Cell Survival; Cells, Cultured; DNA; DNA, Neoplasm; Eflornithine; Guanidines; Mitoguazone; Ornithine; Polyamines; Putrescine; Radiation Tolerance; Rats; Spermidine; Spermine; X-Rays | 1980 |
Ovarian function in the rat following irreversible inhibition of L-ornithine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Estrus; Female; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Ovary; Ovulation; Pregnancy; Putrescine; Rats; Spermidine; Spermine | 1980 |
Intracellular putrescine and spermidine deprivation induces increased uptake of the natural polyamines and methylglyoxal bis(guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Mitoguazone; Ornithine; Ornithine Decarboxylase; Putrescine; Spermidine | 1980 |
Polyamine deprivation-induced enhanced uptake of methylglyoxal bis(guanylhydrazone) by tumor cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Eflornithine; Female; Guanidines; Humans; Iodoacetates; Iodoacetic Acid; Leukemia, Lymphoid; Mice; Mitoguazone; Ornithine; Putrescine; Spermine | 1981 |
Death of tumor cells in response to the use of a system of stimulated polyamine uptake from the transport of methylglyoxal bis(guanylhydrazone).
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Cell Survival; Cells, Cultured; Eflornithine; Guanidines; Mitoguazone; Ornithine; Polyamines | 1981 |
Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia.
Topics: Antineoplastic Agents; Child; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Eflornithine; Female; Guanidines; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mitoguazone; Ornithine | 1981 |
Effects of inhibitors of ornithine and S-adenosylmethionine decarboxylases on L6 myoblast proliferation.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cells, Cultured; Eflornithine; Mitoguazone; Muscles; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1982 |
Effect of epidermal polyamine depletion on the accumulation of methylglyoxal bis(guanylhydrazone) in mouse skin.
Topics: Animals; Eflornithine; Female; Guanidines; Mice; Mitoguazone; Ornithine; Polyamines; Putrescine; Skin; Skin Physiological Phenomena; Spermidine | 1982 |
Some properties of the polyamine deprivation-inducible uptake system for methylglyoxal bis(guanylhydrazone) in tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Iodoacetates; Iodoacetic Acid; Mice; Mitoguazone; Neoplasms, Experimental; Ornithine; Ouabain; Polyamines; Putrescine; Spermidine | 1981 |
Combined topical use of difluoromethyl ornithine and methylglyoxal bis (guanylhydrazone) in UV-irradiated mouse skin.
Topics: Adenosylmethionine Decarboxylase; Animals; Eflornithine; Female; Guanidines; Male; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Skin; Spermidine; Ultraviolet Rays | 1982 |
Delayed sensitization to heat by inhibitors of polyamine-biosynthetic enzymes.
Topics: Animals; Carboxy-Lyases; Cell Division; Cell Line; Cell Survival; Cricetinae; Cricetulus; Eflornithine; Female; Guanidines; Hot Temperature; Kinetics; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Ovary; Putrescine | 1982 |
[Antitumor effects of polyamine synthesis inhibitors based on major premise of treatment for human malignant tumor].
Topics: Animals; Cell Division; Drug Synergism; Drug Therapy, Combination; Eflornithine; Gastrointestinal Neoplasms; Guanidines; Mice; Mitoguazone; Neoplasms, Experimental; Ornithine; Polyamines; Stomach Neoplasms | 1982 |
Effect of inhibitors of polyamine synthesis on activation of diapausing mouse blastocysts in vitro.
Topics: Animals; Blastocyst; Carboxy-Lyases; Cells, Cultured; Culture Media; Embryo Implantation; Embryo Implantation, Delayed; Female; Guanidines; In Vitro Techniques; Mice; Mice, Inbred Strains; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
A biochemical investigation of the adenovirus-induced G1 to S phase progression: thymidine kinase, ornithine decarboxylase, and inhibitors of polyamine biosynthesis.
Topics: Adenoviruses, Human; Animals; Blood; Calcium; Carboxy-Lyases; Cells, Cultured; Cricetinae; Dactinomycin; Enzyme Induction; Fibroblasts; Genes, Viral; Humans; Interphase; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase; Polyamines; Rats; Thymidine Kinase; Time Factors | 1982 |
Inhibition of EMT6 tumor growth by interference with polyamine biosynthesis; effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Carboxy-Lyases; Cells, Cultured; Cyclophosphamide; Female; Mammary Neoplasms, Experimental; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1980 |