ornithine has been researched along with methotrexate in 29 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (41.38) | 18.7374 |
| 1990's | 9 (31.03) | 18.2507 |
| 2000's | 3 (10.34) | 29.6817 |
| 2010's | 4 (13.79) | 24.3611 |
| 2020's | 1 (3.45) | 2.80 |
| Authors | Studies |
|---|---|
| Bader, H; Forsch, RA; Freisheim, JH; Rosowsky, A | 1 |
| Franco, CT; Hsieh, P; McGuire, JJ; Piper, JR | 1 |
| Bader, H; Freisheim, JH; Moran, RG; Radike-Smith, M; Rosowsky, A; Solan, VC; Wright, JE | 1 |
| Levin, VA | 1 |
| Freisheim, JH; Kumar, AA | 1 |
| Delcamp, TJ; Freisheim, JH; Kumar, AA; Price, EM; Smith, PL; Susten, SS | 1 |
| Baccanari, DP; Delcamp, TJ; Forsch, RA; Freisheim, JH; Rosowsky, A; Solan, VC | 1 |
| Bolanowska, WE; McGuire, JJ; Piper, JR | 1 |
| Bader, H; Cucchi, CA; Freisheim, JH; Kohler, W; Moran, RG; Rosowsky, A | 1 |
| Bader, H; Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A; Solan, VC | 1 |
| Russell, DH | 1 |
| Anstead, GM; Freisheim, JH; Kempton, RJ; Kumar, AA; Price, EM | 1 |
| Alhonen-Hongisto, L; Deen, DF; Hung, DT; Marton, LJ | 1 |
| Chen, G; Rosowsky, A; Wright, JE | 1 |
| Galivan, J; Rhee, MS; Rosowsky, A; Wright, JE | 1 |
| Holden, SA; Northey, D; Robinson, MF; Rosowsky, A; Teicher, BA | 1 |
| Bader, H; Keyomarsi, K; Matherly, LH; Rosowsky, A; Wright, JE | 1 |
| Bader, H; Rosowsky, A; Teicher, BA; Vaidya, CM; Wright, JE | 1 |
| Johnson, JM; Meiering, EM; Pardo, J; Rosowsky, A; Wagner, G; Wright, JE | 1 |
| Kato, N; Matsuoka, H; Mihara, M; Miyamoto, K; Ohi, N; Takeda, Y | 1 |
| Alperin, WL; Pardo, M; Rosowsky, A; Tretyakov, A; Trites, D; Wright, JE | 1 |
| Chen, Y; Rosowsky, A; Vaidya, CM; Wright, JE | 1 |
| Assaraf, YG; Bunni, MA; Drori, S; Jansen, G; Kathmann, I; Mauritz, R; Noordhuis, P; Peters, GJ; Pinedo, HM; Priest, DG; Rosowsky, A; Schornagel, JH | 1 |
| Assaraf, YG; Ifergan, I; Jansen, G; Kaufman, Y; Rothem, L | 1 |
| Kumar, M; Subba Rao, G; Vijayakrishnan, R | 1 |
| Adamson, PC; Norris, RE | 1 |
| Hara, S; Jimi, S; Matsumoto, T; Takamatsu, Y; Tamura, K; Uchiyama, M | 1 |
| Assaraf, YG; Dijkmans, BA; Gerards, AH; Jansen, G; Lems, WF; Oerlemans, R; Scheper, RJ; van der Heijden, JW | 1 |
| Frühauf, J; Gangjee, A; Hou, Z; Matherly, LH; Ning, C; O'Connor, C; Tong, N; Wallace-Povirk, A | 1 |
1 review(s) available for ornithine and methotrexate
| Article | Year |
|---|---|
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Eflornithine; Ependymoma; Fluorouracil; Glioblastoma; Humans; Hydroxyurea; Lomustine; Medulloblastoma; Methotrexate; Mitoguazone; Mitolactol; Neoplasm Recurrence, Local; Ornithine; Prednisone; Risk; Thioguanine; Vincristine | 1985 |
28 other study(ies) available for ornithine and methotrexate
| Article | Year |
|---|---|
Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
Topics: Aminopterin; Antineoplastic Agents; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Structure; Ornithine; Spectrophotometry; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1991 |
Folylpolyglutamate synthetase inhibition and cytotoxic effects of methotrexate analogs containing 2,omega-diaminoalkanoic acids.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Cell Line; Folic Acid Antagonists; Humans; Leukemia; Liver; Methotrexate; Ornithine; Peptide Synthases; Polyglutamic Acid; Rabbits; Rats; Structure-Activity Relationship | 1986 |
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
Topics: Aminobutyrates; Aminopterin; Animals; beta-Alanine; Cell Division; Folic Acid Antagonists; Glutamates; Glutamic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Molecular Weight; Ornithine; Peptide Synthases | 1986 |
Separation of methotrexate analogs containing terminal lysine or ornithine and their dansyl derivatives by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Lysine; Methotrexate; Ornithine; Structure-Activity Relationship | 1986 |
Analogues of folate antagonists as affinity and fluorescent probes of dihydrofolate reductase structure and function.
Topics: Affinity Labels; Animals; Folic Acid; Leukemia L1210; Lysine; Methotrexate; Mice; Ornithine; Tetrahydrofolate Dehydrogenase; X-Ray Diffraction | 1986 |
Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.
Topics: Acetates; Animals; Candida albicans; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Isoxazoles; Leukemia L1210; Lysine; Methotrexate; Mice; NADP; Ornithine; Protein Conformation; Spectrophotometry | 1987 |
Structural specificity of inhibition of human folylpolyglutamate synthetase by ornithine-containing folate analogs.
Topics: Aldehyde Oxidase; Aldehyde Oxidoreductases; Animals; Folic Acid; Humans; Leukemia, Experimental; Methotrexate; Ornithine; Peptide Synthases; Rabbits; Structure-Activity Relationship; Tumor Cells, Cultured | 1988 |
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
Topics: Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Ornithine; Peptide Synthases; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 1988 |
Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
Topics: Aminobutyrates; Aminopterin; Animals; Cell Division; Folic Acid Antagonists; Growth Inhibitors; Leukemia L1210; Liver; Methotrexate; Mice; Ornithine; Peptide Synthases; Structure-Activity Relationship | 1987 |
Effects of methotrexate and cytosine arabinoside on polyamine metabolism in a mouse L1210 leukemia.
Topics: Animals; Carbon Isotopes; Carboxy-Lyases; Cytarabine; Leukemia L1210; Methotrexate; Mice; Mice, Inbred Strains; Ornithine; Polyamines; Putrescine; Spermidine; Spermine; Spleen | 1972 |
High-performance liquid chromatography of methotrexate analogs containing terminal lysine or ornithine and their dansyl derivatives.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Fluorescence; Glutamates; Lysine; Methotrexate; Ornithine | 1983 |
Decreased cell kill of vincristine and methotrexate against 9L rat brain tumor cells in vitro caused by alpha-difluoromethylornithine-induced polyamine depletion.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; Eflornithine; Kinetics; Methotrexate; Mitotic Index; Ornithine; Polyamines; Rats; Vincristine | 1984 |
Dihydrofolate reductase binding and cellular uptake of nonpolyglutamatable antifolates: correlates of cytotoxicity toward methotrexate-sensitive and -resistant human head and neck squamous carcinoma cells.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Kinetics; Methotrexate; Ornithine; Pterins; Pteroylpolyglutamic Acids; Quinazolines; Tetrahydrofolate Dehydrogenase; Tritium; Tumor Cells, Cultured | 1995 |
Biochemical studies on PT523, a potent nonpolyglutamatable antifolate, in cultured cells.
Topics: Animals; Biological Transport; DNA, Neoplasm; Folic Acid; Folic Acid Antagonists; Growth Inhibitors; In Vitro Techniques; Liver Neoplasms, Experimental; Methotrexate; Ornithine; Polyglutamic Acid; Pterins; Rats; Tumor Cells, Cultured | 1994 |
Antifolates can potentiate topoisomerase II inhibitors in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cell Survival; DNA Damage; DNA, Neoplasm; Drug Synergism; Etoposide; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Male; Methotrexate; Mice; Mice, Inbred C3H; Novobiocin; Ornithine; Pterins; Topoisomerase II Inhibitors; Trimetrexate; Tumor Cells, Cultured | 1995 |
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Folic Acid Antagonists; Humans; Methotrexate; Mice; Ornithine; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Analogues of N alpha-(4-amino-4-deoxypteroyl)-N delta-hemiphthaloyl-L-ornithine (PT523) modified in the side chain: synthesis and biological evaluation.
Topics: Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Glutamates; Humans; Magnetic Resonance Spectroscopy; Methotrexate; Mice; Molecular Structure; Ornithine; Pterins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1997 |
NMR solution structure of the antitumor compound PT523 and NADPH in the ternary complex with human dihydrofolate reductase.
Topics: Antineoplastic Agents; Binding Sites; Crystallography, X-Ray; Folic Acid Antagonists; Humans; Kinetics; Ligands; Magnetic Resonance Spectroscopy; Methotrexate; NADP; Ornithine; Protein Conformation; Pterins; Tetrahydrofolate Dehydrogenase | 1997 |
Antirheumatic agents. III. Novel methotrexate derivatives bearing an indoline ring and a modified ornithine or glutamic acid.
Topics: Antirheumatic Agents; Cell Division; Glutamic Acid; Humans; Indoles; Leukocytes, Mononuclear; Methotrexate; Ornithine; Structure-Activity Relationship | 1997 |
Pharmacokinetics, antifolate activity and tissue distribution of PT523 in SCC VII tumor-bearing mice.
Topics: Animals; Antineoplastic Agents; Area Under Curve; Carbon Radioisotopes; Carcinoma, Squamous Cell; Folic Acid Antagonists; Injections, Intravenous; Isotope Labeling; Male; Methotrexate; Mice; Mice, Inbred C3H; Neoplasms, Experimental; Ornithine; Pterins; Tetrahydrofolates; Tissue Distribution | 1998 |
Efficient utilization of the reduced folate carrier in CCRF-CEM human leukemic lymphoblasts by the potent antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L- ornithine (PT523) and its B-ring analogues.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Biological Transport; Carrier Proteins; Drug Interactions; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Leukemia; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Ornithine; Pterins; Reduced Folate Carrier Protein; Tumor Cells, Cultured | 2000 |
Multiple mechanisms of resistance to methotrexate and novel antifolates in human CCRF-CEM leukemia cells and their implications for folate homeostasis.
Topics: Biological Transport; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Glutamates; Guanine; Homeostasis; Humans; Leukemia; Methotrexate; Ornithine; Pemetrexed; Peptide Synthases; Polyglutamic Acid; Pterins; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase; Tumor Cells, Cultured | 2002 |
Coexistence of multiple mechanisms of PT523 resistance in human leukemia cells harboring 3 reduced folate carrier alleles: transcriptional silencing, inactivating mutations, and allele loss.
Topics: Alleles; Biological Transport; Cell Line, Tumor; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Gene Silencing; Humans; Leukemia; Loss of Heterozygosity; Membrane Transport Proteins; Methotrexate; Ornithine; Pterins; Reduced Folate Carrier Protein; Response Elements; Tetrahydrofolate Dehydrogenase; Transcription Factors | 2006 |
In silico structure-based design of a novel class of potent and selective small peptide inhibitor of Mycobacterium tuberculosis Dihydrofolate reductase, a potential target for anti-TB drug discovery.
Topics: Amino Acid Sequence; Antitubercular Agents; Binding Sites; Computational Biology; Crystallography, X-Ray; Drug Design; Folic Acid Antagonists; Humans; Hydrogen Bonding; Ligands; Methotrexate; Microbial Sensitivity Tests; Molecular Dynamics Simulation; Molecular Sequence Data; Mycobacterium tuberculosis; Ornithine; Peptides; Pterins; Reproducibility of Results; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Triazines; Tuberculosis | 2010 |
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias.
Topics: Aminopterin; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Jurkat Cells; Leukemia; Lymphoma; Methotrexate; Molecular Structure; Ornithine; Pemetrexed; Pterins | 2010 |
Simple and sensitive HPLC method for the fluorometric determination of methotrexate and its major metabolites in human plasma by post-column photochemical reaction.
Topics: Aged; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Humans; Limit of Detection; Linear Models; Lymphoma, Large B-Cell, Diffuse; Male; Methotrexate; Ornithine; Photolysis; Reproducibility of Results; Spectrometry, Fluorescence | 2012 |
Methotrexate analogues display enhanced inhibition of TNF-α production in whole blood from RA patients.
Topics: Antirheumatic Agents; Arthritis, Rheumatoid; Female; Folic Acid Antagonists; Humans; Male; Methotrexate; Middle Aged; Ornithine; Pterins; Quinazolines; T-Lymphocytes; Thiophenes; Trimetrexate; Tumor Necrosis Factor-alpha | 2014 |
Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.
Topics: Biological Transport; Cell Proliferation; Folate Receptor 1; Folic Acid; Folic Acid Antagonists; HeLa Cells; Humans; Methotrexate; Neoplasms; Ornithine; Pemetrexed; Proton-Coupled Folate Transporter; Pterins; Reduced Folate Carrier Protein | 2021 |