ornithine has been researched along with eflornithine in 485 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 450 (92.78) | 18.7374 |
| 1990's | 22 (4.54) | 18.2507 |
| 2000's | 8 (1.65) | 29.6817 |
| 2010's | 5 (1.03) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hacker, AD | 1 |
| Alunda, JM; Balaña-Fouce, R; Escribano, MI | 1 |
| Ajani, JA; Grossie, VB; Nishioka, K; Ota, DM | 1 |
| Byus, CV; Wu, VS | 1 |
| Lucas, RC; Seidenfeld, J; Stern, PH | 1 |
| Kovacs, JA; Lipschik, GY; Masur, H | 1 |
| Dembinski, AB; Johnson, LR; Seidel, ER; Tabata, K | 1 |
| Newberne, PM; Sondergaard, D; Taylor, F | 1 |
| Fujita, T; Koizumi, T; Matsui, T; Nakagawa, T; Nakao, Y; Watanabe, S | 1 |
| Dunzendorfer, U; Knöner, M | 1 |
| Bell, JM; Slotkin, TA; Whitmore, WL | 1 |
| Abu-Khalaf, M; Diekema, KA; Kingsnorth, AN; LaMuraglia, GM; Malt, RA; McCann, PP; Ross, JS | 1 |
| Egyházi, E; Emanuelsson, H; Heby, O; Långström, E; Löwkvist, B; Sjöberg, J | 1 |
| Bondy, SC; Emerich, D; Tilson, HA | 1 |
| Alhonen, L; Eloranta, T; Hirvonen, A; Hyvönen, T; Jänne, J | 1 |
| Ajani, JA; Chang, TH; Grossie, VB; Nishioka, K; Ota, DM; Patenia, D | 1 |
| Bolkenius, FN; Daune, G; Knödgen, B; Seiler, N | 1 |
| Blachier, F; Leclercq-Meyer, V; Malaisse, WJ; Marchand, J; Mathias, PC; Sener, A; Woussen-Colle, MC | 1 |
| Daune, G; Gerhart, F; Grauffel, C; Seiler, N | 1 |
| Ascioti, C; Audino, MG; De Sarro, A; De Sarro, GB; Libri, V; Nisticò, G | 1 |
| Krieger, NS; Lucas, RC; Seidenfeld, J; Stern, PH | 1 |
| Cruz, NF; Dienel, GA; Rosenfeld, SJ | 1 |
| Brown, ND; Whaun, JM | 1 |
| Tyms, AS | 3 |
| Ekker, M; Sourkes, TL | 1 |
| Dascombe, MJ; Haegele, KD | 1 |
| Bartolome, JV; Davis, JN; Gauger, LL; Jones, LS; Slotkin, TA | 1 |
| Agnati, LF; Calza, L; Corti, A; Davalli, P; Fuxe, K; Goldstein, M; Piccinini, G; Toffano, G; Zini, I; Zoli, M | 1 |
| Erecińska, M; Pastuszko, A; Wilson, DF | 1 |
| Bondy, SC; Walker, CH | 1 |
| Delongchamp, RR; Harmon, JR; Kimmel, GL; Webb, PJ | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Kawata, S; Miyazaki, M; Ohta, M; Shimura, T; Shrestha, RD; Sugasawa, H; Takahashi, O | 3 |
| Endoh, F; Fujimoto, S; Igarashi, K; Miyazaki, M; Ohta, M; Okui, K; Shrestha, RD; Togawa, Y | 1 |
| Kerrigan, D; Marton, LJ; Zwelling, LA | 1 |
| Alhonen-Hongisto, L; Jänne, J; Jänne, OA; Kallio, A; Kontula, KK; Seppänen, P; Sinervirta, R | 1 |
| Bachrach, U; Shtorch, A | 1 |
| Hollingdale, MR; McCann, PP; Sjoerdsma, A | 1 |
| Laveck, MA; Lechner, JF; McClendon, IA; Willey, JC | 1 |
| Alhonen-Hongisto, L; Gahmberg, CG; Jänne, J; Jänne, OA; Kallio, A; Sinervirta, R | 1 |
| Blume, GB; Goldstone, AD; Koenig, H | 1 |
| Levin, VA | 1 |
| Baylin, SB; Casero, RA; Luk, GD; Nelkin, BD | 1 |
| Baylin, SB; Luk, GD | 2 |
| Abeloff, MD; Baylin, SB; Luk, GD; McCann, PP; Sjoerdsma, A | 1 |
| Cope, FO | 1 |
| Clark, RS; McGovern, KA; Pegg, AE | 1 |
| Abeloff, MD; Baylin, SB; Luk, GD; Rosen, ST; Sjoerdsma, A; Zeltzman, M | 1 |
| Dorr, RT; Gerner, EW; Liddil, JD | 1 |
| Block, AL; Komar, KA; Naujokas, MF; Seidenfeld, J | 3 |
| Meilhoc, E; Moutin, MJ; Osborne, HB; Romani, BH | 1 |
| Bregman, MD; Meyskens, FL | 1 |
| Bey, P; Danzin, C; Gerhart, F; Kolb, M; Mamont, PS; Sjoerdsma, A | 1 |
| Bitonti, AJ; McCann, PP; Sjoerdsma, A | 2 |
| Bacchi, CJ; Bitonti, AJ; McCann, PP; Sjoerdsma, A | 2 |
| Ducore, JM; McNamara, L | 1 |
| Kramer, DL; Pera, PJ; Porter, CW; Sufrin, JR | 1 |
| Hiatt, AC; Malmberg, RL; McIndoo, J | 1 |
| Członkowska, M; Guszkiewicz, A; Zwierzchowski, L | 1 |
| Baranao, L; Demers, L; Feil, P; Garcia, M; Manni, A; Rochefort, H; Wright, C | 1 |
| Caldarera, CM; Flamigni, F; Guarnieri, C | 1 |
| Ask, A; Heby, O; Oredsson, SM; Persson, L | 1 |
| Dircks, L; Grens, A; Scheffler, IE; Slezynger, TC | 1 |
| Kingsnorth, AN | 1 |
| Gerner, EW; Mamont, PS | 1 |
| Romijn, JC; Splinter, TA | 1 |
| Wells, MR | 1 |
| Assaraf, YG; Bachrach, U; Golenser, J; Spira, DT | 2 |
| Boldizsár, M; Holczinger, L; Kremmer, T | 1 |
| Luk, GD | 1 |
| Morris, G; Nadler, JV; Slotkin, TA | 1 |
| Bourdel, G; Champigny, O; Hitier, Y | 1 |
| Seidenfeld, J; Williams-Ashman, HG | 1 |
| Bartolome, JV; Casseday, JH; McCann, PP; Schweitzer, L; Sjoerdsma, A | 1 |
| Ehrke, MJ; Eppolito, C; Mihich, E; Porter, CW | 1 |
| Meeker, LD; Ritacco, KA; Ronan, AM; Thompson, HJ | 1 |
| Inaba, M; Ishimura, E; Matsui-Yuasa, I; Morii, H; Morisada, S; Morisawa, S; Nishizawa, Y; Otani, S; Yukioka, K; Yukioka, M | 1 |
| Marshall, K; Senior, J | 1 |
| Dembinski, TC; Leung, CK; Lima, G; Shiu, RP | 1 |
| Bepler, G; Carney, DN; Gazdar, AF; Minna, JD; Nau, MM | 1 |
| Allen, ED; Natale, RB | 1 |
| Ali, M; Duvick, L; Verma, AK | 1 |
| Green, CD; Hoggard, N | 1 |
| Bowlin, TL; Davis, GF; McKown, BJ; Rosenberger, AL; Sunkara, PS | 1 |
| Heby, O; Kanje, M; Mamont, PS; Oredsson, SM; Wagner, J | 1 |
| Barbarash, RA; Sahn, SA; Toll, L | 1 |
| Erickson, D; Verma, AK | 1 |
| Pegg, AE | 3 |
| Elsholtz, HP; Friesen, HG; Shiu, RP | 1 |
| Diachok, FI; Gridina, NIa; Khomenko, AK; Kudriavets, IuI; Semeniĭ, VIa | 1 |
| Bouclier, M; Courdi, A; Lalanne, CM; Milano, G | 1 |
| Chang, ZF; Chen, KY | 1 |
| Fujisawa, H; Kitani, T | 1 |
| Ajani, JA; Grossie, VB; Nishioka, K; Ota, DM; Stephens, LC | 1 |
| Bacchi, CJ; Bitonti, AJ; Giffin, BF; McCann, PP | 1 |
| Bremner, AF; Coombs, GH; Lockwood, BC; North, MJ | 1 |
| Johnson, LR; Tabata, K | 1 |
| Berger, FG; Porter, CW | 1 |
| Coward, JK; Pegg, AE; Secrist, JA; Talekar, RR | 1 |
| Benjamin, R; Gutterman, J; Kantarjian, H; Plager, C; Quesada, J; Talpaz, M | 1 |
| Matsui-Yuasa, I; Mimura, Y; Morisawa, S; Otani, S | 1 |
| Kadofuku, T; Sato, T; Shinki, T; Suda, T | 1 |
| Herbst, EJ; Meeker, LD; Thompson, HJ | 1 |
| Bacchi, CJ; Giffin, BF; McCann, PP | 1 |
| Gerner, EW; Glass, JR | 1 |
| Garrett, JL; Van Gend, M; Ward, LC | 1 |
| Hicks, JJ; Méndez, JD; Wong, C; Yáñez, R | 1 |
| Phillips, MA; Wang, CC | 1 |
| Eloranta, TO; Hyvönen, T; Pajula, RL; Smith, TK | 1 |
| Gaget, C; Heintzelmann, B; Wagner, J; Wolf, E | 1 |
| Abe, Y; Ido, T; Ishiwata, K; Matsuzawa, T | 1 |
| Tabor, CW; Tabor, H | 1 |
| Algranati, ID; de Lustig, ES; Klein, S; Miret, JJ | 1 |
| Jetten, AM; Shirley, JE | 2 |
| Kelly, M; McCann, PP; Schindler, J | 3 |
| Alhonen-Hongisto, L; Levin, VA; Marton, LJ | 1 |
| Homma, Y; Numata, I; Oyasu, R; Ozono, S; Seidenfeld, J | 2 |
| Kovach, JS; Svingen, PA | 1 |
| Kufe, DW; Shafman, T; Watanabe, T | 1 |
| Ogawa, M | 1 |
| Andersson, LC; Karvonen, E; Pösö, H | 1 |
| Herbst, EJ; Meeker, LD; Minocha, R; Ronan, AM; Thompson, HJ | 1 |
| Fujita, K; Hayashi, S; Kameji, T; Murakami, Y | 1 |
| Jänne, J; Käpyaho, K; Sinervirta, R | 1 |
| Bianchi, M; Donati, MB; Ghezzi, P; Poggi, A; Salmona, M; Vicenzi, E | 1 |
| Bergeron, RJ; Cavanaugh, PF; Ganis, B; Kelly, E; Porter, CW; Stolowich, N | 1 |
| Komar, KA; Seidenfeld, J | 1 |
| Lima, G; Shiu, RP | 1 |
| Kramer, DL; Paul, B; Porter, CW | 1 |
| Bolkenius, FN; Seiler, N | 1 |
| Prakash, NJ; Sjoerdsma, A; Sunkara, PS | 1 |
| Fujimoto, S; Igarashi, K; Miyazaki, M; Okui, K; Shrestha, RD | 1 |
| Alitalo, K; Hölttä, E; Jänne, OA; Knuutila, S; Pohjanpelto, P | 1 |
| Ajani, JA; Chang, T; Grossie, VB; Harris, WB; Nishioka, K; Ota, DM; Patenia, D | 1 |
| Bartolome, JV; Nadler, JV; Schweitzer, L; Slotkin, TA | 1 |
| Dowling, RH; Hosomi, M; Levan, H; Lirussi, F; Miazza, B; Murphy, GM; Stace, NH | 1 |
| Bernardi, M; Bertolini, A; Botticelli, A; Genedani, S | 1 |
| Franzen, MA; Mitchell, JL; Qasba, P; Stofko, RE | 1 |
| Covey, DF; Fair, WR; Heston, WD; Uy, L | 1 |
| Manni, A; Pontari, M; Wright, C | 1 |
| Carson, DA; Kajander, EO; Kubota, M | 1 |
| Pegg, AE; Shirahata, A | 1 |
| Königk, E; Putfarken, B | 2 |
| Lawson, DE; Steeves, RM | 1 |
| Deen, DF; Feuerstein, BG; Marton, LJ | 1 |
| Chang, CC; Lachmann, PJ; Prakash, NJ; Sunkara, PS | 1 |
| Harvey, HA; Leitzel, KE; Lipton, A; Pegg, AE; Wolf, LM | 1 |
| Bander, NH; Bauer, WC; Fair, WR; Fleischmann, J; Heston, WD; Janney, C; Ratliff, TL | 1 |
| Anehus, S; Heby, O; Oredsson, SM; Persson, L | 1 |
| Gee, E; Ryan, SJ; Wong, CG | 1 |
| Hölttä, E; Hovi, T | 1 |
| Billgren, M; Heby, O; Oredsson, SM | 1 |
| Lozano, JA; Peñafiel, R; Solano, F; Solano, ME | 1 |
| Araujo, FG; Guptill, DR; Hofflin, JM; Remington, JS | 1 |
| Chandler, MD; McCandless, DW; Sears, ES | 1 |
| Galston, AW; Rajam, MV; Weinstein, LH | 1 |
| Lawson, DM; Ofenstein, JP; Rillema, JA | 1 |
| Dowling, RH; Miazza, BM | 1 |
| Altiere, RJ; Atkinson, JE; Gillespie, MN; Hacker, AD; Olson, JW | 1 |
| Georgatsos, JG; Kyriakidis, DA; Sklaviadis, TK | 1 |
| Loprinzi, CL; Verma, AK | 1 |
| Seidenfeld, J | 1 |
| Catterall, JR; Potasman, I; Remington, JS | 1 |
| Griffin, JD; Kufe, DW; Larcom, P | 1 |
| Benrezzak, O; Morisset, J | 3 |
| Bowlin, TL; Rosenberger, AL; Sunkara, PS | 1 |
| Estey, E; Freireich, EJ; Keating, MJ; Maddox, AM; McCredie, KE | 1 |
| Kahana, C; Nathans, D | 1 |
| Anehus, S; Heby, O; Linden, M; Oredsson, SM | 1 |
| Jenkins, JJ; Klein, J; McCullough, JL; Peckham, P; Weinstein, GD | 1 |
| Dunzendorfer, U | 3 |
| Gurpide, E; Holinka, CF | 1 |
| Altiere, RJ; Dyer, KK; Gillespie, MN; O'Connor, WN; Olson, JW | 1 |
| Cushion, MT; Linke, MJ; Stanforth, D; Walzer, PD | 1 |
| Landahl, HD; Levin, VA | 1 |
| Hahn, DA; Heston, WD; Kadmon, D; Mahle, C | 1 |
| Alhonen-Hongisto, L; Jänne, J; Jänne, OA; Sinervirta, R | 1 |
| Boné, G; Burke, J; Declercq, J; Schechter, PJ; Sjoerdsma, A; Van Nieuwenhove, S | 1 |
| Heby, O | 2 |
| Kingsnorth, AN; Lacaine, F; Lamuraglia, GM; Malt, RA; Ross, JS | 1 |
| Bourgeade, A; Faugere, B; Nosny, Y; Pene, P | 1 |
| Bernardi, M; Bertolini, A; Genedani, S | 1 |
| Barnes, GA; Bartolome, J; Grignolo, A; Lerea, L; Seidler, FJ; Slotkin, TA; Trepanier, PA; Weigel, SJ; Whitmore, WL | 1 |
| Delcros, JG; Quash, G; Roch, AM | 1 |
| Ito, N; Mera, Y; Moore, MA; Ogiso, T; Tsuda, H | 1 |
| Heby, O; Linden, M; Oredsson, SM | 1 |
| Chandar, N; Nagarajan, B | 1 |
| Amole, BO; Bacchi, CJ; Clarkson, AB; Hutner, SH; McCann, PP; Nathan, HC; Seed, JR; Sjoerdsma, A | 1 |
| Claverie, N; Danzin, C; Grove, J; Koch-Weser, J; Wagner, J | 1 |
| Jänne, J; Käpyaho, K; Kousa, M; Lauharanta, J; Linnamaa, K; Mustakallio, K | 1 |
| Giri, SN; Hyde, DM; Schwartz, LW; Younker, WR | 1 |
| Bacchi, CJ; Hutner, SH; McCann, PP; Nathan, HC; Sjoerdsma, A | 2 |
| Mayer, GD; Prakash, NJ; Sjoerdsma, A; Sunkara, PS | 1 |
| Marcelo, CL; Rhodes, LM; Roseeuw, DI; Voorhees, JJ | 1 |
| Bacchi, CJ; Chunosoff, L; Diekema, KA; Garofalo, J; Hutner, SH; McCann, PP; Mockenhaupt, D; Mullaney, EA; Nathan, HC; Pegg, AE; Sjoerdsma, A | 1 |
| Bacchi, CJ; Clarkson, AB; McCann, PP; Mellow, GH; Nathan, HC; Sjoerdsma, A | 1 |
| Frost, SB; Raisfeld-Danse, IH; Rakieten, N | 1 |
| Jänne, J; Käpyaho, K; Kariniemi, AL; Virtanen, I | 1 |
| Bartolome, J; Persons, D; Slepetis, RJ; Slotkin, TA; Taylor, D | 1 |
| Roth-Schechter, BF; Sarhan, S; Seiler, N | 1 |
| Bartolome, JV; Chait, EA; Slotkin, TA; Trepanier, PA | 1 |
| Baylin, SB; Collector, MI; Luk, GD; McCann, PP; Sensenbrenner, LL; Sharkis, SJ | 1 |
| Burchenal, JH; Warrell, RP | 1 |
| Ashendel, CL; Boutwell, RK; Takigawa, M; Verma, AK | 1 |
| Franze-Fernández, MT; Haim-Muchnik, L; Iapalucci-Espinoza, S; Robetto, E | 1 |
| Mäntyjärvi, R; Raina, A; Tuomi, K | 3 |
| Baylin, SB; Goodwin, G; Luk, GD; Marton, LJ | 1 |
| Hölttä, E; Hovi, T; Jänne, J; Vaheri, A; Vartio, T | 1 |
| Chambaz, EM; Duperray, A; Madani, C | 1 |
| Tyms, AS; Williamson, JD | 1 |
| Coffino, P; Marton, LJ; McConlogue, LC | 1 |
| Chen, KY; Liu, AY; Nau, D | 1 |
| Diekema, KA; Kingsnorth, AN; Malt, RA; McCann, PP; Ross, JS | 1 |
| Algranati, ID; Goldemberg, SH; Medrano, EE | 1 |
| Fields, A; Gibson, W; Irmiere, A; LaFemina, R; van Breemen, R | 1 |
| Fout, GS; Mapoles, JE; Medappa, KC; Rueckert, RR | 1 |
| Gillin, FD; McCann, PP; Reiner, DS | 1 |
| Alhonen-Hongisto, L; Jänne, J; Kallio, A; Seppänen, P | 1 |
| Pegg, AE; Seely, JE | 1 |
| Balis, ME; Dunzendorfer, U; Kleinert, E; Relyea, NM; Whitmore, WF | 1 |
| Alhonen-Hongisto, L; Jänne, J; Seppänen, P | 4 |
| Manni, A; Wright, C | 2 |
| Emanuelsson, H; Heby, O; Löwkvist, B | 2 |
| Friend, DS; Marton, LJ; Oredsson, SM | 1 |
| Russell, DH | 1 |
| Bjerkvig, R; Deen, DF; Linden, M; Marton, LJ; Oredsson, SM | 1 |
| Kallio, A; Lyda, S; McCann, PP; Niskanen, EO; Pou, G; Thornhill, A | 1 |
| Chang, CC; Prakash, NJ; Sjoerdsma, A; Sunkara, PS | 1 |
| Chaney, JE; Digenis, GA; Goto, R; Kobayashi, K | 1 |
| Bartholeyns, J | 2 |
| Lin, T; Murono, EP; Nankin, HR; Osterman, J | 1 |
| Laitinen, SI; Pajunen, AE | 1 |
| Deen, DF; Gray, JW; Marton, LJ; Oredsson, SM | 1 |
| Diekema, KA; King, WW; Kingsnorth, AN; Malt, RA; McCann, PP; Ross, JS | 1 |
| Prakash, NJ; Sunkara, PS | 1 |
| Jänne, J; Käpyaho, K | 1 |
| Deen, DF; Feuerstein, BG; Marton, LJ; Oredsson, SM; Rosenblum, ML; Tofilon, PJ | 1 |
| Boutwell, RK; Simsiman, RC; Takigawa, M; Verma, AK | 2 |
| Byrd, DJ; Csejtey, J; Levin, VA | 1 |
| Coffino, P; McConlogue, L | 2 |
| Deen, DF; Hung, DT; Marton, LJ; Shafer, RH | 1 |
| Dunzendorfer, U; Kleinert, E; Whitmore, WF | 1 |
| Hölttä, E; Pohjanpelto, P | 1 |
| Diekema, KA; Kingsnorth, AN; Malt, RA; McCann, PP; Russell, WE | 1 |
| Abeloff, MD; Baylin, SB; Griffin, CA; Luk, GD | 1 |
| Jänne, J; Käpyaho, K; Lauharanta, J | 2 |
| Hietala, OA; Laitinen, PH; Lapinjoki, SP; Pajunen, AE; Pulkka, AE | 1 |
| Abeloff, MD; Baylin, SB; Luk, GD; McCann, PP; Sharkis, SJ; Sjoerdsma, A | 1 |
| Jänne, J; Kallio, A | 1 |
| Deen, DF; Marton, LJ; Oredsson, SM | 2 |
| Chang, CC; Prakash, NJ; Sunkara, PS | 1 |
| Erwin, BG; Ewton, DZ; Florini, JR; Pegg, AE | 2 |
| Pegg, AE; Pösö, H | 2 |
| Boné, G; Charlier, J; Gillet, JM; Mulamba, PL | 1 |
| Pegg, AE; Seely, JE; Zagon, IS | 1 |
| Pegg, AE; Pösö, H; Seely, JE | 4 |
| Bacchi, CJ; Hanson, WL; Hutner, SH; McCann, PP; Nathan, HC; Sjoerdsma, A | 1 |
| Fozard, JR; Part, ML | 1 |
| Burchenal, JH; Coonley, CJ; Warrell, RP | 1 |
| Diaz-Flores, M; Durán, G; Hicks, JJ; Méndez, JD | 1 |
| Choi, JH; Scheffler, IE | 1 |
| Jenkins, JJ; McCullough, JL; Rosenblum, MG; Weinstein, GD | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Miyazaki, M; Ohyama, Y; Okui, K; Shimura, T; Shrestha, RD; Sugasawa, H; Takahashi, O | 1 |
| Kramer, DL; Porter, CW; Wiseman, A; Zychlinski, L | 1 |
| Colombo, G; Galliani, G; Luzzani, F | 2 |
| Diekema, KA; Gibson, JP; Loudy, DE; McCann, PP; Sprinkle, DJ; Yarrington, JT | 1 |
| Belleville, F; Brossat, B; Metz, R; Nabet, P; Straczek, J | 1 |
| Deen, DF; Marton, LJ; Tofilon, PJ | 1 |
| Goldstone, AD; Koenig, H; Lu, CY | 1 |
| Alhonen-Hongisto, L; Deen, DF; Marton, LJ | 2 |
| Herr, HW; Kleinert, EL; Relyea, NM; Whitmore, WF | 1 |
| Deen, DF; Marton, LJ; Oredsson, SM; Sano, Y | 1 |
| Covey, DF; Fair, WR; Heston, WD; Kadmon, D | 1 |
| Herlyn, M; O'Brien, TG; Pegg, AE; Persson, L; Ponsell, K; Seely, JE | 1 |
| Schechter, PJ; Sjoerdsma, A | 1 |
| Cruz, NF; Dienel, GA | 1 |
| Abeloff, MD; Baylin, SB; Blanc, O; Griffin, CA; Hermann, J; Luk, GD; Sjoerdsma, A; Slavik, M | 1 |
| Bethell, DR; Erwin, BG; Pegg, AE | 1 |
| Balis, ME; Dunzendorfer, U; Fogh, J; Releyea, N; Whitmore, WF | 1 |
| Kufe, D; Shafman, T; Sugiura, M | 1 |
| Hoeksema, GW; McLaughlin, PJ; Pegg, AE; Seely, JE; Zagon, IS | 1 |
| de Gee, AL; Mansfield, JM; McCann, PP | 1 |
| Bartolome, JV | 1 |
| Nishioka, K; Prakash, NJ; Sunkara, PS | 1 |
| Mamont, PS; Rudkin, BB; Seiler, N | 1 |
| Jänne, J; Kallio, A; Nikula, P | 1 |
| Eliassen, K; Osmundsen, H | 1 |
| Griffin, J; Kufe, D; Mitchell, T; Shafman, T; Sugiura, M | 1 |
| Gutterman, JU; Rosenblum, MG | 1 |
| Hagan, AC; Lachmann, PJ; Mayer, GD; Prakash, NJ; Rosenberger, AL; Sunkara, PS | 1 |
| Alhonen-Hongisto, L; Deen, DF; Marton, LJ; Oredsson, SM; Pegg, AE | 1 |
| Canellakis, ES; Flamigni, F; Kyriakidis, DA; Pawlak, JW | 1 |
| Herr, HW; Kleinert, EL | 1 |
| Haddox, MK; Johnson, LR; Seidel, ER | 1 |
| Jänne, J; Kallio, A; Käpyaho, K | 1 |
| Fleischmann, J; Heston, WD; Ratliff, TL; Tackett, RE | 1 |
| Bull, AW; Nigro, ND; Rozhin, J; Wilson, PS | 1 |
| Cavanaugh, PF; Pavelic, ZP; Porter, CW | 1 |
| Buckley, AR; Karrer, FM; Putnam, CW; Rhenman, B; Steinbronn, K; Warneke, JA | 1 |
| Alhonen-Hongisto, L; Elo, H; Fagerström, R; Jänne, J; Laine, R | 1 |
| Kamatani, N; Matsuta, K; Miyamoto, T; Morita, T; Morita, Y; Nishida, Y; Nishioka, K; Takeuchi, F | 1 |
| Griffin, J; Kufe, DW; Mitchell, T; Shafman, T | 1 |
| Burchenal, JH; Conti, PS; Herr, HW; Kleinert, EL; Whitmore, WF | 1 |
| Alhonen-Hongisto, L; Deen, DF; Hung, DT; Marton, LJ | 1 |
| Knuutila, S; Pohjanpelto, P | 1 |
| Chayen, A; Chayen, R; Mirelman, D | 1 |
| Mamont, PS; Pasquali, JL; Storck, D; Urlacher, A; Weryha, A | 1 |
| Heby, O; Kanje, M; Oredsson, SM | 1 |
| Alhonen-Hongisto, L; Elo, H; Fagerström, R; Jänne, J; Lumme, P; Seppänen, P | 1 |
| Katzenellenbogen, BS; Rorke, EA | 1 |
| Iwashima, A; Oku, T; Yamanishi, K | 1 |
| Bartolome, J; Persons, D; Slotkin, TA; Whitmore, WL | 1 |
| Marton, LJ; Oredsson, SM | 1 |
| Bartholeyns, J; Casara, P; Mamont, P | 1 |
| Black, O; Chang, BK; Gutman, R | 1 |
| Igarashi, K; Morris, DR | 1 |
| Borcich, JK; Byrd, D; Campbell, J; Davis, RL; Levin, VA | 1 |
| Cooper, E; Fucile, NW; Spaulding, SW | 1 |
| Andersson, LC; Karvonen, E; Pösö, H; Suomalainen, H | 1 |
| Altiere, RJ; Gillespie, MN; Hacker, AD; Olson, JW | 1 |
| Baylin, SB; Luk, GD; Yang, P | 1 |
| Gutin, PH; Wilson, CB | 1 |
| Fite, R; Herbst, EJ; Meeker, LD; Minocha, R; Ronan, AM; Thompson, HJ | 1 |
| Bergeron, RJ; Casero, RA; Porter, CW | 1 |
| Anehus, S; Heby, O; Oredsson, SM | 1 |
| Bacchi, CJ; Bienen, EJ; Clarkson, AB; Hutner, SH; McCann, PP; Nathan, HC; Sjoerdsma, A | 1 |
| Bey, P; McCann, PP; Pösö, H; Sjoerdsma, A; Tanskanen, R | 1 |
| Carstens, PH; de Gee, AL; Mansfield, JM; McCann, PP | 1 |
| Golden, JA; Santi, DV; Sjoerdsma, A | 1 |
| Anehus, S; Emanuelsson, H; Heby, O; Persson, L; Scheffler, IE; Sundler, F | 1 |
| Barlow, JL; Golden, JA; Santi, DV; Schechter, PJ; Sjoerdsma, A | 1 |
| Bartolome, J; Huguenard, J; Slotkin, TA | 1 |
| Bey, P; Danzin, C; Gerhart, F; Van Dorsselaer, V | 1 |
| Fozard, JR; Grove, J; Koch-Weser, J; Part, ML; Prakash, NJ; Schechter, PJ; Sjoerdsma, A | 1 |
| Chapman, SK | 1 |
| Anehus, S; Heby, O; Oredsson, S | 2 |
| Alhonen-Hongisto, L; Jänne, J | 1 |
| Fozard, JR; Grove, J; Part, ML; Prakash, NJ | 1 |
| Fowler, SK; Nishioka, K; Rao, PN; Sunkara, PS | 1 |
| Deen, DF; Marton, LJ; Seidenfeld, J | 1 |
| Baulieu, EE; Godeau, F; Mester, J; Younglai, EV | 1 |
| Gilad, GM; Gilad, VH | 2 |
| Chan, AW; Kellen, JA; Mirakian, A | 1 |
| Gray, JW; Marton, LJ; Seidenfeld, J | 1 |
| Alhonen-Hongisto, L | 1 |
| Fozard, JR; Grove, J; Prakash, NJ | 1 |
| Böhlen, P; Grosshans, E; Grove, J; Henry, M; Koch-Weser, J; Schechter, PJ; Tell, G | 1 |
| Deen, DF; Hung, DT; Marton, LJ; Seidenfeld, J | 1 |
| Alken, RG; Grove, J; Haegele, KD; Koch-Weser, J; Schechter, PJ | 1 |
| Fozard, JR; Grove, J; Mamont, PS | 1 |
| Knödgen, B; Richards, W; Seiler, N | 1 |
| Grosshans, E; Grove, J; Henry, M; Juillard, J; Koch-Weser, J; Schechter, PJ; Tell, G | 1 |
| Fowler, SK; Nishioka, K; Sunkara, PS | 1 |
| Choi, J; Scheffler, IE | 1 |
| Jefferson, LS; Pegg, AE; Pösö, H; Pritchard, ML; Seely, JE | 1 |
| Hölttä, E; Hovi, T; Korpela, H | 1 |
| Fair, WR; Heston, WD; Lazan, DW | 1 |
| Reddy, PR; Rukmini, V | 1 |
| Bethell, DR; Pegg, AE | 1 |
| Hervatin, SJ; Koch-Weser, J; Levin, VA; Marton, LJ; McCann, PP; Sjoerdsma, A | 1 |
| Bartholeyns, J; Koch-Weser, J | 1 |
| Alhonen-Hongisto, L; Jänne, J; Seppänen, P; Siimes, M | 2 |
| Persson, L | 1 |
| Grove, J; Joder-Ohlenbusch, AM; Mamont, PS; Nussli, M | 1 |
| Hölttä, E; Hovi, T; Jänne, J; Korpela, H | 1 |
| Bacchi, CJ; Hutner, SH; McCann, PP; Nathan, HC; Rescigno, D; Sjoerdsma, A | 1 |
| Hibasami, H; Pegg, AE; Shuttleworth, K | 1 |
| Kallio, A; McCann, PP | 1 |
| Korhonen, P; Pelkonen, O; Raunio, H; Skurnik, M | 1 |
| Danzin, C; Mamont, P; Wagner, J | 1 |
| Bethell, DR; Hibasami, H; Matsui, I; Pegg, AE | 1 |
| Erwin, BG; Florini, JR; Pegg, AE; Richman, RA; Stoscheck, CM | 1 |
| Jänne, J; Käpyaho, K; Linnamaa, K | 1 |
| Joder-Ohlenbusch, AM; Knödgen, B; Mamont, PS; Seiler, N; Siat, M | 1 |
| Elliot, QD; Herbst, EJ | 1 |
| Emanuelsson, H; Heby, O | 2 |
| Marton, LJ | 1 |
| Seppänen, P | 1 |
| Claverie, N; Danzin, C; Joder-Ohlenbusch, AM; Mamont, PS; Siat, M; Wagner, J | 1 |
| Alhonen-Hongisto, L; Ek-Kommonen, C; Jänne, J; Veijalainen, P | 1 |
| Pegg, AE; Seely, J; Zagon, IS | 1 |
| Bennett, RA; Pegg, AE; Pösö, H; Shuttleworth, K | 1 |
| Mitchell, GK; Mitchell, JL | 1 |
| Sunkara, PS; Verma, DS | 1 |
| Baylin, SB; Gazdar, AF; Goodwin, G; Luk, GD | 1 |
| Alhonen-Hongisto, L; Hölttä, E; Jänne, J; Seppänen, P | 1 |
| Agranoff, BW; Heacock, AM; Klinger, PD; Kohsaka, S; Porta, R | 1 |
| Carpenter, JR; Fozard, JR | 1 |
| Barnes, GA; Bartolome, J; Lerea, L; Seidler, FJ; Slotkin, TA; Trepanier, PA; Weigel, SJ; Whitmore, WL | 1 |
| Deen, DF; Marton, LJ; Oredsson, SM; Tofilon, PJ | 1 |
| Fozard, JR; Prakash, NJ | 1 |
| Fair, WR; Heston, WD; Kadmon, D; Lazan, DW | 2 |
| Hayashi, S; Kameji, T | 1 |
| YoungLai, EV | 1 |
| Pelkonen, O; Raunio, H | 1 |
| Bacchi, CJ; Garofalo, J; Hutner, SH; McLaughlin, SD; Mockenhaupt, D; Trueba, G | 1 |
| Böttger, M; Freitas, EK; Karbe, E; McCann, PP; Sjoerdsma, A | 1 |
| McCann, PP; Pegg, AE | 1 |
| Erwin, BG; Pegg, AE | 1 |
| Fuller, DJ; Gerner, EW | 2 |
| McCann, PP; Moon, HW; Runnels, PL; Schwartz, A; Welch, MJ | 1 |
| Bradford, MM; Chapman, WL; Hanson, WL; McCann, PP; Sjoerdsma, A; Waits, VB | 1 |
| Prakash, NJ; Rosenberger, AL; Sunkara, PS | 1 |
| Hougaard, DM; Larsson, LI | 1 |
| Boné, G; Gillet, JM; Herman, F | 1 |
| Fujimoto, S; Hirose, S; Igarashi, K; Okui, K; Shrestha, RD; Terao, K | 1 |
| Herrmann, AL; Nelson, FR; Slaga, TJ; Weeks, CE | 1 |
| Morgan, DM | 1 |
| Bacchi, CJ; Yarlett, N | 1 |
| Chmurzyńska, W; Grzelakowska-Sztabert, B; Manteuffel-Cymborowska, M; Peska, M | 2 |
| Bujidos, ML; Cubría, JC; Fouce, RB; Ordóñez, D; Reguera, RM | 1 |
| Byus, CV; Fukumoto, GH; Hawel, L; Tjandrawinata, RR | 1 |
| Byus, CV; Hawel, L; Tjandrawinata, RR | 1 |
| Bogle, RG; Mann, GE; Morgan, DM; Pearson, JD | 1 |
| Bacchi, CJ; Ciminelli, M; Garofalo, J; Goldberg, B; McCann, PP; Rattendi, D; Yarlett, N | 1 |
| Bedoya, AM; Hernandez, SM; Isola, EL; Lammel, EM; Schwarcz de Tarlovsky, MN | 1 |
| Hittelman, WN; Hong, WK; Lee, JJ; Lotan, R; Mitchell, MF; Nishioka, K; Tortolero-Luna, G; Wharton, JT | 1 |
| Grossie, VB; Nishioka, K | 1 |
| Durante, W; Liao, L; Peyton, KJ; Schafer, AI | 1 |
| Blachier, F; Mayeur, C; Robert, V; Selamnia, M | 1 |
| Hus-Citharel, A; Levillain, O | 1 |
| Kamio, Y; Muramoto, K; Onoda, M; Sugiyama, T; Takatsuka, Y; Tomita, T | 1 |
| Beliaeva, TN; Bulychev, AG; Leont'eva, EA; Mozhenok, TP | 1 |
| Galston, AW; Tiburcio, AF | 1 |
| Hawker, JR; Kelly, KA; Li, H; Meininger, CJ; Morris, SM; Wu, G | 1 |
| Caldefie, F; Chassagne, J; Cynober, L; Moinard, C; Tridon, A; Vasson, MP; Walrand, S | 1 |
| Diegelman, P; Kee, K; Kisiel, N; Kramer, DL; Merali, S; Porter, CW; Powell, CT; Vujcic, S | 1 |
| Akhtar, M; Blumberg, DR; Boucher, JL; Casero, RA; Chaturvedi, R; Cheng, Y; Cross, RK; Drachenberg, CB; Gobert, AP; Hacker, A; Mersey, BD; Wilson, KT | 1 |
| Allen, DA; Ashman, N; Harwood, SM; Kieswich, J; Mendes-Ribeiro, AC; Roberts, NB; Yaqoob, MM | 1 |
| Ando, A; Furuta, K; Igarashi, K; Ito, S; Kaneko, S; Maeda, M; Matsumura, M; Nishimura, K; Okuda-Ashitaka, E; Suzuki, M | 1 |
| Anamika, K; Bakre, AA; Bhattacharya, A; Bhattacharya, S; Jhingran, A; Madhubala, R; Padmanabhan, PK; Singh, S; Srinivasan, N | 1 |
| Gilbert, D; Gu, X; Higham, DJ; Reid, D | 1 |
| Gauvreau, GM; Grasemann, H; Inman, MD; Khanna, N; North, ML; Scott, JA | 1 |
| Minocha, SC; Sardesai, N; Shukle, RH; Subramanyam, S; Williams, CE; Zheng, C | 1 |
| Cordts, K; Gribbon, P; Hennig, A; Nau, WM; Nilam, M; Reinshagen, J; Schwedhelm, E | 1 |
| Alsford, S; Currier, RB; Horn, D; Macedo, JP; Rentsch, D; Wirdnam, C | 1 |
16 review(s) available for ornithine and eflornithine
| Article | Year |
|---|---|
Prevention of human cytomegalovirus infection.
Topics: Acyclovir; Adolescent; Child; Cytomegalovirus Infections; Eflornithine; Female; Humans; Infant, Newborn; Ornithine; Ornithine Decarboxylase Inhibitors | 1985 |
Chemotherapy of primary brain tumors.
Topics: Antineoplastic Combined Chemotherapy Protocols; Astrocytoma; Brain Neoplasms; Brain Stem; Child; Eflornithine; Ependymoma; Fluorouracil; Glioblastoma; Humans; Hydroxyurea; Lomustine; Medulloblastoma; Methotrexate; Mitoguazone; Mitolactol; Neoplasm Recurrence, Local; Ornithine; Prednisone; Risk; Thioguanine; Vincristine | 1985 |
The chemotherapeutic potential of polyamine antimetabolites.
Topics: Animals; Antimetabolites; Antineoplastic Agents; Body Weight; Cell Division; Cell Line; Child; Drug Interactions; Eflornithine; Female; Humans; Mice; Mitoguazone; Neoplasms; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats | 1986 |
Aspects of the biochemical pharmacology of methyl glyoxal bis(guanylhydrazone).
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Carnitine; Cell Division; DNA Replication; Eflornithine; Energy Metabolism; Humans; Kinetics; Leukemia; Male; Mitochondria; Mitoguazone; Nucleic Acids; Ornithine; Oxidation-Reduction; Palmitic Acid; Palmitic Acids; Polyamines; Protein Biosynthesis; Putrescine; Virus Replication | 1986 |
Recent advances in the biochemistry of polyamines in eukaryotes.
Topics: Acetylation; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Antiprotozoal Agents; Cells; Eflornithine; Enzyme Inhibitors; Eukaryotic Cells; Humans; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Proteins; Spermidine Synthase; Spermine Synthase | 1986 |
Chemoprevention of mammary carcinogenesis: a comparative review of the efficacy of a polyamine antimetabolite, retinoids, and selenium.
Topics: Animals; Eflornithine; Mammary Neoplasms, Experimental; Ornithine; Polyamines; Retinoids; Selenium | 1986 |
Polyamines in microorganisms.
Topics: Arginine; Aspergillus nidulans; Bacteria; Bacteriophages; Biodegradation, Environmental; Carboxy-Lyases; Eflornithine; Escherichia coli; Fungi; Guanine Nucleotides; Mutation; Neurospora crassa; Ornithine; Ornithine Decarboxylase; Physarum; Polyamines; Protein Biosynthesis; Saccharomyces cerevisiae; Spermine | 1985 |
[Current status of clinical results of new antitumor drugs].
Topics: Aminoacridines; Amsacrine; Anthracyclines; Anthraquinones; Antibiotics, Antineoplastic; Antineoplastic Agents; Aziridines; Benzoquinones; Carboplatin; Carubicin; Cisplatin; Daunorubicin; Doxorubicin; Eflornithine; Epirubicin; Humans; Idarubicin; Mitoxantrone; Naphthacenes; Neoplasms; Organoplatinum Compounds; Ornithine; Ribavirin | 1985 |
Ornithine decarboxylase as target of chemotherapy.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Cloning, Molecular; DNA; Drug Resistance; Eflornithine; Humans; Mice; Neoplasms; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; Subcellular Fractions | 1985 |
Chemoprevention and chemotherapy by inhibition of ornithine decarboxylase activity and polyamine synthesis: colonic, pancreatic, mammary, and renal carcinomas.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cell Division; Colonic Neoplasms; Eflornithine; Female; Humans; Kidney Neoplasms; Mammary Neoplasms, Experimental; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Pancreatic Neoplasms; Polyamines; Rats | 1985 |
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Eruptions; Drug Therapy, Combination; Eflornithine; Esophageal Neoplasms; Guanidines; Head and Neck Neoplasms; Humans; Kidney Neoplasms; Leukemia; Leukemia L1210; Lung Neoplasms; Mice; Mitoguazone; Muscular Diseases; Nausea; Neoplasms; Ornithine; Polyamines; Stilbamidines; Structure-Activity Relationship | 1983 |
Observations on the mechanism of skin tumor promotion by phorbol esters.
Topics: Adenosylmethionine Decarboxylase; Animals; Caenorhabditis elegans Proteins; Carrier Proteins; Cell Division; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Protein Kinase C; Protein Kinases; Receptors, Drug; Receptors, Immunologic; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Chemotherapeutic implications of polyamine biosynthesis inhibition.
Topics: Animals; Drug Evaluation; Eflornithine; Female; Humans; Male; Melanoma; Mice; Middle Aged; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protozoan Infections; Trypanosomiasis, African | 1984 |
Use of polyamine antimetabolites in experimental tumours and in human leukemia.
Topics: Animals; Antimetabolites, Antineoplastic; Drug Administration Schedule; Drug Therapy, Combination; Eflornithine; Humans; Leukemia; Mitoguazone; Neoplasms, Experimental; Ornithine; Polyamines | 1981 |
Polyamine metabolism and function.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Division; Eflornithine; Humans; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; S-Adenosylmethionine; Spermidine | 1982 |
Parasite polyamine metabolism: targets for chemotherapy.
Topics: Animals; Antiporters; Bacterial Proteins; Biological Transport; Eflornithine; Escherichia coli Proteins; Female; Humans; Ornithine; Polyamines; Putrescine; Trichomonas vaginalis; Trichomonas Vaginitis | 1994 |
4 trial(s) available for ornithine and eflornithine
| Article | Year |
|---|---|
Pneumocystis carinii pneumonia in the patient with AIDS.
Topics: Acquired Immunodeficiency Syndrome; Animals; Bronchoscopy; Clinical Trials as Topic; Dapsone; Drug Combinations; Drug Therapy, Combination; Eflornithine; Humans; Male; Ornithine; Pentamidine; Pneumocystis; Pneumonia, Pneumocystis; Pyrimethamine; Sulfadiazine; Sulfamethoxazole; Therapeutic Irrigation; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
Treatment of gambiense sleeping sickness in the Sudan with oral DFMO (DL-alpha-difluoromethylornithine), an inhibitor of ornithine decarboxylase; first field trial.
Topics: Adolescent; Adult; Cerebrospinal Fluid Proteins; Child; Clinical Trials as Topic; Eflornithine; Female; Humans; Leukocyte Count; Male; Middle Aged; Ornithine; Ornithine Decarboxylase Inhibitors; Sudan; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1985 |
Methylglyoxal-bis(guanylhydrazone) (Methyl-GAG): current status and future prospects.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Chemical Phenomena; Chemistry; Clinical Trials as Topic; Colonic Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Eruptions; Drug Therapy, Combination; Eflornithine; Esophageal Neoplasms; Guanidines; Head and Neck Neoplasms; Humans; Kidney Neoplasms; Leukemia; Leukemia L1210; Lung Neoplasms; Mice; Mitoguazone; Muscular Diseases; Nausea; Neoplasms; Ornithine; Polyamines; Stilbamidines; Structure-Activity Relationship | 1983 |
Phase I dose de-escalation trial of alpha-difluoromethylornithine in patients with grade 3 cervical intraepithelial neoplasia.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Arginine; Biogenic Polyamines; Dose-Response Relationship, Drug; Drug Administration Schedule; Eflornithine; Enzyme Inhibitors; Female; Humans; Ornithine; Ornithine Decarboxylase; Uterine Cervical Dysplasia; Uterine Cervical Neoplasms | 1998 |
466 other study(ies) available for ornithine and eflornithine
| Article | Year |
|---|---|
Inhibition of deoxyribonucleic acid synthesis by difluoromethylornithine. Role of polyamine metabolism in monocrotaline-induced pulmonary hypertension.
Topics: Animals; Biogenic Polyamines; Blood Pressure; DNA; DNA Replication; Eflornithine; Hypertension, Pulmonary; Lung; Male; Monocrotaline; Ornithine; Rats; Rats, Inbred Strains; Thymidine | 1992 |
Leishmania infantum: polyamine biosynthesis and levels during the growth of promastigotes.
Topics: Animals; Decarboxylation; Diminazene; Dogs; Eflornithine; Leishmania donovani; Methionine; Ornithine; Polyamines; Putrescine; Spermidine; Spermine; Trypanocidal Agents | 1991 |
Amelioration of thrombocytopenia with concomitant ornithine in sarcoma-bearing rats receiving high dose difluoromethylornithine.
Topics: Animals; Biogenic Polyamines; Drug Therapy, Combination; Eflornithine; Kidney; Liver; Male; Ornithine; Rats; Rats, Inbred F344; Sarcoma, Experimental; Spleen; Thrombocytopenia | 1991 |
The level of substrate ornithine can alter polyamine-dependent DNA synthesis following phorbolester stimulation of cultured hepatoma cells.
Topics: Animals; Arginine; Blood; Clone Cells; Culture Media; DNA; Eflornithine; Insulin; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Rats; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1991 |
Alpha-difluoromethylornithine inhibits bone resorption in vitro without decreasing beta-glucuronidase release.
Topics: Animals; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Cells, Cultured; Eflornithine; Female; Glucuronidase; Male; Mice; Mice, Inbred Strains; Ornithine; Phosphates; Polyamines; Sodium Fluoride | 1991 |
Polyamine metabolism in Pneumocystis carinii.
Topics: Animals; Arginine; Eflornithine; Lung; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pentamidine; Pneumocystis; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1991 |
Attenuation of trophic response to gastrin after inhibition of ornithine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Colon; Digestive System; DNA; Duodenum; Eflornithine; Gastric Mucosa; Gastrins; Intestinal Mucosa; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pentagastrin; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA | 1985 |
Effects of the irreversible ornithine decarboxylase inhibitor, alpha-difluoromethylornithine, aflatoxin B1, and choline deficiency on hepatocarcinogenesis.
Topics: Aflatoxin B1; Aflatoxins; alpha-Fetoproteins; Animals; Choline Deficiency; DNA; Eflornithine; gamma-Glutamyltransferase; Liver; Liver Neoplasms, Experimental; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred F344; Thymidine | 1985 |
Effects of alpha-difluoromethyl ornithine on alpha-fetoprotein and albumin secretion in human hepatoma cell line, PLC/PRF/5.
Topics: Albumins; alpha-Fetoproteins; Carcinoma, Hepatocellular; Cell Line; Cycloheximide; Dose-Response Relationship, Drug; Eflornithine; Humans; Liver Neoplasms; Ornithine | 1985 |
[Therapy with inhibitors of polyamine biosynthesis in refractory prostatic carcinoma. An experimental and clinical study].
Topics: Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carboxy-Lyases; Carcinoma; Eflornithine; Estrogens; Humans; Male; Mitoguazone; Neoplasm Metastasis; Ornithine; Ornithine Decarboxylase Inhibitors; Prostatic Hyperplasia; Prostatic Neoplasms; Prostatitis; Putrescine; Rats; Spermidine; Spermine | 1985 |
Effects of alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase, on nucleic acids and proteins in developing rat brain: critical perinatal periods for regional selectivity.
Topics: Aging; Animals; Body Weight; Brain; DNA; Eflornithine; Female; Injections, Subcutaneous; Nerve Tissue Proteins; Organ Size; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pregnancy; Prenatal Exposure Delayed Effects; Rats; RNA | 1986 |
Inhibition of ileal and colonic ornithine decarboxylase activity by alpha-difluoromethylornithine in rats: transient atrophic changes and loss of postresectional adaptive growth.
Topics: Adaptation, Physiological; Animals; Colon; DNA; Eflornithine; Hyperplasia; Ileum; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Postoperative Period; Rats; Rats, Inbred Strains; RNA | 1986 |
Transcriptional inhibition in early chick embryos as a result of polyamine depletion.
Topics: Amanitins; Animals; Autoradiography; Cell Cycle; Chick Embryo; Dactinomycin; Dichlororibofuranosylbenzimidazole; DNA; Eflornithine; Electrophoresis, Agar Gel; Gene Expression Regulation; Ornithine; Polyamines; Protein Biosynthesis; Ribonucleotides; RNA; Transcription, Genetic | 1986 |
Inhibition of ornithine decarboxylase alters neurological responsiveness to a tremorigen.
Topics: Animals; Behavior, Animal; Chlordecone; Eflornithine; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Inbred F344; Tremor | 1986 |
Characterization of difluoromethylornithine-resistant mouse and human tumour cell lines.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Arginase; Cell Line; Drug Resistance; Eflornithine; Humans; Mice; Ornithine; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Spermidine; Tumor Cells, Cultured | 1989 |
Reduction of difluoromethylornithine-induced thrombocytopenia in rats with ornithine while maintaining antitumor activity.
Topics: Animals; Biogenic Polyamines; Eflornithine; Male; Ornithine; Rats; Rats, Inbred F344; Sarcoma, Experimental; Thrombocytopenia | 1989 |
Ornithine aminotransferase activity, tissue ornithine concentrations and polyamine metabolism.
Topics: Animals; Brain; Eflornithine; Female; Male; Mice; Mice, Hairless; Ornithine; Ornithine Decarboxylase Inhibitors; Ornithine-Oxo-Acid Transaminase; Polyamines; Rats; Rats, Inbred Strains; Transaminases | 1989 |
Stimulus-secretion coupling of arginine-induced insulin release. Functional response of islets to L-arginine and L-ornithine.
Topics: Animals; Arginine; Calcium; Dose-Response Relationship, Drug; Eflornithine; Glucose; Inositol; Insulin; Insulin Secretion; Islets of Langerhans; Lysine; Ornithine; Oxidation-Reduction; Polyamines; Rats | 1989 |
Ornithine aminotransferase activity, liver ornithine concentration and acute ammonia intoxication.
Topics: Acetates; Administration, Oral; Ammonia; Animals; Arginine; Creatinine; Eflornithine; Female; Injections, Intraperitoneal; Liver; Mice; Ornithine; Ornithine-Oxo-Acid Transaminase; Orotic Acid; Transaminases; Urea | 1989 |
Behavioural and electrocortical effects after injection of two ornithine decarboxylase inhibitors into several areas of the brain in the rat.
Topics: Amygdala; Animals; Basal Ganglia; Behavior, Animal; Cerebral Cortex; Eflornithine; Electroencephalography; Hippocampus; Injections; Injections, Intraventricular; Male; Muscimol; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Stereotyped Behavior; Thalamus | 1989 |
Inhibition of bone resorption by alpha-difluoromethylornithine may not be mediated by polyamine depletion.
Topics: Animals; Biogenic Polyamines; Bone Resorption; Calcitriol; Calcium; Calcium Radioisotopes; Culture Techniques; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Parathyroid Hormone | 1989 |
Temporal profiles of proteins responsive to transient ischemia.
Topics: Adenosylmethionine Decarboxylase; Animals; Brain; Cerebral Cortex; Eflornithine; Ischemic Attack, Transient; Kinetics; Male; Nerve Tissue Proteins; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred Strains; RNA Polymerase I; RNA Polymerase II; Substance P | 1985 |
Ornithine decarboxylase inhibition and the malaria-infected red cell: a model for polyamine metabolism and growth.
Topics: Cells, Cultured; DNA; Eflornithine; Erythrocytes; Humans; Malaria; Ornithine; Ornithine Decarboxylase Inhibitors; Plasmodium falciparum; Polyamines; Protein Biosynthesis; RNA | 1985 |
Difluoromethylornithine for Pneumocystis carinii?
Topics: Eflornithine; Humans; Ornithine; Pneumonia, Pneumocystis | 1985 |
Effects of alpha-difluoromethylornithine on polyamine biosynthesis and tyrosine hydroxylase induction in the adrenal gland of the rat subjected to stress or apomorphine.
Topics: Adrenal Glands; Animals; Apomorphine; Cold Temperature; Eflornithine; Enzyme Induction; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Restraint, Physical; Spermidine; Spermine; Stress, Physiological; Tyrosine 3-Monooxygenase | 1985 |
Evidence against putrescine and polyamines as endogenous mediators of fever.
Topics: Animals; Eflornithine; Endotoxins; Fever; Ornithine; Polyamines; Putrescine; Rabbits; Shigella dysenteriae; Spermidine; Spermine | 1985 |
Postnatal development of brain alpha 1-adrenergic receptors: in vitro autoradiography with [125I]HEAT in normal rats and rats treated with alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
Topics: Adrenergic alpha-Antagonists; Age Factors; Animals; Animals, Newborn; Autoradiography; Brain; Eflornithine; Female; Male; Ornithine; Ornithine Decarboxylase; Phenethylamines; Rats; Rats, Inbred Strains; Tetralones; Time Factors | 1985 |
Effects of lesions and ganglioside GM1 treatment on striatal polyamine levels and nigral DA neurons. A role of putrescine in the neurotropic activity of gangliosides.
Topics: Animals; Corpus Striatum; Dopamine; Eflornithine; G(M1) Ganglioside; Male; Neurons; Ornithine; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Substantia Nigra; Tyrosine 3-Monooxygenase | 1985 |
A role for transglutaminase in neurotransmitter release by rat brain synaptosomes.
Topics: Animals; Brain; Cadaverine; Catecholamines; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Eflornithine; gamma-Aminobutyric Acid; Male; Methylamines; Neurotransmitter Agents; Ornithine; Putrescine; Rats; Rats, Inbred Strains; Synaptosomes; Transglutaminases | 1986 |
Polyamines contribute to calcium-stimulated release of aspartate from brain particulate fractions.
Topics: Animals; Aspartic Acid; Calcium; Dopamine; Eflornithine; Frontal Lobe; gamma-Aminobutyric Acid; Male; Neurotransmitter Agents; Ornithine; Ornithine Decarboxylase; Polyamines; Potassium; Putrescine; Rats; Synaptosomes | 1986 |
Effect of prenatal imipramine exposure on development of the postnatal rat heart and brain.
Topics: Aging; Animals; Body Weight; Brain; Dihydroalprenolol; Eflornithine; Female; Heart; Imipramine; Litter Size; Maternal-Fetal Exchange; Myocardium; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta | 1986 |
[Anticancer treatment with a combination of antimetabolites of polyamine and pyrimidine].
Topics: Animals; DNA Replication; Drug Therapy, Combination; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Nude; Mitoguazone; Ornithine; Polyamines; Spermine; Stomach Neoplasms | 1985 |
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoma; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Ornithine; Stomach Neoplasms | 1986 |
Effect of difluoromethylornithine, an inhibitor of polyamine biosynthesis, on the topoisomerase II-mediated DNA scission produced by 4'-(9-acridinylamino)methanesulfon-m-anisidide in L1210 murine leukemia cells.
Topics: Aminoacridines; Amsacrine; Animals; Antineoplastic Agents; DNA Topoisomerases, Type I; DNA, Neoplasm; Eflornithine; Intercalating Agents; Leukemia L1210; Mice; Nucleic Acid Conformation; Ornithine; Polyamines | 1985 |
Difluoromethylornithine-induced amplification of ornithine decarboxylase genes in Ehrlich ascites carcinoma cells.
Topics: Animals; Base Sequence; Carcinoma, Ehrlich Tumor; Cells, Cultured; Deoxyribonuclease EcoRI; DNA; DNA Restriction Enzymes; Drug Resistance; Eflornithine; Gene Amplification; Mice; Nucleic Acid Hybridization; Ornithine; Ornithine Decarboxylase | 1985 |
Formation of cadaverine as an effect of alpha-difluoromethylornithine on chick embryo fibroblasts transformed by rous sarcoma virus.
Topics: Animals; Avian Sarcoma Viruses; Cadaverine; Cell Transformation, Neoplastic; Cell Transformation, Viral; Chick Embryo; Diamines; Eflornithine; Fibroblasts; Ornithine; Polyamines; Proteins; Thymidine | 1985 |
Plasmodium berghei: inhibitors of ornithine decarboxylase block exoerythrocytic schizogony.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Eflornithine; Erythrocytes; Humans; Liver Neoplasms; Malaria; Mice; Mice, Inbred A; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase Inhibitors; Plasmodium berghei; Primaquine; Spermidine | 1985 |
Relationship of ornithine decarboxylase activity and cAMP metabolism to proliferation of normal human bronchial epithelial cells.
Topics: Bronchi; Cell Division; Cholera Toxin; Clone Cells; Culture Media; Cyclic AMP; Eflornithine; Epidermal Growth Factor; Epinephrine; Epithelial Cells; Epithelium; Humans; Isoproterenol; Ornithine; Ornithine Decarboxylase; Pituitary Gland; Propranolol; Tissue Extracts | 1985 |
Tumourigenicity, cell-surface glycoprotein changes and ornithine decarboxylase gene pattern in Ehrlich ascites-carcinoma cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Deoxyribonuclease EcoRI; DNA Restriction Enzymes; DNA, Neoplasm; Eflornithine; Electrophoresis, Polyacrylamide Gel; Gene Amplification; Glycoproteins; Membrane Proteins; Mice; Ornithine; Ornithine Decarboxylase; Phenotype; Putrescine | 1985 |
Association of increased polyamine levels with isoproterenol-stimulated mucin secretion in the rat submandibular gland.
Topics: Animals; Eflornithine; Glucosamine; Isoproterenol; L-Lactate Dehydrogenase; Male; Mucins; Ornithine; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Receptors, Adrenergic, beta; Submandibular Gland; Time Factors | 1985 |
Human lung tumor sensitivity to difluoromethylornithine as related to ornithine decarboxylase messenger RNA levels.
Topics: Carcinoma; Carcinoma, Small Cell; Cell Cycle; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; RNA, Messenger | 1986 |
Anchorage dependency effects on difluoromethylornithine cytotoxicity in human lung carcinoma cells.
Topics: Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Aggregation; Cell Communication; Cell Survival; Cells, Cultured; Cytoskeleton; Eflornithine; Humans; Lung Neoplasms; Ornithine; Polyamines | 1986 |
Long-term maintenance therapy of established human small cell variant lung carcinoma implants in athymic mice with a cyclic regimen of difluoromethylornithine.
Topics: Animals; Body Weight; Carcinoma, Small Cell; Cell Aggregation; Eflornithine; Female; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Ornithine; Transplantation, Heterologous | 1986 |
The in vivo inhibition of mouse brain protein kinase-C by retinoic acid.
Topics: Animals; Brain; Carrier Proteins; Dose-Response Relationship, Drug; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Kinase C; Receptors, Retinoic Acid; Retinol-Binding Proteins; Retinol-Binding Proteins, Plasma; Tretinoin | 1986 |
Effect of 1,3,6-triaminohexane and 1,4,7-triaminoheptane on growth and polyamine metabolism in SV-3T3 cells treated with 2-difluoromethylornithine.
Topics: Animals; Cell Division; Cell Line; Cell Transformation, Viral; Eflornithine; Fibroblasts; Heptanes; Hexanes; Ornithine; Polyamines; Putrescine; S-Adenosylmethionine; Simian virus 40; Spermidine | 1986 |
Phase II trials of alpha-difluoromethylornithine, an inhibitor of polyamine synthesis, in advanced small cell lung cancer and colon cancer.
Topics: Aged; Antineoplastic Agents; Carcinoma, Small Cell; Colonic Neoplasms; Drug Evaluation; Eflornithine; Female; Gastrointestinal Diseases; Hearing Loss, High-Frequency; Hematologic Diseases; Humans; Lung Neoplasms; Male; Middle Aged; Ornithine; Polyamines | 1986 |
Modulation of etoposide cytotoxicity and DNA strand scission in L1210 and 8226 cells by polyamines.
Topics: Animals; Cell Survival; DNA Topoisomerases, Type II; DNA, Neoplasm; DNA, Single-Stranded; Eflornithine; Etoposide; Humans; Leukemia L1210; Mice; Multiple Myeloma; Nucleic Acid Conformation; Ornithine; Podophyllotoxin; Polyamines; Putrescine | 1986 |
Altered cell cycle phase distributions in cultured human carcinoma cells partially depleted of polyamines by treatment with difluoromethylornithine.
Topics: Cell Cycle; Cell Line; DNA; Dose-Response Relationship, Drug; Eflornithine; Flow Cytometry; Humans; Ornithine; Polyamines; Putrescine | 1986 |
Relationship between ornithine decarboxylase activity and hexamethylene bisacetamide-induced differentiation of murine erythroleukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Cell Line; Clone Cells; Dexamethasone; Eflornithine; Erythrocytes; Interphase; Kinetics; Leukemia, Erythroblastic, Acute; Mice; Ornithine; Ornithine Decarboxylase; Putrescine; Spermidine; Spermine | 1986 |
Difluoromethylornithine enhances inhibition of melanoma cell growth in soft agar by dexamethasone, clone A interferon and retinoic acid.
Topics: Cell Line; Cell Survival; Dexamethasone; Drug Combinations; Drug Synergism; Eflornithine; Humans; Interferon Type I; Melanoma; Ornithine; Putrescine; Tretinoin | 1986 |
[Studies on hyperthermia by the use of a thermosensitizing drug].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; DNA Replication; Eflornithine; Humans; Hyperthermia, Induced; Mice; Mice, Inbred BALB C; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Ornithine; Stomach Neoplasms | 1986 |
Marked and prolonged inhibition of mammalian ornithine decarboxylase in vivo by esters of (E)-2-(fluoromethyl)dehydroornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cells, Cultured; Dose-Response Relationship, Drug; Eflornithine; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prostate; Rats; Testis; Thymus Gland | 1986 |
Necessity of antibody response in the treatment of African trypanosomiasis with alpha-difluoromethylornithine.
Topics: Animals; Antibody Formation; Antigens, Protozoan; Dexamethasone; Eflornithine; Immunity; Immunosuppression Therapy; Male; Organ Size; Ornithine; Rats; Spleen; Thymus Gland; Trypanosomiasis, African | 1986 |
Uptake of alpha-difluoromethylornithine by Trypanosoma brucei brucei.
Topics: Animals; Arginine; Biological Transport; Diffusion; Eflornithine; Lysine; Ornithine; Temperature; Trypanosoma brucei brucei | 1986 |
Effect of alpha-difluoromethylornithine on L-phenylalanine mustard-induced cytotoxicity and DNA interstrand cross-linking in a human cell line in vitro.
Topics: Cell Cycle; Cell Line; Cell Survival; Cross-Linking Reagents; DNA; Drug Synergism; Eflornithine; Humans; Melphalan; Ornithine | 1986 |
Comparison of the biological effects of four irreversible inhibitors of ornithine decarboxylase in two murine lymphocytic leukemia cell lines.
Topics: Alkynes; Animals; Biological Transport; Cell Cycle; Cell Survival; Diamines; Eflornithine; Leukemia L1210; Leukemia L5178; Leukemia, Lymphoid; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Purine-Nucleoside Phosphorylase; S-Adenosylmethionine | 1986 |
Reduced cytocidal efficacy for adriamycin in cultured human carcinoma cells depleted of polyamines by difluoromethylornithine treatment.
Topics: Adenocarcinoma; Cell Line; Cell Survival; Doxorubicin; Eflornithine; Humans; Ornithine; Polyamines | 1986 |
Regulation of polyamine biosynthesis in tobacco. Effects of inhibitors and exogenous polyamines on arginine decarboxylase, ornithine decarboxylase, and S-adenosylmethionine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Arginine; Carboxy-Lyases; Cell Survival; Cells, Cultured; Eflornithine; Half-Life; Molecular Weight; Nicotiana; Ornithine; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Polyamines | 1986 |
Effect of polyamine limitation on DNA synthesis and development of mouse preimplantation embryos in vitro.
Topics: Animals; Blastocyst; Culture Media; DNA; Eflornithine; Embryonic Development; Female; In Vitro Techniques; Mice; Mitoguazone; Ornithine; Polyamines; Pregnancy; Spermine | 1986 |
Autocrine stimulation by estradiol-regulated growth factors of rat hormone-responsive mammary cancer: interaction with the polyamine pathway.
Topics: Animals; Cells, Cultured; Culture Media; Eflornithine; Estradiol; Female; Growth Substances; Mammary Neoplasms, Experimental; Methylnitrosourea; Molecular Weight; Ornithine; Polyamines; Rats; Rats, Inbred Strains | 1986 |
Heart ornithine decarboxylase from control and isoproterenol-treated rats: kinetic properties, multiple forms and subcellular distribution.
Topics: Animals; Dithiothreitol; Eflornithine; Female; Isoenzymes; Isoproterenol; Kinetics; Myocardium; Ornithine; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Subcellular Fractions | 1986 |
Synergistic antileukemic effect of two polyamine synthesis inhibitors. Host survival and cell-cycle kinetic analysis.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Cycle; Drug Synergism; Eflornithine; Leukemia L1210; Male; Mice; Mice, Inbred Strains; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1986 |
Posttranscriptional regulation of ornithine decarboxylase activity.
Topics: Animals; Cell Cycle; Cell Line; Cricetinae; Cricetulus; Eflornithine; Emetine; Female; Half-Life; Ornithine; Ornithine Decarboxylase; Ovary; Protein Processing, Post-Translational; Putrescine; RNA, Messenger | 1986 |
Restoration of the polyamine contents in rat hepatoma tissue-culture cells after inhibition of polyamine biosynthesis. Relationship with cell proliferation.
Topics: Alkynes; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1986 |
Phase I study of alpha-difluoromethylornithine and methyl-GAG.
Topics: Adolescent; Adult; Aged; Anemia, Hemolytic; Antineoplastic Combined Chemotherapy Protocols; Deafness; Drug Evaluation; Eflornithine; Humans; Leukopenia; Middle Aged; Mitoguazone; Neoplasms; Ornithine; Thrombocytopenia | 1986 |
Autoradiographic measurement of relative changes in ornithine decarboxylase in axotomized superior cervical ganglion neurons.
Topics: Animals; Axons; Eflornithine; Ganglia, Sympathetic; Ornithine; Ornithine Decarboxylase; Sympathectomy, Chemical; Tritium | 1986 |
Plasmodium falciparum: synchronization of cultures with DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis.
Topics: Animals; Eflornithine; Flow Cytometry; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Plasmodium falciparum; Polyamines | 1986 |
In vivo effects of DL-alpha-difluoromethylornithine on the polyamine and nucleotide phosphate metabolism in P388/S leukemia cells.
Topics: Animals; Cell Line; Eflornithine; Leukemia P388; Leukemia, Experimental; Male; Mice; Mice, Inbred Strains; Nucleotides; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Time Factors | 1986 |
Essential role of polyamine metabolism in hepatic regeneration. Inhibition of deoxyribonucleic acid and protein synthesis and tissue regeneration by difluoromethylornithine in the rat.
Topics: Animals; Depression, Chemical; DNA; Eflornithine; Hepatectomy; Liver; Liver Regeneration; Male; Organ Size; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Proteins; Rats; Rats, Inbred Lew; Rats, Inbred Strains; Time Factors | 1986 |
Autoradiographic localization of ornithine decarboxylase in cerebellar cortex of the developing rat with [3H]alpha-difluoromethylornithine.
Topics: Animals; Autoradiography; Cerebellar Cortex; Eflornithine; Isoproterenol; Ornithine; Ornithine Decarboxylase; Rats; Rats, Inbred Strains | 1986 |
Urea concentration and ornithine decarboxylase in liver of female rats.
Topics: Animals; Carbamoyl-Phosphate Synthase (Ammonia); Eflornithine; Female; Glutamates; Kinetics; Liver; Ornithine; Ornithine Decarboxylase; Pregnancy; Rats; Rats, Inbred Strains; Thioacetamide; Urea | 1986 |
Identification of polyamines in the cochlea of the rat and their potential role in hearing.
Topics: Animals; Auditory Threshold; Cochlea; Eflornithine; Hearing; Hearing Disorders; Male; Ornithine; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred Strains | 1986 |
Selective modulation by alpha-difluoromethylornithine of T-lymphocyte and antibody-mediated cytotoxic responses to mouse tumor allografts.
Topics: Animals; Antibody Formation; Cell Cycle; Cytotoxicity, Immunologic; Eflornithine; Female; Immunization; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Ornithine; Spermidine; Spleen; T-Lymphocytes, Cytotoxic; Time Factors; Transplantation, Homologous | 1986 |
Effects of DFMO-induced polyamine depletion on human tumor cell sensitivity to antineoplastic DNA-crosslinking drugs.
Topics: Adenocarcinoma; Alkylating Agents; Antineoplastic Agents; Cell Line; Cell Survival; Chlorambucil; DNA, Neoplasm; Eflornithine; Humans; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Thiotepa | 1986 |
Effect of tamoxifen and D,L-2-difluoromethylornithine on the growth, ornithine decarboxylase activity and polyamine content of mammary carcinomas induced by 1-methyl-1-nitrosourea.
Topics: Animals; Eflornithine; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Ornithine; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred Strains; Tamoxifen | 1986 |
Polyamines in 1 alpha, 25-dihydroxycholecalciferol-induced differentiation of human promyelocytic leukemia cells, HL-60.
Topics: Acetyltransferases; Calcitriol; Cell Differentiation; Cell Division; Cell Line; Eflornithine; Humans; Leukemia, Myeloid; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1986 |
Polyamine inhibitors.
Topics: Acquired Immunodeficiency Syndrome; Animals; Eflornithine; Humans; Ornithine; Pneumonia, Pneumocystis; Polyamines | 1986 |
Ornithine decarboxylase inhibition and the uterotrophic response to oestrogen in rats.
Topics: Animals; Body Water; Contraceptives, Postcoital, Synthetic; Eflornithine; Estradiol; Female; Organ Size; Ornithine; Ornithine Decarboxylase Inhibitors; Ovariectomy; Polyamines; Rats; Regional Blood Flow; Uterus | 1986 |
Intrinsic and extrinsic factors in estrogen action in human breast cancer: role of polyamines and pituitary factors.
Topics: Animals; Breast Neoplasms; Cell Line; Drug Synergism; Eflornithine; Estrogens; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Ornithine; Ornithine Decarboxylase; Pituitary Gland; Pituitary Neoplasms; Polyamines; Transplantation, Heterologous | 1986 |
Additive and differential biological activity of alpha-interferon A, difluoromethylornithine, and their combination on established human lung cancer cell lines.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Line; Dopa Decarboxylase; Dose-Response Relationship, Drug; Eflornithine; Gene Expression Regulation; Humans; Interferon Type I; Lung Neoplasms; Ornithine; Proto-Oncogenes; Recombinant Proteins | 1986 |
Effect of alpha-difluoromethylornithine alone and in combination with doxorubicin hydrochloride, cis-diamminedichloroplatinum (II), and vinblastine sulfate on the growth of P3J cells in vitro.
Topics: Antineoplastic Combined Chemotherapy Protocols; Burkitt Lymphoma; Cell Cycle; Cell Line; Cell Survival; Cisplatin; Dose-Response Relationship, Drug; Doxorubicin; Drug Synergism; Eflornithine; Humans; Ornithine; Polyamines; Vinblastine | 1986 |
Modulation of mouse skin tumor promotion by dietary 13-cis-retinoic acid and alpha-difluoromethylornithine.
Topics: Animals; Diet; Eflornithine; Female; Isotretinoin; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Papilloma; Skin; Skin Neoplasms; Tetradecanoylphorbol Acetate; Tretinoin | 1986 |
Polyamines and growth regulation of cultured human breast cancer cells by 17 beta-oestradiol.
Topics: Breast Neoplasms; Cell Division; Cell Line; Eflornithine; Estradiol; Humans; Insulin; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine; Tamoxifen | 1986 |
The effect of alpha-difluoromethylornithine on natural killer cell and tumoricidal macrophage induction by interferon in vivo.
Topics: Animals; Cytotoxicity, Immunologic; Eflornithine; Interferon Type I; Killer Cells, Natural; Macrophages; Male; Melanoma; Mice; Mice, Inbred C57BL; Ornithine; Polyamines | 1986 |
Polyamine depletion increases cellular ribonucleotide levels.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Line; Chromatography, High Pressure Liquid; Eflornithine; Mice; Ornithine; Putrescine; Rats; S-Adenosylmethionine; Spermine | 1986 |
Alpha-difluoromethylornithine infusion and cardiac arrest.
Topics: Acquired Immunodeficiency Syndrome; Adult; Antiprotozoal Agents; Eflornithine; Female; Heart Arrest; Humans; Ornithine; Pneumonia, Pneumocystis | 1986 |
Induction of mouse epidermal ornithine decarboxylase by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate: dependence on calcium availability.
Topics: Animals; Autoradiography; Calcimycin; Calcium; Chemical Precipitation; Densitometry; Eflornithine; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Induction; Female; Mice; Nucleic Acid Hybridization; Ornithine; Ornithine Decarboxylase; Phorbols; Protein Binding; RNA, Messenger; Skin; Tetradecanoylphorbol Acetate | 1986 |
Role of ornithine decarboxylase in proliferation of prolactin-dependent lymphoma cells.
Topics: Animals; Cell Division; Cell Line; Eflornithine; Growth Hormone; Humans; Kinetics; Lymphoma; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Prolactin | 1986 |
[Antiproliferative activity of difluoromethylornithine and the factors decreasing its effectiveness in malignant growth].
Topics: Animals; Antineoplastic Agents; Bacillus megaterium; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eflornithine; Escherichia coli; Liver Regeneration; Melanoma; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Ornithine; Ornithine Decarboxylase Inhibitors; Plasmacytoma; Rats | 1986 |
Radiosensitization of human tumor cells by alpha-difluoromethylornithine.
Topics: Breast Neoplasms; Cell Division; Cell Line; Cell Survival; DNA Repair; DNA, Neoplasm; Eflornithine; Humans; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Radiation-Sensitizing Agents | 1986 |
Age dependency of the metabolic conversion of polyamines into amino acids in IMR-90 human embryonic lung diploid fibroblasts.
Topics: Amino Acids; Cell Line; Cell Survival; Diploidy; Eflornithine; Enzyme Induction; Fibroblasts; Humans; Lysine; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Processing, Post-Translational; Putrescine | 1986 |
alpha-Difluoromethylornithine does not bind to ornithine decarboxylase-antizyme complex.
Topics: Animals; Eflornithine; Macromolecular Substances; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Proteins; Rats | 1986 |
Red blood cell polyamine levels and host toxicity during continuous alpha-difluoromethylornithine infusion.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Dose-Response Relationship, Drug; Eflornithine; Erythrocytes; Intestinal Mucosa; Male; Mitoguazone; Neoplasms, Experimental; Ornithine; Platelet Count; Polyamines; Rats; Rats, Inbred F344 | 1986 |
Polyamine depletion following exposure to DL-alpha-difluoromethylornithine both in vivo and in vitro initiates morphological alterations and mitochondrial activation in a monomorphic strain of Trypanosoma brucei brucei.
Topics: Animals; Dihydrolipoamide Dehydrogenase; Eflornithine; Male; Mitochondria; Ornithine; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Trypanosoma brucei brucei | 1986 |
Polyamine biosynthesis in trichomonads.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Culture Media; Eflornithine; Eukaryota; Ornithine; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine; Trichomonas vaginalis; Tritrichomonas | 1986 |
Ornithine decarboxylase and mucosal growth in response to feeding.
Topics: Animals; Eflornithine; Fasting; Food; Gastric Mucosa; Intestinal Mucosa; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Parietal Cells, Gastric; Polyamines; Rats; Rats, Inbred Strains | 1986 |
Putrescine does not mediate the androgen-response in mouse kidney.
Topics: Animals; Eflornithine; Female; Kidney; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; RNA, Messenger; Spermidine; Spermine; Testosterone | 1986 |
Effects of certain 5'-substituted adenosines on polyamine synthesis: selective inhibitors of spermine synthase.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cells, Cultured; Eflornithine; Escherichia coli; Kinetics; Mice; Ornithine; Polyamines; S-Adenosylmethionine; Spermidine Synthase; Spermine Synthase; Structure-Activity Relationship; Transferases | 1986 |
Difluoromethylornithine and leukocyte interferon: a phase I study in cancer patients.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Eflornithine; Female; Gastrointestinal Diseases; Humans; Interferon Type I; Male; Melanoma; Middle Aged; Ornithine; Skin Neoplasms; Thrombocytopenia | 1986 |
Potentiation by retinoic acid of ornithine decarboxylase induction by phytohemagglutinin or phorbol 12-myristate 13-acetate in guinea pig lymphocytes.
Topics: Animals; Diterpenes; DNA; Drug Synergism; Eflornithine; Enzyme Induction; Guinea Pigs; In Vitro Techniques; Leucine; Lymphocytes; Ornithine; Ornithine Decarboxylase; Phorbols; Phytohemagglutinins; Polyamines; Retinyl Esters; Tetradecanoylphorbol Acetate; Time Factors; Tretinoin; Vitamin A | 1986 |
Spermidine N1-acetyltransferase has a larger role than ornithine decarboxylase in 1 alpha,25-dihydroxyvitamin D3-induced putrescine synthesis.
Topics: Acetyltransferases; Animals; Calcitriol; Chickens; Duodenum; Eflornithine; Epithelium; Intestinal Mucosa; Kinetics; Male; Ornithine; Ornithine Decarboxylase; Putrescine; Vitamin D Deficiency | 1986 |
Effect of putrescine on the respiration of Trypanosoma brucei brucei.
Topics: Animals; Eflornithine; Magnesium; Male; Mitochondria; Ornithine; Oxygen Consumption; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Trypanosoma brucei brucei | 1986 |
Polyamine-mediated turnover of ornithine decarboxylase in Chinese-hamster ovary cells.
Topics: Animals; Cells, Cultured; Chemical Precipitation; Cricetinae; Cricetulus; Eflornithine; Female; Immunoelectrophoresis; Ornithine; Ornithine Decarboxylase; Ovary; Peptide Fragments; Putrescine; Spermidine | 1986 |
Ornithine decarboxylase activity and actin polymerization in testosterone--stimulated mouse kidney.
Topics: Actins; Animals; Eflornithine; Female; In Vitro Techniques; Kidney; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Stimulation, Chemical; Testosterone | 1986 |
Uterine arginase inhibition affect the rat embryonic development.
Topics: Animals; Arginase; Eflornithine; Embryo Implantation; Embryonic and Fetal Development; Female; Ornithine; Ornithine Decarboxylase; Pregnancy; Rats; Uterus | 1986 |
A Trypanosoma brucei mutant resistant to alpha-difluoromethylornithine.
Topics: Animals; Arginine; Drug Resistance; Eflornithine; Mutation; Ornithine; Ornithine Decarboxylase; Putrescine; Trypanosoma brucei brucei | 1987 |
Effect of dietary methionine, arginine and ornithine on the metabolism and accumulation of polyamines, S-adenosylmethionine and macromolecules in rat liver and skeletal muscle.
Topics: Amino Acids; Animals; Arginine; Body Weight; Diet; Eflornithine; Liver; Macromolecular Substances; Methionine; Muscles; Ornithine; Polyamines; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1987 |
Resolution of the enantiomers of various alpha-substituted ornithine and lysine analogs by high-performance liquid chromatography with chiral eluant and by gas chromatography on Chirasil-Val.
Topics: Chromatography, Gas; Chromatography, High Pressure Liquid; Copper; Eflornithine; Indicators and Reagents; Lysine; Organic Chemicals; Ornithine; Ornithine Decarboxylase Inhibitors; Stereoisomerism | 1987 |
Tumor uptake studies of D,L-[5-14C]ornithine and D,L-2-difluoromethyl [5-14C]ornithine.
Topics: Animals; Carbon Radioisotopes; Eflornithine; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Ornithine; Tissue Distribution; Tomography, Emission-Computed | 1988 |
Effect of alpha-difluoromethylornithine in lung metastases before and after surgery of primary adenocarcinoma tumors in mice.
Topics: Adenocarcinoma; Animals; Eflornithine; Lung; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Ornithine; Polyamines | 1985 |
Inhibition of ornithine decarboxylase by retinoic acid and difluoromethylornithine in relation to their effects on differentiation and proliferation.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Eflornithine; Fibroblasts; Kinetics; Mice; Mice, Inbred BALB C; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Teratoma; Tretinoin | 1985 |
The response of several murine embryonal carcinoma cell lines to stimulation of differentiation by alpha-difluoromethylornithine.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Eflornithine; Embryonal Carcinoma Stem Cells; Fluorescent Antibody Technique; Mice; Neoplastic Stem Cells; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Teratoma | 1985 |
Trypanosomiasis research.
Topics: Africa; Animals; Animals, Domestic; Central America; Eflornithine; Ornithine; Research; South America; Trypanosomiasis | 1985 |
Modification of uptake and antiproliferative effect of methylglyoxal bis(guanylhydrazone) by treatment with alpha-difluoromethylornithine in rodent cell lines with different sensitivities to methylglyoxal bis(guanylhydrazone).
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Line; Eflornithine; Guanidines; Kinetics; Mitochondria; Mitoguazone; Ornithine; Putrescine; Pyruvates; Pyruvic Acid; Rats; Spermidine; Temperature; Time Factors | 1985 |
Inhibition of carcinogenesis by alpha-difluoromethylornithine in heterotopically transplanted rat urinary bladders.
Topics: Animals; Eflornithine; Male; Methylnitrosourea; Ornithine; Putrescine; Rats; Rats, Inbred F344; Spermidine; Spermine; Urinary Bladder; Urinary Bladder Neoplasms | 1985 |
Enhancement of the antiproliferative activity of human interferon by polyamine depletion.
Topics: Aspirin; Cell Division; Cell Line; Doxorubicin; Drug Synergism; Eflornithine; Humans; Indomethacin; Interferon Type I; Neoplasms; Ornithine; Polyamines; Putrescine; Tumor Stem Cell Assay | 1985 |
alpha-Difluoromethylornithine inhibits cell growth stimulated by a tumor-promoting rat urinary fraction.
Topics: Animals; Carcinogens; Cell Line; DNA, Neoplasm; Eflornithine; Ornithine; Ornithine Decarboxylase; Polyamines; Rats; Urinary Bladder Neoplasms; Urine | 1985 |
Requirement of spermidine for induction of both heme synthesis and globin transcription in murine erythroleukemia cells.
Topics: Animals; Cell Division; Dexamethasone; Dimethyl Sulfoxide; Eflornithine; Globins; Heme; Leukemia, Erythroblastic, Acute; Mice; Ornithine; Spermidine; Tetradecanoylphorbol Acetate; Transcription, Genetic | 1985 |
A human neuroblastoma cell line with a stable ornithine decarboxylase in vivo and in vitro.
Topics: Adenosylmethionine Decarboxylase; Adolescent; Animals; Cell Line; Eflornithine; Female; Half-Life; Humans; Liver; Neuroblastoma; Ornithine; Ornithine Decarboxylase; Rats; Rats, Inbred Strains | 1985 |
Effect of concentration of D,L-2-difluoromethylornithine on murine mammary carcinogenesis.
Topics: Animals; Antineoplastic Agents; Eflornithine; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Ornithine; Putrescine; Rats; Rats, Inbred Strains | 1985 |
Accumulation of ornithine decarboxylase-antizyme complex in HMOA cells.
Topics: Animals; Cells, Cultured; Chemical Precipitation; Chromatography, Gel; Cycloheximide; Eflornithine; Liver Neoplasms, Experimental; Methods; Ornithine; Ornithine Decarboxylase Inhibitors; Proteins; Putrescine; Rats | 1985 |
Effects of inhibitors of polyamine biosynthesis on the growth and melanogenesis of murine melanoma cells.
Topics: Animals; Cell Division; Cells, Cultured; Eflornithine; Guanidines; Melanins; Melanoma; Mice; Mitoguazone; Monophenol Monooxygenase; Ornithine; Polyamines | 1985 |
Platelet derived growth factor induces ornithine decarboxylase activity in NIH 3T3 cells.
Topics: Animals; Cell Line; Eflornithine; Enzyme Induction; Mice; Mitosis; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Platelet-Derived Growth Factor; Thymidine | 1985 |
Biological properties of N4- and N1,N8-spermidine derivatives in cultured L1210 leukemia cells.
Topics: Animals; Cells, Cultured; Eflornithine; Kinetics; Leukemia L1210; Mice; Ornithine; Polyamines; Spermidine; Structure-Activity Relationship | 1985 |
Chemosensitization of cultured human carcinoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by difluoromethylornithine-induced polyamine depletion.
Topics: Carmustine; Cell Division; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Eflornithine; Humans; Neoplasms; Ornithine; Ornithine Decarboxylase; Polyamines | 1985 |
Role of polyamines in estradiol-induced growth of human breast cancer cells.
Topics: Breast Neoplasms; Cell Line; Eflornithine; Estradiol; Female; Humans; Ornithine; Ornithine Decarboxylase; Polyamines | 1985 |
Effect of pretreatment with alpha-difluoromethylornithine on the selectivity of methylglyoxal bis(guanylhydrazone) for tumor tissue in L1210 leukemic mice.
Topics: Animals; Carbon Radioisotopes; Drug Therapy, Combination; Eflornithine; Female; Guanidines; Leukemia L1210; Mice; Mice, Inbred DBA; Mitoguazone; Ornithine | 1985 |
Retinoids antagonize the induction of ornithine decarboxylase activity by phorbol esters and phospholipase C in rat tracheal epithelial cells.
Topics: Animals; Cycloheximide; Eflornithine; Epithelial Cells; Epithelium; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Phorbol Esters; Phorbols; Phospholipases; Rats; Receptors, Drug; Retinoids; Structure-Activity Relationship; Tetradecanoylphorbol Acetate; Trachea; Type C Phospholipases | 1985 |
Polyamine reutilization and turnover in brain.
Topics: Alkynes; Aminocaproates; Animals; Brain; Brain Chemistry; Eflornithine; Male; Mice; Ornithine; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Spermidine; Spermine; Vigabatrin | 1985 |
Catalytic irreversible inhibition of Trypanosoma brucei brucei ornithine decarboxylase by substrate and product analogs and their effects on murine trypanosomiasis.
Topics: Animals; Eflornithine; Kinetics; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1985 |
Potentiation by alpha-difluoromethylornithine of the activity of 3,4-dihydroxybenzylamine, a tyrosinase-dependent melanolytic agent, against B16 melanoma.
Topics: Catechol Oxidase; Cells, Cultured; Dopamine; Drug Synergism; Eflornithine; Humans; Melanoma; Monophenol Monooxygenase; Ornithine; Ornithine Decarboxylase Inhibitors | 1985 |
Antitumor effects of two polyamine antimetabolites combined with mitomycin C on human stomach cancer cells xenotransplanted into nude mice.
Topics: Adenocarcinoma, Papillary; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; DNA; Eflornithine; Humans; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Mitomycin; Mitomycins; Ornithine; Polyamines; Stomach Neoplasms | 1985 |
Amplification of ornithine decarboxylase gene in response to polyamine deprivation in Chinese hamster ovary cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Cadaverine; Cell Line; Cricetinae; Cricetulus; Eflornithine; Electrophoresis, Polyacrylamide Gel; Female; Gene Amplification; Karyotyping; Kinetics; Lysine; Ornithine; Ornithine Decarboxylase; Ovary; Plasmids; Polyamines; RNA, Messenger; Spermine | 1985 |
Effect of difluoromethylornithine on host and tumor polyamine metabolism during total parenteral nutrition.
Topics: Animals; Eflornithine; Erythrocytes; Fibrosarcoma; Liver; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Parenteral Nutrition; Parenteral Nutrition, Total; Polyamines; Rats; Rats, Inbred F344; Serum Albumin | 1985 |
Impaired development of cerebellar cortex in rats treated postnatally with alpha-difluoromethylornithine.
Topics: Animals; Cell Count; Cell Differentiation; Cerebellar Cortex; Eflornithine; Female; Hippocampus; Male; Mitosis; Ornithine; Polyamines; Purkinje Cells; Rats; Rats, Inbred Strains | 1985 |
Hormones and polyamines in intestinal and pancreatic adaptation.
Topics: Adaptation, Physiological; Amine Oxidase (Copper-Containing); Animals; Biliary Tract; Cholecystokinin; Eflornithine; Glucagon-Like Peptides; Hyperplasia; Intestinal Mucosa; Models, Biological; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pancreas; Polyamines; Rats | 1985 |
Convulsive syndrome induced by the intracerebroventricular injection of alpha-difluoromethylornithine in rats.
Topics: Animals; Behavior, Animal; Brain; Dose-Response Relationship, Drug; Eflornithine; Female; Injections, Intraventricular; Ornithine; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred Strains; Seizures | 1985 |
Ornithine decarboxylase modification and polyamine-stimulated enzyme inactivation in HTC cells.
Topics: Animals; Cell Line; Chromatography, Gel; Chromatography, Ion Exchange; Cycloheximide; Eflornithine; Isoenzymes; Mitoguazone; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Spermidine | 1985 |
Cytotoxic activity of aziridinyl putrescine enhanced by polyamine depletion with alpha-difluoromethylornithine.
Topics: Antineoplastic Agents; Cell Line; Eflornithine; Humans; Male; Ornithine; Polyamines; Prostatic Neoplasms; Putrescine | 1985 |
Polyamines and estrogen control of growth of the NMU-induced rat mammary tumor.
Topics: Animals; Body Weight; Cell Division; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Estradiol; Estrogens; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Mitoguazone; Nitrosourea Compounds; Ornithine; Ornithine Decarboxylase; Polyamines; Rats; Rats, Inbred Strains; Tamoxifen | 1985 |
Independent regulation of ornithine decarboxylase and S-adenosylmethionine decarboxylase in methylthioadenosine phosphorylase-deficient malignant murine lymphoblasts.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Line; Deoxyadenosines; Eflornithine; Lymphoma; Mice; Ornithine; Ornithine Decarboxylase; Pentosyltransferases; Polyamines; Purine-Nucleoside Phosphorylase; Thionucleosides | 1985 |
Regulation of S-adenosylmethionine decarboxylase activity in rat liver and prostate.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cycloheximide; Eflornithine; Half-Life; Immunosorbent Techniques; Kinetics; Liver; Male; Mitoguazone; Molecular Weight; Ornithine; Prostate; Putrescine; Rabbits; Radioimmunoassay; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1985 |
Ornithine decarboxylase of Plasmodium falciparum: a peak-function enzyme and its inhibition by chloroquine.
Topics: Animals; Chloroquine; Drug Interactions; Eflornithine; Hydrogen-Ion Concentration; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plasmodium falciparum; Putrescine; Spermidine | 1985 |
Effect of 1,25-dihydroxyvitamin D on S-adenosylmethionine decarboxylase in chick intestine.
Topics: Adenosylmethionine Decarboxylase; Animals; Calcitriol; Calcium; Carboxy-Lyases; Chickens; Dactinomycin; Dose-Response Relationship, Drug; Duodenum; Eflornithine; Enzyme Induction; Intestinal Absorption; Intestinal Mucosa; Kinetics; Mitoguazone; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Spermine; Steroids | 1985 |
Effects of dicyclohexylamine sulfate, a spermidine synthase inhibitor, in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Cycle; Cell Survival; Cyclohexylamines; Eflornithine; Mitoguazone; Ornithine; Polyamines; Putrescine; Rats; Spermidine Synthase; Transferases | 1985 |
Effect of inhibition of polyamine biosynthesis by DL-alpha-difluoromethylornithine on the growth and melanogenesis of B16 melanoma in vitro and in vivo.
Topics: Animals; Cell Division; Cells, Cultured; Eflornithine; Male; Melanins; Melanoma; Mice; Mice, Inbred C57BL; Monophenol Monooxygenase; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1985 |
The in vitro interaction of alpha-difluoromethyl ornithine (DFMO) and several interferons on human cell lines.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Division; Cell Line; Cell Survival; Drug Interactions; Eflornithine; Female; Humans; Interferon Type I; Interferon-gamma; Melanoma; Ornithine; Putrescine | 1985 |
Human renal cell carcinoma xenograft: morphology, growth and chemosensitivities.
Topics: Aged; Animals; Antibodies, Monoclonal; Antigens, Neoplasm; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Eflornithine; Humans; Interferon Type I; Kidney Neoplasms; Male; Mice; Mice, Nude; Microscopy, Electron; Neoplasm Transplantation; Ornithine; Transplantation, Heterologous; Tumor Stem Cell Assay | 1985 |
Ornithine decarboxylase inhibitors increase the cellular content of the enzyme: implications for translational regulation.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Line; Cycloheximide; DNA; Eflornithine; Half-Life; Nucleic Acid Hybridization; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; RNA, Messenger | 1985 |
Consequences of ornithine decarboxylase inactivation by alpha-difluoromethylornithine and 5-fluorouracil on the growth of rabbit fibroblasts.
Topics: Animals; Cell Division; Cells, Cultured; Eflornithine; Enzyme Activation; Fibroblasts; Fluorouracil; Ornithine; Ornithine Decarboxylase Inhibitors; Rabbits; Skin | 1985 |
Polyamine depletion results in impairment of polyribosome formation and protein synthesis before onset of DNA synthesis in mitogen-activated human lymphocytes.
Topics: DNA; DNA Replication; Eflornithine; Humans; Lymphocyte Activation; Lymphocytes; Mitogens; Ornithine; Polyamines; Polyribosomes; Protein Biosynthesis; RNA, Messenger; RNA, Ribosomal | 1985 |
Induction of F9 embryonal carcinoma cell differentiation by inhibition of polyamine synthesis.
Topics: Animals; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; Cells, Cultured; Chromatography, Thin Layer; Eflornithine; Embryonal Carcinoma Stem Cells; Mice; Neoplastic Stem Cells; Ornithine; Ornithine Decarboxylase; Plasminogen Activators; Polyamines; Putrescine; Teratoma; Tretinoin | 1985 |
Equilibrium between active and inactive forms of rat liver ornithine decarboxylase mediated by L-ornithine and salts.
Topics: Animals; Catalysis; Eflornithine; Enzyme Activation; Liver; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Osmolar Concentration; Rats; Rats, Inbred Strains; Sodium Chloride | 1985 |
Alterations in polyamine metabolism during embryonal carcinoma cell differentiation in vitro.
Topics: Animals; Cell Differentiation; Cell Line; Eflornithine; Kinetics; Mice; Ornithine; Ornithine Decarboxylase; Polyamines; Teratoma; Tretinoin | 1985 |
Difluoromethylornithine and formycin B in toxoplasmosis.
Topics: Animals; Antibiotics, Antineoplastic; Eflornithine; Formycins; Mice; Ornithine; Toxoplasmosis, Animal | 1985 |
Disruption of the blood-brain barrier in hyperammonemic coma and the pharmacologic effects of dexamethasone and difluoromethyl ornithine.
Topics: Acetates; Ammonia; Animals; Blood-Brain Barrier; Coma; Dexamethasone; Eflornithine; Exploratory Behavior; Female; Grooming; Hepatic Encephalopathy; Mice; Mice, Inbred Strains; Ornithine | 1985 |
Prevention of a plant disease by specific inhibition of fungal polyamine biosynthesis.
Topics: Arginine; Basidiomycota; Eflornithine; Fabaceae; Ornithine; Ornithine Decarboxylase Inhibitors; Plant Diseases; Plants; Plants, Medicinal; Polyamines | 1985 |
Prolactin stimulation of Nb 2 node lymphoma cell division is inhibited by polyamine biosynthesis inhibitors.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cell Line; Drug Interactions; Eflornithine; Lymphoma; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prolactin; Rats | 1985 |
[Potential adaptation of the gastrointestinal system. Existence of an enteropancreatic trophic axis, the role of hormones and polyamines].
Topics: Adaptation, Physiological; Animals; Cholecystokinin; Digestive System Physiological Phenomena; Dogs; Eflornithine; Gastrointestinal Hormones; Glucagon-Like Peptides; Humans; Nutritional Physiological Phenomena; Ornithine; Ornithine Decarboxylase Inhibitors; Pancreas; Polyamines; Rats | 1985 |
Suppression of polyamine biosynthesis prevents monocrotaline-induced pulmonary edema and arterial medial thickening.
Topics: Animals; Biotransformation; Eflornithine; Liver; Lung; Male; Monocrotaline; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Pulmonary Artery; Pulmonary Edema; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains | 1985 |
Purification and properties of ornithine decarboxylase from Tetrahymena pyriformis.
Topics: Animals; Antigen-Antibody Complex; Cell Nucleus; Cytosol; Eflornithine; Half-Life; Immune Sera; Kinetics; Molecular Weight; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Tetrahymena pyriformis | 1985 |
Inhibition of ornithine decarboxylase activity by small doses of alpha-difluoromethylornithine.
Topics: Animals; Dose-Response Relationship, Drug; Eflornithine; Kidney; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Skin; Tetradecanoylphorbol Acetate | 1985 |
Effects of difluoromethylornithine on proliferation, polyamine content and plating efficiency of cultured human carcinoma cells.
Topics: Cell Division; Cell Line; Clone Cells; Eflornithine; Female; Humans; Kinetics; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1985 |
TPA induces differentiation of purified human myeloblasts in the absence of proliferation.
Topics: Bone Marrow; Bone Marrow Cells; Cell Differentiation; Cell Division; Colony-Stimulating Factors; DNA Replication; Eflornithine; Hematopoietic Stem Cells; Humans; Ornithine; Phorbols; Rosette Formation; Tetradecanoylphorbol Acetate; Thymidine; Tritium | 1985 |
Reversal of alpha-difluoromethylornithine inhibition of caerulein-induced pancreatic growth by putrescine.
Topics: Animals; Body Weight; Ceruletide; DNA; DNA Replication; Eflornithine; Male; Organ Size; Ornithine; Ornithine Decarboxylase Inhibitors; Pancreas; Putrescine; Rats; Rats, Inbred Strains | 1985 |
The effect of combination treatment with alpha-difluoromethylornithine and Corynebacterium parvum on B16 melanoma growth and tumoricidal effector cell generation in vivo.
Topics: Animals; Eflornithine; Immunity, Cellular; Immunity, Innate; Immunotherapy; Killer Cells, Natural; Macrophages; Male; Melanoma; Mice; Mice, Inbred C57BL; Ornithine; Polyamines; Propionibacterium acnes; Spleen | 1985 |
Phase I evaluation of intravenous difluoromethylornithine--a polyamine inhibitor.
Topics: Acute Disease; Adolescent; Adult; Aged; Antineoplastic Agents; Drug Evaluation; Eflornithine; Humans; Infusions, Parenteral; Leukemia; Leukocyte Count; Male; Middle Aged; Ornithine; Polyamines; Time Factors | 1985 |
Translational regulation of mammalian ornithine decarboxylase by polyamines.
Topics: Animals; Cell Line; Drug Resistance; Eflornithine; Mice; Multiple Myeloma; Ornithine; Ornithine Decarboxylase; Polyamines; Protein Biosynthesis; Putrescine; RNA, Messenger | 1985 |
Inhibition of ornithine decarboxylase activity and cell growth by diamines: a comparison between the effects of two homologs, 1,3-diaminopropane and 1,4-diaminobutane (putrescine).
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Diamines; Eflornithine; Flow Cytometry; Kinetics; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine | 1985 |
Regulation of epidermal proliferation in mouse epidermis by combination of difluoromethyl ornithine (DFMO) and methylglyoxal bis(guanylhydrazone) (MGBG).
Topics: Animals; DNA; Drug Combinations; Eflornithine; Epidermis; Growth; Mice; Mitoguazone; Ornithine; Polyamines; Skin | 1985 |
[Polyamines, polyamine antimetabolites and urogenital tumors. State of research and clinical results].
Topics: Adenosylmethionine Decarboxylase; Antimetabolites, Antineoplastic; Carboxy-Lyases; Drug Combinations; Eflornithine; Enzyme Induction; Enzyme Inhibitors; Humans; Kidney Neoplasms; Male; Mitoguazone; Ornithine; Polyamines; Prostatic Neoplasms; Urogenital Neoplasms | 1985 |
Ornithine decarboxylase activity in human endometrium and endometrial cancer cells.
Topics: Adenocarcinoma; Cell Division; Cell Line; Corpus Luteum; Cycloheximide; Dactinomycin; Eflornithine; Endometrium; Female; Follicular Phase; Humans; Molybdenum; Ornithine; Ornithine Decarboxylase; Progesterone; Putrescine; Time Factors; Uterine Neoplasms | 1985 |
alpha-Difluoromethylornithine, an inhibitor of polyamine synthesis, attenuates monocrotaline-induced pulmonary vascular hyperresponsiveness in isolated perfused rat lungs.
Topics: Angiotensin II; Animals; Blood Pressure; Eflornithine; Enzyme Activation; In Vitro Techniques; Lung; Male; Monocrotaline; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Potassium Chloride; Pulmonary Artery; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Vasoconstriction | 1985 |
Method of testing the susceptibility of Pneumocystis carinii to antimicrobial agents in vitro.
Topics: Animals; Cells, Cultured; Dapsone; Drug Combinations; Eflornithine; Lung; Male; Ornithine; Pentamidine; Pneumocystis; Rats; Rats, Inbred Strains; Sulfamethoxazole; Trimethoprim; Trimethoprim, Sulfamethoxazole Drug Combination | 1985 |
Pharmacokinetic approaches to drug distribution in the cerebrospinal fluid based on ventricular administration in beagle dogs.
Topics: Animals; Brain Chemistry; Dogs; Eflornithine; Half-Life; Injections, Intraventricular; Inulin; Kinetics; Male; Mitoguazone; Models, Biological; Nimustine; Nitrosourea Compounds; Ornithine; Pharmaceutical Preparations | 1985 |
Effect of estrogen and androgen administration on alpha-difluoromethylornithine-enhanced putrescine uptake by the rat prostate.
Topics: Animals; Diethylstilbestrol; Dihydrotestosterone; Eflornithine; Male; Ornithine; Polyamines; Prostate; Putrescine; Rats; Rats, Inbred Strains | 1985 |
Gene expression of ornithine decarboxylase in L1210 leukaemia cells exposed to DL-2-difluoromethylornithine in the presence of cadaverine.
Topics: Animals; Cadaverine; Cells, Cultured; Diamines; DNA, Neoplasm; Eflornithine; Gene Amplification; Gene Expression Regulation; Leukemia L1210; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; RNA, Messenger | 1985 |
[African trypanosomiasis of icterohemorrhagic form].
Topics: Eflornithine; France; Male; Ornithine; Tanzania; Travel; Trypanocidal Agents; Trypanosomiasis, African | 1985 |
Effects of alpha-difluoromethylornithine on pancreatic growth induced by caerulein.
Topics: Amylases; Animals; Ceruletide; DNA; DNA Replication; Drug Interactions; Eflornithine; Kinetics; Male; Organ Size; Ornithine; Ornithine Decarboxylase Inhibitors; Pancreas; Rats; Rats, Inbred Strains; RNA | 1984 |
Effect of alpha-difluoromethylornithine (DFMO) on the behavioral syndrome induced by intracerebroventricular injection of ACTH 1-24, in rats.
Topics: Adrenocorticotropic Hormone; Animals; Cosyntropin; Eflornithine; Humans; Injections, Intraventricular; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Penis; Rats; Rats, Inbred Strains; Sexual Behavior, Animal; Stereotyped Behavior | 1984 |
Impaired development of central and peripheral catecholamine neurotransmitter systems in preweanling rats treated with alpha-difluoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Animals, Newborn; Brain; Carboxy-Lyases; Dopamine; Eflornithine; Female; Neurons; Neurotransmitter Agents; Norepinephrine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Rats; Rats, Inbred Strains; Receptors, Neurotransmitter; Sympathetic Nervous System; Tyrosine 3-Monooxygenase | 1982 |
The competitive inhibition of tissue transglutaminase by alpha-difluoromethylornithine.
Topics: Acyltransferases; Animals; Caseins; Eflornithine; Guinea Pigs; Kinetics; Liver; Ornithine; Putrescine; Transglutaminases | 1984 |
Enhancement of phenotypic instability by alpha-difluoromethylornithine and butylated hydroxyanisole in rapidly induced rat liver lesions.
Topics: 2-Acetylaminofluorene; Animals; Anisoles; Butylated Hydroxyanisole; Diethylnitrosamine; Eflornithine; gamma-Glutamyltransferase; Glucosephosphate Dehydrogenase; Liver; Liver Neoplasms, Experimental; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Phenobarbital; Phenotype; Rats; Rats, Inbred F344; Stimulation, Chemical; Time Factors | 1984 |
Increased rate of tumor cell death caused by polyamine synthesis inhibitors.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Division; Cell Survival; Eflornithine; Guanidines; Male; Mice; Mice, Inbred Strains; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1984 |
Host liver changes in leukemic mice: effect of alpha-difluoromethyl ornithine, an inhibitor of polyamine synthesis.
Topics: Animals; beta-N-Acetylhexosaminidases; Eflornithine; Female; gamma-Glutamyltransferase; Glutathione; Hexosaminidases; Leukemia P388; Leukemia, Experimental; Liver; Mice; Mice, Inbred DBA; Ornithine; Polyamines; Proline | 1984 |
The effect of alpha-difluoromethyl-ornithine on tumor growth, acute phase reactants, beta-2-microglobulin and hydroxyproline in kidney and bladder carcinomas.
Topics: 17-Ketosteroids; Adenocarcinoma; Adult; Aged; alpha 1-Antitrypsin; Antineoplastic Agents; beta 2-Microglobulin; Beta-Globulins; Eflornithine; Estrogens; Female; Haptoglobins; Humans; Hydroxyproline; Kidney Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Ornithine; Ornithine Decarboxylase Inhibitors; Testosterone; Transferrin; Urinary Bladder Neoplasms | 1981 |
Further studies on difluoromethylornithine in African trypanosomes.
Topics: Acute Disease; Animals; Arvicolinae; Bleomycin; Carboxy-Lyases; Central Nervous System Diseases; Chronic Disease; Drug Therapy, Combination; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1981 |
Effect on prostatic growth of 2-difluoromethylornithine, an effective inhibitor of ornithine decarboxylase.
Topics: Animals; Carboxy-Lyases; DNA; Eflornithine; Male; Organ Size; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prostate; Rats; Rats, Inbred Strains; RNA | 1982 |
Methylglyoxal BIS (guanylhydrazone) and alpha-difluoromethylornithine-induced polyamine deprivation in psoriatic lesions.
Topics: Carboxy-Lyases; Dose-Response Relationship, Drug; Eflornithine; Guanidines; Humans; Injections, Intradermal; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Psoriasis; Putrescine; Skin; Spermidine; Spermine | 1982 |
The effect of alpha-difluoromethylornithine on the development of bleomycin-induced pulmonary fibrosis in hamsters.
Topics: Animals; Bleomycin; Collagen; Cricetinae; Eflornithine; Lung; Mesocricetus; Ornithine; Pulmonary Fibrosis | 1982 |
Novel combination chemotherapy of experimental trypanosomiasis by using bleomycin and DL-alpha-difluoromethylornithine; reversal by polyamines.
Topics: Animals; Bleomycin; Drug Therapy, Combination; Eflornithine; Mice; Ornithine; Polyamines; Time Factors; Trypanosoma brucei brucei; Trypanosomiasis, African | 1982 |
Tumor suppression with a combination of alpha-difluoromethyl ornithine and interferon.
Topics: Animals; Cells, Cultured; Eflornithine; Interferons; Melanoma; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors | 1983 |
Epidermal keratinocytes actively maintain their intracellular polyamine levels.
Topics: Animals; Biological Transport; Cell Division; Cells, Cultured; Culture Media; Eflornithine; Epidermal Cells; Epidermis; Keratins; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
In vivo effects of alpha-DL-difluoromethylornithine on the metabolism and morphology of Trypanosoma brucei brucei.
Topics: Animals; DNA; Eflornithine; Female; Kinetics; Macromolecular Substances; Ornithine; Polyamines; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA; Trypanosoma brucei brucei; Trypanosomiasis, African | 1983 |
Efficacy of combinations of difluoromethylornithine and bleomycin in a mouse model of central nervous system African trypanosomiasis.
Topics: Animals; Bleomycin; Central Nervous System Diseases; Disease Models, Animal; Drug Therapy, Combination; Eflornithine; Female; Male; Mice; Ornithine; Spermidine; Spermine; Trypanocidal Agents; Trypanosomiasis, African | 1983 |
Studies of the effects of alpha-difluoromethylornithine and ethanol on the pathogenesis of bleomycin-induced pulmonary fibrosis in mice.
Topics: Animals; Bleomycin; Eflornithine; Ethanol; Fibroblasts; Lung; Male; Mice; Mice, Inbred DBA; Microsomes; Ornithine; Pulmonary Fibrosis | 1983 |
Effect of polyamine antimetabolites on cultured human keratinocytes from normal and uninvolved psoriatic skin.
Topics: Antimetabolites; Cell Division; Cells, Cultured; DNA; Eflornithine; Guanidines; Humans; Keratins; Mitoguazone; Ornithine; Protein Biosynthesis; Psoriasis; Putrescine; Skin; Spermidine; Spermine | 1984 |
Control of nucleic acid and protein synthesis in developing brain, kidney, and heart of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Animals, Newborn; Brain; Cell Survival; DNA; Eflornithine; Heart; Kidney; Myocardium; Nerve Tissue Proteins; Ornithine; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; Rats; Rats, Inbred Strains; RNA | 1984 |
Polyamines and the development of isolated neurons in cell culture.
Topics: Alkynes; Animals; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Chick Embryo; Diamines; Eflornithine; Nerve Tissue Proteins; Neurons; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; RNA | 1984 |
Role of polyamines in isoproterenol-induced cardiac hypertrophy: effects of alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Cardiomegaly; Eflornithine; Isoproterenol; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains | 1982 |
Regulation of hematopoiesis II: the role of polyamine inhibition on helper or suppressor influences of the thymus.
Topics: Animals; Bone Marrow Cells; Colony-Forming Units Assay; Eflornithine; Erythrocytes; Hematopoiesis; Male; Mice; Ornithine; Polyamines; Putrescine; Spleen; T-Lymphocytes, Helper-Inducer; T-Lymphocytes, Regulatory; Thymus Gland | 1983 |
Lack of correlation between liver RNA polymerase I and ornithine decarboxylase activities after re-feeding of protein-depleted mice.
Topics: Animals; Diet; Eflornithine; Liver; Male; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Deficiency; RNA Polymerase I | 1984 |
Inhibition of Semliki Forest and herpes simplex virus production in alpha-difluoromethylornithine-treated cells: reversal by polyamines.
Topics: Animals; Cell Line; Cricetinae; Eflornithine; Kidney; Ornithine; Polyamines; Semliki forest virus; Simplexvirus; Virus Replication | 1980 |
Polyamines are necessary for the survival of human small-cell lung carcinoma in culture.
Topics: Carcinoma, Small Cell; Cell Aggregation; Cell Division; Cell Survival; Cells, Cultured; Eflornithine; Humans; Lung Neoplasms; Ornithine; Polyamines; Putrescine | 1981 |
Temperature-dependent and transformation-associated changes in polyamine metabolism in normal and Rous sarcoma virus-infected chick embryo fibroblasts.
Topics: Animals; Avian Sarcoma Viruses; Cell Transformation, Viral; Chick Embryo; Eflornithine; Fibroblasts; Ornithine; Ornithine Decarboxylase; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Putrescine; Spermidine; Spermine; Temperature | 1981 |
Role of polyamines in the proliferation and steroidogenic activities of bovine adrenocortical cells in culture.
Topics: Adrenal Cortex; Animals; Carboxy-Lyases; Cattle; Cell Division; Cells, Cultured; Cosyntropin; Cyclic AMP; Eflornithine; Hydrocortisone; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1981 |
Roles of polyamines in the replication of animal viruses.
Topics: DNA-Directed RNA Polymerases; Eflornithine; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Semliki forest virus; Simplexvirus; Virus Replication | 1981 |
Inhibitors of polyamine biosynthesis block human cytomegalovirus replication.
Topics: Antiviral Agents; Cells, Cultured; Cytomegalovirus; Eflornithine; Guanidines; Humans; Mitoguazone; Ornithine; Polyamines; Spermidine; Spermine; Virus Replication | 1982 |
Growth regulatory effects of cyclic AMP and polyamine depletion are dissociable in cultured mouse lymphoma cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Bucladesine; Cell Division; Cell Line; Cyclic AMP; Eflornithine; Interphase; Lymphoma; Mice; Models, Biological; Ornithine; Ornithine Decarboxylase; Polyamines; Protein Kinases; Putrescine; Spermidine | 1983 |
Effects of inhibitors of ornithine decarboxylase on the differentiation of mouse neuroblastoma cells.
Topics: Acetylcholinesterase; Animals; Bucladesine; Carboxy-Lyases; Cell Differentiation; Drug Synergism; Eflornithine; Mice; Neuroblastoma; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
Effects of alpha-difluoromethylornithine on the growth of experimental Wilms' tumor and renal adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Drug Evaluation, Preclinical; Eflornithine; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Ornithine; Rats; Wilms Tumor | 1983 |
Differential effect of alpha-difluoromethyl-ornithine on the proliferation of Balb 3T3 and chemically transformed 3T3 cells.
Topics: Animals; Benzo(a)pyrene; Benzopyrenes; Carcinogens; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; DNA Replication; Eflornithine; Interphase; Kinetics; Mice; Mice, Inbred BALB C; Ornithine; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; Putrescine; Transcription, Genetic | 1983 |
D,L-alpha-difluoromethylornithine inhibits human cytomegalovirus replication.
Topics: Cells, Cultured; Cytomegalovirus; DNA, Viral; Eflornithine; Humans; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Simplexvirus; Spermidine; Spermine; Viral Proteins; Virion; Virus Replication | 1984 |
Radiochemical determination of polyamines in poliovirus and human rhinovirus 14.
Topics: Eflornithine; HeLa Cells; Humans; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Poliovirus; Putrescine; Rhinovirus; Spermidine; Spermine | 1984 |
Inhibition of growth of Giardia lamblia by difluoromethylornithine, a specific inhibitor of polyamine biosynthesis.
Topics: Animals; Eflornithine; Entamoeba histolytica; Giardia; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Trichomonas vaginalis | 1984 |
Modulation of the tissue disposition of methylglyoxal bis(guanylhydrazone) in mice by polyamine depletion and by polyamine administration.
Topics: Animals; Bone Marrow; Carboxy-Lyases; Eflornithine; Guanidines; Intestine, Small; Liver; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Tissue Distribution | 1983 |
Changes in mouse kidney ornithine decarboxylase activity are brought about by changes in the amount of enzyme protein as measured by radioimmunoassay.
Topics: Animals; Carboxy-Lyases; Cycloheximide; Diamines; Eflornithine; Female; Kidney; Male; Mice; Mice, Inbred BALB C; Models, Biological; Ornithine; Ornithine Decarboxylase; Radioimmunoassay | 1983 |
Antigrowth effect of some inhibitors of polyamine synthesis on transplantable prostate cancer.
Topics: Animals; Body Weight; Drug Therapy, Combination; Eflornithine; Guanidines; Male; Mitoguazone; Neoplasm Transplantation; Neoplasms, Experimental; Ornithine; Polyamines; Prostatic Neoplasms; Rats; Vidarabine | 1983 |
Combined use of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) in normal and leukemia-bearing mice.
Topics: Animals; Antineoplastic Agents; Bone Marrow; Drug Therapy, Combination; Eflornithine; Female; Guanidines; Leukemia L1210; Mice; Mice, Inbred DBA; Mitoguazone; Ornithine; Spleen; Time Factors; Tissue Distribution | 1983 |
Effect of tamoxifen and alpha-difluoromethylornithine on clones of nitrosomethylurea-induced rat mammary tumor cells grown in soft agar culture.
Topics: Agar; Animals; Cells, Cultured; Clone Cells; Dose-Response Relationship, Drug; Eflornithine; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Nitrosourea Compounds; Ornithine; Rats; Rats, Inbred Strains; Tamoxifen | 1983 |
Effects of polyamine limitation on nucleolar development and morphology in early chick embryos.
Topics: Animals; Carboxy-Lyases; Cell Nucleolus; Chick Embryo; Eflornithine; Microscopy, Electron; Mitotic Index; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
Changes in mitochondrial structure and function in 9l rat brain tumor cells treated in vitro with alpha-difluoromethylornithine, a polyamine biosynthesis inhibitor.
Topics: Animals; Brain; Cells, Cultured; Eflornithine; Microscopy, Electron; Mitochondria; Mitoguazone; Ornithine; Polyamines; Pyruvates; Pyruvic Acid; Rats | 1983 |
Microinjection of purified ornithine decarboxylase into Xenopus oocytes selectively stimulates ribosomal RNA synthesis.
Topics: Animals; Carboxy-Lyases; Eflornithine; Female; Guanosine; Microinjections; Oocytes; Ornithine; Ornithine Decarboxylase; Ovum; Putrescine; RNA, Ribosomal; Xenopus laevis | 1983 |
Cell cycle age response of 9L cells to 1,3-bis(2-chloroethyl)-1-nitrosourea and modification by alpha-difluoromethylornithine.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Cycle; Cell Line; Eflornithine; Kinetics; Neoplasms, Experimental; Ornithine; Rats | 1983 |
Divergent effects of ornithine decarboxylase inhibition on murine erythropoietic precursor cell proliferation and differentiation.
Topics: Animals; Bone Marrow; Carboxy-Lyases; Cell Differentiation; Cell Division; Cells, Cultured; Eflornithine; Hematopoietic Stem Cells; Kinetics; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine | 1983 |
Cytotoxicity of methylglyoxal bis(guanylhydrazone) in combination with alpha-difluoromethylornithine against HeLa cells and mouse L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Cell Survival; Drug Synergism; Drug Therapy, Combination; Eflornithine; Female; Guanidines; HeLa Cells; Humans; Leukemia L1210; Mice; Mice, Inbred Strains; Mitoguazone; Neoplasm Transplantation; Ornithine; Polyamines | 1983 |
Tumor selective enhancement of radioactivity uptake in mice treated with alpha-difluoromethylornithine prior to administration of 14C-putrescine.
Topics: Animals; Brain; Carbon Radioisotopes; Eflornithine; Lung; Male; Mice; Mice, Inbred BALB C; Neoplasms, Experimental; Ornithine; Putrescine; Tissue Distribution | 1983 |
Subcellular distribution of ornithine decarboxylase in rat liver and accessibility of the enzyme to alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Carboxy-Lyases; Cell Nucleolus; Cell Nucleus; Cytosol; Dexamethasone; Eflornithine; Enzyme Induction; Hepatectomy; Liver; Male; Ornithine; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Subcellular Fractions | 1983 |
Inhibition of ornithine decarboxylase of in vitro cultured Plasmodium falciparum by chloroquine.
Topics: Carboxy-Lyases; Chloroquine; Culture; DNA; Eflornithine; Humans; Mefloquine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plasmodium falciparum; Quinolines | 1983 |
Discordant regulation by luteinizing hormone of ornithine decarboxylase activity and testosterone production in isolated rat testicular cells in vitro.
Topics: Animals; Carboxy-Lyases; Cells, Cultured; Cycloheximide; Eflornithine; Luteinizing Hormone; Male; Ornithine; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Testis; Testosterone | 1983 |
Inhibition of polyamine synthesis blocks urinary secretion of beta-glucuronidase from mouse kidney.
Topics: Animals; Eflornithine; Enzyme Induction; Glucuronidase; Kidney; Male; Mice; Mitoguazone; Ornithine; Polyamines; Testosterone | 1983 |
Decreased cytotoxicity of 1-beta-D-arabinofuranosylcytosine in 9L rat brain tumor cells pretreated with alpha-difluoromethylornithine in vitro.
Topics: Animals; Brain Neoplasms; Cell Cycle; Cell Survival; Cells, Cultured; Cytarabine; DNA; Drug Synergism; Eflornithine; Ornithine; Rats; Time Factors | 1983 |
Inhibition of ornithine decarboxylase with 2-difluoromethylornithine: reduced incidence of dimethylhydrazine-induced colon tumors in mice.
Topics: 1,2-Dimethylhydrazine; Animals; Carboxy-Lyases; Carcinogens; Cell Survival; Colonic Neoplasms; Dimethylhydrazines; DNA; Eflornithine; Humans; Methylhydrazines; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
Combination chemotherapy involving alpha-difluoromethylornithine and 1-beta-D-arabinofuranosylcytosine in murine L1210 leukemia.
Topics: Animals; Body Weight; Bone Marrow; Bone Marrow Cells; Cell Cycle; Cytarabine; Drug Therapy, Combination; Eflornithine; Erythrocyte Count; Female; Leukemia L1210; Leukocyte Count; Longevity; Mice; Mice, Inbred Strains; Neoplasm Transplantation; Ornithine; Polyamines | 1983 |
Stimulation of melanotic expression in murine melanoma cells exposed to polyamine antimetabolites.
Topics: Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Cell Line; Drug Synergism; Eflornithine; Guanidines; Melanins; Melanocyte-Stimulating Hormones; Melanoma; Mice; Mitoguazone; Monophenol Monooxygenase; Ornithine; Polyamines | 1983 |
Differential potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine in chloroethylnitrosourea-sensitive and -resistant 9L rat brain tumor cells in vitro.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Line; Drug Resistance; Drug Synergism; Eflornithine; Ornithine; Polyamines; Rats; Sister Chromatid Exchange | 1983 |
Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Administration, Oral; Administration, Topical; Animals; Cell Division; Eflornithine; Epidermis; Female; Injections, Intraperitoneal; Mice; Ornithine; Ornithine Decarboxylase; Polyamines; Skin Neoplasms; Tetradecanoylphorbol Acetate | 1983 |
Brain, CSF, and tumor pharmacokinetics of alpha-difluoromethylornithine in rats and dogs.
Topics: Animals; Antineoplastic Agents; Brain; Brain Neoplasms; Cerebrospinal Fluid; Dogs; Eflornithine; Kinetics; Neoplasm Transplantation; Neoplasms, Experimental; Ornithine; Rats; Rats, Inbred F344; Tissue Distribution | 1983 |
Treatment of metastatic Lewis lung carcinoma with DL-alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Eflornithine; Female; Lung; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
Ornithine decarboxylase in difluoromethylornithine-resistant mouse lymphoma cells. Two-dimensional gel analysis of synthesis and turnover.
Topics: Animals; Carboxy-Lyases; Cell Line; Drug Resistance; Eflornithine; Electrophoresis, Polyacrylamide Gel; Kinetics; Lymphoma; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors | 1983 |
Depletion of intracellular polyamines may alter DNA conformation in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; DNA, Neoplasm; Eflornithine; Molecular Conformation; Ornithine; Polyamines; Putrescine; Rats; Spermidine; Viscosity | 1983 |
Experimental chemotherapy in a transplantable renal adenocarcinoma. I: Effects of some inhibitors of polyamine synthesis.
Topics: Adenocarcinoma; Animals; Eflornithine; Guanidines; Kidney; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mitoguazone; Neoplasms, Experimental; Ornithine; Polyamines | 1983 |
Polyamine starvation causes accumulation of cadaverine and its derivatives in a polyamine-dependent strain of Chinese-hamster ovary cells.
Topics: Animals; Cadaverine; Cells, Cultured; Cricetinae; Cricetulus; Diamines; Eflornithine; Female; Ornithine; Ovary; Polyamines; Proteins | 1983 |
Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Cycle; Cell Line; Cell Survival; Eflornithine; Fluorouracil; Humans; Kinetics; Ornithine; Putrescine; Spermidine | 1983 |
Successful treatment with DL-alpha-difluoromethylornithine in established human small cell variant lung carcinoma implants in athymic mice.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Line; Drug Evaluation, Preclinical; Eflornithine; Genetic Variation; Humans; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Ornithine; Transplantation, Heterologous | 1983 |
Inhibition of DNA and protein synthesis in UV-irradiated mouse skin by 2-difluoromethylornithine, methylglyoxal bis(guanylhydrazone), and their combination.
Topics: Animals; DNA Replication; Drug Interactions; Eflornithine; Female; Guanidines; Mice; Mitoguazone; Ornithine; Protein Biosynthesis; Putrescine; Skin; Spermidine; Ultraviolet Rays | 1983 |
Metabolic consequences of inhibition of cerebral adenosylmethionine decarboxylase by methylglyoxal bis(Guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Animals; Brain; Carboxy-Lyases; Eflornithine; Guanidines; Injections, Intraventricular; Male; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase; Polyamines | 1983 |
Polyamine biosynthesis is required for the maintenance of peripheral blood cell elements in the rat.
Topics: Animals; Blood Cell Count; Blood Platelets; Bone Marrow; Carboxy-Lyases; Cytarabine; Eflornithine; Erythrocytes; Female; Leukocytes; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains | 1983 |
Role of diamine oxidase during the treatment of tumour-bearing mice with combinations of polyamine anti-metabolites.
Topics: Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Drug Therapy, Combination; Eflornithine; Female; Guanidines; Leukemia L1210; Mice; Mice, Inbred DBA; Mitoguazone; Ornithine; Polyamines | 1983 |
Inhibition of ornithine decarboxylase induces embryonal carcinoma cell differentiation.
Topics: Animals; Carboxy-Lyases; Cell Differentiation; Cell Line; Eflornithine; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine; Teratoma | 1983 |
Influence of polyamine depletion caused by alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on alkylation- and carbamoylation-induced cytotoxicity in 9L rat brain tumor cells in vitro.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carboxy-Lyases; Carmustine; Cell Line; Cell Survival; Drug Synergism; Eflornithine; Ethylnitrosourea; Lomustine; Methylnitrosourea; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats | 1983 |
Role of polyamines during chromosome condensation of mammalian cells.
Topics: Chromosomes, Human; Eflornithine; HeLa Cells; Humans; Interphase; Mitosis; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
Polyamine depletion inhibits the differentiation of L6 myoblast cells.
Topics: Animals; Carboxy-Lyases; Cell Differentiation; Cell Fusion; Cells, Cultured; Creatine Kinase; Eflornithine; Mice; Muscles; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
Measurement of the amount of ornithine decarboxylase in Saccharomyces cerevisiae and Saccharomyces uvarum by using alpha-[5-14C]difluoromethylornithine.
Topics: Carbon Radioisotopes; Eflornithine; Kinetics; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Binding; Saccharomyces; Saccharomyces cerevisiae; Species Specificity | 1983 |
Plasmodium berghei: inhibition of the sporogonous cycle by alpha-difluoromethylornithine.
Topics: Animals; Anopheles; Eflornithine; Ornithine; Ornithine Decarboxylase Inhibitors; Plasmodium berghei | 1983 |
Autoradiographic localization of ornithine decarboxylase.
Topics: Animals; Autoradiography; Eflornithine; Kidney; Mice; Ornithine; Ornithine Decarboxylase | 1983 |
Labeling and quantitation of ornithine decarboxylase protein by reaction with alpha-[5-14C]difluoromethylornithine.
Topics: Animals; Eflornithine; Kidney; Mice; Ornithine; Ornithine Decarboxylase | 1983 |
Methods for the study of the treatment of protozoan diseases by inhibitors of ornithine decarboxylase.
Topics: Animals; Chickens; Coccidiosis; Eflornithine; Female; Male; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Protozoan Infections; Trypanosomiasis, African | 1983 |
Methods for the study of the experimental interruption of pregnancy by ornithine decarboxylase inhibitors: effects of DL-alpha-difluoromethylornithine.
Topics: Abortifacient Agents; Abortifacient Agents, Nonsteroidal; Animals; Dose-Response Relationship, Drug; Eflornithine; Female; Mice; Mice, Inbred ICR; Ornithine; Ornithine Decarboxylase Inhibitors; Pregnancy; Species Specificity | 1983 |
Sequential inhibition of polyamine synthesis. A phase I trial of DFMO (alpha-difluoromethylornithine) and methyl-GAG [methylglyoxal-bis(guanylhydrazone)].
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Drug Therapy, Combination; Eflornithine; Guanidines; Humans; Middle Aged; Mitoguazone; Neoplasms; Ornithine; Polyamines | 1983 |
Inhibition of rat embryonic development by the intrauterine administration of alpha-difluoromethylornithine.
Topics: Animals; Contraceptives, Postcoital; Contraceptives, Postcoital, Synthetic; Eflornithine; Embryo Implantation; Embryo, Mammalian; Female; Ornithine; Ornithine Decarboxylase Inhibitors; Pregnancy; Putrescine; Rats; Rats, Inbred Strains; Uterus | 1983 |
A mouse lymphoma cell mutant whose major protein product is ornithine decarboxylase.
Topics: Animals; Cell Division; Cell Line; Chromosome Banding; Eflornithine; Karyotyping; Kinetics; Lymphoma; Mice; Mutation; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Biosynthesis; RNA, Messenger | 1983 |
Chinese hamster ovary cells resistant to alpha-difluoromethylornithine are overproducers of ornithine decarboxylase.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Eflornithine; Enzyme Induction; Female; Kinetics; Molecular Weight; Mutation; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ovary | 1983 |
Percutaneous penetration of methylglyoxal bis(guanylhydrazone): effects on hairless mouse epidermis in vivo.
Topics: Administration, Topical; Animals; DNA; Eflornithine; Guanidines; In Vitro Techniques; Mice; Mice, Hairless; Mitoguazone; Ornithine; Polyamines; Psoriasis; Skin; Skin Absorption | 1983 |
Cell cycle phase specificity and therapeutic effectiveness of polyamine synthesis inhibitors.
Topics: Animals; Cell Cycle; Eflornithine; Humans; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1983 |
[Combined antitumor therapy with polyamine biosynthesis inhibitors and mitomycin C].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Eflornithine; Humans; Mice; Mice, Nude; Mitoguazone; Mitomycin; Mitomycins; Neoplasm Transplantation; Ornithine; Stomach Neoplasms | 1983 |
Biochemical and ultrastructural characterization of human cell variants resistant to the antiproliferative effects of methylglyoxal bis(guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Cell Cycle; Cell Line; Drug Resistance; Eflornithine; Genetic Variation; Guanidines; Humans; Kinetics; Lung; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Oxygen Consumption; Pyruvates; Pyruvic Acid | 1983 |
Contragestational effects of DL-alpha-difluoro-methylornithine, an irreversible inhibitor of ornithine decarboxylase, in the hamster.
Topics: Animals; Contraceptives, Postcoital; Contraceptives, Postcoital, Synthetic; Cricetinae; Eflornithine; Female; Mesocricetus; Ornithine; Ornithine Decarboxylase Inhibitors; Pregnancy; Pregnancy, Animal; Time Factors | 1983 |
Intestinal changes caused by DL-alpha-difluoromethylornithine (DFMO), an inhibitor of ornithine decarboxylase.
Topics: Animals; Depression, Chemical; Diarrhea; Dogs; Eflornithine; Female; Intestinal Absorption; Intestinal Mucosa; Macaca fascicularis; Male; Microvilli; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Vomiting | 1983 |
Determination of free and total polyamines in human serum and urine by ion-pairing high-performance liquid chromatography using a radial compression module. Application to blood polyamine determination in cancer patients treated or not treated with an orn
Topics: Aged; Cadaverine; Chromatography, High Pressure Liquid; Eflornithine; Female; Fluorescence; Humans; Male; Middle Aged; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1983 |
alpha-Difluoromethylornithine-induced polyamine depletion of 9L tumor cells modifies drug-induced DNA cross-link formation.
Topics: Animals; Carmustine; Cells, Cultured; Cisplatin; Cross-Linking Reagents; DNA; Eflornithine; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats | 1983 |
Blood brain barrier breakdown in brain edema following cold injury is mediated by microvascular polyamines.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Cerebral Cortex; Cerebrovascular Circulation; Eflornithine; Female; Freezing; Kinetics; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains | 1983 |
Decreased cytotoxicity of aziridinylbenzoquinone caused by polyamine depletion in 9L rat brain tumor cells in vitro.
Topics: Animals; Antineoplastic Agents; Aziridines; Azirines; Benzoquinones; Brain Neoplasms; Cell Line; Cell Survival; Cyclohexenes; Eflornithine; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats | 1984 |
Potentiation of methylglyoxal-bis-guanylhydrazone by alpha-difluoromethylornithine in rat prostate cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cell Line; Drug Synergism; Eflornithine; Guanidines; Humans; Male; Mitoguazone; Neoplasm Transplantation; Ornithine; Prostatic Neoplasms; Rats; Rats, Inbred Strains | 1984 |
Effects of alpha-difluoromethylornithine on the growth of 9L rat brain tumor multicellular spheroids and their response to 1,3-bis(2-chloroethyl)-1-nitrosourea.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Cell Division; Cell Survival; Drug Therapy, Combination; Eflornithine; Ornithine; Polyamines; Rats | 1984 |
Differential effect of alpha-difluoromethylornithine on the in vivo uptake of 14C-labeled polyamines and methylglyoxal bis(guanylhydrazone) by a rat prostate-derived tumor.
Topics: Animals; Antineoplastic Agents; Biological Transport; Carbon Radioisotopes; Cells, Cultured; Eflornithine; Guanidines; Male; Mitoguazone; Ornithine; Polyamines; Prostatic Neoplasms; Putrescine; Rats; Rats, Inbred Strains; Spermidine | 1984 |
Studies of mammalian ornithine decarboxylase using a monoclonal antibody.
Topics: Animals; Antibodies, Monoclonal; Chemical Precipitation; Chromatography, Affinity; Eflornithine; Electrophoresis, Polyacrylamide Gel; Female; Kidney; Mice; Mice, Inbred BALB C; Ornithine; Ornithine Decarboxylase | 1984 |
Induction of brain ornithine decarboxylase during recovery from metabolic, mechanical, thermal, or chemical injury.
Topics: Animals; Brain; Brain Injuries; Dactinomycin; Eflornithine; Hot Temperature; Hypoxia; Injections, Intraventricular; Male; Mannitol; Ornithine; Ornithine Decarboxylase; Rats; Rats, Inbred Strains; Stress, Mechanical | 1984 |
Phase I trial and pharmacokinetic studies of alpha-difluoromethylornithine--an inhibitor of polyamine biosynthesis.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Eflornithine; Humans; Kinetics; Middle Aged; Neoplasms; Ornithine; Polyamines | 1984 |
Role of polyamines in differentiation of 3T3-L1 fibroblasts into adipocytes.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Eflornithine; Fibroblasts; Mice; Ornithine; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
Some effects of inhibitors of polyamine synthesis on experimental prostatic cancer.
Topics: Adenine; Adenocarcinoma; Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Guanidines; Male; Mice; Mice, Nude; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prostatic Neoplasms; Rats; Vidarabine | 1984 |
Effects of polyamine depletion on proliferation and differentiation of murine erythroleukemia cells.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Diazepam; Dimethyl Sulfoxide; Eflornithine; Kinetics; Leukemia, Experimental; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
Autoradiographic localization of ornithine decarboxylase in mouse kidney by use of radiolabeled alpha-difluoromethylornithine.
Topics: Animals; Autoradiography; Carbon Radioisotopes; Eflornithine; Kidney; Kidney Tubules, Distal; Kidney Tubules, Proximal; Kinetics; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Tritium | 1984 |
Role of antibody in the elimination of trypanosomes after DL-alpha-difluoromethylornithine chemotherapy.
Topics: Animals; Antibodies; Antibody Formation; Antigens, Surface; Cyclophosphamide; Eflornithine; Immunosuppression Therapy; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Ornithine; Recurrence; Trypanocidal Agents; Trypanosoma; Trypanosomiasis, African | 1983 |
Neonatal methyl mercury exposure: biochemical mechanisms in the developing kidney.
Topics: Animals; Animals, Newborn; Eflornithine; Hypertrophy; Kidney; Methylmercury Compounds; Organ Size; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Sympathectomy, Chemical | 1983 |
Potentiation of antitumor activity of alpha-difluoromethyl ornithine by the immunomodulating peptide tuftsin.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Synergism; Eflornithine; Immunity, Cellular; Macrophages; Melanoma; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Ornithine; Polyamines; Tuftsin | 1983 |
Decreased protein-synthetic activity is an early consequence of spermidine depletion in rat hepatoma tissue-culture cells.
Topics: Animals; Cell Division; Cells, Cultured; Centrifugation, Density Gradient; Cycloheximide; Eflornithine; Liver Neoplasms, Experimental; Macromolecular Substances; Neoplasm Proteins; Ornithine; Polyribosomes; Putrescine; Rats; Spermidine; Spermine | 1984 |
Transfer of intestine-derived diamines into tumour cells during treatment of Ehrlich-ascites--carcinoma-bearing mice with polyamine anti-metabolites.
Topics: Animals; Cadaverine; Carcinoma, Ehrlich Tumor; Diamines; Eflornithine; Guanidines; Mice; Mitoguazone; Ornithine; Putrescine | 1984 |
Factors which may be significant regarding regulation of the clofibrate-dependent induction of hepatic peroxisomal beta-oxidation and hepatomegaly.
Topics: Adenosylmethionine Decarboxylase; Adrenalectomy; Animals; Clofibrate; Eflornithine; Hepatomegaly; Hypophysectomy; Liver; Male; Microbodies; Ornithine; Ornithine Decarboxylase; Oxidation-Reduction; Polyamines; Rats; Rats, Inbred Strains; Thyroidectomy | 1984 |
Involvement of spermidine in proliferation and differentiation of human promyelocytic leukemia cells.
Topics: Acetamides; Antineoplastic Agents; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Humans; Leukemia, Myeloid, Acute; Ornithine; Putrescine; Spermidine; Spermine | 1984 |
Time dependence of the potentiation of 1,3-bis(2-chloroethyl)-1-nitrosourea cytotoxicity caused by alpha-difluoromethylornithine-induced polyamine depletion in 9L rat brain tumor cells.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Line; Drug Synergism; Eflornithine; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Spermidine | 1984 |
Synergistic antiproliferative activity of leukocyte interferon in combination with alpha-difluoromethylornithine against human cells in culture.
Topics: Antineoplastic Agents; Burkitt Lymphoma; Cell Line; Cell Survival; Drug Synergism; Eflornithine; Humans; Interferon Type I; Kinetics; Ornithine | 1984 |
Potentiation of antitumor and antimetastatic activities of alpha-difluoromethylornithine by interferon inducers.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Drug Synergism; Eflornithine; Fluorenes; Lung Neoplasms; Melanoma; Mice; Mice, Inbred C57BL; Ornithine; Poly I-C; Polyamines; Tilorone | 1984 |
Possible factors in the potentiation of 1-(2-chloroethyl)-3-trans-4-methylcyclohexyl-1-nitrosourea cytotoxicity by alpha-difluoromethylornithine in 9L rat brain tumor cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cell Line; Cell Survival; Drug Synergism; Eflornithine; Ornithine; Polyamines; Rats; Semustine; Time Factors; Tumor Stem Cell Assay | 1984 |
[Combined therapy with polyamine biosynthesis inhibitors and mitomycin C].
Topics: Animals; DNA Replication; DNA, Neoplasm; Drug Therapy, Combination; Eflornithine; Guanidines; Humans; Mice; Mice, Nude; Mitoguazone; Mitomycin; Mitomycins; Neoplasm Transplantation; Ornithine; Stomach Neoplasms | 1984 |
Mode of interaction of ornithine decarboxylase with antizyme and alpha-difluoromethylornithine.
Topics: Animals; Eflornithine; Enzyme Inhibitors; Female; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Proteins; Putrescine; Rats | 1984 |
Antigrowth effect of polyamine biosynthesis inhibitors on the Dunning R 3327-G prostatic tumor.
Topics: Adenocarcinoma; Animals; Body Weight; Cell Division; Drug Therapy, Combination; Eflornithine; Guanidines; Male; Mitoguazone; Ornithine; Polyamines; Prostatic Neoplasms; Rats; Rats, Inbred Strains | 1984 |
Polyamines in the response to intestinal obstruction.
Topics: Animals; Colon; Eflornithine; Gastric Mucosa; Hyperplasia; Ileum; Intestinal Obstruction; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Inbred Strains | 1984 |
Differential effects of 2-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the testosterone-induced growth of ventral prostate and seminal vesicles of castrated rats.
Topics: Animals; Castration; Eflornithine; Guanidines; Male; Mitoguazone; Ornithine; Polyamines; Prostate; Rats; Rats, Inbred Strains; Seminal Vesicles; Testosterone | 1984 |
Effects of alpha-difluoromethylornithine and recombinant interferon-alpha 2 on the growth of a human renal cell adenocarcinoma xenograft in nude mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cell Division; Cell Line; Clone Cells; Drug Synergism; Eflornithine; Humans; Interferon Type I; Kidney Neoplasms; Killer Cells, Natural; Male; Mice; Mice, Nude; Neoplasm Transplantation; Ornithine; Polyamines; Transplantation, Heterologous | 1984 |
Ornithine decarboxylase activity in the rat and human colon.
Topics: Animals; Colon; Deoxycholic Acid; Dietary Fats; Eflornithine; Humans; Intestinal Mucosa; Kinetics; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred Strains | 1984 |
Enhancement of 1,3-bis(2-chloroethyl)-1-nitrosourea-induced cytotoxicity and DNA damage by alpha-difluoromethylornithine in L1210 leukemia cells.
Topics: Animals; Carmustine; Cell Survival; DNA, Neoplasm; Drug Synergism; Eflornithine; Kinetics; Leukemia L1210; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Spermine | 1984 |
The role of polyamines in somatomedin-stimulated differentiation of L6 myoblasts.
Topics: Animals; Cell Count; Cell Differentiation; Cell Line; Creatine Kinase; Eflornithine; Insulin-Like Growth Factor II; Muscles; Ornithine; Ornithine Decarboxylase; Peptides; Polyamines; Rats; Somatomedins; Time Factors | 1984 |
Polyamines as mediators of estrogen action on the growth of experimental breast cancer in rats.
Topics: Animals; Cell Aggregation; Eflornithine; Estradiol; Female; Mammary Neoplasms, Experimental; Methylnitrosourea; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1984 |
The mechanism of hepatoprotection by epsilon aminocaproic acid and putrescine.
Topics: Aminocaproates; Aminocaproic Acid; Animals; Chemical and Drug Induced Liver Injury; Eflornithine; Galactosamine; Liver Diseases; Necrosis; Ornithine; Ornithine Decarboxylase Inhibitors; Protease Inhibitors; Putrescine; Rats; Rats, Inbred Strains; Urokinase-Type Plasminogen Activator | 1984 |
Different efflux rates may determine the cellular accumulation of various bis(guanylhydrazones).
Topics: Animals; Cells, Cultured; Eflornithine; Guanidines; Leukemia L1210; Mice; Mitoguazone; Ornithine; Spermidine; Time Factors | 1984 |
Enhancement of the rate of spontaneous mutation to 6-thioguanine resistance in mammalian cells by polyamine depletion.
Topics: Animals; Basophils; Drug Resistance; Eflornithine; Leukemia, Experimental; Methylnitronitrosoguanidine; Mutation; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Thioguanine | 1984 |
Polyamine requirements for induction of HL-60 promyelocyte differentiation by leukocyte-conditioned medium and phorbol ester.
Topics: Antibodies, Monoclonal; Cell Differentiation; Cell Line; Culture Media; Eflornithine; Humans; Kinetics; Leukemia, Myeloid, Acute; Leukocytes; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Spermidine; Tetradecanoylphorbol Acetate | 1984 |
Effects of alpha-difluoromethylornithine and methylglyoxal bis(guanylhydrazone) on the growth of experimental renal adenocarcinoma in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Cell Division; Drug Synergism; Eflornithine; Guanidines; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Mitoguazone; Neoplasm Metastasis; Ornithine; Tissue Distribution | 1984 |
Decreased cell kill of vincristine and methotrexate against 9L rat brain tumor cells in vitro caused by alpha-difluoromethylornithine-induced polyamine depletion.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Division; Cell Line; Cell Survival; Eflornithine; Kinetics; Methotrexate; Mitotic Index; Ornithine; Polyamines; Rats; Vincristine | 1984 |
Induction of major chromosome aberrations in Chinese hamster ovary cells by alpha-difluoromethylornithine.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Chromosome Aberrations; Cricetinae; Cricetulus; Eflornithine; Female; Karyotyping; Kinetics; Ornithine; Ovary | 1984 |
Polyamines in Entamoeba invadens.
Topics: Animals; Cell Division; Eflornithine; Entamoeba; Ornithine; Polyamines | 1984 |
Inhibition by DL-alpha-difluoromethylornithine of the pokeweed mitogen-induced immunoglobulin production in cultured human lymphocytes.
Topics: Cells, Cultured; Eflornithine; Humans; Immunoglobulin G; Immunoglobulin M; Lymphocytes; Ornithine; Ornithine Decarboxylase Inhibitors; Pokeweed Mitogens; Radioimmunoassay | 1984 |
Inhibition of intestinal epithelial DNA synthesis and adaptive hyperplasia after jejunectomy in the rat by suppression of polyamine biosynthesis.
Topics: Animals; DNA Replication; Eflornithine; Epithelium; Female; Hyperplasia; Intestinal Mucosa; Intestine, Small; Jejunum; Ornithine; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred Strains | 1984 |
Polyamine biosynthetic enzymes as targets in cancer chemotherapy.
Topics: Adenine Nucleotides; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Cell Line; Cell Transformation, Neoplastic; DNA; Eflornithine; Enzyme Inhibitors; Methionine; Mice; Ornithine; Putrescine; Spermidine; Spermine; Teratoma | 1984 |
Glyoxal bis(guanylhydrazone) as an inhibitor of polyamine biosynthesis in tumour cells.
Topics: Adenosylmethionine Decarboxylase; Amine Oxidase (Copper-Containing); Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; DNA, Neoplasm; Eflornithine; Female; Guanidines; Leukemia L1210; Mice; Mitoguazone; Neoplasm Proteins; Ornithine; Polyamines | 1984 |
Dissociated regulation of growth and ornithine decarboxylase activity by estrogen in the rat uterus.
Topics: Aging; Animals; Castration; Eflornithine; Estradiol; Female; Organ Size; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Inbred Strains; Uterus | 1984 |
Role of polyamine synthesis in the stimulation of hexose transport by epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate in cultured mouse fibroblasts.
Topics: Animals; Cells, Cultured; Deoxyglucose; Eflornithine; Epidermal Growth Factor; Fibroblasts; Hexoses; Mice; Ornithine; Polyamines; Putrescine; Tetradecanoylphorbol Acetate | 1984 |
Polyamines in brain and heart of the neonatal rat: effects of inhibitors of ornithine decarboxylase and spermidine synthase.
Topics: Animals; Animals, Newborn; Brain; Cyclohexylamines; Dose-Response Relationship, Drug; Eflornithine; Female; Heart; Male; Myocardium; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermidine Synthase; Spermine; Transferases | 1984 |
Potential uses of polyamine biosynthesis inhibitors in tumor therapy.
Topics: Animals; Antineoplastic Agents; Cell Cycle; DNA Repair; Drug Therapy, Combination; Eflornithine; Humans; Mitoguazone; Neoplasms; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Sister Chromatid Exchange | 1984 |
Polyamine levels and the activity of their biosynthetic enzymes in human erythrocytes infected with the malarial parasite, Plasmodium falciparum.
Topics: Adenosylmethionine Decarboxylase; Blood Proteins; Carboxy-Lyases; Cells, Cultured; Eflornithine; Erythrocytes; Humans; Malaria; Nucleic Acids; Ornithine; Ornithine Decarboxylase; Plasmodium falciparum; Polyamines | 1984 |
Antitumor properties of (2R,5R)-6-heptyne-2,5-diamine, a new potent enzyme-activated irreversible inhibitor of ornithine decarboxylase, in rodents.
Topics: Alkynes; Animals; Antineoplastic Agents; Diamines; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Eflornithine; Female; Leukemia L1210; Leukemia P388; Liver Neoplasms, Experimental; Lung Neoplasms; Mammary Neoplasms, Experimental; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred BUF | 1984 |
Inhibition of growth of human or hamster pancreatic cancer cell lines by alpha-difluoromethylornithine alone and combined with cis-diamminedichloroplatinum(II).
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Cell Survival; Cisplatin; Cricetinae; Drug Evaluation, Preclinical; Drug Interactions; Eflornithine; Humans; Kinetics; Ornithine; Pancreatic Neoplasms; Putrescine | 1984 |
Physiological effects in bovine lymphocytes of inhibiting polyamine synthesis with ethylglyoxal bis(guanylhydrazone).
Topics: Animals; Aphidicolin; Cattle; Cycloheximide; Diterpenes; DNA Replication; Eflornithine; Guanidines; Kinetics; Lymphocytes; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protein Biosynthesis; Proteins; Spermidine | 1984 |
CNS toxicity and CSF pharmacokinetics of intraventricular DFMO and MGBG in beagle dogs.
Topics: Animals; Antimetabolites, Antineoplastic; Cerebral Ventricles; Dogs; Eflornithine; Guanidines; Injections, Intraventricular; Male; Metabolic Clearance Rate; Mitoguazone; Ornithine | 1984 |
Effects of cycloheximide, alpha-amanitin, and alpha-difluoromethylornithine on thyrotropin-induced increases in the micrococcal nuclease sensitivity of thyroid nuclear chromatin.
Topics: Amanitins; Animals; Cattle; Cell Nucleus; Chromatin; Cycloheximide; DNA; Eflornithine; In Vitro Techniques; Micrococcal Nuclease; Ornithine; Ornithine Decarboxylase Inhibitors; Thyroid Gland; Thyrotropin | 1984 |
A human neuroblastoma cell line with an altered ornithine decarboxylase.
Topics: Cell Line; Eflornithine; Humans; Karyotyping; Kinetics; Neuroblastoma; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Protein Binding; Tritium | 1984 |
Polyamines and the development of monocrotaline-induced pulmonary hypertension.
Topics: Adenosylmethionine Decarboxylase; Animals; Blood Pressure; Eflornithine; Heart Ventricles; Hypertension, Pulmonary; Hypertrophy; Kinetics; Lung; Male; Monocrotaline; Ornithine; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Polyamines; Putrescine; Pyrrolizidine Alkaloids; Rats; Rats, Inbred Strains; Senecio; Spermidine; Spermine | 1984 |
Polyamines and intestinal growth: absolute requirement for ODC activity in adaptation during lactation.
Topics: Adaptation, Physiological; Adenosylmethionine Decarboxylase; Animals; Cell Division; Eflornithine; Female; Intestinal Mucosa; Intestine, Small; Lactation; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Rats | 1984 |
New therapeutic approaches for brain tumors.
Topics: Brachytherapy; Brain Neoplasms; Bromodeoxyuridine; Eflornithine; Humans; Hyperthermia, Induced; Iodine Radioisotopes; Mitoguazone; Ornithine; Polyamines | 1984 |
Effect of D,L-alpha-difluoromethylornithine on murine mammary carcinogenesis.
Topics: Animals; Antineoplastic Agents; Eflornithine; Female; Mammary Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Inbred Strains | 1984 |
Treatment with alpha-difluoromethylornithine plus a spermidine analog leads to spermine depletion and growth inhibition in cultured L1210 leukemia cells.
Topics: Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Eflornithine; Leukemia L1210; Mice; Ornithine; Spermidine; Spermine | 1984 |
Reversal of the growth inhibitory effect of alpha-difluoromethylornithine by putrescine but not by other divalent cations.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cell Division; Diamines; Eflornithine; Kinetics; Magnesium; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Structure-Activity Relationship | 1984 |
New drug combination for experimental late-stage African trypanosomiasis: DL-alpha-difluoromethylornithine (DFMO) with suramin.
Topics: Animals; Disease Models, Animal; Drug Therapy, Combination; Eflornithine; Humans; Injections, Intravenous; Mice; Ornithine; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African | 1984 |
The role of polyamine depletion and accumulation of decarboxylated S-adenosylmethionine in the inhibition of growth of SV-3T3 cells treated with alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cells, Cultured; Diamines; Eflornithine; Fibroblasts; Mice; Mice, Inbred Strains; Ornithine; Polyamines; S-Adenosylmethionine; Spermidine | 1984 |
Inhibition of growth of Mycoplasma dispar by DL-alpha-difluoromethyllsine, a selective irreversible inhibitor of lysine decarboxylase, and reversal by cadaverine (1,5-diaminopentane).
Topics: Arginine; Cadaverine; Carboxy-Lyases; Cell Division; Diamines; Eflornithine; Lysine; Mycoplasma; Ornithine | 1984 |
Polyamines and pancreatic growth induced by caerulein.
Topics: Animals; Ceruletide; DNA; Eflornithine; Male; Organ Size; Ornithine; Pancreas; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1984 |
Morphological changes in Trypanosoma brucei rhodesiense following inhibition of polyamine biosynthesis in vivo.
Topics: Animals; Eflornithine; Erythrocytes; Mice; Mice, Inbred Strains; Microscopy, Electron; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Trypanosoma; Trypanosomiasis, African | 1984 |
Pneumocystis carinii pneumonia treated with alpha-difluoromethylornithine. A prospective study among patients with the acquired immunodeficiency syndrome.
Topics: Acquired Immunodeficiency Syndrome; Adult; Eflornithine; Humans; Male; Middle Aged; Ornithine; Pneumonia, Pneumocystis; Prospective Studies; Trypanocidal Agents | 1984 |
Localization of ornithine decarboxylase in mutant CHO cells that overproduce the enzyme. Differences between the intracellular distribution of monospecific ornithine decarboxylase antibodies and radiolabeled alpha-difluoromethylornithine.
Topics: Animals; Antibodies; Antigen-Antibody Complex; Autoradiography; Cell Division; Cell Line; Cricetinae; Cricetulus; Eflornithine; Female; Fluorescent Antibody Technique; Microscopy, Electron; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ovary; Tritium | 1984 |
Successful treatment of lethal protozoal infections with the ornithine decarboxylase inhibitor, alpha-difluoromethylornithine.
Topics: Acquired Immunodeficiency Syndrome; Adolescent; Adult; Child; Eflornithine; Female; Humans; Male; Middle Aged; Ornithine; Ornithine Decarboxylase Inhibitors; Pneumonia, Pneumocystis; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosomiasis, African | 1984 |
Role of ornithine decarboxylase in cardiac growth and hypertrophy.
Topics: Animals; Carboxy-Lyases; Cardiomegaly; Eflornithine; Heart; Isoproterenol; Male; Myocardium; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Triiodothyronine | 1980 |
Effect of alpha-difluoromethylornithine on cardiac polyamine content and hypertrophy.
Topics: Animals; Cardiomegaly; Eflornithine; Heart; Male; Myocardium; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Inbred Strains; Thyroxine | 1981 |
alpha-(Fluoromethyl)dehydroornithine and alpha-(fluoromethyl)dehydroputrescine analogues as irreversible inhibitors of ornithine decarboxylase.
Topics: Animals; Eflornithine; Indicators and Reagents; Isomerism; Kinetics; Liver; Magnetic Resonance Spectroscopy; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Structure-Activity Relationship | 1983 |
L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Embryo, Mammalian; Female; Gestational Age; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Rabbits; Rats; Uterus | 1980 |
Antitumor effects of vitamin A and inhibitors of ornithine decarboxylase in cultured neuroblastoma and glioma cells.
Topics: Animals; Antineoplastic Agents; Carboxy-Lyases; Cell Division; Cell Line; Drug Evaluation, Preclinical; Eflornithine; Glioma; Mice; Neuroblastoma; Ornithine; Ornithine Decarboxylase Inhibitors; Rats; Retinaldehyde; Tretinoin; Vitamin A | 1980 |
Irreversible inhibition of the early increase in ornithine decarboxylase activity following growth stimulation is required to block Ehrlich ascites tumor cell proliferation in culture.
Topics: Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Cell Division; Eflornithine; Kinetics; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1980 |
Polyamine depletion induces enhanced synthesis and accumulation of cadaverine in cultured Ehrlich ascites carcinoma cells.
Topics: Animals; Cadaverine; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Cells, Cultured; Diamines; Eflornithine; Female; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine | 1980 |
Inhibition of murine embryonic development by alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Embryo, Mammalian; Female; Male; Mice; Nucleic Acids; Organ Size; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Proteins; Uterus | 1980 |
Inhibition of polyamine biosynthesis by alpha-difluoromethyl ornithine potentiates the cytotoxic effects of arabinosyl cytosine in HeLa cells.
Topics: Carboxy-Lyases; Cell Cycle; Cell Division; Cell Survival; Cytarabine; Drug Synergism; Eflornithine; HeLa Cells; Humans; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1980 |
Polyamine metabolism: a potential therapeutic target in trypanosomes.
Topics: Animals; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1980 |
Depletion of intracellular polyamine content does not alter the survival of 9L rat brain tumour cells after X-irradiation.
Topics: Animals; Brain Neoplasms; Cell Line; Cell Survival; Cells, Cultured; DNA; DNA, Neoplasm; Eflornithine; Guanidines; Mitoguazone; Ornithine; Polyamines; Putrescine; Radiation Tolerance; Rats; Spermidine; Spermine; X-Rays | 1980 |
Increased ornithine decarboxylase activity during meiotic maturation in Xenopus laevis oocytes.
Topics: Animals; Carboxy-Lyases; Cholera Toxin; Eflornithine; Female; In Vitro Techniques; Meiosis; Oocytes; Ornithine; Ornithine Decarboxylase; Ovum; Progesterone; Xenopus laevis | 1980 |
Histochemical localization of ornithine decarboxylase with a labelled suicidal enzyme inhibitor.
Topics: Animals; Carboxy-Lyases; Cerebellum; Eflornithine; Histocytochemistry; In Vitro Techniques; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rhodamines | 1980 |
Effect of alpha-difluoromethyl ornithine on the transplantable rat hepatoma 5123, 1-1.
Topics: Animals; Antineoplastic Agents; Body Weight; Eflornithine; Liver Neoplasms, Experimental; Neoplasm Transplantation; Ornithine; Ornithine Decarboxylase Inhibitors; Rats; Transplantation, Homologous | 1980 |
Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.
Topics: Animals; Brain Neoplasms; Cell Division; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Interphase; Ornithine; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1981 |
Inhibition of cell proliferation by DL-alpha-difluoromethylornithine, a catalytic irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Catalysis; Cell Division; Cells, Cultured; Eflornithine; Ornithine; Ornithine Decarboxylase Inhibitors | 1980 |
DL-alpha Difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, blocks chick embryo development at gastrulation.
Topics: Animals; Carboxy-Lyases; Chick Embryo; Eflornithine; Gastrula; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1980 |
Regulation of S-adenosylmethionine decarboxylase by polyamines in Ehrlich ascites-carcinoma cells grown in culture.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Cells, Cultured; Diamines; Eflornithine; Enzyme Induction; Ornithine; Polyamines; Propanolamines | 1980 |
Ovarian function in the rat following irreversible inhibition of L-ornithine decarboxylase.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Eflornithine; Estrus; Female; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Ovary; Ovulation; Pregnancy; Putrescine; Rats; Spermidine; Spermine | 1980 |
[Polyamines in psoriasis].
Topics: Anthralin; Carboxy-Lyases; Chemical Phenomena; Chemistry; Double-Blind Method; Eflornithine; Humans; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Psoriasis; PUVA Therapy | 1980 |
alpha-Difluoromethylornithine (alpha DFMO) and phenoxybenzamine hydrochloride in the treatment of chronic non-suppurative prostatitis.
Topics: Adult; Blood Cell Count; Chronic Disease; Drug Therapy, Combination; Eflornithine; Humans; Male; Middle Aged; Ornithine; Phenoxybenzamine; Prostatitis | 1981 |
Intracellular putrescine and spermidine deprivation induces increased uptake of the natural polyamines and methylglyoxal bis(guanylhydrazone).
Topics: Adenosylmethionine Decarboxylase; Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Mitoguazone; Ornithine; Ornithine Decarboxylase; Putrescine; Spermidine | 1980 |
Polyamine deprivation-induced enhanced uptake of methylglyoxal bis(guanylhydrazone) by tumor cells.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cell Line; Eflornithine; Female; Guanidines; Humans; Iodoacetates; Iodoacetic Acid; Leukemia, Lymphoid; Mice; Mitoguazone; Ornithine; Putrescine; Spermine | 1981 |
Sensitization of 9L rat brain gliosarcoma cells to 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
Topics: Animals; Brain Neoplasms; Carmustine; Cell Cycle; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Eflornithine; Glioma; Kinetics; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats | 1981 |
Kinetics of alpha-difluoromethylornithine: an irreversible inhibitor of ornithine decarboxylase.
Topics: Administration, Oral; Adult; Eflornithine; Humans; Infusions, Parenteral; Kinetics; Male; Models, Biological; Ornithine; Ornithine Decarboxylase Inhibitors | 1981 |
Assay of alpha-difluoromethylornithine in body fluids and tissues by automatic amino-acid analysis.
Topics: Amino Acids; Animals; Autoanalysis; Dogs; Eflornithine; Half-Life; Haplorhini; Humans; Ornithine; Rabbits; Rats | 1981 |
Cytochemical localization of ornithine decarboxylase with rhodamine or biotin-labeled alpha-difluoromethylornithine. An example for the use of labeled irreversible enzyme inhibitors as cytochemical markers.
Topics: Affinity Labels; Animals; Biotin; Carboxy-Lyases; Cerebellum; Eflornithine; Female; Fluorescent Dyes; Histocytochemistry; Liver; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rhodamines; Xanthenes | 1981 |
UV-induced changes in urinary polyamine excretion in the mouse.
Topics: Acetylation; Animals; Eflornithine; Female; Mice; Ornithine; Polyamines; Skin; Time Factors; Ultraviolet Rays | 1981 |
Comparative effects of topical anthralin and difluoromethylornithine (alpha DFMO) on epidermal polyamine concentration in psoriasis.
Topics: Anthracenes; Anthralin; Eflornithine; Humans; Ornithine; Polyamines; Psoriasis; Skin | 1981 |
Selective killing of transformed cells in combination with inhibitors of polyamine biosynthesis and S-phase specific drugs.
Topics: Cell Division; Cell Transformation, Neoplastic; Cytarabine; Drug Synergism; Eflornithine; HeLa Cells; Humans; Interphase; Ornithine; Polyamines; Spermidine; Spermine | 1981 |
A mutant of Chinese hamster ovary cells resistant to alpha-methyl- and alpha-difluoromethylornithine.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Drug Resistance; Eflornithine; Female; Kinetics; Mutation; Ornithine; Ornithine Decarboxylase; Ovary; Time Factors | 1981 |
Binding of radioactive alpha-difluoromethylornithine to rat liver ornithine decarboxylase.
Topics: Animals; Carboxy-Lyases; Eflornithine; In Vitro Techniques; Liver; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rats, Inbred Strains | 1981 |
Several inhibitors of ornithine and adenosylmethionine decarboxylases may also have antiproliferative effects unrelated to polyamine depletion.
Topics: Adenosylmethionine Decarboxylase; Carboxy-Lyases; Cell Division; Cells, Cultured; Diamines; DNA; Eflornithine; Humans; Lymphocyte Activation; Lymphocytes; Ornithine; Ornithine Decarboxylase Inhibitors; Phytohemagglutinins; Polyamines | 1981 |
Aminoguanidine reversal of the inhibitory effects of ornithine analogs on the in vitro clonogenic survival of the R3327AT prostate-derived tumor.
Topics: Amine Oxidase (Copper-Containing); Animals; Carboxy-Lyases; Cell Line; Eflornithine; Guanidines; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Prostatic Neoplasms; Putrescine; Rats | 1981 |
Alpha-difluoromethylornithine as a postcoitally effective antifertility agent in female rats.
Topics: Animals; Contraceptives, Postcoital; Contraceptives, Postcoital, Synthetic; Eflornithine; Embryo Implantation; Embryo, Mammalian; Female; Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); Litter Size; Ornithine; Ornithine Decarboxylase; Pregnancy; Rabbits; Uterus | 1981 |
Death of tumor cells in response to the use of a system of stimulated polyamine uptake from the transport of methylglyoxal bis(guanylhydrazone).
Topics: Animals; Biological Transport; Carcinoma, Ehrlich Tumor; Cell Survival; Cells, Cultured; Eflornithine; Guanidines; Mitoguazone; Ornithine; Polyamines | 1981 |
Polyamines are needed for the differentiation of 3T3-L1 fibroblasts into adipose cells.
Topics: Adipose Tissue; Animals; Cell Differentiation; Cells, Cultured; Eflornithine; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1981 |
Potentiation of the antitumor therapeutic effects of 1,3-bis(2-chloroethyl)-1-nitrosourea by alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor.
Topics: Animals; Brain Neoplasms; Carmustine; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Eflornithine; Male; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Ornithine; Rats; Rats, Inbred F344; Time Factors | 1981 |
Effects of alpha-difluoromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia in mice, EMT6 solid tumors in mice, and solid tumors induced by injection of hepatoma tissue culture cells in rats.
Topics: Animals; Doxorubicin; Drug Therapy, Combination; Eflornithine; Female; Leukemia L1210; Liver Neoplasms, Experimental; Male; Mice; Neoplasms, Experimental; Ornithine; Rats; Vinblastine; Vindesine | 1981 |
Synergistic action of two polyamine antimetabolites leads to a rapid therapeutic response in childhood leukemia.
Topics: Antineoplastic Agents; Child; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Eflornithine; Female; Guanidines; Humans; Infant; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Male; Mitoguazone; Ornithine | 1981 |
Decarboxylation of ornithine and lysine by ornithine decarboxylase from kidneys of testosterone treated mice.
Topics: Animals; Cadaverine; Carboxy-Lyases; Eflornithine; Kidney; Lysine; Male; Mice; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Testosterone | 1981 |
Indirect evidence for a strict negative control of S-adenosyl-L-methionine decarboxylase by spermidine in rat hepatoma cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cell Division; Cell Line; Eflornithine; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Spermidine | 1981 |
Response of enzymes involved in the metabolism of polyamines to phytohaemagglutinin-induced activation of human lymphocytes.
Topics: Adenosylmethionine Decarboxylase; Cells, Cultured; Eflornithine; Enzyme Induction; Humans; Lymphocyte Activation; Lymphocytes; Ornithine; Ornithine Decarboxylase; Phytohemagglutinins; Polyamines | 1981 |
Antagonism by polyamines of the curative effects of alpha-difluoromethylornithine in Trypanosoma brucei brucei infections.
Topics: Animals; Eflornithine; Female; Male; Mice; Ornithine; Polyamines; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 1981 |
Specificity of mammalian spermidine synthase and spermine synthase.
Topics: Animals; Cell Line; Diamines; Eflornithine; Fibroblasts; Kinetics; Mice; Ornithine; Polyamines; Rats; Spermidine Synthase; Spermine Synthase; Substrate Specificity; Transferases | 1981 |
Difluoromethylornithine irreversibly inactivates ornithine decarboxylase of Pseudomonas aeruginosa, but does not inhibit the enzymes of Escherichia coli.
Topics: Carboxy-Lyases; Eflornithine; Escherichia coli; Kinetics; Klebsiella pneumoniae; Ornithine; Ornithine Decarboxylase Inhibitors; Pseudomonas aeruginosa | 1981 |
Dissociation between ornithine decarboxylase activity and aryl hydrocarbon hydroxylase induction in cell cultures treated with benz[a]anthracene and inhibitors of ornithine decarboxylase.
Topics: Aryl Hydrocarbon Hydroxylases; Benz(a)Anthracenes; Carboxy-Lyases; Cells, Cultured; Eflornithine; Enzyme Induction; HeLa Cells; Humans; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Propanolamines | 1982 |
Effect of alpha-difluoromethylornithine on polyamine and DNA synthesis in regenerating rat liver: reversal of inhibition of DNA synthesis by putrescine.
Topics: Animals; DNA; Eflornithine; Liver; Liver Regeneration; Male; Ornithine; Polyamines; Putrescine; Rats | 1982 |
Decreased cytotoxicity of cis-diamminedichloroplatinum(II) by alpha-difluoromethylornithine depletion of polyamines in 9L rat brain tumor cells in vitro.
Topics: Animals; Brain Neoplasms; Carboxy-Lyases; Cisplatin; DNA; Eflornithine; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats | 1982 |
Reversed-phase ion-pair liquid chromatographic procedure for the simultaneous analysis of S-adenosylmethionine, its metabolites and the natural polyamines.
Topics: Animals; Cells, Cultured; Chromatography, Liquid; Eflornithine; Liver; Liver Neoplasms, Experimental; Male; Ornithine; Polyamines; Prostate; Rats; Rats, Inbred Strains; S-Adenosylmethionine; Time Factors | 1982 |
Formation and interconversion of putrescine and spermidine in mammalian cells.
Topics: Acetyltransferases; Adenosylmethionine Decarboxylase; Animals; Cell Line; Eflornithine; Enzyme Activation; Enzyme Repression; Liver; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine | 1980 |
Effects of inhibitors of ornithine and S-adenosylmethionine decarboxylases on L6 myoblast proliferation.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; Cells, Cultured; Eflornithine; Mitoguazone; Muscles; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; Spermidine; Spermine | 1982 |
Effect of epidermal polyamine depletion on the accumulation of methylglyoxal bis(guanylhydrazone) in mouse skin.
Topics: Animals; Eflornithine; Female; Guanidines; Mice; Mitoguazone; Ornithine; Polyamines; Putrescine; Skin; Skin Physiological Phenomena; Spermidine | 1982 |
Metabolism of acetyl derivatives of polyamines in cultured polyamine-deficient rat hepatoma cells.
Topics: Acetylation; Acetyltransferases; Animals; Cell Division; Cell Line; Eflornithine; Liver Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Rats | 1981 |
Role of polyamines in HeLa cell proliferation.
Topics: Cell Division; DNA; Eflornithine; HeLa Cells; Humans; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines | 1981 |
Role of the polyamines in germ cell differentiation and in early embryonic development.
Topics: Animals; Cell Differentiation; Chick Embryo; Eflornithine; Embryo, Nonmammalian; Oogenesis; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Polychaeta; Sea Urchins | 1981 |
An approach to the use of polyamine inhibitors for cancer therapy.
Topics: Animals; Antimetabolites, Antineoplastic; Brain Neoplasms; Carmustine; Drug Therapy, Combination; Eflornithine; Neoplasms, Experimental; Ornithine; Polyamines; Rats | 1981 |
Some properties of the polyamine deprivation-inducible uptake system for methylglyoxal bis(guanylhydrazone) in tumor cells.
Topics: Animals; Carcinoma, Ehrlich Tumor; Cells, Cultured; Eflornithine; Guanidines; Iodoacetates; Iodoacetic Acid; Mice; Mitoguazone; Neoplasms, Experimental; Ornithine; Ouabain; Polyamines; Putrescine; Spermidine | 1981 |
Accumulation of decarboxylated S-adenosyl-L-methionine in mammalian cells as a consequence of the inhibition of putrescine biosynthesis.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cells, Cultured; Eflornithine; Liver Neoplasms, Experimental; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Prostate; Putrescine; Rats; Rats, Inbred Strains | 1982 |
Polyamines in mycoplasmas and in mycoplasma-infected tumour cells.
Topics: Animals; Carboxy-Lyases; Carcinoma, Ehrlich Tumor; Cattle; Cells, Cultured; Eflornithine; Leukemia L1210; Mycoplasma; Ornithine; Ornithine Decarboxylase; Polyamines; Rats | 1982 |
Effect of androgens on turnover of ornithine decarboxylase in mouse kidney. Studies using labeling of the enzyme by reaction with [14C] alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cycloheximide; Eflornithine; Half-Life; Kidney; Kinetics; Male; Mice; Mice, Inbred BALB C; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Species Specificity; Testosterone | 1982 |
Autoradiographic identification of ornithine decarboxylase in mouse kidney by means of alpha-[5-14C]difluoromethylornithine.
Topics: Animals; Autoradiography; Brain; Carbon Radioisotopes; Carboxy-Lyases; Eflornithine; Kidney; Liver; Mice; Organ Specificity; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Testosterone | 1982 |
Effect of inhibition of polyamine synthesis on the content of decarboxylated S-adenosylmethionine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Cells, Cultured; Eflornithine; Fibroblasts; Liver; Liver Regeneration; Male; Mice; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1982 |
Ornithine decarboxylase protein diversity and activity modulation in HTC cells.
Topics: Animals; Carboxy-Lyases; Cell Division; Cell Line; Eflornithine; Enzyme Induction; Kinetics; Liver Neoplasms, Experimental; Mutation; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats | 1982 |
Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
Topics: Adenosylmethionine Decarboxylase; Animals; Carboxy-Lyases; Drug Antagonism; Eflornithine; Kinetics; Mice; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbols; Polyamines; Putrescine; Skin; Skin Neoplasms; Spermidine; Spermine; Tetradecanoylphorbol Acetate | 1982 |
An essential role for polyamine biosynthesis during human granulopoietic differentiation.
Topics: Bone Marrow; Cell Differentiation; Cells, Cultured; Culture Media; Eflornithine; Granulocytes; Humans; Macrophages; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine | 1982 |
Growth-inhibitory effects of DL-alpha-difluoromethylornithine in the spectrum of human lung carcinoma cells in culture.
Topics: Antineoplastic Agents; Cell Division; Cell Line; Drug Evaluation, Preclinical; Eflornithine; Humans; Kinetics; Lung Neoplasms; Ornithine | 1982 |
Replacement of natural polyamines by cadaverine and its aminopropyl derivatives in Ehrlich ascites carcinoma cells.
Topics: Animals; Cadaverine; Carcinoma, Ehrlich Tumor; Cell Division; Diamines; DNA Replication; Eflornithine; Kinetics; Mice; Ornithine; Protein Biosynthesis; Putrescine; Structure-Activity Relationship; Transcription, Genetic | 1982 |
Dissociation of enhanced ornithine decarboxylase activity and optic nerve regeneration in goldfish.
Topics: Animals; Axons; Carboxy-Lyases; Cyprinidae; Eflornithine; Goldfish; Nerve Regeneration; Optic Nerve; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Retina; Tubulin; Vision, Ocular | 1982 |
Enhancement of ovulation in the rat by DL-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Carboxy-Lyases; Eflornithine; Female; Ornithine; Ornithine Decarboxylase Inhibitors; Ovary; Ovulation; Polyamines; Rats; Rats, Inbred Strains | 1982 |
Ornithine decarboxylase and polyamines in tissues of the neonatal rat: effects of alpha-difluoromethylornithine, a specific, irreversible inhibitor of ornithine decarboxylase.
Topics: Animals; Animals, Newborn; Brain; Carboxy-Lyases; Eflornithine; Female; Heart; Kidney; Myocardium; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Pregnancy; Putrescine; Rats; Rats, Inbred Strains; Spermidine; Spermine | 1982 |
Polyamine depletion influences drug-induced chromosomal damage.
Topics: Animals; Carmustine; Chromosomes; Cisplatin; DNA; Eflornithine; Nucleic Acid Conformation; Ornithine; Polyamines; Putrescine; Rats; Sister Chromatid Exchange; Spermidine; Spermine | 1982 |
Purification of ornithine decarboxylase from kidneys of androgen-treated mice.
Topics: Androgens; Animals; Carboxy-Lyases; Dithiothreitol; Eflornithine; Kidney; Kinetics; Macromolecular Substances; Male; Mice; Ornithine; Ornithine Decarboxylase; Pyridoxal Phosphate | 1982 |
Effects of DL-alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, on the rat mammary tumour induced by 7,12-dimethylbenz[a]anthracene.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Agents; Body Weight; Carboxy-Lyases; Cyclophosphamide; Eflornithine; Female; Mammary Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Inbred Strains | 1982 |
Copenhagen rat prostatic tumor ornithine decarboxylase activity (ODC) and the effect of the ODC inhibitor alpha-difluoromethylornithine.
Topics: Animals; Antineoplastic Agents; Carboxy-Lyases; Cell Line; Eflornithine; Male; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Prostatic Neoplasms; Rats; Rats, Inbred Strains | 1982 |
Synthesis of Semliki-forest virus in polyamine-depleted baby-hamster kidney cells.
Topics: Animals; Cell Line; Cricetinae; DNA-Directed RNA Polymerases; Eflornithine; Kidney; Kinetics; Ornithine; Polyamines; RNA, Viral; Semliki forest virus; Transfection; Virus Replication | 1982 |
Combined topical use of difluoromethyl ornithine and methylglyoxal bis (guanylhydrazone) in UV-irradiated mouse skin.
Topics: Adenosylmethionine Decarboxylase; Animals; Eflornithine; Female; Guanidines; Male; Mice; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Skin; Spermidine; Ultraviolet Rays | 1982 |
Affinity labeling of purified ornithine decarboxylase by alpha-difluoromethylornithine.
Topics: Affinity Labels; Animals; Carboxy-Lyases; Eflornithine; Electrophoresis, Polyacrylamide Gel; Kinetics; Liver; Molecular Weight; Ornithine; Ornithine Decarboxylase Inhibitors; Rats | 1982 |
Relationship of ornithine decarboxylase activity to HCG induced androgen production by rabbit testis.
Topics: Androgens; Animals; Carboxy-Lyases; Chorionic Gonadotropin; Eflornithine; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rabbits; Testis | 1982 |
Independent induction and inhibition of ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in rat epidermis.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Aryl Hydrocarbon Hydroxylases; Carboxy-Lyases; Eflornithine; Enzyme Induction; Epidermis; Male; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polychlorinated Dibenzodioxins; Rats; Rats, Inbred Strains; Skin; Time Factors | 1982 |
Difluoromethylornithine enhancement of putrescine uptake into the prostate: concise communication.
Topics: Animals; Castration; Eflornithine; Male; Ornithine; Ornithine Decarboxylase Inhibitors; Prostate; Putrescine; Rats; Rats, Inbred Strains; Rats, Inbred WF | 1982 |
Ornithine decarboxylase in Trypanosoma brucei brucei: evidence for selective toxicity of difluoromethylornithine.
Topics: Animals; Carboxy-Lyases; Eflornithine; Enzyme Induction; Hydrogen-Ion Concentration; Kinetics; Molecular Weight; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Trypanosoma brucei brucei | 1982 |
Curative effect of alpha-difluoromethylornithine on fatal Trypanosoma congolense infection in mice.
Topics: Animals; Dose-Response Relationship, Drug; Eflornithine; Female; Muridae; Ornithine; Trypanocidal Agents; Trypanosomiasis, African | 1982 |
Uptake of alpha-difluoromethylornithine by mouse fibroblasts.
Topics: Animals; Cells, Cultured; Eflornithine; Fibroblasts; Lysine; Mice; Ornithine | 1982 |
Delayed sensitization to heat by inhibitors of polyamine-biosynthetic enzymes.
Topics: Animals; Carboxy-Lyases; Cell Division; Cell Line; Cell Survival; Cricetinae; Cricetulus; Eflornithine; Female; Guanidines; Hot Temperature; Kinetics; Mitoguazone; Ornithine; Ornithine Decarboxylase Inhibitors; Ovary; Putrescine | 1982 |
Ornithine decarboxylase activity in nucleolus and nucleoplasm demonstrated autoradiographically with tritium-labeled alpha-difluoromethylornithine.
Topics: Animals; Autoradiography; Carboxy-Lyases; Cell Nucleolus; Cell Nucleus; Cytoplasm; Eflornithine; Female; Oocytes; Ornithine; Ornithine Decarboxylase; Ovum; Polychaeta | 1982 |
Evidence for a role of progesterone in the control of uterine ornithine decarboxylase in the pregnant hamster.
Topics: Animals; Antineoplastic Agents; Carboxy-Lyases; Castration; Cricetinae; Dinoprost; Eflornithine; Female; Mesocricetus; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Pregnancy; Pregnancy, Animal; Progesterone; Prostaglandins F; Uterus | 1982 |
Experimental fecal transmission of human cryptosporidia to pigs, and attempted treatment with an ornithine decarboxylase inhibitor.
Topics: Animals; Coccidiosis; Eflornithine; Feces; Humans; Male; Ornithine; Swine; Swine Diseases | 1982 |
alpha-Difluoromethylornithine: a promising lead for preventive chemotherapy for coccidiosis.
Topics: Animals; Cecal Diseases; Chickens; Coccidiosis; Coccidiostats; Eflornithine; Eimeria; Male; Ornithine; Poultry Diseases; Putrescine | 1982 |
Measurement of the number of ornithine decarboxylase molecules in rat and mouse tissues under various physiological conditions by binding of radiolabelled alpha-difluoromethylornithine.
Topics: Animals; Carboxy-Lyases; Cycloheximide; Diamines; Eflornithine; Electrophoresis, Polyacrylamide Gel; In Vitro Techniques; Kidney; Liver; Male; Mice; Mice, Inbred BALB C; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Tissue Distribution | 1982 |
Polyamines: a dual role in the modulation of cellular sensitivity to heat.
Topics: Animals; Cell Membrane; Cell Survival; Cells, Cultured; Eflornithine; Hot Temperature; Ornithine; Polyamines; Time Factors | 1982 |
Restriction of bacterial growth by inhibition of polyamine biosynthesis by using monofluoromethylornithine, difluoromethylarginine and dicyclohexylammonium sulphate.
Topics: Arginine; Cyclohexylamines; Depression, Chemical; Eflornithine; Escherichia coli; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Pseudomonas aeruginosa; Quaternary Ammonium Compounds | 1982 |
An essential role for polyamines in tumor metastases.
Topics: Animals; Antineoplastic Agents; Cell Division; Eflornithine; Lung Neoplasms; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Ornithine; Polyamines | 1982 |
Polyamine cytochemistry. Use of a novel o-phtalaldehyde method for visualizing spermidine and spermine. Comparisons to the formaldehyde-fluorescamine method.
Topics: Aldehydes; Animals; Cats; Eflornithine; Fluorescamine; Formaldehyde; Histocytochemistry; Hydrogen-Ion Concentration; Methods; o-Phthalaldehyde; Ornithine; Polyamines; Rats; Spermidine; Spermine; Spiro Compounds | 1982 |
Inhibitory action of alpha-difluoromethylornithine on rodent malaria (Plasmodium berghei).
Topics: Animals; Blood; Eflornithine; Erythrocytes; Malaria; Mice; Ornithine; Plasmodium berghei | 1982 |
[Antitumor effects of polyamine synthesis inhibitors based on major premise of treatment for human malignant tumor].
Topics: Animals; Cell Division; Drug Synergism; Drug Therapy, Combination; Eflornithine; Gastrointestinal Neoplasms; Guanidines; Mice; Mitoguazone; Neoplasms, Experimental; Ornithine; Polyamines; Stomach Neoplasms | 1982 |
alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin.
Topics: Alkynes; Animals; Antineoplastic Agents, Phytogenic; Carboxy-Lyases; Carcinogens; Diterpenes; Eflornithine; Female; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Ornithine; Ornithine Decarboxylase Inhibitors; Phorbol Esters; Polyamines; Skin; Skin Neoplasms; Terpenes; Tetradecanoylphorbol Acetate | 1982 |
Difluoromethylornithine (DFMO), an inhibitor of nitrite production by macrophages?
Topics: Animals; Cell Line; Eflornithine; Kinetics; Lipopolysaccharides; Macrophages; Mice; Nitric Oxide; Nitrites; Ornithine | 1994 |
Arginine and ornithine metabolizing enzymes in testosterone-induced hypertrophic mouse kidney.
Topics: Animals; Arginase; Arginine; Eflornithine; Enzyme Induction; Female; Folic Acid; Hypertrophy; Kidney; Male; Mice; Mice, Inbred Strains; Ornithine; Ornithine Decarboxylase; Ornithine-Oxo-Acid Transaminase; Putrescine; Quinazolines; Sex Factors; Testosterone | 1995 |
Fluorinated analogues of L-ornithine are powerful inhibitors of ornithine decarboxylase and cell growth of Leishmania infantum promastigotes.
Topics: Animals; Anthelmintics; Cell Division; Dose-Response Relationship, Drug; Eflornithine; Kinetics; Leishmania infantum; Ornithine; Ornithine Decarboxylase Inhibitors; Putrescine | 1995 |
Biosynthesis and selective export of 1,5-diaminopentane (cadaverine) in mycoplasma-free cultured mammalian cells.
Topics: Amino Acids; Animals; Biological Transport; Cadaverine; Carcinoma, Hepatocellular; Cell Line; Culture Media; Eflornithine; Insulin; Kinetics; Lipopolysaccharides; Lysine; Mice; Mycoplasma; Ornithine; Putrescine; Rats; Spectrometry, Mass, Fast Atom Bombardment; Tumor Cells, Cultured | 1994 |
Regulation of putrescine export in lipopolysaccharide or IFN-gamma-activated murine monocytic-leukemic RAW 264 cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Animals; DNA; Dose-Response Relationship, Drug; Eflornithine; Inflammation; Interferon-gamma; Leukemia, Myeloid; Lipopolysaccharides; Macrophages; Male; Mice; Mice, Inbred BALB C; Ornithine; Ornithine Decarboxylase; Putrescine; Tumor Cells, Cultured; Verapamil | 1994 |
Endothelial polyamine uptake: selective stimulation by L-arginine deprivation or polyamine depletion.
Topics: Animals; Arginine; Biological Transport; Eflornithine; Endothelium, Vascular; Ornithine; Polyamines; Putrescine; Swine; Time Factors | 1994 |
Resistance to DL-alpha-difluoromethylornithine by clinical isolates of Trypanosoma brucei rhodesiense. Role of S-adenosylmethionine.
Topics: Animals; Drug Resistance, Microbial; Eflornithine; Mice; Ornithine; Polyamines; S-Adenosylmethionine; Trypanosoma brucei rhodesiense; Trypanosomiasis | 1993 |
Polyamines in Trypanosoma cruzi.
Topics: Agmatine; Animals; Arginine; Carboxy-Lyases; Eflornithine; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Protozoan Proteins; Putrescine; Trypanosoma cruzi | 1993 |
Catecholamines are required for androgen-induced ODC expression but not for hypertrophy of mouse kidney.
Topics: Animals; Arginine; Catecholamines; Eflornithine; Enzyme Induction; Female; Gene Expression Regulation; Hypertrophy; Kidney; Mice; Ornithine; Ornithine Decarboxylase; Reserpine; RNA, Messenger; Testosterone | 1997 |
Effect of ornithine in parenteral nutrition regimens on difluoromethylornithine-induced platelet suppression and changes in tumor polyamine content.
Topics: Animals; Arginine; Eflornithine; Hematocrit; Leukocyte Count; Male; Neoplasms, Experimental; Ornithine; Parenteral Nutrition; Platelet Count; Polyamines; Rats; Rats, Inbred F344 | 1998 |
Thrombin stimulates vascular smooth muscle cell polyamine synthesis by inducing cationic amino acid transporter and ornithine decarboxylase gene expression.
Topics: Amino Acid Transport Systems, Basic; Animals; Aorta, Thoracic; Biological Transport; Carrier Proteins; Cell Division; Cells, Cultured; Eflornithine; Enzyme Induction; Enzyme Inhibitors; Gene Expression Regulation; Male; Membrane Proteins; Muscle Proteins; Muscle, Smooth, Vascular; omega-N-Methylarginine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Rats; RNA, Messenger; Thrombin | 1998 |
Alpha-difluoromethylornithine (DFMO) as a potent arginase activity inhibitor in human colon carcinoma cells.
Topics: Animals; Antineoplastic Agents; Arginase; Arginine; Cattle; Eflornithine; Enzyme Inhibitors; HT29 Cells; Humans; Liver; Ornithine; Ornithine Decarboxylase Inhibitors | 1998 |
Ornithine decarboxylase along the mouse and rat nephron.
Topics: Animals; Arginase; Carbon Dioxide; Decarboxylation; Dose-Response Relationship, Drug; Eflornithine; Enzyme Inhibitors; Kidney Tubules, Proximal; Male; Mice; Nephrons; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Rats; Rats, Sprague-Dawley | 1998 |
Novel characteristics of Selenomonas ruminantium lysine decarboxylase capable of decarboxylating both L-lysine and L-ornithine.
Topics: Amino Acid Sequence; Bacterial Proteins; Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Kinetics; Lysine; Molecular Sequence Data; Ornithine; Selenomonas; Substrate Specificity | 1999 |
[Effect of polyamine synthesis inhibitors separately and in combination with epidermal growth factor on fusion of lysosomes with phagosomes and F-actin level in mouse peritoneal macrophages].
Topics: Actins; Animals; Antineoplastic Agents; Cells, Cultured; Eflornithine; Enzyme Inhibitors; Epidermal Growth Factor; Lysosomes; Macrophages, Peritoneal; Membrane Fusion; Mice; Mice, Inbred C57BL; Ornithine; Ornithine Decarboxylase Inhibitors; Phagosomes | 2000 |
Arginine decarboxylase as the source of putrescine for tobacco alkaloids.
Topics: Alkaloids; Arginine; Carboxy-Lyases; Eflornithine; Enzyme Inhibitors; Nicotiana; Nicotine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Plants, Toxic; Putrescine; Pyrrolidines | 1986 |
Activities of arginase I and II are limiting for endothelial cell proliferation.
Topics: Animals; Arginase; Cattle; Cell Division; Cells, Cultured; Coronary Vessels; Eflornithine; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Isoenzymes; Lac Operon; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Spermidine; Transfection | 2002 |
Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines.
Topics: Animals; Arginine; Chemotaxis, Leukocyte; Dexamethasone; Eflornithine; Enzyme Inhibitors; Glutamate-Ammonia Ligase; Glutamine; Hydrogen Peroxide; Isothiuronium; Male; Methionine Sulfoximine; Neutrophils; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Ornithine Decarboxylase Inhibitors; Polyamines; Rats; Rats, Sprague-Dawley; Respiratory Burst; Stress, Psychological | 2002 |
Metabolic and antiproliferative consequences of activated polyamine catabolism in LNCaP prostate carcinoma cells.
Topics: Acetyl Coenzyme A; Acetyltransferases; Adenosylmethionine Decarboxylase; Carcinoma; Cell Division; Deoxyadenosines; Eflornithine; Enzyme Inhibitors; Humans; Male; Methionine; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Polyamine Oxidase; Polyamines; Prostatic Neoplasms; Putrescine; RNA, Messenger; S-Adenosylmethionine; Tetracyclines; Thionucleosides; Tumor Cells, Cultured | 2004 |
Protective role of arginase in a mouse model of colitis.
Topics: Animals; Arginase; Arginine; Boronic Acids; Citrobacter rodentium; Colitis; Eflornithine; Enterobacteriaceae Infections; Enzyme Induction; Enzyme Inhibitors; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ornithine; Ornithine Decarboxylase; Polyamines | 2004 |
Albumin stimulates cell growth, l-arginine transport, and metabolism to polyamines in human proximal tubular cells.
Topics: Arginase; Arginine; Base Sequence; Biological Transport, Active; Cell Division; Cell Line; Eflornithine; Enzyme Inhibitors; Gene Expression; Homeostasis; Humans; Kidney Tubules, Proximal; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Recombinant Proteins; RNA, Messenger; Serum Albumin; Up-Regulation | 2005 |
Polyamines upregulate the mRNA expression of cationic amino acid transporter-1 in human retinal pigment epithelial cells.
Topics: Animals; Cationic Amino Acid Transporter 1; Cell Line; Dose-Response Relationship, Drug; Eflornithine; Enzyme Inhibitors; Epithelial Cells; Humans; Large Neutral Amino Acid-Transporter 1; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ornithine-Oxo-Acid Transaminase; Pigment Epithelium of Eye; Proto-Oncogene Proteins c-myc; Putrescine; RNA Interference; RNA, Messenger; RNA, Small Interfering; Spermidine; Spermine; Swine; Telomerase; Time Factors; Transfection; Up-Regulation | 2007 |
Characterization of the Entamoeba histolytica ornithine decarboxylase-like enzyme.
Topics: Amino Acid Sequence; Blotting, Northern; Cloning, Molecular; Eflornithine; Electrophoresis, Gel, Pulsed-Field; Entamoeba histolytica; Enzyme Activation; Humans; Molecular Sequence Data; Open Reading Frames; Ornithine; Ornithine Decarboxylase; Phylogeny; Polyamines; Protozoan Proteins; Recombinant Proteins; Sequence Homology, Amino Acid; Substrate Specificity | 2008 |
Mathematical modelling of polyamine metabolism in bloodstream-form Trypanosoma brucei: an application to drug target identification.
Topics: Adenosylmethionine Decarboxylase; Animals; Computer Simulation; Eflornithine; Humans; Kinetics; Metabolic Networks and Pathways; Models, Chemical; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; S-Adenosylmethionine; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African | 2013 |
Increased ornithine-derived polyamines cause airway hyperresponsiveness in a mouse model of asthma.
Topics: Adolescent; Adult; Animals; Asthma; Disease Models, Animal; Eflornithine; Female; Humans; Hypersensitivity; Inflammation; Lung; Male; Methacholine Chloride; Mice; Middle Aged; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Ovalbumin; Polyamines; Spermine; Sputum; Young Adult | 2013 |
Hessian fly larval feeding triggers enhanced polyamine levels in susceptible but not resistant wheat.
Topics: Adenosylmethionine Decarboxylase; Amino Acids; Animals; Biosynthetic Pathways; Diptera; Eflornithine; Gene Expression Regulation, Plant; Genes, Plant; Herbivory; Larva; Models, Biological; Ornithine; Ornithine Decarboxylase; Phylogeny; Plant Diseases; Polyamines; RNA, Messenger; Triticum; Virulence | 2015 |
A Label-Free Continuous Fluorescence-Based Assay for Monitoring Ornithine Decarboxylase Activity with a Synthetic Putrescine Receptor.
Topics: Biological Assay; Cell Line; Eflornithine; Fluorescence; Fluorescent Dyes; HEK293 Cells; Humans; Kinetics; Ornithine; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Polyamines; Putrescine; Receptors, Artificial | 2017 |
Ornithine uptake and the modulation of drug sensitivity in
Topics: Animals; Antineoplastic Agents; Eflornithine; Humans; Ornithine; Ornithine Decarboxylase; Polyamines; Trypanosoma brucei brucei; Trypanosomiasis, African | 2017 |