ornithine has been researched along with aminopterin in 10 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 3 (30.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bader, H; Forsch, RA; Freisheim, JH; Rosowsky, A | 1 |
| Freisheim, JH; Hynes, JB; Patil, SA; Shane, B; Singh, SK | 1 |
| Bader, H; Freisheim, JH; Moran, RG; Radike-Smith, M; Rosowsky, A; Solan, VC; Wright, JE | 1 |
| Bader, H; Cucchi, CA; Freisheim, JH; Kohler, W; Moran, RG; Rosowsky, A | 1 |
| Bader, H; Forsch, RA; Freisheim, JH; Moran, RG; Rosowsky, A; Solan, VC | 1 |
| Bader, H; Keyomarsi, K; Matherly, LH; Rosowsky, A; Wright, JE | 1 |
| Rosowsky, A | 1 |
| Forsch, RA; Rosowsky, A; Vaidya, CM; Wright, JE | 1 |
| Chen, YN; Rosowsky, A; Wright, JE; Yurasek, GK | 1 |
| Adamson, PC; Norris, RE | 1 |
1 review(s) available for ornithine and aminopterin
| Article | Year |
|---|---|
PT523 and other aminopterin analogs with a hemiphthaloyl-L-ornithine side chain: exceptionally tight-binding inhibitors of dihydrofolate reductase which are transported by the reduced folate carrier but cannot form polyglutamates.
Topics: Aminopterin; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; DNA Damage; Folic Acid Antagonists; Humans; Ornithine; Polyglutamic Acid; Pterins; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tissue Distribution | 1999 |
9 other study(ies) available for ornithine and aminopterin
| Article | Year |
|---|---|
Synthesis and in vitro biological activity of new deaza analogues of folic acid, aminopterin, and methotrexate with an L-ornithine side chain.
Topics: Aminopterin; Antineoplastic Agents; Cell Division; Cell Line; Chromatography, High Pressure Liquid; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Humans; Indicators and Reagents; Magnetic Resonance Spectroscopy; Methotrexate; Molecular Structure; Ornithine; Spectrophotometry; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1991 |
Inhibition of mammalian folylpolyglutamate synthetase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin bearing a terminal L-ornithine.
Topics: Aminopterin; Animals; Chemical Phenomena; Chemistry; Folic Acid; Folic Acid Antagonists; Humans; Kinetics; Liver; Ornithine; Oxidation-Reduction; Peptide Synthases; Substrate Specificity; Swine | 1989 |
Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain.
Topics: Aminobutyrates; Aminopterin; Animals; beta-Alanine; Cell Division; Folic Acid Antagonists; Glutamates; Glutamic Acid; Kinetics; Leukemia L1210; Methotrexate; Mice; Molecular Weight; Ornithine; Peptide Synthases | 1986 |
Methotrexate analogues. 33. N delta-acyl-N alpha-(4-amino-4-deoxypteroyl)-L-ornithine derivatives: synthesis and in vitro antitumor activity.
Topics: Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Humans; Leukemia L1210; Methotrexate; Mice; Neoplasms, Experimental; Ornithine; Peptide Synthases; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 1988 |
Synthesis and biologic activity of new side-chain-altered methotrexate and aminopterin analogs with dual inhibitory action against dihydrofolate reductase and folylpolyglutamate synthetase.
Topics: Aminobutyrates; Aminopterin; Animals; Cell Division; Folic Acid Antagonists; Growth Inhibitors; Leukemia L1210; Liver; Methotrexate; Mice; Ornithine; Peptide Synthases; Structure-Activity Relationship | 1987 |
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Folic Acid Antagonists; Humans; Methotrexate; Mice; Ornithine; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
The effect of side-chain, para-aminobenzoyl region, and B-ring modifications on dihydrofolate reductase binding, influx via the reduced folate carrier, and cytotoxicity of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta
Topics: 4-Aminobenzoic Acid; Aminopterin; Antineoplastic Agents; Binding Sites; Cell Division; Drug Resistance, Multiple; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Humans; Ornithine; Pterins; Reducing Agents; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 2000 |
Further studies on the interaction of nonpolyglutamatable aminopterin analogs with dihydrofolate reductase and the reduced folate carrier as determinants of in vitro antitumor activity.
Topics: Amino Acids; Aminopterin; Antineoplastic Agents; Carboxylic Acids; Carrier Proteins; Humans; Membrane Transport Proteins; Ornithine; Pterins; Reduced Folate Carrier Protein; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 2003 |
Clinical potency of methotrexate, aminopterin, talotrexin and pemetrexed in childhood leukemias.
Topics: Aminopterin; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Child; Dose-Response Relationship, Drug; Folic Acid Antagonists; Glutamates; Guanine; Humans; Inhibitory Concentration 50; Jurkat Cells; Leukemia; Lymphoma; Methotrexate; Molecular Structure; Ornithine; Pemetrexed; Pterins | 2010 |