orlistat and sinensetin

orlistat has been researched along with sinensetin* in 1 studies

Other Studies

1 other study(ies) available for orlistat and sinensetin

ArticleYear
Drug-guided screening for pancreatic lipase inhibitors in functional foods.
    Food & function, 2021, May-21, Volume: 12, Issue:10

    Chronic diseases, such as obesity, cause great harm to human health. Conventional drugs have promising therapeutic effects but also cause significant side effects. Functional foods are an excellent therapeutic alternative to pharmaceuticals, as they have fewer side effects. However, screening for active ingredients in natural foods is difficult. In this study, a novel pancreatic lipase inhibitor screening strategy, guided by the drug molecule orlistat, was combined with experimental verification. Twenty compounds from natural foods were evaluated based on the characteristics of orlistat interaction with pancreatic lipase. The characteristics of 13 molecules were comparable to those of orlistat. The pancreatic lipase inhibition rates of curcumin and sinensetin were 82.42 ± 0.50% and 81.07 ± 2.05%, respectively, and their IC

    Topics: Animals; Anti-Obesity Agents; Cholesterol; Drug Evaluation, Preclinical; Enzyme Inhibitors; Flavonoids; Functional Food; Lipase; Lipids; Liver; Male; Mice; Mice, Inbred C57BL; Molecular Dynamics Simulation; Obesity; Orlistat; Pancreas; Triglycerides; Weight Gain

2021