orlistat and benzimidazole

orlistat has been researched along with benzimidazole* in 2 studies

Reviews

1 review(s) available for orlistat and benzimidazole

Article	Year
Anti- Journal of medicinal chemistry, 2020, 11-25, Volume: 63, Issue:22 Topics: Animals; Antiprotozoal Agents; Benzimidazoles; Drug Delivery Systems; Drug Discovery; Drug Therapy, Combination; Gastrointestinal Tract; Giardia; Giardiasis; Humans; Nitroimidazoles	2020

Other Studies

1 other study(ies) available for orlistat and benzimidazole

Article	Year
Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors. Bioorganic & medicinal chemistry letters, 2012, Dec-15, Volume: 22, Issue:24 A novel series of benzimidazole derivatives was prepared and evaluated for their diacylglycerol acyltransferase (DGAT) inhibitory activity using microsome from rat liver. Among the newly synthesized compounds, furfurylamine containing benzimidazole carboxamide 10j showed the most potent DGAT inhibitory effect (IC(50)=4.4 μM) and inhibited triglyceride formation in HepG2 cells. Furthermore, compound 10j reduced body weight gain of Institute of Cancer Research mice on a high-fat diet and decreased levels of total triglyceride, total cholesterol, and LDL-cholesterol in the blood accompanied with a significant increase in HDL-cholesterol level. Topics: Animals; Benzimidazoles; Diacylglycerol O-Acyltransferase; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Hep G2 Cells; Humans; Mice; Mice, Obese; Microsomes, Liver; Molecular Structure; Obesity; Rats; Structure-Activity Relationship; Triglycerides	2012

Article

Year

Discovery of a novel series of benzimidazole derivatives as diacylglycerol acyltransferase inhibitors.

Bioorganic & medicinal chemistry letters, 2012, Dec-15, Volume: 22, Issue:24

A novel series of benzimidazole derivatives was prepared and evaluated for their diacylglycerol acyltransferase (DGAT) inhibitory activity using microsome from rat liver. Among the newly synthesized compounds, furfurylamine containing benzimidazole carboxamide 10j showed the most potent DGAT inhibitory effect (IC(50)=4.4 μM) and inhibited triglyceride formation in HepG2 cells. Furthermore, compound 10j reduced body weight gain of Institute of Cancer Research mice on a high-fat diet and decreased levels of total triglyceride, total cholesterol, and LDL-cholesterol in the blood accompanied with a significant increase in HDL-cholesterol level.

Topics: Animals; Benzimidazoles; Diacylglycerol O-Acyltransferase; Dose-Response Relationship, Drug; Drug Discovery; Enzyme Inhibitors; Hep G2 Cells; Humans; Mice; Mice, Obese; Microsomes, Liver; Molecular Structure; Obesity; Rats; Structure-Activity Relationship; Triglycerides

2012