orlistat has been researched along with allyl-alcohol* in 1 studies
1 other study(ies) available for orlistat and allyl-alcohol
| Article | Year |
|---|---|
Total synthesis of tetrahydrolipstatin and stereoisomers via a highly regio- and diastereoselective carbonylation of epoxyhomoallylic alcohols.
A concise enantioselective synthesis of tetrahydrolipstatin (THL) and seven stereoisomers has been achieved. The synthesis of THL was accomplished in 10 steps and 31% overall yield from an achiral ynone. Key to the success of the approach is the use of a bimetallic [Lewis acid](+)[Co(CO)4](-) catalyst for a late-stage regioselective carbonylation of an enantiomerically pure cis-epoxide to a trans-β-lactone. The success of this route to THL and its stereoisomers also demonstrated the practicality of the carbonylation catalyst for complex molecule synthesis as well as its functional group compatibility. Topics: Anti-Obesity Agents; Enzyme Inhibitors; Epoxy Compounds; Lactones; Orlistat; Propanols; Stereoisomerism | 2014 |