oridonin and enmein

oridonin has been researched along with enmein* in 1 studies

Other Studies

1 other study(ies) available for oridonin and enmein

Article	Year
Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation. European journal of medicinal chemistry, 2019, Jun-01, Volume: 171 A series of enmein-type diterpenoid amino acid ester derivatives (14-22) were designed and synthesized according to l-alanine-(14-oridonin) ester trifluoroacetate (clinical candidate HAO472). Their antiproliferative activities were tested against SGC-7901, Bel-7402, HL-60, PC-3, A549 and K562 cancer cell lines and L-02 normal liver cells. The results showed that compound 19 possessed the most potent cytotoxicity with IC Topics: Alanine; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Diterpenes; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Mitochondria; Molecular Structure; Structure-Activity Relationship	2019

Article

Year

Effective enmein-type mimics of clinical candidate HAO472: Design, synthesis and biological evaluation.

European journal of medicinal chemistry, 2019, Jun-01, Volume: 171

A series of enmein-type diterpenoid amino acid ester derivatives (14-22) were designed and synthesized according to l-alanine-(14-oridonin) ester trifluoroacetate (clinical candidate HAO472). Their antiproliferative activities were tested against SGC-7901, Bel-7402, HL-60, PC-3, A549 and K562 cancer cell lines and L-02 normal liver cells. The results showed that compound 19 possessed the most potent cytotoxicity with IC

Topics: Alanine; Antineoplastic Agents; Cell Cycle Checkpoints; Cell Line; Cell Proliferation; Diterpenes; Diterpenes, Kaurane; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Mitochondria; Molecular Structure; Structure-Activity Relationship

2019