organophosphonates has been researched along with sphingosine in 30 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (sphingosine) | Trials (sphingosine) | Recent Studies (post-2010) (sphingosine) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 8,325 | 117 | 3,459 |
| Protein | Taxonomy | organophosphonates (IC50) | sphingosine (IC50) |
|---|---|---|---|
| ubiquitin-conjugating enzyme E2 N | Homo sapiens (human) | 6.3125 | |
| cAMP-dependent protein kinase catalytic subunit alpha | Rattus norvegicus (Norway rat) | 0.098 | |
| Sphingosine kinase 2 | Homo sapiens (human) | 1.56 | |
| Sphingosine kinase 1 | Homo sapiens (human) | 3.86 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (13.33) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (23.33) | 29.6817 |
| 2010's | 19 (63.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dearborn, DG; Korn, ED; Smith, S | 1 |
| Karlsson, KA; Samuelsson, BE | 1 |
| Grol, M; Stoffel, W | 1 |
| Hayashi, A; Matsuura, F | 1 |
| Bergstrom, J; Card, D; Hajdu, R; Hale, J; Keohane, C; Lynch, CL; Mandala, S; Milligan, J; Parsons, W; Quackenbush, E; Rosen, H; Rosenbach, M; Rupprecht, K; Shei, GJ; Thornton, R; Xie, J | 1 |
| Bittman, R; Sun, C | 1 |
| Cahalan, MD; Cheng, WC; Don, A; Gonzalez-Cabrera, PJ; Jo, E; Marsolais, D; Matheu, MP; Parker, I; Rosen, H; Sanna, MG; Wang, SK; Wei, SH; Wong, CH | 1 |
| Schultz, C | 1 |
| Chen, LY; Logun, C; Nagineni, S; Shelhamer, JH; Woszczek, G | 1 |
| Bittman, R; Liu, J; Lu, X; Shuyu, E; Sun, C; Tigyi, G; Valentine, WJ | 1 |
| Bittman, R; Camp, SM; Chiang, ET; Dudek, SM; Garcia, JG; Harbeck, M; Lu, X; Mirzapoiazova, T; Moreno-Vinasco, L; Natarajan, V; Roe, M; Sammani, S; Sun, C | 1 |
| Baker, DL; Bittman, R; E, S; Gotoh, M; Kiss, GN; Liu, J; Lu, X; Murakami-Murofushi, K; Parrill, AL; Pham, TC; Pyne, NJ; Sun, C; Tigyi, G; Valentine, WJ | 1 |
| Bittman, R; Lim, KG; Long, J; Loveridge, C; Pitson, SM; Pyne, NJ; Pyne, S; Tigyi, G; Tonelli, F | 1 |
| He, P; Qian, Y; Xu, S; Zhang, G | 1 |
| Chen, Z; Doyle, T; Finley, A; Salvemini, D | 1 |
| Chen, Z; Doyle, T; Obeid, LM; Salvemini, D | 1 |
| Bittman, R; Pyne, NJ; Pyne, S | 1 |
| Lima, S; Parrill, AL; Spiegel, S | 1 |
| Chi, XX; Li, C; Nicol, GD; Strong, JA; Xie, W; Zhang, JM | 1 |
| Brown, JD; Francis, SA; Michel, T; Natarajan, P; Plutzky, J; Rader, DJ; Saghatelian, A; Tatematsu, S | 1 |
| Bieberich, E; Bryant, L; Chen, C; Chen, Z; Cuzzocrea, S; Doyle, T; Esposito, E; Janes, K; Kamocki, K; Li, C; Little, JW; Neumann, WL; Nicol, G; Obeid, L; Petrache, I; Salvemini, D; Snider, A | 1 |
| Ferreirós, N; Geisslinger, G; Henke, M; Linke, B; Scholich, K; Schreiber, Y; Stark, H; Suo, J; Zhang, DD; Zivkovic, A | 1 |
| Bittman, R; Dudek, SM; Garcia, JG; Wang, L | 1 |
| Guerrero, M; Kays, J; Li, C; Li, JN; Nicol, GD | 1 |
| Attiori Essis, S; Cyr, M; Laurier-Laurin, ME; Massicotte, G; Pépin, É | 1 |
| Cotta-de-Almeida, V; Lemos, JP; Mendes-da-Cruz, DA; Messias, CV; Moreira, OC; Santana-Van-Vliet, E; Savino, W | 1 |
| Klöckl, L; Schuchardt, M; Tölle, M; van der Giet, M; Wiedon, A; Zidek, W | 1 |
| Böhm, A; Dannenberg, L; Kelm, M; Knoop, B; Levkau, B; Polzin, A; Rauch, BH; Zeus, T; Zurek, M | 1 |
| Fu, J; Gao, F; Gao, Y; Li, Y; Meng, F; Yang, C | 1 |
| Chung, H; Jo, DI; Jung, SH; Kim, B; Kim, SH; Ko, HM; Lee, DH; Lee, SH; Song, YK | 1 |
1 review(s) available for organophosphonates and sphingosine
| Article | Year |
|---|---|
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.
Topics: Allosteric Regulation; Animals; Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Fingolimod Hydrochloride; Humans; Lysophospholipids; Mice; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Sphingosine; Vinyl Compounds | 2011 |
29 other study(ies) available for organophosphonates and sphingosine
| Article | Year |
|---|---|
Lipophosphonoglycan of the plasma membrane of A canthamoeba castellanii. Inositol and phytosphingosine content and general structural features.
Topics: Amoeba; Cell Membrane; Ceramides; Fatty Acids; Glycosphingolipids; Hexoses; Inositol; Organophosphonates; Phosphates; Sphingosine | 1976 |
The structure of ceramide aminoethylphosphonate from the sea anemone, Metridium senile.
Topics: Animals; Ceramides; Chromatography; Chromatography, Gas; Chromatography, Thin Layer; Clostridium perfringens; Cnidaria; Ethylamines; Fatty Acids; Fatty Acids, Unsaturated; Mass Spectrometry; Organophosphonates; Palmitic Acids; Phospholipases; Seasons; Silicon Dioxide; Sphingosine | 1974 |
Chemistry and biochemistry of 1-desoxysphinganine 1-phosphonate (dihydrosphingosine-1-phosphonate).
Topics: Aldehyde-Lyases; Animals; Kinetics; Liver; Microsomes; Models, Chemical; Organophosphonates; Rats; Sphingosine | 1974 |
Isolation of a new sphingophosphonolipid containing galactose from the viscera of Turbo cornutus.
Topics: Animals; Chromatography; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Thin Layer; Fatty Acids; Hydrolysis; Infrared Rays; Intestines; Methylamines; Organophosphonates; Palmitic Acids; Phospholipases; Snails; Spectrophotometry; Sphingolipids; Sphingosine | 1971 |
Alteration of lymphocyte trafficking by sphingosine-1-phosphate receptor agonists.
Topics: Animals; B-Lymphocytes; Binding, Competitive; Calcium; CHO Cells; Cricetinae; Cyclic AMP; Fingolimod Hydrochloride; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Immunosuppressive Agents; Ligands; Lymph Nodes; Lymphocyte Count; Lymphopenia; Lysophospholipids; Mice; Organophosphates; Organophosphonates; Phosphorylation; Propylene Glycols; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Spleen; Stereoisomerism; T-Lymphocytes | 2002 |
An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with alpha-lithiated alkylphosphonic esters.
Topics: Catalysis; Esters; Ethylene Oxide; Lithium; Lysophospholipids; Molecular Structure; Organophosphonates; Sphingolipids; Sphingosine; Stereoisomerism; Sulfonic Acids | 2004 |
Enhancement of capillary leakage and restoration of lymphocyte egress by a chiral S1P1 antagonist in vivo.
Topics: Anilides; Animals; Capillary Permeability; Cells, Cultured; CHO Cells; Cricetinae; Disease Models, Animal; Evans Blue; Humans; Lymph Nodes; Lymphocytes; Lysophospholipids; Mice; Mice, Inbred C57BL; Models, Biological; Organophosphonates; Phenotype; Pulmonary Edema; Receptors, Lysosphingolipid; Sphingosine; Stereoisomerism | 2006 |
Lipid-induced phenotypes.
Topics: Anilides; Animals; Binding Sites; Humans; Lysophospholipids; Models, Biological; Organophosphonates; Phenotype; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2006 |
Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Calcium; Calcium Signaling; Cell Line; Eicosanoids; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Group IV Phospholipases A2; Humans; Lung; Lysophospholipids; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Respiratory Mucosa; rho-Associated Kinases; RNA, Small Interfering; Sphingosine | 2008 |
Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.
Topics: Animals; Cells, Cultured; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Intestinal Mucosa; Molecular Structure; Organophosphonates; Propylene Glycols; Receptors, Lysosphingolipid; Sphingosine; Stereoisomerism; Vinyl Compounds | 2009 |
Synthetic analogs of FTY720 [2-amino-2-(2-[4-octylphenyl]ethyl)-1,3-propanediol] differentially regulate pulmonary vascular permeability in vivo and in vitro.
Topics: Animals; Capillary Permeability; Cell Line; Fingolimod Hydrochloride; Humans; Inflammation Mediators; Lung; Mice; Mice, Inbred C57BL; Organophosphonates; Propylene Glycols; Pulmonary Artery; Sphingosine | 2009 |
(S)-FTY720-vinylphosphonate, an analogue of the immunosuppressive agent FTY720, is a pan-antagonist of sphingosine 1-phosphate GPCR signaling and inhibits autotaxin activity.
Topics: Animals; Cell Line; Humans; Lysophospholipids; Mice; Mice, Inbred C57BL; Organophosphates; Organophosphonates; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Stereoisomerism; Vinyl Compounds | 2010 |
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Topics: Androgens; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Humans; Male; Muscle, Smooth, Vascular; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Pulmonary Artery; Sphingosine; Stereoisomerism; Vinyl Compounds | 2010 |
Sphingosine-1-phosphate prevents permeability increases via activation of endothelial sphingosine-1-phosphate receptor 1 in rat venules.
Topics: Anilides; Animals; Calcium; Capillary Permeability; Endothelium, Vascular; Female; Lysophospholipids; Mesentery; Models, Animal; Organophosphonates; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Venules | 2010 |
Role for peroxynitrite in sphingosine-1-phosphate-induced hyperalgesia in rats.
Topics: Acetophenones; Anilides; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Activation; Enzyme Inhibitors; Hyperalgesia; Lysophospholipids; Male; Metalloporphyrins; NG-Nitroarginine Methyl Ester; Organophosphonates; Oxadiazoles; Peroxynitrous Acid; Rats; Rats, Sprague-Dawley; Reaction Time; Receptors, Lysosphingolipid; Sphingosine; Thiophenes; Time Factors | 2011 |
Sphingosine-1-phosphate acting via the S1P₁ receptor is a downstream signaling pathway in ceramide-induced hyperalgesia.
Topics: Anilides; Animals; Ceramides; Hyperalgesia; Inflammation Mediators; Injections, Subcutaneous; Lysophospholipids; Male; Mice; Organophosphonates; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2011 |
Structure of the first sphingosine 1-phosphate receptor.
Topics: Anilides; Binding Sites; Crystallography, X-Ray; Drug Design; Humans; Indans; Lysophospholipids; Models, Molecular; Organophosphonates; Oxadiazoles; Protein Binding; Protein Conformation; Receptors, Lysosphingolipid; Sphingosine | 2012 |
Sphingosine 1-phosphate receptor 2 antagonist JTE-013 increases the excitability of sensory neurons independently of the receptor.
Topics: Action Potentials; Analysis of Variance; Anilides; Animals; Capsaicin; Cell Line, Tumor; Cell Movement; Dinoprostone; Dose-Response Relationship, Drug; Drug Interactions; Ganglia, Spinal; Guanosine Diphosphate; Hyperalgesia; Lysophospholipids; Male; Melanoma; Mice; Organophosphonates; Pain Threshold; Patch-Clamp Techniques; Pertussis Toxin; Pyrazoles; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sensory Receptor Cells; Sensory System Agents; Sphingosine; Thionucleotides; Time Factors; Wound Healing | 2012 |
Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium.
Topics: Anilides; Animals; Cell Movement; Cell Proliferation; Cells, Cultured; Cholesterol; Endothelium, Vascular; Lipase; Lipoproteins, HDL; Lysophospholipids; Mice; Mice, Knockout; Neovascularization, Physiologic; Nitric Oxide Synthase Type III; Organophosphonates; Phosphorylation; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine | 2013 |
The development and maintenance of paclitaxel-induced neuropathic pain require activation of the sphingosine 1-phosphate receptor subtype 1.
Topics: Anilides; Animals; Antineoplastic Agents, Phytogenic; Cytokines; Enzyme Activation; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Indans; Lysophospholipids; Male; Neuralgia; Organophosphonates; Oxadiazoles; Paclitaxel; Propylene Glycols; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazoles; Thiophenes | 2014 |
Antinociceptive effects of FTY720 during trauma-induced neuropathic pain are mediated by spinal S1P receptors.
Topics: Analgesics; Anilides; Animals; In Situ Hybridization; Lysophospholipids; Male; Mice; Neuralgia; Organophosphates; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Wounds and Injuries | 2015 |
Junctional complex and focal adhesion rearrangement mediates pulmonary endothelial barrier enhancement by FTY720 S-phosphonate.
Topics: Acute Lung Injury; Antigens, CD; Antigens, Nuclear; Cadherins; Endothelial Cells; Fingolimod Hydrochloride; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Humans; Immunosuppressive Agents; Lung; Lysophospholipids; Microscopy, Fluorescence; Nerve Tissue Proteins; Organophosphonates; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Receptors, Lysosphingolipid; RNA, Small Interfering; Sphingosine; Transcription Factors; Zonula Occludens-1 Protein | 2015 |
Sphingosine 1-phosphate enhances the excitability of rat sensory neurons through activation of sphingosine 1-phosphate receptors 1 and/or 3.
Topics: Action Potentials; Anilides; Animals; Cells, Cultured; Dinoprostone; Enzyme Inhibitors; Fingolimod Hydrochloride; Ganglia, Spinal; Gene Expression Regulation; Immunosuppressive Agents; Lysophospholipids; Mice; Mice, Inbred C57BL; Organophosphonates; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; RNA, Small Interfering; Sensory Receptor Cells; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazolidines | 2015 |
GluN2B-containing NMDA receptors are upregulated in plasma membranes by the sphingosine-1-phosphate analog FTY720P.
Topics: Analysis of Variance; Anilides; Animals; Biotinylation; Cell Membrane; Enzyme Inhibitors; Hippocampus; In Vitro Techniques; Lysophospholipids; Male; Organophosphates; Organophosphonates; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Receptors, N-Methyl-D-Aspartate; Sphingosine; Sphingosine-1-Phosphate Receptors; src-Family Kinases; Time Factors; Transcriptional Activation; Up-Regulation | 2015 |
Sphingosine-1-Phosphate Induces Dose-Dependent Chemotaxis or Fugetaxis of T-ALL Blasts through S1P1 Activation.
Topics: Anilides; Cell Line, Tumor; Chemotaxis; Gene Expression Regulation, Leukemic; Humans; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organophosphonates; Phosphorylation; Proto-Oncogene Proteins c-akt; rac1 GTP-Binding Protein; Receptors, Lysosphingolipid; RNA, Messenger; Signal Transduction; Sphingosine; T-Lymphocytes | 2016 |
Regulation of endothelial nitric oxide synthase activation in endothelial cells by S1P1 and S1P3.
Topics: Anilides; beta-Alanine; Endothelial Cells; Enzyme Activation; Gene Knockdown Techniques; Human Umbilical Vein Endothelial Cells; Humans; Nitric Oxide; Nitric Oxide Synthase Type III; Organophosphates; Organophosphonates; Phosphorylation; Phosphoserine; Proto-Oncogene Proteins c-akt; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thiazolidines; Thiophenes | 2016 |
Aspirin Inhibits Platelet-Derived Sphingosine-1-Phosphate Induced Endothelial Cell Migration.
Topics: Anilides; Aspirin; Blood Platelets; Cell Movement; Cells, Cultured; Human Umbilical Vein Endothelial Cells; Humans; Lysophospholipids; Organophosphonates; Receptors, Lysosphingolipid; Sphingosine | 2018 |
The Sphingosine 1-Phosphate Analogue FTY720 Alleviates Seizure-induced Overexpression of P-Glycoprotein in Rat Hippocampus.
Topics: Anilides; Animals; Anticonvulsants; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cyclooxygenase 2; Disease Models, Animal; Drug Resistant Epilepsy; Fingolimod Hydrochloride; Hippocampus; Humans; Immunosuppressive Agents; Injections, Intraperitoneal; Lysophospholipids; Male; Organophosphonates; Phenytoin; Pilocarpine; Rats; Rats, Sprague-Dawley; Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Up-Regulation | 2018 |
Association between sphingosine-1-phosphate-induced signal transduction via mitogen-activated protein kinase pathways and keloid formation.
Topics: Adult; Anilides; Anthracenes; Cell Line; Collagen Type I; Collagen Type I, alpha 1 Chain; Female; Fibroblasts; Flavonoids; Humans; Keloid; Lysophospholipids; Male; MAP Kinase Signaling System; Middle Aged; Mitogen-Activated Protein Kinases; Organophosphonates; Phosphorylation; Pyrazoles; Pyridines; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Young Adult | 2019 |