organophosphonates has been researched along with sphingosine kinase in 5 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (sphingosine kinase) | Trials (sphingosine kinase) | Recent Studies (post-2010) (sphingosine kinase) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 1,660 | 4 | 978 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, LY; Logun, C; Nagineni, S; Shelhamer, JH; Woszczek, G | 1 |
| Bittman, R; Lim, KG; Long, J; Loveridge, C; Pitson, SM; Pyne, NJ; Pyne, S; Tigyi, G; Tonelli, F | 1 |
| Bittman, R; Pyne, NJ; Pyne, S | 1 |
| Bittman, R; Liu, Z; MacRitchie, N; Pyne, NJ; Pyne, S | 1 |
| Birch, CA; Chen, B; Cisneros-Aguirre, M; Coronel, LJ; Gomez Menzies, PK; Grimsey, NJ; Lawson, MA; Lin, H; Molinar-Inglis, O; Nicholas, D; Orduña-Castillo, L; Patel, HH; Patwardhan, A; Trejo, J | 1 |
1 review(s) available for organophosphonates and sphingosine kinase
| Article | Year |
|---|---|
Sphingosine kinase inhibitors and cancer: seeking the golden sword of Hercules.
Topics: Allosteric Regulation; Animals; Antineoplastic Agents; Cell Division; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Fingolimod Hydrochloride; Humans; Lysophospholipids; Mice; Molecular Targeted Therapy; Neoplasm Metastasis; Neoplasm Proteins; Neoplasms; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Proteasome Endopeptidase Complex; Protein Kinase Inhibitors; Sphingosine; Vinyl Compounds | 2011 |
4 other study(ies) available for organophosphonates and sphingosine kinase
| Article | Year |
|---|---|
Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Asthma; Calcium; Calcium Signaling; Cell Line; Eicosanoids; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Group IV Phospholipases A2; Humans; Lung; Lysophospholipids; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Respiratory Mucosa; rho-Associated Kinases; RNA, Small Interfering; Sphingosine | 2008 |
FTY720 and (S)-FTY720 vinylphosphonate inhibit sphingosine kinase 1 and promote its proteasomal degradation in human pulmonary artery smooth muscle, breast cancer and androgen-independent prostate cancer cells.
Topics: Androgens; Antineoplastic Agents; Breast Neoplasms; Cell Line, Tumor; Cells, Cultured; Drug Resistance, Neoplasm; Enzyme Inhibitors; Female; Fingolimod Hydrochloride; Humans; Male; Muscle, Smooth, Vascular; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Propylene Glycols; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Pulmonary Artery; Sphingosine; Stereoisomerism; Vinyl Compounds | 2010 |
Synthesis of (S)-FTY720 vinylphosphonate analogues and evaluation of their potential as sphingosine kinase 1 inhibitors and activators.
Topics: Cells, Cultured; Dose-Response Relationship, Drug; HEK293 Cells; Humans; Molecular Structure; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Protein Kinase Inhibitors; Structure-Activity Relationship | 2013 |
aPC/PAR1 confers endothelial anti-apoptotic activity via a discrete, β-arrestin-2-mediated SphK1-S1PR1-Akt signaling axis.
Topics: Anilides; Apoptosis; beta-Arrestin 2; Endothelial Cells; Enzyme Inhibitors; Gene Expression Regulation; Heterocyclic Compounds, 3-Ring; Humans; Lactones; Methanol; Organophosphonates; Phosphotransferases (Alcohol Group Acceptor); Platelet Aggregation Inhibitors; Protein C; Proto-Oncogene Proteins c-akt; Pyridines; Pyrrolidines; Receptor, PAR-1; Sphingosine-1-Phosphate Receptors; Sulfones | 2021 |