organophosphonates has been researched along with pyrophosphate in 58 studies
Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (pyrophosphate) | Trials (pyrophosphate) | Recent Studies (post-2010) (pyrophosphate) |
---|---|---|---|---|---|
9,968 | 880 | 3,596 | 6,743 | 183 | 1,175 |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 44 (75.86) | 18.7374 |
1990's | 3 (5.17) | 18.2507 |
2000's | 6 (10.34) | 29.6817 |
2010's | 5 (8.62) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Broge, L; Felix, R; Fleisch, H; Hansen, NM; Monod, A | 1 |
Kaye, M; Rosenthall, L; Silverton, S | 1 |
Bonte, FJ; Graham, KD; Moore, JG; Parkey, RW | 1 |
Bessent, RG; Blumgart, L; Citrin, DL; elms, ST; Greig, WR; McGinlay, E; Tuohy, JB | 1 |
Fleisch, H; Russell, RG | 2 |
Halpern, SE; Preisman, R | 1 |
Orii, H; Oyamada, H; Sasaki, Y; Tabei, T | 1 |
Fleisch, H | 1 |
Brody, KR; Hosain, F; Hosain, P; Spencer, RP; Wagner, HN | 1 |
Bisaz, S; Felix, R; Fleisch, H; Hansen, NM | 1 |
Dolphin, DH; Fritzberg, AR; Lyster, DM | 1 |
Rossel's, AN; Shepeleva, II | 1 |
Felix, R; Fleisch, H | 1 |
Harris, WR; Nesset-Tollefson, D | 1 |
Rammler, DH; Yengoyan, L | 1 |
Bax, PC; Paul, AV; Rammler, DH; Yengoyan, L | 1 |
Bisaz, S; Fleisch, H; Mühlbauer, R; Russell, RG | 1 |
Bisaz, S; Casey, PA; Fleisch, H; Mühlbauer, RC; Russell, RG | 1 |
Fleisch, H; Francis, MD; Russell, RG | 1 |
Kimmerle, G; Lorke, D | 1 |
Bisaz, S; Fleisch, H; Russell, RG | 1 |
Mühlemann, HR; Regolati, B; Schmid, R | 1 |
Hotz, P; Regolati, B | 1 |
Berry, WK; Davies, DR; Gordon, JJ | 1 |
Cooperman, BS; Mark, DH | 1 |
Danenberg, PV; Santi, DV; Satterly, P | 1 |
Danenberg, PV; Montgomery, KA; Santi, DV | 1 |
Fleisch, H; Francis, MD; Morgan, DB; Robertson, WG | 1 |
Yasumura, S | 1 |
Heaney, R; Saville, PD | 1 |
Fleisch, H; Minkin, C; Morgan, DB; Reynolds, JJ; Spycher, D | 1 |
Bisaz, S; Fleisch, H; Jung, A | 1 |
Robertson, WG | 1 |
Hampton, A; Paul, B; Sasaki, T | 1 |
Nordin, BE; Peacock, M; Robertson, WG | 1 |
Chiu, NY; Coopermann, BS | 1 |
Butler, LG; Feldman, F; Kelly, SJ; Sperow, JW | 1 |
Bessent, RG; Blumgart, LH; Citrin, DL; Elms, ST; Greig, WR; McGinlay, E; Tuohy, JB | 1 |
Richards, P; Steigman, J | 1 |
Balser, D; Büll, U; Frey, KW | 1 |
Butler, LG; Kelly, SH; Sperow, JW | 1 |
Baumann, JM; Bisaz, S; Fleisch, H; Ganz, U; Rutishauser, G | 1 |
Keister, DL; Raveed, NJ | 1 |
Münzenberg, J; Reischauer, HC | 1 |
Bruchhaus, I; Denart, M; Jacobs, T; Tannich, E | 1 |
Chatterjee, S; Lakeman, FD; Nii, S; Tsukazaki, T; Whitley, RJ; Yamada, M; Yoshida, M | 1 |
Chamani, J; Hakimelahi, GH; Hakimelahi, S; Hassanzadeh, F; Jain, ML; Khodarahmi, GA; Kulatheeswaran, R; Luo, FT; Ly, TW; Moosavi-Movahedi, AA; Pasdar, M; Shia, KS; Xue, C; Yen, CF | 1 |
Birkus, G; Holy, A; Otmar, M; Rejman, D; Rosenberg, I; Votruba, I | 1 |
Evans, DH; Hostetler, KY; Magee, WC | 1 |
Himeno, S; Inazuma, N; Kitano, E | 1 |
Borden, J; Crans, DC; Florian, J; Goodman, MF; Holder, AA; Ismail, R; Kultyshev, R; Prakash, GK; Saha, TK; Yousufuddin, M | 1 |
Boojamra, CG; Callebaut, C; Cihlar, T; Gao, Y; Hui, H; Lin, KY; Mackman, RL; Ray, AS; Stray, K; Vela, JE; Zhang, L | 1 |
Dix, EJ; Wright, GE; Yanachkov, IB; Yanachkova, MI | 1 |
Bronsveld, W; Haverkort, ME; Huitema, AD; Lips, P; Slieker, WA; ter Heine, R; van der Spek, BW | 1 |
Anderson, PL; Bushman, LR; Kiser, JJ; Klein, B; Ray, ML; Rower, JE; Zheng, JH | 1 |
Adams, JL; Crucitti, T; De Baetselier, I; Fransen, K; Kashuba, AD; Menezes, P; Patterson, KB; Prince, HM; Sykes, C; Van Damme, L | 1 |
Eng, WS; Guddat, LW; Hocková, D; Janeba, Z; Keough, DT; Naesens, LM; Špaček, P; West, NP; Woods, K | 1 |
6 review(s) available for organophosphonates and pyrophosphate
Article | Year |
---|---|
Pyrophosphate and diphosphonates in skeletal metabolism. Physiological, clinical and therapeutic aspects.
Topics: Animals; Bone and Bones; Bone Resorption; Calcification, Physiologic; Calcinosis; Calcium; Calcium Metabolism Disorders; Cartilage; Chemical Phenomena; Chemistry; Culture Techniques; Depression, Chemical; Diphosphates; Etidronic Acid; Humans; Hydroxyapatites; Kidney Diseases; Methylene Chloride; Organophosphonates; Organophosphorus Compounds; Osteoporosis; Urinary Bladder Calculi; Vitamin D | 1975 |
[Mechanisms of phosphate radionuclide accumulation in a myocardial infarct focus].
Topics: Diphosphates; Drug Combinations; Heart; Humans; Myocardial Infarction; Myocardium; Organophosphonates; Phosphates; Radioisotopes; Radionuclide Imaging; Technetium; Tin | 1979 |
Pyrophosphate and diphosphonates in calcium metabolism and their possible role in renal failure.
Topics: Animals; Bone Diseases; Bone Resorption; Calcinosis; Calcium; Diphosphates; Homeostasis; Humans; Hydroxyapatites; Hyperparathyroidism, Secondary; Kidney Failure, Chronic; Organophosphonates; Osteogenesis; Osteomalacia; Rats; Renal Dialysis; Uremia | 1969 |
Physiological changes in metabolic disorders of bone and evaluation of agents used in their treatment.
Topics: Androgens; Bone Diseases; Diphosphates; Estrogens; Fluorides; Heparin; Humans; Hyperparathyroidism; Metabolic Diseases; Organophosphonates; Osteitis Deformans; Osteomalacia; Osteoporosis; Parathyroid Hormone; Phosphates; Plicamycin | 1972 |
Treatment of osteoporosis with diphosphonates.
Topics: Anemia; Diphosphates; Female; Humans; Menopause; Organophosphonates; Osteoclasts; Osteoporosis; Time Factors | 1972 |
Chemistry of technetium 99m.
Topics: Bone and Bones; Citrates; Colloids; Diphosphates; Erythrocytes; Gluconates; Isotope Labeling; Kidney; Mannitol; Organophosphonates; Pentetic Acid; Phosphates; Quality Control; Radionuclide Imaging; Serum Albumin; Sulfur; Technetium; Tin | 1974 |
1 trial(s) available for organophosphonates and pyrophosphate
Article | Year |
---|---|
A comparison of phosphate bone-scanning agents in normal subjects and patients with malignant disease.
Topics: Bone and Bones; Bone Neoplasms; Diphosphates; Humans; Male; Neoplasm Metastasis; Organophosphonates; Phosphates; Radiation Dosage; Radionuclide Imaging; Technetium; Whole-Body Counting | 1975 |
51 other study(ies) available for organophosphonates and pyrophosphate
Article | Year |
---|---|
Aggregation of calcium oxalate crystals: effect of urine and various inhibitors.
Topics: Calcium; Crystallization; Diphosphates; Diphosphonates; Humans; Hydrogen-Ion Concentration; Magnesium; Male; Molecular Weight; Organophosphonates; Oxalates; Phosphates; Proteinuria | 1977 |
Technetium-99m-pyrophosphate: studies in vivo and in vitro.
Topics: Animals; Bone and Bones; Borohydrides; Calcium; Calcium Radioisotopes; Diphosphates; Edetic Acid; Erythrocytes; Femur; Hyaluronoglucosaminidase; Hydrochloric Acid; In Vitro Techniques; Iron Radioisotopes; Organophosphonates; Phosphorus Radioisotopes; Rats; Rickets; Serum Albumin, Radio-Iodinated; Sodium Hydroxide; Technetium; Tibia | 1975 |
Distributions of several agents useful in imaging myocardial infarcts.
Topics: Animals; Bone and Bones; Diphosphates; Dogs; Fluorine; Liver; Lung; Myocardial Infarction; Myocardium; Organophosphonates; Phosphates; Radioisotopes; Radionuclide Imaging; Technetium | 1975 |
Effect of unilateral pulmonary hypovascularity on the bone scan: case report.
Topics: Aged; Bone Diseases; Diphosphates; Humans; Lung; Male; Organophosphonates; Radionuclide Imaging; Technetium | 1976 |
Bone scanning with 99m-Tc-phosphates: a comparison and problems in the detection of tumor metastasis.
Topics: Absorption; Adult; Age Factors; Aged; Bone Neoplasms; Diphosphates; Elementary Particles; Female; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Organophosphonates; Phosphates; Prostatic Neoplasms; Radionuclide Imaging; Technetium | 1976 |
[Treatment of Paget's disease using diphosphosphonates].
Topics: Chemical Phenomena; Chemistry; Diphosphates; Humans; In Vitro Techniques; Methods; Organophosphonates; Osteitis Deformans; Time Factors | 1975 |
Technetium-99m labelled imidodiphosphate: an improved bone-scanning radiopharmaceutical.
Topics: Animals; Bone and Bones; Bone Neoplasms; Diphosphates; Dogs; Female; Humans; Imides; Male; Mice; Middle Aged; Neoplasm Metastasis; Organophosphonates; Phosphates; Rabbits; Radionuclide Imaging; Technetium | 1976 |
Disaggregation of hydroxyapatite crystals.
Topics: Binding Sites; Citrates; Crystallization; Diphosphates; Glycosaminoglycans; Hydroxyapatites; Kinetics; Lactates; Organophosphonates; Protein Binding | 1976 |
Evaluation of formamidine sulfinic acid and other reducing agents for use in the preparation of Tc-99m labeled radiopharmaceuticals.
Topics: Amidines; Animals; Chlorides; Diphosphates; Hydrazines; Isotope Labeling; Mice; Organophosphonates; Oxidation-Reduction; Pentetic Acid; Rabbits; Radionuclide Imaging; Sulfinic Acids; Technetium; Tin | 1977 |
Properties of inorganic pyrophosphatase of pig scapula cartilage.
Topics: Amino Acids; Animals; Calcium; Cartilage; Cyanides; Diphosphates; Enzyme Activation; Fluorides; Formaldehyde; Hydrogen-Ion Concentration; Kinetics; Magnesium; Molecular Weight; Molybdenum; Organophosphonates; Pyrophosphatases; Scapula; Swine; Tartrates; Theophylline | 1975 |
Binding of phosphonate chelating agents and pyrophosphate to apotransferrin.
Topics: Animals; Apoproteins; Binding Sites; Chelating Agents; Diphosphates; Ferric Compounds; Kinetics; Ligands; Organophosphonates; Polyphosphates; Protein Conformation; Rabbits; Transferrin; X-Ray Diffraction | 1991 |
Nucleoside phosphonic acids. I. The synthesis of 5'-deoxyuridine 5'-phosphonic acids and derivatives.
Topics: Chemistry, Organic; Chromatography, Ion Exchange; Chromatography, Paper; Diphosphates; Organic Chemistry Phenomena; Organophosphonates; Uracil Nucleotides | 1966 |
Nucleoside phosphonic acids. II. The synthesis of 5'-deoxythymidine 5'-phosphonic acid and its pyrophosphate derivatives.
Topics: Anhydrides; Chemistry, Organic; Chromatography, Paper; Diphosphates; Electrophoresis; Escherichia coli; Kinetics; Nucleosides; Nucleotidyltransferases; Organic Chemistry Phenomena; Organophosphonates; Phosphates; Phosphorus Isotopes; Thymidine | 1967 |
[Influence of diphosphonates on the deposition and dissolution ofccalcium phosphate in vitro and in vivo].
Topics: Animals; Aorta; Calcinosis; Calcium Phosphates; Culture Techniques; Depression, Chemical; Diphosphates; Mice; Models, Biological; Nephrocalcinosis; Organophosphonates; Rats | 1968 |
The influence of pyrophosphate analogues (diphosphonates) on the precipitation and dissolution.
Topics: Animals; Aortic Diseases; Bone Resorption; Calcinosis; Calcium Phosphates; Chemical Phenomena; Chemical Precipitation; Chemistry; Cholecalciferol; Diphosphates; Hypercalcemia; Mice; Organophosphonates; Pyrophosphatases; Rats | 1968 |
Diphosphonates inhibit formation of calcium phosphate crystals in vitro and pathological calcification in vivo.
Topics: Animals; Aortic Diseases; Calcinosis; Cholecalciferol; Crystallization; Diphosphates; Hydrogen-Ion Concentration; Organophosphonates; Phosphates; Rats; X-Ray Diffraction | 1969 |
[Action of reactivators in phosphoric acid ester poisoning].
Topics: Animals; Antidotes; Atropine; Cholinesterase Inhibitors; Diphosphates; Humans; Organophosphonates; Parathion; Phosphoric Acids; Pralidoxime Compounds; Rats; Triazines | 1969 |
The effects of diphosphonate, pyrophosphate and sodium foride on drinking habits of Osborne-Mendel rats.
Topics: Animals; Dental Calculus; Diphosphates; Drinking Behavior; Fluorides; Organophosphonates; Rats | 1970 |
Effects of pyrophosphate and diphosphonate on fluoride uptake by hydroxyapatite.
Topics: Diphosphates; Fluorides; Humans; Hydroxyapatites; Models, Theoretical; Organophosphonates | 1970 |
Pyrophosphate, phosphonates and pyrophosphatases in the regulation of calcification and calcium homeostasis.
Topics: Animals; Bone and Bones; Calcification, Physiologic; Calcium; Diphosphates; Homeostasis; Humans; Organophosphonates; Pyrophosphatases | 1970 |
Protection of animals against soman (1,2,2-trimethylpropyl methylphosphono-fluoridate) by pretreatment with some other organophosphorus compounds, followed by oxime and atropine.
Topics: Amitriptyline; Animals; Atropine; Bromides; Carbamates; Cholinesterase Inhibitors; Diphosphates; Drug Antagonism; Female; Fluorine; Guinea Pigs; Hydroxamic Acids; Isoflurophate; Lethal Dose 50; Nitrates; Nitrophenols; Nitroso Compounds; Organophosphonates; Organophosphorus Compounds; Orphenadrine; Oximes; Parasympatholytics; Physostigmine; Poisoning; Pyridinium Compounds; Rabbits; Rats; Salicylates; Scopolamine; Species Specificity; Sulfonic Acids; Sulfuric Acids; Thiazoles; Time Factors | 1971 |
Aggregation in dilute solutions of Mn 2+ and inorganic pyrophosphate and its biochemical consequences.
Topics: Calcium; Chemical Phenomena; Chemistry; Diphosphates; Electron Spin Resonance Spectroscopy; Half-Life; Hydrolysis; Kinetics; Macromolecular Substances; Magnesium; Magnetic Resonance Spectroscopy; Manganese; Mathematics; Models, Chemical; Organophosphonates; Protons; Pyrophosphatases; Yeasts | 1971 |
Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Reaction parameters and order of substrate addition.
Topics: Acylation; Adenosine; Adenosine Triphosphate; Amino Acyl-tRNA Synthetases; Amino Alcohols; Carbon Isotopes; Catalysis; Diphosphates; Escherichia coli; Ethanol; Fluorine; Kinetics; Magnesium; Models, Chemical; Nucleosides; Organophosphonates; Oxidation-Reduction; Periodic Acid; Phenylalanine; Phosphorus Isotopes; Protein Binding; RNA, Transfer; Sodium Chloride; Structure-Activity Relationship | 1971 |
Phenylalanyl transfer ribonucleic acid synthetase from Escherichia coli. Analysis of the adenosine triphosphate binding site.
Topics: Acylation; Adenine; Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Alcohols; Amino Acyl-tRNA Synthetases; Binding Sites; Cyclohexanes; Deoxyadenosines; Diphosphates; Escherichia coli; Organophosphonates; Phosphoric Acids; Phosphorus Isotopes; Protein Binding; Purines; Structure-Activity Relationship; Thermodynamics | 1971 |
The effects of diphosphonates on the exchangeable and non-exchangeable calcium and phosphate of hydroxyapatite.
Topics: Calcium; Calcium Isotopes; Chemical Phenomena; Chemistry; Chlorine; Diphosphates; Ethanol; Filtration; Hydroxyapatites; Organophosphonates; Phosphates; Phosphorus Isotopes | 1971 |
The effect of two diphosphonates on the resorption of mouse calvaria in vitro.
Topics: Animals; Bone Resorption; Calcium Isotopes; Culture Techniques; Diphosphates; Frontal Bone; Mice; Mice, Inbred Strains; Organophosphonates; Parietal Bone; Phosphates; Scintillation Counting; Statistics as Topic; Time Factors | 1972 |
The binding of pyrophosphate and two diphosphonates by hydroxyapatite crystals.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Crystallization; Diphosphates; Hydroxyapatites; Organophosphonates; Time Factors | 1973 |
Factors affecting the precipitation of calcium phosphate in vitro.
Topics: Calcium; Calcium Phosphates; Crystallization; Diphosphates; Hydroxyapatites; Organophosphonates; Solubility; Solutions; Time Factors | 1973 |
Synthesis of 6'-cyano-6'-deoxyhomoadenosine-6'-phosphonic acid and its phosphoryl and pyrophosphoryl anhydrides and studies of their interactions with adenine nucleotide utilizing enzymes.
Topics: Adenine Nucleotides; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Aminohydrolases; Anhydrides; Animals; Binding Sites; Chemical Phenomena; Chemistry; Diphosphates; Enzyme Repression; Muscles; Nucleotidases; Organophosphonates; Phosphotransferases; Rabbits; Swine | 1973 |
Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro.
Topics: Calcium; Chondroitin; Crystallization; Crystallography; Diphosphates; Heparin; Magnesium; Methylene Blue; Molecular Conformation; Organophosphonates; Oxalates; Sulfuric Acids; Urea | 1973 |
Yeast inorganic pyrophosphatase. II. Magnetic resonance and steady-state kinetic studies of metal ion and pyrophosphate analog binding.
Topics: Binding Sites; Binding, Competitive; Calcium; Cations, Divalent; Diphosphates; Electron Spin Resonance Spectroscopy; Gadolinium; Kinetics; Magnesium; Magnetic Resonance Spectroscopy; Manganese; Methanol; Organophosphonates; Osmolar Concentration; Pyrophosphatases; Saccharomyces cerevisiae; Structure-Activity Relationship; Temperature; Zinc | 1973 |
Kinetic effects of inorganic pyrophosphate analogs on several inorganic pyrophosphate hydrolyzing enzymes.
Topics: Alkaline Phosphatase; Animals; Binding, Competitive; Cattle; Diphosphates; Esters; Imides; Intestines; Kinetics; Microsomes, Liver; Nitrobenzenes; Organophosphonates; Organophosphorus Compounds; Phosphates; Phosphoric Acids; Pyrophosphatases; Rats; Saccharomyces cerevisiae; Species Specificity; Structure-Activity Relationship; Zea mays | 1973 |
Proceedings: Comparison of 99Tc-labelled polyphosphate, pyrophosphate and ethane hydroxydiphosphonate in patients with skeletal metastases.
Topics: Alkanes; Bone Neoplasms; Diphosphates; Humans; Neoplasm Metastasis; Organophosphonates; Phosphates; Radionuclide Imaging; Technetium | 1974 |
[Comparative animal experiments concerning the distribution of 99mTc-pyrophosphate, 99mTc-diphosphonate and 85Sr (author's transl)].
Topics: Animals; Bone and Bones; Chlorides; Diphosphates; Injections, Intravenous; Muscles; Organophosphonates; Rabbits; Radionuclide Imaging; Strontium; Strontium Radioisotopes; Technetium; Thyroid Gland | 1974 |
Stimulation of alkaline phosphatase by analogs of inorganic pyrophosphate.
Topics: Alkaline Phosphatase; Animals; Cattle; Chelating Agents; Diphosphates; Edetic Acid; Escherichia coli; Imides; Intestines; Isomerism; Kinetics; Macromolecular Substances; Nitrobenzenes; Organophosphonates; Organophosphorus Compounds; Phosphates; Phosphoric Acids; Phosphorous Acids; Structure-Activity Relationship | 1974 |
[Administration of a diphosphonate in urinary calculi prevention].
Topics: Adult; Calcium; Depression, Chemical; Diphosphates; Humans; Middle Aged; Organophosphonates; Oxalates; Phosphates; Time Factors; Urinary Calculi | 1974 |
Energy-linked reactions in photosynthetic bacteria. IX. Pi-PPi exchange in Rhodospirillum rubrum.
Topics: Antimycin A; Bacterial Chromatophores; Chromatography, Ion Exchange; Chromatography, Thin Layer; Cyanides; Darkness; Diphosphates; Fluorides; Kinetics; Light; Magnesium; Oligomycins; Organophosphonates; Phenylhydrazines; Phosphates; Phosphorus Radioisotopes; Quinacrine; Rhodospirillum rubrum; Time Factors; Uncoupling Agents | 1974 |
[Proceedings: The effect of diphosphonate on crystal formation of calcium phosphates in vitro].
Topics: Animals; Calcium Phosphates; Crystallization; Diphosphates; In Vitro Techniques; Organophosphonates; Rats; Tail; Tendons | 1974 |
Pyrophosphate-dependent phosphofructokinase of Entamoeba histolytica: molecular cloning, recombinant expression and inhibition by pyrophosphate analogues.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cloning, Molecular; Diphosphates; DNA Primers; DNA, Complementary; Entamoeba histolytica; Escherichia coli; Kinetics; Molecular Sequence Data; Organophosphonates; Phosphotransferases; Propionibacterium; Recombinant Proteins; Sequence Homology, Amino Acid | 1996 |
Comparison of antiviral compounds against human herpesvirus 6 and 7.
Topics: Antiviral Agents; Cells, Cultured; Diphosphates; Guanine; Herpesvirus 6, Human; Herpesvirus 7, Human; Humans; Leukocytes, Mononuclear; Organophosphonates; Ribonucleosides; Virus Replication | 1998 |
Design, synthesis, and anticancer activity of phosphonic acid diphosphate derivative of adenine-containing butenolide and its water-soluble derivatives of paclitaxel with high antitumor activity.
Topics: 4-Butyrolactone; Adenine; Animals; Antineoplastic Agents; Cell Division; Cell Line, Tumor; Cell Nucleus; Diphosphates; Drug Design; Drug Screening Assays, Antitumor; Furans; Humans; Microtubules; Organophosphonates; Paclitaxel; Prodrugs; Ribonucleoside Diphosphate Reductase; Solubility; Structure-Activity Relationship | 2003 |
The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon.
Topics: Adenine; Animals; Diphosphates; DNA; DNA-Directed DNA Polymerase; Exonucleases; Kinetics; Molecular Structure; Oligonucleotides; Organophosphonates; Organophosphorus Compounds; Proliferating Cell Nuclear Antigen; Rats; Substrate Specificity; Templates, Genetic | 2004 |
Mechanism of inhibition of vaccinia virus DNA polymerase by cidofovir diphosphate.
Topics: Antiviral Agents; Cidofovir; Cytosine; Diphosphates; DNA Primers; DNA-Directed DNA Polymerase; Nucleic Acid Synthesis Inhibitors; Organophosphonates; Substrate Specificity | 2005 |
Simultaneous determination of phosphonate, phosphate, and diphosphate by capillary electrophoresis using in-capillary complexation with Mo(VI).
Topics: Acetonitriles; Diphosphates; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Malonates; Molybdenum; Organophosphonates; Phosphates; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Time Factors | 2007 |
Chelation of vanadium(V) by difluoromethylene bisphosphonate, a structural analogue of pyrophosphate.
Topics: Anions; Chelating Agents; Chemistry; Crystallography, X-Ray; Diphosphates; Diphosphonates; Electrolytes; Hydrogen; Hydrogen-Ion Concentration; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Organophosphonates; Sodium; Vanadium | 2007 |
Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.
Topics: Adenine; Anti-HIV Agents; Diphosphates; Guanosine; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
P1,P2-diimidazolyl derivatives of pyrophosphate and bis-phosphonates--synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs.
Topics: Cyclization; Dinucleoside Phosphates; Diphosphates; Imidazoles; Molecular Structure; Organophosphonates | 2011 |
Tenofovir-induced Fanconi syndrome and osteomalacia in two HIV-infected patients: role of intracellular tenofovir diphosphate levels and review of the literature.
Topics: Adenine; Adult; Anti-HIV Agents; Diphosphates; Fanconi Syndrome; HIV Infections; Humans; Male; Middle Aged; Organophosphonates; Osteomalacia; Radionuclide Imaging; Tenofovir; Whole Body Imaging | 2011 |
Determination of nucleoside analog mono-, di-, and tri-phosphates in cellular matrix by solid phase extraction and ultra-sensitive LC-MS/MS detection.
Topics: Adenine; Anion Exchange Resins; Antiviral Agents; Calibration; Chromatography, Liquid; Deoxycytidine; Diphosphates; Emtricitabine; Humans; Lamivudine; Leukocytes, Mononuclear; Nucleosides; Organophosphonates; Phosphates; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Tenofovir; Zidovudine | 2011 |
Tenofovir diphosphate and emtricitabine triphosphate concentrations in blood cells compared with isolated peripheral blood mononuclear cells: a new measure of antiretroviral adherence?
Topics: Adenine; Adult; Anti-HIV Agents; Blood Cells; Deoxycytidine; Diphosphates; Emtricitabine; Female; HIV Infections; Humans; Leukocytes, Mononuclear; Male; Medication Adherence; Middle Aged; Organophosphonates; Polyphosphates; Tenofovir | 2013 |
First Crystal Structures of Mycobacterium tuberculosis 6-Oxopurine Phosphoribosyltransferase: Complexes with GMP and Pyrophosphate and with Acyclic Nucleoside Phosphonates Whose Prodrugs Have Antituberculosis Activity.
Topics: Amino Acid Sequence; Antineoplastic Agents; Antitubercular Agents; Catalytic Domain; Cell Proliferation; Crystallography, X-Ray; Diphosphates; Enzyme Inhibitors; Guanosine Monophosphate; Humans; Hypoxanthine Phosphoribosyltransferase; Lung Neoplasms; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mycobacterium tuberculosis; Organophosphonates; Prodrugs; Protein Conformation; Sequence Homology, Amino Acid; Structure-Activity Relationship; Tuberculosis; Tumor Cells, Cultured | 2015 |