Compounds > organophosphonates
Page last updated: 2024-09-05

organophosphonates and phosphotyrosine

organophosphonates has been researched along with phosphotyrosine in 12 studies

Compound Research Comparison

Studies
(organophosphonates)		Trials
(organophosphonates)		Recent Studies (post-2010)
(organophosphonates)		Studies
(phosphotyrosine)		Trials
(phosphotyrosine)		Recent Studies (post-2010) (phosphotyrosine)
9,9688803,5966,4754751

Research

Studies (12)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (33.33)18.2507
2000's7 (58.33)29.6817
2010's1 (8.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Appella, E; Roller, PP; Sakaguchi, K1
Barford, D; Burke, TR; Chen, L; Jia, Z; Wang, S; Yan, X; Ye, B; Zhang, ZY1
Burke, TR; Cao, T; Kelley, J; King, CR; Milne, GW; Voigt, JH; Yao, ZJ1
Barford, D; Burke, TR; Groves, MR; Roller, PP; Yao, ZJ1
Bartlett, C; Bohacek, RS; Dalgarno, DC; Eyermann, CJ; Guan, W; Hatada, M; Johnson, D; Kawahata, N; Lu, X; Luke, GP; Merry, T; Sawyer, TK; Shakespeare, WC; Smith, J; Sundaramoorthi, R; Violette, S; Wang, Y; Yang, MG1
Dinaut, AN; Hum, G; Jia, Z; Kennedy, B; Payette, P; Ramachandran, C; Taylor, SD; Waddleton, D; Wang, Q; Ye, Q1
Cole, PA; Lu, W; Shen, K1
Liu, G1
Czyryca, PG; Hengge, AC; Iyer, S; Younker, JM1
Bindu, LK; Burke, TR; Fisher, RJ; Kang, SU; Karki, RG; Nicklaus, MC; Oishi, S; Wang, X; Worthy, KM1
Beselman, A; Boresch, S; Leitgeb, M; MacKerell, AD1
Accorsi, M; Rademann, J; Wagner, S1

Reviews

2 review(s) available for organophosphonates and phosphotyrosine

ArticleYear
Chemical synthesis and applications of phosphopeptides.
    Genetic engineering, 1996, Volume: 18

    Topics: Amino Acid Sequence; Animals; Antibodies; Antigens; Models, Molecular; Molecular Sequence Data; Organophosphonates; Phosphopeptides; Phosphoprotein Phosphatases; Phosphorylation; Phosphoserine; Phosphothreonine; Phosphotyrosine; Protein Conformation; Protein Structure, Secondary; src Homology Domains; Substrate Specificity; Thermodynamics

1996
Protein tyrosine phosphatase 1B inhibition: opportunities and challenges.
    Current medicinal chemistry, 2003, Volume: 10, Issue:15

    Topics: Acetates; Animals; Benzoates; Enzyme Inhibitors; Humans; Hydroquinones; Insulin Resistance; Molecular Mimicry; Oligonucleotides, Antisense; Organophosphonates; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Salicylates; Structure-Activity Relationship

2003

Other Studies

10 other study(ies) available for organophosphonates and phosphotyrosine

ArticleYear
Small molecule interactions with protein-tyrosine phosphatase PTP1B and their use in inhibitor design.
    Biochemistry, 1996, Dec-17, Volume: 35, Issue:50

    Topics: Binding Sites; Calorimetry; Computer Simulation; Crystallography, X-Ray; Cysteine; Drug Design; Enzyme Inhibitors; Kinetics; Models, Molecular; Naphthalenes; Organophosphonates; Phosphotyrosine; Point Mutation; Protein Conformation; Protein Structure, Secondary; Protein Tyrosine Phosphatases; Recombinant Proteins; Serine

1996
Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands.
    Journal of medicinal chemistry, 1999, Jan-14, Volume: 42, Issue:1

    Topics: Adaptor Proteins, Signal Transducing; Asparagine; Female; GRB2 Adaptor Protein; Humans; Ligands; Models, Molecular; Molecular Mimicry; Organophosphonates; Phenylalanine; Phosphotyrosine; Protein Binding; Proteins; Receptor, ErbB-2; Recombinant Proteins; src Homology Domains; Structure-Activity Relationship; Surface Plasmon Resonance; Tumor Cells, Cultured

1999
Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics.
    Biochemistry, 1998, Dec-22, Volume: 37, Issue:51

    Topics: Binding Sites; Computer Simulation; Crystallography, X-Ray; Enzyme Inhibitors; Humans; Macromolecular Substances; Models, Molecular; Molecular Mimicry; Organophosphonates; Organophosphorus Compounds; Peptides, Cyclic; Phosphotyrosine; Protein Tyrosine Phosphatases; Structure-Activity Relationship; Tyrosine

1998
A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain.
    Bioorganic & medicinal chemistry letters, 2001, Sep-03, Volume: 11, Issue:17

    Topics: Animals; Benzamides; Binding Sites; Bone Resorption; Crystallography, X-Ray; Dentin; Drug Design; Enzyme Inhibitors; Magnetic Resonance Spectroscopy; Molecular Mimicry; Mutation; Organophosphonates; Osteoclasts; Phosphotyrosine; Proto-Oncogene Proteins pp60(c-src); Rabbits; src Homology Domains; Structure-Activity Relationship

2001
Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.
    Journal of medicinal chemistry, 2001, Dec-20, Volume: 44, Issue:26

    Topics: Binding Sites; Crystallography, X-Ray; Enzyme Inhibitors; Models, Molecular; Molecular Mimicry; Organophosphonates; Phosphotyrosine; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Structure-Activity Relationship

2001
Chemical dissection of the effects of tyrosine phosphorylation of SHP-2.
    Biochemistry, 2003, May-13, Volume: 42, Issue:18

    Topics: Amino Acid Sequence; Humans; Intracellular Signaling Peptides and Proteins; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphonates; Peptide Fragments; Phosphorylation; Phosphotyrosine; Point Mutation; Protein Binding; Protein Conformation; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; SH2 Domain-Containing Protein Tyrosine Phosphatases; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; src Homology Domains; Tyrosine

2003
A nonhydrolyzable analogue of phosphotyrosine, and related aryloxymethano- and aryloxyethano-phosphonic acids as motifs for inhibition of phosphatases.
    Bioorganic & medicinal chemistry letters, 2004, Dec-06, Volume: 14, Issue:23

    Topics: Organophosphonates; Phosphoprotein Phosphatases; Phosphotyrosine; Protease Inhibitors

2004
Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics.
    Journal of medicinal chemistry, 2005, Feb-10, Volume: 48, Issue:3

    Topics: Adaptor Proteins, Signal Transducing; Binding Sites; Cyclization; GRB2 Adaptor Protein; Models, Molecular; Molecular Conformation; Molecular Mimicry; Organophosphonates; Phenylalanine; Phosphopeptides; Phosphotyrosine; Protein Binding; src Homology Domains; Stereoisomerism; Structure-Activity Relationship; Tetrahydronaphthalenes

2005
Unexpected relative aqueous solubilities of a phosphotyrosine analogue and two phosphonate derivatives.
    Journal of the American Chemical Society, 2005, Apr-06, Volume: 127, Issue:13

    Topics: Computer Simulation; Models, Molecular; Organophosphonates; Peptides; Phenylalanine; Phosphotyrosine; Solubility; src Homology Domains; Thermodynamics; Water

2005
Benzyl Mono-P-Fluorophosphonate and Benzyl Penta-P-Fluorophosphate Anions Are Physiologically Stable Phosphotyrosine Mimetics and Inhibitors of Protein Tyrosine Phosphatases.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2017, Nov-02, Volume: 23, Issue:61

    Topics: Anions; Binding Sites; Drug Design; Enzyme Inhibitors; Fluorides; Humans; Hydrogen Bonding; Kinetics; Magnetic Resonance Spectroscopy; Molecular Docking Simulation; Organophosphonates; Phosphates; Phosphotyrosine; Protein Structure, Tertiary; Protein Tyrosine Phosphatase, Non-Receptor Type 1

2017