Compounds > organophosphonates
Page last updated: 2024-09-05

organophosphonates and oligonucleotides

organophosphonates has been researched along with oligonucleotides in 78 studies

Compound Research Comparison

Studies
(organophosphonates)		Trials
(organophosphonates)		Recent Studies (post-2010)
(organophosphonates)		Studies
(oligonucleotides)		Trials
(oligonucleotides)		Recent Studies (post-2010) (oligonucleotides)
9,9688803,59623,1282457,331

Research

Studies (78)

TimeframeStudies, this research(%)All Research%
pre-19909 (11.54)18.7374
1990's14 (17.95)18.2507
2000's36 (46.15)29.6817
2010's15 (19.23)24.3611
2020's4 (5.13)2.80

Authors

AuthorsStudies
Agarwal, KL; Riftina, F1
Krecmerova, M; Röling, A; Rosemeyer, H; Seela, F1
Bashirova, VZ; Sergeyeva, ZA; Venyaminova, AG1
Fedoryak, DM; Lyapina, TV1
Efimov, VA; Pashkova, IN; Polushin, NN1
Alings, C; Blöcker, H; Frank, R; Heikens, W; Heinemann, U; Morr, M; Rudolph, LN1
Rösch, R; Seliger, H1
Dubeĭ, IIa; Efimov, VA1
Aurelian, L; Fishelevich, R; Kulka, M; Meade, K; Miller, P; Smith, CC; Ts'o, PO1
Chang, EH; Shinozuka, K; Strekowska, A; Wilson, WD; Yu, Z; Zon, G1
Davies, LC; Harrap, KR; Orr, RM; Powles, RL; Stock, JA; Taylor, GA1
Cook, RM; Sinha, ND1
Agarwal, K; Callahan, L; Duchamp, D; Han, FS; Kézdy, FJ; Watt, W1
Fakunding, JL; Hershey, JW1
Jayaraman, K; McParland, K; Miller, P; Ts'o, PO1
Chacko, KK; Lindner, K; Miller, PS; Saenger, W1
Chen, MS; Cherrington, JM; Fuller, MD; Mulato, AS1
Aguilar, L; Blumenfeld, M; Dautry-Varsat, A; Hémar, A1
Bartlett, MG; Griffey, RH; Manalili, S; McCloskey, JA1
Buryakova, AA; Chakhmakhcheva, OG; Choob, MV; Efimov, VA; Kalinkina, AL1
Reese, CB; Song, Q1
Barvík, I; Bok, J; Stĕpánek, J1
Endová, M; Liboska, R; Pressová, M; Rosenberg, I; Toĉík, Z1
Padiya, KJ; Salunkhe, MM1
An, H; Cook, PD; Maier, MA; Manoharan, M; Ross, BS; Wang, T1
Boom, JH; Gómez-Pinto, I; González, C; Marel, GA; Meeuwenoord, NJ; Monaco, V; Orozco, M; Soliva, R1
Anjaneyulu, PS; Boehringer, M; Caruthers, MH; Curley, JF; Hsu, M; Liao, X; Piccirilli, JA1
Abbas, S; Bertram, RD; Hayes, CJ1
Jankowski, S; Lesnikowski, ZJ; Olejniczak, AB1
Bertram, RD; Hayes, CJ; Soultanas, P1
Kraszewski, A; Stawinski, J1
Schultz, C1
Mohe, NU; Padiya, KJ; Salunkhe, MM1
Budĕsínský, M; Králíková, S; Masojídková, M; Rosenberg, I1
Birkus, G; Holy, A; Otmar, M; Rejman, D; Rosenberg, I; Votruba, I1
Bryant-Friedrich, AC1
Capaldi, DC; Carty, RL; Decottignies, SD; Gaus, HJ; Krotz, AH; McArdle, JV; Moore, MN; Ravikumar, VT; Scozzari, AN; Turney, BJ1
Stawinski, J; Strömberg, R1
Dediulescu, DF; Dediulescu, L1
Heinonen, P; Mohe, N; Sanghvi, YS; Strömberg, R1
Jankowska, J; Kraszewski, A; Sobkowski, M; Stawinski, J1
Ferreira, F; Meyer, A; Morvan, F; Vasseur, JJ1
Dahl, BM; Dahl, O; Henriksen, U1
Caruthers, MH; Higson, AP; McCuen, HB; Noé, MS; Sierzchala, AB1
Barvík, I; Budesínský, M; Rosenberg, I; Tocík, Z1
Chacun, H; Couvreur, P; Hillaireau, H; Janin, J; Le Doan, T1
Bryant-Friedrich, AC; Hitt, AL; Lahoud, GA1
Iyer, PC; Jerina, DM; Sayer, JM; Yagi, H1
Emmerechts, G; Herdewijn, P; Holý, A; Krecmerová, M; Renders, M; Rozenski, J1
Higashida, R; Kawanaka, T; Oka, N; Wada, T2
Komiyama, M; Lönnberg, T; Suzuki, Y2
Johnson, DC; Widlanski, TS1
Kawanaka, T; Shimizu, M; Shintani, N; Wada, T1
Kósíová, I; Rosenberg, I1
Budesínský, M; Králíková, S; Petrová, M; Rosenberg, I1
Herdewijn, P; Holý, A; Krecmerová, M; Lievrouw, R; Renders, M1
Iglina, AA; Meschaninova, MI; Venyaminova, AG1
Aiba, Y; Hamano, Y; Komiyama, M; Lönnberg, T; Miyajima, Y; Sumaoka, J1
Aiba, Y; Komiyama, M; Lönnberg, T1
Alvira, M; Murtola, M; Stenberg, A; Steunenberg, P; Strömberg, R; Wenska, M1
Bräse, S; Griesser, H; Richert, C; Schilling, CI; Singh, A; Tolev, M1
Atherton, J; Page, MI; Powles, N1
Baik, SK; Chae, HB; Hong, SP; Kim, CW; Kim, JH; Kim, MY; Kim, YS; Lee, CD; Lee, JI; Lee, JW; Lee, MS; Park, CK; Park, SH; Seo, YS; Um, SH; Yim, HJ; Yoon, EL1
Chen, H; Chen, J; Jiang, L; Li, D; Lin, J; Ou, Q; Su, M; Wang, W; Yang, B; Zeng, Y1
Kraszewski, A; Sobkowski, M; Stawinski, J1
Caruthers, MH; Monfregola, L; Paul, S; Roy, S; Shang, S; Shoemaker, R1
Hocková, D; Ménová, P; Novák, P; Páv, O; Pohl, R; Rosenberg, I; Rosenbergová, Š1
Caruthers, MH; Monfregola, L1
Barvík, I; Buděšínský, M; Liboska, R; Novák, P; Páv, O; Petrová, M; Rosenberg, I; Rosenbergová, Š; Šimák, O1
Kostov, O; Páv, O; Rosenberg, I1
Damha, MJ; Vlaho, D1
Froeyen, M; Groaz, E; Herdewijn, P; Jaziri, F; Leonczak, P; Luo, M; Marlière, P; Pezo, V; Rozenski, J; Schepers, G1
Baran, PS; Eastgate, MD; Knouse, KW; Padial, NM; Rivas-Bascón, N; Schmidt, MA; Vantourout, JC; Xu, D; Zheng, B1
Caruthers, MH; Kumar, P1
Alterman, JF; Aronin, N; Caiazzi, J; Conroy, F; Davis, SM; DiFiglia, M; Echeverria, D; Hassler, MR; Hildebrand, S; Khvorova, A; Miller, R; Pfister, EL; Roux, L; Sapp, E; Yamada, K1
Cheatham, TE; Freestone, GC; Galindo-Murillo, R; Gaus, H; Hanessian, S; Lugato, B; Migawa, MT; Rajasekaran, T; Rico, L; Salinas, JC; Seth, PP; Swayze, EE1

Reviews

5 review(s) available for organophosphonates and oligonucleotides

ArticleYear
How to get the most out of two phosphorus chemistries. Studies on H-phosphonates.
    Accounts of chemical research, 2002, Volume: 35, Issue:11

    Topics: Oligonucleotides; Organophosphonates; Oxidation-Reduction; Phosphites

2002
Prodrugs of biologically active phosphate esters.
    Bioorganic & medicinal chemistry, 2003, Mar-20, Volume: 11, Issue:6

    Topics: Animals; Esters; Humans; Indicators and Reagents; Inositol Phosphates; Oligonucleotides; Organophosphonates; Phosphates; Phosphatidylinositols; Phosphinic Acids; Prodrugs

2003
[Antiherpetic therapy].
    Oftalmologia (Bucharest, Romania : 1990), 2005, Volume: 49, Issue:1

    Topics: 2-Aminopurine; Acyclovir; Antiviral Agents; Bromodeoxyuridine; Cidofovir; Cytosine; Drug Combinations; Famciclovir; Foscarnet; Ganciclovir; Humans; Idoxuridine; Keratitis, Herpetic; Oligonucleotides; Ophthalmic Solutions; Organophosphonates; Treatment Outcome; Valacyclovir; Valine; Vidarabine

2005
Overview of the synthesis of nucleoside phosphates and polyphosphates.
    Current protocols in nucleic acid chemistry, 2004, Volume: Chapter 13

    Topics: Amides; Anhydrides; Catalysis; Models, Biological; Nucleosides; Nucleotides; Oligonucleotides; Organophosphonates; Phosphates; Phosphoadenosine Phosphosulfate; Phosphoric Acids; Phosphorus; Phosphorylation; Polyphosphates

2004
Recent advances in H-phosphonate chemistry. Part 1. H-phosphonate esters: synthesis and basic reactions.
    Topics in current chemistry, 2015, Volume: 361

    Topics: Esters; Nucleosides; Oligonucleotides; Organophosphonates; Organophosphorus Compounds; Phosphorus; Stereoisomerism

2015

Trials

1 trial(s) available for organophosphonates and oligonucleotides

ArticleYear
Adding adefovir vs. switching to entecavir for lamivudine-resistant chronic hepatitis B (ACE study): a 2-year follow-up randomized controlled trial.
    Liver international : official journal of the International Association for the Study of the Liver, 2013, Volume: 33, Issue:2

    Topics: Adenine; Adult; Analysis of Variance; Antiviral Agents; DNA, Viral; Drug Resistance, Viral; Female; Follow-Up Studies; Guanine; Hepatitis B; Hepatitis B, Chronic; Humans; Immunoassay; Lamivudine; Male; Middle Aged; Oligonucleotides; Organophosphonates; Prospective Studies; Republic of Korea; Reverse Transcriptase Inhibitors; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Treatment Outcome

2013

Other Studies

72 other study(ies) available for organophosphonates and oligonucleotides

ArticleYear
Synthesis and enzymatic properties of deoxyribooligonucleotides containing methyl and phenylphosphonate linkages.
    Nucleic acids research, 1979, Jul-11, Volume: 6, Issue:9

    Topics: Esters; Kinetics; Methods; Methylation; Oligodeoxyribonucleotides; Oligonucleotides; Organophosphonates; Phosphoric Diester Hydrolases; Structure-Activity Relationship

1979
Solid-phase synthesis of oligo(2'-deoxyxylonucleotides) and PCR amplification of base-modified DNA fragments.
    Nucleic acids symposium series, 1991, Issue:24

    Topics: Adenosine; Base Sequence; DNA; DNA Restriction Enzymes; DNA-Directed DNA Polymerase; Molecular Sequence Data; Molecular Structure; Oligonucleotides; Organophosphonates; Polymerase Chain Reaction; Restriction Mapping; Substrate Specificity; Taq Polymerase; Thymidine; Xylose

1991
A new method for introduction of steroid residues in mono- and oligonucleotides via H-phosphonates of hydroxysterols.
    Nucleic acids symposium series, 1991, Issue:24

    Topics: Cholesterol; Indicators and Reagents; Nucleotides; Oligonucleotides; Organophosphonates; Testosterone

1991
H-phosphonate oligonucleotide synthesis in solution.
    Nucleic acids symposium series, 1991, Issue:24

    Topics: Base Sequence; Oligodeoxyribonucleotides; Oligonucleotides; Organophosphonates; Solutions

1991
Rapid deprotection procedures for synthetic oligonucleotides.
    Nucleic acids symposium series, 1991, Issue:24

    Topics: Chemistry; Indicators and Reagents; Oligonucleotides; Organophosphonates; Phosphates

1991
Effect of a single 3'-methylene phosphonate linkage on the conformation of an A-DNA octamer double helix.
    Nucleic acids research, 1991, Feb-11, Volume: 19, Issue:3

    Topics: Crystallography; DNA; Models, Molecular; Nucleic Acid Conformation; Oligonucleotides; Organophosphonates; Structure-Activity Relationship; Water

1991
Simultaneous synthesis of multiple oligonucleotides using nucleoside-H-phosphonate intermediates.
    DNA and cell biology, 1990, Volume: 9, Issue:9

    Topics: Base Sequence; Chromatography, High Pressure Liquid; Genetic Techniques; Molecular Sequence Data; Nucleic Acid Hybridization; Oligonucleotide Probes; Oligonucleotides; Organophosphonates

1990
[Modification of H-phosphonate method of oligonucleotide synthesis on polymer support].
    Bioorganicheskaia khimiia, 1990, Volume: 16, Issue:2

    Topics: Base Sequence; Catalysis; Chemical Phenomena; Chemistry; Methods; Molecular Sequence Data; Oligonucleotides; Organophosphonates; Phosphorylation; Quinolines

1990
Site specificity of the inhibitory effects of oligo(nucleoside methylphosphonate)s complementary to the acceptor splice junction of herpes simplex virus type 1 immediate early mRNA 4.
    Proceedings of the National Academy of Sciences of the United States of America, 1989, Volume: 86, Issue:18

    Topics: Animals; Base Sequence; Cell Line; Exons; Genes, Viral; Introns; Molecular Sequence Data; Oligonucleotides; Organophosphonates; Protein Biosynthesis; RNA Splicing; RNA, Messenger; RNA, Viral; Simplexvirus; Ultraviolet Rays; Vero Cells

1989
Comparative inhibition of ras p21 protein synthesis with phosphorus-modified antisense oligonucleotides.
    Anti-cancer drug design, 1989, Volume: 4, Issue:3

    Topics: Animals; Gene Expression Regulation; In Vitro Techniques; Mice; Mice, Inbred BALB C; Nucleic Acid Hybridization; Oligonucleotides; Oligonucleotides, Antisense; Oncogene Protein p21(ras); Organophosphonates; Plasmids; Protein Biosynthesis; Structure-Activity Relationship; Temperature; Transcription, Genetic

1989
Inhibition of human leukaemic thymidylate kinase and L1210 ribonucleotide reductase by dinucleotides of adenosine and thymidine and their phosphonate analogues.
    Biochemical pharmacology, 1988, Feb-15, Volume: 37, Issue:4

    Topics: Adenosine; Animals; Dose-Response Relationship, Drug; Humans; Kinetics; Leukemia L1210; Leukemia, Myeloid, Acute; Nucleoside-Phosphate Kinase; Oligonucleotides; Organophosphonates; Phosphotransferases; Ribonucleoside Diphosphate Reductase; Ribonucleotide Reductases; Thymidine

1988
The preparation and application of functionalised synthetic oligonucleotides: III. Use of H-phosphonate derivatives of protected amino-hexanol and mercapto-propanol or -hexanol.
    Nucleic acids research, 1988, Mar-25, Volume: 16, Issue:6

    Topics: 1-Propanol; Amino Alcohols; Biotin; Chemical Phenomena; Chemistry; Fluorescent Dyes; Hexanols; Oligonucleotides; Organophosphonates; Sulfhydryl Compounds

1988
B- to Z-DNA transition probed by oligonucleotides containing methylphosphonates.
    Proceedings of the National Academy of Sciences of the United States of America, 1986, Volume: 83, Issue:6

    Topics: Base Composition; Chemical Phenomena; Chemistry, Physical; Circular Dichroism; Crystallization; DNA; Kinetics; Models, Molecular; Nucleic Acid Conformation; Oligodeoxyribonucleotides; Oligonucleotides; Organophosphonates; Osmolar Concentration; Solutions

1986
The interaction of radioactive initiation factor IF-2 with ribosomes during initiation of protein synthesis.
    The Journal of biological chemistry, 1973, Jun-25, Volume: 248, Issue:12

    Topics: Animals; Bacterial Proteins; Drug Stability; Escherichia coli; Formates; Glutaral; Guanine; Guanosine Triphosphate; Methionine; Models, Chemical; Muscles; Oligonucleotides; Organophosphonates; Peptide Initiation Factors; Phosphorus Isotopes; Protein Binding; Protein Kinases; Rabbits; Ribosomes; RNA, Messenger; RNA, Transfer

1973
Selective inhibition of Escherichia coli protein synthesis and growth by nonionic oligonucleotides complementary to the 3' end of 16S rRNA.
    Proceedings of the National Academy of Sciences of the United States of America, 1981, Volume: 78, Issue:3

    Topics: Animals; Bacterial Proteins; Base Sequence; Cell-Free System; Escherichia coli; Oligodeoxyribonucleotides; Oligonucleotides; Organophosphonates; Protein Biosynthesis; Rabbits; Reticulocytes; RNA; RNA, Messenger; Structure-Activity Relationship

1981
Molecular structure of deoxyadenylyl-3'-methylphosphonate-5'-thymidine dihydrate, (d-ApT x 2H2O), a dinucleoside monophosphate with neutral phosphodiester backbone. An X-ray crystal study.
    Nucleic acids research, 1983, May-11, Volume: 11, Issue:9

    Topics: Crystallography; Dinucleoside Phosphates; Oligonucleotides; Organophosphonates; Structure-Activity Relationship; X-Ray Diffraction

1983
Novel mutation (K70E) in human immunodeficiency virus type 1 reverse transcriptase confers decreased susceptibility to 9-[2-(phosphonomethoxy)ethyl]adenine in vitro.
    Antimicrobial agents and chemotherapy, 1996, Volume: 40, Issue:9

    Topics: Adenine; Antiviral Agents; Genotype; HIV Reverse Transcriptase; HIV-1; Humans; Kinetics; Oligonucleotides; Organophosphonates; Reverse Transcriptase Inhibitors; Virus Replication

1996
Hairpin, dumbbell, and single-stranded phosphodiester oligonucleotides exhibit identical uptake in T lymphocyte cell lines.
    Antisense & nucleic acid drug development, 1996,Fall, Volume: 6, Issue:3

    Topics: DNA, Single-Stranded; Esters; Exocytosis; Flow Cytometry; Fluorescein-5-isothiocyanate; Humans; Jurkat Cells; Microscopy, Confocal; Nucleic Acid Conformation; Oligonucleotides; Organophosphonates; T-Lymphocytes

1996
The effect of backbone charge on the collision-induced dissociation of oligonucleotides.
    Journal of mass spectrometry : JMS, 1996, Volume: 31, Issue:11

    Topics: Electrochemistry; Mass Spectrometry; Oligonucleotides; Organophosphonates; Sequence Analysis, DNA

1996
Synthesis and evaluation of some properties of chimeric oligomers containing PNA and phosphono-PNA residues.
    Nucleic acids research, 1998, Jan-15, Volume: 26, Issue:2

    Topics: Chemical Phenomena; Chemistry, Physical; Dimerization; DNA, Complementary; Drug Stability; Glycine; Hot Temperature; Nucleic Acid Hybridization; Nucleic Acids; Nylons; Oligonucleotides; Organophosphonates; Peptides; Phosphodiesterase I; Phosphoric Diester Hydrolases; RNA, Complementary; Single-Strand Specific DNA and RNA Endonucleases; Solubility; Ultraviolet Rays

1998
A new approach to oligonucleotide synthesis in solution.
    Nucleic acids symposium series, 1997, Issue:37

    Topics: Indicators and Reagents; Oligonucleotides; Organophosphonates; Solutions; Sulfur; Thionucleotides

1997
Molecular dynamics simulations of nucleic acids: A). Molecular dynamics simulations of the oligonucleotide with the modified phosphate/phosphonate internucleotide linkage.
    General physiology and biophysics, 1998, Volume: 17 Suppl 1

    Topics: Base Sequence; Biophysical Phenomena; Biophysics; DNA; Nucleic Acid Conformation; Nucleic Acids; Oligodeoxyribonucleotides; Oligonucleotides; Organophosphonates; Phosphates; Thermodynamics

1998
UV spectroscopy study on complexes of phosphonate ApA analogs with poly(U): promising step in prediction of oligonucleotide analog properties?
    Bioorganic & medicinal chemistry letters, 1998, May-19, Volume: 8, Issue:10

    Topics: Adenine; Dinucleoside Phosphates; Kinetics; Molecular Structure; Nucleic Acid Conformation; Oligonucleotides; Organophosphonates; Poly U; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Thermodynamics

1998
Large scale, liquid phase oligonucleotide synthesis by alkyl H-phosphonate approach.
    Bioorganic & medicinal chemistry, 2000, Volume: 8, Issue:2

    Topics: Base Sequence; Magnetic Resonance Spectroscopy; Oligonucleotides; Organophosphonates; Oxidation-Reduction

2000
Synthesis of novel 3'-C-methylene thymidine and 5-methyluridine/cytidine H-phosphonates and phosphonamidites for new backbone modification of oligonucleotides.
    The Journal of organic chemistry, 2001, Apr-20, Volume: 66, Issue:8

    Topics: Anti-Infective Agents; Antineoplastic Agents; Cytidine; Oligonucleotides; Oligonucleotides, Antisense; Organophosphonates; Thymidine; Uridine

2001
Solution structure of a DNA duplex with a chiral alkyl phosphonate moiety.
    Nucleic acids research, 2001, Jul-15, Volume: 29, Issue:14

    Topics: Base Sequence; DNA; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Nucleic Acid Conformation; Nucleic Acid Denaturation; Oligonucleotides; Organophosphonates

2001
The tetrahymena ribozyme cleaves a 5'-methylene phosphonate monoester approximately 10(2)-fold faster than a normal phosphate diester: implications for enzyme catalysis of phosphoryl transfer reactions.
    Biochemistry, 2001, Sep-18, Volume: 40, Issue:37

    Topics: Animals; Catalysis; Esters; Kinetics; Models, Chemical; Molecular Probes; Oligonucleotides; Organophosphonates; RNA, Catalytic; Substrate Specificity; Tetrahymena thermophila; Thermodynamics

2001
Commercially available 5'-DMT phosphoramidites as reagents for the synthesis of vinylphosphonate-linked oligonucleic acids.
    Organic letters, 2001, Oct-18, Volume: 3, Issue:21

    Topics: Amides; Molecular Structure; Oligonucleotides; Organophosphonates; Organophosphorus Compounds; Phosphoric Acids; Vinyl Compounds

2001
P-chiral oligonucleotides. 2D Roesy NMR assignment of absolute configuration at phosphorus and conformational analysis of 5'-O-monomethoxytrityl-(2'-O-deoxyribonucleoside) 3'-O-[O-(4-nitrophenyl)]methanephosphonates.
    Nucleosides, nucleotides & nucleic acids, 2002, Volume: 21, Issue:2

    Topics: Magnetic Resonance Spectroscopy; Molecular Conformation; Oligonucleotides; Organophosphonates; Phosphorus

2002
Vinylphosphonate internucleotide linkages inhibit the activity of PcrA DNA helicase.
    Biochemistry, 2002, Jun-18, Volume: 41, Issue:24

    Topics: Adenosine Triphosphatases; Bacterial Proteins; Base Sequence; Binding Sites; DNA; DNA Helicases; DNA, Bacterial; Enzyme Activation; Enzyme Inhibitors; Kinetics; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Nucleic Acid Heteroduplexes; Oligonucleotides; Organophosphonates; Vinyl Compounds

2002
An efficient oxidizing reagent for the synthesis of mixed backbone oligonucleotides via the H-phosphonate approach.
    Bioorganic & medicinal chemistry, 2003, Apr-03, Volume: 11, Issue:7

    Topics: Chromatography, High Pressure Liquid; Indicators and Reagents; Magnetic Resonance Spectroscopy; Oligonucleotides; Organophosphonates; Oxidants; Oxidation-Reduction; Spectrometry, Mass, Electrospray Ionization

2003
Study on reactivity and protection of the alpha-hydroxyphosphonate moiety in 5'-nucleotide analogues: formation of the 3'-O-P-C(OH)-C4' internucleotide linkage.
    Nucleosides, nucleotides & nucleic acids, 2003, Volume: 22, Issue:3

    Topics: Models, Chemical; Molecular Structure; Nucleic Acid Conformation; Nucleotides; Oligodeoxyribonucleotides; Oligonucleotides; Organophosphonates; Pyrimidine Dimers; Stereoisomerism; Thymidine

2003
The substrate activity of (S)-9-[3-hydroxy-(2-phosphonomethoxy)propyl]adenine diphosphate toward DNA polymerases alpha, delta and epsilon.
    Antiviral chemistry & chemotherapy, 2004, Volume: 15, Issue:1

    Topics: Adenine; Animals; Diphosphates; DNA; DNA-Directed DNA Polymerase; Exonucleases; Kinetics; Molecular Structure; Oligonucleotides; Organophosphonates; Organophosphorus Compounds; Proliferating Cell Nuclear Antigen; Rats; Substrate Specificity; Templates, Genetic

2004
Generation of a C-3'-thymidinyl radical in single-stranded oligonucleotides under anaerobic conditions.
    Organic letters, 2004, Jul-08, Volume: 6, Issue:14

    Topics: Base Sequence; Chromatography, High Pressure Liquid; DNA; Oligonucleotides; Organophosphonates; Oxidation-Reduction; Photochemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thymidine

2004
Formation of 4,4'-dimethoxytrityl-C-phosphonate oligonucleotides.
    Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18

    Topics: Chromatography, High Pressure Liquid; Oligonucleotides; Organophosphonates; Phosphites; Structure-Activity Relationship; Trityl Compounds

2004
Di- and oligonucleotide synthesis using H-phosphonate chemistry.
    Methods in molecular biology (Clifton, N.J.), 2005, Volume: 288

    Topics: Oligonucleotides; Organophosphonates

2005
A solid supported reagent for internucleoside H-phosphonate linkage formation.
    Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7

    Topics: Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Chemical; Nucleosides; Oligodeoxyribonucleotides; Oligonucleotides; Organophosphates; Organophosphonates; Oxidants; Spectrometry, Mass, Electrospray Ionization

2005
A cautionary note on the use of the 31P NMR spectroscopy in stereochemical correlation analysis.
    Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7

    Topics: Ethanol; Guanosine; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Conformation; Nucleic Acid Conformation; Oligonucleotides; Organophosphonates; Phosphorus; Phosphorus Isotopes; Protons; Solvents; Spectrophotometry; Stereoisomerism

2005
Universal solid supports for the synthesis of oligonucleotides via a transesterification of H-phosphonate diester linkage.
    The Journal of organic chemistry, 2005, Nov-11, Volume: 70, Issue:23

    Topics: Esterification; Esters; Oligonucleotides; Organophosphonates; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization

2005
Improved synthesis of oligonucleotides with an allylic backbone. Oligonucleotides containing acyclic, achiral nucleoside analogues: N-1 or N-9-[3-hydroxy-2-(hydroxymethyl)prop-1-enyl]nucleobases.
    Organic & biomolecular chemistry, 2006, Mar-21, Volume: 4, Issue:6

    Topics: Amides; Base Sequence; Chromatography, High Pressure Liquid; Indicators and Reagents; Magnetic Resonance Spectroscopy; Models, Molecular; Nucleic Acid Conformation; Nucleosides; Oligonucleotides; Organophosphates; Organophosphonates; Phosphoramides; Phosphoric Acids; Spectrometry, Mass, Fast Atom Bombardment

2006
Synthesis of mixed sequence borane phosphonate DNA.
    Journal of the American Chemical Society, 2006, Jun-28, Volume: 128, Issue:25

    Topics: Boranes; Chromatography, High Pressure Liquid; DNA; Molecular Structure; Oligonucleotides; Organophosphonates

2006
Novel isosteric, isopolar phosphonate analogs of oligonucleotides: preparation and properties.
    Biopolymers, 2006, Volume: 83, Issue:4

    Topics: Circular Dichroism; Computer Simulation; Dimerization; Models, Chemical; Models, Molecular; Oligonucleotides; Organophosphonates; Stereoisomerism

2006
Encapsulation of mono- and oligo-nucleotides into aqueous-core nanocapsules in presence of various water-soluble polymers.
    International journal of pharmaceutics, 2007, Mar-01, Volume: 331, Issue:2

    Topics: Cations; Chitosan; Cidofovir; Cyanoacrylates; Cytosine; Dideoxynucleotides; Drug Carriers; Enbucrilate; Materials Testing; Nanocapsules; Nucleotides; Oligonucleotides; Organophosphonates; Permeability; Polyethyleneimine; Polymers; Solubility; Thymine Nucleotides; Water; Zidovudine

2007
Aerobic fate of the C-3'-thymidinyl radical in single-stranded DNA.
    Chemical research in toxicology, 2006, Volume: 19, Issue:12

    Topics: Aerobiosis; Chromatography, High Pressure Liquid; DNA, Single-Stranded; Oligonucleotides; Organophosphonates; Oxidation-Reduction; Photochemistry; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Thymidine

2006
3'-H-phosphonate synthesis of chiral benzo[a]pyrene diol epoxide adducts at N(2) of deoxyguanosine in oligonucleotides.
    Chemical research in toxicology, 2007, Volume: 20, Issue:2

    Topics: 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide; Chromatography, High Pressure Liquid; Deoxyguanosine; Magnetic Resonance Spectroscopy; Molecular Conformation; Oligonucleotides; Organophosphonates; Sensitivity and Specificity; Stereoisomerism; Time Factors

2007
Enzymatic synthesis of phosphonomethyl oligonucleotides by therminator polymerase.
    Angewandte Chemie (International ed. in English), 2007, Volume: 46, Issue:14

    Topics: DNA Methylation; DNA-Directed DNA Polymerase; Mutation; Oligonucleotides; Organophosphonates; Thermococcus

2007
Nucleoside H-boranophosphonates: synthesis and properties of a new class of nucleotide analogs.
    Nucleic acids symposium series (2004), 2007, Issue:51

    Topics: Boron Compounds; Oligonucleotides; Organophosphonates; Thymidine

2007
Ce(IV)-catalyzed site-selective DNA hydrolysis using tris- and tetrakismethylenephosphonate-modified oligonucleotides.
    Nucleic acids symposium series (2004), 2007, Issue:51

    Topics: Catalysis; Cerium; DNA; Ethylenediamines; Hydrolysis; Oligonucleotides; Organophosphonates; Organophosphorus Compounds

2007
Solid-phase synthesis of backbone-modified DNA analogs by the boranophosphotriester method using new protecting groups for nucleobases.
    Bioorganic & medicinal chemistry letters, 2008, Jul-01, Volume: 18, Issue:13

    Topics: Boranes; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; DNA; Drug Design; Esters; Guanine; Mercaptoethanol; Models, Chemical; Molecular Biology; Molecular Conformation; Oligodeoxyribonucleotides; Oligonucleotides; Organophosphonates; Phosphates

2008
Hydrolysis of single linkage in long DNA using oligonucleotide-multiphosphonate conjugates and Ce IV/EDTA.
    Nucleic acids symposium series (2004), 2008, Issue:52

    Topics: Cerium; DNA; Edetic Acid; Ethylenediamines; Hydrolysis; Oligonucleotides; Organophosphonates; Organophosphorus Compounds

2008
Synthesis of nucleoside 5'-S-methylphosphonates and related compounds.
    Nucleic acids symposium series (2004), 2008, Issue:52

    Topics: Nucleotides; Oligonucleotides; Organophosphonates

2008
From ribonucleoside 5'-aldehydes to ribonucleoside 5'-C-phosphonates as building blocks for oligonucleotide synthesis.
    Nucleic acids symposium series (2004), 2008, Issue:52

    Topics: Aldehydes; Oligonucleotides; Organophosphonates; Ribonucleotides

2008
Enzymatic polymerization of phosphonate nucleosides.
    Chembiochem : a European journal of chemical biology, 2008, Nov-24, Volume: 9, Issue:17

    Topics: DNA Replication; DNA-Directed DNA Polymerase; Electrophoresis, Polyacrylamide Gel; Kinetics; Nucleosides; Oligonucleotides; Organophosphonates; Substrate Specificity; Templates, Genetic

2008
Nucleoside H-boranophosphonates: a new class of boron-containing nucleotide analogues.
    Chemical communications (Cambridge, England), 2009, May-14, Issue:18

    Topics: Boranes; Nucleosides; Oligonucleotides; Organophosphonates

2009
5'-Lipophilic conjugates of oligonucleotides as components of cell delivery systems.
    Nucleic acids symposium series (2004), 2009, Issue:53

    Topics: Lipids; Oligonucleotides; Organophosphonates; Organophosphorus Compounds

2009
Oxidation of an oligonucleotide-bound Ce(III)/multiphosphonate complex for site-selective DNA scission.
    Chemistry (Weinheim an der Bergstrasse, Germany), 2010, Jan-18, Volume: 16, Issue:3

    Topics: Cerium; Coordination Complexes; DNA Cleavage; Ethylenediamines; Hydrolysis; Oligonucleotides; Organophosphonates; Oxidation-Reduction

2010
Manipulation of single-stranded DNA by using an artificial site-selective DNA cutter composed of cerium(IV)/EDTA and phosphonate-oligonucleotide conjugates.
    Chemistry, an Asian journal, 2011, Sep-05, Volume: 6, Issue:9

    Topics: Cerium; DNA, Single-Stranded; Edetic Acid; Escherichia coli; Hydrolysis; Luminescent Proteins; Oligonucleotides; Organophosphonates; Recombinant Proteins

2011
An activated triple bond linker enables 'click' attachment of peptides to oligonucleotides on solid support.
    Nucleic acids research, 2011, Nov-01, Volume: 39, Issue:20

    Topics: Click Chemistry; Copper; Oligonucleotides; Organophosphonates; Peptides

2011
Solution-phase synthesis of branched DNA hybrids via H-phosphonate dimers.
    The Journal of organic chemistry, 2012, Mar-16, Volume: 77, Issue:6

    Topics: Adamantane; DNA; Magnetic Resonance Spectroscopy; Molecular Structure; Oligonucleotides; Organophosphonates; Solutions

2012
Reactive intermediates in the H-phosphonate synthesis of oligonucleotides.
    Organic & biomolecular chemistry, 2012, Aug-14, Volume: 10, Issue:30

    Topics: Chemistry Techniques, Synthetic; Hydrogen; Oligonucleotides; Organophosphonates

2012
Establishment of real time allele specific locked nucleic acid quantitative PCR for detection of HBV YIDD (ATT) mutation and evaluation of its application.
    PloS one, 2014, Volume: 9, Issue:2

    Topics: Adenine; Adult; Alleles; Antiviral Agents; DNA Primers; DNA, Viral; Drug Resistance, Viral; Early Diagnosis; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Isoleucine; Lamivudine; Limit of Detection; Male; Middle Aged; Molecular Sequence Data; Mutation; Nucleotide Motifs; Oligonucleotides; Organophosphonates; Real-Time Polymerase Chain Reaction

2014
Oxidative substitution of boranephosphonate diesters as a route to post-synthetically modified DNA.
    Journal of the American Chemical Society, 2015, Mar-11, Volume: 137, Issue:9

    Topics: Amides; Azides; Boron Compounds; Chemistry Techniques, Synthetic; Dimerization; DNA; Esters; Ethylamines; Iodine; Magnetic Resonance Spectroscopy; Oligonucleotides; Organophosphonates; Oxidation-Reduction; Phosphoric Acids; Stereoisomerism

2015
N-Branched acyclic nucleoside phosphonates as monomers for the synthesis of modified oligonucleotides.
    Organic & biomolecular chemistry, 2015, Apr-21, Volume: 13, Issue:15

    Topics: Adenine; Base Sequence; DNA-Directed DNA Polymerase; Humans; Nucleic Acid Synthesis Inhibitors; Nucleosides; Oligonucleotides; Organophosphonates; Thymine

2015
Solid-Phase Synthesis, Hybridizing Ability, Uptake, and Nuclease Resistant Profiles of Position-Selective Cationic and Hydrophobic Phosphotriester Oligonucleotides.
    The Journal of organic chemistry, 2015, Sep-18, Volume: 80, Issue:18

    Topics: Animals; Cations; Cattle; Cyclohexenes; Exonucleases; HeLa Cells; Humans; Hydrophobic and Hydrophilic Interactions; Jurkat Cells; Nucleic Acid Hybridization; Oligonucleotides; Organophosphonates; Solid-Phase Synthesis Techniques; Temperature

2015
Tuning the hybridization properties of modified oligonucleotides: from flexible to conformationally constrained phosphonate internucleotide linkages.
    Organic & biomolecular chemistry, 2017, Jan-18, Volume: 15, Issue:3

    Topics: Magnetic Resonance Spectroscopy; Molecular Conformation; Molecular Dynamics Simulation; Nucleic Acid Hybridization; Oligonucleotides; Organophosphonates

2017
Nucleoside-O-Methyl-(H)-Phosphinates: Novel Monomers for the Synthesis of Methylphosphonate Oligonucleotides Using H-Phosphonate Chemistry.
    Current protocols in nucleic acid chemistry, 2017, 09-18, Volume: 70

    Topics: Oligonucleotides; Organophosphonates; Organophosphorus Compounds

2017
Synthesis of Chimeric Oligonucleotides Having Modified Internucleotide Linkages via an Automated H-Phosphonate/Phosphoramidite Approach.
    Current protocols in nucleic acid chemistry, 2018, Volume: 73, Issue:1

    Topics: Amides; Automation; Esters; Oligonucleotides; Organophosphonates; Phosphoric Acids; Spectrometry, Mass, Electrospray Ionization

2018
Invading
    Journal of the American Chemical Society, 2019, 07-10, Volume: 141, Issue:27

    Topics: Escherichia coli; Gene Expression; Models, Molecular; Nucleic Acid Conformation; Nucleic Acid Hybridization; Nucleic Acids; Oligonucleotides; Organophosphonates

2019
Enantiodivergent Formation of C-P Bonds: Synthesis of P-Chiral Phosphines and Methylphosphonate Oligonucleotides.
    Journal of the American Chemical Society, 2020, 03-25, Volume: 142, Issue:12

    Topics: Cyclohexane Monoterpenes; Indicators and Reagents; Oligonucleotides; Organophosphonates; Oxidation-Reduction; Phosphines; Stereoisomerism

2020
DNA Analogues Modified at the Nonlinking Positions of Phosphorus.
    Accounts of chemical research, 2020, 10-20, Volume: 53, Issue:10

    Topics: Boranes; DNA; Foscarnet; Oligonucleotides; Organophosphonates; Organophosphorus Compounds; Phosphines; Phosphonoacetic Acid; Phosphorus

2020
Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity.
    Nucleic acids research, 2021, 12-02, Volume: 49, Issue:21

    Topics: Alleles; Humans; Huntington Disease; Oligonucleotides; Organophosphonates; RNA, Small Interfering

2021
Backbone Hydrocarbon-Constrained Nucleic Acids Modulate Hybridization Kinetics for RNA.
    Journal of the American Chemical Society, 2022, 02-02, Volume: 144, Issue:4

    Topics: Hydrocarbons; Kinetics; Molecular Dynamics Simulation; Nucleic Acid Conformation; Nucleic Acid Hybridization; Oligonucleotides; Organophosphonates; RNA

2022