organophosphonates has been researched along with n,n'-((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine) diethyl ester in 10 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (n,n'-((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine) diethyl ester) | Trials (n,n'-((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine) diethyl ester) | Recent Studies (post-2010) (n,n'-((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine) diethyl ester) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 14 | 0 | 5 |
| Protein | Taxonomy | organophosphonates (IC50) | n,n'-((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine) diethyl ester (IC50) |
|---|---|---|---|
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | 0.01 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (50.00) | 29.6817 |
| 2010's | 5 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dang, Q; Erion, MD; Jiang, T; Kasibhatla, SR; Lipscomb, WN; Potter, SC; Reddy, KR; Reddy, MR; van Poelje, PD | 1 |
| Chandramouli, VC; Dang, Q; Erion, MD; Landau, BR; Potter, SC; van Poelje, PD | 1 |
| Tomlinson, B; Wang, Y | 1 |
| Fujiwara, T; Hagisawa, Y; Izumi, M; Ohsumi, J; Okuno, A; Takahashi, K; Yoshida, T | 1 |
| Fujiwara, T; Hagisawa, Y; Kanda, S; Nakashima, R; Ogawa, J; Okuno, A; Takahashi, K; Tanaka, J; Yoshida, T | 1 |
| Lu, J; Xie, Z; Zhang, H; Zhang, WJ; Zhang, Y; Zhou, G | 1 |
| Cashion, DK; Dang, Q; DaRe, J; Erion, MD; Fan, Y; Gibson, T; Jacintho, JD; Jiang, T; Kasibhatla, SR; Lemus, R; Li, H; Li, W; Liu, Y; Potter, SC; Sun, Z; Taplin, F; Tian, F; van Poelje, PD | 1 |
| Fujiwara, T; Hagisawa, Y; Kanda, S; Ogawa, J; Okuno, A; Takahashi, K; Yoshida, T | 1 |
| Carrothers, TJ; Habtemariam, B; Kastrissios, H; Khariton, T; Kshirsagar, S; Mager, DE; Rohatagi, S; Walker, JR | 1 |
| Erion, MD; Potter, SC; van Poelje, PD | 1 |
2 review(s) available for organophosphonates and n,n'-((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine) diethyl ester
| Article | Year |
|---|---|
Managlinat dialanetil, a fructose-1,6-bisphosphatase inhibitor for the treatment of type 2 diabetes.
Topics: Alanine; Animals; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Fructose-Bisphosphatase; Humans; Hypoglycemic Agents; Organophosphonates; Organophosphorus Compounds; Structure-Activity Relationship | 2007 |
Fructose-1, 6-bisphosphatase inhibitors for reducing excessive endogenous glucose production in type 2 diabetes.
Topics: Alanine; Animals; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Humans; Hypoglycemic Agents; Organophosphonates; Organophosphorus Compounds; Signal Transduction | 2011 |
8 other study(ies) available for organophosphonates and n,n'-((5-(2-amino-5-(2-methylpropyl)-4-thiazolyl)-2-furanyl)phosphinylidene)bis(alanine) diethyl ester
| Article | Year |
|---|---|
MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes.
Topics: Adenosine Monophosphate; Alanine; Analysis of Variance; Animals; Carbon Radioisotopes; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Design; Fructose-Bisphosphatase; Gluconeogenesis; Humans; Liver; Male; Molecular Mimicry; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Rats, Zucker; Spectrophotometry; Thiazoles | 2005 |
Inhibition of fructose 1,6-bisphosphatase reduces excessive endogenous glucose production and attenuates hyperglycemia in Zucker diabetic fatty rats.
Topics: Alanine; Animals; Blood Glucose; Body Weight; Cholesterol; Diabetes Mellitus, Type 2; Eating; Female; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Hyperglycemia; Insulin; Ketone Bodies; Lactic Acid; Male; Molecular Structure; Organophosphonates; Organophosphorus Compounds; Pancreas; Rats; Rats, Zucker; Triglycerides | 2006 |
CS-917, a fructose 1,6-bisphosphatase inhibitor, improves postprandial hyperglycemia after meal loading in non-obese type 2 diabetic Goto-Kakizaki rats.
Topics: Alanine; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Administration Schedule; Enzyme Inhibitors; Fructose-Bisphosphatase; Fructosediphosphates; Fructosephosphates; Gluconeogenesis; Hyperglycemia; Liver; Male; Organophosphonates; Organophosphorus Compounds; Rats; Rats, Wistar | 2008 |
Metformin primarily decreases plasma glucose not by gluconeogenesis suppression but by activating glucose utilization in a non-obese type 2 diabetes Goto-Kakizaki rats.
Topics: Alanine; Animals; Blood Glucose; Cells, Cultured; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Hepatocytes; Hypoglycemic Agents; Inhibitory Concentration 50; Insulin; Lactic Acid; Male; Metformin; Organophosphonates; Organophosphorus Compounds; Radioisotope Dilution Technique; Rats; Rats, Mutant Strains; Rats, Wistar | 2009 |
Fructose-1,6-bisphosphatase regulates glucose-stimulated insulin secretion of mouse pancreatic beta-cells.
Topics: Alanine; Animals; Cells, Cultured; Diabetes Mellitus, Type 2; Enzyme Inhibitors; Fructose-Bisphosphatase; Gene Knockdown Techniques; Glucose; Insulin; Insulin Secretion; Insulin-Secreting Cells; Mice; Mice, Inbred C57BL; Organophosphonates; Organophosphorus Compounds; RNA, Small Interfering; Thiazoles; Transfection; Up-Regulation | 2010 |
Discovery of a series of phosphonic acid-containing thiazoles and orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase.
Topics: Administration, Oral; Alanine; Amides; Animals; Biological Availability; Blood Proteins; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Fructose-Bisphosphatase; Humans; Hypoglycemic Agents; Male; Mice; Organophosphonates; Prodrugs; Protein Binding; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiazoles | 2011 |
Contributions of hepatic gluconeogenesis suppression and compensative glycogenolysis on the glucose-lowering effect of CS-917, a fructose 1,6-bisphosphatase inhibitor, in non-obese type 2 diabetes Goto-Kakizaki rats.
Topics: Alanine; Amides; Animals; Blood Glucose; Diabetes Mellitus, Type 2; Drug Evaluation, Preclinical; Fasting; Gluconeogenesis; Glucose; Glycogenolysis; Hypoglycemic Agents; Indoles; Lactic Acid; Male; Organophosphonates; Organophosphorus Compounds; Peptide Hydrolases; Rats | 2011 |
Population pharmacokinetic model for a novel oral hypoglycemic formed in vivo: comparing the use of active metabolite data alone versus using data of upstream and downstream metabolites.
Topics: Aged; Alanine; Computer Simulation; Female; Humans; Hypoglycemic Agents; Male; Middle Aged; Models, Biological; Molecular Structure; Organophosphonates; Prodrugs; Thiazoles | 2012 |