organophosphonates has been researched along with methotrexate in 14 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (methotrexate) | Trials (methotrexate) | Recent Studies (post-2010) (methotrexate) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 41,593 | 5,666 | 11,969 |
| Protein | Taxonomy | organophosphonates (IC50) | methotrexate (IC50) |
|---|---|---|---|
| Thymidylate synthase | Escherichia coli | 1.8 | |
| nuclear receptor coactivator 3 isoform a | Homo sapiens (human) | 0.211 | |
| Toll-like receptor 4 | Homo sapiens (human) | 1.04 | |
| Fatty-acid amide hydrolase 1 | Mus musculus (house mouse) | 0.08 | |
| Dihydrofolate reductase | Homo sapiens (human) | 0.0522 | |
| Dihydrofolate reductase | Mus musculus (house mouse) | 0.0331 | |
| Dihydrofolate reductase | Bos taurus (cattle) | 0.0348 | |
| Dihydrofolate reductase | Gallus gallus (chicken) | 0.0545 | |
| Dihydrofolate reductase | Enterococcus faecium | 0.0014 | |
| Dihydrofolate reductase | Lacticaseibacillus casei | 0.0138 | |
| Thymidylate synthase | Homo sapiens (human) | 0.343 | |
| 5-hydroxytryptamine receptor 2C | Rattus norvegicus (Norway rat) | 0.0147 | |
| Thymidylate synthase | Escherichia coli K-12 | 0.0181 | |
| Dihydrofolate reductase | Escherichia coli K-12 | 0.1529 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Plasmodium falciparum K1 | 0.084 | |
| Folate receptor beta | Homo sapiens (human) | 0.1585 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.0011 | |
| Cytochrome P450 11B1, mitochondrial | Bos taurus (cattle) | 0.0012 | |
| Folate receptor alpha | Homo sapiens (human) | 0.2263 | |
| Dihydrofolate reductase | Pneumocystis carinii | 0.0717 | |
| Histidine decarboxylase | Rattus norvegicus (Norway rat) | 0.0014 | |
| Trifunctional purine biosynthetic protein adenosine-3 | Homo sapiens (human) | 0.01 | |
| Bifunctional purine biosynthesis protein ATIC | Homo sapiens (human) | 0.01 | |
| Delta-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Mu-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Kappa-type opioid receptor | Rattus norvegicus (Norway rat) | 0.003 | |
| Reduced folate transporter | Homo sapiens (human) | 0.012 | |
| Dihydrofolate reductase | Mycobacterium tuberculosis H37Rv | 0.0174 | |
| Folylpolyglutamate synthase, mitochondrial | Homo sapiens (human) | 3.2 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Toxoplasma gondii | 0.0547 | |
| Bifunctional dihydrofolate reductase-thymidylate synthase | Trypanosoma cruzi | 0.11 | |
| Dihydrofolate reductase | Bacillus anthracis | 0.0136 | |
| Dihydrofolate reductase | Rattus norvegicus (Norway rat) | 0.0047 | |
| Proton-coupled folate transporter | Homo sapiens (human) | 0.1207 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (14.29) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 8 (57.14) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Forsch, RA; Freisheim, JH; Kohler, W; Moran, RG; Rosowsky, A | 1 |
| Clarke, L; Rosowsky, A; Waxman, DJ | 1 |
| Balzarini, J; De Clercq, E; Degrève, B; Hatse, S; Naesens, L; Vandeputte, M; Waer, M | 1 |
| Balzarini, J; De Clercq, E; Hatse, S; Naesens, L | 1 |
| Ait Arkoub, Z; Arnulf, B; Chebbi, F; Fillet, AM; Lefrere, F; Varet, B | 1 |
| Agbalika, F; Boulanger, E; Daniel, MT; Grollet, L; Maarek, O; Molina, JM; Oksenhendler, E; Sigaux, F | 1 |
| Cerimele, F; Cesarman, E; Curreli, F; Flore, O; Friedman-Kien, AE; Muralidhar, S; Rosenthal, LJ | 1 |
| Ambudkar, SV; Nandigama, K; Sauna, ZE | 1 |
| Brett, CM; Brown, C; Burchard, EG; Carlson, EJ; Castro, R; Chen, CW; de la Cruz, M; Ferrin, TE; Fujita, K; Fujita, T; Giacomini, KM; Huang, CC; Johns, SJ; Kawamoto, M; Leabman, MK; Lin, ET; Stryke, D; Taylor, T | 1 |
| Bian, JS; Boelsterli, UA; Chan, E; Chan, SY; Duan, W; Ho, PC; Huang, M; Li, X; Tan, TM; Tian, Q; Xiong, W; Yang, H; Zhang, J; Zhou, S; Zhu, YZ | 1 |
| Aebi, C; Leibundgut, K; Ridolfi Lüthy, A; Steiner, I; Wagner, B | 1 |
| Di Martino, V; Herbein, G; Prati, C; Toussirot, E; Wendling, D | 1 |
| Hackenbroch, M; Hallek, M; Rath, T; Rubbert, A; Saech, J | 1 |
| Ambudkar, SV; Cheepala, SB; Ekins, S; Fukuda, Y; Schuetz, JD; Sparreboom, A; Takenaka, K; Wu, CP | 1 |
1 review(s) available for organophosphonates and methotrexate
| Article | Year |
|---|---|
A clinical, molecular and cytogenetic study of 12 cases of human herpesvirus 8 associated primary effusion lymphoma in HIV-infected patients.
Topics: Adult; Anti-HIV Agents; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Bleomycin; Chromosome Aberrations; Cidofovir; Cyclophosphamide; Cytosine; Doxorubicin; Drug Therapy, Combination; Etoposide; Gene Rearrangement, B-Lymphocyte, Heavy Chain; Herpesviridae Infections; Herpesvirus 8, Human; Humans; Immunophenotyping; Interferon-alpha; Karyotyping; Lymphoma, AIDS-Related; Lymphoma, B-Cell; Lymphoma, Large-Cell, Immunoblastic; Male; Methotrexate; Middle Aged; Organophosphonates; Organophosphorus Compounds; Polymerase Chain Reaction; Prednisone; Prognosis; Remission Induction; Survival Analysis; Vincristine; Vindesine; Viral Load | 2001 |
13 other study(ies) available for organophosphonates and methotrexate
| Article | Year |
|---|---|
Methotrexate analogues. 32. Chain extension, alpha-carboxyl deletion, and gamma-carboxyl replacement by sulfonate and phosphonate: effect on enzyme binding and cell-growth inhibition.
Topics: Aminopterin; Animals; Cell Division; Chemical Phenomena; Chemistry; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Liver; Methotrexate; Mice; Organophosphonates; Peptide Synthases; Structure-Activity Relationship; Sulfonic Acids | 1988 |
Inhibition of human liver folylpolyglutamate synthetase by non-gamma-glutamylatable antifolate analogs.
Topics: Amines; Aminopterin; Folic Acid Antagonists; Humans; Kinetics; Liver; Methotrexate; Organophosphonates; Peptide Synthases; Structure-Activity Relationship; Sulfonic Acids | 1987 |
In vitro and in vivo inhibitory activity of the differentiation-inducing agent 9-(2-phosphonylmethoxyethyl)adenine (PMEA) against rat choriocarcinoma.
Topics: Adenine; Alkaline Phosphatase; Animals; Antineoplastic Agents; Cell Differentiation; Cell Division; Choriocarcinoma; Methotrexate; Organophosphonates; Progesterone; Rats; Rats, Inbred Strains; Stereoisomerism | 1998 |
Potent differentiation-inducing properties of the antiretroviral agent 9-(2-phosphonylmethoxyethyl) adenine (PMEA) in the rat choriocarcinoma (RCHO) tumor cell model.
Topics: Adenine; Alkaline Phosphatase; Animals; Antigens, Neoplasm; Antigens, Surface; Antiviral Agents; Cell Differentiation; Cell Survival; Choriocarcinoma; Drug Therapy, Combination; Enzyme Induction; Growth Inhibitors; Kidney Neoplasms; Methotrexate; Organophosphonates; Organophosphorus Compounds; Progesterone; Rats; Rats, Inbred Strains; Rats, Wistar; Retroviridae; Tenofovir; Trophoblasts; Tumor Cells, Cultured | 1998 |
Multiple herpes simplex virus infections with various resistance patterns in a matched unrelated donor transplant recipient.
Topics: Acyclovir; Antineoplastic Agents, Alkylating; Antiviral Agents; Bone Marrow Transplantation; Cidofovir; Combined Modality Therapy; Cyclosporine; Cytarabine; Cytomegalovirus Infections; Cytosine; Drug Resistance, Viral; Fatal Outcome; Foscarnet; Graft vs Host Disease; Herpes Genitalis; Herpes Simplex; Humans; Hydroxyurea; Immunocompromised Host; Immunosuppressive Agents; Interferons; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Methotrexate; Middle Aged; Organophosphonates; Organophosphorus Compounds; Simplexvirus; Transplantation Conditioning; Whole-Body Irradiation | 2001 |
Transcriptional downregulation of ORF50/Rta by methotrexate inhibits the switch of Kaposi's sarcoma-associated herpesvirus/human herpesvirus 8 from latency to lytic replication.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antiviral Agents; Cidofovir; Cytosine; Down-Regulation; Drug Resistance; Foscarnet; Herpesvirus 8, Human; Humans; Immediate-Early Proteins; Interleukin-6; Methotrexate; Neuropeptides; Nucleic Acid Synthesis Inhibitors; Open Reading Frames; Organophosphonates; Organophosphorus Compounds; Trans-Activators; Transcription, Genetic; Tumor Cells, Cultured; Viral Proteins; Virus Activation; Virus Latency; Virus Replication | 2002 |
Multidrug resistance protein 4 (ABCC4)-mediated ATP hydrolysis: effect of transport substrates and characterization of the post-hydrolysis transition state.
Topics: Adenine; Adenosine Diphosphate; Adenosine Triphosphatases; Adenosine Triphosphate; Animals; Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beryllium; Biological Transport; Catalysis; Cations; Cell Line; Cell Membrane; Chelating Agents; Cobalt; Dinoprostone; DNA, Complementary; Dose-Response Relationship, Drug; Edetic Acid; Fluorides; Humans; Hydrolysis; Insecta; Kinetics; Magnesium; Manganese; Methotrexate; Models, Biological; Multidrug Resistance-Associated Proteins; Nucleotides; Organophosphonates; Protein Binding; Substrate Specificity; Vanadates; Zidovudine | 2004 |
Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1).
Topics: Adenine; Adult; Animals; Anions; Antineoplastic Agents; DNA, Complementary; Genetic Variation; Genotype; Haplotypes; Heterozygote; Humans; Kidney; Kinetics; Male; Methotrexate; Models, Chemical; Models, Genetic; Mycotoxins; Ochratoxins; Organic Anion Transport Protein 1; Organic Anion Transporters; Organophosphonates; p-Aminohippuric Acid; Pedigree; Pharmacogenetics; Polymorphism, Genetic; Protein Structure, Secondary; RNA, Complementary; Xenobiotics; Xenopus laevis | 2005 |
Human multidrug resistance associated protein 4 confers resistance to camptothecins.
Topics: Adenine; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Line; Drug Resistance, Neoplasm; Glutathione; Humans; Irinotecan; Methotrexate; Multidrug Resistance-Associated Proteins; Organophosphonates; Paclitaxel | 2005 |
Fatal adenovirus hepatitis during maintenance therapy for childhood acute lymphoblastic leukemia.
Topics: Adenovirus Infections, Human; Antineoplastic Combined Chemotherapy Protocols; Antiviral Agents; Asparaginase; Child, Preschool; Cidofovir; Computer Systems; Cytosine; DNA, Viral; Fatal Outcome; Hepatitis, Viral, Human; Humans; Immunocompromised Host; Male; Mercaptopurine; Methotrexate; Multiple Organ Failure; Organophosphonates; Polymerase Chain Reaction; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Prednisolone; Vincristine; Viremia | 2008 |
Spondyloarthropathy and chronic B hepatitis. Effect of anti-TNF therapy.
Topics: Adenine; Adult; Antibodies, Monoclonal; Antirheumatic Agents; Antiviral Agents; Drug Therapy, Combination; Etanercept; Female; Hepatitis B virus; Hepatitis B, Chronic; Humans; Immunocompromised Host; Immunoglobulin G; Infliximab; Lamivudine; Male; Methotrexate; Organophosphonates; Receptors, Tumor Necrosis Factor; Spondylarthropathies; Treatment Outcome; Tumor Necrosis Factor-alpha; Viral Load; Virus Activation | 2009 |
Longterm remission of more than 5 years in a patient with progressive multifocal leucoencephalopathy and sarcoidosis.
Topics: Anti-Inflammatory Agents; Antiviral Agents; Brain; Cidofovir; Cytosine; Female; Gait Disorders, Neurologic; Humans; Immunosuppressive Agents; Leukoencephalopathy, Progressive Multifocal; Magnetic Resonance Imaging; Methotrexate; Mianserin; Middle Aged; Mirtazapine; Organophosphonates; Prednisolone; Receptor, Serotonin, 5-HT2A; Sarcoidosis; Serotonin Antagonists | 2012 |
Human immunodeficiency virus protease inhibitors interact with ATP binding cassette transporter 4/multidrug resistance protein 4: a basis for unanticipated enhanced cytotoxicity.
Topics: Adenine; Animals; Antineoplastic Agents; Cell Line; Cell Line, Tumor; Cell Proliferation; Drug Interactions; Female; HIV Protease Inhibitors; Humans; Hydrolysis; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Molecular; Multidrug Resistance-Associated Proteins; Nelfinavir; Organophosphonates; Ritonavir | 2013 |