Page last updated: 2024-09-05

organophosphonates and leucine

organophosphonates has been researched along with leucine in 15 studies

Compound Research Comparison

Studies
(organophosphonates)
Trials
(organophosphonates)
Recent Studies (post-2010)
(organophosphonates)
Studies
(leucine)
Trials
(leucine)
Recent Studies (post-2010) (leucine)
9,9688803,59628,5157444,178

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's1 (6.67)18.2507
2000's7 (46.67)29.6817
2010's4 (26.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Mizuno, S; Rabinovitz, M1
Asherson, GL; Becker, EL; Ferluga, J1
Anderson, JW; Fewden, L1
Lipscomb, WN; Sträter, N1
Bennett, B; Edwards, T; Holz, RC; Petsko, G; Ringe, D; Stamper, C1
Cierpicki, T; Grembecka, J; Kafarski, P; Mucha, A1
Clark, T; Lanig, H; Schürer, G1
Drag, M; Grembecka, J; Kafarski, P; Pawełczak, M1
Bettigeri, S; Chen, CT; Kao, JQ; Pawar, VD; Weng, SS1
Feng, YQ; Li, T; Lin, B; Yu, QW1
Fujimoto, M; Hori, M; Murata, T; Oka, T; Ozaki, H1
Bhadury, P; Fan, H; Li, X; Liu, J; Wang, Z; Wu, J; Xu, W; Yang, S1
Kafarski, P; Kim, Y; Piergies, N; Podstawka-Proniewicz, E; Proniewicz, LM; Skołuba, D1
Aboul-Enein, HY; Liu, B; Yang, GS; Zhou, Y1
Ballow, C; Battegay, M; Elgadi, M; Feifel, U; Fuhr, R; Girlich, B; Haschke, M; Kort, J; Lang, B; Li, Y; Sabo, JP; Schobelock, M1

Trials

1 trial(s) available for organophosphonates and leucine

ArticleYear
Clinical assessment of potential drug interactions of faldaprevir, a hepatitis C virus protease inhibitor, with darunavir/ritonavir, efavirenz, and tenofovir.
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2014, Nov-15, Volume: 59, Issue:10

    Topics: Adenine; Adult; Alkynes; Aminoisobutyric Acids; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Benzoxazines; Coinfection; Cyclopropanes; Darunavir; Drug Interactions; Female; Healthy Volunteers; Hepacivirus; Hepatitis C; HIV Infections; HIV-1; Humans; Leucine; Male; Middle Aged; Oligopeptides; Organophosphonates; Proline; Protease Inhibitors; Quinolines; Ritonavir; Sulfonamides; Tenofovir; Thiazoles; Young Adult

2014

Other Studies

14 other study(ies) available for organophosphonates and leucine

ArticleYear
Factor-promoted dissociation of free ribosomes in a rabbit reticulocyte lysate system: inhibition and requirement for an energy source.
    Proceedings of the National Academy of Sciences of the United States of America, 1973, Volume: 70, Issue:3

    Topics: Adenosine Triphosphate; Animals; Carbon Isotopes; Cell-Free System; Creatine Kinase; Cycloheximide; Globins; Guanine Nucleotides; Guanosine Triphosphate; Leucine; Organophosphonates; Peptide Chain Termination, Translational; Peptide Initiation Factors; Phosphocreatine; Rabbits; Reticulocytes; Ribosomes; Tricarboxylic Acids

1973
The effect of organophosphorus inhibitors, p-nitrophenol and cytochalasin B on cytotoxic killing of tumour cells by immune spleen cells, and the effect of shaking.
    Immunology, 1972, Volume: 23, Issue:4

    Topics: Animals; Carbon Isotopes; Cell Membrane; Cell Movement; Chickens; Chromium Isotopes; Cytotoxicity Tests, Immunologic; Esterases; Hydrolysis; Immunity, Cellular; Leucine; Mast-Cell Sarcoma; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mycotoxins; Nitrophenols; Organophosphonates; Organophosphorus Compounds; Spleen; Uridine; Vibration

1972
1-amino-2-phenylethane 1-phosphonic acid: a specific competitive inhibitor of phenylalanyl-tRNA synthetase.
    Chemico-biological interactions, 1970, Volume: 2, Issue:1

    Topics: Amino Acyl-tRNA Synthetases; Kinetics; Leucine; Organophosphonates; Phenylalanine; Plants; Threonine; Tyrosine; Valine

1970
Transition state analogue L-leucinephosphonic acid bound to bovine lens leucine aminopeptidase: X-ray structure at 1.65 A resolution in a new crystal form.
    Biochemistry, 1995, Jul-18, Volume: 34, Issue:28

    Topics: Amino Acid Sequence; Animals; Anti-Bacterial Agents; Binding Sites; Cattle; Crystallography, X-Ray; Hydrogen Bonding; In Vitro Techniques; Lens, Crystalline; Leucine; Leucyl Aminopeptidase; Models, Molecular; Molecular Sequence Data; Molecular Structure; Organophosphonates; Peptides

1995
Inhibition of the aminopeptidase from Aeromonas proteolytica by L-leucinephosphonic acid. Spectroscopic and crystallographic characterization of the transition state of peptide hydrolysis.
    Biochemistry, 2001, Jun-19, Volume: 40, Issue:24

    Topics: Aeromonas; Aminopeptidases; Binding, Competitive; Catalysis; Crystallization; Crystallography, X-Ray; Electron Spin Resonance Spectroscopy; Enzyme Inhibitors; Hydrolysis; Kinetics; Leucine; Macromolecular Substances; Organophosphonates; Peptides; Protein Binding; Spectrophotometry, Ultraviolet; Thermodynamics

2001
The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.
    Journal of medicinal chemistry, 2003, Jun-19, Volume: 46, Issue:13

    Topics: Animals; Binding Sites; Cattle; CD13 Antigens; Crystallography, X-Ray; Dipeptides; Drug Stability; Enzyme Inhibitors; Lens, Crystalline; Leucine; Leucyl Aminopeptidase; Models, Molecular; Molecular Structure; Organophosphonates; Organophosphorus Compounds; Phosphinic Acids; Protein Binding; Stereoisomerism; Structure-Activity Relationship

2003
Aeromonas proteolytica aminopeptidase: an investigation of the mode of action using a quantum mechanical/molecular mechanical approach.
    Biochemistry, 2004, May-11, Volume: 43, Issue:18

    Topics: Aeromonas; Alanine; Aminopeptidases; Animals; Bacterial Proteins; Binding Sites; Catalysis; Cations, Divalent; Cattle; Computers, Molecular; Enzyme Activation; Enzyme Inhibitors; Enzyme Stability; Hydrogen Bonding; Hydrolysis; Hydroxides; Leucine; Models, Chemical; Models, Molecular; Organophosphonates; Static Electricity; Substrate Specificity; Zinc

2004
alpha-Aminoalkylphosphonates as a tool in experimental optimisation of P1 side chain shape of potential inhibitors in S1 pocket of leucine- and neutral aminopeptidases.
    European journal of medicinal chemistry, 2005, Volume: 40, Issue:8

    Topics: Aminopeptidases; Animals; Binding Sites; Hydrogen-Ion Concentration; Kidney; Leucine; Leucyl Aminopeptidase; Molecular Structure; Organophosphonates; Structure-Activity Relationship

2005
Highly enantioselective aerobic oxidation of alpha-hydroxyphosphonates catalyzed by chiral vanadyl(V) methoxides bearing N-salicylidene-alpha-aminocarboxylates.
    Journal of the American Chemical Society, 2006, May-17, Volume: 128, Issue:19

    Topics: Amino Acids; Catalysis; Leucine; Organophosphonates; Oxidation-Reduction; Oxygen; Stereoisomerism; Vanadates

2006
Synthesis and chromatographic properties of a chiral stationary phase derived from bovine serum albumin immobilized on magnesia-zirconia using phosphonate spacers.
    Journal of separation science, 2007, Volume: 30, Issue:6

    Topics: Animals; Cattle; Chromatography, Liquid; Dansyl Compounds; Dinitrobenzenes; Fosfomycin; Leucine; Magnesium Oxide; Molecular Structure; Organic Chemicals; Organophosphonates; Pharmaceutical Preparations; Phenylalanine; Serum Albumin, Bovine; Spectroscopy, Fourier Transform Infrared; Stereoisomerism; Temperature; Tryptophan; Valine; Zirconium

2007
Fluvastatin inhibits mast cell degranulation without changing the cytoplasmic Ca2+ level.
    European journal of pharmacology, 2009, Jan-14, Volume: 602, Issue:2-3

    Topics: Alkyl and Aryl Transferases; Calcium; Cell Degranulation; Cell Proliferation; Cell Survival; Cholesterol; Cytoplasm; Cytoplasmic Granules; Dinitrophenols; Enzyme Inhibitors; Fatty Acids, Monounsaturated; Fluvastatin; Humans; Indoles; Intracellular Space; Leucine; Mast Cells; Mevalonic Acid; Organophosphonates; Polyisoprenyl Phosphates; Serum Albumin; Thapsigargin

2009
Synthesis and antiviral bioactivity of chiral thioureas containing leucine and phosphonate moieties.
    Molecules (Basel, Switzerland), 2010, Jul-29, Volume: 15, Issue:8

    Topics: Antiviral Agents; Leucine; Organophosphonates; Solvents; Thiourea; Tobacco Mosaic Virus

2010
Vibrational characterization of L-leucine phosphonate analogues: FT-IR, FT-Raman, and SERS spectroscopy studies and DFT calculations.
    The journal of physical chemistry. A, 2011, Oct-13, Volume: 115, Issue:40

    Topics: Leucine; Organophosphonates; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Vibration

2011
Enantioseparation of four organophosphonate derivatives on N-(3,5-dinitrobenzoyl)-L-leucine-n-propylamide stationary phase by molecular modeling.
    Chirality, 2013, Volume: 25, Issue:2

    Topics: Chromatography, High Pressure Liquid; Leucine; Molecular Conformation; Molecular Dynamics Simulation; Organophosphonates; Stereoisomerism

2013