Page last updated: 2024-09-05

organophosphonates and indomethacin

organophosphonates has been researched along with indomethacin in 13 studies

Compound Research Comparison

Studies
(organophosphonates)
Trials
(organophosphonates)
Recent Studies (post-2010)
(organophosphonates)
Studies
(indomethacin)
Trials
(indomethacin)
Recent Studies (post-2010) (indomethacin)
9,9688803,59629,5271,8383,396

Protein Interaction Comparison

ProteinTaxonomyorganophosphonates (IC50)indomethacin (IC50)
Chain A, membrane-associated prostaglandin E synthase-2Macaca fascicularis (crab-eating macaque)1000
Prostaglandin-H2 D-isomeraseMus musculus (house mouse)1.1
Multidrug resistance-associated protein 4Homo sapiens (human)5.8
Prostaglandin G/H synthase 1 Bos taurus (cattle)0.9994
Prostaglandin G/H synthase 2 Bos taurus (cattle)0.7764
Cytochrome c oxidase subunit 2Homo sapiens (human)0.34
Prostaglandin G/H synthase 1Ovis aries (sheep)0.5605
Neuronal acetylcholine receptor subunit alpha-4Rattus norvegicus (Norway rat)0.004
Interleukin-8Homo sapiens (human)0.05
Neuronal acetylcholine receptor subunit beta-2Rattus norvegicus (Norway rat)0.004
Aldo-keto reductase family 1 member B1Homo sapiens (human)6
Aldo-keto reductase family 1 member B1Bos taurus (cattle)5
Prostaglandin G/H synthase 1Mus musculus (house mouse)0.011
Prostaglandin G/H synthase 1Homo sapiens (human)0.4848
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)0.2
Thromboxane-A synthase Homo sapiens (human)0.1
Indoleamine 2,3-dioxygenase 1Mus musculus (house mouse)0.082
Nitric oxide synthase, inducibleMus musculus (house mouse)4.5
Substance-P receptorCavia porcellus (domestic guinea pig)5.7
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)0.2
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)0.2
Prostaglandin G/H synthase 2Homo sapiens (human)1.5128
Prostaglandin G/H synthase 2 Rattus norvegicus (Norway rat)0.5504
Aldo-keto reductase family 1 member C3Homo sapiens (human)3.4486
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)0.2
C-X-C chemokine receptor type 3Homo sapiens (human)0.05
Aldo-keto reductase family 1 member C2 Homo sapiens (human)8.97
Prostaglandin G/H synthase 2Ovis aries (sheep)3.4647
Prostaglandin G/H synthase 2Mus musculus (house mouse)0.4233
Solute carrier family 22 member 6Homo sapiens (human)3
Sigma intracellular receptor 2Rattus norvegicus (Norway rat)0.49
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)7.7
Prostaglandin G/H synthase 1 Rattus norvegicus (Norway rat)0.5461
P2Y purinoceptor 12Rattus norvegicus (Norway rat)0.96

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19905 (38.46)18.7374
1990's3 (23.08)18.2507
2000's5 (38.46)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tai, HH; Yuan, B1
Barbieri, EJ; Khanna, OP; McMichael, R1
Lowe, NJ; Stoughton, RB; Virgadamo, F1
Eakins, KE; Kulkarni, PS2
Aoyagi, T; Matsui, K; Nagase, Y; Yamamura, M1
Franková, D; Holý, A; Zídek, Z1
Balzarini, J; De Clercq, E; Hatse, S1
Davies, JE; Jennings, SC; Ng, LL; Pettit, AI; Quinn, PA; Wong, RK1
Albano, RM; Assis, MC; Bozza, PT; Coelho, MG; Gayer, CR; Lopes, UG; Marques, EA; Nascimento, DO; Paiva, DD; Plotkowski, MC; Raymond, B; Saliba, AM; Silva, MC; Touqui, L1
Haneji, T; Nagata, T; Shinohara, H; Yoshida, K1
Hrabálek, A; Janůsová, B; Kovaríková, P; Novotný, J; Novotný, M; Vávrová, K1
Balasubramanian, KA; Basivireddy, J; Jacob, M; Pulimood, AB; Sivalingam, N1

Other Studies

13 other study(ies) available for organophosphonates and indomethacin

ArticleYear
Studies on the thromboxane synthesizing system in human platelet microsomes.
    Biochimica et biophysica acta, 1978, Dec-22, Volume: 531, Issue:3

    Topics: Arachidonic Acids; Benzimidazoles; Blood Platelets; Humans; Indomethacin; Kinetics; Microsomes; Organophosphonates; Organophosphorus Compounds; Prostaglandin Antagonists; Prostaglandin Endoperoxides, Synthetic; Prostaglandins H; Sulfhydryl Reagents; Thromboxane-A Synthase; Thromboxanes

1978
Effects of prostaglandins on vesicourethral smooth muscle of rabbit. Therapeutic implications.
    Urology, 1978, Volume: 12, Issue:6

    Topics: Acetylcholine; Animals; Barium; Female; Histamine; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle, Smooth; Norepinephrine; Organophosphonates; Organophosphorus Compounds; Prostaglandin Antagonists; Prostaglandins E; Prostaglandins F; Rabbits; Receptors, Prostaglandin; Urethra; Urinary Bladder; Urination Disorders

1978
Anti-inflammatory properties of a prostaglandin antagonist, a corticosteroid and indomethacin in experimental contact dermatitis.
    The British journal of dermatology, 1977, Volume: 96, Issue:4

    Topics: Administration, Topical; Animals; Anti-Inflammatory Agents; Dermatitis, Contact; Erythema; Indomethacin; Inflammation; Injections, Intraperitoneal; Mice; Organophosphonates; Oxazolone; Prostaglandin Antagonists; Triamcinolone Acetonide

1977
Selective inhibitory actions of sodium-p-benzyl-4-[1-oxo-2-(4-chlorobenzyl)-3-phenyl propyl] phenyl phosphonate (N-0161) and indomethacin on the biosynthesis of prostaglandins and thromboxanes from arachidonic acid.
    British journal of pharmacology, 1977, Volume: 60, Issue:1

    Topics: Animals; Arachidonic Acids; Arteries; Biological Assay; Blood Platelets; Depression, Chemical; Dogs; Female; Humans; Hydroxy Acids; In Vitro Techniques; Indomethacin; Kidney Medulla; Male; Microsomes; Muscle Contraction; Muscle, Smooth; Organophosphonates; Organophosphorus Compounds; Peroxides; Prostaglandin Antagonists; Prostaglandins; Prostaglandins E; Pyrans; Rabbits; Seminal Vesicles; Sheep

1977
N-0164 inhibits generation of thromboxane-A2-like activity from prostaglandin endoperoxides by human platelet microsomes.
    Prostaglandins, 1976, Volume: 12, Issue:3

    Topics: Animals; Aorta; Arachidonic Acids; Blood Platelets; Humans; Hydroxy Acids; Indomethacin; Male; Microsomes; Muscle Contraction; Organophosphonates; Peroxides; Prostaglandin Antagonists; Prostaglandins; Pyrans; Rabbits; Rats; Stomach

1976
Preparations of phosphonate, phosphoramidate and phosphate derivatives and their evaluation as transdermal penetration enhancers.
    Drug design and discovery, 1991, Volume: 8, Issue:1

    Topics: Administration, Cutaneous; Animals; Indomethacin; Male; Organophosphonates; Organophosphorus Compounds; Phosphates; Rabbits; Skin Absorption

1991
Antiretroviral agent (R)-9-(2-phosphonomethoxypropyl)adenine stimulates cytokine and nitric oxide production.
    European journal of pharmacology, 1997, Jul-23, Volume: 331, Issue:2-3

    Topics: Adenine; Adjuvants, Immunologic; Animals; Anti-HIV Agents; Anti-Inflammatory Agents, Non-Steroidal; Cells, Cultured; Culture Media; Cytokines; Female; Immunohistochemistry; Indomethacin; Interferon-gamma; Interleukin-10; Macrophages; Mice; Mice, Inbred C57BL; Nitric Oxide; Organophosphonates; Organophosphorus Compounds; Phosphodiesterase Inhibitors; Stimulation, Chemical; Tenofovir; Theophylline; Tumor Necrosis Factor-alpha

1997
Enhanced 9-(2-phosphonylmethoxyethyl)adenine secretion by a specific, indomethacin-sensitive efflux pump in a mutant 9-(2-phosphonylmethoxyethyl)adenine-resistant human erythroleukemia K562 cell line.
    Molecular pharmacology, 1998, Volume: 54, Issue:5

    Topics: Adenine; Adenine Nucleotides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antimetabolites; Antiviral Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP-Binding Cassette Transporters; Biological Transport; Cycloheximide; Dactinomycin; Drug Resistance, Neoplasm; Extracellular Space; Flow Cytometry; Humans; Immunoblotting; Indomethacin; K562 Cells; Mice; Multidrug Resistance-Associated Proteins; Mutation; Organophosphonates; Prodrugs; Protein Synthesis Inhibitors; Sensitivity and Specificity; Temperature; Zidovudine

1998
Advanced glycation end products stimulate an enhanced neutrophil respiratory burst mediated through the activation of cytosolic phospholipase A2 and generation of arachidonic Acid.
    Circulation, 2003, Oct-14, Volume: 108, Issue:15

    Topics: Acetylcysteine; Adult; Arachidonic Acid; Arachidonic Acids; Cells, Cultured; Enzyme Inhibitors; Glycation End Products, Advanced; Group IV Phospholipases A2; Humans; Indomethacin; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Organophosphonates; Oxidation-Reduction; Phospholipases A; Phospholipases A2; Quinacrine; Reactive Oxygen Species; Respiratory Burst; Vascular Diseases

2003
Eicosanoid-mediated proinflammatory activity of Pseudomonas aeruginosa ExoU.
    Cellular microbiology, 2005, Volume: 7, Issue:12

    Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Bacterial Proteins; Bacterial Toxins; Cell Line; Dinoprostone; Eicosanoids; Endothelial Cells; Epoprostenol; Female; Group IV Phospholipases A2; Humans; Ibuprofen; Indomethacin; Inflammation; Lipoxygenase Inhibitors; Masoprocol; Mice; Mice, Inbred BALB C; Organophosphonates; Phospholipases A; Pseudomonas aeruginosa; Pseudomonas Infections

2005
Arachidonic acid inhibits osteoblast differentiation through cytosolic phospholipase A2-dependent pathway.
    Oral diseases, 2007, Volume: 13, Issue:1

    Topics: 3T3 Cells; Alkaline Phosphatase; Animals; Arachidonic Acid; Arachidonic Acids; Cell Differentiation; Cell Shape; Clone Cells; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Cytosol; Dinoprostone; Enzyme Inhibitors; Fibroblasts; Indomethacin; Mice; Nitrobenzenes; Organophosphonates; Osteoblasts; Phospholipases A; Phospholipases A2; Prostaglandin-Endoperoxide Synthases; Prostaglandins; RNA, Messenger; Sulfonamides

2007
Dimethylamino acid esters as biodegradable and reversible transdermal permeation enhancers: effects of linking chain length, chirality and polyfluorination.
    Pharmaceutical research, 2009, Volume: 26, Issue:4

    Topics: Adenine; Administration, Cutaneous; Alanine; Animals; Caproates; Chemistry, Pharmaceutical; Dimethylamines; Dodecanol; Drug Carriers; Drug Compounding; Drug Stability; Electric Impedance; Esterases; Halogenation; Hydrocortisone; Hydrolysis; Indomethacin; Isomerism; Methylamines; Molecular Structure; Organophosphonates; Skin; Skin Absorption; Structure-Activity Relationship; Swine; Theophylline; Time Factors

2009
Activation of phospholipase A2 is involved in indomethacin-induced damage in Caco-2 cells.
    Toxicology in vitro : an international journal published in association with BIBRA, 2009, Volume: 23, Issue:5

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Caco-2 Cells; Cell Survival; Enzyme Inhibitors; Humans; Indomethacin; Lysophospholipids; Organophosphonates; Oxidative Stress; Phospholipases A2, Cytosolic

2009