Page last updated: 2024-09-05

organophosphonates and guanosine

organophosphonates has been researched along with guanosine in 16 studies

Compound Research Comparison

Studies (organophosphonates)	Trials (organophosphonates)	Recent Studies (post-2010) (organophosphonates)	Studies (guanosine)	Trials (guanosine)	Recent Studies (post-2010) (guanosine)
9,968	880	3,596	4,442	26	1,036

Research

Studies (16)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (12.50)	18.2507
2000's	10 (62.50)	29.6817
2010's	4 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Baba, M; De Clercq, E; Konno, K; Shigeta, S; Yokota, T	1
Bedard, J; Bowlin, T; Chan, L; Drach, J; Huffman, J; Lis, M; May, S; Rando, R; Sidwell, R; Tryphonas, L	1
Gallant, JE	1
Forconi, M; Herschlag, D	1
Parker, WB; Rose, JD; Secrist, JA	1
Jankowska, J; Kraszewski, A; Sobkowski, M; Stawinski, J	1
Boojamra, CG; Callebaut, C; Cihlar, T; Gao, Y; Hui, H; Lin, KY; Mackman, RL; Ray, AS; Stray, K; Vela, JE; Zhang, L	1
Boojamra, CG; Carey, A; Chen, J; Cihlar, T; Douglas, JL; Gao, Y; Grant, D; Hui, H; Laflamme, G; Lin, KY; Mackman, RL; Myrick, F; Pakdaman, R; Parkin, NT; Ray, AS; Vela, JE; White, KL; Zhang, L	1
Chayama, K; Takahashi, S	1
Boojamra, CG; Cihlar, T; Douglas, J; Grant, D; Hui, H; Lin, KY; Mackman, RL; Petrakovsky, O; Prasad, V; Ray, AS	1
Boojamra, CG; Cihlar, T; Douglas, J; Grant, D; Kim, CU; Mackman, RL; Markevitch, DY; Prasad, V; Ray, AS	1
Carey, AC; Cihlar, T; Fisher, R; Laflamme, G; Mackman, R; Ray, AS; Vela, JE	1
Birkus, G; Boojamra, CG; Cihlar, T; Desai, MC; Douglas, JL; Gao, Y; Grant, D; Hui, HC; Laflamme, G; Lin, KY; Mackman, RL; Markevitch, DY; McDermott, M; Mishra, R; Pakdaman, R; Petrakovsky, OV; Ray, AS; Vela, JE; Zhang, L	1
De Clercq, E	1
Ali-von Laue, C; Blaschke, T; Do, N; Hoeller Obrigkeit, D; Korting, HC; Kramer, KD; Küchler, S; Lehnen, D; Mehnert, W; Merk, HF; Plendl, J; Schäfer-Korting, M; Weindl, G; Zoschke, C	1
Andrei, G; Głowacka, IE; Piotrowska, DG; Schols, D; Snoeck, R	1

Reviews

2 review(s) available for organophosphonates and guanosine

Article	Year
[Attention-getting sexually transmitted diseases: Hepatitis B]. Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Nov-10, Volume: 96, Issue:11 Topics: Adenine; Adenosine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Genotype; Guanine; Guanosine; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Sexually Transmitted Diseases, Viral	2007
The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond. Biochemical pharmacology, 2011, Jul-15, Volume: 82, Issue:2 Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cidofovir; Cytosine; Guanosine; Hepatitis B; HIV Infections; Humans; Organophosphonates; Prodrugs; Structure-Activity Relationship; Tenofovir	2011

Article

Year

[Attention-getting sexually transmitted diseases: Hepatitis B].

Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 2007, Nov-10, Volume: 96, Issue:11

Topics: Adenine; Adenosine; Antiviral Agents; Comorbidity; Drug Therapy, Combination; Genotype; Guanine; Guanosine; Hepatitis B; Hepatitis B virus; HIV Infections; Humans; Lamivudine; Organophosphonates; Reverse Transcriptase Inhibitors; Sexually Transmitted Diseases, Viral

2007

The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond.

Biochemical pharmacology, 2011, Jul-15, Volume: 82, Issue:2

Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cidofovir; Cytosine; Guanosine; Hepatitis B; HIV Infections; Humans; Organophosphonates; Prodrugs; Structure-Activity Relationship; Tenofovir

2011

Other Studies

14 other study(ies) available for organophosphonates and guanosine

Article	Year
Comparative inhibitory effects of nucleoside analogues on different clinical isolates of human cytomegalovirus in vitro. The Journal of infectious diseases, 1991, Volume: 163, Issue:2 Topics: Adenine; Adenosine; Antiviral Agents; Cell Line; Cidofovir; Cytidine; Cytomegalovirus; Cytosine; Ganciclovir; Guanosine; Humans; Nucleosides; Organophosphonates; Organophosphorus Compounds; Thymidine	1991
Comparative study of the anti-human cytomegalovirus activities and toxicities of a tetrahydrofuran phosphonate analogue of guanosine and cidofovir. Antimicrobial agents and chemotherapy, 1999, Volume: 43, Issue:3 Topics: Animals; Antiviral Agents; Cell Line; Cell Survival; Cidofovir; Cytomegalovirus; Cytosine; Guanine; Guanosine; Guinea Pigs; Humans; Kidney; Male; Mice; Mice, Inbred BALB C; Organophosphonates; Organophosphorus Compounds; Phosphinic Acids; Rats; Viral Plaque Assay; Virus Replication	1999
New antiretroviral agents. The Hopkins HIV report : a bimonthly newsletter for healthcare providers, 2001, Volume: 13, Issue:2 Topics: Acquired Immunodeficiency Syndrome; Adenine; Anti-HIV Agents; Antiretroviral Therapy, Highly Active; Atazanavir Sulfate; Carbamates; Deoxycytidine; Dioxolanes; Drugs, Investigational; Emtricitabine; Furans; Guanosine; HIV Fusion Inhibitors; Humans; Imidazoles; Oligopeptides; Organophosphates; Organophosphonates; Organophosphorus Compounds; Prodrugs; Protease Inhibitors; Pyridines; Pyrones; Quinazolines; Reverse Transcriptase Inhibitors; Sulfonamides; Sulfur Compounds; Tenofovir	2001
Promiscuous catalysis by the tetrahymena group I ribozyme. Journal of the American Chemical Society, 2005, May-04, Volume: 127, Issue:17 Topics: Animals; Catalysis; Guanosine; Kinetics; Organophosphonates; RNA, Catalytic; Substrate Specificity; Tetrahymena	2005
Bis(tBuSATE) phosphotriester prodrugs of 8-azaguanosine and 6-methylpurine riboside; bis(pom) phosphotriester prodrugs of 2'-deoxy-4'-thioadenosine and its corresponding 9alpha anomer. Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7 Topics: Adenosine; Antineoplastic Agents; Antiviral Agents; Chromatography; Chromatography, Thin Layer; Dideoxynucleotides; Drug Design; Guanosine; Humans; Inhibitory Concentration 50; Models, Chemical; Nucleosides; Organophosphonates; Phosphates; Prodrugs; Stereoisomerism; Thionucleosides; Zidovudine	2005
A cautionary note on the use of the 31P NMR spectroscopy in stereochemical correlation analysis. Nucleosides, nucleotides & nucleic acids, 2005, Volume: 24, Issue:5-7 Topics: Ethanol; Guanosine; Magnetic Resonance Spectroscopy; Models, Chemical; Molecular Conformation; Nucleic Acid Conformation; Oligonucleotides; Organophosphonates; Phosphorus; Phosphorus Isotopes; Protons; Solvents; Spectrophotometry; Stereoisomerism	2005
Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2 Topics: Adenine; Anti-HIV Agents; Diphosphates; Guanosine; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir	2008
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131. Antimicrobial agents and chemotherapy, 2008, Volume: 52, Issue:2 Topics: Adenine; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cell Line; Dogs; Drug Design; Drug Resistance, Viral; Guanosine; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages; Male; Microbial Sensitivity Tests; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors	2008
Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148. Bioorganic & medicinal chemistry letters, 2008, Feb-01, Volume: 18, Issue:3 Topics: Anti-HIV Agents; Fluorine; Guanosine; Humans; Molecular Structure; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Zidovudine	2008
Synthesis and anti-HIV activity of GS-9148 (2'-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor. Bioorganic & medicinal chemistry letters, 2008, Feb-01, Volume: 18, Issue:3 Topics: Anti-HIV Agents; DNA, Mitochondrial; Fluorine; Guanosine; HIV Reverse Transcriptase; Humans; Molecular Structure; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Zidovudine	2008
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation. Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:1 Topics: Adenine; Animals; Cell Line; Cell Survival; CHO Cells; Cidofovir; Cricetinae; Cricetulus; Cytosine; Guanosine; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Kidney; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir	2009
Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148. Bioorganic & medicinal chemistry, 2010, May-15, Volume: 18, Issue:10 Topics: Adenine; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Dogs; Drug Design; Drug Resistance, Viral; Drug Stability; Guanosine; HIV-1; Nucleosides; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured	2010
Improving topical non-melanoma skin cancer treatment: In vitro efficacy of a novel guanosine-analog phosphonate. Skin pharmacology and physiology, 2014, Volume: 27, Issue:4 Topics: Administration, Topical; Animals; Drug Delivery Systems; Guanosine; Humans; Nanoparticles; Organophosphonates; Skin Neoplasms; Tissue Engineering	2014
Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker. Molecules (Basel, Switzerland), 2015, Oct-16, Volume: 20, Issue:10 Topics: Animals; Antineoplastic Agents; Antiviral Agents; Chlorocebus aethiops; DNA Viruses; Dogs; Drug Screening Assays, Antitumor; Guanosine; HeLa Cells; Humans; Inhibitory Concentration 50; Madin Darby Canine Kidney Cells; Organophosphonates; RNA Viruses; Triazoles; Vero Cells	2015