organophosphonates has been researched along with gs-9148 in 6 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (gs-9148) | Trials (gs-9148) | Recent Studies (post-2010) (gs-9148) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 11 | 0 | 3 |
| Protein | Taxonomy | organophosphonates (IC50) | gs-9148 (IC50) |
|---|---|---|---|
| Reverse transcriptase/RNaseH | Human immunodeficiency virus 1 | 1.9 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boojamra, CG; Callebaut, C; Cihlar, T; Gao, Y; Hui, H; Lin, KY; Mackman, RL; Ray, AS; Stray, K; Vela, JE; Zhang, L | 1 |
| Boojamra, CG; Carey, A; Chen, J; Cihlar, T; Douglas, JL; Gao, Y; Grant, D; Hui, H; Laflamme, G; Lin, KY; Mackman, RL; Myrick, F; Pakdaman, R; Parkin, NT; Ray, AS; Vela, JE; White, KL; Zhang, L | 1 |
| Boojamra, CG; Cihlar, T; Douglas, J; Grant, D; Hui, H; Lin, KY; Mackman, RL; Petrakovsky, O; Prasad, V; Ray, AS | 1 |
| Carey, AC; Cihlar, T; Fisher, R; Laflamme, G; Mackman, R; Ray, AS; Vela, JE | 1 |
| Birkus, G; Boojamra, CG; Cihlar, T; Desai, MC; Douglas, JL; Gao, Y; Grant, D; Hui, HC; Laflamme, G; Lin, KY; Mackman, RL; Markevitch, DY; McDermott, M; Mishra, R; Pakdaman, R; Petrakovsky, OV; Ray, AS; Vela, JE; Zhang, L | 1 |
| De Clercq, E | 1 |
1 review(s) available for organophosphonates and gs-9148
| Article | Year |
|---|---|
The clinical potential of the acyclic (and cyclic) nucleoside phosphonates: the magic of the phosphonate bond.
Topics: Adenine; Antineoplastic Agents; Antiviral Agents; Cidofovir; Cytosine; Guanosine; Hepatitis B; HIV Infections; Humans; Organophosphonates; Prodrugs; Structure-Activity Relationship; Tenofovir | 2011 |
5 other study(ies) available for organophosphonates and gs-9148
| Article | Year |
|---|---|
Intracellular metabolism of the nucleotide prodrug GS-9131, a potent anti-human immunodeficiency virus agent.
Topics: Adenine; Anti-HIV Agents; Diphosphates; Guanosine; HIV Infections; HIV-1; Humans; Leukocytes, Mononuclear; Lymphocyte Activation; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tenofovir | 2008 |
Design and profiling of GS-9148, a novel nucleotide analog active against nucleoside-resistant variants of human immunodeficiency virus type 1, and its orally bioavailable phosphonoamidate prodrug, GS-9131.
Topics: Adenine; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Cell Line; Dogs; Drug Design; Drug Resistance, Viral; Guanosine; HIV-1; Humans; Leukocytes, Mononuclear; Macrophages; Male; Microbial Sensitivity Tests; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors | 2008 |
Synthesis and anti-HIV activity of 2'-fluorine modified nucleoside phosphonates: analogs of GS-9148.
Topics: Anti-HIV Agents; Fluorine; Guanosine; Humans; Molecular Structure; Nucleosides; Organophosphonates; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Zidovudine | 2008 |
Novel nucleotide human immunodeficiency virus reverse transcriptase inhibitor GS-9148 with a low nephrotoxic potential: characterization of renal transport and accumulation.
Topics: Adenine; Animals; Cell Line; Cell Survival; CHO Cells; Cidofovir; Cricetinae; Cricetulus; Cytosine; Guanosine; HIV Reverse Transcriptase; Humans; In Vitro Techniques; Kidney; Organic Anion Transport Protein 1; Organic Anion Transporters, Sodium-Independent; Organophosphonates; Reverse Transcriptase Inhibitors; Tenofovir | 2009 |
Discovery of GS-9131: Design, synthesis and optimization of amidate prodrugs of the novel nucleoside phosphonate HIV reverse transcriptase (RT) inhibitor GS-9148.
Topics: Adenine; Animals; Anti-HIV Agents; CD4-Positive T-Lymphocytes; Dogs; Drug Design; Drug Resistance, Viral; Drug Stability; Guanosine; HIV-1; Nucleosides; Organophosphonates; Prodrugs; Reverse Transcriptase Inhibitors; Tumor Cells, Cultured | 2010 |