organophosphonates has been researched along with glutamic acid in 23 studies
| Studies (organophosphonates) | Trials (organophosphonates) | Recent Studies (post-2010) (organophosphonates) | Studies (glutamic acid) | Trials (glutamic acid) | Recent Studies (post-2010) (glutamic acid) |
|---|---|---|---|---|---|
| 9,968 | 880 | 3,596 | 41,757 | 452 | 12,876 |
| Protein | Taxonomy | organophosphonates (IC50) | glutamic acid (IC50) |
|---|---|---|---|
| Chain A, GLUTAMATE RECEPTOR SUBUNIT 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Chain A, Glutamate Receptor Subunit 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Chain B, Glutamate Receptor Subunit 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Metabotropic glutamate receptor 8 | Homo sapiens (human) | 0.0057 | |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | 0.07 | |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor 1 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor 2 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor 3 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | 0.38 | |
| Excitatory amino acid transporter 1 | Homo sapiens (human) | 207 | |
| Glutamate receptor 4 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 0.1533 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (17.39) | 18.2507 |
| 2000's | 12 (52.17) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| De Choszczak, MP; Kafarski, P; Lejczak, B | 1 |
| Kafarski, P; Lejczak, B; Zboińska, E | 1 |
| Hergenrother, PJ; Martin, SF; Spaller, MR | 1 |
| Hamilton, R; Walker, B; Walker, BJ | 1 |
| Iturrioz, X; Llorens-Cortes, C; Maigret, B; Okada, M; Rozenfeld, R | 1 |
| Klinowska, HD; Oja, SS; Saransaari, P | 1 |
| Alexander, SP; De Bank, PA; Kendall, DA | 1 |
| Herreras, O; Larrosa, B; López-Aguado, L; Pastor, J | 1 |
| Han, L; Hiratake, J; Kumagai, H; Sakata, K; Suzuki, H; Tachi, N | 1 |
| Moonen, K; Stevens, CV; Van Meenen, E; Verwée, A | 1 |
| Mellors, JW; Parikh, UM; Sheen, CW; Sluis-Cremer, N; Torres, PS; Zelina, S | 1 |
| Han, L; Hiratake, J; Kamiyama, A; Sakata, K | 1 |
| June Liu, S; Sun, L | 1 |
| Alves, D; Avila, DS; Colle, D; Gubert, P; Nogueira, CW; Palma, A; Rocha, JB; Soares, FA | 1 |
| Gronier, B | 1 |
| Bunik, VI; Kabysheva, MS; Pinelis, VG; Storozhevykh, TP | 1 |
| Bochtler, M; Breer, K; Bzowska, A; Chojnowski, G; Czapinska, H; Girstun, A; Hashimoto, M; Hikishima, S; Narczyk, M; Staroń, K; Wielgus-Kutrowska, B; Yokomatsu, T | 1 |
| Calvez, V; Flandre, P; Fofana, DB; Fourati, S; Katlama, C; Lambert, S; Malet, I; Marcelin, AG; Sayon, S; Simon, A; Soulie, C; Wirden, M | 1 |
| Li, M; Sobolevsky, AI; Yelshanskaya, MV | 1 |
| Chekan, JR; Nair, SK; Peck, SC; Ulrich, EC; van der Donk, WA | 1 |
| Burgett, AW; Hanigan, MH; Heroux, A; Mooers, BH; Smith, CA; Terzyan, SS | 1 |
| Cheong, YK; Li, W; Ren, G; Wang, H; Yang, Z | 1 |
| Bettendorff, L; Bunik, V; Graf, A; Mkrtchyan, G | 1 |
23 other study(ies) available for organophosphonates and glutamic acid
| Article | Year |
|---|---|
Inhibition of aminopeptidases by phosphonic acid and phosphinic acid analogues of aspartic and glutamic acids.
Topics: Aminopeptidases; Animals; Aspartic Acid; Cytosol; Glutamates; Glutamic Acid; Kidney; Kinetics; Microsomes; Organophosphonates; Phosphinic Acids; Swine | 1993 |
Antibacterial activity of phosphono peptides based on 4-amino-4-phosphonobutyric acid.
Topics: Aminobutyrates; Anti-Bacterial Agents; Dipeptides; Glutamates; Glutamic Acid; Microbial Sensitivity Tests; Organophosphonates; Species Specificity | 1993 |
Expression and site-directed mutagenesis of the phosphatidylcholine-preferring phospholipase C of Bacillus cereus: probing the role of the active site Glu146.
Topics: Bacillus cereus; Binding Sites; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Gene Expression; Genetic Vectors; Glutamic Acid; Hydrogen-Ion Concentration; Kinetics; Mutagenesis, Site-Directed; Organophosphonates; Phosphatidylcholines; Plasmids; Recombinant Proteins; Spectrophotometry, Atomic; Substrate Specificity; Temperature; Type C Phospholipases | 1996 |
Synthesis and proteinase inhibitory properties of diphenyl phosphonate analogues of aspartic and glutamic acids.
Topics: Aspartic Acid; Catalysis; Glutamic Acid; Hydrolysis; Kinetics; Organophosphonates; Protease Inhibitors; Serine Endopeptidases | 1998 |
Contribution of molecular modeling and site-directed mutagenesis to the identification of a new residue, glutamate 215, involved in the exopeptidase specificity of aminopeptidase A.
Topics: Amino Acid Sequence; Animals; CHO Cells; Cricetinae; Enzyme Activation; Exopeptidases; Glutamates; Glutamic Acid; Glutamyl Aminopeptidase; Histidine; Mice; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Organophosphonates; Protein Structure, Tertiary; Recombinant Proteins; Sequence Alignment; Substrate Specificity; Transfection | 2003 |
Effect of hepatic encephalopathy on ligand binding to metabotropic glutamate receptors in brain synaptic membranes.
Topics: Aminobutyrates; Animals; Brain Chemistry; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Glutamic Acid; Hepatic Encephalopathy; In Vitro Techniques; Kinetics; Ligands; Male; Organophosphonates; Rats; Receptors, Metabotropic Glutamate; Synaptic Membranes; Thioacetamide | 2003 |
A spectrophotometric assay for fatty acid amide hydrolase suitable for high-throughput screening.
Topics: Amidohydrolases; Ammonia; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoids; Drug Evaluation, Preclinical; Endocannabinoids; Enzyme Inhibitors; Glutamic Acid; Hydrolysis; Kinetics; Liver; Oleic Acids; Organophosphonates; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Rats, Wistar; Spectrophotometry | 2005 |
A role for glutamate and glia in the fast network oscillations preceding spreading depression.
Topics: Animals; Cortical Spreading Depression; Drug Interactions; Evoked Potentials; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Female; Fluoroacetates; Glutamic Acid; Hippocampus; In Vitro Techniques; Nerve Net; Neuroglia; Neurons; Organophosphonates; Periodicity; Piperazines; Potassium; Quinoxalines; Rats; Time Factors | 2006 |
Gamma-(monophenyl)phosphono glutamate analogues as mechanism-based inhibitors of gamma-glutamyl transpeptidase.
Topics: Escherichia coli; gamma-Glutamyltransferase; Glutamic Acid; Humans; Hydrogen-Ion Concentration; Molecular Structure; Organophosphonates | 2006 |
Tandem addition of trialkyl phosphites to alpha,beta-unsaturated imines: a comparison with silylated phosphites.
Topics: Glutamic Acid; Imines; N-Acetylneuraminic Acid; Organophosphonates; Phosphites | 2006 |
Molecular mechanism by which the K70E mutation in human immunodeficiency virus type 1 reverse transcriptase confers resistance to nucleoside reverse transcriptase inhibitors.
Topics: Adenine; Amino Acid Substitution; Anti-HIV Agents; Cytidine Triphosphate; Dideoxynucleosides; Dideoxynucleotides; Drug Resistance, Multiple, Viral; Genotype; Glutamic Acid; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Lysine; Mutagenesis, Site-Directed; Organophosphonates; Phenotype; Reverse Transcriptase Inhibitors; Tenofovir; Thymine Nucleotides; Zidovudine | 2007 |
Design, synthesis, and evaluation of gamma-phosphono diester analogues of glutamate as highly potent inhibitors and active site probes of gamma-glutamyl transpeptidase.
Topics: Binding Sites; Drug Design; Enzyme Inhibitors; Escherichia coli Proteins; gamma-Glutamyltransferase; Glutamic Acid; Humans; Molecular Probes; Organophosphonates; Substrate Specificity | 2007 |
Activation of extrasynaptic NMDA receptors induces a PKC-dependent switch in AMPA receptor subtypes in mouse cerebellar stellate cells.
Topics: Animals; Benzodiazepines; Calcium; Carrier Proteins; Cell Cycle Proteins; Cerebellum; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Mice; Mice, Inbred C57BL; N-Methylaspartate; Neuronal Plasticity; Nuclear Proteins; Organophosphonates; Peptide Fragments; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Synapses; Synaptic Transmission; Time Factors | 2007 |
An organotellurium compound with antioxidant activity against excitotoxic agents without neurotoxic effects in brain of rats.
Topics: Animals; Antioxidants; Brain; Glutamic Acid; Lipid Peroxidation; Mitochondria; Neurotoxins; Nitric Oxide Donors; Nitroprusside; Organophosphonates; Quinolinic Acid; Rats; Rats, Wistar; Synaptosomes; Tellurium; Thiobarbituric Acid Reactive Substances; Vinyl Compounds | 2008 |
Involvement of glutamate neurotransmission and N-methyl-d-aspartate receptor in the activation of midbrain dopamine neurons by 5-HT1A receptor agonists: an electrophysiological study in the rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analysis of Variance; Animals; Dizocilpine Maleate; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Agents; Glutamic Acid; Male; Neurons; Organophosphonates; Piperazines; Prefrontal Cortex; Pyridines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Serotonin; Serotonin Antagonists; Serotonin Receptor Agonists; Synaptic Transmission; Ventral Tegmental Area | 2008 |
Synthetic regulators of the 2-oxoglutarate oxidative decarboxylation alleviate the glutamate excitotoxicity in cerebellar granule neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Glutamic Acid; Ketoglutarate Dehydrogenase Complex; Ketoglutaric Acids; Membrane Potential, Mitochondrial; Neurons; Neuroprotective Agents; Organophosphonates; Oxidation-Reduction; Rats; Rats, Wistar; Time Factors | 2009 |
1.45 A resolution crystal structure of recombinant PNP in complex with a pM multisubstrate analogue inhibitor bearing one feature of the postulated transition state.
Topics: Animals; Binding Sites; Cattle; Crystallography, X-Ray; Enzyme Inhibitors; Glutamic Acid; Glutamine; Glycine; Guanine; Organophosphonates; Phosphates; Protein Multimerization; Purine-Nucleoside Phosphorylase; Recombinant Proteins; Ribose | 2010 |
E138K and M184I mutations in HIV-1 reverse transcriptase coemerge as a result of APOBEC3 editing in the absence of drug exposure.
Topics: Adenine; Anti-HIV Agents; APOBEC Deaminases; Cytidine Deaminase; Cytosine Deaminase; DNA Mutational Analysis; Drug Resistance, Viral; Female; Glutamic Acid; HIV Reverse Transcriptase; HIV-1; Humans; Isoleucine; Lysine; Male; Methionine; Mutation; Nitriles; Organophosphonates; Pyridazines; Pyrimidines; Rilpivirine; Tenofovir; Treatment Failure; Virus Replication | 2012 |
Structure of an agonist-bound ionotropic glutamate receptor.
Topics: Animals; Cross-Linking Reagents; Crystallography, X-Ray; Cysteine; Glutamic Acid; HEK293 Cells; Humans; Ion Channel Gating; Models, Chemical; Organophosphonates; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrimidinones; Quinoxalines; Rats; Receptors, AMPA | 2014 |
A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase.
Topics: Catalysis; Catalytic Domain; Crystallography, X-Ray; Dioxygenases; Glutamic Acid; Histidine; Magnetic Resonance Spectroscopy; Mutation; Organophosphonates; Organophosphorus Compounds; Oxygenases; Protein Conformation | 2015 |
Human γ-Glutamyl Transpeptidase 1: STRUCTURES OF THE FREE ENZYME, INHIBITOR-BOUND TETRAHEDRAL TRANSITION STATES, AND GLUTAMATE-BOUND ENZYME REVEAL NOVEL MOVEMENT WITHIN THE ACTIVE SITE DURING CATALYSIS.
Topics: Aminobutyrates; Apoenzymes; Catalysis; Catalytic Domain; Crystallography, X-Ray; Enzyme Inhibitors; gamma-Glutamyltransferase; Glutamic Acid; Humans; Models, Molecular; Organophosphonates; Protein Conformation; Recombinant Proteins | 2015 |
Neuroprotective Effects of Etidronate and 2,3,3-Trisphosphonate Against Glutamate-Induced Toxicity in PC12 Cells.
Topics: Animals; Apoptosis; Calcium; Cell Nucleus; Cell Survival; Etidronic Acid; Glutamic Acid; Intracellular Space; Neuroprotective Agents; Organophosphonates; PC12 Cells; Rats; Reactive Oxygen Species | 2016 |
Cellular thiamine status is coupled to function of mitochondrial 2-oxoglutarate dehydrogenase.
Topics: Animals; Cerebral Cortex; Cytoplasm; Glutamic Acid; Homeostasis; Ketoglutarate Dehydrogenase Complex; Mice; Mitochondria; Organophosphonates; Succinates; Thiamine; Thiamine Pyrophosphate | 2016 |